U . S . DEPARTMENT OF HEA L TH , E DUC ATION, A N D W E L F ARE

4 NIH'ers-Whedon, Hill, Roth and Graff-Honored For Endocrine Research

\ - ..,..,

, l ~ wl-~◄

·.\ ....

Dr. Whedon

Four NIH staff members receiv­ed honors at the Annual Meeting of The Endoc1;ne Society which wa,g held on J une 13 in Atlanta.

The Ayerst A ward for Distin­guished Service in Endocrinology was shared by Dr. G. Donald Whe­don, Director, National Institute of Arthritis, Meta.bolism, and Di­gestive Diseases, and Morris M. Graff and Dr. Robert Towner Hill, both executive sec:retaries, Divi­sion of Research Grants.

Dr. J esse Roth, chief of NIAM­DD's Diabetes Branch, reoeivsed the Ernst Oppenheimer Memorial A ward. That prize is given annu­ally by The Endocrine Society to a young investig,ator for research achievements in endocrinology.

The chairman of the awards committee, Dr. Samuel P. Asper, dean of the Medical School of the American University of Beirut, presented the awards.

He praised the "extraordinary sharing of responsibility and re­markable interaction" between NIH and t hose it serves in t he biomed­ical field.

He cited NI H's role among stu­dents of the life seiences as having "caused profound chll!nges in life style, created enormous ra nges of oppor tunity, and inspired a proud senr.e of profession."

Dr. Asper also lauded NIH ad­(Sec J!JNnoaRTNE AWARDS, Pago 7)

ecor J uly 30, 1974

Vol. XXVl, No. 16 N ATIONAL INSTI T U T ES OF HEALTH

Dr. DeBakey to Head Baylor Research Center Supported by NHLI

The National Heart and Lung l nstitute will award more than $2.5 million for estaiblishing a Na­tional Research and D·cmonstration Center at the Baylor College of Medicine in Houston.

The principal investigator is Dr. Michael E. DeBakey, chairman of t.he department of surgery and p1·esident of rthe medical college.

The progl'alU of <the Blaylo•r Cen­ter will focus on heart and blood vessel diseases, particularly arteri­osclerosis and its complications which, collectively, constitute the Nation's leading health problem.

The center will also work in close cooperation with NHLI which will coordinate center activities with other Institute programs.

Research projects to be under­taken by the center include stu­dies on:

• The morphology of arterio­selernsis; the distribution of arter­iosclerotic deposits in key vessels of the arterial system; the rela­tion shh> between blood-lipid pr o­files; the development of •arterio­sclerotic deposits, and the limd composition of these deposits.

• The physiology of heart mus­cle :and the causes, effects, and therapy of coronary-artery and heart-muscle disease.

• The surgical management of heart and blood-vessel disease, in­cl uding r,emoval or bypass of ,ar­teri,a I obsitructions; the develop­ment and evaluation of mechanical

(Sec BAYLOR. GE~lTER., Page 6)

Dr. Roth

CITE POSSIBLE HAZARD

Molecular Biologists Call for Temporary Ban on Research of DNA Recombinants

Concern over_ a re~ote but possible haza1·d to man has spurred a g-roup of molecular b10log1sts to call for a temporary ban on certain experi­ments that involve the manipulation of deoxyribonucleic acid (DNA) in living cells and viruses.

Sponsored by the National Acad­emy of Sdences, the Committee on Recombinant DNA Molecules suggested thait NIH form a com­mittee to evaluate and advise on the situation.

Also, the group has requested a moratorium on experiments of this type until an international meet­ing is held in early 1975 to discuss future implicaitions, and until guidelines are worked out for par­ticular recombinants.

~IH's Role

Dr. Robe1,t S. Stone, NIH Direc­tor, said in a letter to the NAiS, that NIH has been awa,ce of the situation for some time and that NIH has "been developing guide­lines, soon to be publis'hed, for as­suring containment of such agents" without discouraging research "at this leading edge of science."

Dr. Stone stated that NIH is pre­pared to establish and support the recommended advisory committee and sponsor the suggested meet­ing.

Experiments Noted The new experiments, two spe­

cific types and a possible third, in­volve transplanting ,genetic mate­rial into plasmids of bacteria. Plasmids are extmnuclear DNA which rnplicate like the DNA in the nucleus.

'rhe bacteria not only multiply the foreign genes but also provide an excellent medium for studying the process.

The potential danger is that these altered bacteria, especially FJsolte1·id1ia co1'i - a standard re­search bacter ium that inhabits man's intestines - might eseape and infect the population. I,t is not known what type of genetic ma­terial might be thereafter repli­cated in nature.

The committee recommends that experiments should be avoided that involve injecting into bacteria (I) bacterial genes that are resis­tant to antibiotics and (II) genes of viruses.

Melvin C. Frye hos been named os­sistant director for Protection and Safety Management, OAS. He will serve as principal staff assistant to the OAS Director, responsible for physical security a t NIH-including fire protection . Before t his post, Mr. Frye wos assistant director for Pro• gram Coordination, OAS. He has been ot NIH since 19S8, storting in the Supply Management Branch as supe r­visory purchasing agent . He has also he ld a number of executive ~dmini­strotive posts within the Procure me nt Bronch.

Bldg. I Cafeteria Closes Temporarily for Repairs

The Bldg. 1 cafeteria wa.s closed on July 19 for exten­sive modernization and remod­eling. Work on it will continue for approximately 6 months.

