Joint Power 24Presented by Peter Jo, Rph

President Super Value Nutraceuticals, Corp.

Nutritional Therapies of Arthritis

The number-one disability in US Joint disorders aren’t fatal

- only minimal scientific research compared to heart disease, cancer, and AIDS. Because of the lack of real concern,Physicians who have to treat their arthritis patients with less-than-ideal methods.

Arthritis

There is an enormous information about the role of nutrients play in healing joints. But somehow, this information has not much been utilized in America.

In several European countries- some nutrients now are the drugs of choice for the treatment of osteoarthritis.

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Ignorance of Nutrients and their roles

70 million adults reported by CDC (43 million diagnosed by doctors) CDC estimates adding 22 million by 2030

Arthritis Patient Population

The story of “Vitamin I” (myth of Ibuprofen)

Risk all sorts of complications (high BP, heart attacks, strokes,

GI bleeding, etc) Some drugs may even make

arthritis worse.

Problems of Conventional drugs

Overnight heroes turns out the devils which destroy the whole body. (long term use)

Side effects: from Bone deterioration to Weight gain

Corticosteroids

Next roller-coaster riding after corticosteroids (100 years up and down since Aspirin)

Indomethacin, Sulindac, Piroxicam, Naproxen relay

NSAIDs

The British medical Journal in 2004 : A Shocking Discovery “NSAIDs can reduce short-term in osteoarthritis of the knee slightly better than placebo, but the current analysis does not support prolonged use of NSAIDs for this condition. As serious adverse effects are associated with oral NSAIDs, only limited use can be recommended.”

NSAIDs

1984 Rx-to-OTC switch started and OTC NSAIDs on the market.

People are gobbling down OTC NSAIDs almost like candy. (ex. Vitamin I)

The decision to make NSAIDs available OTC

was a blessing or a curse?

2005 Journal of Rheumatology “OTC analgesic including NSAIDs are widely used, are frequently taken inappropriately and potentially dangerously, and users are generally unaware of the potential for adverse side effects.”

The decision to make NSAIDs available OTC was

a blessing or a curse?

1999 Initial excitement of selective COX-2 inhibitors-Vioxx, Bextra, Celebrex

The danger of COX-2 inhibitors: an increased risk of blood clots.

The COX-2 Catastrophe: The Broken Promise

Until the fall of 2004: one of the darkest hours in the history of American medicine : More than 100,000 people suffered heart attack s and strokes. According to FDA safety officer David Graham, MD, as many as 40,000 people may have died.

First Vioxx and then Bextra were pulled off the market.

The COX-2 Catastrophe: The Broken Promise

To understand diseases of the joint, we need to look at normal healthy joint.

Joints are held together by joint capsule that is designed to allow smooth movement between adjacent bones.

The Normal Joint

The bone ends are covered by the cartilage over which the joint moves.

A synovial membrane which encloses the joint space secretes synovial fluid.

The Normal Joint

Arthritis: Inflammation of the joint: joint tissue response to mechanical, chemical, and immunological challenge.

Inflammation: Arachidonic acid products: prostaglandin(PGE-2) by cyclooxygenase(COX-2) and leukotriene(LTB4) by lipoxygenase(5-LOX)

Biochemical mechanisms of Arthritis

The Importance of Addressing All the Inflammatory Pathways

Arachidonic Acid Pathway

Dietary Factors

COX 2 5-Lipooxygenase

Prostaglandin E2 Leukotreine B4

Phospholipase A2

Arachidonic Acid

Willow Bark

Feverfew

Bromelain

Boswellia

1.Bromelain: reduce swelling, bruising, healing time, and pain following surgery and physical injuries.2.Boswellia:works by blocking 5-LOX, which is the first enzyme released in the metabolic pathway leading to the synthesis of the immune system cytokines known as leukotrienes.

Joint Power 24 Ingridients

3.Feverfew: The most common, scientifically documented benefit of feverfew extract is in the prophylactic treatment of migraine headaches. Folk remedies for arthritis and rheumatic pain4.Willow bark: used to ease pain and reduce inflammation. Researchers believe that salicin, found in willow barkis responsible for these effects.

5.Glucosamine: which is produced naturally in the body, plays a key role in building cartilage, the tough connective tissue that cushions the joints.6.Chondroitin: A major component of cartilage which helps to keep cartilage healthy by absorbing fluid into the connective tissue and provides the building blocks to produce new cartilage.

7.MSM:form connective tissue and slow the nerve impulses that transmit pain signals.8.Hyluronic acid: improve the mobility of osteoarthritis patients by alternations in the synovial fluid viscoelasticity, cartilage metabolism, and inflammation.