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Curriculum Vitae
Jose F. Caro, M.D.
Artist Dis/nguished Professor of Medicine Emeritus
General Informa/on
Home Address: 5947 McKinges Circle Carmel, IN 4603 Telephone: 252-‐414-‐1738 Email: [email protected] webs: www.josefcaro.com www.linkedin.com/in/josefcaro Birthplace: Granada, Spain; June 27, 1948 CiUzenship: USA Marital Status: Married with Marice E. Caro for 42 years Children: Maricelina, Rodolfo, Marina and Rafael Grand Children: Olivia, Elise, Bridget, Julia and Julian
Summary
Jose F. Caro began a new career in art in 2008. He went back to college to pursue a degree in fine art and is having his pastel paintings peer reviewed by his colleagues. Before this transformation he was the Vice President of Endocrine Research and Clinical Investigation and Global Diabetes Care at Eli Lilly & Comp for 12 years. Prior to joining Lilly he was the Magee Professor of Medicine and Chairman of the Department at Jefferson Medical College for 5 years and the Chief of Endocrinology and Director of the University Diabetes Center at East Carolina University for 10 years.
Dr. Caro received his M.D. degree with honors in 1973 from the School of Medicine in Madrid, Spain and Montevideo, Uruguay. He completed residency and fellowship training at Jefferson Medical College and at the University of Rochester. He is Board Certified in Internal Medicine and Endocrinology and Metabolism.
Dr. Caro was a member of various professional and honorary societies, including the American Society for Clinical Investigation (Young Turk) and the Association of American Physicians (Old Turk). He was the recipient of the Medal of Honor and is an honorary member of the Real Academy of Medicine of Granada, Spain. He is the Honorary Director of the Peking Diabetes Center and Honorary Professor of the Peking University Health Science Center in China.Dr.
He has authored about 200 papers, book chapters and books and he was recently listed as the third most highly cited investigator in the world in the field of Obesity Research by ISI. He served as Editor and Editorial Board member of several journals and has lectured around the world. Dr. Caro has served as a member and Chairman of several study sections at the NIH and more recently as a member of the NIDDK Advisory Council to the President.
He lives in Carmel IN with Marice, his spouse for 42 years. His main artistic inspiration is his family...his four children and five grandchildren.
________________________ART_______________________________
Why a Second Career in Art?
My great granduncle, Rafael Eiroa, was an artist in the late XIX century Spain. One of his paintings was in my parents’ home. It was a middle age woman sitting in a dilapidated straw chair. Her eyes were unfixed and gazed into space. It was almost as if she was waiting to catch the opportunity she did not have. Every night I fell to sleep thinking about her, about opportunities, the future, and most definitively that I wanted to paint like my uncle Rafael.
After the Spanish Civil war, my family like many others immigrated to Argentina looking for the freedom they did not have. I still remember vividly those 21 days crossing the ocean aboard the steamship Buena Esperanza (Good Hope). My great granduncle’s large canvas was carefully removed from the frame by my father, rolled and stored into a trunk labeled “memories from Spain”.
Many years had passed before my mother decided to open the trunk. The canvas was severely damaged. I was a teenager and had forgotten the woman sitting in a chair. Nevertheless, my parents knowing my interest for art suggested that I repair her. I bought oils and brushes and I did it! I knew then what I wanted to become. But when I told my father about my desire to enter the school of art he said “study son, you will always have time to paint”.
I became a physician and soon after graduation I moved to the USA with my wife and daughter looking for freedom and opportunities, like my parents did. It has been a great 40 years journey but I never found time to paint like my father said. Thus, I left medicine and science at age 60 to find time to paint. My youngest son Rafael after reading this statement he smiled and firmly said “I will start a career in art this fall semester”. If I finish wanting to paint like my uncle Rafael and my son Rafael, I would say it is not a bad way to end.
Presentations at Juried Shows.-
2009 Greenville Museum of Art Annual Juried Show. Greenville, NC “Only in California” and “The Magic Five Minutes in the Morning”
2011 Pastel Society of North Carolina, Winter Exhibition. Greensboro, NC “The Beach at Acadia National Park”
2013 Ninth Annual Northeast National Pastel Exhibition, Old Forge, NY “I am not a little girl anymore”
2013 27th Annual International Exhibit. Northwest Pastel Society. Tacoma, WA “At Acadia National Park”
2013 First Carteret County Juried Art Show. Emerald Isle, NC “Shall I grow up?” and “At the Poconos Mountains”
2013 North Carolina Statewide Juried Pastel Exhibition. On Common Grounds: Pastel Paintings From The Mountains To The Sea. “I am not a little girl anymore”
2013 The 23rd International Association of Pastel Societies Juried Exhibition. Marshfield, MA “I am not a little girl anymore”
2014 The Southeastern Pastel Society’s 16th International Exhibition. Oglethorpe University Museum of Art. Atlanta, GA “I am Not Alone” and “Dreaming About Spring”
2014 28th Annual International Exhibit. Northwest Pastel Society. Tacoma, WA “At Acadia National Park”
2014 Northeast National Pastel Exhibition, View.Old Forge NY “Maternity”
2014 Degas Pastel Society Fifteenth Biennial National Exhibition. New Orleans, LA. “Maternity” and “I am not alone”
2014 Southeastern Pastel Society On-Line Juried Exhibition. “Choices”
2015 Pastel Society of the West Coast 2015 Annual Members Show. Haggis Museum, Stockton, CA. “I am not alone”
2015 Southeastern 2015 juried members exhibition. Quinlan Visual Art Center, Gainesville, GA. “Maternity”
2015 Degas Pastel Society Nineteenth Membership Exhibition. New Orleans, LA “Choices” and “I am not a little girl anymore”
2015 The Peninsula Art League 2015 Open Juried Show. Harbor History Museum, Gig Harbor, WA “Maternity” and “The hug” One Person Shows.-
2013 Emerald Isle Recreation Center, Emerald Isle, NC
2013 Bogue Banks Public Library, Pine Knoll Shores, NC
2013 Arts for the Hospital, Carteret Hospital, Morehead City, NC
Presentations at Non Juried Shows.-
2013 Art for the Heart Annual Exhibition. Carteret County Art Council. Morehead City, NC . “I am not a little girl any more” and “The beach at Emerald Isle”
Awards/Honors/Publications.-
2012 The Editor Choice: “Celebration of Water”. Art & Beyond Vol. 6, page 16, 2012.
2013 Juried Associate Member of the Pastel Society of America (PSA)
2013 Featured Artist of the Week with “Are we ready to leave home” at Artists Registry.com
2013 Featured Artwork @The Library. The Shoreline, Vol. 9, No. 8, p. 10
2013 Featured Pastel Artist. News-Time, Vol. 102, No.59, p.
2013 News and Mentions. Art Line, Pastel Society of NC. Vol. 2013 May
2014 The Artist’s Magazine. Annual Art Competition. Portrait/Figure Third Place Winer “I am not a little girl anymore”
2015 Juried Full Member of the Degas Pastel Society.
2015 Juried Full Member Indiana Artists Club
Professional Societies and Memberships.-
2008 - 2012 The Indiana Art Association
2009 - Present Hoosier Salon, Patron Association and Fine Art Gallery 2009 - 2012 Northern Indiana Pastel Society
2012 - 2014 Craven Arts Council & Gallery, Inc., NC
2012 - 2014 Seaside Arts Council, NC
2012 - 2014 Art Council of Carteret County, NC 2012- 2014 Pastel Society of North Carolina
2012- 2014 Greenville Museum of Art, NC
2013- Present Juried Associate Member Pastel Society of America (PSA)
2013- Present Northwest Pastel Society
2014- Present Southeastern Pastel Society
2014 - Present Juried member of the Degas Pastel Society
Invited Lectures. -
“The role of art in society”. Lookout Rotary Club, Morehead City, NC 2012
“The Past and Present of Pastel Painting”. At the Art for the Hospital Annual Meeting.Carteret Community Hospital, Morehead City, NC 2013
Consultant/Advisory Activities. -
Member of the Board of Arts for the Hospital. Carteret County Community Hospital, Morehead City, NC
Member of the Jury for Arts for the Heart, Student Category, Carteret County Art Council, Morehead City, NC
Art education.-
2008-2010 Semester Courses in Fine Art at the Indianapolis Art Center.
2010-2012 Study Fine Art at CCC College, Morehead City, NC
2011-Present Participation at Workshops, critic sections and art classes with experience artists such us W. Creevy, R. McKinley, P. Newell.
_______________________MEDICINE_____________________
MEDICAL EDUCATION
1967 -‐ 1973 School of Medicine, Universidad Autonoma de Madrid, Spain and School of Medicine, Universidad de la Republica, Montevideo, Uruguay
POSTGRADUATE TRAINING
1974 -‐ 1977 Residency in Internal Medicine, Thomas Jefferson University Hospital of Thomas Jefferson University, Philadelphia, Pennsylvania
1977 -‐ 1978 Fellowship in Internal Medicine, Thomas Jefferson University Hospital of Thomas Jefferson University, Philadelphia, Pennsylvania
1978 -‐ 1981 Fellowship in Endocrinology and Metabolism, Strong Memorial Hospital, University of Rochester School of Medicine and DenUstry, Rochester, New York
CERTIFICATIONS
1979 Board CerUficaUon in Internal Medicine, American Board of Internal Medicine
1984 Board CerUficaUon in Endocrinology and Metabolism, American Board of Internal Medicine
APPOINTMENTS
1981 -‐ 1983 Assistant Professor of Medicine, Endocrinology and Metabolism, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania
1983 -‐ 1986 Associate Professor of Medicine, SecUon Head of Endocrinology and Metabolism, East Carolina University School of Medicine, Greenville, North Carolina
1986 -‐ 1991 Professor of Medicine, SecUon Head of Endocrinology and Metabolism and Director of the University Diabetes Center, East Carolina University School of Medicine, Greenville, North Carolina
The Division of Endocrinology and Metabolism was founded. Six faculUes were recruited
and mentored and all became funded by the NIH. A comprehensive Fellowship Program
was approved. The ECU Diabetes and Obesity Center was established. Dr. J. F. Caro became Program Director of the “ECU Diabetes Program Project”, the largest NIH award in the history of the University. Basic research discoveries were made such as mechanism(s) of IRTK defects in liver, muscle and liver from humans with diabetes and clinical research observaUons were made such as that the gastric bypass surgery prevent diabetes by 40 folds in people with pre-‐diabetes and reverse diabetes in more than 80 percent of paUents for more than 10 years.
1991 -‐ 1996 Magee Professor of Medicine and Chairman of the Department, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania
The Department of Medicine tripled its NIH funding and moved from the middle third to the upper third of NIH ranking. The residency program became the largest in the State with most house staff elecUng a career on primary care. Out paUent encounters tripled and hospital’s paUent duraUon of hospitalizaUon decreased by half. The budget of the Department conUnued generaUng overage for program development. All this was achieved without a significant increase in FTEs. This is what our Dean called “producUvity without expansion”
1996 -‐ 2008 Vice President, Endocrine Research and Clinical InvesUgaUon and Vice President of Global Diabetes Care. Lilly Research Laboratories, Eli Lilly & Comp, Lilly Corporate Center, Indianapolis, IN
The focus was on drug discovery from hypothesis generaUon in the laboratory to prove of concept in phase 2 clinical trials. The effort involved a heavily matrix organizaUon with chemistry, toxicology, ADME, biology, clinical pharmacology, markeUng, business, etc. More than 40 compounds were discovered that fulfilled all FDA requirements to enter clinical trials. The endocrine porlolio transformed from only Insulin to a more complete porlolio with several INDs and NDAs sUll in clinical trials from this decade’s drug discovery pipeline.
1996 -‐ 2008 Professor of Medicine, Indiana University School of Medicine Indianapolis, IN
2005 -‐ Present DisUnguished Professor of Medicine, Emeritus, East Carolina University School of Medicine, Greenville, NC
2007 – Present Co-‐Founder, Chief ScienUfic Officer Emeritus and Honorary Member of the ExecuUve Commioee of Peers for Progress. AAFP, University of North Carolina, Chapel Hill, NC
2012-‐Present President and Founder, JFC SoluUons LLC
AWARDS AND RESEARCH GRANTS (direct cost only)
1979 -‐ 1981 Juvenile Diabetes FoundaUon Fellowship Award (P.I.)
($75,000)
1981 -‐ 1983 American Diabetes AssociaUon Wayne Newton Research Grant (P.I.) ($68,750)
1981 -‐ 1982 Small Grant Award PHS Biomedical Research Support Grant 5 S07RR0514, Jefferson Jefferson Medical College (P.I.) ($120,000)
1981 -‐ 1982 Department of Medicine Research Grant, Jefferson Medical College (P.I.) ($12,500)
1981 -‐ 1983 Juvenile Diabetes FoundaUon Research Grant (P.I.) ($110,000)
1982 -‐ 1983 Research Grant, Upjohn Company (P.I.) ($31,250)
1982 -‐ 1985 New InvesUgator Research Award 1 R23AM 30558, NaUonal InsUtutes of Health (PI) ($176,500)
1984 -‐ 1985 Research Grant, 5-‐81011 Years Laboratories (P.I.) ($43,750)
1985 -‐ 1987 Research Grant, Upjohn Company (P.I.) ($50,000)
1985 -‐ 1988 Research Grant, R01-‐AM 32585 NaUonal InsUtutes of Health (P.I.) ($297,000)
1986 -‐ 1990 Research Grant, R01-‐DK 38066 NaUonal InsUtutes of Health (P.I.) (This grant was funded but was inacUvated because of overlap with the Program Project DK 36296
1987 -‐ 1988 Sponsor of Fogerty Fellowship Award from the NaUonal InsUtutes of Health (IF05TW04048) to Dr. Ivan Contreras
1987 -‐ 1992 ECU Diabetes Program Project, P01-‐DK 36296 NaUonal InsUtutes of Health (Program Director)
($2,550,000)
1987 -‐ 1992 Research Grant, Eli Lilly Company (P.I.) ($375,000)
1988 -‐ 1989 Research Grant, Glaxo PharmaceuUcal Company (P.I.) ($62,500)
1988 -‐ 1989 Research Grant, R03-‐DK 41191-‐1 NaUonal InsUtutes of Health (P.I.) ($41,250)
1988 -‐ 1989 Research Grant, Pfizer PharmaceuUcal Company (P.I.) ($30,000)
1989 -‐ 1992 Sponsor of Fellowship Award from the NaUonal InsUtutes of Health (IF32DK08477) to Dr. Jacob Friedman
1990 -‐ 1991 Research Grant, Park Davis PharmaceuUcal Company (P.I.)
1990 Small Grant Award: Roaring VisiUng Professorship Program in Diabetes Management ($6,250)
1990 Research Grant, 1R03-‐DK 2924 NaUonal InsUtutes of Health (P.I.) ($41,250)
1990 -‐ 1992 Research Grant, Amylin PharmaceuUcal Company (P.I.) ($100,000)
1991 -‐ 1993 Sponsor of Fellowship Award to Dr. Bartolome Burguera from the Juvenile Diabetes FoundaUon
1991 -‐ 1992 Research Grant, Hoechst-‐Roussel PharmaceuUcals, Inc. (P.I.) ($62,500)
1992 -‐ 1994 Sponsor of Fellowship Award to Dr. Robert Considine from the NaUonal InsUtutes of Health (IF32DK08888)
1993 -‐ 1994 Research Grant, Eli Lilly Company (P.I.) ($96,015)
1993 -‐ 1994 Research Grant, Eli Lilly Company (Co-‐PI) ($65,235)
1993 -‐ 1995 Research Grant, Amylin PharmaceuUcal, Inc. (P.I.) ($37,676)
1994 -‐ 1995 Research Grant, Miles Laboratories (P.I.) ($153,125)
1994 -‐ 1995 Research Grant, Pfizer PharmaceuUcals (Co-‐Invest.) ($37,500)
1994 -‐ 1996 Research Grant, CI-‐991, Park Davis PharmaceuUcals (Co-‐Invest.) ($47,000)
1992 -‐ 1997 Research Grant, R01-‐DK 44950 NaUonal InsUtutes of Health (P.I) ($1,900,000)
1994 -‐ 2002 Research Grant, UO1-‐DK48468, NaUonal InsUtutes of Health (P.I.) ($3,422,165)
SPECIAL RESEARCH GRANTS
2006-‐2012 Bringing Research In Diabetes Through Environment and Systems (BRIDGES). See Press Release Cape Town, South Africa, 5 December 2006 [email protected] Dr. Caro idenUfied the need of translaUonal research in diabetes at the global level. He wrote a Grant to the Lilly FoundaUon and provided support to the InternaUonal Diabetes FederaUon.