NIH employees on the reser­vation may use the cafeterias in Bldgs. 10, 31, and 35 dur­ing the interim.

The reopening date will be announced.

The third type---placing animal genes in bacteria-"should not be undertaken lightly," the NAS group advises.

Page 2 J uly 30, 1974 THE N IH RECORO

~Record Published biweekly at Bethesda, Md., by the Publications and Reports Branch, Office of Information, for the information of employees of the National Institutes of Health, Department of Health, Education, and Welfare, and circulated by request to interested writers and to investi­gators in the field of biomedical and related research. The content is reprintable without permission. Pictures are available on request. The NIH Record reserves the right to make corrections, changes or dele­tions in submitted copy in conformity with the policies of the paper and the Department of Health, Education, and Welfare.

NIH Record Office . .. ... . .................... Bldg . 31 , Rm. 2B-03. Phone 49-62125

Editor ................ .... .... .. ...... .... .. .. .. .. ...... .... .... .... . ...... . .... .. .. . Fronces W. Davis Associate Editor ...... ...... ........... ....... ..... .. ......... ... .. ............ ........... Foy Leviero Assistont Editor .. .. ..... .. .... ... .. . .. .. . .. .. .. ..... .. .. . .. .. .. .. .. .... ... .. . .. ... . .. .. . Ed Driscoll

Stoff Correspondents ADA, Judy Fleisher; CC, Thalia Roland; DCRT, Joan Chase; DRG, Sue Meadows; DRR, Jerry Gordon; DRS, Cora M. Sult; FIC, George Presson; NCI, Carolann Hooton; NEI, Bonnie Friedman Spellane; NHLI, Bill Sanders; NIAID, Krin Kolsky; NIAMDD, Pat Gorman; NICHD, Kathy Kowalczyk; NIDR, Sue Hannon; NIEHS, EHzabeth Y. James; NIGMS, Wanda Warddell; NINOS, Carolyn Holstein; NLM, Fran Patrick.

Material From NIH Library May Be Returned Via Book Bins Placed in Bldgs. On, Off Campus

The transformation of a U.S. mail box painted in blue, with a white insignia and red, white and blue lettering, into an acceptable receptacle for the return of books borrowed from the NIH Libmry is a switch successfully accom­plished by the Library located in the Clinical Center.

These book boxes are placed in convenient locations on the campus

Mrs. Smith is about to place the sty­rofoom "floor" at the bottom of the bin where the books land ofter they o re inserted through tbe top opening. She coutions employees to please only return books from the N IH Librory, NOT public library books.

and in the Westwood, Landow, and Federal Buildings.

Ruth C. Smith, chief of the Li­brary Branch, Division of Research Services, pointed out that the book boxes were a great convenience for scientists and other NIH employ­ees whose offices were not in the cc.

Red and white signs on the book

bins are clearly marked with the pick-up schedule. At the designa­ted times, library aids unlock the boxes, remove the books and r e­turn them to the NIH Library. For those buildings that are not on the campus, the messengers use the NIH motor pool for transpor­tation.

However, :Mrs. Smith stressed that nnly NIH Library books may be returned via the book bins. And she explained that "We bonow books and journals from othe1· li­braries for the scientists, and this material must be returned in per ­son."

The NIH Libmry chief also said that books from public libraries have been returned in the bins. THAT is a mistake, an cl Mrs. Smith explained why.

"The NIH Library cannot be r e­sponsible for returning books to public libraries. When these books are discovered they will be left outside the book return boxes that they were placed in. Public library fines will certa.i.nly amass; it will not be worth it for the public li-

( .<1r1' 11001' TITX,<t. T'r,n r 7)

USDA Graduate School Catalog Describing Programs Is Available

The new 397-oagc catalog of the Graduate School, U.S. Department of Agriculture- giving inforn1ation about all of the various programs - is now available.

To get a cooy, ooll 447-4419 or write: Graduate School, U.S. De­nart.ment of Agriculture, Room 6847. Soutli Bldg·., 14th and lnde­oendPnre Avenue, S.W., W ,1shing­ton, D.C. 20250.

Yoo-Hoo Mrs. Health, Have We Got Good News for You - You May Be a Winner!

By Ellen Dickstein "Pour yourself a cup of coffee, get very comfortable, and prepare to

hear some wonderful news!"-that's how the letter from a national magazine started out.

Jt was only a computer error. It has happened before, it will happen again- but this time it happened to NIH!

Yes, Mrs. Natl I. Health, "You may have already won the $40,000 Grand Prize in $150,000 'Bes,t of Everything' Sweepstakes. If so, your mailbox is going to be bomb-.,rded-with CASH!"

1f you have ever wondered where your next research grant is coming from, have no fears. That maga­zine's computer understands your problem. It has entered Mrs. Natl f. Health in the "Best of Every­thing!" Sweepstakes.

"Money problems'! Not for you! You'll know how wonderful it is to feel financially secure," the let­ter continued, promising bigger and better things.

This sweepstakes entry arrived recently at the Office of Research Reporting, National Institute of Child Health and Human Develop­ment. It was addressed to "Mrs. Natl l. Health, Bethesda, Mary­land, 20014."

"Can you imagine the but'eiw­Cl'atic snafu it would cause if Mrs. Health won the sweepstakes!" act­ing chief Jane Shure quipped.

Of course, it is possible t hat Mrs. Health may not win the Grand Pdze. But imagine what a nice addition to the Clinical Center the third prize freezer will be.

The se-cond prize would pay for Annual Leave vacations for Mr. and Mrs. Health for 10 years.

