JEOPARDY WEILL CORNELL MEDICAL COLLEGE - QATAR This costimulator is expressed by professional APCs including B cells, dendritic cells, and macrophages

JEOPARDYJEOPARDY

WEILL CORNELL MEDICAL COLLEGE - QATAR

This costimulator is expressed by professional APCs including B cells,

dendritic cells, and macrophages and binds to molecules on T cells called

CD28.

This costimulator is expressed by professional APCs including B cells,

dendritic cells, and macrophages and binds to molecules on T cells called

CD28.

What is B7 OR B7.1 or B7.2?

What is B7 OR B7.1 or B7.2?


These cells regulate the infiltration of leukocytes into

inflammatoryreactions.

These cells regulate the infiltration of leukocytes into

inflammatoryreactions.

What are venular endothelial cells?What are venular endothelial cells?


This complement component can mimic immediate

hypersensitivity reactions bydirectly causing mast cell

degranulation.

This complement component can mimic immediate

hypersensitivity reactions bydirectly causing mast cell

degranulation.

What is C5a?What is C5a?


This immunosuppressive drug inhibits transcription of the IL-2

gene.

This immunosuppressive drug inhibits transcription of the IL-2

gene.

What is cyclosporin A?



To avoid hypeacute rejection of grafts, efforts must be made to

ensure thatdonor and recipient match with

respect to these antigens.

To avoid hypeacute rejection of grafts, efforts must be made to

ensure thatdonor and recipient match with

respect to these antigens.

What are the ABO blood group antigens?

What are the ABO blood group antigens?


This rare renal complication is caused by human immune

complex disease andfollows infection with a gram-

positive organism.

This rare renal complication is caused by human immune

complex disease andfollows infection with a gram-

positive organism.

What is post -streptococcal glomerulonephritis?

What is post -streptococcal glomerulonephritis?


Affinity maturation in B cells mainly occurs in these lymphoid

structures.

Affinity maturation in B cells mainly occurs in these lymphoid

structures.

What are germinal centers?What are germinal centers?


The migration of lymphocytes into secondary lymphoid organs

occurs throughthese.

The migration of lymphocytes into secondary lymphoid organs

occurs throughthese.

What are high endothelial venules OR What are HEV?What are high endothelial venules OR What are HEV?


Centrocytes binding antigen and either complement or CD23 on

foliculardendritic cells are induced to express

this surface determinant to ensuretheir survival.

Centrocytes binding antigen and either complement or CD23 on

foliculardendritic cells are induced to express

this surface determinant to ensuretheir survival.

What is BCL-2?What is BCL-2?


The distribution of variable residues in immunoglobulin that

yieldsvariability can be measured using this famous plotting

method.

The distribution of variable residues in immunoglobulin that

yieldsvariability can be measured using this famous plotting

method.

What is Wu and Kabot?What is Wu and Kabot?


This type of immunity is present at birth and does not exhibit

specificityfor a foreign antigen.

This type of immunity is present at birth and does not exhibit

specificityfor a foreign antigen.

What is innate immunity ?

What is innate immunity ?


These low molecular weight compounds are not

immunogenic by themselves butcan become immunogenic if they are coupled to a higher

molecular weightcompound.

These low molecular weight compounds are not

immunogenic by themselves butcan become immunogenic if they are coupled to a higher

molecular weightcompound.

What are haptens?What are haptens?


A secondary, anamnestic immune response occurs more

rapidly than a primaryimmune response because of the presence of these cells.

A secondary, anamnestic immune response occurs more

rapidly than a primaryimmune response because of the presence of these cells.

What are memory cells ?

What are memory cells ?


This process refers to the coating of antigen by antibody

or complement tofacilitate phagocytosis.

This process refers to the coating of antigen by antibody

or complement tofacilitate phagocytosis.

What is opsonization?

What is opsonization?


The classical and alternate pathways of complement

converge on whichcomponent of complement.

The classical and alternate pathways of complement

converge on whichcomponent of complement.

What is C3?What is C3?


This immunodeficiency is associated with the failure of B

cells to mature.

This immunodeficiency is associated with the failure of B

cells to mature.

What is Bruton's agammaglobulinemia or X-

linked agammaglobulinemia?