($10,000,000)
2007-‐2012 Peers for Progress. See Press Release Leak wood, KS, USA, June 20, 2007,www.lilly.com/product/acceess/foundaUon, Peersforprogress.org
Dr. Caro idenUfied the need of new methods for paUent educaUon in diabetes. He wrote a Grant to the Lilly FoundaUon and provided support to the American Academy of Family Physicians FoundaUon. Peers for progress will idenUfy and train laid volunteers who have diabetes and empower them to assist other people with diabetes. The goal is to educate one percent of the people with diabetes or two million diabetes to become mentors around the world. The concept was validated at a World Health OrganizaUon consultaUon, 5-‐7 November 2007 in Geneva.
($15,000,000)
HONORS AND NAMED LECTURESHIPS
1986-‐1992 Recipient of the “ Pearl Lecturer” every year while in the Faculty (Senior Medical Students' Teaching Award). East Carolina University School of Medicine, Greenville, NC
1988 -‐2012 Member of the American Society of Clinical InvesUgators (Young Turk)
1991 Outstanding InvesUgator Award. Department of Medicine Fish Annual Research Day, East Carolina University School of Medicine, Greenville, NC, 1991.
1992 Karl Paschkis Lecturer, "NIDDM: Lessons from the Laboratory." The Philadelphia Endocrine Society, Philadelphia, Pennsylvania, 1992.
1993 Bernardo A. Houssay Lecturer, "Insulin Resistance in Type II Diabetes", InternaUonal Diabetes FoundaUon and The Costa Rican AssociaUon of Endocrinology, San Jose, Costa Rica, 1993.
1996 Mithoffer Lecturer, "LepUn: The Tale of an Obesity Gene", Medical University of South Carolina, Charleston, SC, 1996.
1996 Alexander Marble Lecturer, “Obesity: A syndrome of LepUn Resistance”. Joslin Diabetes Center. Harvard Medical School. Boston, Massachuseos, 1996.
1997 BanUng and Best Lecturer: “Discovery of LepUn”. University of Toronto. Canada Diabetes AssociaUon. Toronto, Canada, 1997
1998 Eugene Furth Lecturer “On the trail to cure Diabetes” East Carolina University School of Medicine, Greenville, North Carolina, 1998
1998 A.M. Cohen Memorial Lecturer: “On the Trail to Cure Diabetes”. VII InternaUonal Symposium on Insulin Receptors and Insulin AcUon: Molecular and Clinical Aspects. Jerusalem, Israel, 1998
1998 Recipient of the Medal of Honor and Honorary Membership to the Real Academy of Medicine of Granada. Granada, Spain, 1998
1991 -‐ 2001 The third most highly cited invesUgators in the field of Obesity Research by the InsUtute for ScienUfic InformaUon (I.S.I).
2000 -‐ 2012 Member of the AssociaUon of American Physicians (Old Turk)
2004 -‐ present Honorary Director of the Peking Diabetes Center and Honorary Professor of the Peking University Health Science Center. Peking, China.
2005 The Leslie Nicholas Lecture “The scienUfic Basis of New Therapies for Obesity”. The College of Physicians of Philadelphia, PA
EDITORIAL ACTIVITIES
1988 -‐ 1996 Associate Editor, Advances in Diabetologia
1991 -‐ 1997 Associate Editor, Diabetes Care
1991 -‐ 2002 Editorial Board, Journal of Clinical Endocrinology and Metabolism
1992 -‐ 2002 SecUon Editor, Obesity Research, North American AssociaUon for the Study of Obesity
1994 -‐ 1999 Associate Editor, Medicina y Cultura
1985 -‐ 2008 Associate Editor, Metabolism Clinical and Experimental
2001 -‐2005 SecUon Editor, NutriUon and Obesity, Endotext.com
2004 -‐ 2006 Co-‐Editor, The Metabolic Syndrome at the Beginning of the XXI Century: A GeneUc and Molecular Approach
2005 -‐ 2008 Editorial Board, Journal of Clinical Endocrinology and Metabolism
2005 – 2008 InternaUonal Editorial Board, Obesity and Metabolism
CONSULTANT ACTIVITIES TO NIH
1985 -‐ 1989 Member, Metabolism Study SecUon, NaUonal InsUtutes of ArthriUs, Diabetes and Kidney Diseases. NaUonal InsUtutes of Health
1989 Special Reviewer, Study SecUon for Small Business InnovaUon Research, Pharmacology Panel, NaUonal InsUtutes of Health
1989 Member, Site Visit Team, General Clinical Research Center Commioee. NaUonal InsUtutes of Health
1989 Member, Site Visit Team to review a NIH General Clinical Research Center
1990 Member, Clinical Sciences Study SecUon Site Visit. NaUonal InsUtutes of Health
1991 Member, NIH Site Visit Team, General Clinical Research Center
1992 Member, Special Review Commioee, NaUonal InsUtute of General Medical Sciences, NIH
1992 Member, External Advisory Commioee, Sims' Obesity and NutriUon Research Center, NIDDK and NICHD
1992 Member, NIDDK Special Grant Review Commioee
1992 Chairman, Diabetes Endocrinology Research Center Study SecUon, NIH, Bethesda, Maryland
1992 Member, Site Visit Team, General Clinical Research Center, NaUonal InsUtute of Health
1993 Chairman, Ad Hoc Review Group SSS-‐L Clinical Sciences Review SecUon, NaUonal InsUtute of Health.
1994 Member, Behavioral and Neurosciences Special Emphasis Panel, NIH
1995 Member, Ad Hoc Review Commioee, Diabetes Research and Training Centers, NaUonal InsUtute of Health
1998 Member, Congressionally Mandated Diabetes Research Working Group and Chairman of the Industry/Academia Subgroup, NaUonal InsUtute of Health (NIH).
1996 -‐ 2000 Member, Subcommioee B of the Diabetes and DigesUve and Kidney Diseases Special Grants Review Commioee, NaUonal InsUtute of Diabetes and DigesUve and Kidney Diseases (NIDDK), NIH
2000 -‐ 2004 Member of the NaUonal InsUtute of DigesUves and Diabetes and Kidney Diseases
Advisory Council, NIH and Chairman of the Concurrence Grant Awards Approval Commioee of the NIDDK Advisory Council, NIH
2000 – 2004 Member of the Disease PrevenUon and Management Working Group, Advisory Council of the NaUonal InsUtute of Diabetes and DigesUve and Kidney Diseases, NIH
2000 – 2004 Member of the Advisory Council OperaUng Procedures Working Group, NIDDK Advisory Council, NIH
CONSULTANT ACTIVITIES TO THE AMERICAN DIABETES ASSOCIATION
1984 -‐ 1985 Chairman, PaUent EducaUon Commioee, American Diabetes AssociaUon, North Carolina
1984 -‐ 1985 President, American Diabetes AssociaUon, Pio County Chapter, North Carolina
1985 -‐ 1986 Chairman, PaUent EducaUon Commioee, American Diabetes AssociaUon, North Carolina Affiliate
1988 -‐ 1991 Member, Professional EducaUon Commioee, American Diabetes AssociaUon
1989-‐1991 Member, Commioee on ScienUfic and Medical Profession. American Diabetes AssociaUon
1992 Member, Grant Review Panel, Studies on GeneUcs in NIDDM, American Diabetes AssociaUon, New York, NY.
1989-‐1991 Master Faculty, Clinical EducaUon Program, "Managing Diabetes in the 1990's," American Diabetes AssociaUon.
1990 -‐ 1991 President Elect, American Diabetes AssociaUon, North Carolina Affiliate
1991 -‐ 1992 President, American Diabetes AssociaUon, North Carolina Affiliate
1992 -‐ 1996 Member, Board of Directors, American Diabetes AssociaUon, Pennsylvania Affiliate
1992 -‐ 1996 Member, Professional EducaUon Commioee, American Diabetes AssociaUon, Pennsylvania Affiliate
1993 Panel member, Consensus Development Conference on the Treatment of Hypertension in Diabetes, American Diabetes AssociaUon
1993 -‐ 1996 Member of the Academic Steering Commioee, Professional Diabetes Academy
1994 -‐ 1996 Chairman, ScienUfic and Medical MeeUngs Oversight Commioee of the American Diabetes AssociaUon
1994 -‐ 1996 Member, Professional SecUon Advisory Panel of the American Diabetes AssociaUon
MEDICAL SCHOOL COMMITTEES
1985 -‐ 1986 Member, Policy and Review Commioee on Human Research, East Carolina University
1985 -‐ 1986 Member, House Staff EvaluaUon Commioee, East Carolina University
1985 -‐ 1991 Member, Human Organ Transplant Commioee, East Carolina University
1985 -‐ 1991 Member, Department of Medicine Research Advisory Commioee, East Carolina University
1986 -‐ 1987 Member, RadiaUon Safety Commioee, East Carolina University
1986 -‐ 1987 Member, InsUtuUonal Review Commioee, Pio County Memorial Hospital
1987 -‐ 1988 Member, Dean's Search Commioee (Elected by the Faculty), East Carolina University
1987 -‐ 1991 Member, Jacob Furth Prize Commioee, East Carolina University
1989 -‐ 1990 Chairman, Ad Hoc Commioee, Clinical Research Center, School of Medicine, East Carolina University
1989-‐1990 Member, Ad Hoc Commioee, Medical School Core Laboratory FaciliUes. School of Medicine, East Carolina University
1991 Member, Search Commioee for Chairman of the Department of Medicine (Elected by the faculty), East Carolina University
1995 -‐ 1996 Member, University Advisory Commioee on InternaUonal Affairs, Thomas Jefferson University
1995 -‐ 1996 Secretary, Jefferson Faculty FoundaUon ExecuUve Commioee, Jefferson Medical College
1995 Member, Jefferson Faculty FoundaUon Finance Commioee, Jefferson Medical College
OTHER CONSULTANT/COMMITTEE WORK
1986-‐1996 Ad Hoc Reviewer, Research Grants Program. Veterans AdministraUon, Washington, DC
1988 -‐ 1992 Member of the Medical Science Review Commioee, Juvenile Diabetes FoundaUon InternaUonal
1989-‐1999 Ad Hoc Reviewer, NaUonal Science FoundaUon. Washington, DC
1989-‐1991 Member, Board of Medical Advisors. Amylin CorporaUon, San Diego, CA
1992 -‐ 1996 Member, Board of Trustees, Methodist Hospital, Philadelphia, PA
1992 -‐ 1996 Member, Board of Trustees, Magee RehabilitaUon Hospital, Philadelphia, PA
1992 -‐ 1996 Member, Board of Directors, Philadelphia Endocrine Society
1993 -‐ 1996 Member, Boston Obesity/NutriUon Research Center ScienUfic Advisory Group
1993 -‐ 1994 Member, EducaUon Commioee, Professional Diabetes Academy
1994 -‐ 1996 Member, Academic Advisory Commioee of the Pfizer VisiUng Professorship Program in Diabetes Management
1994 Member, Commioee on Faculty and Researchers, Interamerican College of Physicians and Surgeons
2001 -‐ 2005 Member, JDRF Management Advisory Board
2004 Member, American Obesity AssociaUon Advisory Board
PROFESSIONAL SOCIETIES/MEMBERSHIPS
1976 -‐2010 Member, American Society of Internal Medicine
1977 -‐2010 Member, American College of Physicians
1979 -‐ 2010 Member, American FederaUon for Clinical Research
1980 -‐ 2010 Member, American Diabetes AssociaUon
1980 -‐ 2010 Member, Endocrine Society
1984 -‐ 2010 Member, American AssociaUon for the Advancement of Science
1984 -‐ 2010 Member, American Medical AssociaUon
1984 -‐ 1992 North Carolina Medical Society
1988 -‐ 2010 Member, American Society for Clinical InvesUgaUon (Young Turk)
1991 -‐ 2010 Member, Sigma Xi, The ScienUfic Research Society
1992 -‐ 1997 Pennsylvania Medical Society
1992 -‐ 1997 Philadelphia County Medical Society
1992 -‐ 1997 College of Physicians of Philadelphia
1992 -‐ 2010 Charter Member, American AssociaUon of Clinical Endocrinologists
1993 -‐ 2010 Fellow, American College of Physicians
1993 -‐ 2010 Member, North American AssociaUon for the Study of Obesity
1993 -‐ 2010 Member, Professional Diabetes AssociaUon
1995 -‐ 2010 Member, Society of Ibero LaUn American Medical Professionals
1996 -‐ 1997 Member, American Society for Clinical Pharmacology and TherapeuUcs
2000 -‐ 2010 Member, AssociaUon of American Physicians (Old Turk)
SPECIAL POST GRADUATE EDUCATION
1992 Program for Chiefs of Clinical Services, Harvard School of Public Health
1993 Program for ExecuUves in Managed Care, Harvard School of Public Health
VISITING PROFESSORSHIPS AND SPECIAL LECTURES
Invited Speaker. "Mechanism of Insulin Resistance in Uremia." University of Pennsylvania. Philadelphia, PA, 1981
Invited Speaker. "Insulin Binding and Processing in Isolated Rat Hepatocytes." University of Virginia. Charlooesville, VA, 1981
Invited Speaker. "Insulin Resistance in Uremia." University of South Florida. Tampa, FL, 1982
Invited Speaker. "Insulin Resistance in Uremia." Duke University School of Medicine. Durham, NC, 1982
Program Chairman. "The Diagnoses and Treatment of Type II Diabetes." American Diabetes AssociaUon and East Carolina University School of Medicine. Greenville, NC, 1984
Invited Speaker. "Management of Type II Diabetes." At the "First Congress in Washington, DC of the Interamerican College of Physicians and Surgeons." Washington, DC, 1984
Invited Speaker. "Mechanism of Insulin AcUon" and "Hyperlipidemia in Diabetes." The Third Annual ScienUfic Panel and the University of Zulia. Maracaibo, Venezuela, 1985
Invited Speaker. "Gastric Bypass: A Human Model to Study Diabetes." Duke University School of Medicine. Durham, NC, 1985
VisiUng Professor. "Mechanism of Insulin Resistance in the Human Liver from PaUents with NIDDM." University of Rochester School of Medicine and DenUstry. Rochester, NY, 1986
Moderator. "Learn by Sharing." PaUent EducaUon Program of the American Diabetes AssociaUon, North Carolina Affiliate. Raleigh, NC, 1985
Invited Speaker. "DiabeUc Emergencies" and "Office Management of Type II Diabetes." 14th Annual Beach Workshop. Myrtle Beach, SC, 1986
Invited Speaker. "Insulin Receptor Kinase AcUvity in Human Liver, Muscle, and Adipose Tissue." Lilly Research Laboratories. Indianapolis, IN, 1986
VisiUng Professor. "ECU Diabetes Program Project." Diabetes Branch of the NaUonal InsUtutes of Health, Bethesda, MD, 1986
VisiUng Professor. "Mechanism of Insulin Resistance in Type II Diabetes." Geriatric Research Center, Johns Hopkins University School of Medicine. BalUmore, MD, 1986
VisiUng Professor. "The Mechanism of Insulin Resistance in Type II Diabetes." Department of Pathology, University Complutense School of Medicine. Madrid, Spain, 1986
Invited Speaker. "The Human Endocrine System: A Brief Review." At the Fourth Annual Biotechnology Symposium." East Carolina University School of Medicine. Greenville, NC, 1986
VisiUng Professor. "Insulin Receptor Kinase in Important Target Tissues for Insulin in Type II Diabetes Mellitus." Department of Medicine, University of Rochester School of Medicine and DenUstry. Rochester, NY, 1987
Invited Speaker. "The Insulin Receptor and Liver, Skeletal Muscle, and Adipose Tissue from Humans with and without Type II Diabetes." Lilly Diabetes Care InternaUonal Symposium. Indianapolis, IN, 1987
Invited Speaker. "Mechanisms of Insulin Resistance in Type II Diabetes." At the "NaUonal InsUtutes of Health Centennial, Nurturing CreaUve Research Genius for Biomedicine." Duke University School of Medicine. Durham, NC, 1987
Symposium Chairman. "Diabetes Mellitus: Management in Pregnancy and Childhood." American Diabetes AssociaUon and East Carolina University School of Medicine. Greenville, NC, 1987
Invited Speaker. "Type II Diabetes Mellitus: Treatment and ComplicaUons." The XI Interamerican Medical Congress of the Spanish-‐American Medical Society. New York, NY, 1987
VisiUng Professor. "Mechanisms of Insulin Resistance in Type II Diabetes." University of Virginia Diabetes Center, Charlooesville, VA, 1987
VisiUng Professor. "Role of Insulin Receptor Tyrosine Kinase in Insulin Resistance." Glaxo Research Laboratory. Research Triangle Park, NC, 1987
Invited Speaker. "Advances in the Treatment of Type II Diabetes." At the XII Annual Conference of the North Carolina Academy of Physicians." Wrightsville, NC, 1988
Invited Speaker. "Carbohydrate Metabolism in Diabetes." At the "IX Annual Congress of the Spanish Society of Diabetes." Barcelona, Spain, 1988
Invited Speaker. "Current Views of EUology of Type II Diabetes: Are We Gewng There?" At "Diabetes Update 1988." American Diabetes AssociaUon and East Carolina University School of Medicine. Southern Pines, NC, 1988
Invited Speaker. "The Insulin Receptor in Obesity and NIDDM: A New Target for Clinical and Basic Research." At a symposium on the "Mechanism of Insulin Resistance in Type II Diabetes" 70th Annual MeeUng of the Endocrine Society. New Orleans, LA, 1988