All Mrs. Health has to do is r e-

LJ J b i ;;-~* T ,~2"0' t r:26.?lJ * I 0,511,q1 G ~ 7•tJ:.'H 1t ! ?&5000

Look, mo, we ore your children-all 13,135 of us-so that number divid­ed into the prize money makes­figure it out for yourself.

t urn the prize certificates. The computer has reserved a number for each Sweepstakes prize in her name.

T f she returns the certificates promptly, she will be eligible for a $1,000 "Early Bird" Bonus. She is not even obliged to subscribe to the magazine.

The letter reminds Mrs. Health t hat, "If the folks needed help," she would certainly feel good, "giv­ing them a hand." Well, the "folks" do need help. That's what Mrs. Nat l I. Health is here for. So, cross your fingers and hope that :Wrs. Health wins the "Best of Ev­ct·ything."

Dr. Shoron Volle y, o pharmocologist in NLM's Toxicology Information Pro­gram, receives the Regents Award for Scholo rship or Technical Achieveme nt from Dr. John P. McGovern, chairman of NLM's Board of Regents. Dr. Volley, who hos bee n with N LM since 1967, was cited for he r "initiative and creativ­it y in developing unique toxicology informotion products ond scrvici:s." S~~ received her Ph.D. ir, pharmacology from the U. of Michigan.

THE NIH RECORD

DCRT Publishes Booklet For Courses, Seminars; Contains Application

Courses a.nd seminars for the fall semester have been published in a brochure issued by the Train­ing Unit, Division of Computer Research and Technology.

One new seminar, Teleconfe;renc­ing, describes linking computer terminals together for a confer­ence caU. Advantages of telecon­ierencing include permanent tran­s~ribed records, reduced cost, and decreased travel time.

The usual IBM 360/370 general purpose courses will be offered. These include programming lan­guages (I•'ORTRAN, COBOL, PL/ 1, and CPS) as well as instruction 1n the Operating S~stem, WYL­BUR, and microform processing.

Courses Described

Courses in programming lan­guages, operating system and use oi special facilities, as the DEC­system-10, are also available.

The brochures, which contain an application, may be obtained at all .8/1/D personnel offices or by call­ing the Computer Center Branch Teehnical Information Office, Ext. 65431.

Deadline for applications is Aug. 21 although late applications will be accepted until classes are filled.

Harvey Bullock Appointed EEO Counselor for Several NIH Areas

Harvey Bullock, grants manage­ment specialist in the Grants Man­agement Branch, Office of Contract and Grants, ADA, has been ap­pointed EEO counselor for the Of­tice of the Director, the Fogarty Interna,tional Center, and those areas of ADA that are not served by theit- own counselot·.

Mr. Bullock, who has been ac­tive in EEO at NIH for more thm1 10 years, will counsel employees who feel they have been discrim­inated agai nst because of their race, color, religion, sex, na.tional origin, or age. He will also serve as a member of the NIH EEO Ad­visory Council.

Valet and Clothing Center Opens In Bldg. 31; Offers Quick Service

The valet and clothing center has moved to Bldg. 31, Room Bl­E-07 from the Westwood Building. NIH employees on the reservation can now drop their clothes off in the morning and pick them up 2 days later.

The center, open from 8 a.m. to 5 p.m., provides dry cleaning, wa­terproofing, professional altera­tions and repairs, and 3-day shirt service.

Also, such items as women's hos­iery and men's ties and socks can be purchased there. For informa­tion call Ozzie L. Turner, Ext. 63023.

J uly :lO, 197 1

James B. Davis, OAS Director, Retires; Stays Here as R & W General Manager

After 36 years of Federal service-all at NIH--James B. Davis, Office of Administrative Services' Director, retired at the encl of June. Long a member of "Old Timers' " ranks, Mr. Davis recalls, "(1) they sent me to Bethesda, (2) passed the legislation establishing NIH, and (3) built the place- in that order."

Mr. Davis also resigned as president of the Recreation and Welfare Association, Inc., to replace L. D. Weiford, Jr., as R&W general managet·.

He began his Federal career in

In 1962 and ogain in 1973, Mr. Davis was e lected president of the Recreation ond We lfare Association.

1938 at the old Hygienic Labora­tory located at 25th and E Streets, N.W.

Mr. Davis recalls that t he total staff at that time numbered 200 employees, and that what today comprises ADA consisted of 15 people then.

The NIH Budget by that time had r eached a whopping 6 million dollars!

After a World War Mr. Davis in 1945.

2-year tour dm·ing 11 with the U.S. Navy, ret urned to Bethesda

Named OAS Director

When the Clinical Center was built, he assisted with procure­ment and contracting for construc­tion and equipment of the facility.

In 1950, he was appointed chief, Supply Management Branch, and served in that capacity unt il the Office of Administ:riative Services was established in 1969, at which time he was named Director.

The OAS, comprised of 800 em­ploye,es, provides a variety of sup­port and administrative services to NIH scientific and professional personnel.

mobility movement. The conference, held in Hagers­

town, Md., and attended by 100 OAS employees and resource per­sonnel, established goals toward which the organization will direct its future EEO efforts.

Mr. Davis takes pride of OAS EEO accomplishments and of its pioneering role towaa-d upward mo­bility.

Another of Mr. Davis's projects resulted in establishment of the "Davis Plan" drives held annually at NIH during the Christmas sea­son for the benefit of the NIH Pa­tient Emergency Fund.

