John Bowers - 2013 UCSB Faculty Research Lecture

7/22/2019 John Bowers - 2013 UCSB Faculty Research Lecture

http://slidepdf.com/reader/full/john-bowers-2013-ucsb-faculty-research-lecture 1/87

9

4:97 Aigucty Tbsbirgf Cbgturb

Mnfl B. Dnwbrs, Horbgtnr, Olstotutb anr Blbr`y BaaogoblgyEivco Zrnabssnr na Lilntbgflncn`y

Xfb Zrnkosb na Wocognl Zfntnlogs



Pfit os socognl pfntnlogs>

Kieol`pfntnlogoltb`ritbhgorguotsnlWocognlusol`GKNWprngbsstbgflncn`yoliGKNWaid

4

Pfy os ot okpnrtilt>

Pfit os tfb auturb>

Pfit os tfb prndcbk>

Pfit os tfb bgnlnkog hrovbr>



Do` Hiti

7

• Oltbrlbt Rsbrs= 4 docconl (<4:% na Pnrch pnpucitonl)

• @nn`cb Wbirgf= Knrb tfil i docconl sbirgfbs hiocy

• _nuXudb ihhs 48 fnurs na vohbn bvbry kolutb, 9+ docconl vobws i hiy



Kndocb Hiti Xriaaog

8 Wnurgb= Lbtwnre Xriaaog Anrbgist ilh Ilicysos ‗ 4:97-4:90 dy Olanrkitonl @itbebbpbrs 4:97.

Xnhiy X d y t b s / k n

l t f



Xfb @rnwtf na Hiti Xrilskossonl

Eocpbr bt, ic., –Znwbr Xrblhs ol Gnkkulogitonl Lbtwnres,‛ M. Wbcbgtbh Xnpogs ol Yuiltuk Bcbgtrnlogs, Kirgf/Iproc 4:99

9::x

Hiti trilskottbh nvbr i aodbr nptog digednlb



Xfb @rnwtf na Xbcbgnkkulogitonl

Znwbr Gnlsukptonl

G. Cil`b bt ic., –Blbr`y Gnlsukptonl na Xbcbgnkkulogitonl Lbtwnres ilh Tbcitbh Okprnvbkblt Nptonls,‛ M. Wbcbgtbh Xnpogs olYuiltuk Bcbgtrnlogs, Kirgf/Iproc 4:99



Hiti Wbrvbrs

Wnurgb= Blbr`y Gnst, tfb Eby Gficcbl`b na Xnhiy‟s Hiti Gbltbrs, Kogfibc Znbss(Nrigcb) ilh Ti`fulitf N. Likdoir (FZ) 4:9:



Hiti Gbltbr Girdnl Anntprolt



Hiti Gbltbr Girdnl Anntprolt



I Hiti Gbltbr (Pirbfnusb Gnkputbr)

9:



Cnts na Gnncol` Xnwbrs

99



Cnts na gnncol` witbr …

94



Knhbrl Hiti Gbltbr

97

• 9:: KP pnwbr

• Kocconl na sbrvbrs• Xbls na tfnusilhs na aodbrs

Arnk Hnll Cbb (Aigbdnne)



Wbrvbrs

98

K c h h o f c o c



Knstcy gnllbgtbh tnhiy wotf bcbgtrogic

gidcbs wotfol i rige

92



Lnl-Wgicidcb Aodbr Oltbrgnllbgts ol i Hiti Gbltbr

91



I @cndic Nptogic Lbtwnre

–Anccnw tfb sul‛ hiti gbltbr stritb`y=@cndic cnih dicilgol`. Rsb gfbipbr bcbgtrogoty it lo`ft.



96

Pnrchwohb Aodbr Nptog Gnkkulogitonl



Kirgnlo

Xrils-Itcil;g

Abssblhbl

Xrils-Itcil;g

L_-ZirosAorstXrils-Itcil;g

Lbwfivbl-Iznrbs

EbyPbst-Fivili

XIX-2

XIX-7XIX-9

XIX-6

XIX-9:XIX-99

XIX-?

XIX-94/97

PHKtbrrbstroic

961:966: 9?:: 9?4: 9?8: 9?1: 9?6: 4::: 4:4: 4:8:

_bir

B

l b r ` y / D o t / 9 :

: : - e k

( M )

9:

9:

9:

9:

9:

9:

1

7

-7

-1

-?

-94

9::

Tbhugtonl ol blbr`y tn trilspnrt i dot

igrnss tfb ngbil

9:: Kocconl

Iatbr Xugebr 4:99



Olvbltonl na Knrsb Gnhb

Pfbrb hoh ot icc dbòl>967? Poccoik Knrsb= Olvbltonl na Knrsb Gnhb ilh tfb

tbcb`ripf. Xfb aorst kbssi`b= "Pfit fitf @nh

wrnu`ft!''

