Journal of Clinical PathologyJwuary 1986 Vol 39 No 1

ContentsReview articleEosinophilic infiltrates of the gastrointestinal tract AJ BLACKSHAW, DA LEVISON page 1Immunophenotype analysis of malignant histiocytosis of the intestine DM SALTER, AS KRAJEWSKI,AE DEWAR page 8Malignant histiocytosis complicating rheumatoid arthritis: report of four cases AS JACK, BF BOYCE,FD LEE page 16Cervical glandular atypia associated with squamous intraepithelial neoplasia: a premalignant lesion?LJR BROWNsi WELLS page 22Does ovarian sex cord tumour with annular tubules produce progesterone? J DOLAN, AH AL-TIMIMI,SM RICHARDS, JB JEFFS, GC MASON, DB SMITH, PS HASLETON page 29New concept in diagnostic endometrial cytology: diagnostic criteria based on composition and architectureof large tissue fragments in smears ELSA SKAARLAND page 36Cryostat section assay of oestrogen and progesterone receptors in meningiomas: a clinicopathologicalstudy JW IRONSIDE, RDE BATTERSBY, VICTORIA JM DANGERFIELD, MA PARSONS, WR TIMPERLEY,JCE UNDERWOOD page 44Study of childhood renal tumours using antisera to fibronectin, laminin, and epithelial membraneantigen S KUMAR, T CARR, HB MARSDEN, MC CALABUIG-CRESPO page 51

Alpha-l-antitrypsin and the liver: a routine immunohistological screen JM THEAKER, KA FLEMING page 58Hepatic vein lesions in alcoholic liver disease: retrospective biopsy and necropsy study AD BURT,RNM MaCSWEEN page 63Clinical pathology of acute necrotising pancreatitis I NORDBACK, K LAUSLAHTI page 68Is tissue polypeptide antigen more accurate than serum CEA for diagnosing pancreatic cancer?A PANUCCI, C FABRIS, G DEL FAVERO, D BASSO, F DI MARIO, L MARCHIORO, A PICCOLI, M LISE, A BURLINA,R NACCARATO page 75Study of postoperative chest infections with particular emphasis on those caused by Haemophilusinfluenzae GM TEBBUTT page 78Chronic respiratory disease in premature infants caused by Chlamydia trachomatis K NUMAZAKI, S CHIBA,K KOGAWA, M UMETSU, H MOTOYA, T NAKAO page 84Evaluation of lysis filtration as an adjunct to conventional blood culture RACHAEL CHAN,ROSEMARY MUNRO, P TOMLINSON page 89Survival of Gram positive anaerobic cocci on swabs and their isolation from the mouth andvagina GILLIAN LF SMITH, CG CUMMING, PW ROSS page 93Correlations between nuclear morphology and bundles of cytoplasmic fibrils in 50 cases of actute myeloidleukaemia EC PEARSON page 99Racial differences in red cell indices D ISAACS, DG ALTMAN, HV VALMAN page 105Guidelines on authorship page I10

Technical methodsStaining of mycobacterium leprae in epoxy resin sections KE BRASSIL page 111Detection of Campylobacter pyloridis in gastric mucosa by phase contrast microscopy KEITEE J PINKARD,B HARRISON, JA CAPSTICK, G MEDLEY, JR LAMBERT page 112

Letters to the Editor page 114

Book reviews page 120

Notices page 120NATIONAL LIBRARY OF MEDICINE

ASTM CODEN: JCPAAK 39(1) 1-120 (1986) ISSN 0021-9746

NLM 00584855 0

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ContentsNo I JANUARY 1986 Page

Review articleEosinophilic infiltrates of the gastrointestinal tract AJ BLACKSHAW, DA LEVISON............................................ IImmunophenotype analysis of malignant histiocytosis of the intestine DM SALTER, AS KRAJEWSKI, AEDEWAR. 8

Malignant histiocytosis complicating rheumatoid arthritis: report of four cases AS JACK, BF BOYCE, FD LEE.16Cervical glandular atypia associated with squamous intraepithelial neoplasia: a premalignant lesion? LJR BROWN, M WELLS.22Does ovarian sex cord tumour with annular tubules produce progesterone? S DOLAN, AH AL-TIMIMI, SM RICHARDS, JB JEFFS, GC MASON,

DB SMITH, PS HASLETON.29New concept in diagnostic endometrial cytology: diagnostic criteria based on composition and architecture of large tissue fragments

in smears ELSA SKAARLAND.36Cryostat section assay of oestrogen and progesterone receptors in meningiomas: a clinicopathological study JW IRONSIDE, RDE

BATTERSBY, VICTORIA SM DANGERFIELD, MA PARSONS, WR TIMPERLEY, JCE UNDERWOOD.44Study of childhood renal tumours using antisera to fibronectin, laminin, and epithelial membrane antigen S KUMAR, T CARR, HB

MARSDEN, MC CALABUIG-CRESPO.51Alpha-l-antitrypsin and the liver: a routine immunohistological screen JM THEAKER, KA FLEMING.58Hepatic vein lesions in alcoholic liver disease: retrospective biopsy and necropsy study AD BURT, RNM MaCSWEEN.63Clinical pathology of acute necrotising pancreatitis I NORDBACK, K LAUSLAHTI.68Is tissue polypeptide antigen more accurate than serum CEA for diagnosing pancreatic cancer? A PANUCCI, C FABRIS, G DEL FAVERO,D BASSO, F DI MARIO, L MARCHIORO, A PICCOLI, M LISE, A BURLINA, R NACCARATO.75Study of postoperative chest infections with particular emphasis on those caused by Haemophilus influenzae GM TEBBUTT 78Chronic respiratory disease in premature infants caused by Chlamydia trachomatis K NUMAZAKI, S CHIBA, K KOGAWA, M UMETSU, H