The plan was conceived by Mr. Davis in 1962 when he deeided to contribute to PEF in lieu of ex­changing Christmas caJ·ds with co­workers.

His friends in Supply Manage­ment jo,ined him in the effort and a total of $261 was donated to the fund.

From this beginning, enthusiasm has spread throughout NIH until annual holiday season donations now total nearly $7,000.

Contributions to the fund assist in providing NTH patients and their families ,vith services that cannot be supported oy approp1fa­ted funds: long-distance telephone calJs home, tobacco, suitcases, a mother's lodging near her child, parties, haircuts, clothing, bus fares, etc.

Mr. Davis also founded the An­nual NIH Reseairch Equipment Exhibit and Symposium on Re.cent Developments in Research Methods and Instrumentation-conducted at

Page 3

I Safety Tips for NIH

AREYoU A COLL(CTOR?

Laboratory collector's items in­clude unlabeled, mislabeled, out­of-date, or decomposed chemicals. Compressed gas cylinders can also be a part of this collecror's cache.

Do some summer housekeeping to dispose of these chemicals.

For information on chemical dis­posal, call the Safety Office, Ext. 65323.

NIH since W51. The meetings provide an oppor­

tunity for an exchange of ideas and information between research scientists in the Washington Met­ropolitan area and t he scientific instrument industry.

The NIH Exhibit and I nstru­ment Symposium has become rec­ognized among th e outstanding scientific meetings on instrumenta­tion in the U.S.

Over the y~ars, Mr. Davis has (See JIM DA. VIS, Pogo 6)

Early in the NIH EEO move­ment, Mr. Davis assumed O A S leadership in NIH upward rn<Ybility efforts. He developed and provided a clerk-typist training program for OAS employees early in 1969 and afforded vocational on-the-job opportunities for a number of em­ployees in dead-end positions.

The OAS EEO conference held in November 1973 climaxed Mr. Davis's efforts in the OAS upward

Dr. Robert S. Stone (c), NIH Director, presents a PHS Commendation Medal and certificate to Dr. Richard B. Stephe nson, Training Officer, OD, for "his effective and wise leadership in enhancing the research troining programs of the National Institutes of Health during a period of transition a nd change .. . " as Mrs. Stephenson looks on.

Page -I THE NIH RECORI

Dr. Boone Tells Summer Employees: 'You Help Us and "It's a two-way street, I tell them. You help us rand we'll help you,

and we'll both get a lot out of it." Dr. Oharles Boone, chief of the Cell Biology Section in t he National Cancer Institute's Viral Biology Branch, supervises several summer employees and finds that this candid approach works very well.

Dr. Boone e:irplained ·that summer workers "offer the supervisor a chance to try the simple, high curiosity projects, that we can't afford to spare personnel for in our own productive activities."

This June, summer employment at NIH reached its peak. More than 800 high school, college, and graduate ~dents were hired for scientific, administrative, clerical, and maintenance jobs on the campus and in Ins titute -field locations.

Of ,the eight summer programs, the Stay-in-School Program h:as the largest number of participants---over 450 employees. This year-round program enables the student to work full-time during the summer and continue working part-time during the school year.

Herbert Smallwood examines highly inbred strain of guinea pigs used in NIAID immunity studies.

Medical stude nt Andrea Leonard ex­amines a tissue culture of cance r cells in a n NCI laboratory.

One fourth of the summer employees are summer aids, working in clerical, administrative, and apprenticeship research jobs. The Summer Aid Program enables economically disadvantaged youths, between the ages of 16 and 21, to develop skills through on,the-job training.

The employee may also participate in 36 hou1·s of classroom training.

College stude nt Steve Hsiao works in compute r program­ming in the DCRT physical sciences lab.

Warking in HINDS' Infect ious Diseases Branch, premed stude nt Lakita Conley feeds a Cynomolgus monkey used in research for transmission of viruses.

Working with radioactive mate rials, Nathan Lewis assists in enzyme studies for NCI. He is a chem istry g raduate of Oakwood College in Alabama.

Robert Randolph assists in darkroom techniques for the DRS Medical Arts and Photography Branch.

Jonna Moore assists in journal control and distribution of work ta foreign as• sociates far NLM.

Photos by

Text by .Jue

Working in microph, T im Lavelle transfer microfilm,

tD July 30, 1974 Page 5

We'll Help You and We'll Both Get a Lot Out of It' This year, the Summer Aid Program included six students with audi­

tory or visual handicap;, who were placed in jobs where their talents could be utilized. The students were so successful in theh- work, that plans are now underway to continue with this part of the program next year.

The Federal Junior Fellowship Program gives college and college bound students training in fields related to their school studies. The goal of the program is to attract talented young people into Government careers and provide financial assistance to continue their education.

In August, a Youth Participation Day for students to meet wiLh B/ 1/ D administrators will be held.

Seminars, at which students will hear health topics discussed by the professional staff, are also planned for t hat month. The stud,ents will choose the topics and participate in the d iscussions.

For the first time, s ummer employees will nominate a candidate for the title of top supervisor of the summer, stating their reasons for the selection. An award will be presented to the winning supervisor during t he 5th Annual Summer Employees Awards Assembly.

Other summer proguams include: Summer Employment Examination Prngr.am, the Graduate Program, COSTEP, the AU Resea1·ch Participa­tion Program, and the Fe<leral Summer Intern Program.

Miche lle Minar, an OES signpainter, gives summer employee Tony Ben­nings o lesson in lette ring.

English Willis, a g raduate of Ame r­ican U., tests liver ce lls in culture contamination in on NCI lab.