VisiUng Professor and Clinical Scholar. Lilly task force on "Early RecogniUon and PrevenUon of Diabetes." Lilly Research Laboratories. Indianapolis, IN, 1988
Invited Speaker. "DiabeUc Emergencies." North Carolina Family Physician's Annual MeeUng. Wrightsville Beach, NC, 1988
Invited Speaker. "Diabetes." Geriatric Medicine Board Review. East Carolina University School of Medicine. Greenville, NC, 1988
VisiUng Professor. "Mechanism of Insulin Resistance in Type II Diabetes." Veterans AdministraUon Medical Center at Georgetown University. Washington, DC, 1988
Invited Speaker. "Insulin Receptor Kinase AlteraUons." At the "AcUon of Insulin and Related Growth Factors in Diabetes Mellitus." CelebraUng Joslin's 90th Anniversary. Joslin Diabetes Center and Harvard Medical School. Boston, MA, 1988
VisiUng Professor. "Mechanism of Insulin Resistance in Type II Diabetes." University of Illinois Chicago, IL, 1988
VisiUng Professor. "Insulin Resistance." University of California, San Diego, CA, 1988
Invited Speaker. "DevastaUon of the Disease: Type II Diabetes." Third Hispanic Medical Congress. Washington, DC, 1988
VisiUng Professor. "Mechanism of Insulin Resistance in Type II Diabetes" and "Chronic ComplicaUons of Diabetes." Diabetes Branch of the NaUonal InsUtutes of Health. Bethesda, MD, 1988
VisiUng Professor. "Mechanism of Insulin Resistance in Type II Diabetes" and "Chronic ComplicaUons of Diabetes." University of Colorado Health Sciences Center. Denver, Colorado, 1988
VisiUng Professor. "Mechanism of Insulin Resistance in Type II Diabetes." Diabetes Clinical Research InsUtute, Charlooesville, VA, 1989
VisiUng Professor. "The Insulin Receptor: A New Target For Basic and Clinical InvesUgaUons." Research Seminar, Emory University, Atlanta, GA, 1989
VisiUng Professor. "Mechanism of Insulin Resistance in Type II Diabetes." Diabetes Center of Eastern Virginia, Norfolk, VA, 1989
Invited Speaker. "Mechanism of Insulin AcUon." Inter-‐University Post-‐Graduate course on Molecular Mechanism of the Endocrine System, Fundacion Ramon Areces, Madrid, Spain, 1989
Keynote Speaker. "The Pathogenesis of Obesity" and "Meet the Professor: Problem Case Discussion." At Diabetes Mellitus -‐ Challenges in the 1990's." American Diabetes AssociaUon, Hilton Head Island, SC, 1989
Invited Speaker. "Clinical and Physiological Correlates of Glucose Transport in Obesity and Diabetes" at "The Symposium in FronUers in the Molecular and Cellular Biology and Glucose Transport." 49th Annual MeeUng and ScienUfic Sessions, American Diabetes AssociaUon, 1989
Invited Speaker. "Insulin Resistance in Obesity: Towards a Molecular Approach." UCLA Symposium on Molecular and Cellular Biology, Keystone, Colorado, 1989
Keynote Speaker. "Advances in Diabetes Mellitus" at the Mexican Society of NutriUon and Endocrinology, Monterey, Mexico, 1989
Keynote Speaker. "Obesity and Insulin Resistance" and "Meet the Professor: Diabetes Mellitus and Hypertension" at the IV InternaUonal Congress of Medicine, Victoria, Mexico, 1989
Invited Speaker. "Studies on the Mechanism of Insulin Resistance in Type II Diabetes." Merck, Sharp, & Dohme Co. Rahway, NJ, 1989
Invited Speaker. "The Insulin Receptor and Post Receptor in Liver in NIDDM: Effects of Sulfonylureas." Fourth InternaUonal Conference on Diabetes. University of Virginia, Charlooesville, VA, 1989
Keynote Speaker. "Cellular AlteraUons in Liver, Muscle, and Adipose Tissues Responsible for Insulin Resistance in Diabetes." MeeUng of the Diabetes Treatment Centers of American FoundaUon. 1989 Annual Physicians Conference. Palm Desert, CA, 1989
Invited Speaker. "Diabetes is a Serious Disease" 42nd Annual ScienUfic Assembly of the North Carolina Academy of Family Physicians. Greensboro, NC, 1990
Invited Speaker. "Cellular AlteraUons in Liver, Muscle, and Adipose Tissue Responsible for Insulin Resistance in NIDDM." Hershey Medical Center, Hershey, PA, 1990
Invited Speaker. "AlteraUons in Insulin Receptors and Glucose Transporters in Obese and DiabeUc Humans," at the Satellite MeeUng of the XI Amsterdam InternaUonal Congress of Pharmacology, "Pathophysiology and Treatment of Diabetes Mellitus" Montpellier, France, 1990
Invited Speaker. "Altered Coupling of the Insulin Receptor with Gi Protein in the Liver from PaUents with NIDDM" at the InternaUonal Symposium on Obesity and Diabetes Mellitus, Nagoya, Japan, 1990
Invited Speaker. "Insulin AcUon in Adipose Tissue and Muscle in Human Obesity and Diabetes" at the 6th InternaUonal Congress on Obesity, Kobe, Japan, 1990
Invited Speaker, "Diagnosis and Treatment of Diabetes Mellitus" and "Insulin Resistance in Obesity and Diabetes Mellitus" at the LII NaUonal Medical Congress, San Jose, Costa Rica, 1990
Invited Speaker, "Post-‐Receptor Defect in Type II Diabetes" American Diabetes AssociaUon, Minneapolis Affiliate, Minneapolis, MN, 1990
Invited Speaker, "G-‐Proteins in Diabetes" at the Mayo Clinic, Rochester, NY, 1990
Invited Speaker, "Overview of AlteraUons in Insulin AcUon in Human Diabetes" at the UCLA Symposium on Molecular and Cellular Biology, Park City, Utah, 1991
Invited Speaker, "Mechanism of Insulin Resistance in NIDDM." Miles Laboratories, West Haven, ConnecUcut, 1991
Invited Speaker, "Mechanisms and Management of Type II Diabetes." New Mexico Metabolism Symposium 1991. Taos, New Mexico, 1991
Invited Speaker, "Mechanism of Insulin Resistance in Type II Diabetes. "Baylor College of Medicine, Houston, Texas, 1991
Invited Speaker, "Diabetes Mellitus PrevenUon in the High Risk PaUent," at the "Current Advances in NutriUonal Medicine and Disease PrevenUon." Harvard Medical School, Boston, MA, 1991
Invited Speaker, "NIDDM: Insulin Resistance vs. Insulin SecreUon." NJ Affiliate of the ADA, Jamesburg, NJ, 1991
Keynote Speaker, "Diabetes in the 90's." American Diabetes AssociaUon, NC Affiliate, Raleigh, NC, 1991
Invited Speaker, "Insulin Resistance in NIDDM." University of Chicago, Chicago, IL, 1991
Invited Speaker, "Carbohydrate Metabolism in Obesity and Diabetes." NutriUon and Diabetes Mellitus: Focus for the 1990's. A Satellite Symposium of the 14th IDF Congress. BalUmore, MD, 1991
Invited Speaker, "Physiology of Insulin AcUon in Muscle." 14th InternaUonal Diabetes FederaUon Congress, Washington, DC, 1991
Invited Speaker, "Mechanism of Insulin AcUon." Satellite Symposium, 14th IDF Congress, Airily, VA, 1991
VisiUng Professor, "Cellular AlteraUons in Liver, Skeletal Muscle, and Adipose Tissue Responsible for Insulin Resistance in Obesity and Type II Diabetes." Symposium organized by the USSR Academy of Medical Sciences and the USSR Ministry of Health, Moscow, Russia, 1991
Invited Speaker, "The IGF-‐1 Receptor in NIDDM: A Pathway to Bypass Insulin Resistance?" 39th Annual Clinical Society ScienUfic MeeUng of the American Diabetes AssociaUon, New York Downstate Affiliate, New York City, 1991
Invited Speaker, "Mechanism of Insulin Resistance in Obesity." Workshop sponsored by the NaUonal Diabetes Advisory Board, NaUonal InsUtutes of Health, Arlington, VA, 1991
Invited Speaker, "Syndrome X." 11th Annual Day of Diabetes, American Diabetes AssociaUon, Columbus, Georgia, 1992
Invited Speaker, "Insulin Resistance in Obesity and Non-‐Insulin Dependent Diabetes: Cause or Effect." Western Metabolism Club, Carmel, California, 1992
VisiUng Professor, "Fat 1992", Grand Rounds, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, 1992
Invited Speaker, "Alteraciones a nivel de receptor y post receptor en la obesidad," XXV Congreso Nacional de la Sociedad Española de Ciencias Fisiológicas, Cordoba, Spain, 1992
Keynote Speaker, "Aspectos moleculares de la diabetes mellitus no insulinodependiente", VIII Congreso Asociación LaUnoamericana de Diabetes, Buenos Aires, ArgenUna, 1992
Simposium Speaker, "Resistencia insulinica: su rol en diversos síndromes," VII Congreso Asociación LaUnoamericana de Diabetes, Buenos Aires, ArgenUna, 1992
VisiUng Professor, "Weight Loss: Is it a Miracle?", Cooper Hospital/University of Medicine and DenUstry of New Jersey, Robert Wood Johnson Medical School, Camden, New Jersey, 1992
VisiUng Professor, "Insulin Resistance in Type II Diabetes", University of Piosburgh, Piosburgh, Pennsylvania, 1992
VisiUng Professor, "Pharmacological methods to bypass insulin resistance", Department of Biochemistry, University of Medicine and DenUstry of New Jersey/School of Osteopathic Medicine, Stralord, New Jersey, 1992
Invited Speaker, "Insulin Resistance in Type II Diabetes", InternaUonal Diabetes FederaUon Congress and the Dominican Republic AssociaUon of Endocrinology, Santo Domingo, Dominican Republic, 1993
VisiUng Professor, "Insulin Resistance", State University of New York Health Science Center at Brooklyn, Brooklyn, New York, 1993
VisiUng Professor, "Insulin Resistance: A target for the Clinical and Basic InvesUgator", The Milton S. Hershey Medical Center of the Pennsylvania State University, Hershey, Pennsylvania, 1993
Invited Speaker, "Beyond the Basics: Neuropathy", the 13th Annual Diabetes Update '93 -‐ American Diabetes AssociaUon, Philadelphia, Pennsylvania, 1993
Invited Speaker, "Obesity: A Disease of the Adipose Tissue", NaUonal InsUtutes of Health, Bethesda, Maryland, 1993
Invited Speaker, "The ABCs of Thyroid Disease", Eastern Shore Medical Symposium, Rehoboth Beach, Delaware, 1993
VisiUng Professor, "Gene Therapy for Insulin Resistance", Department of Biochemistry, School of Medicine, Universidad Complutense, Madrid, Spain, 1993
Keynote Speaker, "Diabetes in LaUnos" 8th Hispanic Medical Congress. The Interamerican College of Physicians and Surgeons, San Juan, Puerto Rico, 1993
Invited Speaker, "The TranslaUon of the DCCT to the Care of PaUents with Type II Diabetes Mellitus" The Opening Symposium of the Joslin Center for Diabetes at Jefferson Medical College and Wills Eye Hospital, Philadelphia, 1994
Invited Speaker, "Weight Loss in Severely Obese Subjects Prevents Type II Diabetes" InternaUonal Symposium sponsored by the Chinese NutriUon Society and Shanghai NutriUon Society. Beijing, China, 1994
Invited Speaker, "Thyroid Nodules" Diabetes-‐Endocrine Symposium, Medical College of Pennsylvania, Philadelphia, Pennsylvania, 1994
Leadership Workshop: "TherapeuUc Choices in NIDDM” 54th Annual MeeUng, American Diabetes AssociaUon, New Orleans, 1994
Invited Speaker, "Morbid Obesity and Diabetes" 7th InternaUonal Congress of Obesity Satellite Symposium on Surgical Treatment of Obesity, Montreal, Quebec, Canada, 1994
Keynote Speaker, "Insulin Resistance from the laboratory to the bedside", XVI Internal Medicine Chilean Congress, SanUago, Chile, 1994
Symposium Speaker, "Current and future treatment of Diabetes Mellitus", XVI Internal Medicine Chilean Congress, SanUago, Chile, 1994
Invited Speaker, "PrevenUon of diabetes: Is it possible? ", XVI Internal Medicine Chilean Congress, SanUago, Chile, 1994
Invited Speaker, "Insulin Analogs" American Diabetes AssociaUon, Northern Illinois Affiliate’s Thirty-‐Seventh Annual Professional Symposium, Chicago, 1994
Invited Speaker, "The TranslaUon of the DCCT to the Care of the PaUent with Type II Diabetes Mellitus", The Third Annual Controversies in Ambulatory Care Medicine, Philadelphia, 1994
VisiUng Professor, "PrevenUon of Type II Diabetes: The Challenge of the Next Decade", Medical Grand Rounds, UMDNJ-‐Robert Wood Johnson Medical School, New Brunswick, NJ, 1995
VisiUng Professor, “The PromoUon of the Adipocyte: from storage to an endocrine cell”, Grand Rounds, University of Southern California School of Medicine, Los Angeles, CA, 1995
VisiUng Professor, “¿Es el adiosito inteligente?”, Consejo Superior de InvesUgaciones Cien~ficas, Madrid, Spain, 1995
Leadership Workshop: "Insulin AcUon Enhancers”, 55th Annual MeeUng, American Diabetes AssociaUon, Atlanta, Georgia, 1995
Invited Speaker, “Impact of weight loss by surgery on metabolic fitness”, FASEB Summer Conference on GeneUc and Behavioral Influences on Nutrient Metabolism and Obesity, Copper Mountain, Colorado, 1995
VisiUng Professor, “Ob protein resistance in human obesity”, University of Chicago, Chicago, Illinois, 1995
Plenary Speaker, “Studies of LepUn in Human Subjects”, NAASO MeeUng, Baton Rouge, Louisiana, 1995
Symposium Speaker, “The Gut and NIDDM”, Precose Specialist InvesUgator MeeUng, Lincolnshire, IL, 1995
VisiUng Professor, “¿Terapia molecular de la diabetes o de la obesidad?”, V Congreso de Ciencias FarmacéuUcas, Madrid, Spain, 1995
Symposium Speaker, “Obesidad e insulino resistencia”, Sociedad Mexicana de Nutrición y Endocrinologia, Guanajuato, Mexico, 1995
Symposium Speaker, “LepUn: The sensor of either fact mass or energy balance?”, American Society for Parenteral and Enteral NutriUon, Washington, DC, 1996
Symposium Speaker, “Advances en Fisiopatologia de la Obesidad”, Canary Islands, Spain,1996
Invited Speaker, “The Ob Gene in Human Obesity”, Western Metabolism Club, Carmel, CA, 1996
Invited Speaker, “Ob Protein in Human Obesity”, IBC’s Second Annual InternaUonal Symposium, Washington, DC, 1996
Invited Speaker, “New Insights into the Pathophysiology and Therapy of Obesity: The LepUn Story”, Sixteenth MeeUng of the InternaUonal ScienUfic Commioee on Diabetes, Cologne, Germany, 1996
Invited Speaker, “Obesity: A GeneUc Disease?”, Fourth ScienUfic Course in PancreaUc Islet Physiology and Pathology, Barcelona, Spain, 1996
Invited Speaker, “Obesity: What Can be Done?”, Clinical Endocrinology, Harvard Medical School, Boston, MA, 1996
Invited Speaker, "Human Obesity: What Have We Learned from Recent GeneUc Insights?", Biomedicine '96, Washington, D.C., 1996
VisiUng Professor, "LepUn: The Tale of an Obesity Gene, Part II: Rx: LepUn Sc, qday and eat anything you want , East Carolina University, Greenville, NC, 1996
Invited speaker, "LepUn Physiology and Pathophysiology in Man", American Society for Clinical InvesUgaUon, Washington, D.C., 1996
Symposium Speaker, "Molecular therapy of obesity or diabetes? That is the quesUon", XIII MeeUng of the Spanish Diabetes Society, Oviedo, Spain, 1996
Keynote speaker, "LepUn: The tale of an obesity gene: American Diabetes AssociaUon, Amelia Island, Florida, 1996
Symposium Speaker: “Obesity and Diabetes” 4th Annual Congress on Women’s Health, Washington, D.C., 1996
Invited Speaker, “LepUn: The Tale of an Obesity Gene” Annual Research Symposium, The InsUtute of NutriUon, University of North Carolina, Chapel Hill, NC, 1996
Invited Speaker, “Ob Protein in Human Obesity” IBC’s Third InternaUonal Symposium -‐ Obesity -‐ Advances in Understanding and Treatment. San Diego, CA, 1996
Invited Speaker, “MeeUng the Needs of paUents: Emerging OpUons in Diabetes Care”. 34th Annual MeeUng of the European AssociaUon for the Study of Diabetes. Vienna, Austria, 1996
Invited Speaker. “Obesity as a Metabolic Disease”. 6th Annual Turamberry Conference. Aventura, Florida, 1996
Invited Speaker. “The ob Gene Product and Nutrient Balance”. North American AssociaUon for the Study of Obesity. Breckenridge, Colorado, 1996
Invited Speaker. XXVI Congreso de la Asociación Española de Pediatria. Valencia, Spain, 1996
Invited Speaker. Human Obesity: Beyond LepUn ProducUon. InternaUonal Congress on AnU-‐Obesity Drug Targets. Cambridge, MA., 1996
Invited Speaker. Insulina y lepUna: La Extraña Pareja. VIII Congreso Sociedad Valenciana de Endocrinologia, Diabetes y nutrición. Valencia, Spain, 1996
Invited Speaker. Chapter One in the Story of LepUn in Humans. American Society for Clinical Pharmacology and TherapeuUcs. San Diego, CA, 1997
Invited Speaker. “Pathophysiology of Obesity”. Symposium of the German Endocrine Society. Lübeck, Germany, 1997.