MOTOYA, T NAKAO.84Evaluation of lysis filtration as an adjunct to conventional blood culture RACHAEL CHAN, ROSEMARY MUNRO, P TOMLINSON 89Survival of Gram positive anaerobic cocci on swabs and their isolation from the mouth and vagina GILLIAN LF SMITH, CG CUMMING,

PW ROSS.93Correlations between nuclear morphology and bundles of cytoplasmic fibrils in 50 cases of acute myeloid leukaemia EC PEARSON 99Racial differences in red cell indices D ISAACS, DG ALTMAN, HV VALMAN.105Guidelines onauthorship. 110Technical methodsStaining of mycobacterium leprae in epoxy resin sections KE BRASSIL.11Detection of Campylobacter pyloridis in gastric mucosa by phase contrast microscopy KEITEE S PINKARD, B HARRISON, JA CAPSTICK,G MEDLEY, JRLAMBERT. 112Letters to the Editor.114Book reviews.120Notices.120

No 2 FEBRUARY 1986

Aplastic and hypoplastic episodes in sickle cell disease and thalassaemia intermedia ALISON I BROWNELL, DA MCSWIGGAN, WD CUBITr,M1ANDERSON.121Idiopathic haemochromatosis and HLA antigens in Italy: Is A3 Bw35 HLA haplotype a marker for idiopathic haemochromatosis genein north east regions? A PIPERNO, S FARGION, N PANAIOTOPOULOS, E DEL NINNO, MT TADDEI, G FIORELLI.125Platelet volume analysis in the differential diagnosis of thrombocytosis J VAN DER LELIE, AEG KR VON DEM BORNE.129Marrow involvement in T cell lymphoma initially presenting as abnormal myelopoiesis MJ AUGER, JRG NASH, MS MACKIE.134Laminin and fibronectin in adenoid cystic carcinoma AS d'ARDENNE, P KIRKPATRICK, CA WELLS, JD DAVIES.138Cyclosporin and renal graft histology AS d'ARDENNE, MS DUNNILL, JF THOMPSON, D MCWHINNIE, RFM WOOD, PS MORRIS.145Morphological differentiation between rejection and cyclosporin nephrotoxicity in renal allografts GH NEILD, DH TAUBE, RB HARTLEY,L BIGNARDI, JS CAMERON, DG WILLIAMS, CS OGG, C RUDGE.152Lupus nephritis: clinicopathological study of 162 cases in Thailand P PARICHATIKANOND, ND FRANCIS, P MALASIT, T LAOHAPAND, S

NIMMANNIT, L SINGCHOOVONG, S NILWARANGKUR, P CHRIRAWONG, S VANICHAKARN.160Membranous glomerulonephritis DJ HARRISON D THOMSON, MARY K MACDONALD.167Coconut matting bezoar identified by a combined analytical approach DA LEVISON, PR CROCKER, TA BOXALL, KJ RANDALL.172Early cellular responses to intradermal injection of Kveim suspension in normal subjects and those with sarcoidosis CS MUNRO, DNMITCHELL, LW POULTER, PJ COLE.176Benign hepatic tumours and tumour like conditions in men PJ KARHUNEN.183Proposed alternative terminology and subclassification of so called "dysplastic naevi" MORAG M SEYWRIGHT, VALERIE R DOHERTY,RONA M maCKIE.189Deficiency ofserum "pregnancy-associated" a2-glycoprotein (a2-PAG): association with disease CHW HORNE, LINDA M GERRIE, SYLVIAARMSTRONG, PW BRUNT NAG MOWAT, TS SINCLAIR.195Dihydropteridine reductase activity in dried blood spots: effects of aging and senile dementia of the Alzheimer type CATHERINE M

SEEPS, ANNE SILCOX, BARBARA LLOYD, BARBARA E CLAYTON.199Role of toxoplasmosis in the aetiology ofsome cardiac diseases: an immunobiological investigation D IIBALIC, C DJURKOVIC-DJAKOVIC 204Rapid diagnosis of Gram negative urinary infections: identification and antimicrobial susceptibility testing in 24 hours CATHERINEM DUPEYRON, GEORGIE A GUILLEMIN, GJ LELUAN.208

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Latex particle agglutination for detecting and identifying Clostridium difficile RA BOWMAN, SUZAN A ARROW, TV RILEY .... ...... 212Clinical importance of Campylobacter pyloridis and associated serum IgG and IgA antibody responses in patients undergoing uppergastrointestinal endoscopy LINDA BOOTH, G HOLDSTOCK, H MaCBRIDE, P HAWTIN, JR GIBSON, A IRELAND, J BAMFORTH, CLAIRE EDUBOULAY, RS LLOYD, AD PEARSON ................................................................................... 215Inhibition of Pseudomonas aeruginosa from cystic fibrosis by selective media K FONSECA, JANE MaCDOUGALL, TL PITT .... ....... 220Detection of group B streptococcal antigen in necropsy specimens using monoclonal antibody and immunoperoxidase staining RGFELDMAN, SM LAW, JR SALISBURY ..................................................................................... 223Technical methodSensitive and rapid measurement of fibrin polymerisation by laser nephelometry A RUIZ-ARGUELLES, BEATRIZ PEREZ-ROMANO .... 227Letters to the Editor............................................................................................... 230Book reviews ................................................................................................. 235Notices ................................................................................................. 235

