Consolidated TOC for APS Journals – January 1, 2016

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January 1, 2016; volume 310, issue 1

The below Table of Contents is available online at: http://ajpcell.physiology.org/content/current

CALL FOR PAPERS | Cell Signaling: Proteins, Pathways and Mechanisms

Delivery of a protein transduction domain-mediated Prdx6 protein ameliorates oxidative stress-induced injury in human and mouse neuronal cellsShatrunjai P. Singh, Bhavana Chhunchha, Nigar Fatma, Eri Kubo, Sanjay P. Singh, Dhirendra P. SinghJanuary 1, 2016 : C1-C16

DOI: 10.1152/ajpcell.00229.2015

Editorial Focus

More roles for the (passive) giant. Focus on “The increase in non-cross-bridge forces after stretch of activated striated muscle is related to titinisoforms”Darren T. Hwee, Jeffrey R. JasperJanuary 1, 2016 : C17-C18

DOI: 10.1152/ajpcell.00310.2015

Articles

The increase in non-cross-bridge forces after stretch of activated striated muscle is related to titin isoformsAnabelle S. Cornachione, Felipe Leite, Maria Angela Bagni, Dilson E. RassierJanuary 1, 2016 : C19-C26

DOI: 10.1152/ajpcell.00156.2015

Slow recovery of the impaired fatigue resistance in postunloading mouse soleus muscle corresponding to decreased mitochondrial function and acompensatory increase in type I slow fibersHan-Zhong Feng, Xuequn Chen, Moh H. Malek, J.-P. JinJanuary 1, 2016 : C27-C40

DOI: 10.1152/ajpcell.00173.2015

Inhibition of Notch signaling pathway attenuates sympathetic hyperinnervation together with the augmentation of M2 macrophages in rats post-myocardial infarctionJie Yin, Hesheng Hu, Xiaolu Li, Mei Xue, Wenjuan Cheng, Ye Wang, Yongli Xuan, Xinran Li, Na Yang, Yugen Shi, Suhua YanJanuary 1, 2016 : C41-C53

DOI: 10.1152/ajpcell.00163.2015

CUGBP1 and HuR regulate E-cadherin translation by altering recruitment of E-cadherin mRNA to processing bodies and modulate epithelial barrierfunctionTing-Xi Yu, Bei-Lin Gu, Jun-Kai Yan, Jie Zhu, Wei-Hui Yan, Jie Chen, Lin-Xi Qian, Wei CaiJanuary 1, 2016 : C54-C65

DOI: 10.1152/ajpcell.00112.2015

Lewis lung carcinoma regulation of mechanical stretch-induced protein synthesis in cultured myotubesSong Gao, James A. CarsonJanuary 1, 2016 : C66-C79

DOI: 10.1152/ajpcell.00052.2015

Nitrotyrosine impairs mitochondrial function in fetal lamb pulmonary artery endothelial cellsRu-Jeng Teng, Tzong-Jin Wu, Adeleye J. Afolayan, Girija G. KonduriJanuary 1, 2016 : C80-C88

DOI: 10.1152/ajpcell.00073.2015

F-actin clustering and cell dysmotility induced by the pathological W148R missense mutation of filamin B at the actin-binding domainYongtong Zhao, Sandor S. Shapiro, Masumi EtoJanuary 1, 2016 : C89-C98

DOI: 10.1152/ajpcell.00274.2015

Copyright © 2016 by the American Physiological Society.

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January 1, 2016; volume 310, issue 1

The below Table of Contents is available online at: http://ajpendo.physiology.org/content/current

Review

Advances in high-density lipoprotein physiology: surprises, overturns, and promisesCaterina Constantinou, Eleni A. Karavia, Eva Xepapadaki, Peristera-Ioanna Petropoulou, EugeniaPapakosta, Marilena Karavyraki, Evangelia Zvintzou, Vassilis Theodoropoulos, Serafoula Filou,Aikaterini Hatziri, Christina Kalogeropoulou, George Panayiotakopoulos, Kyriakos E. KypreosJanuary 1, 2016 : E1-E14

DOI: 10.1152/ajpendo.00429.2015

Translational Physiology

Stromal cell-derived factor-1 mediates changes of bone marrow stem cells during the bone repair processKiyotaka Okada, Naoyuki Kawao, Masato Yano, Yukinori Tamura, Shinzi Kurashimo, Katsumi Okumoto, Kotarou Kojima, Hiroshi KajiJanuary 1, 2016 : E15-E23

DOI: 10.1152/ajpendo.00253.2015

Articles

The impact of a human IGF-II analog ([Leu27]IGF-II) on fetal growth in a mouse model of fetal growth restrictionJayne C. Charnock, Mark R. Dilworth, John D. Aplin, Colin P. Sibley, Melissa Westwood, Ian P. CrockerJanuary 1, 2016 : E24-E31

