Ocata Therapeutics Corporate Presentation Jefferies Healthcare Conference – June 1, 2015

Cautionary Statement Concerning Forward-Looking Statements

Ocata Therapeutics Inc. (“Ocata” or “the Company”) has filed a registration statement (including a prospectus and a preliminary prospectus supplement) with the Securities and Exchange Commission (“SEC”) for the offering to which this presentation relates. Before you invest you should read the prospectus and the preliminary prospectus supplement in that registration statement and other documents the Company has filed with the SEC for more complete information about the Company and the offering. You mayget these documents for free on the SEC’s website at http://www.sec.gov

These slides and the accompanying oral presentation contain statements that are not historical facts and are considered forward-looking information. In some cases you can identify these statements by forward-looking words such as “anticipate,” “believe,” “could,” “continue,” “estimate,” “expect,” “intend,” “may,” “should,” “will”, “would,” ”plan,” ”projected,” or the negative of such words or other similar words or phrases. Investors are cautioned not to unduly rely on forward-looking statements because they involve risks and uncertainties and statements related to future events or our future financial performance, and involve known and unknown risks, uncertainties and other factors that may cause our actual results, levels of activity, performance or achievements to be materially different from any future results, levels of activity, performance or achievements expressed or implied by these forward-looking statements. These statements are also subject to a number of material risks and uncertainties that are described more fully in the prospectus and the preliminary prospectus supplement filed with the SEC, including without limitation our mostrecently filed Annual Report on Form 10-K, as amended, and our most recently filed Quarterly Report on Form 10-Q, as filed withthe SEC. These forward-looking statements speak only as of the date on which the statements were made and are not guarantees offuture performance. Except as may be required by applicable law, we do note undertake or indent to update any forward-looking statements contained herein or in our public filings wit the SEC.

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Addressing Macular Degeneration with Groundbreaking RPE Therapy

The Regenerative Ophthalmology™ Company

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Safety observed, in addition

to anatomical and functional

evidence of repair and

restoration in Phase 1 studies

for dry AMD and SMD

• Data published in The Lancet,

October 14, 2014

• Data in Asian patients published

in Stem Cells, April 30, 2015

Initiating Pivotal and Phase 2

studies:

• Stargardt’s Macular

Degeneration (SMD) – Pivotal

- H2 2015

• Dry Age-related Macular

Degeneration (AMD) – Phase 2

- Q3 2015

Addressing Macular

Degeneration with two

product candidates:

• An orphan indication in

SMD, followed by a

• Potential blockbuster in

AMD, based on patient

data in the US and EU

• ATMP status in Europe

Organ Transplantation is Well-Established, Our RPE Products are Simple Micro Transplants of

Support Cells required for Functioning Infrastructure at the Back of the Eye

Recent Milestones Demonstrate Continued Execution Against Plan

Milestone Significance

• Completion of P1/2 studies at highest dose (200k cells)

• SMD pivotal trial protocol agreed with EMA

• Up-listing of company stock to NASDAQ

• Publication of data in Asian patients (SMD & AMD)

• Expanded technology to include IPSCs via Allele Deal

• Three US patents issued covering RPE Program

• Safety in 42 patients, some with >3 years of follow up

• Confidence in commercial timing, 2019

• Increased liquidity, index funds and broader investor audience

• Supportive of US/UK trials, independently managed trial

• Bolsters pre-clinical pipeline and diversifies platform

• Potential to block all current competitors

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Milestones in 1H 2015 Position Company for Success in Next 12 – 18 Months…

Future Milestones to Bolster Position as

The Leading Regenerative Ophthalmology Company

Year Period Goal

2015

Q3

• Dry AMD Phase 2 Study: First subject enrolled

• Special Protocol Assessment meeting with FDA

• SMD Pivotal Study: First subject enrolled

• Further strengthening of IP portfolio

Q4• Publication of data on pre-clinical photoreceptor studies

• Partnership of non-core asset (e.g. platelet program)

2016

Q2 • Dry AMD P2 Study: First Cohort with 3 month data

Q3• Dry AMD P2 Study: Second Cohort with 3 month data

• Partnership of core program in ex-US region (e.g. Asia, South America)

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As Milestones are Achieved, Ocata will Continue to Broaden Market Awareness

RPE Damage and Subsequent Photoreceptor Degeneration Leads

to Loss of Central Visual Acuity

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The First Evidence of Long-term Safety and Efficacy Signal Following

Transplantation of RPE Cells – October 2014

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“What we did is transplant the cells into patients who have a disease where those particular cells are dying; and we replaced those dying tissues with new tissue that's derived from these stem cells. In a way it's a retinal transplant.