No 3 MARClH 1986

Working classification of chronic myeloproliferative disorders based on histological, haematological, and clinical findings RBURKHARDT, R BARTL, K JAGER, B FRISCHI, G KETTNER, G MAHL, M SUND .................................................... 237Serum ferritin concentration in sickle cell crisis ALISON BROWNELL, S LOWSON, M BROZOVIC.................................. 253Iron state in alpha and beta thalassaemia trait JM WHITE, R RICHARDS, G JELENSKI, MARGARET BYRNE, M ALI ..... .............. 256Analysis of G banded karyotypes in myeloma cells KUEY-CHU CHEN, PC BEVAN, JG MATTHEWS............................... 260Use of Leu Ml and antiepithelial membrane antigen monoclonal antibodies for diagnosing Hodgkin's disease AS JACK, DCUNNINGHAM, M SOUKOP, CHRISTINE N LIDDLE, FD LEE ................................................................... 267Immunohistochemical analysis ofmononuclear cell subsets in inflammatory and non-inflammatory myopathies NR LEMOINE, JF RYAN,ELAINE L COX, VIVIEN MAYSTON, PA REVELL, M SWASH.....................................................................271Metastatic thymoma: a case report and immunohistological analysis DM SALTER, AS KRAJEWSKI ............................. 275Lamina propria mast cells in biopsies from children with Crohn's disease IR SANDERSON, KBP LEUNG, FL PEARCE, JA WALKER-SMITH 279Poorly differentiated squamous carcinoma of the bronchus: a light and electron microscopic study A CARLILE, C EDWARDS 284Evaluation of strategy for testing thyroid function applied to hypothyroidism CATHRYN M CORNS, AL MILLER................... 293Transitional carcinoma of the upper urinary tract: a histological and cytopathological study WILMA J HIGHMAN .... ........... 297Nature of "basal" and "reserve" cells in oviductal and cervical epithelium in man WM PETERS .............................. 306Comparison of the results of asbestos fibre dust counts in lung tissue obtained by analytical electron microscopy and lightmicroscopy FD POOLEY, DL RANSON ................................................................................. 313Restriction enzyme analysis ofcytomegalovirus DNA to study transmission of infection CATHERINE S PECKHAM, AJ GARRETT, KS CHIN,PM PREECE, DB NELSON, DIANE E WARREN .............................................................................. 318Antigenic specificity of serological response in Chlamydia trachomatis urethritis detected by immunoblotting R CEVENINI, FRUMPIANESI, V SAMBRI, M LA PLACA................................................................................... 325Serotyping of Streptococcus pneumoniae strains by coagglutination LE SMART ............................................. 328Micromodification of Serodia HBe haemagglutination kit and modification of kit to test for anti-HBe PA NUTTALL............ 332Technique for the culture and direct sensitivity of large numbers of urine specimens P CHEETHAM, SE BROWN ..... ............. 335Technical methodsMaking poster demonstrations with word processors HB HELLQUIST ..................................................... 338Plastic processing of cemented hip joint replacement specimens CD PALLETT, WHB MAWHINNEY, AJ MALCOLM ..... ............. 339Letters to the Editor............................................................................................... 342Book reviews ................................................................................................. 347Notices ................................................................................................. 352

No 4 APRIL 1986

Review articleCampylobacter pyloridis, gastritis, and peptic ulceration CS GOODWIN, JA ARMSTRONG, BJ MARSHALL ..... ..................... 353Strongyloides stercoralis hyperinfestation syndrome with Escherichia coli meningitis: report of two cases LESLEY A SMALLMAN,JENNIFER A YOUNG, WR SHORTLAND-WEBB, MP CAREY, J MICHAEL .......................................................... 366Coagulase production by strains of Staphylococcus aureus of differing resistance characters: a comparison of two traditional methodswith a latex agglutination system detecting both clumping factor and protein A JANET IS DICKSON, RR MARPLES................ 371Interactions between polymorphonuclear leucocytes, Bacteroides sp, and Escherichia coli: their role in the pathogenesis of mixedinfection WAC VEL, F NAMAVAR, AMJJ VERWEIJ-VAN VUGHT, ANB PUBBEN, DM MacCLAREN .................................... 376Sudden infant death and cytomegalovirus inclusion disease S VARIEND, RG PEARSE ......................................... 383DNA content and the adenoma-carcinoma sequence in the colorectum HS GOH, JR JASS .................................... 387Value of mucin histochemistry in follow up surveillance of patients with long standing ulcerative colitis JR JASS, JANET ENGLAND, KMILLER.~~~~~~~~~~~~~~~~~~~~~~~~~~~~393MILLER ........ ............ .. .... ... .... ... ... ................39

Monoclonal antibody (UCHLI) that recognises normal and neoplastic T cells in routinely fixed tissues AJ NORTON, AD RAMSAY, SUSANH SMITH, PCL BEVERLEY, PG ISAACSON ................................................................................. 399Morphometric study of histological changes in sublabial salivary glands due to aging process PCM DE WILDE, JPA BAAK, JC vanHOUWELINGEN, L KATER, PJ SLOOTWEG ................................................................................ 406Somatostatin and adrenocorticotropic hormone like immunoreactivity in small cell carcinoma of the lung MF CHRETIEN, APOUPLARD-BARTHELAIX, MP DUBOIS, C SIMARD, A REBEL ........................................................... 418Sear adenocarcinoma of the lung: a light and electron microscopic study C EDWARDS, A CARLILE ............................ 423

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Immunohistochemical detection of ras oncogene p21 product in benign and malignant mammary tissue in man ANNA K GHOSH, MMOORE, M HARRIS .................................................................................................. 428Epithelial membrane antigen and cytokeratin expression by meningiomas: an immunohistological study JM THEAKER, KC GATTER, MMESIRI, KA FLEMING ................................................................................................ 435Peritoneal cystic mesothelioma: an electron microscopic and immunohistochemical study of two male patients IK SIENKOWSKI, AJRUSSELL, SA DILLY, B DJAZAERI....................................................................................... 440Sarcoidosis of the breast S BANIK, PW BISHOP, LP ORMEROD, TEB O'BRIEN .................................................. 446Wash off liver cytology: a complementary diagnostic tool to liver biopsy W VOGEL, EA FAGAN, A BOMFORD, B PORTMANN, R WILLIAMS 449Benign and malignant (B cell) focal lymphoid aggregates in bone marrow trephines shown by means of an immunogold-silvertechnique G SANGSTER, J CROCKER, P NAR, MJ LEYLAND................................................................. 453Technical methodsLatex agglutination method for IgA deficiency used for large scale screening of blood donor sera GR BARCLAY, JM GALL, J GILLON,PL YAP................................................................... .........................................458PLP fixation for combined routine histology and immunocytochemistry of liver biopsies F BRENES, S HARRIS, MOA PAZ, LM PETROVIC,PJ SCHEUER ....................................................................................................... 459Letters to the Editor................................................................................................ 463Book reviews ................................................................................................ 465Notices ................................................................................................ 468