Invited Speaker. “LepUn: The Second Year”. 2nd World Conference of the InternaUonal Society for Molecular NutriUon and Therapy. Winnipeg, Canada, 1997.
Invited Speaker. "LepUn: From Rodents to Humans". InternaUonal Diabetes FederaUon Congress, Helsinki, Finland, 1997
Invited Speaker. “LepUn: The New Lean Gene”. European Congress of Clinical Chemistry “Medlab97”, Basel, Switzerland, 1997
Invited Speaker. Grand Rounds. "LepUn: From Rodents to Humans". Tulane University, New Orleans, Louisiana, 1997
Invited Speaker, Plenary Session. "Current and Future ImplicaUons For the Use of LepUn in the Treatment of Obesity". NAASO Annual MeeUng, Cancun, Mexico, 1997
Invited Speaker, Conferencia “Diabetes, obesity y lepUn”. Simposia Harvard -‐ Joslin -‐ SBD, XI Congreso Brasileño de Diabetes, Porto Alegre, Brazil 1997
Medical Grand Rounds -‐ “The Role of LepUn in Body Weight RegulaUon”. The University of Texas. San Antonio, TX, 1997
Research Seminar: “Strategies for the treatment of type II diabetes”. Garvan InsUtute. Sydney, Australia, 1997
Research Seminar: “Recent Advances on LepUn”. The Walter and Eliza Hall InsUtute for Medical Research. Melbourne, Australia, 1997
Plenary Lecturer: “Strategies for the treatment of Obesity”. NAASO and American Society of Clinical NutriUon. Merida, Mexico, 1997
Congreso Nacional de la Sociedad Española de Diabetes y Obesidad: “LepUna y obesidad". Caceres, Spain, 1997
Invited Speaker -‐ Bio-‐chemistry Seminar: “Strategy of drug discovery for the treatment of obesity”. Indiana University Medical Center. Indianapolis, IN, 1998
Invited Speaker: American Diabetes AssociaUon “LepUn Pathway as a Target for Treatment”. San Francisco, California, 1998
Invited Speaker: “Addressing the AcceleraUng Cost of Chronic Diseases: A Case Study”. MeeUng the 21st century healthcare challenge: A New Vision for PharmaceuUcal InnovaUon. PHRMA, U.S. Embassy. Tokyo, Japan, 1998
Opening Lecture of the XIV Sociedad Española de Diabetes: “En el camino a la cura de la Diabetes” Murcia, Spain, 1998
Keynote lecture: “A new endocrine cell: Biology and FuncUon of Adipocytes” 71st Annual MeeUng of the Japan Endocrine Society. Fukuoka, Japan, 1998
Plenary lecture: “LepUn: the Past, Present and Future”. 71st Annual MeeUng of the Japan Endocrine Society. Fukuoka, Japan, 1998
Plenary lecture: “From New Genes to New Treatments”. Satellite Symposium of the 8th InternaUonal Congress on Obesity. Paris, France, 1998
Plenary lecture: “Emerging Therapies for Type II Diabetes”. 34th Annual MeeUng of the European AssociaUon for the Study of Diabetes. Barcelona, Spain, 1998
Conferencia Magistral -‐ Hospital Maciel: “ LepUna la Voz Del Adiosito”. Simposio Obesidad y Diabetes Mellitus -‐ Cuando Y Como Intervenir. Montevideo, Uruguay, 1998
Conferencia Magistral -‐ Hospital Maciel: “Intervenciones Futuras en el Manejo de la Obesidad. Montevideo, Uruguay, 1998
Lilly Symposium -‐ Temas actuales en Diabetes. “LepUna y Obesidad”. Montevideo, Uruguay, 1998
Invited Speaker: “Opciones terapéuUcas en el síndrome de insulinorresistencia”. XI Congreso ArgenUno de Diabetes. Cordoba, ArgenUna, 1998
Invited Speaker: “LepUna y Obesidad”. XI Congreso ArgenUno de Diabetes. Cordoba, ArgenUna, 1998
Opening Lecture: “LepUna: La voz del Adiosito”. III Curso Sobre InvesUgaciones Biomedicas, Universidad de Granada y Consejo Superior de InvesUgaciones Cien~ficas. Granada, Spain, 1998
Symposium Speaker: “New Molecular Target for the treatment of Obesity”. “VI MeeUng on Lipid Metabolism and Related Pathology” InsUtuto Superior de Ciencias da Sande-‐Sul. Costa da Caprica, Portugal, 1998
Symposium Chairman and Speaker: “Neuroendocrine integraUon of appeUte". Experimental Biology ‘99 MeeUng. Washington, D.C. 1999
Invited Speaker: "LepUn: The tale of an obesity gene and it's applicaUon to children". Building Bright Futures: Neonatal, Pediatric and Adolescent NutriUon in the 21st Century. Indiana University School of Medicine, Indianapolis, IN. 1999
Symposium Co-‐Chairman and Speaker. "On the trail to cure obesity". GeneUcs, Pathophysiology and TherapeuUcs on the Eve of a Major Conceptual RevoluUon. Euro-‐Conference InsUtute Pasteur. Paris, France, 1999
Invited Speaker: "Insulin Resistance: A target for drug therapy at the CMES Ancillary Symposium, The Endocrine Society. Toronto, Canada, 2000
VisiUng Professor: “New targets for the treatment of obesity”. Medical Grand Rounds, University of Piosburgh School of Medicine. Piosburgh, PA. 2001
Invited Speaker: “The treatment of diabetes in the new Millennium. Italian Society of Diabetes. Florence, Italy, 2002
Symposium Speaker: “New Drug Therapies for Obesity” at Obesity: Molecular Causes and New Pathways for Treatment and PrevenUon. American AssociaUon for the Advancement of Science (AAAS) Annual MeeUng. Denver, Colorado. 2003
Keynote Speaker: “The Do’s and Do Not’s in Science: From Fuller Albright to the Present”. Graduate Student Research Day. East Carolina University. Greenville, NC. 2003
Symposium Speaker: “Obesity and the Metabolic Syndrome: IdenUfying Underlying Mechanisms and Emerging Therapies for Pharmacological Treatment”. PharmaceuUcal EducaUon Associates. Washington, DC. 2003.
Roundtable ParUcipant: “Obesity and Cancer” NaUonal Dialogue on Cancer. Sponsored by President George W. and Barbara Bush. Kennebunkport, Maine. 2003
Keynote Speaker and Chairperson: “OpportuniUes and Challenges of TherapeuUc Development for Obesity”. World Obesity Congress & Expo. Washington, DC. 2004
Symposium Speaker: “Addressing the Obesity Epidemic: From Bench to Bedside to Market”. The Endocrine Society’s 86th Annual MeeUng. New Orleans, LA. 2004
Invited Speaker: “Overcoming Diabetes: A Long March from Discovery to CommercializaUon”. The Opening Ceremony of the Peking University Diabetes Center. Beijing, China. 2004
Invited Speaker: “AnU-‐Obesity Drug Development: From Target IdenUficaUon to Launch”. NAASO 2004 ScienUfic MeeUng. Las Vegas, NV. 2004
Invited Speaker: “New Therapies for Diabetes”. Leerink Swann/MEDACorp. Inaugural Health Care Conference. New York, NY. 2005
Invited Speaker: “Insulin SensiUvity Enhancers for the Treatment and PrevenUon of Diabetes“ Diabetes and Obesity Research Day. East Carolina University, Brody School of Medicine. Greenville, NC. 2005
Keynote Speaker and Chairperson: “New OpportuniUes and Challenges of TherapeuUc Developments with Obesity and Weight Loss”. World Obesity Congress & Expo. Washington, DC. 2005
Keynote Speaker: “On the Trail to ARREST the Progression of Type 2 Diabetes” College of Agriculture and Life Sciences, University of Arizona. Phoenix, AZ. 2005 Keynote Speaker: “On the Trail to ARREST the Progression of the Metabolic Syndrome” 8th Symposium Fundacion Lilly “New Approaches to the Metabolic Syndrome” San Lorenzo de El Escorial, Madrid. 2005
Invited Speaker: “May be difficult at Umes…?” At The 5th NaUonal Metabolic Day. Utrecht University, Amsterdam, The Nederland 2006
Keynote Speaker: “Diabesity” 13th Annual Kaiser Permanente Diabetes Symposium. Woodland Hills, CA 2007 Invited Speaker and panel member: “Clinical Trials, Sewng the stage for the future”. At the inaugural Clinical Trial Regional Exchange Group, The North Carolina Biotechnology Center. Greenville NC, 2007
Post Graduate Course in Endocrinology: “Obesity”. At the Universidad Catolica, Montevideo, Uruguay, 2008
Invited Speaker: “Peers for Progress”. At the School of Medicine, Maciel Hospital. Montevideo, Uruguay, 2008
PUBLICATIONS
1. Caro, J.F., A. Besarab, J.R. Burke, and J.A. Glennon. Propranolol: A possible role in the treatment of renal osteodystrophy. Lancet II:451,1978.
2. Caro, J.F., and A. Besarab. Propranolol therapy for hyperparathyroidism. Lancet II:827,1978.
3. Caro, J.F., A.W. Meikle, J.H. Check, and S.N. Cohen. "Normal suppression" to dexamethasone in Cushing's disease: An expression of decreased metabolic clearance for dexamethasone. J. Clin. Endocrinol. Metab. 47:667,1978.
4. Ballas, S.K., J.F. Caro, and O. Miguel. Quinidine-‐induced hemolyUc anemia: Immunohematologic characterizaUon. Transfusion 18:215,1978.
5. Besarab, A., and J.F. Caro. Mechanism of hypercalcemia in malignancy. Cancer 6:2276,1978.
6. Caro, J.F., A. Besarab, and J.A. Glennon. SymptomaUc hypocalcemia following combined calcitonin and mithramycin therapy for hypercalcemia in malignancy. Cancer Treat Reports 62:1561,1978.
7. Check, J.H., J.F. Caro, L. Jackson, K. Nowroozn and A.F. Rakoff. Clinical mixed gonadal dysgenesis without Y chromosome. Am. J. Obstet. Gynecol. 131:346,1978.
8. Check, J.H., J.F. Caro, and J.T. Flynn. CysUc gynecomasUa in a male treated with clomiphene citrate. Infert. Sterility 30:713,1978.
9. Caro, J.F., A. Besarab, and J.T. Flynn. Prostaglandin E and hypercalcemia in breast carcinoma: Only a tumor marker? A need for prospecUve. Am. J. Med. 66:337,1979.
10. Caro, J.F., H.L. Israel, and J.A. Glennon. Galactorrhea in sarcoidosis: Dynamic studies of prolacUn, growth and gonadotropic hormone levels. Am. J. Med. Sci. 277:1,1979.
11. Check, J.H., J.F. Caro, B. Kendall, L.A. Peris, and B.L. Wellenback. Cushing's syndrome in pregnancy: Effect of associated diabetes on fetal and neonatal complicaUons. Am. J. Obstet. Gynecol. 44:846,1979.
12. Check, J.H., J.F. Caro, L. Criden, R. Meltz, and K. Brownstein. Leyding cell responsiveness with gonadal cell resistance to gonadotropin therapy in Kallman's syndrome. Am. J. Med. 67:495,1979.
13. Caro, J.F., J.H. Castro, and J.A. Glennon. Effect of long-‐term propranolol administraUon on parathyroid hormone and calcium concentraUon in primary hyperparathyroidism. Ann. Int. Med. 91:740,1979.
14. Caro, J.F., N.G. Sloane, and J.A. Glennon. Hyperthyroidism with normal serum T4, T3 and TBG immunoreacUvity. J. Clin. Pat. 33:868,1980.
15. Caro, J.F., and P.D. Woolf. Pituitary-‐ovarian axis responsiUvity to prolonged GnRH infusion in normal and hyperprolacUnemic women. J. Clin. Endo. Metab. 50:999,1980.
16. Insogna, K.L., D.R. Bordley, J.F. Caro, and D.H. Lockwood. Osteomalacia and weakness due to excessive antacid ingesUon. J.A.M.A. 244:2544,1980.
17. Castro, J.H., J.F. Caro, Kim, and J.A. Glennon. Effects of PTH infusion in primary hyperparathyroidism on plasma prolacUn in man. J. Clin. Endo. Metab. 51:397,1980.
18. Caro, J.F., and J.M. Amatruda. FuncUonal relaUonship between insulin binding, acUon and degradaUon. J. Biol. Chem. 255:10052,1980.
19. Caro, J.F., and J.M. Amatruda. Insulin receptors in hepatocytes: Post receptor events mediate down regulaUon. Science 210:1029,1980.
20. Caro, J.F., and J.M. Amatruda. The effects of fasUng on glucagon binding and acUon in isolated hepatocytes. Metabolism 29:732,1980.
21. Caro, J.F. and J.A. Glennon, and H.L. Israel. Neuroendocrine studies in sarcoidosis. William, J.W. and Davis, B. H. (Eds.), Alpha Omega Publ. pp.587,1980.
22. Cech, J.N., R.B. Freeman, J.F. Caro, and J.M. Amatruda. Insulin acUon and binding in isolated hepatocytes from fasted, streptozotocin diabeUc and older, spontaneously obese rats. Biochem. J. 188:839,1980.
23. Caro, J.F., and J.M. Amatruda. Evidence for the modulaUon of insulin acUon and degradaUon independently of insulin binding. Am. J. Physiol. 240:E325,1981.
24. Besarab, A., J.F. Caro, B.U. Ihle, J.F. Burke, and J.A. Glennon. Suppression of secondary hyperparathyroidism by propranolol in renal failure paUent. Nephron 27:127,1981.
25. Besarab, A. and J.F. Caro. Increased absolute calcium binding to albumin in hypoalbuminaemia. J. Clin. Path. 34:1368,1981.
26. Basal, S., P.D. Woolf, J.A. Fischer, and J.F. Caro. Dopamine does not affect parathyroid funcUon in man. J. Clin. Endo Metab. 54:651,1982.
27. Caro, J.F., and J.M. Amatruda. The regulaUon of lipid synthesis in freshly isolated hepatocytes and primary cultures of hepatocytes from fasted rats: The primary role of insulin. Metabolism 31:14,1982.
28. Caro, J.F., and J.M. Amatruda. GlucocorUcoid-‐induced insulin resistance: The importance of post receptor events in the regulaUon of insulin binding and degradaUon. J. Clin. Invest. 69:866,1982.
29. Caro, J.F., G. Muller and J.A. Glennon. Insulin processing by the liver. J. Biol. Chem. 257:8459,1982.
30. Kauffman, J.M., and J.F. Caro. Insulin resistance in uremia: CharacterizaUon of insulin acUon binding and processing in isolated hepatocytes from chronic uremic rat. J. Clin. Invest. 71:698,1983.
31. Caro, J.F., and S. Jacoby. Lipid synthesis in freshly isolated and primary culture of rat hepatocytes from chronic uremic rats. J. Clin. Invest. 72:882,1983.
32. Caro, J.F., F. Folli, F. Cecchin, and M.K. Sinha. Chemical mediator of insulin acUon sUmulates lipid synthesis and down regulates the insulin receptors in primary cultures of rat hepatocytes. Biochem. Biophys. Res. Commun. 115:375,1983.
33. Helineck, T.G., S. Sadel, and J.F. Caro. The effect of chronic uremia on glucagon binding and acUon in isolated rat hepatocytes. Metabolism 33:158,1984.