1 Tom Joy

Jdy Fleisher

,hotagraphy at NLM, ers scientific texts to

Pre med student Steve Adler performs viral titrations as part of s low virus studies in NINOS.

Morris Cunningham wires an electronic assembly in the neura I control labora­tory of NINOS.

At HHLI, Howard Sandler uses distilla­t ion apparatus to recover radioact ive products from plasma.

Chorles McMillan assists Dr. Richard Killens, DRS, in examining a heart and lung bypass "patient."

Dr. Meero Paranjpe, NCI stoff biologist, explains the use of time lopse photography in studying malignant cells to college student, Sharan Faltz.

Page 6

Dr. Samuel Greenhouse Leaves the Government After 34 Years' Service

AL a .fan,well testimonial party in nonor of Dr. Sm11uel W. G1·een-110use, a guest said, "I just never met anybody who had anything to do with Sam wno didn't bhink that, in add1t1on to being a fine statis­tician and a fine scientist, he was JUSt a gre,at human b<!ing."

ur. Greenhouse recently retired as assoiiate director for Epidemi­o.ogy and Biometry and acting as­~J,iate ctirettor for Program P lan­.ii.,g and Evaluation, National I n­s titute or Cnild Health and Human uavc.opment, afte,r 34 years of li-overnment service.

W, 11 Join GWU He will join the staff of George

Yiasl\ington VniV'ersity as a pro­tess; r o; statistics.

Ur. Greenhouse was given a bound collection of his puiblications, a s~rapbook of letters from col­,eagues and friends from the world over, and a scientific pocket calcu­lator.

A gold ring with opals, sap­phui.s, and diamonds was presented LO Mrs. Greenhouse to commemo-1·a.te tne occasion.

Vt. Greenhouse gr,aduated from City College of New York in 1938 and received his B.S. in 1954 and llis Pn.D. in 1959 in statistics from u\/ U through a combination of studying, teaching, and wo,rking.

lie llrst came to the Government in 19-10 with the Bureau of the Cer.sus, spent 1942 through 1945 w,tn the U.S. Army, and then wor:~ed for the next 3 years with the U .N. Rehabilitation and Re-lief Asso~iation.

Dr. Greenhous,e began his NIH career in 1948 with NCI. Leaving that Institute in 1954, he accepted a position as chie f of the Theo­retical Statistics and Mathematics Section, NIMH.

In 1966 he came to NICHD to organize and act as first chief of

J uly 30, l !J7-I

Clinical Ce nte r pa t ients and friends meet a lion-a friendly one-in the 14th floor playroom . The visitor, a representative of the W ild life Preserve, a pa rk to open soan in Lar90, Md., prowled nursing units ond outpot ient clinics, The vis:t was orranged by the CC Patient Activity Section.

the Epid-emiology and Biometry Branch.

Dr. Greenhouse became EBB as­sociate director in 1971 and con­current,y assumed the post of act­ing associate director for Program P'.anning and Evaluation.

Early in his NIH career, he helped design methods of evalu­ating diagnostic tests for various typ€s of diseases.

Later, Dr. Greenhouse worked on n, w statistical methods for profile analysis to solve problems of test­ing, chiefly in the mental health area.

Also intell'-ested in multivariate ana!ysis, he has published numer­ous articles on discrimination, clustering, and more l'ccently, case control study analysis.

'fhe recipient of many honors and awards, Dr. Greenhouse was recently selected by Johns Hopkins University as a Johns Hopkins Centennial Scholar.

BAYLOR CENTER ( Oonrinued frnm l'OflC 1)

devices to provide pumping assist­anc,e to heavily damaged or failing hearts.

• Immunological f,ac:tors th a t may opei,ate in the development of arteriosclerosis or else may be activated by the disease process.

& Blood resources and the prob­lem of hepatitis, particularly . as t hey 1·elate to open-heart surgery.

Control and Demonstration Proj­ects include:

<t Application i n community clinics and hospitals of preventive, treatment, and rehabilitat ive pro­cedures as practiced in the Baylor Cardiovaswlar Genter.

• Evaluation in special ambu­lances of telemetering equipment permitting physicians in participat­ing hospitals to monitor the clini­cal status of heart-attack cases or victims of other cardiovascular emergencies and to supzrvise their treatment while the patient is en route to the hospital.

Pr09ra m Explained

19 Alteratio,n of risk factors strongly associated with increased susceptibility to coronary heart dis-ase and its complications, such as a ~ute heart attacks. In particu­lar, the p,·ogram will concentrate on elimination or reduction of cig­are tte smoking and the modifica­tion of habitual dietary patterns ( diets high in calories, total fat, and cholesterol) that tend to raise blood lipid levels.

At the retire ment dinne r, Dr. Greenhouse stands with his wife Selma (r), and his sec retory A9nes Sweeney.

• A program to institute stand­ardized procedures to measure blood levels of cholesterol and tri­glycerides (the two key blood­lipid fractions) among community laboratories.

THE NIH RECORD

NIH Visiting Scientists Program Participants

7/ 1-Dr. Evan Anthony J ones, United }{jngdom, Digestive Diseas­es Branch. Sponsor: Dr. Paul D. Berk, NIAMDD, Bg. 10, Rm. 4D52.

7/ 1-Dr. Takeshi Ka.to, Japan, Laboratory of Biomedical Sciences. Sponsor: Dr. Gordon Guroff, NIC­l-1D, Bg. 6, Rm. 310.