DOI: 10.1152/ajpendo.00379.2015

OPEN ACCESS ARTICLE

Increased intramyocellular lipid/impaired insulin sensitivity is associated with altered lipid metabolic genes in muscle of high responders to a high-fat dietSaori Kakehi, Yoshifumi Tamura, Kageumi Takeno, Yuko Sakurai, Minako Kawaguchi, TakahiroWatanabe, Takashi Funayama, Fumihiko Sato, Shin-ichi Ikeda, Akio Kanazawa, Yoshio Fujitani, Ryuzo Kawamori, Hirotaka Watada

January 1, 2016 : E32-E40

DOI: 10.1152/ajpendo.00220.2015

Short-term sleep deprivation with nocturnal light exposure alters time-dependent glucagon-like peptide-1 and insulin secretion in male volunteersManuel Gil-Lozano, Paola M. Hunter, Lucy-Ann Behan, Bojana Gladanac, Robert F. Casper, Patricia L. BrubakerJanuary 1, 2016 : E41-E50

DOI: 10.1152/ajpendo.00298.2015

Diacylglycerol kinase-δ regulates AMPK signaling, lipid metabolism, and skeletal muscle energeticsLake Q. Jiang, Thais de Castro Barbosa, Julie Massart, Atul S. Deshmukh, Lars Löfgren, Daniella E.Duque-Guimaraes, Arda Ozilgen, MeganE. Osler, Alexander V. Chibalin, Juleen R. ZierathJanuary 1, 2016 : E51-E60

DOI: 10.1152/ajpendo.00209.2015

Equine hyperinsulinemia: investigation of the enteroinsular axis during insulin dysregulationM. A. de Laat, J. M. McGree, M. N. SillenceJanuary 1, 2016 : E61-E72

DOI: 10.1152/ajpendo.00362.2015

OPEN ACCESS ARTICLE

The anabolic response to a meal containing different amounts of protein is not limited by the maximal stimulation of protein synthesis in healthyyoung adultsIl-Young Kim, Scott Schutzler, Amy Schrader, Horace J. Spencer, Gohar Azhar, Arny A. Ferrando, Robert R. WolfeJanuary 1, 2016 : E73-E80

DOI: 10.1152/ajpendo.00365.2015

Enhanced insulin sensitivity mediated by adipose tissue browning perturbs islet morphology and hormone secretion in response to autonomicnervous activation in female miceBilal A. Omar, Martina Kvist-Reimer, Sven Enerbäck, Bo AhrénJanuary 1, 2016 : E81-E90

DOI: 10.1152/ajpendo.00296.2015

The MAFB transcription factor impacts islet α-cell function in rodents and represents a unique signature of primate islet β-cellsElizabeth Conrad, Chunhua Dai, Jason Spaeth, Min Guo, Holly A. Cyphert, David Scoville, Julie Carroll, Wei-Ming Yu, Lisa V. Goodrich, DavidM. Harlan, Kevin L. Grove, Charles T. Roberts, Alvin C. Powers, Guoqiang Gu, Roland SteinJanuary 1, 2016 : E91-E102

DOI: 10.1152/ajpendo.00285.2015

Copyright © 2016 by the American Physiological Society.

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January 1, 2016; volume 310, issue 1

The below Table of Contents is available online at: http://ajpgi.physiology.org/content/current

Liver and Biliary Tract Physiology/Pathophysiology

Podoplanin discriminates distinct stromal cell populations and a novel progenitor subset in the liverChristoph Eckert, Yong Ook Kim, Henrike Julich, Eva-Carina Heier, Niklas Klein, Elmar Krause,Thomas Tschernig, Miroslaw Kornek, Frank Lammert, Detlef Schuppan, Veronika Lukacs-Kornek

January 1, 2016 : G1-G12

DOI: 10.1152/ajpgi.00344.2015

PKCα regulates TMEM16A-mediated Cl− secretion in human biliary cellsAmal K. Dutta, Al-Karim Khimji, Songling Liu, Zemfira Karamysheva, Akiko Fujita, Charles Kresge, Don C. Rockey, Andrew P. FeranchakJanuary 1, 2016 : G34-G42

DOI: 10.1152/ajpgi.00146.2015

Pancreatic Physiology/Pathophysiology

Glucagon-like peptide-1 receptor is present in pancreatic acinar cells and regulates amylase secretion through cAMPYanan Hou, Stephen A. Ernst, Kaeli Heidenreich, John A. WilliamsJanuary 1, 2016 : G26-G33