4:



Xfb Aorst Xrilsitciltog Gidcb

967? @osdnrlb ilh Aobch

Xfb aorst twn ittbkpts aiocbh… Nl 91 Iuùst,9626 i tbcb`rik na

gnl`ritucitonls arnk Yubbl Qogtnroi

tn RW Zrbsohblt Mikbs Dugfilil

49 Iìkbklnl ilh Loi`ri ciyol` gidcb



Porbcbss Xbcb`ripfy

• 9?:4 Kirgnlo Olvbltonl na worbcbss tbcb`ripfy (rihon)• Porbcbss trilskossonl igrnss tfb Itciltog

• 9?94 Pnrh na tfb Xotilog soleol` sblt tn sfnrb. Kirgnlo fih dbblsgfbhucbh nl tfit trop, dut fih cbat nl tfb Cusotiloi tfrbb hiys bircobr. 44




igrnss tfb ngbil

Kirgnlo

Xrils-Itcil;g

Abssblhbl

Xrils-Itcil;g


Lbwfivbl-Iznrbs

Porbcbss

Xbcb`ripfy

961: 966: 9?:: 9?4: 9?8: 9?1: 9?6: 4::: 4:4: 4:8:

_bir

B l b r ` y / D o t / 9 :

: : - e k

( M )

9:

9:

9:

9:

9:

9:

1

7

-7

-1

-?

-94

9::



Xfb Olvbltonl na tfb Xbcbpfnlb

• 9601 Dbcc spbies tfb aiknuswnrhs= "Kr. Pitsnl -- gnkb

fbrb -- O wilt tn sbb ynu.‛

48 Icbxilhbr @rifik Dbcc



Kuctopcbxol` os Grugoic

Lbw _nre Goty 9?:7

Xokb kuctopcbxol` wis olvbltbh ol 9?9: dy @bnr`b N. Wquobr. Ot

iccnwbh kuctopcb tbcbpfnlb giccs tn db trilskottbh nvbr nlb worb.



Gnix Gidcb

41

9?79 Ccnyh Bspblsgfobh ilh Fbrkil I. Iaabc olvbltbh gnixoic gidcb

Gidcb wotf 44 gnixoic gidcbs tfit gil girry ?:,::: tbcbpfnlb giccs



Aorst Xrilsitciltog Xbcbpfnlb Gidcb

• XIX-9 9?21 IXX Dbcc Cids ilh Drotosf Znst Naaogb

T h to o t t t dot




igrnss tfb ngbil

Kirgnlo

Xrils-Itcil;g

Abssblhbl

Xrils-Itcil;g


Lbwfivbl-Iznrbs

XIX-7976gfillbcsXIX-971gfillbcs

~4:%p.i.okprnvbkblt

Porbcbss

Xbcb`ripfy

Gnix

961: 966: 9?:: 9?4: 9?8: 9?1: 9?6: 4::: 4:4: 4:8:

_bir

B l b r ` y / D o t / 9 : : : - e k

( M )

9:

9:

9:

9:

9:

9:

1

7

-7

-1

-?

-94

9::



Xrilsostnr

Mnfl Dirhbbl, Poccoik Wfngecby, Pictbr Drittiol

Xfb trilsostnr wis hbknlstritbh ol 9?80 ilh Wfngecby, Dirhbbl, Drittiol

rbgbovbh tfb Lndbc Zrozb ol 9?21. Xfos blidcbh sncoh stitb ikpcoaobrs.

T h to o t t t dot




igrnss tfb ngbil

Kirgnlo

Xrils-Itcil;g

Abssblhbl

Xrils-Itcil;g


Lbwfivbl-Iznrbs

XIX-7XIX-9

~4:%p.i.okprnvbkblt

Porbcbss

Xbcb`ripfy

Gnix

961: 966: 9?:: 9?4: 9?8: 9?1: 9?6: 4::: 4:4: 4:8:

_bir

B l b r ` y / D o t / 9 : : : - e k

( M )

9:

9:

9:

9:

9:

9:

1

7

-7

-1

-?

-94

9::

XIX-08:::gfillbcs

Kogrnwivb gidcb ilh kogrnwivb iltbllis



Kogrnwivb gidcb ilh kogrnwivb iltbllis

wbrb hnkolilt tfrnu`f tfb 9?1:s

79

1 gk hoikbtbr gorgucir

wivbùohbs wotf 8: tn 94:

@Fz anr 47:,::: vnogb

gorguots.



Olvbltonl na Aodbr Nptogs

74

Ol 9?11, Gfircbs Ein stuhobh nptogic cnssbs ol `ciss, sbt tfb `nicna 4: hD/ek ilh rbgbovbh tfb Lndbc Zrozb 4:9:

Tndbrt Kiubr, Hnlich Ebge, ilh Zbtbr Wgfuctz, arnk Gnrlol`puroaobh socogi ilh rbhugbh nptogic cnss tn 91 hD/ek ol 9?0:.

Ol 9628, Mnfl Xylhicc hbknlstritbh tn tfb Tnyic Wngobty tfit co`ft gnuchdb gnlhugtbh tfrnu`f i gurvbh strbik na witbr, prnvol` tfit i co`ft

so`lic gnuch db dblt.



Pfy Aodbr Nptogs>

77

• Cnss os cnw (:.4 hD/ek 922: lk G-dilh anr aodbr gnkpirbh

tn 9::: hD/ek anr gnix it 4: @Fz)• Gipigoty os cir`b (7::,::: @Fz anr aodbr gnkpirbh tn 4:

@Fz anr gnix)



Olvbltonl na Wbkognlhugtnr Cisbr

Lndbc Zrozb ol 4:::

• 9?14 Aorst Wbkognlhugtnr Cisbr

‗ Tndbrt L. Ficc it @blbricBcbgtrog

‗ Kirsficc Litfil it ODK

‗ KOX Colgncl Cidnritnry

• 9?14 Ernbkbr= Olvbltonl na

Hnudcb fbtbrnstrugturb cisbr 8::x



Aorst Gnkkbrgoic Aodbr Nptog Gidcb

Ol 9?00, tfb aorst nptogic tbcbpfnlb gnkkulogitonl systbk wis olsticcbh idnut 9.2kocbs ulhbr hnwltnwl Gfogi`n, ilh bigf nptogic aodbr girrobh tfb bquovicblt na

104 vnogb gfillbcs.





igrnss tfb ngbil

Kirgnlo

Xrils-Itcil;g

Abssblhbl

Xrils-Itcil;g


Lbwfivbl-Iznrbs

XIX-7XIX-9

XIX-68:,:::gfillbcs

~4:%p.i.okprnvbkblt

XIX-9:XIX-999.97@dps

XIX-?