What is Bruton's agammaglobulinemia or X-

linked agammaglobulinemia?


This molecule consist of an a chain non covalently associated

to B2microglobulin.

This molecule consist of an a chain non covalently associated

to B2microglobulin.

What is Class I MHC(major histocompatibility

complex)?

What is Class I MHC(major histocompatibility

complex)?


These cells are said to be restricted by MHC class I

molecules.

These cells are said to be restricted by MHC class I

molecules.

What are CD8 T cells?What are CD8 T cells?


These are the major cytokines produced by CD4 TH2 cells.

These are the major cytokines produced by CD4 TH2 cells.

What are IL-4, IL-5, IL-10 and IL-13

(Interleukin 4, 5,10, and 13)?

What are IL-4, IL-5, IL-10 and IL-13

(Interleukin 4, 5,10, and 13)?


A 9 month old baby was vaccinated against smallpox with attenuated smallpox virus. He developed a

progressive necrotic lesion of the skin, muscles, and subcutaneous tissue at

the site of inoculation. A deficiency of these

cells might account for this reaction.

A 9 month old baby was vaccinated against smallpox with attenuated smallpox virus. He developed a

progressive necrotic lesion of the skin, muscles, and subcutaneous tissue at

the site of inoculation. A deficiency of these

cells might account for this reaction.

What are T cells?What are T cells?


This type of hypersensitivity can lead to the development of

granulomas.

This type of hypersensitivity can lead to the development of

granulomas.

What is delayed type hypersensitivity (or

hypersensitivity type IV)?

What is delayed type hypersensitivity (or

hypersensitivity type IV)?


This disease is characterized by IgM antibodies present in

synovial fluidswhich have specificity for the heavy chain of IgG antibodies.

This disease is characterized by IgM antibodies present in

synovial fluidswhich have specificity for the heavy chain of IgG antibodies.

What is Rhematoid Arthritis?

What is Rhematoid Arthritis?


The following may result when a T cell recognizes an antigen in

the absenceof co-stimulation.

The following may result when a T cell recognizes an antigen in

the absenceof co-stimulation.

What is T cell anergy ?

What is T cell anergy ?


This is the site of somatic mutation and immunoglobulin

heavy chain classswitching.

This is the site of somatic mutation and immunoglobulin

heavy chain classswitching.

What is the germinal center ?

What is the germinal center ?


Receptors for the C1 component of complement are found on

these two classesof immunoglobulin.

Receptors for the C1 component of complement are found on

these two classesof immunoglobulin.

What are IgM and IgG?

What are IgM and IgG?


This is the predominant isotype of an antibody produced in a

primaryimmunization.

This is the predominant isotype of an antibody produced in a

primaryimmunization.

What is IgM ?What is IgM ?


Alternative RNA splicing enables a B cell to co-express these two

antibodies on a B cell simultaneously.

Alternative RNA splicing enables a B cell to co-express these two

antibodies on a B cell simultaneously.

What are IgM and IgD?

What are IgM and IgD?


This assay measures the clumping together of an

antibody with a particulateantigen.

This assay measures the clumping together of an

antibody with a particulateantigen.

What is an agglutination

reaction?

What is an agglutination

reaction?WEILL CORNELL MEDICAL COLLEGE - QATAR

A solid phase immunoassay which is commonly used in

clinical laboratoriesto detect the presence of

antibodies to gp120 in a serum sample.

A solid phase immunoassay which is commonly used in

clinical laboratoriesto detect the presence of

antibodies to gp120 in a serum sample.

What is an ELISA?What is an ELISA?


These molecules generally present exogenously derived

peptides frombacterial antigens to CD4 T cells.

These molecules generally present exogenously derived

peptides frombacterial antigens to CD4 T cells.

What are Class II MHC (major histocompatibility )

molecules?

What are Class II MHC (major histocompatibility )

molecules?WEILL CORNELL MEDICAL COLLEGE - QATAR

This autoimmune disease is mediated by antibodies to acetylcholine receptors.

This autoimmune disease is mediated by antibodies to acetylcholine receptors.

What is Myasthenia Gravis?

What is Myasthenia Gravis?


This reaction commonly occurs when bone marrow cells are

transplanted into an immunocompromised host.