- Steven Schwartz, eye specialist, UCLA

Further Evidence of Long-term Safety and Efficacy Signal in Asian Patients with

SMD and AMD – April 2015

Four Korean patients: two with dry AMD and two with SMD

Patients were followed for 1 year – No evidence of adverse proliferation, tumorigenicity, ectopic tissue

formation, or other serious safety issues related to the transplanted cells.

– Visual acuity improved 9–19 letters in three patients and remained

stable (+1 letter) in one patient.

Total of forty two patients safely treated worldwide with RPE Therapy.

Independent trial in Asian population supports previously reported safety and efficacy signals

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World Leaders in Terminal Differentiation of Pluripotent to Target Cells with

Proprietary DeltaCellTM Technology

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Pluripotent

Stem Cells

Starting Source

Stem Cells are the Starting Material but Fully Differentiated Cells are the Treatment

hESC

iPSC

Corneal

Retinal Ganglion

Photoreceptor

Retinal Pigment Epithelium

Terminally

Differentiated

Cells For

Transplantation

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3 4

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Addressing a Spectrum of Ocular Disorders with other Terminally Differentiated Cells

Photoreceptor Progenitor Cells

• Macular Degeneration -

dry AMD, SMD, MMD

• Retinitis Pigmentosa

Retinal Ganglion Progenitor Cells

• Glaucoma

Mesenchymal Stem Cells

• Uveitis

• Management of Ocular Surfaces

Corneal Endothelial Therapy

• Corneal Disease

1

2

3

4

Rich preclinical pipeline of Regenerative Ophthalmology product opportunities

each addressing large unmet medical needs

Ophthalmic Development Pipeline Includes SMD, Dry AMD and MMD

Pre-

clinical IND Phase 1 Phase 2

SMD

Dry AMD

MMD

Photoreceptors

Ganglion Cells

Cornea

Phase 2 Study

for Dry AMD,

Pivotal Trial for

SMD (Orphan)

Opportunity for

additional IND’s

Planned Commercial Launch for Stargardt’s Macular Degeneration in 2019

Multiple Opportunities for Product Development and Commercialization

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Immune privileged

– Less prone to rejection

Compact Structure

– Relatively small doses required

to treat

Straightforward delivery using

currently available technology

Validated tools for clinical outcome

assessment

The Eye is Well-Suited for Cellular Transplantation

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Patients in the Ocata Studies with more than Three Years Post Transplant

Experience, Continue to Show Positive Safety Signals with Visual Acuity Gains

Well-defined prescriber base

– Patients are referred to retinal specialists (~2,500 in the US of which ~1,500- 2,000 are vitreoretinal

surgeons) who diagnose and manage subsequent patient care

– Market penetration achievable with a small salesforce; ~50 reps in the US

Ease of administration: cellular transplantation performed with current technology

– Utilizes pars plana vitrectomy (more than one million procedures in the US already being completed, p.a.)

and subretinal injection (~90 seconds added to vitrectomy procedure) modalities scalable to surgeons

Small dosage requirement

– Commercial scalability of manufacturing and distribution in process

Significant unmet medical need – no approved treatments for dry AMD or SMD

– Approximately 1.8 million new dry-AMD patients diagnosed per year in the US

– Approximately 90,000 patients currently suffering from SMD in US and EU

SMD, Dry AMD and MMD are Specialized Opportunities

and Feasible for an Emerging Biotech

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A Viable Standalone Plan Creates Leverage with Potential Partners