DOI: 10.1152/ajpgi.00293.2015

Inflammation, Immunity, and Infection

Elevated IL-33 expression is associated with pediatric eosinophilic esophagitis, and exogenous IL-33 promotes eosinophilic esophagitis developmentin miceL. M. Judd, R. G. Heine, T. R. Menheniott, J. Buzzelli, N. O'Brien-Simpson, D. Pavlic, L. O'Connor, K. Al Gazali, O. Hamilton, M. Scurr, A.M. Collison, J. Mattes, K. J. Allen, A. S. GiraudJanuary 1, 2016 : G13-G25

DOI: 10.1152/ajpgi.00290.2015

Nutrient Sensing, Nutrition, and Metabolism

Cephalic phase secretion of insulin and other enteropancreatic hormones in humansSimon Veedfald, Astrid Plamboeck, Carolyn F. Deacon, Bolette Hartmann, Filip K. Knop, Tina Vilsbøll, Jens J. HolstJanuary 1, 2016 : G43-G51

DOI: 10.1152/ajpgi.00222.2015

Copyright © 2016 by the American Physiological Society.

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January 1, 2016; volume 310, issue 1

The below Table of Contents is available online at: http://ajpheart.physiology.org/content/current

Editorial Focus

Postconditioning of ischemic heart by intermittent ventricular pacing at the beginning of reperfusion: novel mechanisms and potential utilities ininterventional cardiology settingsFeiyan Yang, Lei XiJanuary 1, 2016 : H1-H3

DOI: 10.1152/ajpheart.00835.2015

CALL FOR PAPERS | Mechanisms of Diastolic Dysfunction in Cardiovascular Disease

Spectral transfer function analysis of respiratory hemodynamic fluctuations predicts end-diastolic stiffness in preserved ejection fraction heart failure

Mahmoud Abdellatif, Sara Leite, Mohamed Alaa, José Oliveira-Pinto, Marta Tavares-Silva, Dulce Fontoura, Inês Falcão-Pires, Adelino F. Leite-Moreira, André P. LourençoJanuary 1, 2016 : H4-H13

DOI: 10.1152/ajpheart.00399.2015

We demonstrate that spectral transfer function analysis of gain between end-diastolic pressure and stroke volume is impaired in experimentalpreserved ejection fraction heart failure (HFpEF), validating previous exploratory clinical data. We further demonstrate a clear relation to end-diastolic stiffness, which suggests it may be used as a screening/diagnostic tool in HFpEF.

Myocardial steatosis as a possible mechanistic link between diastolic dysfunction and coronary microvascular dysfunction in womenJanet Wei, Michael D. Nelson, Edward W. Szczepaniak, Laura Smith, Puja K. Mehta, Louise E. J. Thomson, Daniel S. Berman, Debiao Li, C.Noel Bairey Merz, Lidia S. SzczepaniakJanuary 1, 2016 : H14-H19

DOI: 10.1152/ajpheart.00612.2015

Heart failure with preserved ejection fraction (HFpEF) is highly prevalent in women but poorly understood. Mechanistic understanding is critical tothe development of HFpEF management strategies and guidelines. In this article, we present magnetic resonance spectroscopy data that identifycardiomyocyte fat accumulation as a potential novel mechanistic pathway.

CALL FOR PAPERS | Cardiac Regeneration and Repair: Mechanisms and Therapy

Early upregulation of myocardial CXCR4 expression is critical for dimethyloxalylglycine-induced cardiac improvement in acute myocardialinfarctionMari Mayorga, Matthew Kiedrowski, Patricia Shamhart, Farhad Forudi, Kristal Weber, William M. Chilian, Marc S. Penn, Feng DongJanuary 1, 2016 : H20-H28

DOI: 10.1152/ajpheart.00449.2015

This is the first study that demonstrated that the benefit of dimethyloxalylglycine treatment or upregulation of HIF-1α in the heart requires cardiacCXCR4 expression. Our results further indicate that engagement of the SDF-1:CXCR4 axis through the early upregulation of CM-CXCR4 is astrategy for improving cardiac repair after myocardial infarction.

CALL FOR PAPERS | Autophagy in the Cardiovascular System

The cardioprotective compound cloxyquin uncouples mitochondria and induces autophagyJimmy Zhang, Sergiy M. Nadtochiy, William R. Urciuoli, Paul S. BrookesJanuary 1, 2016 : H29-H38

DOI: 10.1152/ajpheart.00926.2014

The cardioprotective compound cloxyquin uncoupled mitochondria and induced autophagy. Cardioprotection was blocked by an autophagyinhibitor, and the cardioprotective effects of cloxyquin were confirmed in vivo. Together these findings demonstrate a link between mitochondrialuncoupling and autophagy in the heart and suggest that cloxyquin is a useful tool to study this.