This reaction commonly occurs when bone marrow cells are

transplanted into an immunocompromised host.

What is a graft-versus-host (GVH)

reaction?

What is a graft-versus-host (GVH)

reaction?WEILL CORNELL MEDICAL COLLEGE - QATAR

A 7 month old baby has a history of repeated ear infections and bacterialinfections, and has been hospitalized

with pneumonia twice. The babylikely has a deficiency of these cells.

A 7 month old baby has a history of repeated ear infections and bacterialinfections, and has been hospitalized

with pneumonia twice. The babylikely has a deficiency of these cells.

What are B cells?What are B cells?


These molecules are co-dominantly expressed on cells.

These molecules are co-dominantly expressed on cells.

What are MHC (major histocompatibility)

molecules?

What are MHC (major histocompatibility)

molecules?


The process whereby T cells learn to respond to antigen in

the context ofself MHC?

The process whereby T cells learn to respond to antigen in

the context ofself MHC?

What is MHC restriction?What is MHC restriction?


This substance enhances the immune response to an antigen

but does notconfer immunogenicity to a

hapten.

This substance enhances the immune response to an antigen

but does notconfer immunogenicity to a

hapten.

What is an adjuvant?What is an adjuvant?


These antigens bind outside the peptide binding groove on MHC class IImolecules and activate a family of T

cells.

These antigens bind outside the peptide binding groove on MHC class IImolecules and activate a family of T

cells.

What are superantigens?

What are superantigens?


A state of non responsiveness to antigen.

A state of non responsiveness to antigen.

What is anergy?What is anergy?


The site of T cell education.The site of T cell education.

What is the thymus?

What is the thymus?


This type of hypersensitivity reaction is produced by the local formation

of antigen-antibody aggregates which activate the complement cascade andcause acute intradermal inflammation.

This type of hypersensitivity reaction is produced by the local formation

of antigen-antibody aggregates which activate the complement cascade andcause acute intradermal inflammation.

What is the Arthus reaction?

What is the Arthus reaction?


This drug inhibits mast cell degranulation.

This drug inhibits mast cell degranulation.

What is sodium cromoglycate?What is sodium cromoglycate?


This cytokine is the principal mediator of the response to

gram negativebacteria. Its major cell source is

the activated phagocyte.

This cytokine is the principal mediator of the response to

gram negativebacteria. Its major cell source is

the activated phagocyte.

What is TNF?What is TNF?


This TH1 cytokine is a potent activator of macrophages and

upregulates theexpression of Class I and Class II MHC molecules on a variety of

celltypes.

This TH1 cytokine is a potent activator of macrophages and

upregulates theexpression of Class I and Class II MHC molecules on a variety of

celltypes.

What is IFN-g ?What is IFN-g ?


This motif which is found in the cytoplasmic domains of CD3 proteins

and inIga and IgB has important signaling

functions.

This motif which is found in the cytoplasmic domains of CD3 proteins

and inIga and IgB has important signaling

functions.

What is the immunoreceptor tyrosine based activation motifs

(ITAM)?

What is the immunoreceptor tyrosine based activation motifs

(ITAM)? WEILL CORNELL MEDICAL COLLEGE - QATAR

This immunosuppressive drug acts by specifically interfering

with theprotein kinases involved in IL-2/IL-2 receptor signaling.

This immunosuppressive drug acts by specifically interfering

with theprotein kinases involved in IL-2/IL-2 receptor signaling.What is Rapamycin

?What is Rapamycin

?


Hemolytic disease of the newborn is induced by transfer

of maternalantibodies of this isotype.

Hemolytic disease of the newborn is induced by transfer

of maternalantibodies of this isotype.

What are IgGs?What are IgGs?


This refers to the increase in the affinity of antibodies produced

duringthe course of a humoral immune

response.

This refers to the increase in the affinity of antibodies produced

duringthe course of a humoral immune

response.

What is affinity maturation ?

What is affinity maturation ?


Cytotoxic T cell lysis of target cells is mediated by the release

of thesesubstances from granules.

Cytotoxic T cell lysis of target cells is mediated by the release

of thesesubstances from granules.

What are perforin and granzyme B?What are perforin and granzyme B?


The process whereby Natural Killer cells can lyse antibody

coated target cells.