7/ 1- Dr. Karl M. Knigge, U.S.A., Labomtory of Biomedical Sciences. Sponsor: Dr. David C. Klein, NICHD, Bg. 6, Rm. 140.

7/ 1-Dr. Takuma Kondou, Jap­an, Reproduction Research Branch . :::iponsor: Dr. Kevin S. Catt, NlC-1:1v, Bg. 10, Rm. 12N218.

7/ 1-Dr. Ramon Latorre, Chile, Laborotory of Biophysics. l::;,ponsor: Dr. William Adelman, NINUS, Bg. 36, Rm. 2A29.

7/ 1- Dr. George J. Mathews, In­dia, Surgical Neurology Branch. Sponsor: Dr. J. M. Van l5u:ren, :N1NUS, Bg. 10, Rm. 4N236.

7/ 1- Dr. Edwige Panek, France, Laboratory of Technical Develop­ment. Sponsor: Dr. Robert L. Ber­ger, NHLI, Bg. 10, Rm. 5D04.

7/ 1-Dr. Ernesto J. Podei;te, Ar­gentina, Reproduction kesearch .&-anch. Sponsor: Dr. Maria Catt, NICHD, Bg. 10, Rm. 12N216.

7/ 1- Dr. Rodwan K. Rajjoub, Sy1·ia, Surgical Neurology Brnnch. Sponsor: l>r. J. M. van Buren, NINDS, Bg. 10, Rm. 4N236.

7 / 1-Dr. Norio Sakuragawa, Japan, Clinical lnvestigat1on.s and Therapeutics ' Sections. S,ponsor: Dr. Anatole De~aban, NINUS, Bg. 10, Rm. 4N248.

7/1-Dr. Caroline van Haaften, Netherlands, Lung Cance1· Branch, DCCP. Sponsor: Dr. Cw·tis C. Har­ris, NCI, Bg. 37, Rm. 3-C03.

JIM DAVIS ( (;011l i n11 e,I from Page 3)

served on various committees to resolve problems dealing with pur­chase of land, training programs, sa.tety management, security and protection, cont1·act policy, contract disputes, credit union activities, and facilities planning.

Recruited by the Department of Commerce in 1967, Mr. Davis serv­ed as a consultant in organizing the ACHEMA Exposition held in Frankfurt, Germany, for world­wide exchange of data concerning scientific equipment.

Again in 1970 he was detailed to Commerce to organiz-e the Interna­tional Colloquium dealing with An­alytical Instrumentation for Indus­try and Research at the U .S. Trade Center in Paris.

This year- from July 10 through August 11-Mr. Davis is serving as U.S. Technical Representat ive at Analytical and La~atory ln­strument Catalog Exhibits in the Philippines, Singapore, an d Ma­laysia.

THE NIH RECORD

WARNING-Numerous speeding comploints hove prompt­ed the inougurotion of compus ,odor speed surveillonce by the NIH Special Police, Two teams of officers will set up at selected locotions at different times of the doy or n ight. A training team has completed surveys of various trouble spots where moving violations are most prevalent. Motorists recently stopped- many of them NIH'ers- have been issued warning tickets with the copies placed a n file -second offenders will be given citations. Le ft: Lt. Floyd

Rush uses a battery-operated " Speedgun"-portable radar- which registers a car's speed when pointed at the moving vehicle. Center : Placed on the rear door, the sending and receiving unit (arrow) of the stationary radar is monitored inside the patrol car by Pfc. Harry Le vine Ir), who obtains o vehicle's speed on a digital readout. The reservation's poste d maximum speed limit is 20 miles per hour. New signs reading "Rodar Enforced" hove been added to all speed limit signs throughout the campus .

Applications Are Being Accepted to Four NIH Special Career Research Programs

Applications for four special research career programs will be accept <"d by NIH from U.S. ci'tizens, non-citizen nationals, or t hose lawfully ad­mitted to this country for permanent residence.

Candidates must be nominated public or private organization lo­cated in the U.S., its possessions or territories, and must have dem­onstrated potential for developing qualifications necessary to pursue careers in research and academic medicine.

Awards will be made to th c sponsoring institution or school on behalf of the candidate in one of the following health professional categories.

New Program to Provide Career Opportunities Here

A new inservice develop­ment program for employees in the Office of the Director, the Fogarty International Cen­ter, and the office of the As­sociate Director for Adminis­tration was recently announced by Leon Schwartz, Asoociate Director for Administration.

Its purpose is to increase the potential advancement for employees, and also provide them with the opportunity for better careers.

Developed by the OD-FIC­ADA EEO Advisory Commit­tee, the program is built on the current New Careers Pro­gram. It involves both on-the­job and outside tr aining for selected participants.

Candidates for the program must be full-time permanent employees who are at or be­low the GS-7 level or waj!'e grade equivalent.

by an appropriate non-Federal

• The National Heart and Lung Institute's 1'11111,r,1111r11 A 1·r11/1'111ir· • I 1Nu·f/., are aimed at improving puJmonary curricula and fostering research and academic careers in the r espiratory fields.

These awards are limited to one for each eligible school of medi­cine or osteopathy for a period of up to 5 years with the possibility of renewal for an additional 3 years.

Contact Dr. Jay Moskowit z, Di­vision of Lung Diseases, NHL!,

BOOK BINS ( Con ti,uH•,I from, Paac 2)

brary user." Mrs. Smith suggested that em­

ployees who do not know the loca­tion of the book bins may contact their administrative officers for the information.