Vascular Biology and Microcirculation

Endothelial PPAR-γ provides vascular protection from IL-1β-induced oxidative stressMasashi Mukohda, Madeliene Stump, Pimonrat Ketsawatsomkron, Chunyan Hu, Frederick W. Quelle, Curt D. SigmundJanuary 1, 2016 : H39-H48

DOI: 10.1152/ajpheart.00490.2015

Peroxisome proliferator-activated receptor (PPAR)-γ is anti-inflammatory, and we show here that treatment of the aorta with IL-1β activates NF-κBand NF-κB-dependent transcription. We show that the protective actions of PPAR-γ activation, induced by either rosiglitazone or overexpression ofPPAR-γ in the endothelium, occurs independently of NF-κB activity, by reducing oxidative stress and preserving the phospho-endothelial nitricoxide synthase-to-endothelial nitric oxide synthase ratio.

Endothelial cell activation by hemodynamic shear stress derived from arteriovenous fistula for hemodialysis accessMarco Franzoni, Irene Cattaneo, Lorena Longaretti, Marina Figliuzzi, Bogdan Ene-Iordache, Andrea RemuzziJanuary 1, 2016 : H49-H59

DOI: 10.1152/ajpheart.00098.2015

The present investigation demonstrates that, in regions near the anastomosis of arteriovenous fistula for hemodialysis access, reciprocating flowsacting on endothelial cells induce important changes in gene expression, cytokine production and cytoskeleton organization. These changes may be

responsible for intimal hyperplasia and ultimately for vascular access failure.

Lymph flow pattern in pleural diaphragmatic lymphatics during intrinsic and extrinsic isotonic contractionAndrea Moriondo, Eleonora Solari, Cristiana Marcozzi, Daniela NegriniJanuary 1, 2016 : H60-H70

DOI: 10.1152/ajpheart.00640.2015

In diaphragmatic lymphatics, flow velocity and lymph flow were more than two order of magnitude greater during contraction of diaphragmaticskeletal muscle than during spontaneous contraction of lymphatic smooth muscles, suggesting a marginal role of the latter in setting lymph flow inrhythmically moving, thoracic tissues.

MPST but not CSE is the primary regulator of hydrogen sulfide production and function in the coronary arteryMaggie M. Kuo, Dae Hee Kim, Sandeep Jandu, Yehudit Bergman, Siqi Tan, Huilei Wang, Deepesh R. Pandey, Theodore P. Abraham, ArtinA. Shoukas, Dan E. Berkowitz, Lakshmi SanthanamJanuary 1, 2016 : H71-H79

DOI: 10.1152/ajpheart.00574.2014

MPST rather than CSE generates H2S in coronary artery, mediating its effects through direct modulation of NO. This has important implications forH2S-based therapy in healthy and diseased coronary arteries.

Energetics and Metabolism

2-Deoxyadenosine triphosphate restores the contractile function of cardiac myofibril from adult dogs with naturally occurring dilatedcardiomyopathyYuanhua Cheng, Kaley A. Hogarth, M. Lynne O'Sullivan, Michael Regnier, W. Glen PyleJanuary 1, 2016 : H80-H91

DOI: 10.1152/ajpheart.00530.2015

1) First report to characterize and define the contractile kinetics and defects associated with naturally occurring dilated cardiomyopathy (DCM) indogs. 2) Novel findings that dATP is able to reverse the contractile defects associated with naturally occurring canine DCM.

Signaling and Stress Response

Heterozygous deletion of sarcolipin maintains normal cardiac functionDaisuke Shimura, Yoichiro Kusakari, Tetsuo Sasano, Yasuhiro Nakashima, Gaku Nakai, QibinJiao, Meihua Jin, Tomohiro Yokota, Yoshihiro Ishikawa, Atsushi Nakano, Nobuhito Goda, Susumu MinamisawaJanuary 1, 2016 : H92-H103

DOI: 10.1152/ajpheart.00411.2015

Sarcolipin (SLN) heterozygous deletion showed a normal cardiac phenotype at baseline and may have protective effects against chronic β-adrenergic stimulilation-induced cardiac impairment. Because our SLN knockout mice were created by a knockin of Cre recombinase into theendogenous Sln locus, SLN-Cre knockin mice are appropriate for atrium-specific gene targeting.