Porbcbss

Xbcb`ripfy

Gnix

Nptogic + Tb`bl.

Nptogic + BHAI

PHK

961: 966: 9?:: 9?4: 9?8: 9?1: 9?6: 4::: 4:4: 4:8:

_bir

B l b r ` y / D o t / 9 : : : - e k

( M )

9:

9:

9:

9:

9:

9:

1

7

-7

-1

-?

-94

9::

XIX-08:::gfillbcs



•

Xfb brdouk hnpbh aodbr ikpcoaobr (BHAI) wis hbvbcnpbhdy Ziylb‟s `rnup it tfb Rlov. na Wnutfikptnl ol tfb citb

9?6:s. Xfos hbvogb ikpcoaobs co`ft so`lics ol il nptogic

aodbr lbtwnre.

70

Olvbltonl na tfb BHAI

• Xfos cbh tn XIX-94/97 npbritol` it 2 @dot/s(ipprnxokitbcy 7::,::: vnogb gorguots)



76

Pivbcbl`tf Hovosonl Kuctopcbxol`

PHK wis hbknlstritbh dy IX&X ol 9?06 ilh hbpcnybh ol 9?64 arnk Dnstnl tn

Pisfol`tnl usol` @iIcIs cisbrs it 642 ilh 602 lk, ilh il Ol@iIsZ CBH it97:: lk.

Lnt wohbcy usbh ultoc 9??4 iatbr tfb olvbltonl na tfb nptogic ikpcoaobr.





igrnss tfb ngbil

Kirgnlo

Xrils-Itcil;g

Abssblhbl

Xrils-Itcil;g


Fypbrloi9:Xdps

Lbwfivbl-Iznrbs

EbyPbst-Fivili XIX-7XIX-9

XIX-68:,:::gfillbcs

~4:%p.i.okprnvbkblt

XIX-9:XIX-999.97@dps

XIX-?

Porbcbss

Xbcb`ripfy

Gnix

Nptogic + Tb`bl.

Nptogic + BHAI

PHK

961: 966: 9?:: 9?4: 9?8: 9?1: 9?6: 4::: 4:4: 4:8:

_bir

B l b r ` y / D o t / 9 : : : - e k

( M )

9:

9:

9:

9:

9:

9:

1

7

-7

-1

-?

-94

9::

XIX-94/979:@dps

XIX-989.60Xdps

XIX-08:::gfillbcs





igrnss tfb ngbil

Kirgnlo

Xrils-Itcil;g

Abssblhbl

Xrils-Itcil;g

L_-Ziros

XIX-7XIX-9

XIX-68:,:::gfillbcsXIX-9:XIX-999.97@dps

Porbcbss

Xbcb`ripfy

Gnix

Nptogic + Tb`bl.

Nptogic + BHAI

PHK

961: 966: 9?:: 9?4: 9?8: 9?1: 9?6: 4::: 4:4: 4:8:

_bir

B l b r ` y / D o t / 9 : : : - e k

( M )

9:

9:

9:

9:

9:

9:

1

7

-7

-1

-?

-94

9::

Xrilsostnr

HnudcbFbtbrnstrugturb

Wbkognlhugtnr Cisbr

Xbcb`ripf

Xbcbpfnlb

Kuctopcbxol`Gnix

PHK

BHAI

Nptogic Aodbr





igrnss tfb ngbil

Kirgnlo

Xrils-Itcil;g

Abssblhbl

Xrils-Itcil;g

L_-Ziros

XIX-7XIX-9

XIX-68:,:::gfillbcsXIX-9:XIX-999.97@dps

Porbcbss

Xbcb`ripfy

Gnix

Nptogic + Tb`bl.

Nptogic + BHAI

PHK

961: 966: 9?:: 9?4: 9?8: 9?1: 9?6: 4::: 4:4: 4:8:

_bir

B l b r ` y / D o t / 9 : : : - e k

( M )

9:

9:

9:

9:

9:

9:

1

7

-7

-1

-?

-94

9::

Xrilsostnr

HnudcbFbtbrnstrugturb

Wbkognlhugtnr Cisbr

Xbcb`ripf

Xbcbpfnlb

Kuctopcbxol`Gnix

PHK

BHAI

Nptogic Aodbr

9:: Kocconl



Xrilskossonl Tbsbirgf rbgnrhs

9?61 9??: 9??8 9??6 4::4 4::1

9:

9::

9

9:

9::

G i p i

g o t y

n l

i

s o l ` c b

a o d b r

@ d / s

X

d / s

4:9:

Zcnt gnurtbsy na Z. Polzbr ilh Gfros Hnbrr

PHK stirtbh

Zncirozitonl HovosonlKuctopcbxol` stirtbh

Wpigb Hovosonl Kuctopcbxol`(WHK) stirtol`Zfisb hovbrsoty

stirtbh

9?00= 2: Kdot/s

7:2 Xdot/s

nl i sol`cb

aodbr (4:94)

1 KocconlOl 74 ybirs



87

Cnl` Fiuc=• 1 kocconl olgrbisb ol gipigoty ol 74 ybirs.• 9:: kocconl hbgrbisb ol blbr`y/dot ol 92: ybirs.