No 5 MAY 1986

Kaposi's sarcoma in acquired immune deficiency syndrome (AIDS) ND FRANCIS, JM PARKIN, J WEBER, AW BOYLSTON .... ....... 469Histometry of normal thyroid in man RA BROWN, M AL-MOUSSA, J SWANSON BECK ......................................... 475Histometry of thyroids containing few and multiple nodules M AL-MOUSSA, J SWANSON BECK ................................ 483Value of cytoprognostic classification in breast carcinomas JACQUELINE MOURIQUAND, M GOZLAN-FIOR, D VILLEMAIN, Y BOUCHET, JCSAGE, MA MERMET, M BOLLA ......................................................................................... 489Malignant epithelial tumours associated with autoimmune sialadenitis PD JAMES, 10 ELLIS................................... 497Approaches to the demonstration of congenital heart disease GA RUSSELL, PJ BERRY ....................................... 503New look at mesoblastic nephroma HB MARSDEN, WA NEWTON INR ...................................................... 508Diagnosing tumours on routine surgical sections by immunohistochemistry: use of cytokeratin, common leucocyte, and othermarkers RN POSTON, YS SIDHU...................................................................................... 514Reflux gastritis: distinct histopathological entity? MF DIXON, HJ O'CONNOR, ATR AXON, RFJG KING, D JOHNSTON .... ............. 524Campylobacter like organisms and reflux gastritis HJ O'CONNOR, JI WYATT, MF DIXON, ATR AXON ............................. 531Isolation and characterisation of intestinal spirochaetes DS TOMPKINS, SALLY J FOULKES, PGR GODWIN, AP WEST .... ............ 535Prognostic importance of DNA flow cytometry in non-Hodgkin's lymphomas JC MACARTNEY, RS CAMPLEJOHN, JULIE ALDER, MGSTONE, GILL POWELL ................. 542Reactivity of T lymphotropic retrovirus antibody (12/1-2) in man: comparison of epidermis with other epithelial cells ELISABETHRALFKIAER, KAREN AF PULFORD, KC GATTER, GUNHILD LANGE WANTZIN, DY MASON........................................... 547Immunocytochemical characterisation ofcutaneous lymphomas other than mycosis fungoides ELISABETH RALFKIAER, TA SAATI, J BOSQ,G DELSOL, KC GATTER, DY MASON .................................................................................... 553Presence of 3-fucosyl-N-acetyllactosamine shown by monoclonal antibody AGF 4-48 in Reed-Stemnberg cells I CROCKER, N SKILBECK,G BROWN, C BUNCE ................................................................................................ 564

Crystal structure of Auer rods in acute myeloblastic leukaemia (AMyL) EC PEARSON ...................................... 569Reference ranges for serum C4 concentrations in subjects with and without C4 null alleles G UKO, FT CHRISTIANSEN, RL DAWKINS, VJMCCANN.......................................................................................................... 573Technical methodCervical brush biopsy specimens suitable for DNA and oncoprotein analysis using flow cytometry J ELIAS-JONES, P HENDY-IBBS, HILARYCOX, GI EVAN, JV WATSON........................................................................................... 577Letters to the Editor............................................................................................... 581Book reviews ................................................................................................ 583Notices ................................................................................................ 584

No 6 JUNE 1986

Lymphocytic infiltration and survival in rectal cancer JR JASS........................................................... 585New approach to assessing lung tumours in man KC GATTER, MS DUNNILL, J GERDES, H STEIN, DY MASON...................... 590Comparison of right ventricular weight at necropsy in interstitial pulmonary fibrosis and in chronic bronchitis and emphysema GEPACKE, RM CAYTON, CW EDWARDS.................................................................................... 594Mast cell sarcoma of the larynx H-P HORNY, MR PARWARESCH, E KAISERLING, K MULLER, M OLBERMANN, K MAINZER, K LENNERT. . 596Morphometry and breast cancer II. Characterisation of breast cancer cells with high malignant potential in patients with spread tolymph nodes: preliminary results HC VAN DER LINDEN, JPA BAAK, J LINDEMAN, J HERMANS, CJLM MEYER........................ 603Demonstration of carcinoembryonic antigen (CEA) expression in normal, chronically inflamed, and malignant pancreatic tissue byimmunohistochemistry WH ALLUM, HJ STOKES, F MACDONALD, JWL FIELDING............................................... 610Monoclonal antibody to macrophages (EMB/l 1) labels macrophages and microglial cells in human brain MARGARET M ESIRI, J O'DMCGEE ......................................................................................................... 615

Comparison of manual data coding errors in two hospitals PA HALL, NR LEMOINE ......................................... 622