Clinical Programs

RPE for SMD, Dry AMD and MMD

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Required for vision and maintenance of

photoreceptor health

Delivers and metabolizes Vitamin A

– Recycles photopigments

Phagocytosis of photoreceptor outer segments

Transport of metabolic waste from retina to

choriocapillaris

Absorbs stray light for improved image resolution

Secretes growth and survival factors needed for

photoreceptor differentiation

Retinal Pigment Epithelium: Vital for Photoreceptor Health

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Loss of RPE Layer Results in Loss of Vision

Ocata’s Therapeutic Approach is to Transplant New RPE Layer and Help Restore Vision

Normal Physiology, RPE in Intimate Contact with Photoreceptors and

Provide Vital Life Support

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Macular Degeneration Leads to RPE Loss

Photoreceptors incur Damage, Dormancy and eventual Death

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Ocata’s Therapeutic Approach is to Deliver “Brand New” Terminally

Differentiated RPE Cells via Sub-Retinal Injection

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Data Indicate Transplantation of New RPE Can Lead to Restoration of

Anatomy & Function

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Neural signal restored

Macular Degeneration – Long Term

Data in SMD and Dry AMD

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D. Black dashed circle outlining area of subretinal transplantation

E. Green rectangle overlying white dashed arrow demonstrating optical coherence tomographic section at

baseline and at 6 months following subretinal MA09-hRPE injection

F. White arrows demonstrating persistence of subretinal pigment epithelial cells 12 months post-

transplantation

Phase 1/2 Studies Presented Evidence of Engraftment;

Transplanted Cells Take Residence, as Intended

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Baseline* Month 6*

Anatomic Evidence of Successful Engraftment Illustrates that Transplant is

Rebuilding the Support Structure in the Back of the Eye

Interim Data for AMD and SMD Lancet Study Showed that BCVA Improved

and was Sustained Over the Long-Term

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Efficacy Signal and Safety Persists in Treated Eyes

Lancet publication: May 2014

Dry AMD

0.0

17.917.0

16.314.7

0.0

7.6 8.0

2.40.8

-5.0

0.0

5.0

10.0

15.0

20.0

25.0

0 31 60 91 121 152 182 213 244 274 305 335 366

Mean

Ch

an

ge f

rom

Baselin

e (

lett

ers

)

Days after transplant

8 Subjects with 12 Month Follow-up

Treated Eye Untreated Eye

0.0

5.8

7.8

9.09.8

0.0

5.4 5.24.2 4.6

0.0

5.0

10.0

15.0

0 31 60 91 121 152 182 213 244 274 305 335Me

an

Ch

an

ge

fro

m B

as

elin

e in

BC

VA

(le

tte

rs)

Days After Transplant

5 Subjects with 12 Months Follow-up

Treated Eye Untreated Eye

Lancet publication: May 2014

SMD

Available Interim Data for AMD Study Showed that BCVA Improved

and was Sustained Over Two Years

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Efficacy Signal and Safety Persists in Treated Eyes for Two Years

Now Moving to Controlled Phase 2 Study

March 2015

Dry AMD Data

0.0

6.25.4 5.2

6.07.2

8.2

0.01.6

5.24.4

-0.4

-3.2

-1.2-5.0

0.0

5.0

10.0

15.0

20.0

25.0

0 60 121 182 244 305 366 425 486 547 609 670 731

Mean

Ch

an

ge

in B

CC

VA

(le

tters

)

Days After Transplant

5 Subjects with 24 Month Follow-up

Treated Eye Untreated Eye

Clinical Program Design

Pivotal SMD Trial and Phase 2 Dry AMD Trial

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Objectives– Pivotal Controlled Study to demonstrate safety and efficacy of RPE cell transplant therapy

– Designed to confirm efficacy signal seen in prior studies

– Will include untreated masked control group, consistent with EMA and FDA guidance

Design Highlights– Double-masked study

– 1:1 Randomization (N=100, 50 treated : 50 control)

First patient treatment expected in 2H 2015 following SPA meeting with FDA, full enrollment expected in 2017 (Anatomy and Efficacy)