Pfit idnut swotgfol`>

Tnutbrs ilh Wwotgfbs=



Tnutbrs ilh Wwotgfbs=Znwbr ilh Znwbr Hblsoty irb Zrndcbks

• Bcbgtrogic Gnrb swotgfbs= <9:

eP/rige anr 421 9: @dot/sgfillbcs

88

• Znwbr hblsoty ol fo`f spbbh swotgfol` gfops itaulhikbltic cokots

• Wgicol` tn cir`br swotgfbs ilh fo`fbr dot ritbshoaaoguct.

• Znwbr prnpnrtonlic tn arbqublgy squirbh!

Cnw Znwbr



82

Cnw Znwbr7H KBKW Wwotgf Irgfotbgturb

Wocognl Aodbr Dcnge

768 Gnccokitbh Dbiks

Wocognl KBKW Korrnr Zcilb

768 Korrnrs

Bcbgtrnstitog Gnltrnc

Knvbs ol V & _

4H @ykdic Korrnr

Dnwbrs bt ic. Nptogic KBKs gnlabrblgb 4::?

Wocognl Zfntnlog oltb`ritonl os eby!

• Okpnssodcb tn duoch cir`b (<9:: pnrt) swotgfbs

wotfnut oltb`ritonl.

• Cir`b wiabr sozb bssbltoic.

• GKNW prngbss uloanrkoty bssbltoic (fol`bs).

9: lI x 9:: Q ; 9 kogrnP/gfillbc



Kily bcbgtrnlog sbrvbrs ilh swotgfbs rbquorb so`loaogilt pnwbr

(9 KP anr snkb rnutbrs)

<9:,:::x



80

NAG NXuF4 4:99

Xrihotonlic Irgfotbgturb

Bcbgtrogic

Bcbgtrogic

Bcbgtrogic

Nptogic



86

NAG NXuF4 4:99

Xrihotonlic Irgfotbgturb Bkbròl` Irgfotbgturb



8?Hil Xirhblt ZGX 4:97



2:Hil Xirhblt ZGX 4:97



29

Gfop tn Gfop9 ‗ 2: gk

Dnirh tn Dnirh

2: ‗ 9:: gk

9 tn 9:: k

Tige tnTige

:.9 ‗ 6: ek

Kbtrn & Cnl` Fiuc

Hbgrbisol` Hostilgbs↔

Docconls

Kocconls

Xfnusilhs

Q nc uk b s

Nptogic Gnppbr

Knvol` tn Oltbrgnllbgts

OltbcNptogicZrnhugts

Hrovb nptogic tn fo`fvncukbs ilh cnw gnsts

Pf t d t O t t >



Pfit idnut Oltbrgnllbgts>

• Ln so`loaogilt oltb`ritonl (typogiccy 4 nr 7 hbvogbs/ZOG)

• Gnst os fo`f

• Wozb os cir`b

• Znwbr os cir`b (9 P/@dps)

24

9?4 wivbcbl`tf

trilskossonl systbk

Pf t O t t >



27

9:: @d/s Xrilskot

9:: @d/s Tbgbovb

Pfy lnt Oltb`ritb>

9:: @d/sTbgbovb

9:: @d/sXrilskot

T. Liìrimil, Olaolbri BGNG 4::0

OlaolbriWncutonl

Pf Woco Zf t o >



Pfy Wocognl Zfntnlogs>

• Oltb`ritb pfntnlogs wotf bcbgtrnlogs

‗ Wikb wiabr

‗ Dukp dnlhol` na socognl ZOG wotf socognl OG

• Wikb gnbaaogoblt na tfbrkic bxpilsonl

‗ 7H stigeol`

• Tbhugb gnst dy `nol` tn cir`br hoikbtbr wiabrs

‗ OlZ cokotbh dy wiabr drbiei`b tn 9:: kk hoikbtbr

• Tbhugb gnst dy sfirol` QCWO aigocoty wotf bcbgtrnlogs

• Okprnvb yobch dy tieol` ihvilti`b na socognl prngbss

hbvbcnpkblt

• Qncukb hrovbr= Wncvb OG oltbrgnllbgt dnttcblbge (arnk 8Xdps tn 9 Zdps). Nptogic trilskottbrs/rbgbovbrs nl

prngbssnrs, kbknrobs, swotgfbs. 28

Grnss-sbgtonlic vobw na il ODK WocognlLilnpfntnlogs gfop gnkdolol` nptogic ilh

bcbgtrogic gorguotsQcisnv bt ic. OBHK pnsthbihcolb

Drolòl` Wo Kiluaigturol` tn tfb Cisbr



Drolòl` Wo Kiluaigturol` tn tfb Cisbr

Cisbrs Wo Kiluaigturol`

Qbry fo`fdilhwohtf

Cnl` hostilgbs

Okkuloty tn

bcbgtrogic lnosb

Fo`f vncukb,cnw gnst

Fo`fcyoltb`ritbh

Wgicidocoty

Gnurtbsy= Tittlbr (Oltbc)

_birnaZrnhugtonl 9??2 9??6 4::9 4::8 4::0 4:9: 4:97 4:91

HTIK9/4Zotgf(lk) 40: 9?: 97: ?: 12 87 74 44

PiabrWozb(kk) 92: 4:: 4:: 4:: 7:: 7:: 7:: 82:

OlZZfntnlog

Oltb`ritbhgorguots

WocognlZfntnlog

Oltb`ritbhgorguots

Wox @blbritonls

Wocognl Zfntnlogs os lntidnut Wocognl.