Integrative Cardiovascular Physiology and Pathophysiology

Endogenous angiotensin-(1-7)/Mas receptor/NO pathway mediates the cardioprotective effects of pacing postconditioningAla'a Abwainy, Fawzi Babiker, Saghir Akhtar, Ibrahim F. BenterJanuary 1, 2016 : H104-H112

DOI: 10.1152/ajpheart.00121.2015

Hearts can be protected from ischemic injury by pacing postconditioning. Using an isolated heart model of ischemia-reperfusion injury, we providenovel insights into the cardioprotective mechanisms of pacing postconditioning in that they involve the Mas receptor and endothelial nitric oxidesynthase. The data suggest a potential therapeutic role for ANG-(1–7) in cardiac ischemic injury.

Determinants of kinetic energy of blood flow in the four-chambered heart in athletes and sedentary controlsK. Steding-Ehrenborg, P. M. Arvidsson, J. Töger, M. Rydberg, E. Heiberg, M. Carlsson, H. ArhedenJanuary 1, 2016 : H113-H122

DOI: 10.1152/ajpheart.00544.2015

In line with the different filling mechanisms for the ventricles, we show that left ventricular (LV) mass is a determinant of kinetic energy (KE) for LVfilling, whereas for the right ventricle, end-diastolic volume, i.e., blood mass, determines KE. Furthermore, 70% of diastolic KE is found inside the

LV diastolic vortex.

Exaggerated sympathetic and cardiovascular responses to stimulation of the mesencephalic locomotor region in spontaneously hypertensive ratsNan Liang, Jere H. Mitchell, Scott A. Smith, Masaki MizunoJanuary 1, 2016 : H123-H131

DOI: 10.1152/ajpheart.00479.2015

The data suggest that the exaggerated cardiovascular and sympathetic responses to physical activity characteristic of hypertension are mediated, inpart, by augmentations in central command function. These findings identify the central command pathway as a potential target for the treatment ofexercise-induced circulatory hyperexcitability in hypertensive individuals.

Letters to the Editor

Letter to the editor: Applying the blood flow restriction pressure: the elephant in the roomMatthew B. Jessee, Samuel L. Buckner, J. Grant Mouser, Kevin T. Mattocks, Jeremy P. LoennekeJanuary 1, 2016 : H132-H133

DOI: 10.1152/ajpheart.00820.2015

Reply to “Letter to the editor: Applying the blood flow restriction pressure: the elephant in the room”Marty D. Spranger, Abhinav C. Krishnan, Phillip D. Levy, Donal S. O'Leary, Scott A. SmithJanuary 1, 2016 : H134-H135

DOI: 10.1152/ajpheart.00878.2015

Copyright © 2016 by the American Physiological Society.

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January 1, 2016; volume 310, issue 1

The below Table of Contents is available online at: http://ajplung.physiology.org/content/current

Rapid Report

Systemic interleukin-2 administration improves lung function and modulates chorioamnionitis-induced pulmonary inflammation in the ovine fetusMonique G. M. Willems, Daan R. M. G. Ophelders, Maria Nikiforou, Reint K. Jellema, Anke Butz, Tammo Delhaas, Boris W. Kramer, Tim G. A.M. WolfsJanuary 1, 2016 : L1-L7

DOI: 10.1152/ajplung.00289.2015

CALL FOR PAPERS | Bioengineering the Lung: Molecules, Materials, Matrix, Morphology, and Mechanics

Induction and regulation of murine emphysema by elastin peptidesMehdi Sellami, Aïda Meghraoui-Kheddar, Christine Terryn, Caroline Fichel, Nicole Bouland, Marie-Daniele Diebold, Moncef Guenounou, Stéphanie Héry-Huynh, Richard Le NaourJanuary 1, 2016 : L8-L23

DOI: 10.1152/ajplung.00068.2015

CALL FOR PAPERS | Biomarkers in Lung Diseases: from Pathogenesis to Prediction to New Therapies

A systemic defect in Toll-like receptor 4 signaling increases lipopolysaccharide-induced suppression of IL-2-dependent T-cell proliferation in COPDJürgen Knobloch, Sarah-Jane Chikosi, Sarah Yanik, Jan Rupp, David Jungck, Andrea KochJanuary 1, 2016 : L24-L39

DOI: 10.1152/ajplung.00367.2014

Decreased endothelial nitric oxide synthase expression and function contribute to impaired mitochondrial biogenesis and oxidative stress in fetallambs with persistent pulmonary hypertensionAdeleye J. Afolayan, Annie Eis, Maxwell Alexander, Teresa Michalkiewicz, Ru-Jeng Teng, Satyan Lakshminrusimha, Girija G. KonduriJanuary 1, 2016 : L40-L49

DOI: 10.1152/ajplung.00392.2014

CALL FOR PAPERS | Ion Channels and Transporters in Lung Function and Disease

Carvedilol binding to β2-adrenergic receptors inhibits CFTR-dependent anion secretion in airway epithelial cellsElizabeth R. Peitzman, Nathan A. Zaidman, Peter J. Maniak, Scott M. O'GradyJanuary 1, 2016 : L50-L58