The process whereby Natural Killer cells can lyse antibody

coated target cells.

What is antibody dependent cell cytotoxicity (ADCC)?

What is antibody dependent cell cytotoxicity (ADCC)?


The phenomenon whereby a B cell produces an antibody of a

singlespecificity only.

The phenomenon whereby a B cell produces an antibody of a

singlespecificity only.

What is allelic exclusion?

What is allelic exclusion?


This disease arises as a consequence of a deficiency of

C1 inhibitor (C1INH).

This disease arises as a consequence of a deficiency of

C1 inhibitor (C1INH).

What is Hereditary angioneurotic

edema?

What is Hereditary angioneurotic

edema?WEILL CORNELL MEDICAL COLLEGE - QATAR

This is the process in which thymocytes whose TCRs bind

with high avidityto self MHC complexed with

antigen are eliminated.

This is the process in which thymocytes whose TCRs bind

with high avidityto self MHC complexed with

antigen are eliminated.

What is negative selection (or apoptosis)?

What is negative selection (or apoptosis)?


The ribbon like deposit of antibody along kidney basement

membranesis is characteristic of this disease.

The ribbon like deposit of antibody along kidney basement

membranesis is characteristic of this disease.

What is Goodpasture's

syndrome?

What is Goodpasture's

syndrome?WEILL CORNELL MEDICAL COLLEGE - QATAR

This receptor/ligand pair can mediate activation induced cell

death inT and B cells.

This receptor/ligand pair can mediate activation induced cell

death inT and B cells.

What is Fas/FasL (ligand)?

What is Fas/FasL (ligand)?


The interaction of this receptor/ligand pair is involved

in immunoglobulinheavy chain class switching.

The interaction of this receptor/ligand pair is involved

in immunoglobulinheavy chain class switching.

What is CD40/CD40L (ligand)?

What is CD40/CD40L (ligand)?


These cells constitute less than 5% of the peripheral T cell

population andthey appear in the thymus

before aB expressing T cells appear.

These cells constitute less than 5% of the peripheral T cell

population andthey appear in the thymus

before aB expressing T cells appear.

What are gd (gamma-delta) T

cells?

What are gd (gamma-delta) T

cells?WEILL CORNELL MEDICAL COLLEGE - QATAR

This zeta associated tyrosine kinase is involved in T cell

signaling.

This zeta associated tyrosine kinase is involved in T cell

signaling.

What is Zap-70?What is Zap-70?


While eating peanut butter cookies, an 8 year old boy began vomiting, had

difficulty in breathing and developed a swollen face. He was immediately

rushed to the hospital and was unconscious upon arrival. His bloodpressure was dangerously low. The most likely diagnosis of the child's

symptoms is?

While eating peanut butter cookies, an 8 year old boy began vomiting, had

difficulty in breathing and developed a swollen face. He was immediately

rushed to the hospital and was unconscious upon arrival. His bloodpressure was dangerously low. The most likely diagnosis of the child's

symptoms is?

What is anaphylactic shock?What is anaphylactic shock?WEILL CORNELL MEDICAL COLLEGE - QATAR

What should the child immediately be injected with in

order to raise hisblood pressure and facilitate his

breathing?

What should the child immediately be injected with in

order to raise hisblood pressure and facilitate his

breathing?What is

epinephrine?What is

epinephrine?


The symptoms that this child was experiencing were precipitated by

therelease of granules from this cell

type.

The symptoms that this child was experiencing were precipitated by

therelease of granules from this cell

type.

What are mast cells and/or basophils?

What are mast cells and/or basophils?


This membrane molecule has a cytoplasmic tail with two protein tyrosine phosphatase domains, which are thought to catalyze

dephosphorylation of a tyrosine residue of p56lck and p59fyn.

This membrane molecule has a cytoplasmic tail with two protein tyrosine phosphatase domains, which are thought to catalyze

dephosphorylation of a tyrosine residue of p56lck and p59fyn.

What is CD45?What is CD45?


About 90-99% of the peripheral T cells express this type of T cell

receptor.

About 90-99% of the peripheral T cells express this type of T cell

receptor.

What is abTCR?What is abTCR?


Macrophages in the kidney are called by this name.

Macrophages in the kidney are called by this name.