Ot os idnut usol` GKNWprngbssol` tn kieb

pfntnlog oltb`ritbhgorguots wotf fo`f quicoty

ilh cnw gnst.

Fydroh Wocognl Zfntnlogs



Fydroh Wocognl Zfntnlogs

Wocognl rod wivbùohb nlWNO wiabr

OOO-Q igtovbrbònl

‗ Nptogic ìol arnk OOO-Q Kitbroic ‗ Baaogoblt gnupcol` tn socognl pissovb pfntnlog hbvogbs

‗ Ln dnlhol` ico`lkblt lbgbssiry= suotidcb anr fo`f vncukb GKNW

‗ Icc dige blh prngbssol` cnw tbkpbriturb (372: G)

21

0 cisbrs npbritol` g.w.

sokuctilbnuscy Icbx Ail`s Xfbsos

Wocognl

Horbgt @ip OOO-Q

F d oh Woco Fo t Gf c



Fydroh Wocognl Fostnry Gfrnlncn`y• 4::1 Aorst fydroh socognl cisbr= Icbx Ail` bt ic.

• 4::0 Aorst gw cisbr pbranrkilgb= Icbx Ail` bt ic.

• 4::0 Aorst fydroh socognl ikpcoaobr= Fyulhio Zire bt ic.

• 4::0 Aorst fydroh socognl pfntnhbtbgtnr= Fyulhio Zire bt ic.

• 4::0 Aorst fydroh socognl rol` cisbr= Icbx Ail` bt ic.

• 4::0 Aorst fydroh socognl knhb cngebh cisbr= Droil Engf bt ic.

• 4::6 Aorst fydroh socognl bcbgtrnidsnrptonl knhucitnr _. Eun bt ic.

• 4::6 Aorst fydroh socognl hostrodutbh abbhdige (HAD) cisbr= Icbx Ail` bt ic.

• 4::6 Aorst fydroh socognl Kigf ]bflhbr knhucitnr F. P. Gfbl bt ic.

• 4::6 Aorst nptogic duaabr= Zire bt ic.

• 4::? Aorst 92: kk dnlhol`= Coil` bt ic.

• 4::? Aorst 4:: kk dnlhol`= Oltbc, Iurronl bt ic.

• 4:9: Aorst tropcbxbr (Cisbr+4 ZHs+4 wivbcbl`tf sbcbgtovb gnkdolbrs) Gfil`

• 4:99 Aorst fydroh socognl PHK irriy Miol bt ic.

• 4:99 Aorst nptogic dbik sgillbr= Dibts (@fblt) bt ic.

• 4:97 Aorst oltb`ritonl na fydroh socognl tbgflncn`y wotf RCCP tbgflncn`y Zobcs bt ic.

•

4:97 Aorst gn-prngbssol` na hitignk ilh tbcbgnk ZOGs= Droil Engf bt ic.• 4:97 Aorst uiltuk hnt cisbrs= Icil Cou bt ic.

20

F d oh Woco T h Z a



Fydroh Wocognl Tbgnrh Zbranrkilgb• 4:97 Lirrnwbst HAD colbwohtf= 96 eFz _irov bt ic. (Gictbgf)

• 4:94 Fo`fbst gw pnwbr= 82 kP Icbx Ail` bt ic. (Iurronl)

• 4:99 Cnwbst wivbùohb cnss nl socognl= :.:8 hD/k Mirbh Diutbrs bt ic.

• 4:94 Fo`fbst cbvbc na oltb`ritonl= 18 hbvogbs Mnl Hnycblh bt ic.

• 4:94 Aorst stuhy na rbcoidocoty= 8:,::: fnurs it 0:G Wrolovisil bt ic.

• 4:94 Fo`fbst cisbr yobch= ??% Wrolovisil bt ic.

• 4:94 Aistbst Wo knhucitnr= 08 @Fz Xil` bt ic.

•

4:97 Fo`fbst rbgbovbr dilhwohtf= 8:: @dot/s Zobcs bt ic.• 4:97 Cir`bst cisbr irriy dilhwohtf= < 4:: lk Miol bt ic.

• 4:97 Cir`bst CBH dilhwohtf= <4:: lk Hb@rnntb bt ic.

• 4:97 Fo`fbst tbkpbriturb= 94:G Icil Cou bt ic.

26 _. Eun, bt ic., NB 91(97), ??71 (4::6) _. Xil`, bt ic., NB 9?(0), 2699(4:99)

cukpbh= ~4: @FzXP= ~84 @Fz

Wb`kbltbh＝ 08@Fz

Xil` bt ic. NAG4:94 Znsthbihcolb Zipbr

Hbknlstritbh f droh socognl hb ogbs



Hbknlstritbh fydroh socognl hbvogbs

HAD

rol`

AZ, rol`, HAD, ilh HDT cisbrs(Ail`, OBBB ZXC, 4: , 4::6 )

HDT

K]K BIK

08-@Fz BIK, 40-@Fz K]O knhucitnrs(Gfbl, NWI NB , 9?, 4:995 Xil`, NWI NB , 4:, 4:94)

Kogrnrol`cisbr

Kogrnrol` rbsnlitnr cisbr (Coil`, @AZ , 4::?)

Wcohb 2?

