John Ramsey

John RamseyTICTAC Communications Ltd

St. George’s, University of London

London SW17 0RE

SEWPROF RoundtableSpain

New Psychoactive Substances in Wastewater

TICTAC’s contribution

• ER – Dr. Bram Miserez

• Discovery and characterisation of NPS

• Test purchases

• Amnesty bins

• Police seizures

• Prisons

• Pooled urine collection

• Dissemination of samples

• Analysis of results


TICTAC Communications Ltd.

Typical UK “head shop” offering April 2013

Rock Stars Tablet 5-MeO-DALT

Rockets Capsule Methylone

AMT Tablet AMT

Dutchy Herb 5F-AKB48, STS-135, MAM-2201

E-Scape Tablet 5-MAPB, 5/6-APB

Puff Adder Herb 5F-AKB48, AKB48

Chillem Blue Herb 5F-AKB48, AKB48

Poke Powder Methiopropamine, Dimethocaine

Dust Till Dawn Powder Benzocaine, Methiopropamine

Charly Sheen Powder Lidocaine, Methiopropamine, MDAI

Clockwork Orange Herb 5F-AKB48

Gogaine Powder Lidocaine, Methiopropamine, Ethylphenidate

Bomb Powder Methiopropamine, Benzocaine

Magic Crystals Powder Benzocaine, Caffeine, Ethylphenidate

China White Powder Methiopropamine, Benzocaine

Barry White Powder Methiopropamine, MDPV, Lidocaine, 2-Aminoindane

Blue Genie Tablet Methiopropamine, 5/6-APB

Jack and Jills Tablet Ethylphenidate

Disco Biscuts Tablet AMT

Green Beans Capsule Methiopropamine, 5/6-APB

6APB Capsule Ethylone

Blast Tablet 5-MeO-DALT

Fury Xtreme Capsule 5/6-APB, Methiopropamine

Pink Panters Capsule Methiopropamine

Purple Bomb Tablet Ethylphenidate, 5-Meo-DALT, Methiopropamine

Jumping Beans Tablet Methiopropamine

Matrix Fury Tablet Methoxetamine


Methiopropamine

AMT

Methylone

Ethylphenidate


Methylphenidate (Ritalin ®)

Ethylphenidate

3,4-CTMP

isoPropylphenidate

HDMP-28 (methylnaphthidate)


Methylphenidate derivatives

Methylphenidate

Ethylphenidate3,4-CTMP Methylnaphthidate

IsoPropylphenidate



This means that it will be unlawful to supply, possess

with intent to supply, produce, and import or export

ethylphenidate, 3,4-dichloromethylphenidate,

methylnaphthidate (HDMP-28), isopropylphenidate and

propylphenidate, and their simple derivatives, except

under licence issued by the Home Office.


new compounds

are used as drugs

because they fall

outside legislation

the law

catches up

The driver for change

The consequence is that vulnerable young people are exposed to a

succession of compounds that have never been tested for safety


The response ?

B2 / M1M

Propylhexedrine analogue (3,4-methdioxy variant)

1-(hexahydrobenzo[d][1,3]dioxol-5-yl)-N-methylpropan-2-amine

500g B2 - £1500 or 1kg B2 - £2500





Synthetic cannabinoids detected by TICTAC March 2015

5-fluoro NPB-22

5-fluoro AB-PINACA

THJ 018

JWH-018 indazole analog

SDB-006

5-fluoro MN-18

FUB-PB-22

EG 018

5-fluoro AMB


URB597

AM2201 benzimidazole analog

AB-PINACA

ADB-FUBINACA

URB754

THJ2201

A-836339

MDMB-CHMICA

MDMB-CHMINACA


URB754endogenous agonist of the central cannabinoid (CB1) receptor

A-836339higher affinity for the peripheral CB2 receptor

analgesic, anti-inflammatory, and anti-hyperalgesic effects in mice

MDMB-CHMICA

MDMB-CHMINACA

5F-AB-PINACA

31424

5F-AB-PINA

C18H25FN4O2

N

N

NH

O

O

NH2

F

14

[M+H]+

[M+H]+

[M+Na]+

[M+Na]+

Data from:-

Dr. María Ibáñez Martínez


5F-AB-PINACA single peak by GCMS

Internal standards


The challenge to SEWPROF is to move faster

Monitor market half life of new compounds TNM1/2 UK

Time from first detection to disappearance from the local market

Characterise new compound

Minimum data set

* Pharmacology / Toxicology

* Dose

* Duration of action

Distribute standards

Access or guess human/bacterial metabolism

Access stability

Develop and validate analytical method

Implement


Documents

John Ramsey