34. Caro, J.F., F. Cecchin, and M.K. Sinha. Is glycosylaUon in the liver needed for insulin binding, processing, and acUon: evidence for heterogeneity. J. Biol. Chem. 259:12810,1984.
35. Sinha, M.K., and J.F. Caro. Presence of an acUvator of pyruvate dehydrogenase in human circulaUon: elevaUon following a glucose load and possible relaUon to an insulin mediator. Biochem. Biophys. Res. Commun. 129:41,1985.
36. Chaplinski, T.J., T.E. Benneo, and J.F. Caro. AlteraUon in insulin receptor expression accompanying differenUaUon of HL-‐60 leukemia cells. Cancer Research 46:1203,1986.
37. Caro, J.F., O. Iooop, W.J. Pories, D. Meelheim, E.G. Flickinger, F. Thomas, M. Jenquin, J.F. Silverman, P.G. Khazanie, and M.K. Sinha. Studies on the mechanism of insulin resistance in the liver from humans with non-‐insulin-‐dependent diabetes; insulin acUon and binding in isolated hepatocytes, insulin receptor structure and kinase acUvity. J. Clin. Invest. 78:249,1986.
38. Folli, F., M.K. Sinha, D. Brancaccio, and J.F. Caro. Insulin resistance in uremia: In vitro model in the rat liver using human serum to study mechanism(s). Metabolism 35:989,1986.
39. Dohm, G.L, J.F. Caro, and T. Fushiki. Mechanisms(s) responsible for increased glucose uptake during exercise. I.R.C.S. Med Sci 14:1174,1986.
40. Dohm, G.L., M.K. Sinha, J.F. Caro. Insulin receptor binding and protein kinase acUvity in muscles of trained rats. Am. J. Physiol. 252:E170,1987.
41. Caro, J.F. Non-‐Insulin-‐Dependent Diabetes Mellitus in Hispanic Americans, A Roundtable Discussion, Upjohn, PublicaUon No. 8319,1987.
42. Sinha, M.K., W.J. Pories, E.G. Flickinger, D. Meelheim, and J.F. Caro. Insulin receptor kinase acUvity of adipose Ussue from morbidly obese humans with or without noninsulin-‐dependent diabetes. Diabetes 36:620,1987.
43. Caro, J.F., W.J. Pories, E.G. Flickinger, D. Meelheim, O. Iooop, M. Jenquin, M.K. Sinha, and G.L. Dohm. Insulin receptor kinase in human skeletal muscle from obese subjects with and without non-‐insulin dependent diabetes. J. Clin. Invest. 79:1330,1987.
44. Forsayeth, J.R., J.F. Caro, M.K. Sinha, B.A. Maddux, and I.D. Goldfine. Monoclonal anUbodies to the human insulin receptor that acUvate glucose transport but not insulin receptor kinase acUvity. Proc. Nat. Acad. Sci (USA) 84:3448,1987.
45. Caro, J.F., M.K. Sinha, and G.L. Dohm. Effect of chronic uremia on fructose 2,6-‐bisphosphate glycolyUc and gluconeogenic enzymes in rat liver. Biochem. Biophys. Res. Commun. 144:352,1987.
46. Pories W.J., J.F. Caro, E.G. Flickinger, H.D. Meelheim, and M.S. Swanson. The control of diabetes mellitus (NIDDM) in the morbidly obese with the Greenville Gastric Bypass. Annals of Surgery 206:316,1987.
47. Sinha, M.K., L.G. Taylor, W.J. Pories, E.G. Flickinger, D. Meelheim, S. Atkinson, N.S. Sehgal, and J.F. Caro. Long-‐term effect of insulin on glucose transport and insulin binding in cultured adipocytes from normal and obese humans with and without non-‐insulin dependent diabetes. J. Clin. Invest 80:1073,1987.
48. Caro, J.F., J.A. Shafer, S.I. Taylor, S.M. Raju, N. Perrow, and M.K. Sinha. Insulin sUmulated protein phosphorylaUon in human plasma liver membranes: detecUon of endogenous or plasma membrane associated substrates. Biochem. Biophys. Res. Commun. 149:1008,1987.
49. Dohm, G.L., E.B. Tapscoo, W.J. Pories, D.J. Dabbs, E.G. Flickinger, D. Meelheim, T. Fushiki, S.M. Atkinson, and J. F. Caro. An in vitro human muscle preparaUon suitable for metabolic studies. Decreased glucose transport in muscle from morbidly obese subjects. J. Clin. Invest. 82:486,1988.
50. Caro, J.F., J. Poulos, O. Iooop, W.J. Pories, E.G. Flickinger and M.K. Sinha. Insulin-‐like growth factor I binding in hepatocytes from human liver, human hepatoma, and regeneraUng and fetal rat liver. J. Clin. Invest. 81:976,1988.
51. Cecchin, F., O. Iooop, M.K. Sinha and J. F. Caro. Insulin resistance in uremia: Insulin receptor kinase acUvity in liver and muscle from chronic uremic rats. Am. J. Physiol. 254:E394,1988.
52. Caro, J.F., F. Cecchin, F. Folli, C. Marchini, and M.K. Sinha. Effects of T3 on insulin acUon, insulin binding and insulin receptor kinase acUvity in primary cultures or rat hepatocytes. Horm. Metab. Res 20:327,1988.
53. Misbin, R.I., A. Green, I.M. Alverz, E.C. Almira, G.L. Dohm, and J.F. Caro. InhibiUon of insulin sUmulated glucose transport by a factor extracted from the serum of a paUent with insulin resistance. Diabetes 37:1217,1988.
54. Caro, J.F., S.M. Raju, M.K. Sinha, I.D. Goldfine, and G.L. Dohm. Heterogeneity of 5human liver, muscle, and adipose Ussue insulin receptor. Biochem. Biophys. Res. Commun. 151:123,1988.
55. Goldfine, I.D. and J.F. Caro. Molecular and Cellular Biology of the Insulin Receptor in Diabetes Mellitus. In: Molecular and Cellular Biology of Diabetes Mellitus, Vol II. B Draznin, S. Melmed and D. LeRoith, (Eds.) Alan R. Liss, Inc., New York, pp.11,1989.
56. Silverman, JF., W. J. Pories, J.F. Caro. Liver Pathology in Diabetes Mellitus and Morbid Obesity: Clinical, Pathologic, and Biochemical ConsideraUons. S. Sommers, P.P. Rosen, and R.E. Fechner (Eds). Appleton & Lange. Pathology Annual 24:275,1989.
57. Caro, JF., G.L.Dohm, W.J. Pories, and M.K. Sinha. Cellular AlteraUons in Liver, Skeletal, Muscle, and Adipose Tissue Responsible for Insulin Resistance in Obesity and Type II Diabetes. Diabetes Metabolism Review 5:665,1989.
58. Contreras, N.I. and J.F. Caro. The Collisional Hypothesis of Insulin AcUon, Receptor InternalizaUon and Diabetes. TIBS 14:399,1989.
59. Thakkar, J.K., R. DiMarchi, K. MacDonald and J.F. Caro. Effect of insulin and insulin-‐like growth factors I and II on phosphaUdylinositol and phosphaUdylinositol-‐4.5-‐biophosphate breakdown in liver plasma membranes from humans with and without type II diabetes. J. Biol. Chem. 264:7169,1989.
60. Caro, J.F., O. Iooop, and M.K. Sinha. Glyburide but not ciglitazone enhances insulin acUon in the liver independent of insulin receptor kinase acUvaUon. Metabolism 38:606,1989.
61. Sinha, M.K., C. Buchanan, N. Leggeo, L. MarUn, P.G. Khazanie, R. DiMarchi, W.J. Pories, and J.F. Caro. Mechanism of IGF-‐I sUmulated glucose transport in human adipocytes: demonstraUon of specific IGF-‐I receptors not involved in sUmulaUon of glucose transport. Diabetes 38:1217,1989.
62. Caro, J.F., G.L. Dohm, and M.K. Sinha. Insulin Resistance in Obesity. Adv. Diabetologia 2:1,1989.
63. Moller, D.E., A. Yokota, J.F. Caro, and J.S. Flier. Tissue-‐specific expression of two alternaUvely spliced insulin receptor mRNAs in man. Molecular Endocrinology 3:1263,1989.
64. Caro, J.F., M.K. Sinha, and G.L.Dohm. Insulin Resistance in Obesity. In: Obesity Towards a Molecular Approach. Alan R. Liss, Inc., New York. Vol. 132:203,1990.
65. Marcuard, S.P., B. Dunham, A. Hobbs, and J.F. Caro. Availability of insulin from total parenteral nutriUon (TPN) soluUons. J. Parent Enter Nutri. 14:262,1990.
66. Caro, J.F. "Mechanisms de accion de la insulina y resistencia a la insulina en la obsidad y diabetes Upo 2." In: Los islotes de Langerhans: un organo mulUendocrino. (Enrique Blazquez y Jorge Tamarit, eds.), Fundacion Romon Areces, pp.203,1990.
67. Thakkar, J.K., M.S. Raju, and J.F. Caro. 3H Myoinositol incorporaUon into phospholipids in liver microsomes from humans with and without Type II diabetes: The lack of synthesis of glycosyl-‐phosphaUdyl inositol, precursor of the insulin mediator inositol phosphate glycan. J. Biol Chem. 265,10:5475,1990.
68. Dohm, G.L., W. Elton, S.M. Raju, N. Mooney, R. DiMarchi, W.J. Pories, E.G. Flickinger, S.M. Atkinson, and J.F. Caro. IGF-‐I sUmulated glucose transport in human skeletal muscle and IGF-‐I resistance in obesity and NIDDM. Diabetes 39:1028,1990.
69. Contreras, I., G.L. Dohm, S. Abdallah, A. Wells, N. Mooney, A. Rovira, and J.F. Caro. The effect of fasUng on in vivo acUvaUon of the insulin receptor tyrosine kinase. Biochem. J. 265:887,1990.
70. Burguera, B., H. Werner, M. Sklar, Z Shen-‐Orr, B. Stannard, C.T. Roberts, Jr., S.P. Nissley, S.J. Vore, J.F. Caro, and D. LeRoith. Liver regeneraUon is associated with increased expression of the insulin-‐like growth factor II/mannose-‐6-‐phosphate receptor. Molecular Endocrinology 4:1539,1990.
71. Sinha, M.K. and J.F. Caro. Effect of insulin and tunicamycin on insulin receptor kinase acUvity in primary cultures of rat hepatocytes. Endocrinologia 37:18,1990.
72. Silverman, J.F., K. O'Brien, S. Long, N. Leggeo-‐Frazier, P.G. Khazanie, W.J. Pories, H.T. Norris, and J.F. Caro. Liver pathology in morbidly obese paUents with and without diabetes. Am. J. Gastroenter. 85:1349,1990.
73. Sinha, M.K., C. Buchanan, C. Raineri-‐Maldonado, P. Khazanie, S. Atkinson, R. DiMarchi, and J.F. Caro. IGF-‐II receptors and IGF-‐II sUmulated glucose transport in human fat cells. Am. J. Phys. 258:E534,1990.
74. Poulus, J.F., E.L. Treadwell, K. O'Brien, S. Long, and J.F. Caro. The presence of autoanUbodies to the IGF-‐I, IGF-‐II and insulin receptor in paUents with Type II (noninsulin-‐dependent) diabetes, impaired glucose tolerance and autoimmune diseases. Adv. Diabetologia 3:83,1990.
75. Caro, J.F. Effects of glyburide on carbohydrate metabolism and insulin acUon in the liver. Am J. Med. 89:17,1990.
76. Chen, J.J., H.Y. Lee, and J.F. Caro.ContribuUon of non-‐insulin-‐dependent diabetes mellitus to the insulin metabolic clearance rate of morbidly obese paUents. Clin. Med. J. (Taipei) 45:285,1990.
77. Burguera, B. and J.F. Caro. Mechanism of acUon of insulin: first chapter. Endocrinologia 37:1,1990.
78. Barakat, H.A., V.D. McLendon, J.W. Carpenter, R.H.L. Marks, N. Leggeo, K. O'Brien, and J.F. Caro. Lipogenic potenUal of liver from morbidly obese paUents with and without noninsulin-‐dependent diabetes. Metabolism 40:280,1991.
79. Chen J.J., N. Leggeo, K.O'Brien, S. Long, P.G. Khazanie, G.L. Dohm, M.K. Sinha, H.A. Barakat, W.J. Pories and J.F. Caro. "Insulin acUon in obesity and diabetes." In: Progress in Obesity Research. John Libbey and Company Ltd.,London, England, Chapter 57, pp.365,1991.
80. Caro, J.F., S.R. Madhu, J.C. Hale, N. Leggeo-‐Frazier, S. Long, W.J. Pories. Altered coupling of the insulin receptor with G1 protein in the liver from paUents with NIDDM. New DirecUons in Research and Clinical Works for Obesity and Diabetes Mellitus In: Excerpta Medica InternaUonal Congress Series, Elsevier Science Publishers, pp.53,1991.
81. Sinha, M.K., C. Raineri-‐Maldonado, C. Buchanan, W.J. Pories, C.C. Su, P.F. Pilch, and J.F. Caro. Adipose Ussue glucose transporters in non-‐insulin-‐dependent diabetes mellitus: decreased levels of muscle/fat and erythroid isoforms. Diabetes 40:472,1991.
82. Caro, J.F., J. Hodges, and M.K. Sinha. Increased insulin responsiveness in hepatocytes incubated with free faoy acid-‐poor albumin. Horm. Metab. Res. 23:362,1991.
83. Friedman, J.E., R.W. Dudek, D.S. Whitehead, D.L. Downes, W.R. Frisell, J.F. Caro, and G.L. Dohm. ImmunolocalizaUon of glucose transporter Glut4 with human skeletal muscle. Diabetes 40:150,1991.
84. Dohm, G.L., C.W. Elton, J.E. Friedman, P.F. Pilch, W.J. Pories, S.M. Atkinson, Jr., and J.F. Caro. Decreased expression of glucose transporter in muscle from insulin resistant paUents. Am. J. Physiol. 260:E459,1991.
85. Friedman, J.E., G.L. Dohm, C.W. Elton, A. Rovira, J.J. Chen, N.L. Frazier, S.M. Atkinson Jr., S.D. Long, and J.F. Caro. Muscle insulin resistance in uremic humans: Glucose transport, glucose transporters, and insulin receptors. Am. J. Physiol. 261:E87,1991.
86. Caro, J.F. Insulin resistance in obese and non-‐obese man. J. Clin. Endo Metab. 73:691,1991.
87. Burguera, B. and Caro, J.F. AlteraUons in insulin receptors and glucose transporters in obesity and Type 2 diabetes. In: FronUers in Diabetes Research. Lessons from Animal Diabetes III. Eleazar Shafrir (Ed.), Smith-‐Gordon and Company, Ltd. pg. 269,1991.
88. Burguera B., Long S., Frank H.B., DiMarchi R., Caro, J.F. Binding of insulin-‐like growth factors, proinsulin and proinsulin analogs to human liver, muscle and adipose Ussue receptors. J. Clin. Endocrinol. Metab. 72:1238,1991.
89. Burguera B, Madigan T., Mustafa, S.J., Frank, H.B., DiMarchi, R. and Caro J.F. The interacUon of proinsulin with insulin-‐like growth factors I and II receptors in smooth muscle membranes from bovine coronary arteria. Av Diabetol 5:187,1992.
90. Freidman, J.E., G.L. Dohm, N. Leggeo-‐Frazier, C.W. Elton, E.B. Tapscoo, W.P. Pories, and J.F. Caro. RestoraUon of insulin responsiveness in skeletal muscle of morbidly obese paUents aser weight loss: Effect on muscle glucose transport and glucose transporter GLUT-‐4. J. Clin. Invest. 89:701,1992.
91. Burguera, B., H. Werner, M.Couce, D. LeRoith, J.F. Caro. RegulaUon of IGF's receptor. RegulaUon of growth hormone and somaUc growth. LF de la Cruz (Ed.) Elsevier Amsterdam. pp.271,1992.
92. Caro, J.F. Mecanismos de la Accion de la insulina y resistencia a la insulina en la obesidad y diabetes Upo II. J LaUno Amer. Soc. Diab. 14:10,1992.
93. Pories, W.J., K.G. MacDonald, E.J. Morgan, M.K. Sinha, G.L. Dohm, M.S. Swanson, H.A. Barakat, P.G. Khazanie, N. Leggeo-‐Frazier, S. D. Long, K.F. O'Brien, and J.F. Caro. Surgical treatment of obesity and its effect on diabetes: 10-‐y follow-‐up. Am. J. Clin. Nutr. 55:582S,1992.
94. Caro, J.F., M. Jenquin, S. Long. Effects of phorbol esters on insulin receptor funcUon and insulin acUon in hepatocytes: evidence for heterogeneity. Mol. Cell Biochem. 109:115,1992.