DOI: 10.1152/ajplung.00296.2015

The dual phosphodiesterase 3 and 4 inhibitor RPL554 stimulates CFTR and ciliary beating in primary cultures of bronchial epitheliaMark J. Turner, Elizabeth Matthes, Arnaud Billet, Amy J. Ferguson, David Y. Thomas, Scott H. Randell, Lawrence E. Ostrowski, Kathy Abbott-Banner, John W. HanrahanJanuary 1, 2016 : L59-L70

DOI: 10.1152/ajplung.00324.2015

Articles

N-cadherin coordinates AMP kinase-mediated lung vascular repairMing-Yuan Jian, Yanping Liu, Qian Li, Paul Wolkowicz, Mikhail Alexeyev, Jaroslaw Zmijewski, Judy CreightonJanuary 1, 2016 : L71-L85

DOI: 10.1152/ajplung.00227.2015

CaMKII inhibition in type II pneumocytes protects from bleomycin-induced pulmonary fibrosis by preventing Ca2+-dependent apoptosisChristopher J. Winters, Olha Koval, Shubha Murthy, Chantal Allamargot, Sara C. Sebag, John D. Paschke, Omar A. Jaffer, A. Brent Carter, IsabellaM. GrumbachJanuary 1, 2016 : L86-L94

DOI: 10.1152/ajplung.00132.2015

Dendritic cells inversely regulate airway inflammation in cigarette smoke-exposed miceMasoumeh Ezzati Givi, Peyman Akbari, Louis Boon, Vladimir S. Puzovic, Gillina F. G. Bezemer, Fabio L. M. Ricciardolo, Gert Folkerts, FrankA. Redegeld, Esmaeil MortazJanuary 1, 2016 : L95-L102

DOI: 10.1152/ajplung.00251.2014

Copyright © 2016 by the American Physiological Society.

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January 1, 2016; volume 310, issue 1

The below Table of Contents is available online at: http://ajpregu.physiology.org/content/current

Review

Reactive oxygen species: players in the cardiovascular effects of testosterone

Rita C. Tostes, Fernando S. Carneiro, Maria Helena C. Carvalho, Jane F. ReckelhoffJanuary 1, 2016 : R1-R14

DOI: 10.1152/ajpregu.00392.2014

CALL FOR PAPERS | Central Control of Fluid and Electrolyte Homeostasis

Water deprivation-partial rehydration induces sensitization of sodium appetite and alteration of hypothalamic transcriptsDaniela T. B. Pereira-Derderian, Regina C. Vendramini, José V. Menani, Silvana Chiavegatto, Laurival A. De LucaJanuary 1, 2016 : R15-R23

DOI: 10.1152/ajpregu.00501.2014

Translational Physiology

Candida glabrata binds to glycosylated and lectinic receptors on the coronary endothelial luminal membrane and inhibits flow sense and cardiacresponses to agonistsDavid Torres-Tirado, Maureen Knabb, Irene Castaño, Araceli Patrón-Soberano, Alejandro De Las Peñas, Rafael RubioJanuary 1, 2016 : R24-R32

DOI: 10.1152/ajpregu.00229.2014

Neural Control

Genetic identity of thermosensory relay neurons in the lateral parabrachial nucleusJoel C. Geerling, Minjee Kim, Carrie E. Mahoney, Stephen B. G. Abbott, Lindsay J. Agostinelli, Alastair S. Garfield, Michael J. Krashes, BradfordB. Lowell, Thomas E. ScammellJanuary 1, 2016 : R41-R54

DOI: 10.1152/ajpregu.00094.2015

Orexin signaling is necessary for hypoglycemia-induced prevention of conditioned place preferenceOleg Otlivanchik, Nicole M. Sanders, Ambrose Dunn-Meynell, Barry E. LevinJanuary 1, 2016 : R66-R73

DOI: 10.1152/ajpregu.00066.2015

Role of endothelin-1 in mediating changes in cardiac sympathetic nerve activity in heart failureYonis Abukar, Clive N. May, Rohit RamchandraJanuary 1, 2016 : R94-R99

DOI: 10.1152/ajpregu.00205.2015

Fluid and Electrolyte Homeostasis

Genetic identity of thermosensory relay neurons in the lateral parabrachial nucleusJoel C. Geerling, Minjee Kim, Carrie E. Mahoney, Stephen B. G. Abbott, Lindsay J. Agostinelli, Alastair S. Garfield, Michael J. Krashes, BradfordB. Lowell, Thomas E. ScammellJanuary 1, 2016 : R41-R54