What are Kupffer cells?What are Kupffer cells?


This substance nonspecifically enhances or potentiates the

immune response to an antigen.

This substance nonspecifically enhances or potentiates the

immune response to an antigen.

What is an adjuvant?What is an adjuvant?


This is the invarient subunit that is associated with the

polymorphic a chain to form class I MHC molecule.

This is the invarient subunit that is associated with the

polymorphic a chain to form class I MHC molecule.

What is b2-microglobulin?

What is b2-microglobulin?


The phosphatase calcineurin dephosphorylates a cytoplasmic component of this transcription

factor.

The phosphatase calcineurin dephosphorylates a cytoplasmic component of this transcription

factor.

What is NFATc?What is NFATc?


This molecule is expressed by both resting and activated T

cells and binds with B moleculeon APC.

This molecule is expressed by both resting and activated T

cells and binds with B moleculeon APC.

What is CD28?What is CD28?


In this specific process, Natural Killer (NK) cells bind to

antitumor antibodies bound to the surface of the tumor cells

and lyse them.

In this specific process, Natural Killer (NK) cells bind to

antitumor antibodies bound to the surface of the tumor cells

and lyse them.

What is Antibody-Dependent Cell-mediated

Cytotoxicity, ADCC?

What is Antibody-Dependent Cell-mediated

Cytotoxicity, ADCC?


Phosphorylation of this allows it to hydrolyze phosphatidylinositol

4, 5- bisphosphate ( PIP2) into IP3 (inositol 1,4,5-triphosphate)

and DAG (diacylglycerol)

Phosphorylation of this allows it to hydrolyze phosphatidylinositol

4, 5- bisphosphate ( PIP2) into IP3 (inositol 1,4,5-triphosphate)

and DAG (diacylglycerol)

What is PLC-g1?What is PLC-g1?


This reaction develops when a graft contains

immunocompetent T cells that recognize and attack the

reciepient=s cells.

This reaction develops when a graft contains

immunocompetent T cells that recognize and attack the

reciepient=s cells.What is graft versus

host disease?What is graft versus

host disease?


Regions of vascular endothelium found in postcapillary venules of

various lymphoid organs that are composed of specialized

cells with plump cuboidal shape.

Regions of vascular endothelium found in postcapillary venules of

various lymphoid organs that are composed of specialized

cells with plump cuboidal shape.

What are called high endothelial venules?What are called high endothelial venules?


These small peptides attract different types of leukocytes and

regulate the expression and conformation of adhesion molecules on leukocyte

membranes.

These small peptides attract different types of leukocytes and

regulate the expression and conformation of adhesion molecules on leukocyte

membranes.

What are chemokines?

What are chemokines?


MIP-1a and MIP-1b belong to this subgroup of chemokines.

MIP-1a and MIP-1b belong to this subgroup of chemokines.

What is C-C subgroup of chemokines?

What is C-C subgroup of chemokines?


IL-8 belongs to this subgroup of chemokines.

IL-8 belongs to this subgroup of chemokines.

What is C-X-C subgroup?What is C-X-C subgroup?


This is Type II hypersensitive reaction in which maternal antibodies against fetal Rh

antigens cause hemolysis of the erythrocytes of a newborn.

This is Type II hypersensitive reaction in which maternal antibodies against fetal Rh

antigens cause hemolysis of the erythrocytes of a newborn.

What is Erythroblastosis fetalis?

What is Erythroblastosis fetalis?


Of the DNA binding proteins, only this is T cell specific.

Of the DNA binding proteins, only this is T cell specific.

What is NFAT?What is NFAT?


Diacylglycerol (DAG) activates protein kinase C (PKC) which mediates the release of this

transcription factor.

Diacylglycerol (DAG) activates protein kinase C (PKC) which mediates the release of this

transcription factor.

What is NF-kB?What is NF-kB?


Naive T cells and memory T cells are distinguished by these surface molecules using

immunofluorescence.

Naive T cells and memory T cells are distinguished by these surface molecules using

immunofluorescence.

What are CD45RA and CD45RO respectively?

What are CD45RA and CD45RO respectively?


This T helper subset functions more effectively as a helper for

B cell activation.

This T helper subset functions more effectively as a helper for

B cell activation.