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Abnormal steroid excretion in gestational trophoblastic disease complicated by ovarian theca-lutein cysts BR BEVAN, M SAVVAS, JMJENKINS, KARINE BAKER, GW PENNINGTON, NF TAYLOR ................................................................... 627Serum amyloid A concentrations during the course of acute ischaemic heart disease RUTH SHAINKIN-KESTENBAUM, Y WINIKOFF, NCRISTAL .......................................................................................................... 635Serum immunoreactive trypsin and pancreatic lipase in primary biliary cirrhosis V FONESCA, 0 EPSTEIN, A KATRAK, D JUNGLEE, DPMIKHAILIDIS, N MCINTYRE, P DANDONA ................................................................................ 638Influence of urinary sodium excretion on the clinical assessment of renal tubular calcium reabsorption in hypercalcaemic man SHRALSTON, MD GARDNER, FJ DRYBURGH, RA COWAN, IT BOYLE ............................................................ 641Raised hepatic free fatty acids in a patient with acute fatty liver after gastric surgery for morbid obesity SR CAIRNS, AE KARK, TJ PETERS 647Vitamin D nutrition in pregnant Nigerian women at term and their newborn infants F OKONOFUA, S HOULDER, J BELL, P DANDONA 650Biochemical and cultural characteristics of "JK" coryneforms R BAYSTON, J HIGGINS....................................... 654Comparison of radiometric and gas capture system for blood cultures ANNA KING, G BONE, I PHILLIPS........................ 661Kit systems for identifying Gram negative aerobic bacilli: report of the Welsh Standing Specialist Advisory Working Group inMicrobiology CHN BENNETT, DHM JOYNSON........................................................................... 666Technique for measuring 50% end points in cytotoxicity assays for Clostridium difficile toxins SARA W ROTHMAN .... .......... 672Myelofibrosis complicated by intestinal extra-medullary haemopoiesis and acute small bowel obstruction S MACKINNON, AM MCNICOL,FD LEE, GA MCDONALD............................................................................................. 677Comparison of passive haemagglutination test with Widal agglutination test for serological diagnosis of typhoid fever in an endemicarea YM COOVADIA, V SINGH, RH BHANA, N MOODLEY................................................................... 680Distribution of immunoglobulin G subclasses in anti-A and anti-B sera LA KAY, DE LOCKE ................................. 684Technical methodEvaluation of lymph node imprint in rapid diagnosis of lymph node biopsy specimens SA ADEMILUYI, 00 AKINYANJU, VPN MORDI 688Letters to the Editor............................................................................................... 690Book reviews ................................................................................................. 698Notices ................................................................................................. 700

No 7 JULY 1986

Review articleLaboratory investigation of platelet function: a review of methodology DA YARDUMIAN, IJ MACKIE, SJ MACHIN .... ............. 701Autoimmunity in chronic lymphocytic leukaemia TJ HAMBLIN, DG OSCIER, BJ YOUNG ....................................... 713Erythrocyte radiolabelling: in vitro comparison of chromium, technetium, and indium in undamaged and heat damaged cells AMPETERS, S OSMAN, HJ REAVY, B CHAMBERS, M DEENMAMODE, SM LEWIS ....................................................... 717Effects of hyperglycaemia and sorbitol accumulation on erythrocyte deformability in diabetes mellitus D BAREFORD, PE JENNINGS, PCWSTONE, S BAAR, AH BARNETT, i STUART ................................................................................ 722Myelodysplastic syndrome coexisting with acute lymphoblastic leukaemia AN STARK, CS SCOTT, B BHATT, BE ROBERTS .... ....... 728Distribution of immunoglobulin heavy chains in diseased synovia AJ FREEMONT, C RUTLEY.................................. 731Study of childhood renal tumours using peroxidase conjugated lectins S KUMAR, T CARR, HB MARSDEN, PH MORRIS-JONES .... .... 736Histogenesis of Kaposi's sarcoma in patients with and without acquired immune deficiency syndrome (AIDS) R RUSSELL JONES, JSPAULL, C SPRY, E WILSON JONES ......... ........................................................................I.... 742Prostatic adenocarcinoma evolving into carcinoid: selective effect of hormonal treatment? M STRATTON, DJ EVANS, IA LAMPERT 750Metastasising pilar tumour of scalp PA BATMAN, HJR EVANS ............................................................ 757Inflammatory pseudotumour of the liver PP ANTHONY, PU TELESINGHE ................................................... 761Analysis of abnormalities in pituitary gland in non-missile head injury: study of 1,00 consecutive cases CG HARPER, D DOYLE, J HUMEADAMS, DI GRAHAM ............................................................................................. 769Cerebral and orbital Aspergillus infection due to invasive aspergillosis of ethmoid sinus J LOWE, J BRADLEY ..... .............. 774Improved serodiagnosis of tuberculosis using two assay test E KRAMBOVITIS, M HARRIS, DTD HUGHES.......................... 779Pancreatic endoproteases and pancreatic secretory trypsin inhibitor immunoreactivity in human Paneth cells M BOHE, A BORGSTROM,C LINDSTR6M, K OHLSSON .78............................................................................................786Serum amyloid A (SAA) variations in patients with cancer: correlation with disease activity, stage, primary site, and prognosis HBIRAN, N FRIEDMAN, L NEUMANN, M PRAS, R SHAINKIN-KESTENBAUM ........................................................ 794Constructing a database for low cost identification of Gram negative rods in clinical laboratories P CLAYTON, RKA FELTHAM, CJMITCHELL, PHA SNEATH ............................................................................................. 798Patients with suspected myocardial infarction: their test request patterns for clinical biochemistry in a British and a Canadian cardiaccare unit AR HENDERSON, MARY D GARDNER ........ .................................................................. 803Technical methodRapid method for the concentration of hepatitis B virus particles using Beckman airfuge HELEN M MILBORROW, LESLIE BURNETT, SBUNTY LOWE, BN NIGHTINGALE, YVONNE E COSSART...................................................................... 808Letters to the Editor............................................................................................... 810Book reviews ................................................................................................. 814Notices.. 816

No 8 AUGUST 1986

Costing clinical biochemistry services as part of an operational management budgeting system EF TARBIT .....................Mailbox: program designed to improve communication in clinical laboratories JANE F LOUGHLIN, IF TUCKERMAN, AR HENDERSON.