DOI: 10.1152/ajpregu.00094.2015

Postural influence on intracranial and cerebral perfusion pressure in ambulatory neurosurgical patientsL. G. Petersen, J. C. G. Petersen, M. Andresen, N. H. Secher, M. JuhlerJanuary 1, 2016 : R100-R104

DOI: 10.1152/ajpregu.00302.2015

Obesity, Diabetes and Energy Homeostasis

Adipogenic role of alternatively activated macrophages in β-adrenergic remodeling of white adipose tissueYun-Hee Lee, Sang-Nam Kim, Hyun-Jung Kwon, Krishna Rao Maddipati, James G. GrannemanJanuary 1, 2016 : R55-R65

DOI: 10.1152/ajpregu.00355.2015

Orexin signaling is necessary for hypoglycemia-induced prevention of conditioned place preferenceOleg Otlivanchik, Nicole M. Sanders, Ambrose Dunn-Meynell, Barry E. LevinJanuary 1, 2016 : R66-R73

DOI: 10.1152/ajpregu.00066.2015

Hepatic fatty acid biosynthesis is more responsive to protein than carbohydrate in rainbow trout during acute stimulationsWeiwei Dai, Stéphane Panserat, Sadasivam Kaushik, Frédéric Terrier, Elisabeth Plagnes-Juan, Iban Seiliez, Sandrine Skiba-CassyJanuary 1, 2016 : R74-R86

DOI: 10.1152/ajpregu.00281.2015

Activation of placental insulin and mTOR signaling in a mouse model of maternal obesity associated with fetal overgrowthFredrick J. Rosario, Theresa L. Powell, Thomas JanssonJanuary 1, 2016 : R87-R93

DOI: 10.1152/ajpregu.00356.2015

Cardiovascular and Renal Integration

Role of endothelin-1 in mediating changes in cardiac sympathetic nerve activity in heart failureYonis Abukar, Clive N. May, Rohit RamchandraJanuary 1, 2016 : R94-R99

DOI: 10.1152/ajpregu.00205.2015

Postural influence on intracranial and cerebral perfusion pressure in ambulatory neurosurgical patientsL. G. Petersen, J. C. G. Petersen, M. Andresen, N. H. Secher, M. JuhlerJanuary 1, 2016 : R100-R104

DOI: 10.1152/ajpregu.00302.2015

Hormones, Reproduction and Development

ZnT4 (SLC30A4)-null (“lethal milk”) mice have defects in mammary gland secretion and hallmarks of precocious involution during lactationNicholas H. McCormick, Sooyeon Lee, Stephen R. Hennigar, Shannon L. KelleherJanuary 1, 2016 : R33-R40

DOI: 10.1152/ajpregu.00315.2014

Copyright © 2016 by the American Physiological Society.

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January 1, 2016; volume 310, issue 1

The below Table of Contents is available online at: http://ajprenal.physiology.org/content/current

Reviews

Discerning the role of mechanosensors in regulating proximal tubule functionVenkatesan Raghavan, Ora A. WeiszJanuary 1, 2016 : F1-F5

DOI: 10.1152/ajprenal.00373.2015

Mesenchymal stem cells and chronic renal artery stenosisElizabeth B. Oliveira-Sales, Mirian A. BoimJanuary 1, 2016 : F6-F9

DOI: 10.1152/ajprenal.00341.2015

Mini-review: regulation of the renal NaCl cotransporter by hormonesLorena Rojas-Vega, Gerardo GambaJanuary 1, 2016 : F10-F14

DOI: 10.1152/ajprenal.00354.2015

CALL FOR PAPERS | Transport Proteins as Regulators of Blood Pressure Homeostasis

Cell-specific regulation of L-WNK1 by dietary K+Tennille N. Webb, Rolando Carrisoza-Gaytan, Nicolas Montalbetti, Anna Rued, Ankita Roy, Alexandra M. Socovich, Arohan R. Subramanya, LisaM. Satlin, Thomas R. Kleyman, Marcelo D.CarattinoJanuary 1, 2016 : F15-F26

DOI: 10.1152/ajprenal.00226.2015

CALL FOR PAPERS | Mechanism and Treatment of Renal Fibrosis

Erythropoietin protects the tubular basement membrane by promoting the bone marrow to release extracellular vesicles containing tPA-targetingmiR-144Yang Zhou, Li Fang, Yanting Yu, Jing Niu, Lei Jiang, Hongdi Cao, Qi Sun, Ke Zen, Chunsun Dai, Junwei YangJanuary 1, 2016 : F27-F40

