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8/20/2019 JURNAL LAIL KULIT
1/15
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Journal Reading“Roles of Adapalene in theTreatment of Pityriasis Versicolor”
Professional Mentor: dr. Bo o !ahyudi" #p.$$ By:%ur &arda 'a(atulail
)*++,-**,
#TA#/ $012T &A% $/1AM2%R#0& $3TA BA%JAR
)*+4
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IntroductionP2T5R2A#2#
V/R#26313RFungal Infection of the skin caused by Malassezia yeast
-
-Discrete orconcrescent-slightlyscaling
macules-
Hypopigmented or
hyperpigmented area
-mainly on theupper trunk
and neck
-clinicalsymptoms
-directmicroscopy
Including:- Zinc
prrithione- Selenium
Sul de- !ntifungalagents
- Retinoicacid cream
Characters Diagnosis "herapies
!dapalenegel:
! tretinoinderi#ati#e
and a
selectionretinoic acidanalogue
Ho$e#er% there are no reports on adapelene for the tratments ofpityriasis #ersicolor
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Sub&ects and Methods
6linical Trial
! prospecti#eDouble blind
'andomi(ed controlled
studyMain aim
"o compare e)cacy ofadopalene $ith * + of
ketocona(ole cream inthe treatment of
pytiriasis #ersicolor
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Sub&ects and Methods
!llpatients
Han people $ith pytiriasis#ersicolor
clinical symptoms, .He/amination
/7clusion 6riteria:Patients :-$ho had recei#ed systemic0topical antimycotic at least 1month prior to the study-$ith serious diseases or other fungal infections-$ith pregnant or nursing mothers-$ith history of allergic to ketocona(ole or adapalene-$ho interupted the treatment
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Sub&ects and Methods
2roup.ne
!dapalene
gel t$icedaily for t$o$eeks
2roup "$o
*+ketocona(olecream t$icedaily for t$o
$eeks
3ligble4atients
During the
studyperiod% theuse ofanotherdrugs $as
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Sub&ects and Methods5Statistics and Analysis)
"o compare se/%age% duration% and
lession a6ected areabet$een t$o group
"o compare theimpro#ement ratefor each treatment
group
Student7s and Mann-8hitney u test
"he / 9 test p #alues ;%;< $ere
considered assigni cant results
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'esults
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'esults
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'esults
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Discussion
"reatment $ithoral ketocona(ole$as e6ecti#e for
4ytiriasis=ersicolor
Many patients$orry about the
side e6ects
4refer topicaltherapy Fre>uent use
4ossibly promotesthe drugs
resistence offungi
Thus" e try notonly clearinfections fungi"
8ut also a9oiddrug resistence
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Discussion
Tretinoin cream $as e6ecti#e for
treatment of pytiriasis#ersicolor adapalene gel is tretinoinderi9itati9e
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Discussion
•
'o can e account for the e cacyof adapalene in the tratment ofpytiriasis 9ersicolor;
!dapalene
1? Strip abnormalkeratynocytes
*? @ormali(e the dysfunction
A? Dicrease the sebumsecretion
"hus
!dapalene gel promotes anen#ironment in hospitable toMalasse(ia yeasts eliminated together iththe a8normal cell layer
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Conclussion
•
In this study $e found that adapalene gel$as not inferior to *+ ketocona(olecream in the treatment of pityriasis#ersicolor?
• !dapalene is a fa#orable option in thetreatment of pityriasis #ersicolor
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'eferences
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"H!@ B.