95. Contreras, I., J.F. Caro, L. Aveledo, K. Diaz, P. Durrego, and J.R. Weisinger. In Chronic uremia, insulin acUvates receptor kinase but not pyruvate dehydrogenase. Nephron. 61:71,1992.
96. Pories, W.J., K.G. MacDonald, E.G. Flickinger, G.L. Dohm, M.K. Sinha, H.A. Barakat, H.J. May, P. Khazanie, M.S. Swanson, E. Morgan, N. Leggeo-‐Frazier, S.D. Long, B.M. Brown, K. O'Brien, and J.F. Caro. Is type II diabetes mellitus (NIDDM) a surgical disease? Ann. Surg. 251:633,1992.
97. Usala, A.L., Madigan, T., Burguera, B., Sinha, M.L., Caro, J.F., Powell, J.G., and Butler, P.C. Brief Report: Treatment of insulin resistance diabeUc ketoacidosis with insulin-‐like growth factor I in an adolescent with insulin-‐dependent diabetes. New England Journal of Medicine. 327:853,1992.
98. Caro, J.F. Diabetes and Hypertension: Not the Final Chapter. Diabetes Care. 16:540,1992.
99. Barakat, H.A., N. Mooney, K. O'Brien, S. Long, P. Khazanie, W.J. Pories, and J.F. Caro. Coronary artery disease risk factor in morbidly obese women with normal glucose tolerance. Diabetes Care. 16:144,1992.
100. Considine, R.V. and Caro, J.F. Protein Kinase C: Mediator or Inhibitor of Insulin AcUon? J Cell Biochem. 52:1,1992.
101. Serrano, J., C.M. Mateo and J.F. Caro. Insulin resistance: Cellular and molecular mechanisms. In: Recent Advances in Endocrinolgoy and Metabolism. Vol. 4. C.R.W. Edwards and D.W. Lincoln (Eds.), Churchill Livingstone, London, UK. Chapter 11.pp.167,1992.
102. Burguera, B., Couce, M.E., Caro, J.F. Fisiologia del receptor insulin-‐like growth factor-‐II/manosa 6 fosfato (IGF-‐II/Man 6-‐P R). In: Advances en Endocrinologia Celular Y Molecular. F.F. Casanueva, C. Dieguez, (Eds.), Fundacion Ramon Areces. pp.221,1992.
103. Burguera, B., H. Werner, M. Couce, C.T. Roberts, D. LeRoith, J.F. Caro. Physiology of the Insulin-‐Like Growth Factor I and Insulin-‐Like Growth Factor II/Mannose 6-‐Phosphate Receptors. LF de la Cruz (Ed.) Elsevier Amsterdam. pp.271,1992.
104. Burguera, B., Parzianella, N.A., Caro, J.F. Estudio de la expresion del transportador de glucosa GLUT-‐2 en el higado de pacientes diabéUcos. In Fronteras Endocrinologia. C. Dieguez, F.F. Casanueva (Eds.) Diaz Santos, Madrid, pp.19,1992.
105. Sinha, M.K., C. Buchanan, C. Raineri-‐Maldonado, I.D. Goldfine and J.F.Caro. RegulaUon of glucose transport by insulin and monoclonal insulin receptor anUbodies in adipocytes of paUents with NIDDM. Adv Diabetologia 5:90,1992.
106. Ravindra, R, J.F. Caro. Insulin sUmulates GDP release from G proteins in the rat and human liver plasma. J Cell Biochem 53:181,1993.
107. Arky, R.A., Caro, J.F., Johnson, C., Knowler, W.C., McManus, K., Moore, M.A., Sheps, S.G., Simonson, D.C. and Sprao, I. Consensus Development Conference on the Treatment of Hypertension in Diabetes. Diabetes Care. 16:1394,1993.
108. Kolaczynski, J.W. and Caro, J.F. Insulin-‐like Growth Factor-‐1 Therapy in Diabetes: Physiological Basis, Clinical Benefits and Risks. Ann Int Med 129:47,1994.
109. Kolaczynski, J.W. and Caro, J.F. Insulin-‐like Growth Factor-‐1 Therapy for Diabetes Mellitus? Diabetes Care. 17:92,1994.
110. Caro, J.F. Insulin-‐Dependent Diabetes Mellitus in Adults. In: Current Therapy in Endocrinology and Metabolism, 5th EdiUon. Bardin (Ed.) Mosby-‐Year Book, Inc. pp.384,1994.
111. Burguera, B., Dudek, R.W., Caro, M., Slieker, L.J., Heath, W.F., Busby, J. and Caro J.F. UpregulaUon of GLUT-‐2 protein levels in rat liver by chronic glucose administraUon. Adv Diabetologia 7:23,1994.
112. Kolaczynski, J.W., Morales, L.M., Moore, J.H., Considine, R.V., Pietrzkowski, Z., Noto, P.F. and Caro. J.F. A new technique for biopsy of human abdominal fat under local anesthesia with lidocaine. Acute and long term effects of lidocaine on human adipocytes in vitro revised. Int. J. Obesity 18:161,1994.
113. Caro, J.F., M.S. Raju, M. Caro, C.J. Lynch, J.H. Exton, J.K. Thakkar, L. Roy, J.C. Hale, and W.J. Pories. Guanine nucleoUde binding regulatory proteins in liver from humans with type II diabetes: evidence for altered "cross-‐talk" between the insulin receptor and Gi-‐proteins. J Cell Biochem 54:309,1994.
114. Long, S.D., O'Brien, K, McDonald, K.G., Frazier, N.L., Swanson, M.S., Pories, W.J., Caro, J.F. Weight loss prevents the progression of impaired glucose tolerance to type II diabetes: A longitudinal intervenUonal study. Diabetes Care 17:372,1994.
115. Poulos, J.E., N. Leggeo-‐Frazier, P. Khazanie, S. Long, R. Sportsman, K. MacDonald, and J.F. Caro. CirculaUng insulin-‐like growth factor concentraUons in morbidly obese paUents with NIDDM in response to the gastric bypass procedure. Horm. Met. Res. 26: 478,1994.
116. Friedman, J.E., J.F. Caro, W.J. Pories, J.L. Azevedo, and G.L. Dohm. Glucose Metabolism in Incubated Human Muscle: effect of obesity and non-‐insulin dependent diabetes mellitus. Metabolism 8: 1042,1994.
117. Burguera, B., C.W. Elton, J.F. Caro, E.B. Tapscoo, W.J. Pories, R. DiMarchi, K. Sakano and G.L. Dohm. SUmulaUon of glucose uptake by insulin-‐like growth factor II in human muscle is not mediated by the insulin-‐like growth factor II/mannose 6-‐phosphate receptor. Biochem J 300:781,1994.
118. Caro, J.F. and Rastogi, R.: Diabetes. In: Talking Health with Dr. Brian McDonough. B.P. McDonough (Ed.), Temple University Press, Philadelphia. Chapter 5, pp.71,1994.
119. Kennedy, J. and J.F. Caro. Sex hormones and singers: endocrine effects on voice. J NaUonal Assoc Teachers of Singing. November/December,1994.
120. Caro, J.F., S. Triester, V.K. Patel, E.B. Tapscoo, N.L.Frazier and G. L. Dohm. Liver glucokinase: Decreased acUvity in paUents with type II diabetes. Horm Met Res. 27:18,1995.
121. Poulos, J.E., T. Madigan, J. Serrano, J. Busby and J.F. Caro. The effects of GTPγS on insulin binding to human liver plasma membranes. Horm Met Res. 27:253,1995.
122. Considine, R.V., M.R. Nyce, L.E. Allen, L.M. Morales, S. Triester, J. Colberg, S.L. Jacoby and J.F. Caro. Protein Kinase C is Increased in the Liver of Humans and Rats with Non-‐Insulin-‐Dependent Diabetes Mellitus: An AlteraUon not due to Hyperglycemia. J Clin Invest. 95:2938,1995.
123. Considine, R.V., E.L. Considine, C.J. Williams, M.R. Nyce, S.A. Magosin, T.L. Bauer, E.L. Rosato, J. Colberg and J.F. Caro. Evidence Against Either a Premature Stop Codon or the Absence of Ob Gene mRNA in Human Obesity. J Clin Invest. 95:2986,1995.
124. Burguera, B., R.D. Dudek, and J.F. Caro. Liver GLUT-‐2 protein is not Upregulated in Non-‐Insulin Dependent Diabetes. Horm. Met. Res. 27:341,1995.
125. Hotamisligil, G.S., P. Arner, J.F. Caro, R.L. Atkinson and B.M. Spiegelman. Increased adipose Ussue expression on TNF-‐α in human obesity and insulin resistance. J. Clin. Invest. 95: 2409,1995.
126. Moore, J.H., J.W. Kolaczynski, L.M. Morales, R.V. Considine, Z. Pietrzkowski., P.F. Noto and J.F. Caro. Viability of Fat Obtained by Syringe SucUon Lipectomy: Effects of Local Anesthesia with Lidocaine. Aesth Plast Surg. 19:335,1995.
127. Caro, J.F. Weight loss in severely obese subjects prevents type II diabetes and reveres insulin resistance and early type II diabetes. Asia Pac. J. of Clin. Nut. 4:326,1995.
128. Caro, J.F. Biochemical Defects of Insulin AcUon in Humans. In: Diabetes Mellitus: A Fundamental and Clinical Text.. Chapter 57. Mosby-‐Year Book, Inc.,1995.
129. Fair-‐Covely, R.M., and J.F. Caro. Diabetes Mellitus. In: Current Diagnosis, 9th Ed.,1995.
130. Sinha, M.K., J.P. Ohannesian, M.L. Heiman, A. Kriaciunas, T.W. Stephens and J.F. Caro. Nocturnal rise of lepUn in lean, obese and non-‐insulin dependent diabetes mellitus subjects. J. Clin. Invest. 97:1344,1995.
131. Considine, R.V., M.K. Sinha, M.L. Heiman, A. Kriaciunas, T.W. Stephens, M.R. Nyce, J.P. Ohannesian, C.C. Marco, L.J. McKee,. T.L. Bauer and J.F. Caro. Serum ImmunoreacUve-‐LepUn concentraUons in normal weight and obese humans. New Engl J Med. 334:292,1996.
132. Considine, R.V., M.R. Nyce, L.M. Morales, S.A. Magosin, M. Sinha, T.L. Bauer, E.L. Rosato, J. Colberg, and J.F. Caro. Paracrine SUmulaUon of Preadipocyte Enriched Cultures ProliferaUon by Mature Adipocytes. Am J Physiol. 270:E895,1996.
133. Laine, C., and J.F. Caro. PrevenUng ComplicaUons in Diabetes Mellitus: The Role of the Primary Care Physician. Medical Clinics of North America. 80:457,1996.
134. Kennedy, J.W., and J.F. Caro. The ABC’s of Hyperthyroidism in the older paUent. Geriatrics. 51:22,1996.
135. Kolaczynski, J., and J.F. Caro. Molecular Mechanism of Insulin Resistance in Human Obesity. Curr Opin. in Endocrinol. and Diabetes. 3:36,1996.
136. Lynn, R.B., G.Y Cao, R.V. Considine, T.M. Hyde and J.F. Caro. Autoradiographic localizaUon of lepUn binding in the choroid plexus of ob/ob and db/db mice. Biochem. Biophys. Res. Comm. 219:884,1996.
137. Hassink, S.G., E. DeLancey, D.V. Sheslow, J.F. Caro, R.V. Considine, J.W. Kolaczynski and A. Spitzer. Serum lepUn levels correlate with all indirect measure of adiposity in obese children. Pediatrics. 98:201,1996.
138. Kolaczynski, J.W., M.R. Nyce, R.V. Considine, G. Boden, J.J. Nolan, R. Henry, S.R. Mudaliar, J. Olefsky and JF. Caro. Acute and Chronic Effect of Insulin on LepUn ProducUon in Humans: Studies in vivo and in vitro. Diabetes. 45:699,1996.
139. Considine, R.V., E.L. Considine, C.J. Williams, M.R. Nyce, P.L. Zhang, I. Opentanova, J.P. Ohannesian, J.W. Kolaczynski, T.L. Bauer, J.H. Moore and J.F. Caro. MutaUon screening and idenUficaUon of a sequence variaUon in the human Ob gene coding. Biochem. Biophys. Res. Comm. 220:735,1996.
140. Hotamisligil, G.S., P. Arner, J.F. Caro, R.L. Atkinson and B.M. Spiegelman. DifferenUal regulaUon of adipose Ussue TNF receptors in human obesity and insulin resistance. Diabetes. 46:451,1996.
141. Kolaczynski, J.W., R.V. Considine, J. Ohannesian, C. Marco, I. Opentanova, M.R. Nyce, M. Myint and J.F. Caro. Responses of lepUn to short-‐term fasUng and refeeding in humans: A link with ketogenesis but not ketones themselves. Diabetes 45:1511,1996.
142. Considine, R.V., E.L. Considine, C.J. Williams, T.M. Hyde and J.F. Caro. The Hypothalamic LepUn Receptor in Humans: IdenUficaUon of Incidental Sequence Polymorphisms and Absence of the db/db Mouse and fa/fa Rat MutaUons. Diabetes 19:992,1996.
143. Laine, C. and J.F. Caro. 1996. SubdiagnosUco y deficiencia en el tratamiento de diabetes Upo 2. MEDICO Interamericano 15:196,1996.
144. Sinha, M.K., I. Opentanova, J. P. Ohannesian, M.L. Heiman, J. Hale, G.W. Becker, R.R. Bowsher, T.W. Stephens and J.F. Caro. Evidence of Free and Bound LepUn in Human CirculaUon: Physiological significance in lean and obese subjects and during short-‐term fasUng. J. Clin. Invest. 98:1277,1996.
145. Nolan, J., J. Olefsky, M.R. Nyce, R.V. Considine and J.F. Caro. Effect of Troglitazone on LepUn ProducUon: Studies in vitro and in human subjects. Diabetes. 45:1276,1996.
146. Hickey, M., R.V. Considine, R. Israel, M. McCammon, G. Tyndall, T. Mahar, J. Houmard and J.F. Caro. LepUn is related to body fat content in male distance runners. Am. J. Physiol. 271:E938,1996.
147. Caro, J.F., J.W. Kolaczynski, M.R. Nyce, J.P. Ohannesian, I. Opentanova, W.H. Goldman, R.B. Lynn, P.L. Zhang, M.K. Sinha, and R.V. Considine. Decreased CSF/Serum lepUn raUo in human obesity: A possible mechanism for "apparent" lepUn resistance. Lancet. 348:159,1996.
148. Caro, J.F., M.K. Sinha, J.W. Kolaczynski, P.L. Zhang, and R.V. Considine. LepUn: The Tale of an obesity gene. Diabetes 45:1455,1996
149. Sinha, M.K., J. Sturis, J. Ohannesian, S. Magosin, T. Stephens, M.L. Heiman, K.S. Polonsky, and J.F. Caro. Ultradian OscillaUons of LepUn SecreUon in Humans. Biochem. Biophy. Res. Commun. 228:733,1996.
150. Hickey, M. S., R. G. Israel, S. N. Gardiner, R. V. Considine, M. R. McCammon, G. L. Tyndall, J. A. Houmard, R. H. L. Marks, and J. F. Caro. Gender Differences in Serum LepUn Levels in Humans. Biochem. Mol. Med. 59:1,1996.
151. Kolaczynski, J. W., and J. F. Caro. Tolerance in Individuals with Diabetes. Chapter 10. The Clinical EvaluaUon of a Food AddiUve, CRC Press,1996.
152. Kolaczynski, J.W., J. P. Ohannesian, R. V. Considine, C. C. Marco, and J. F. Caro. Response of LepUn to Short-‐Term and Prolonged Overfeeding in Humans. J. Clin. Endo. Metab. 81:4162,1996.
153. Kennedy, J. W. and J. F. Caro. The ABCs of Managing Hyperthyroidism in the Older PaUent. Geriatrics. 51:22,1996.
154. Wing, R. R., M. K. Sinha, R. V. Considine, W. Lang and J. F. Caro. RelaUonship between Weight Loss Maintenance and Changes in Serum LepUn Levels. Horm. Metab. Res. 28:698,1996.
155. Considine, R. V., and J. F. Caro. LepUn: Genes, Concepts and Clinical PerspecUve. Horm. Metab. Res. 46:249,1997.
156. Considine, R. V., M. R. Nyce, J. W. Kolaczynski, P. Zhang, J. P. Ohannesian, J. H. Moore, Jr., J. W. Fox, and J. F. Caro. Dexamethasone sUmulates lepUn release from human adipocytes: Unexpected inhibiUon by insulin. J. Cell. Biochem. 65:254,1997.