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Isoelectric points of urinary light chains in myelomatosis: analysis in relation to nephrotoxicity EA JOHNS, R TURNER, EH COOPER, ICMMACLENNAN ...... . . . ............................................................................................... 833

Calcium homeostasis in second trimester fetuses CF MONIZ, KH NICOLAIDES, C TZANNATOS, CH RODECK........................ 838Estimations of serum arabinitol for diagnosing invasive candiosis AG DEACON ............................................ 842Serial concentrations of C-reactive protein as an indicator of urinary tract infection in patients with spinal injury A GALLOWAY, HTGREEN, JJ WINDSOR, KK MENON, BP GARDNER, KR KRISHNAN .............................................................. 851

Opsonic activity of intravenous immunoglobulin preparations against Staphylococcus epidermidis LA CLARK, CSF EASMON ....... 856Isolation of Clostridium difficile from human jejunum: identification of a reservoir for disease? GP TESTORE, F NARDI, S BABUDIERI, MGIULIANO, R DI ROSA, G PANICHI ..................................................................................... 861Local immune response to gastric Campylobacter in non-ulcer dyspepsia JI WYATT, BJ RATHBONE, RV HEATLEY................. 863Identifying non-capsulate strains of Streptococcuss pneumoniae isolated from eyes AA PEASE, CWI DOUGLAS, RC SPENCER......... 871Impaired neutrophil function in intestinal lymphangiectasia RP BOLTON, KL COTTER, MS LOSOWSKY ........................... 876Studies of erythroblast function in congenital dyserythropoietic anaemia, type I: evidence of impaired DNA, RNA, and proteinsynthesis and unbalanced globin chain synthesis in ultrastructurally abnormal cells SN WICKRAMASINGHE, M1 PIPPARD .... ...... 881Comparative cytochemical study of dipeptidyl aminopeptidase (DAP) II and IV in normal and malignant haemic cells MR KHALAF,PC BEVAN, FGJ HAYHOE ............................................................................................. 891Autoimmunity in chronic liver disease caused by hepatitis delta virus DANIELA ZAULI, CRISTINA CRESPI, FB BIANCHI, A CRAXI, E PISI 897New aid for diagnosing chronic beryllium disease (CBD): laser ion mass analysis (LIMA) W JONES WILLIAMS, D KELLAND....... 900Severe cutaneous reactions to captopril and enalapril; histological study and comparison with early mycosis fungoides PN FURNESS,MJ GOODFIELD, KA MACLENNAN, A STEVENS, LG MILLARD ................................................................. 902

Oxyphil cells in thyroid disease: a uniform change? CH KENDALL, EVA MCCLUSKEY, J NAYLOR, M EAGLES ..... .................. 908Chronic ulcerative colitis complicated by atypical carcinoid tumour SUSAN M DODD........................................ 913Immunoperoxidase labelled antibody staining in differential dignosis of central nervous system haemangioblastomas and centralnervous system metastases of renal carcinomas SUSAN M ANDREW, E GRADWELL ........................................... 917Fractured neck of femur and contralateral intracerebral lesions J MCCLURE, SUSAN GOLDSBOROUGH ........................... 920Technical methodsEffect of formalin pigment removal on peroxidase-antiperoxidase immunoperoxidase technique JULIE MCGOVERN, J CROCKER .... 923Laboratory diagnosis of peritonitis in continuous ambulatory peritoneal dialysis by lysis and centrifugation RC SPENCER, WK AHMAD 925Letters to the Editor............................................................................................... 926Book reviews .................................................................................................. 929Notices... 932

No9 SEPTEMBER 1986

Reviewv articleTerminology in gynaecological cytopathology: report of the Working Party of the British Society for Clinical Cytology DMD EVANS,EA HUDSON, CL BROWN, MM BODDINGTON, HE HUGHES, EFD MACKENZIE, T MARSHALL.......................................... 933Diagnosing Pneumocystis carinii pneumonia by cytological examination of bronchoalveolar lavage fluid: report of 15 cases JENNIFERA YOUNG, JW STONE, RJS MCGONIGLE, D ADU, J MICHAEL.................................................................. 945Human lung tumours may coexpress different classes of intermediate filaments KC GATTER, MS DUNNILL, GNP VAN MUIJEN, DY MASON 950Immunocytochemical study of 18 tumours causing ectopic Cushing's syndrome PJ COATES, I DONIACH, TA HOWLETT, LESLEY H REES,GM BESSER ....................................................................................................... 955New marker for mesothelioma: an immunoperoxidase study A DONNA, PG BETTA, D BELLINGERI, A MARCHESINI................. 961Pulmonary megakaryocytes: "missing link" between cardiovascular and respiratory disease? GK SHARMA, IC TALBOT............ 969Growth fractions in breast cancers determined in situ with monoclonal antibody Ki-67 J GERDES, RJ LELLE, H PICKARTZ, WHEIDENREICH, R SCHWARTING, L KURTSIEFER, G STAUCH, H STEIN .......................................................... 977

Adenomatosis of small intestine: case report T NAKAMURA H KIMURA G NAKANO........................................... 981DNA ploidy patterns and cytokinetics of non-Hodgkin's lymphoma SK JUNEJA, IA COOPER, GS HODGSON, MM WOLF, JC DING, PNJIRONSIDE, RJS THOMAS, JD PARKIN .................................................................................... 987

High proliferative activity of Reed Sternberg associated antigen Ki-l positive cells in normal lymphoid tissue J GERDES, RSCHWARTING, H STEIN ............................................................................................... 993

French American British (FAB) morphological classification of childhood lymphoblastic leukaemia and its clinical importance isLILLEYMAN, IM HANN, RF STEVENS, OB EDEN, SM RICHARDS ................................................................ 998