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SMD Pivotal Trial, Planned Initiation in the Second Half of 2015

Trial Designed to Enable Potential Approval in 2019

Objectives

– Safety & tolerability of 3 different immunosuppressive regimens (13,7 and 1 week(s))

– Note - No evidence of any transplant rejection to date in patients treated up to four years

– Exploring efficacy signal seen in previous open studies

– Will include a “better vision” arm

Design Highlights

– Control group of untreated patients

– Three cohorts of 20 patients

– 3:1 Randomization (N=60, 40 treated : 20 control)

First Cohort Data read out expected Q2 2016 ( Anatomy and Efficacy Signal)

AMD Phase 2 Safety & Proof-of-Concept, Planned Initiation - Q3 2015

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Corporate

Success in this Controlled Study will support SMD Program and Further RPE Therapy as a

Transformational Therapy that Could Provide Benefit for Patients with SMD and Dry AMD

Pre-Clinical Pipeline

Photoreceptor Progenitors

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Pre-Clinical Pipeline is Maturing - Ocata’s Technology Extends Beyond hESCs

and includes Induced Pluripotent Cells (iPSCs)

Photoreceptor Progenitors were transplanted into mice with

severe retinal degeneration

After 3 weeks, mice showed significant improvement with the

number of surviving cells in each animal strongly correlated

to magnitude of visual improvement

Similar efficacy using either human ESC or iPS cells

processed using our DeltaCell™ Technology

Pre-clinical Data Expected H2 2015, this Product could Compliment RPE Therapy

as Viable Potential Solution for End-Stage Disease

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Systemic hESC-PhRPs Provide Neuroprotection in Mice and Rats

a-wave(cones & rods) PhRP, 2 mo

PhRP, 1 mo

PBS, 1 mo

PBS, 2 mo

Prevent photoreceptor

degeneration in ELOVL4 mice

ONL→

PBS control

Intravitreal injection

missing OS (P90)

PhPR-treated

(rod OS/rhodopsin)

Preserve outer segments of

photoreceptor in RCS rats

Tail vein injection

Healthy ONL

Missing ONL

PhRPs rescue photoreceptors in RCS rats

Healthy ONL

Missing ONL

0

10

20

30

40

50

60

PB

S

No

In

jection

RA

2 m

on

th

Increased ONL thickness after 2 months

PBS Ø Tx

Operations and Corporate

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Ocata Therapeutics DeltaCell™ Technology

Manufacturing Process in cGMP Environment

Continued Investment and Advances in Manufacturing and Delivery Generates Expansion of IP Estate

Cryopreserved – inexhaustible replicative capacity starting

material, stored at Ocata and in remote location

Master Cell Bank of

hESC’s

Induction of proliferation and cell culture expansionExpansion of cells

~20 fold

In-process assays to ensure morphology and

sterility of cells

Shift to Terminal

Differentiation

to RPE cells

The process of re-passaging the cells can produce >1,000

fold increase of quantity of RPE cells

Purify RPE and

re-passage to

expand quantity

Available for patient dosing; one five month process

typically yields ~1,000 doses

Harvest bulk material

and cryopreserve

RPE inventory

12 full-time employees

dedicated to manufacturing,

quality control, quality

assurance & assay

development

FDA review of CMC accepting

of release criteria and

processes

Step

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IP Coverage From Stem Cell Line to Patient Treatment

Single Blastomere Derivation of hESCs Methods of Manufacturing hESC-derived RPE cells

Product Release AssaysPharmaceutical PreparationsMethods-of-Treatment

3 Patent Families

• 13 Issued Patents

• 26 Pending Applications

Core Patent expiry – 2031 (with Patent Term Extension)

5 Patent Families

• 2 Issued Patents

• 34 Pending Applications

Core Patents - 2031

Formulation Improvements - 2032

Shipping Medium –2035

3 Patent Families

• 4 Issued Patents

• 26 Pending Applications

Core Patents - 2031

Improvements - 2032

2 Patent Family

• 11 Pending Applications

Expiry will begin 2031 & 2032

1 Patent Family

• 4 Issued Patents

• 12 Pending Applications

Expiry begins 2025

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• Trades on Nasdaq – OCAT

• March 31, 2015 cash balance - $3.5m

• Currently funded from $30m equity line

with Lincoln Park Capital, of which

~$8m remains

• ~35.6m shares outstanding

– no preferred stock

– no debt

– ~2.8m options and RSU’s held by

management and directors

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Ocata Therapeutics Financial Overview