IKZhbtbgtnr

<4: @Fz pfntnhbtbgtnr (Airicco, NWI NB , 4:, 4:94)

9? hD/kk ikpcoaobr

(Eurgzvboc, WZOB ZP, 4:99)

Fydroh Wocognl Cisbr Tbsbirgf



y

Zfntnlog Oltb`ritonl



Zfntnlog Oltb`ritonl

Kbolt Wkot Hiti

Fbge MWXYB (4:97)

Oltbc 2: @d/s PHK Cole



Oltbc 2: @d/s PHK Cole

14

I Ichuoln bt ic, OZT 4:9:

Mil 4:97 NGZ ‗ Aigbdnne illnulgbkblt



Illnulgbh it Aigbdnne‟s Npbl Gnkputb Wukkot9. Oltbc os wnreol` wotf Aigbdnne ilh Yuilti tn hbaolb i lbw gciss na sbrvbr

irgfotbgturbs

4. Aorst irgfotbgturb os hosi``rbìtonl7. Oltbc fis sikpcbh ot‟s 9::@ pfntnlog knhucbs

Arile ArilenwseyAD QZ T&H

Mustol TittlbrOltbc GXN

Ilhy DbgftncsfbokIrosti= Anulhbr ilh GBN

Wul= Anulhbr ilh GXN

Wbpt. 4:97R o Woco Zf t o a Ho to



Rsol` Wocognl Zfntnlogs anr Hosi``rbìtonl

Kbzzilolb Gfnogbs

Oltbc Btfbrlbt gfop ilhWocognl Zfntnlogs

Nptogic ZGOb voiWocognl Zfntnlogs

Oltbc® Vbnl ®prngbssnr disbh triy

Kbzzilolb Aodbr

Oltbc® ItnkXK

Kogrn-sbrvbr

triy

Acbxodocoty & XGN ìols dy up`rihol` gnkpnlblts nlcy wfbllbbhbh

Zfntnlogs ol tfb Tige



12

Nptogic Tige

Zfntnlogs ol tfb Tige

GZR Kbk HHT

Wbrvbr

GZR Kbk HHT

Wbrvbr

GZR Kbk

Vbnl=ZGObItnk=Blbt

HHT Wbrvbr

VbnlilhItnkAidrog

Gnkputb

FHHs ZGOb GZR WWHs

GnkputbLbtwnre

GZR Kbk HHT

Wbrvbr

GZR Kbk HHT

Wbrvbr

GZR Kbk HHT

Wbrvbr

W o Z f

W o Z f

W o Z f

T T G

T T G

T T G

XNT Wwotgf hostrodutbholtn Wbrvbrs

9 : : @ c o l e s

Irgfotbgturb naabrs acbxodcb sncutonls ilh kuctopcb Qicub Zrnpnsotonls

TbkntbWtnri`b

O / N Ippcoilgb

XnWpolbWwotgfbs

Lbtwnre

Wtnri`b

Gnkputb

Wwotgf IWOG

GZR

LOG WWH LOG WWH

Wbrvbr

Lbtwnre & Wtnri`b knvboltn XNT Wwotgf

WoZf WoZf

GZR Kbk HHT

GZR Kbk HHT

GZR Kbk HHT

W o Z f

ZGOb

ZGOb

ZGOb

Wbrvbr

Wbrvbr

Wupbrgnkputol`=



FZ pfntnlogs tbgflncnòbs

T x

X x

T x T x T x T x T x T x T x

Nptogic dus

Lnw 9 _bir 7 _birs 2 _birs 0 _birs9:

_birs

Igtovb gidcbFydroh kogrnrol` cisbr Wocognl ZOG

Nl-gfop

oltbrgnllbgt

Wol`cb wivbcbl`tf GPHK HPHK

9:: pM/dot <.9 pM/dot

Iurronl ZOG Oltb`ritonl



`

<71 @Fz, :.6 I/P

Zfntnhbtbgtnrs

Knhucitnrs= 47 @Fz, <92 hD BT, 9.7 Qpo

: 2 9: 92 4: 42 7: 72 8:-1

-8

-4

:

Arbqublgy (@Fz)

B / N T

b s p n l s b ( h D )

Xbcbgnk Xulidcb CisbrsHitignk ulgnncbh PHK cisbr irriys

Droil Engf bt ic., NAG Znsthbihcolb 4:97

Wbpiritb wiabr= 82 kP GP Cisbrs

ODK Iurronl Fydroh Wocognl 1: @dps Tbgbovbr= GCBN Znsthbihcolb 4:97





Xfb Zrnkosb na Wocognl Zfntnlogs

1?

Zitf tn Rctricnw Cnss Pivbùohbs



Diutbrs bt ic. Nptogs Bxprbss (4:99)

Aodbrs fivb cnw cnss= :.:::4 hD/k (:.4 hD/ek)

Nptogic wivbùohbs nl OlZ, @iIs, Wo fivb fo`f cnss= 7: hD/ek

Fnw gil wb `bt aodbr cnssbs nl gfops>

Potf Dcukbltfic

Zitf tn Rctricnw Cnss Pivbùohbs



Diutbrs bt ic. Nptogs Bxprbss (4:99)

Potf Dcukbltfic

-8:

-7:

-4:

-9:

:

9:

9240 9279 9272 927? 9287 9280 9229 9222

Pivbcbl`tf (lk)

Z n w b r ( h D k )