What is Th2 subset?

What is Th2 subset?


This cytokine is secreted by activated macrophages in response to bacterial or

protozoan infections, which induces proliferation of NK cells

and Th1 cells resulting in incresed IFN-g production.

This cytokine is secreted by activated macrophages in response to bacterial or

protozoan infections, which induces proliferation of NK cells

and Th1 cells resulting in incresed IFN-g production.

What is IL-12?What is IL-12?


Inositol Triphosphate (IP3) triggers an increase in intracellular Ca2+ and

subsequent activation of this calmodulin-dependent

phosphatase.

Inositol Triphosphate (IP3) triggers an increase in intracellular Ca2+ and

subsequent activation of this calmodulin-dependent

phosphatase.

What is calcineurin?

What is calcineurin?


The transient increase in the number of circulating

neutrophils to indicate the presence of an infection is

medically denoted by this name.

The transient increase in the number of circulating

neutrophils to indicate the presence of an infection is

medically denoted by this name.What is

Leukocytosis?What is

Leukocytosis?


In the endocytotic pathway, within the endoplasmic

reticulum (RER), class II MHC molecules are associated with this, which blocks binding of

peptide.

In the endocytotic pathway, within the endoplasmic

reticulum (RER), class II MHC molecules are associated with this, which blocks binding of

peptide.

What is Invariant Chain?

What is Invariant Chain?


Bacterial septic shock develops when bacterial cell wall endotoxins stimulate

macrophages to overproduce these inflammatory cytokines.

Bacterial septic shock develops when bacterial cell wall endotoxins stimulate

macrophages to overproduce these inflammatory cytokines.

What are IL-1 and TNF-a?

What are IL-1 and TNF-a?


This is a potent proteolytic enzyme that breaks down fibrin clots in to degradation products.

This is a potent proteolytic enzyme that breaks down fibrin clots in to degradation products.

What is plasmin?What is plasmin?


These strands criss-cross one another to form a clot which

serves as barrier to the spread of infection.

These strands criss-cross one another to form a clot which

serves as barrier to the spread of infection.

What are fibrin strands?

What are fibrin strands?


This end product of the kinin system is a potent vasoactive basic peptide that increases

vascular permeability, causes vasodilation, induces pain, and induces contraction of smooth

muscle.

This end product of the kinin system is a potent vasoactive basic peptide that increases

vascular permeability, causes vasodilation, induces pain, and induces contraction of smooth

muscle.What is

bradykinin?What is

bradykinin?


Prostaglandins are produced by the metabolism of this via the

cyclooxygenase pathway.

Prostaglandins are produced by the metabolism of this via the

cyclooxygenase pathway.

What is Arachidonic acid?

What is Arachidonic acid?


This is an immunosuppressive drug commonly used to prevent

graft rejection.

This is an immunosuppressive drug commonly used to prevent

graft rejection.




This T helper subset is responsible for classical cell mediated functions such as

delayed type hypersensitivity.

This T helper subset is responsible for classical cell mediated functions such as

delayed type hypersensitivity.

What is Th1 subset?

What is Th1 subset?


The initial activation of both T cells and B cells is thought to take place in this region of the

lymphonode.

The initial activation of both T cells and B cells is thought to take place in this region of the

lymphonode.

What is paracortex?

What is paracortex?


This cytokine is produced by TH1 cells and can induce

macrophages to increase MHC class II expression.

This cytokine is produced by TH1 cells and can induce

macrophages to increase MHC class II expression.

What is IFN gamma?

What is IFN gamma?


Absence of this receptor in T cells is associated with hyper

IgM syndrome.

Absence of this receptor in T cells is associated with hyper

IgM syndrome.

What is CD40L?What is CD40L?


These cells reside in the skin and are major antigen-

presenting cells.

These cells reside in the skin and are major antigen-

presenting cells.

What are Langerhans cells?

What are Langerhans cells?


These drugs block H1 and H2 receptors on target cells and is

used to treat atopy.

These drugs block H1 and H2 receptors on target cells and is

used to treat atopy.

What are antihistamines?

What are antihistamines?


Also called multi-colony-stimulating factor, this cytokine stimulates growth of precursors of most bone marrow-derived

cells.