157. Hickey, M. S, J. A. Houmard, R. V. Considine, G. L. Tyndall, J. B. Midgeoe, K. E. Gavigan, L. Weidner, M. R. McCammon, R. G. Israel, and J. F. Caro. Gender-‐dependent effects of exercise training on serum lepUn levels in humans. Am. Physiol. Soc. E562,1997.
158. Caro, J.F. LepUn is Normal in PCOS, an Editorial about 3 “NegaUve” Papers. J. Clin. Endo. & Metab. 82:1685,1997.
159. Casanueva, F.F., C. Dieguez, V. Popovic, R. Peino, R. Considine, and J.F. Caro. Serum immunoreacUve-‐lepUn concentraUons in paUents with anorexia nervosa before and aser parUal weight recovery. 1997. Biochem. and Mol. Med. 60:116,1997.
160. Sreenan, Seamus, J. F. Caro, and S. Refetoff. Thyroid DysfuncUon is not Associated with AlteraUons in Serum LepUn Levels. Thyroid. 7:407,1997.
161. Considine, R. V. and .J. F. Caro. LepUn and the RegulaUon of Body Weight. Int. J. Biochem. Cell Biol. 29:1255,1997.
162. Hickey, M.S., J. A. Houmard, R. V. Considine, G. L. Tyndall, J. B. Midyeoe, K. E. Gavigan, M. L., Weidner, M. R. McCammon, R. G. Israel, and J. F. Caro. Exercise training improves insulin acUon but does not change serum lepUn levels in obese humans. Amer. J. Physiol. 59:1,1997.
163. Sharma, K., R. Considine, B. Michael, S. Dunn, L. Weisberg, B. Kurnik, P. Kurnik, J. O’Connor, M. Sinha and J. F. Caro. Plasma LepUn is Cleared by the Kidney and is Markedly Elevated in emodialysis PaUents. Kidney Int. 51:1980,1997.
164. Caro, J. F., Sinha, M. K., Kolaczynski, J. W., Zhang, P., Considine, R. V. LepUn: The tale of an obesity gene. LepUn as alternaUve treatment for human obesity. BioMedicina,1997.
165. Vidal-‐Puig, Antonio J., R. V. Considine, Mercedes Jimenez-‐Linan, Ariel Werman, Walter J. Pories, Jose F. Caro, and Jeffrey Flier. Peroxisome Proliferator -‐ acUvated receptor Gene Expression in Human Tissues Effects of Obesity, Weight Loss, and RegulaUon by Insulin and GlucocorUcoids. J. Clin. Invest. 99:2416,1997.
166. Schoeller, D. A., Cella, L. K., Sinha, M. K. , and Caro, J. F. Entrainment of the Diurnal Rhythm of Plasma LepUn to Meal Timing. J. Clin. Invest. 100:1882,1997.
167. Wadden, T. A., R. V. Considine, G. D. Foster, D. A. Anderson, D. B. Sarwer, and J. F. Caro. Short-‐ and Long-‐Term Changes in Serum LepUn in DieUng Obese Women: Effects of Caloric RestricUon and Weight Loss. J. Clin. Endo. & Meta. 83:214,1998.
168. Sinha, M. K. and J. F. Caro. Clinical Aspects of LepUn. Vitam. Horm. 54:1,1998 169. MarUn, L.J., .P.J.H. Jones, R.V. Considine, W. Su, N.F. Boyd and J.F. Caro. Serum LepUn Levels and Energy
Expenditure in Normal Weight Women. Can. J. Physiol. Pharmacol. 76:237,1998. 170. Stephens, T. W. and Caro, J. F. To be Lean or not to be Lean, Is LepUn the Answer? Exp. Clin. Endocrinol.
106:1,1998. 171. Caro, J.F. LepUn: From 1958 to the Present. Can. J. Diab. Care. 22:518,1998 172. Hickey, Maohew S., Pories, Walter J., Macdonald, Kenneth G., Cory, Kelly A., Dohm, G. Lynis, Swanson,
Melvin S., Israel, Richard G., Considine, Robert V., Caro, Jose F., Houmard, Joseph A. A New Paradigm for Type 2 Diabetes Mellitus: Could it be a Disease of the Forgut? Ann. Surg. 227:637,1998.
173. Heini, AF, Lara-‐Castro, C, Kirk, KA, Considine, RV, Caro, JF, and RL Weinsier. AssociaUon of lepUn and hunger-‐saUety raUngs in obese women. Int. J. Obes. Relat. Metab. Disord. 22:1084,1998.
174. Heiman, M. L., Chen, Yanyun, and Caro, J.F. LepUn parUcipates in the regulaUon of glucocorUcoid and growth hormone axes. J. Nutr. Biochem. 9:553,1998.
175. Lage, M., R. V. Garcia-‐Mayor, M. A. Tome, F. Cordido, F. Valle-‐Inclan, R. V. Considine, J. F. Caro, C. Dieguez, F. F. Casanueva. Serum lepUn levels in women throughout pregnancy and the postpartum period and in women suffering spontaneous aborUon. Clin.Endocrinol. 50:211,1999.
176. Considine, R. V. and J. F. Caro. Pleiotropic cellular effects of lepUn. Curr Opin in Endocrinol and Diab. 6:163,1999.
177. Heiman, M. L., Sloop, K. W., Chen, Y. and J. F. Caro. Extension of Neuroendocrine Axes to Include LepUn. J. Anim. Sci. 77:33,1999.
178. Goldstein, D. J. and J. F. Caro. GeneUcs and PotenUal Treatments for Obesity. The Management of EaUng Disorders, Chapter 18. Humana Press, Inc., 1999.
179. Ohannesian, J.P., Marco, C.C., Najm, P.S., Goldstein, B.J., Caro, J. F., and J.W. Kolaczynski. Small Weight Gain is not Associated with Development of Insulin Resistance in Healthy, Physically AcUve Individuals. Horm. Metab. Res. 31:323, 1999.
180. Kolaczynski, J. W. and J. F. Caro. Insulin Resistance: Site of the Primary Defect or How the Current and the Emerging Therapies Work. J. Basic & Clin. Physiol. & Pharmacol.281, 1999.
181. Caro, J.F. Obesity. In: McGraw-‐Hill. Yearbook of Science & Technology, 2000. 182. Corominola, H., L.J. Conner, L.S. Beavers, R.A. Gadski, D. Johnson, J. Sluka, J.F. Caro and R. Rafaeloff-‐Phail.
IdenUficaUon of Novel Genes DifferenUally Expressed in Omental Fat of Obese and Obese Type 2 DiabeUc PaUents. Diabetes 50:2822, 2001
183. Caro, J. F. and M. Trautmann. LepUn: The Adipocyte Signal in the Control of Body Weight. In: Handbook of Experimental Pharmacology, 2000.
184. Dananberg, J. and J.F. Caro. Obesity. In: Endocrinology. L.J. DeGroot, (Ed.), W. B. Saunders, 2000. 185. Caro, J.F. and L.E. Stramm. Biochemical Defects of Insulin AcUon in Humans. In: Diabetes Mellitus. D.
LeRoith, S.I. Taylor, and J.M. Olefsky, (Eds.), Lippincoo-‐Ravin, 2000. 186. Statnick, M.A., L.S. Beavers, L.J. Conner, H. Corominola, D. Johnson, C.D. Hammond, R. Rafaeloff-‐Phael,
T.Seng, T.Suter, J.P. Sluka, E. Ravussin R.A. Gadski, and J.F. Caro. Decreased Expression of apM1 in Omental and Subcutaneous Adipose Tissue of Humans with Type 2 Diabetes. Int. J. Exp. Diabetes Res., 2000.
187. Caro, J.F. and M.E. Trautmann. LepUn: The Adipocyte Signal in the Control of Body Weight. In: Obesity: Pathology and Therapy. T.G. Heffner and D.H. Lockwood, (Eds.), Springer-‐Verlag, 2000.
188. Caro, J.F., R.V. Considine. Handbook of Obesity, Chapter 59. G. Bray and C. Bouchard (Eds), M. Decker and Co., 2001
189. Rohner-‐Jeanrenaud, F., L. S. Cras, J. Bridwell, T. M. Suter, F. C. Tinsley, D. L. Smiley, D.R. Burkhart, M.A. Statnick, M.L. Heiman, E.R. Ravussin, and J.F. Caro. Chronic central CART infusion decreases body weight and increases lipid oxidaUon in lean and high fat fed obese rats. Int J Obes Relat Metab Disord. Feb; 26(2):143-‐9,2002.
190. Diabetes PrevenUon Program Research Group. ReducUon in the Incidence of Type 2 Diabetes with Lifestyle IntervenUon or Melormin. New Engl J Med. 346:393,2002.
191. Moyers, J.S. and Caro, J.F. Insulin Resistance – Emerging Therapies for Affect Sites.In Insulin Resistance and Insulin Resistance Syndrome, FronUers in Animal Diabetes, editedby B.C. Hansen and E. Shafrir. pp 313-‐333, Taylor & Francis Publisher, NY 2003.
192. Caro, J.F. Health ImplicaUon, DefiniUons and ClassificaUon of Obesity. In: Endotext.com. 2004
193. Etgen, G.J., M.J. Prince, J.F. Caro. Peroxisome Proliferator-‐AcUvated Receptor Modulators. In: Diabetes Mellitu: A Fundamental and Clinical Text. D. LeRoith, S.I. Taylor, and J.M. Olefsky, (Eds.), Lippincoo Williams & Wilkins, 2004.
194. Caro, J.F., R.V. Considine. Handbook of Obesity, Chapter 59. G. Bray and C. Bouchard (Eds.), M. Decker and Co., 2004
195. Caro, J.F. and Dananberg, J. Obesity: The Problem and its Management. In: Endocrinology. L.J. DeGroot, and J.L. Jameson (Ed). Elsevier, Saunders, 2005.
196. Serrano Rios, M. Caro, J. F., Carraro, C., GuUerrez Fuentes, J.A. IntroducUon In: The Metabolic Syndrome at the Beginning of the XXI Century A geneUc and MolecularApproach. ELSEVIER. 2006
197. Peer Support Programmes in Diabetes. Advisor and Member of the OrganizaUon Commioee. Report of
WHO consultaUon, 5-‐7 November 2007. PublicaUon WHO/CPM/08/01
198 Caro, J.F. On the Trail to Arrest the Progression of the Metabolic Syndrome. Endocrinol Nutr. 54 Supl 4: 37, 2007
199 Caro, J.F., Rosas, J. Diabetes and Depression: IniUal QuesUons. Journal of ALAD, 16: 50, 2008
200 Considine, R. and Caro, J.F. Obesity: The Problem and its Management. In: Endocrinology. L.J. DeGroot, and J.L. Jameson (Ed). Elsevier, Saunders, 2010
201 Caro, J.F. and Fisher E. Editorial. A SoluUon Might be Within People with Diabetes Themselves. Family Medicine, Supp 1: i1, 2010
202 Diabetes PrevenUon Program Research Group . GeneUc ModulaUon of Lipid Profile Following Lifestyle ModificaUon or Melormin Treatment: The Diabetes PrevenUon program. PLoS Genet. 8(8):e1002895, 2010
ABSTRACTS PRESENTED (incomplete list)
1. Caro, J.F., A. Besarab, J.F. Burke, and J.A. Glennon. 1978. Propranolol: A possible role in the treatment of renal osteodystrophy. American College of Physicians Eastern Pennsylvania Regional MeeUng.
1. Caro, J.F., J.A. Glennon, and H.L. Israel. 1978. Neuroendocrine studies in sarcoidosis 8th InternaUonal Congress of Sarcoidosis, Cardiff.
2. Caro, J.F., and P.D. Woolf. 1979. HyperprolacUnemia diminishes pituitary LH reserve but no ovarian responsiUvity to GnRH infusion. The Endocrine Society 61st Annual MeeUng.
3. Besarab, A., J.F. Caro, B.U. Ihle, and J.F. Burke. 1979. Beta-‐adrenergic blockade and hyperparathyroidism in chronic renal failure. Clin. Res., Eastern SecUon.
4. Caro, J.F., and J.M. Amatruda. 1979. The effect of fasUng on glucagon acUon and binding isolated rat hepatocytes. Clin. Res., Midwest SecUon.
5. Caro, J.F., and J.M. Amatruda. 1980. Insulin-‐mimickers down regulate the insulin receptor: Evidence for a post receptor mechanism. Amer. Diab. Assoc., 40th Annual MeeUng, Diabetes 29:38A.
6. Caro, J.F., and J.M. Amatruda. 1980. Insulin receptor anUbodies modulate insulin acUon and degradaUon independently of binding. The Endocrine Society 62nd Annual MeeUng.
7. Caro, J.F., J.M. Amatruda. 1980. Post receptor events regulate the insulin receptor. Amer. Diab. Assoc., 41st Annual MeeUng, Diabetes 30:9A.
8. Caro, J.F., G. Muller, and J.A. Glennon. 1982. Insulin processing by the liver. Amer. Diab. Assoc., 42nd Annual MeeUng, Diabetes 31:133A.
9. Kauffman, J.M., G. Muller, and J.F. Caro. 1982. Mechanism of insulin resistance in rat hepatocytes: a new model of chronic uremia. Amer. Diab. Assoc., 42nd Annual MeeUng. Diabetes 31:124A.
10. Caro, J.F., F. Cecchin, and M. Sinha. 1983. Is cell glycosylaUon needed for insulin binding and post binding events? Amer. Diab. Assoc., 43rd Annual MeeUng. Diabetes 32:32A.
11. Caro, J.F., and S. Lanza-‐Jacoby. 1983. Insulin resistance in uremia: the role of the liver. The Endocrine Society, 65th Annual MeeUng.
12. Caro, J.F., F. Cecchin, F. Folli, and M. Sinha. 1983. Triiodothyronine-‐induced insulin resistance in primary cultures of rat hepatocytes. European Thyroid AssociaUon, XII Annual MeeUng. Annales, d endocrinology, 44:87A.
13. Caro., J.F., F. Folli, M. Sinha, and D. Brancaccio. 1984. Insulin resistance in uremia: in vitro model to study mechanism(s) in the liver. Amer. Diab. Assoc. 44th Annual MeeUng. Diabetes 38:138A.
14. Sinha, M.K., and J.F. Caro. 1984. Insulin mediator in serum? RecogniUon of an arUfact. Amer. Diab. Assoc. 44th Annual MeeUng. Diabetes 38:140A.
15. Caro, J.F., O. Iooop, and M.K. Sinha. 1984. Tolazamide and glyburide but not ciglytazone enhance insulin acUon in the liver. 7th InternaUonal Congress of Endocrinology.
16. Caro, J.F., M.K. Sinha, M.L. McCaleb, G.B. Wish, and D.H. Lockwood. 1985. Insulin resistance in uremia is due to a post insulin receptor kinase defect(s). Clin. Res. 33:426A.
17. Sinha, M.K., O.Iooop, and J.F. Caro. 1985. Enhanced insulin receptor kinase acUvity in a paUent with extreme insulin resistance and acanthosis nigricans. Clin. Res. 33:444A.
18. Caro, J.F., O. Iooop, W. Pories, R. Dudek, and M.K. Sinha. 1985. Insulin responsive human hepatocytes. Amer. Diab. Assoc. 45th Annual MeeUng. Diabetes 34:50A.
19. Sinha, M.K., O. Iooop, M. Jenquin, and J.F. Caro. 1985. Effect of down-‐regulaUon and tunicamycin on insulin receptor autophosphorylaUon and kinase acUvity. Amer. Diab. Assoc. 95th Annual MeeUng. Diabetes 34:159A.
20. Dohm, G.L., J.F. Caro, and M.K. Sinha. 1985. Insulin receptors and insulin receptor protein kinase acUvity in muscle of endurance trained rats. Medicine and Science in Sport and Exercise 17:240.
21. Caro, J.F., F. Cecchin, F. Kasperek, M. Jenquin, O. Iooop, and M.K. Sinha. 1985. Insulin resistance in uremia: insulin receptor kinase acUvity in liver and muscle is different. XII Congress of the InternaUonal Diabetes FoundaUon.
22. Caro, J.F., G.L. Dohm, and M.K. Sinha. 1985. Insulin resistance in uremia: decreased hepaUc fructose 2,6-‐bisphosphate. XXI Congress of the InternaUonal Diabetes FederaUon.
23. Caro, J.F., W. Pories, O. Iooop, M. Jenquin, H.D. Meelheim, E. Flickinger, J.F. Silverman, F. Thomas, M.K. Sinha. 1985. Mechanism of insulin resistance in isolated hepatocytes from morbidly obese paUents with NIDDM. Int. J. of Obesity 9:A15.
24. Sinha, M.K., W. Pories, M. Jenquin, O. Iooop, H.D. Meelheim, E. Flickinger, J.F. Caro. 1985. Down regulaUon of insulin receptors and insulin acUon in cultured adipocytes from morbidly obese paUents with or without NIDDM. Int. J. of Obesity 9:A95.