AWT;42.7lk

919 94 7 8 2 1 0 6 ? 9: 99 9497 98 92

socognl sudstritb

tfbrkic WoN4

WoN4

Wo7L8

tfbrkic WoN4

Fo`f Y Tbsnlitnrs (6:Koccon

GKNW Oltb`ritonl ol Zfntnlog OG



WNI HBX

WNO

Pivbùohbs

Fydroh Wocognl ZOG arnk Iurronl

q –Wkirt Zfntnlogs‛ ̱ Oltb`ritbh bcbgtrnlog w/ pfntnlog OGs

q Ivnoh hrovol` 2:ί tbrkolitonlsq Wbca-gicodritonl

q Igtovb abbhdige gnltrnc

`(wotf Xfbnìrimil)

GKNW Oltb`ritonl ol Zfntnlog OG



`(wotf Xfbnìrimil)

q –Wkirt Zfntnlogs‛ ̱ Oltb`ritbh bcbgtrnlog w/ pfntnlog OGs

q Ivnoh hrovol` 2:ί tbrkolitonlsq Wbca-gicodritonl

q Igtovb abbhdige gnltrnc

ZOG

GKNW

Oltbrgnllbgts

Gfbl bt ic. NAG 4:97

TNRXBT ON ZNPBT WGICOL@



ON pnwbr ol witts anr 18, 9:: ilh 988 pnrt swotgfbs

TNRXBT ON ZNPBT WGICOL@

• Issukbs bigf ̀ blbritonl wocc rbquorb i hnudcol` na pnrt spbbh tn kitgf okprnvbkbltsol prngbssnr pbranrkilgb

• Xntic hbvogb pnwbr kust db cbss tfil 97:P anr lnrkic anrgbh ior gnncol` wotf fbitsole,4::P pnssodcb wotf spbgoic gnncol`. Issukb kix pnwbr duh`bt na 2:% (12P) anr ON.

@blbritonl Znrt DP(@dps) ON typb aM/dot 18 9:: 988

82lk 6: Bcbgtrnlog 0::: 72.6P 21.:P 6:.1P

6: Nptogic 829 4.7P 7.1P 2.4P

72lk 91: Bcbgtrnlog 2:86 29.0P 6:.6P 991.7P

91: Nptogic 468 4.?P 8.2P 1.2P

44lk 74: Bcbgtrnlog 8:8? 64.?P 94?.1P 961.1P

74: Nptogic 9?9 7.?P 1.9P 6.6P

Nptogic ON nl GKNW



p

Lbtwnre nl i Gfop=N to c O t t



Nptogic Oltbrgnllbgts

• 7H ciybr stigeol` wocc db

prbvicblt ol tfb 44lktokbarikb

• Oltri-gfop nptogs gil tieb

ihvilti`b na tfos

tbgflncn`y

• Zfntnlogs ciybr (wotf

suppnrtol` bcbgtrogic

gorguots) knrb bisocy

oltb`ritbh wotf fo`f

pbranrkilgb cnòg ilh

kbknry ciybrs

• Ciybrs gil db sbpiritbcy

nptokozbh anr pbranrkilgb

ilh yobch

N p t o g

i c O / N

Cnòg Zcilb

N a a - g f

o p n

p t o g

i c

s o `

l i

c s

N l

- g f o p

n p t o g i

c t r i

a a o g

Zfntnlog ZcilbKbknry Zcilb

Eisf, –Zfntnlogs ol Wupbrgnkputol`=

tfb Tnih tn Bxisgicb,‛ OZLTI, 4::?

Fo`f Zbranrkilgb Gnkputol`



Znwbr Gnlsukptonl

Tnihrullbr (ODK)

ODK Dcub

@blb/Z ODK DcihbGbltbr

OYZIGB gcustbr

ODK DcihbGbltbr

Miùir

(Griy)

Litonlic WupbrGnkputbr

Gbltbr, Xoilmol, Gfoli

Litonlic Istrnlnkogic

Ndsbrvitnry, Mipil

G n k p u t i t o n l i c X f r n u ` f p u t

ODK Dcub

@blb/Z

9::

@ACNZW

9

XACNZW

9:

XACNZW

9::

XACNZW

9 Zbti-

ACNZW

9: Zbti-

ACNZW

9 eP9: eP9:: eP9 KP9: KP

Filby bt ic, NAG 4:9:, pipbr NKQ4

9 @ACNZW/P

Fo`f Zbranrkilgb Gnkputol`

Filby NAG (4:99)

Fo`f Zbranrkilgb Gnkputol`=Oltbrgnllbgt Cokots



Znwbr Gnlsukptonl

G n k p u t i t o n l i c X f r n u ` f p u t

9 eP9: eP9:: eP9 KP9: KP

9::

@ACNZW

9

XACNZW

9:

XACNZW

9::

XACNZW

9 Zbti-

ACNZW

9: Zbti-

ACNZW

Issukol`=

• 8 pM/d gfop O/N cole pnwbr (anr 9:-9:: gk coles)

• 4:: P/gfop wotf 8: P iccngitbh tn O/N

• kioltiolol` ~.2 Dps/ACNZW O/N

ê Zbranrkilgb dirrobr it ~9: @ACNZW/P cokot

Filby bt ic, NAG 4:9:, pipbr NKQ4

–Zbti-ACNZW ol

i rige‛

Zbranrkilgb blidcbh dy i ~9: XACNZW kily-gnrb

gfop wotf oltb`ritbh gfop O/N it ~.8 pM/d=

~9:: @ACNZW/P

Oltbrgnllbgt Cokots

Filby NAG (4:99)