Under Mrs. Smith's aegis, the NIH Library will soon establish another innovation-a card cata­log, duplicating the one that is on the main floor, will be installed on the lower level.

Mr,s. Smith, who has headed the library for a little over a year­she came to NIH from the Scien­tific Documentation Division, Na­val Ship Systems Command-also said that future libvary projects wiH include automation programs, and the development of a non­print media collection using micro­fiche and both video and audio tape recording.

Bethesda, Md. 20014. 9 .Hlei-r1ir· Di.•ca8<J8 Aratlemin

. l1ron/.!, Sl}()IIJSOl'C'cl I,~• fhf' Xationnl Institute of Allergy and Infectious Diseases, provide an opportunity for young s:ientists to develop qual ifications for established aca­d'>mic positions in allergic diseases.

Candidates should be under -10; ha v c an M.D., D.O., D.M.D., D.V.M., or equivalent degree, and have 5 to 10 year s of postdoctoral experience in areas relevant to al­lergic diseases.

Contoct Dr. Froehlich

Contact Dr. Luz A. Froehlich, assistant fo r Clinical Program~­Extramural Programs, NJAID.

• The National Institute of Arthritis, :v1etabolism, and Dil!'es­tive Diseases is accepting applica­t ion~ for Clinical lll1'P8tigatnr A l<'al'fl.• in rlii;:esth·e rlif'e:u,e~, nut1·i ­t ion, and diabetes.

The 3-year awards are desigMd to foster independent research cap­ability in young medical scientists -with 3 to 7 years of nostdoctor­al PXnerience-holding M.D., D.O., D.M.D., D.V.M., or equivalent de­grees.

Nl~DS Award Noted

Contact Dr. William Batchelor, Clinical Investigator Awa,·ds-Ex­tramural Programs, NIAMDD.

8 1'e,whc1·-T111:c8li.f/a/m· . I 1rnrr1., in neurological and communicative nisorders will be continued by the National Institute of Neurological Diseases and Stroke.

The 5-year awards provide sup­nort to candidates purs,uing a re­search and teaching nroirram which has bee n planned with the sponsor. Up to 10 new awards will be made annually.

Contact Dr. Ray Summers, act­ing chief, Special P r o gr a m s Branch, Extramural Programs,

Page 7

ENDOCRINE AWARDS (C1011th111e<i Jt·om, Page J)

ministrators. He said they "under­stand s:ience and scientists and provide the indispensable human concern, honest candor, integrity and trust."

Dr. Whedon, Mr. Graff, and Dr. Hi l were cited "for their high qualities of character and achieve­ment." Dr. Roth was honored "for his intellectual virtuosity, for his investigative talents and his scien­tific accompl ishments."

Two days later, in the same city, Dr. Roth r eceived the 1974 Lilly Award at the Annual Yleeting of the American Diabetes Association.

At that conference, he was cited for his "a~complishments in de­monstrating the secretion of growth hormone, the &ecretion of proinsulin and the assessment of its blood levels, and more recently, in the important ar ea of hormone r eceptors in various t issues such as liver and lymphocytes."

Or. Hill

Mr. Groff

NINDS. More deta iled information and

applications may be obtained hy contacting the appropriate partici­pating Institute.

The deadline for receipt of ap­plications is Oct. 1, 1974. Notifica­tion of final action will be made in March 1975.

More people die from aJJergy to insect stings than from snake b~tes. - .J.J :lf.l P in.,· 6 i~~11e l.

Page 8 July 30, 1974 THE NIB RECORD

Heart Scanning Technique for Children, Voice Abnormalities of Rhesus Described

A team of investigators from the Division of Research Services and the National Heart and Lung lnstitute developed a new tech­nique useful in visualizing cardiac abnormalities of infants and chil­dren with congenital heart dis­ease.

Called 2-dimensional echo-cardi­ography - the scanning technique otters a new use of biomedical ul­trasound, a sonar-like diagnostic system in which sound waves transmitted to a human body send back characteristic echo-waves from various tissues and blood vessels.

The 2-dimensional technique was described in the current issue of the s : ientific journal l'irculation by James M. Griffith, a DRS electrical engineer, and Dr. Walter L. Henry, an NHL! cardiologist.

Un!ike one-dimensional u ltra­sound systems presently in use, the new system permits visualization of a large part of the heart as it bzats, and produces 30 separate pi: t ures of the heart each sec(}nd.

Ea~h individual picture consis:s of 100 lines-of-scan, providing gTeater detail than, other rep(}rtcd 2-dimensional systems.

Dr. Henry explained that cardiac prob!ems o:f small children ar e not easily diagnosed because of the s.nall s ize of their hearts.

Cardia~ catheterization, the sur­gical insertion of an examining instrument into the heart, is some­times a risky procedure in young­sters with unknown cardiac abnor­malities which may range from narrowe'd heart valves and improp­er:y connected blood ves,sels to mis­location of the heart itself.

The scientists report that a hun­dred patients with heart disease have been screened at NIH ,vitbout risk or discomfort using the new technique. Of these, 23 patients had congenital heart disease.

Twenty of the 23 cases were

The 2-dimensional ultrasound scon­ner, hand-held to a card iac patient's chest, is approximately 4 " long and 3" high. View is of the patient's left chest-the scanner is oriented to scan along the long axis of the heart's left ventricle. The sound-sen­sitive element rocks rapidly on the chest but is not conside red uncom­forto ble by patients.

The voiceprints of rhesus mon­keys separated at birth from their mothers and isolated from other monkeys demonstrate some of the same abnormalities noted in sounds made by human patients with neu­ro logic and psychotic disorders.