Hageman factor, high molecular weight kininogen, and prekallikrein in chronic liver disease C CORDOVA, F VIOLI, C ALESSANDRI, DFERRO, M SALIOLA, F BALSANO........................................................................................ 1003Antimicrobial susceptibility testing of Haemophilus influenzae: trial organised as part of United Kingdom national external qualityassessment scheme for microbiology JJS SNELL, DFJ BROWN, T PHUA......................................................1006Asymptomatic carriage of Clostridium difficile in patients with cystic fibrosis SL PEACH, SP BORRIELLO, H GAYA, FE BARCLAY, AR WELCH 1013Parvovirus infection associated with aplastic crisis in a patient with HEMPAS NC WEST, RE MEIGH, M MACKIE, Mi ANDERSON..... 1019Septicaemia and meningitis caused by dysgonic fermenter-2 (DF-2) PCY CHAN, K FONSECA.................................. 1021Quantitative method for determining serum alkaline phosphatase isoenzyme activity I. Guanidine hydrochloride: new reagent forselectively inhibiting major serum isoenzymes of alkaline phosphatase MDS SHEPHARD, Mi PEAKE............................. 1025Quantitative method for determining serum alkaline phosphatase isoenzyme activity II. Development and clinical application ofmethod for measuring four serum alkaline phosphatase isoenzymes MDS SHEPHARD, MJ PEAKE, RN WALMSLEY.1031

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Technical methodsDetermination of RH(D) genotype: use of human monoclonal antibodies in flow cytometry M KORNPROBST, PH ROUGER, D GOOSSENS,F CHAMPOMIER, CH SALMON.......................................................................................... 1039Simple reagent modification of technicon H6010C that permits processing of uraemic samples BK SMITH, DJ NICHOL, RE DAVIS ... 1040Letters to the Editor............................................................................................... 1042Book reviews ................................................................................................. 1047Notices ................................................................................................. 1048

NolO OCTOBER 1986

Review articleExamination of products of conception terminated after prenatal investigation S KNOWLES ................................. 1049Human and viral gene detection in routine paraffin embedded tissue by in situ hybridisation with biotinylated probes: viral localisationin herpes encephalitis J BURNS, DRM REDFERN, MM ESIRI, JO'D MCGEE...................................................... 1066Histological pattern and changes in extracellular matrix in aortic dissections H SARIOLA, T VILJANEN, R LUOSTO .... ............ 1074Macrophages and mast cells in chronic cholecystitis and "normal" gall bladders I HUDSON, D HOPWOOD...................... 1082Colorectal goblet cell sialomucin heterogeneity: its relation to malignant disease K SUGIHARA, JR JASS ..... ................... 1088Measuring S100 protein and neurone specific enolase in melanocytic tumours using video image analysis RA WILLIAMS, J RODE, APDHILLON, LR JARVIS, JM SKINNER, 0 JAMAL ............................................................................. 1096Malignant eccrine poroma: report of three cases JF RYAN, CR DARLEY, DJ POLLOCK ........................................ 1099Plasma cell granuloma of the thyroid KW CHAN, GP POON, CH CHOI ..................................................... 1105Recognition of protein apparently specific to odontogenic keratocyst fluids CWI DOUGLAS, GT CRAIG ..... .................... 1108Non-tropical pyomyositis I MUSCAT, PP ANTHONY, JG CRUICKSHANK ..................................................... 1116Homology of cryptic plasmid of Neisseria gonorrhoeae with plasmids from Neisseria meningitidis and Neisseria lactamica CATHERINEA ISON, CM BELLINGER, J WALKER..................................................................................... 1119Development of enzyme linked immunosorbent assay (ELISA) to detect antibodies to Pseudomonas aeruginosa cell surface antigensin sera of patients with cystic fibrosis MOIRA M BRETT, ATM GHONEIM, JM LITTLEWOOD, MS LOSOWSKY.......................... 1124Antibody response to anaerobic coccoid rods in Crohn's disease K BULL, N MATTHEWS, J RHODES ............................ 1130Problems with serological diagnosis of Toxoplasma gondii infections in heart transplant recipients TG WREGHITT, JJ GRAY, AH BALFOUR 1135Use of microcomputer to help teach pathology MC ANDERSON, DW FORD ................................................. 1140Hypercalcaemia in T cell acute lymphoblastic leukaemia; report of two cases MA LAFFAN, JG TALAVERA, D CATOVSKY ........... 1143Immune haemolytic anaemia and nomifensine treatment in north west England 1984-85; report of six cases VANESSA JOAN MARTLEW 1147Assessment of new radioimmunoassay kit for determining urinary albumin at low concentrations: comparison with radialimmunodiffusion GF WATTS, JDM ALBANO, JE BENNETT, RW MORRIS, KM SHAW, A POLAK ..................................... 1151Technical methodsNew micro method for deoxyuridine suppression test AC PETTY, JF BURMAN .............................................. 1155Use of high speed centrifugation in early detection of bacteraemia AW STURM ............................................ 1157Letters to the Editor............................................................................................... 1158Book reviews ................................................................................................. 1162Notices.................................................................................................. 1163