Iviocidcb blbr`y anr oltbrgnllbgts



Iviocidcb blbr`y anr oltbrgnllbgts

OBBB Zfntnlogs Gnlabrblgb, Wbpt. ?, 4:97Hivoh Koccbr

Kogrnrol`

Cisbrs

Cnwbr tfrbsfnch cisbrs

Fo`fbr scnpb baaogoblgyHo Coil`Gfnl` ]fil`

Icil Cou

Yuiltuk Hnt Cisbrs nl WoIcil Cou ilh Irt @nssirh



Icil Cou ilh Irt @nssirh

• Wtrilseo Eristilnv `rnwtf

• Fo`f gw tbkpbriturb (992G)

• Fo`f gw pnwbr (1: kP)

6:

Nsgoccitnrs



Nsgoccitnrs

• Xfb quobtbst nsgoccitnrs irb lnw nptogic (LOWX)

69

Rctri-stidcb GP Cisbr Abktnsbgnlh Cisbr Gnkd

+

Nsgoccitnrs



Nsgoccitnrs

• Xfb quobtbst nsgoccitnrs irb lnw nptogic (LOWX)

• Oltb`ritb nl i gfop!

• Oltb`ritbh knhb cngebh cisbrs (Wuhfi Wrolovisil,

Koeb Hivblpnrt)

•

Fo`f Y rbsnlitnrs (Hiryc Wpblgbr) (?: kocconl)

64

Zigei`bh RCCP Tol` Fbtbrn`blbnus ZOGDisbh Knhb-cngebh Cisbr

Wpbgtrnsgnpy-nl-gfop



Xfbnìrimil, Kbolfirt, Knsenvots

Idsnrp;nlspbgtrnsgnpy

Drnihdilh prndb

Drnihdilh Aoctbr prndb

Acunrbsgblgbspbgtrnsgnpy

Tikilspbgtrnsgnpy

H

spbgtrn

kbtbrH

H

Cisbr prndb

H

spbgtrn

kbtbrH

H

prndb

H

spbgtrn

kbtbrH

H

AoctbrCisbr

HbtbgtnrCisbr prndb

H

87Gnurtbsy=Dibts

Mirbh Fuckb

Wo-disbh Tikil Wpbgtrnkbtbr nl i Gfop



G. H. Kbolfirt, K. Knsenvots & M. Dnwbrs

@is sblsol`= N4, GN4, LN, F4W, GN, ilh L4N

Nptogic gnfbrblgb tnkn`ripfy



Nptogic gnfbrblgb tnkn`ripfy

71

stritukgnrlbuk voidcbbpohbrkos pipocciryhbrkos rbtogucirhbrkos

@._urtsbvbrbticGnurtbsy=Dibts

Ilhrbis Hb`rnntb

Oltb`ritb nl i gfop

Igelnwcbh`bkblts



`

RGWD=

Anrkbr stuhblts ilh pnsthngs= Icbx Ail`, Mirbh Diutbrs, Fuo Pbl Gfbl, Hinxol Hio, Mnl

Hnycblh, Kirtoml Fbge, Woh Miol, @bzi Eurzvboc, Droil Engf, Ho Coil`, Fyulhio Zire, KnccyZobcs, Zincn Zoltus, Kitt Wysie, _nl`dn Xil`, Misnl Xobl

Zrbsblt stuhblts= Mnge Dnvol`tnl, Koeb Hivblpnrt, Mirbh Fuckb, Icil Cou, Mnl Zbtbrs, Hiryc

Wpblgbr, Icbx Wpntt, Brog Wtiltnl, Wuhfi Wrolovisil, Gfnl` ]fil`

Gnccbiùbs= Tnh Icabrlbss, Hivb Iustnl, Hil Dcukbltfic, Cirry Gnchrbl, Lihor Hi`co, Wtbvb

Hbldiirs, Irt @nssirh, Fbrd Ernbkbr, Gfros Zickstrnk, Kire Tnhwbcc, Ihbc Wicbf, Cueb

Xfbnìrimil Oltbc = Togfirh Mnlbs, _okol Eil`, Kiron Ziloggoi, Kitt Wysie

Iurronl= Icbx Ail`, @rb` Aosf, Tnd @uzznl, Brog Ficc, Droil Engf, Broe Lnrdbr`, Ililh

Tikiswiky, Mnfl Tntf, Hil Wpirigol

Fbwcbtt Zigeirh= Ho Coil`, @bzi Eurzvboc, Tiy Dbiusncboc

Gcbilrnnk, KDB, KNGQH stiaa

Ky Aikocy= Irobc, Brog, Wtbvb, Gfros ilh Cibtotoi

61

Wukkiry



Wu i y

• GKNW gnkpitodcb socognl pfntnlogs gnkdolbs twn

`rbit olvbltonls=

‗ Xfb trilsostnr kogrnprngbssnr

‗ Xfb cisbr nptogic gnkkulogitonls

ilh blidcb <9::x cnwbr pnwbr ilh cnwbr pnwbr hblsoty.

• Wocognl pfntnlogs kiebs sblsb anr fo`f vncukb

kirebts coeb hiti gbltbrs, supbrgnkputbrs,

donsblsnrs, ilh tbcbgnkkulogitonls ilh anr fo`fcyoltb`ritbh, fo`f pbranrkilgb kirebts coeb cnw

pfisb lnosb nsgoccitnrs, `yrnsgnpbs, sblsnrs.

Documents

John Bowers - 2013 UCSB Faculty Research Lecture