Future Milestones to Bolster Position as

The Leading Regenerative Ophthalmology Company

Year Period Goal

2015

Q3

• Dry AMD Phase 2 Study: First subject enrolled

• Special Protocol Assessment meeting with FDA

• SMD Pivotal Study: First subject enrolled

• Further strengthening of IP portfolio

Q4• Publication of data on pre-clinical photoreceptor studies

• Partnership of non-core asset (e.g. platelet program)

2016

Q2 • Dry AMD P2 Study: First Cohort with 3 month data

Q3• Dry AMD P2 Study: Second Cohort with 3 month data

• Partnership of core program in ex-US region (e.g. Asia, South America)

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As Milestones are Achieved, Ocata will Continue to Broaden Market Awareness

An Experienced Management Team

Name Position Experience

Paul K. Wotton, Ph.D. President & CEO

Edward (Ted) MylesChief Operating Officer &Chief Financial Officer

Robert Lanza, M.D. Chief Scientific Officer

Eddy Anglade, M.D. Chief Medical Officer

LeRoux Jooste Chief Commercial Officer

PENWEST

Experienced Corporate & Scientific Boards

Name Experience

Michael Heffernan,

(Chairman)CEO – Collegium Pharmaceuticals

Robert Langer, Sc.D.Institute Professor – Massachusetts Institute of

Technology

Greg Perry EVP & CFO – Eleven Biotherapeutics

Alan C. Shapiro

Finance Professor and Chairman, Department of

Finance and Business Economics (retired) –

University of Southern California

Zohar LoshitzerPresident – Presbia, Inc., & Principal at Orchard

Capital

Paul K. Wotton, Ph.D. President and CEO, Ocata Therapeutics

World Class Scientific Advisory Board

Name Experience

Robert Langer, Sc.D.

(Chairman)

Massachusetts Institute of Technology

Queen Elisabeth Prize for Engineering (2015); Member

of all 3 National Academies; President’s National

Medal of Technology and Innovation (2013)

Constance Cepko, Ph.D.Harvard Medical School

National Academy of Sciences (elected 2002); Alfred

W. Bressler Prize in Vision Science (2011)

George Daley, M.D., Ph.D.Harvard Medical School

NIH Director’s Pioneer Award (2004); E. Mead Johnson

Award from the American Pediatric Society (2009)

John Gearhart, Ph.D.University of Pennsylvania

Director of the Institute for Regenerative Medicine;

Science, Board of Reviewing Editors

Michael Longaker, M.D.

Stanford University

Director, Institute of Stem Cell Biology and

Regenerative Medicine; Director, Children's Surgical

Research

Joseph Vacanti, M.D.Massachusetts General Hospital

Surgeon-in-Chief; Member, Institute of Medicine of the

National Academy of Sciences

Board of Directors – Broad Experience in Life Science Sector

Initiating Pivotal Trial for SMD and Phase 2 Study for dry AMD with novel, potentially curative therapy in areas where no approved products exist today

Dry AMD is a potential blockbuster indication – a precursor to Wet AMD where Treatments include Eylea (Regeneron) and Lucentis (Novartis/Roche)

Safety observed, in addition to anatomical and functional evidence of repair and restoration; data published in The Lancet, October 14th, 2014 and data in Asian Patients published on April 30th 2015 in Stem Cell Reports

Established and growing IP position in major markets protecting the life span of the cell therapy – from the origin of the cell to the delivery into patients’ eyes

Novel and world leading pre-clinical pipeline

Ability to produce fully differentiated cell types (e.g. RPE, PhRP) with DeltaCell™ Technology

Experienced management team, corporate and scientific boards

The World Leader in Regenerative Ophthalmology

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