Drs. John D. Newman and Da­vid Symmes, National Institute of Child Health and Human Develop­ment, reported this finding in an article titled Vocal Pathology in Socially Deprived Monkeys, pub­lished in the journal Dcvdopmon­ral l'-•J/Cii<,biolf/(JY,

The scientists studied two male and two female rhesus macaque monkeys deprived of physical con­tact with other monkeys from birth, and who had a minimum amount of handling by human at­tendants.

The animals wer-e raised in sep-

During on afte rnoon tour of the cam­pus, science writers visit a NICHD lab. There, Dr. Symmes holds up a voiceprint of rhesus monkeys de­prived of the companionship of other monkeys at birth. Sound abnormal­ities include abrupt pitch changes and lack of inflection .

• • corl.'ectly identified with the 2-di­mensional echo-cardiographs, Dr. Henry noted.

The NIH system is motor-driven and relatively inexpensive. Mr. Griffith and Dr. Henry estimate that as many as 3,000 U.S. medi­cal centers al'l'eady are equipped with ultrasound units, now used chiefly for brain tumor diagnosis, fetal monitoring a n d one-dimen­sional e~ho-cardio,graphy.

Many such units are adaptable to the NIH type of 2-dimensional echo-cardiography, they said.

The NIH researchers acknowl­edged signific,mt contributions to 2-dimensional echo - cardiography made ,by earlier investigators.

They cited in particu1ar research teams by Erasmus University in Rotterdam, Holland, the University of Rochester , Indiana University, Duke U., Stanford U., and the Ui1i­versity of California, San Die.go.

Mr. Griffith and Dr. Henry were among a group of NIH stientists using one-dimensional echo-cardi­ography in collaboration with NA­SA physicians in February 1974 t-0 monitor the hearts of Skylab Ill astronauts following their pro­longed period of weight lessness.

arate incu1bators in the same room until about 1 month of age, then wel'e trans.fern-ed to individual cages where they could see and hear, but not touch, many other rhesus macaques of all ages.

Video tape recordings of these, a n d three mother-reared rhesus macaque monkeys which served as controls, were made when the ani­mals were 9, 12, 16, and 24 months of age. The v(}Calivations were an­alyzed with a sound spectrogr aph.

Structural abnormalities were found in the clear (non-noisy) calls, or "coos," of the socially­deprived monkeys (as distinguish­ed from the louder squeaks or sc·reeches).

These abnormalities included abrupt pitch chlld'lges, harmonic emphasis shifts, breaks in the con­tinuity of ·sound, lack of inflection, and a "hollowness" of sound.

Although all of t he deprived monkeys produced sounds with more than one o:f these structural abnormalities, each monkey had a d istinctive set of abnormalities which characteri~d m:ost of its clear calls at every age in the test period.

Voiceprints obtained in stuclies of human adults with mental ill­ness by Dr. Peter Ostwald in 1961, and of brain-damaged infants by Dr. Ole Wasz-Hockert and col­leagues in 1968, demonstrated com­parable patterns of abnormality.

One type of exception to the typical abnormal vocalization was observed in several instances when deprived monkeys were held or when an observer was near-by.

On these rare oceasions, the de­prived monkeys gave "coos" indis­tinguishable from those of the con­trol group. "Coos" from the con­trol monkeys, including those heard during brief separations of these animals from their mothers, had a smooth, g r adually inflected har­monic structure and we-re unbroken in sound.

The present report is believed to be the first analysis of voice path­ology o:f primates socially isolated from birth.

Grant

. d by investigator f Project conceive /

INIH supp,rts or assists

Ors. Cooper and Stone Address News Writers At I-day NIH Seminar

On July 11, the concluding day of the second annual Fedez,al Focus on Health Conference, journalists specializing in 1·e,porting science and health news abtended a semi­nar at NIH.

Dr. Theodore Cooper, HEW Dep­uty Assistant Secretary for Health, opened th e morning session in Wilson Hall. He discussed the role of the Federal Government in bio­medical resea,reh. Dr. Cooper was formerly Director o:f the Nrutional Heart and Lung Institu,te.

He was followed by NIH Direc­tor Dr. Ro·bert S. Stone who gave an explanation - illustrated by slides--on the structure of NIH, and its budget and peer review system.

Later, three Institute Directors described the research progiiams of their respective institutes. They were: Dr. David Rall, National In­stitute of Environmental Health S::-iences; Dr. Ro.bert Ringler, Act­ing Dir,ector, NHL!, and Dr. Frank J. Raus~her, Jr., National Cancer Institute.

Tours Conducted

The morning session concluded with talks by Dr. Elizabeth Neu­feld, National Institute o:f Arth­ritis, Metabolism, and Di,gestive Diseases, and Dr. William H. Bo­wen, National Institute of Dental Research. Dr. Neufeld's topic was Inborn Errors of Metabolism; Dr. Bowen discussed Prospects of a Caries Vaccine.

During the afternon session, groups of reporters toured th e Clinical Center and the National Library of Medicine.

They also visited laboratories to view some of t he research that is being conducted on the campus. Two of the studies are described in adjoining columns.

. t conceived by NI t Pro1ec

· eor fNIH procures serv1c

Dr. Stone explains tlte 5tructure of NIH ond its budget and peer review syste m. Other scientists at the seminar described reseorch ot their Institutes.

* U . S . GOVERNMENT PRINTI NG OFFICE: 1973- 544,802/ 23