Also called multi-colony-stimulating factor, this cytokine stimulates growth of precursors of most bone marrow-derived

cells.What is IL-3?What is IL-3?


Defects in enzymes involved in nucleotide degradation lead to this

SCID which leads to accumulation of nucleotide metabolites.

Defects in enzymes involved in nucleotide degradation lead to this

SCID which leads to accumulation of nucleotide metabolites.

What is adenosine deaminase deficiency? OR What is purine

nucleotide phosphorylase deficiency?

OR What is ADA deficiency?

What is adenosine deaminase deficiency? OR What is purine

nucleotide phosphorylase deficiency?

OR What is ADA deficiency?


Folding of this region of the Ig molecule produces a cleft in

which binding of antigen occurs.

Folding of this region of the Ig molecule produces a cleft in

which binding of antigen occurs.

What is the hypervariable

region?

What is the hypervariable

region?WEILL CORNELL MEDICAL COLLEGE - QATAR

Digestion of anti-sheep red blood cell (SRBC) antibodies with

this enzyme will result in a reagent which will still agglutinate SRBC.

Digestion of anti-sheep red blood cell (SRBC) antibodies with

this enzyme will result in a reagent which will still agglutinate SRBC.

What is pepsin?What is pepsin?


This joining rule assures proper VL-JL or VH-DH-JH joining during

rearrangement of immunoglobulin genes.

This joining rule assures proper VL-JL or VH-DH-JH joining during

rearrangement of immunoglobulin genes.

What is the 12/23 joining rule?

What is the 12/23 joining rule?


The antigen-independent phase of B cell differentiation occurs

here.

The antigen-independent phase of B cell differentiation occurs

here.


What is the bone marrow?

What is the bone marrow?

The presence of this chain within the endoplasmic reticulum is thought to prevent peptide

binding to class II MHC molecules during antigen

processing.

The presence of this chain within the endoplasmic reticulum is thought to prevent peptide

binding to class II MHC molecules during antigen

processing.

What is the invariant chain?

What is the invariant chain?


Upon activation of T cells, expression of this ensures that

only activated cells will undergo proliferative responses to

antigen.

Upon activation of T cells, expression of this ensures that

only activated cells will undergo proliferative responses to

antigen.

What is IL-2R? OR What is Interleukin-2-receptor? OR

What is IL-2 receptor?

What is IL-2R? OR What is Interleukin-2-receptor? OR

What is IL-2 receptor?


Eskimos get these when sitting on the ice too long.

Eskimos get these when sitting on the ice too long.

What are Polaroids?What are Polaroids?


Molecular mimicry is one mechanism proposed to account

for the development of this.

Molecular mimicry is one mechanism proposed to account

for the development of this.

What is autoimmunity?

What is autoimmunity?


Phagocytic activity of macrophages and neutrophils is promoted by interferon gamma

and this other cytokine.

Phagocytic activity of macrophages and neutrophils is promoted by interferon gamma

and this other cytokine.

What is tumor necrosis factor alpha OR what is TNF alpha OR

what is TNFa?

What is tumor necrosis factor alpha OR what is TNF alpha OR

what is TNFa?


Immunity to bacterial infections is usually mediated by these

unless the organism is capable of intracellular growth.

Immunity to bacterial infections is usually mediated by these

unless the organism is capable of intracellular growth.

What are antibodies?What are antibodies?


This form of SCID is caused by a deficiency in class I or class II

MHC expression.

This form of SCID is caused by a deficiency in class I or class II

MHC expression.

What is Bare lymphocyte syndrome?

What is Bare lymphocyte syndrome?


This is the process by which rearranged genes for heavy and

light chains from only one chromosome are expressed.

This is the process by which rearranged genes for heavy and

light chains from only one chromosome are expressed.

What is allelic exclusion?What is allelic exclusion?


Lymphocytes migrate from the blood to lymphoid organs

through these.

Lymphocytes migrate from the blood to lymphoid organs

through these.

What are HEV OR What are high endothelial venules?

What are HEV OR What are high endothelial venules?


THE THE ENDEND


Documents

JEOPARDY WEILL CORNELL MEDICAL COLLEGE - QATAR This costimulator is expressed by professional APCs including B cells, dendritic cells, and macrophages