No I I NOVEMBER 1986

Expression of blood group antigens in urinary tract tumours: prospective fluorescence study using cryostat sections of fresh frozentissue SUSAN J THORPE, P ABEL, D HENDERSON, NICOLA JONES, TEN FEIZI ................................................... 1165Histological and immunocytochemical study of cervical intraepithelial neoplasia (CIN) with associated HPV 6 and HPV 16infections D JENKINS, SK TAY, DJ MCCANCE, MJ CAMPION, PK CLARKSON, A SINGER ........................................... 1177IgA deposition in alcoholic liver disease RD GOLDIN, SALLY CATTLE, AW BOYLSTON ......................................... 1181Antineuron specific enolase staining reactions in sarcomas and carcinomas: its lack of neuroendocrine specificity MARY LEADER, MCOLLINS, J PATEL, KRISTIN HENRY..................................................................................... 1186Idiopathic membranous glomerulonephritis: aspects of geographical differences S ABE, Y AMAGASAKI, K KONISHI, E KATO, S IYORI, HSAKAGUCHI ....................................................................................................... 1193Monoclonal antibody binding to congophilic elements in human Alzheimer brain SM MACDONALD, MARGARET M ESIRI .... ...... 1199Effects of age and smoking on intima of muscular pulmonary arteries JUNE M FERNIE, D LAMB .............................. 1204Acute idiopathic interstitial myocarditis: case report with special reference to morphological characteristics of giant cells M TANAKA,R ICHINOHASAMA, Y KAWAHARA, Y ESAKI, K HIROKAWA, K OKISHIGE, Y TANAKA .............................................. 1209Necropsy study of mountaineering accidents in Scotland WA REID, D DOYLE, HG RICHMOND, SL GALBRAITH ..... ............... 1217Necropsy study of infarcts of prostate and prostatic urethra TJ JONES, AJ HOWIE........................................... 1221Hypersensitivity to carbamazepine presenting as pseudolymphoma P YATES, G STOCKDILL, M MCINTYRE ..... .................. 1224Evidence for monoclonal T lymphocyte proliferation in angioimmunoblastic lymphadenopathy NTJ O'CONNOR, JA CRICK, JSWAINSCOAT, KC GATTER, H STEIN, B FALINI, DY MASON .................................................................... 1229Increased a: non-a globin chain synthesis ratios in myelodysplastic syndromes and myeloid leukaemia RE PETERS, ALISON MAY, AJACOBS............................................................................................................ 1233Terminal transferase positive cells in testicular biopsy specimens from boys with acute lymphoblastic leukaemia JUDITH M CHESSELLS,JR PINCOTT, W DANIELS-LAKE ........................................................................................ 1236

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In vitro stimulation of plasminogen activator release from vein walls by adrenaline A KJAELDGAARD, M KJAELDGAARD .... ...... 1241Effects of N-methyl-thiotetrazole cephalosporin on haemostasis in patients with reduced serum vitamin K X concentrations IJ MACKIE,K WALSHE, H COHEN, P MCCARTHY, M SHEARER, SD SCOTT, SJ KARRAN, SJ MACHIN............................................. 1245Serum angiotensin converting enzyme in pneumonias Y KERTTULA, TH WEBER............................................. 1250Importance of anticomplement immunofluorescence antibody titration for diagnosing varicella-zoster virus infection in Bell's palsyS SHIGETA, M BABA, M OGATA, H NOZAKI, A OKUAKI, S NAKAMURA ......................................................... 1254

Novel method for detecting micro-organisms in blood cultures D SAWHNEY, S HINDER, D SWAINE, EY BRIDSON ... ........... 1259Interactive roles of monovalent and divalent cations in pathogenesis of hypertension caused by alcohol FAA ADENIYI ........... 1264Technical methodsSimultaneous demonstration of cyst walls and intracystic bodies of Pneumocystis carinii in paraffin embedded lung sections usingGomori's methenamine silver nitrate and Giemsa stain T SHIOTA........................................................ 1269New method for typing coagulase negative staphylococci JR STEPHENSON, S TABAQCHALI .................................... 1271Letters to the Editor............................................................................................... 1276Book reviews ................................................................................................... 1279Notices.................................................................................................... 1280

No 12 DECEMBER 1986

Review articleDNA analysis in human disease AF WRIGHT ............ ............................................................. 1281Acute transformation of essential thrombocythaemia: report of two cases AM O'HEA, W ERBER, NTJ O'CONNOR, C BUNCH......... 1296Comparison of erythrocyte antioxidative enzyme activities between two types of haemoglobin H disease S PRASARTKAEW, ABUNYARATVEJ, S FUCHAROEN, P WASI ...................................................................................1299Leucocyte elastase activity in meningococcal septicaemia associated coagulopathy D CANAVAN, FLORENCE ROBINSON, P TURKINGTON 1304Immunoblot analysis of serological response to Pseudomonas aeruginosa septicaemia in man RUTH C MATTHEWS, JP BURNIE, STABAQCHALI ...................................................................................................... 1306

Class specific immunoglobulin response to individual polypeptides of Chlamydia trachomatis, elementary bodies, and reticulate bodiesin patients with chlamydial infection R CEVENINI, F RUMPIANESI, M DONATI, A MORONI, V SAMBRI, M LA PLACA .... .............. 1313Immunohistological studies of lymphoproliferative lesions in a fatal case of Epstein-Barr virus infection P MORGAN-CAPNER, JAMORRIS, MB MCILLMURRAY, JA THOMAS, DH CRAWFORD, T AZIM ............................................................ 1317

Immunolocalisation of cathepsin D in normal and neoplastic human tissues WA REID, MJ VALLER, J KAY...................... 1323Glycoprotein abnormalities in colonic carcinomata, adenomata, and hyperplastic polyps shown by lectin peroxidasehistochemistry JM RHODES, RR BLACK, A SAVAGE ....... ............................................................... 1331

Use of immunocytochemical staining to identify cells in peritoneal fluid and washings at laparoscopy and laparotomy ANNA K GHOSH,Al SPRIGGS, M CHARNOCK ........................................................................................... 1335

Morphometric data to FIGO stage and histological type and grade for prognosis of ovarian tumours JPA BAAK, ECMWISSE-BREKELMANS, FA LANGLEY, A TALERMAN, JFM DELEMARRE ........................................................... 1340

Morphometry of spermatozoa using semiautomatic image analysis JR JAGOE, NP WASHBROOK, ELIZABETH A HUDSON .... ........ 1347Nuclear diameter in parathyroid carcinomas JM JACOBI, HM LLOYD, JF SMITH.............................................. 1353Endocrine variant of ductal carcinomas in situ of breast: ultrastructural and light microscopical study MT ASHWORTH, MT HAQQANI 1355Technical methodDipstick analysis for screening of paediatric urine PC BORELAND, MAUREEN STOKER ........................................ 1360Letters to the Editor............................................................................................... 1363Book reviews ................................................................................................... 1365Notices.................................................................................................... 1367List of Assessors .................................................................................................. 1369Annual Author index to Volume 39 ................. ................................................................ 1370Annual Subject index to Volume 39................................................................................. 1375Annual Contents to Volume 39..................................................................................... 1389

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