25. Caro, J.F., M.K. Sinha, and I.D. Goldfine. 1986. Monoclonal anUbodies to the human insulin receptor that acUvate glucose transport but not insulin receptor kinase acUvity. III InternaUonal Symposium on Insulin Receptors and Insulin AcUon. Madrid, Spain.
26. Caro, J.F., O. Iooop, W. Pories, D. Meelheim, and M.K. Sinha. 1986. Studies on the mechanism of insulin resistance in the liver from humans with Noninsulin-‐dependent Diabetes: insulin acUon and binding in isolated hepatocytes, insulin receptor structure and kinase acUvity. III InternaUonal Symposium on Insulin Receptors and Insulin AcUon. Madrid, Spain.
27. Dvornik, D., R. Gonzales, D. Hicks, T. Smith, S. Ryder, J.F. Mullane, P. Raskin, J. Rosenstock, P. Challis, J. Caro, and W. Fore. 1985. Effect of tolrestat on RBC sorbitol levels in subjects with diabetes mellitus. Diabetes Research and Clinical PracUce. Supplement I:S146.
28. Silverman, J.F., D.J. Dabbs, K.F. O'Brien, H.T. Norris, and J. Caro. 1987. Liver pathology in morbid obesity. Laboratory InvesUgaUon. 56:IA.
29. Pories, W.J., J.F. Caro, E.G. Flickinger, H.D. Meelheim, and M.S. Swanson. 1987. The control of diabetes mellitus (NIDDM) in the morbidly obese with the Greenville gastric bypass operaUon. 107th MeeUng of the American Surgical AssociaUon.
30. Caro, J.F., S.I. Taylor, O. Iooop, S.M. Raju, and W.J. Pories. 1987. Endogenous substrates of insulin receptor kinase in human liver plasma membranes: defect(s) in NIDDM. The Endocrine Society.
31. Sinha, M.K., W.J. Pories, E. Flickinger, D. Meelheim, S. Atkinson, N.S. Sehgal, and J.F. Caro. 1987. Insulin worsens the insulin resistance of adipocytes in primary culture from obese and NIDDM subjects. The 69th Annual MeeUng of the Endocrine Society, Indianapolis.
32. Caro, J.F., M.K. Sinha, S.M. Raju, O. Iooop, W.J. Pories, D. Meelheim, E. Flickinger, and G.L. Dohm. 1987. Insulin receptors and insulin receptor kinase acUvity in human skeletal muscle from obese subjects with and without NIDDM. American Diabetes AssociaUon, 47th ScienUfic Sessions MeeUng, Indianapolis.
33. Forsayeth, J.R., J.F. Caro, M.K. Sinha, B.A. Maddux, and I.D. Goldfine. 1987. Monoclonal anUbodies to the human insulin receptor acUvate glucose transport but not insulin receptor kinase acUvity. Clinical Research 35:622A.
34. Caro, J.F., S.M. Raju, M.K. Sinha, I.D., Goldfine, and G.L. Dohm. 1988. Heterogeneity of human liver, muscle, and adipose Ussue insulin. Clinical Research 36:479A.
35. Caro, J.F., A. Rovira, J.J. Chen, N. Leggeo, K. O'Brien, C. Sash, K. Parker, F. Thomas, and G. L. Dohm. 1988. Insulin resistance in the skeletal muscle of uremic paUents is a post insulin receptor kinase defect(s). Clinical Research 36:479A.
36. Caro, J.F., J. Poulos, O. Iooop, N. Mooney, and M.K. Sinha. 1988. Insulin-‐like growth factor I receptors in hepatocytes from human liver, human hepatoma and normal, regeneraUng and fetal rat liver. Clinical Research 36:479A.
37. Dohm, G.L., C.W. Elton, W. J. Pories, E.C. Flickinger, S.M. Atkinson, and J.F. Caro. 1988. Changes in glucose transport and insulin sensiUvity of in vitro incubated human muscle from obese and diabeUc subjects. The FASEB Journal, Vol. 2, No. 5.
38. Sinha, M.K., C. Buchanan, L. MarUn, R. DiMarchi, and J.F. Caro. 1988. Insight into the mechanism of 16F-‐1 sUmulated glucose transport in human fat cells. The Endocrinology Society Program and Abstracts, 70th Annual MeeUng, 517.
39. Chen, J.J., N. Leggeo, W. Pories, E. Flickinger, K. O'Brien, P. Khazanie, and J.F. Caro. 1988. Noninsulin dependent diabetes mellitus worsens the severe insulin resistance of morbid obesity. The Endocrinology Society Program and Abstracts, 70th Annual MeeUng, 1105.
40. Thakkar, J.K., R. DiMarchi, and J.F. Caro. 1988. Insulin, IGF-‐I and IGF-‐II do not sUmulate phosphaUdylinositol-‐4, 5-‐biphosphate specific-‐phospholipase C in human liver. Diabetes Program 48th Annual MeeUng, 114.
41. Sinha, M.K., C. Buchanan, L. MarUn, R. DiMarchi, and J.F. Caro. 1988. Presence of IGF-‐II receptors and IGF-‐II sUmulaUon of glucose metabolism in human adipocytes. Diabetes Program 48th Annual MeeUng, 729.
42. O'Brien, K.F., T.C. Chen, T.C. Chenier, and J.F. Caro. 1988. Using oral glucose tolerance test to evaluate glucose uptake, insulin release, and resistance. Eastern North American Regional Biometrics Society, Boston, Massachuseos.
43. Pories, W.J., E.G. Flickenger, K.G. MacDonald, and J.F. Caro. October 1989. Long Term effect of the gastric bypass operaUon on weight, diabetes, hypertension, and mental health in the morbidly obese. Clinical Congress, American College of Surgeons, Atlanta, Georgia.
44. Thomas, F., W. Costellani, C. Sash, H. Daniel, L. Dabuey, P. Cunningham, A. Ferguson, and J.F. Caro. 1989. Studies of radioimmunescence reacUve urinary insulin in humans. New Test for Diagnosis of Pancreas RejecUon. First InternaUonal Congress of PancreaUc and Islet TransplanUng. Diabetes 38(Sup 1):253.
45. Dunham, D., S. Marcuard, A. Hobbs, and J.F. Caro. 1989. Availability of insulin from total parenteral nutriUon (TPN) soluUons. 13th Clinical Congress Abstracts. JPEN 13(Supp)1:8S.
46. Caro, J.F., M.K. Sinha, and G.L. Dohm. Insulin Resistance. 1989. J. Cell Biochemistry (Supp 13E):224.
47. Dohm, G.L., C.W. Elton, S.M. Raju, N. Mooney, R. Dimarchi, W.J. Pories, E.G. Flickinger, S.M. Atkinson, and J.F. Caro. 1989. IGF-‐I and IGF-‐II sUmulated glucose transport in human skeletal muscle: IGF resistance in obesity and NIDDM. Diabetes, 49th Annual MeeUng, 50A.
48. Sinha, M.K., C. Buchanan, C. Raineri-‐Maldonado, P. Khazanie, W.J. Pories, R. Dimarchi and J.F. Caro. IGF-‐I SUmulated glucose transport, IGF-‐I receptors and tyrosine kinase are not altered as noted for insulin in adipocytes from NIDDM paUents. Diabetes, 49th Annual MeeUng, 103A.
49. Elton, C.W., E.B. Tapscoo, J.F. Caro, P.F. Pilch, W.J. Pories, S.M. Atkinson, and G.L. Dohm. 1989. "Effect of moderate obesity on glucose transport in human muscle." Int. J. Obes., 1989 Annual MeeUng of the North American AssociaUon for the Socity of Obesity.
50. Caro, J.F., S.M. Raju, N. Leggeo-‐Frazier, L. Roy, S. Long, and K. O'Brien. 1990. "Altered coupling of the insulin receptor with Gi protein in the liver from paUents with NIDDM." ADA 50th Annual MeeUng and ScienUfic Sessions.
51. Caro, J.F., M.K. Sinha and G.L. Dohm. Insulin resistance in obesity. 1990. Int. J. Obes. (Supp) 2:28.
52. Caro, J.F., M.K. Sinha, G.L. Dohm. July 1990. AlteraUons in insulin receptors and glucose transporters in obese and diabeUc man. Fundamental and Clinical Pharmacology 4 (Supp)1:10S. Pathophysiology and Treatment of Diabetes Melllitus (Satellite MeeUng of the Amsterdam XIth InternaUonal Congress of Pharmacology), Montpellier, France.
53. Marcuard, S.P., B. Dunham, M.K. Sinha, S.J. Raju, J.F. Caro., May 1991. Insulin binds to heparinin TPN soluUons. American Gastroenterological AssociaUon, New Orleans, Louisiana.
54. Caro, J.F., M.K. Sinha, W.J. Pories, H.A. Barakat, P.G. Khazanie, G.L. Dohm. 1991. J Cell Bioch. (Supp. 15B):13, CA023.
55. Burguera B., R.K. Stanzak, L.J. Slieker, W.F. Health, N. Leggeo-‐Frazier, L. Roy, S. Long, and J.F. Caro. 1991. Is the low level of GLUT-‐2 gene expression present in impaired glucose tolerant paUents (IGT) prevenUng or inducing non-‐insulin dependent diabetes mellitus (NIDDM)? 73rd Annual MeeUng, The Endocrine Society, #1765, pg. 472
56. Friedman, J.E., W.J. Pories, N. Leggeo-‐Frazier, L.L. Roy, S.D. Long, J.F. Caro, and G.L Dohm. 1991. Evidence for decreased insulin sensiUve glucose transporters (GLUT 4) in skeletal muscle for a large sample of obese and obese-‐NIDDM paUents. ADA 51st Annual MeeUng and ScienUfic Sessions. Diabetes #630.
57. Sinha, M.K., T. Madigan, G. Cooper, and J.F. Caro. 1991. Effect of amylin and calcitonin gene related pepUde-‐1 (CGRP-‐1) on glucose transport in isolated adipocytes from lean, obese and NIDDM paUents. ADA 51st Annual MeeUng and ScienUfic Sessions. Diabetes #955, pg. 239A.
58. Barakat, H.A., K. O'Brien, S. Long, P. Khazanie, W. Pories, and J. Caro. 1991. Coronary artery disease risk factors in morbidly obese women with normal glucose tolerance. ADA 51st Annual MeeUng and ScienUfic Sessions. Diabetes #1711, pg. 429A.
59. MacDonald, K.G., W.J. Pories, C.A. Moore, N. Leggeo-‐Frazier, C. Jone, S. Long, E. Morgan, L. Roy, J.F. Caro. 1992. The reversal of diabetes mellitus (DM) with gastric bypass: correlaUon of duraUon of diabetes with glucose response and insulin release. Annual MeeUng, American Society for Bariatric Surgery, New Orleans.
60. Ravindra, R., J.F. Caro. 1992. Insulin sUmulates GDP release from G proteins in the rat and human liver. 74th Annual MeeUng, The Endocrine Society, Texas, #23, pg. 57.
61. Long, S.D., K. O'Brien, M. Swanson, K. MacDonald, N. Frazier, W.J. Pories, J.F.Caro. 1992. Weight loss prevents the progression of impaired glucose tolerance to non-‐insulin dependent diabetes mellitus: A ten year longitudinal study. 52nd Annual MeeUng, Diabetes #266. pg. 72A.
62. Ravindra, R. and Caro, J. 1993. Effect of Glucagon on GDP release from G Proteins in the rat liver plasma membranes. 75th Annual MeeUng, The Endocrine Society #526. pg. 182.
63. Moore, J.H., Kolaczynski, J.W., Morales, L.M., Considine, R.V., Pietrzkowski, Z., Noto, P.F. and Caro, J.F. 1993. Viability of fat obtained by syringe sucUon lipectomy: Effects of local anesthesia with Lidocaine. The Lipoplasty Society of North America, Inc., Annual MeeUng, New Orleans.
64. Considine, R.V., Allen, L., Nyce, M., Noto, P., Triester, S., Morales, L.M. and Caro, J.F. 1994. Membrane protein kinase C is increased in NIDDM liver. Studies of PKC isozyme distribuUon in both humans and a rat model. 54th Annual MeeUng, American Diabetes AssociaUon, New Orleans.
65. Swanson, S., Long, E., Smith, K., MacDonald, G., Dohm, N., Frazier, J. Caro, J and Pories W. 1994. Early gastric bypass provides beoer control of NIDDM in the morbidly obese. 7th ICO Satellite Symposium, Surgical Treatment of Obesity, Montreal, Quebec
66. Koda, J.E., Fineman, M.S., O.G. Kolterman, and Caro, J.F. 1995. 24 Hour Plasma Amylin Profiles are Elevated in IGT Subjects vs. Normal Controls. 55th Annual MeeUng and ScienUfic Sessions American Diabetes AssociaUon, Atlanta, Georgia, Diabetes #876, pg. 45A.
67. Spiegelman, B.M., P. Arner, J.F. Caro, R.L. Atkinson and G.S. Hotamisligil. 1995. ElevaUon of Adipose Tissue Expression of TNFα and TNF Receptors in Human Obesity and Insulin Resistance. 55th Annual MeeUng and ScienUfic Sessions American Diabetes AssociaUon, Aoanta, Georgia, Diabetes #164, pg. 45A.
68. Considine, R.V., E.L. Considine, C.J. Williams, M. Nyce, S.A. Magosin, T.L. Bauer, E.L. Rosato, J. Colberg and J.F. Caro. 1995. Ob Gene Expression is Increased in Adipocytes from Obese Humans. 55th Annual MeeUng and ScienUfic Sessions, Atlanta, Georgia, Diabetes #739, pg. 202A..
69. Heini, A.F., R.V. Considine, J.F. Caro, H. Schneider, and R.L. Weinsier. 1996. The Effect of a Hydrolyzed Guar Fiber on FasUng and Postprandial Glucose Metabolism, Cholecystokinin, LepUn and SaUety. XVIII ESPEN Congress, Geneva, Switzerland.
70. Heini, A.F., C. Lara-‐Castro, R.V. Considine, J.F. Caro, and R. L. Weinsier. 1996. LepUn and SaUety in obese women. XVIII ESPEN Congress, Geneva, Switzerland
71. Schoeller, D.A., Cella, L. Kessler, Sinha, M., and Caro, J.F. 1996. Entrainment of the Diurnal VariaUon in Plasma LepUn Levels. North American AssociaUon for the Study of Obesity.Breckenridge, Colorado
72. Israel, R.G., M.S. Hickey, R.V. Considine, T.L. Mahar, M.R. McCammmon, G.L. Tyndall, J.A. Houmard, and J. F. Caro. 1996. LepUn is Related to Fat Mass in Highly Trained Endurance Runners. North American AssociaUon for the Study of Obesity. Breckendridge, Colorado
73. Wauters, M., R. Considine, C. Van Broeckhoven, I. De Leeuw, J. Caro, L. Van Gaal. 1996. AssociaUons of LepUn with Body ComposiUon are Influenced by Apoe Polymorphism in NIDDM PaUents. North American AssociaUon for the Study of Obesity. Breckenridge, Colorado
74. LeUexhe, M.R., A. J. Scheen, J.F. Caro and P.J. Lefebvre. 1997. Post-‐Gastroplasty Recovery of Ideal Body Weight Normalizes Serum LepUn Levels of Obese Women. Diabetologia. 40:A263
75. LeUexhe, M.R., A.J. Scheen, F. Sodoyez-‐Goffaux, J.F. Caro and P.J. Lefebvre. 1997. RelaUonships between Basal Plasma LepUn, FasUng Total or True Insulin Levels, and Insulin SensiUvity Index S1 in Lean, Oese and Post-‐Obese Females. InternaUonal Journal of Obesity. 21:(Suppl.2). S101
76. Zhang, P.L., J.D. Liang, G.E. Sandusky, B. Burguera, R,V. Considine, T.M. Hyde, H.M. Hsiung, P.R. Sankhavaran, M.A. Esterman, E. Maratos-‐Flier and J.F. Caro. 1998. Hypothalamic MCH mRNA and Protein are Increased in Human Obesity. GeneUc and Molecular Basis of Obesity, Satellite Symposium of the 8th InternaUonal Congress on Obesity. Paris, France.
77. Statnick, M.A., P.L. Zhang, C. Hammond, L. Beavers, L.J. Conner, D. Johnson, T.M. Suter, R. Gadski and J.F. Caro, 1998. Expression of SOCS3, An Inhibitor of LepUn Signaling, is not Altered in the anterior Hypothalamus of Obese Humans. GeneUc and Molecular Basis of Obesity, Satellite Symposium of the 8th InternaUonal Congress on Obesity. Paris, France.
78. Woodworth, J.R., D.C. Howey, R.R. Bowsher, M.E. Trautmann and J.F. Caro 1998. The PharmacokineUcs and Acute Effects of LY355101, a Novel AnU-‐obesity Protein, in Healthy Volunteers. GeneUcs and Molecular Basis of Obesity, Satellite Symposium
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