DOI: 10.1152/ajprenal.00303.2015

Editorial Focus

MRI shines (radiofrequency) light on kidney physiologyKevin M. BennettJanuary 1, 2016 : F41-F42

DOI: 10.1152/ajprenal.00462.2015

Articles

Renal denervation attenuates NADPH oxidase-mediated oxidative stress and hypertension in rats with hydronephrosisMaria Peleli, Ammar Al-Mashhadi, Ting Yang, Erik Larsson, Nils Wåhlin, Boye L. Jensen, A. Erik G. Persson, Mattias CarlströmJanuary 1, 2016 : F43-F56

DOI: 10.1152/ajprenal.00345.2015

The multidrug transporter MATE1 sequesters OCs within an intracellular compartment that has no influence on OC secretion in renal proximaltubulesL. J. Martínez-Guerrero, K. K. Evans, W. H. Dantzler, S. H. WrightJanuary 1, 2016 : F57-F67

DOI: 10.1152/ajprenal.00318.2015

Role of FQQI motif in the internalization, trafficking, and signaling of guanylyl-cyclase/natriuretic peptide receptor-A in cultured murine mesangialcellsIndra Mani, Renu Garg, Kailash N. PandeyJanuary 1, 2016 : F68-F84

DOI: 10.1152/ajprenal.00205.2015

NKT cell modulates NAFLD potentiation of metabolic oxidative stress-induced mesangial cell activation and proximal tubular toxicityFiras Alhasson, Diptadip Dattaroy, Suvarthi Das, Varun Chandrashekaran, Ratanesh Kumar Seth, Rick G. Schnellmann, Saurabh ChatterjeeJanuary 1, 2016 : F85-F101

DOI: 10.1152/ajprenal.00243.2015

Bicarbonate-sensitive calcification and lifespan of klotho-deficient miceChristina B. Leibrock, Jakob Voelkl, Ursula Kohlhofer, Leticia Quintanilla-Martinez, Makoto Kuro-o, Florian LangJanuary 1, 2016 : F102-F108

DOI: 10.1152/ajprenal.00037.2015

Copyright © 2016 by the American Physiological Society.

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January 1, 2016; volume 120, issue 1

The below Table of Contents is available online at: http://jap.physiology.org/content/current

Review

Physical activity-induced remodeling of vasculature in skeletal muscle: role in treatment of type 2 diabetesM. Harold LaughlinJanuary 1, 2016 : 1-16

DOI: 10.1152/japplphysiol.00789.2015

Synthesis Review

The role of morphology in mathematical models of placental gas exchangeA. S. Serov, C. Salafia, D. S. Grebenkov, M. FilocheJanuary 1, 2016 : 17-28

DOI: 10.1152/japplphysiol.00543.2015

Articles

Eccentric contraction-induced myofiber growth in tumor-bearing miceJustin P. Hardee, Joshua E. Mangum, Song Gao, Shuichi Sato, Kimbell L. Hetzler, Melissa J. Puppa, Dennis K. Fix, James A. CarsonJanuary 1, 2016 : 29-37

DOI: 10.1152/japplphysiol.00416.2015

Onset of alveolar recirculation in the developing lungs and its consequence on nanoparticle deposition in the pulmonary acinusFrank S. Henry, Akira TsudaJanuary 1, 2016 : 38-54

DOI: 10.1152/japplphysiol.01161.2014

Is the metabolic cost of walking higher in people with diabetes?M. Petrovic, K. Deschamps, S. M. Verschueren, F. L. Bowling, C. N. Maganaris, A. J. M. Boulton, N. D. ReevesJanuary 1, 2016 : 55-62

DOI: 10.1152/japplphysiol.00413.2015

Triceps surae muscle-tendon properties in older endurance- and sprint-trained athletesLauri Stenroth, Neil J. Cronin, Jussi Peltonen, Marko T. Korhonen, Sarianna Sipilä, Taija FinniJanuary 1, 2016 : 63-69

DOI: 10.1152/japplphysiol.00511.2015

No reserve in isokinetic cycling power at intolerance during ramp incremental exercise in endurance-trained menCarrie Ferguson, Lindsey A. Wylde, Alan P. Benson, Daniel T. Cannon, Harry B. RossiterJanuary 1, 2016 : 70-77

DOI: 10.1152/japplphysiol.00662.2015

The effect of leptin replacement on sleep-disordered breathing in the leptin-deficientob/ob mouse

H. Pho, A. B. Hernandez, R. S. Arias, E. B. Leitner, S. Van Kooten, J. P. Kirkness, H. Schneider, P. L. Smith, V. Y. Polotsky, A. R. SchwartzJanuary 1, 2016 : 78-86

DOI: 10.1152/japplphysiol.00494.2015

Impact of 5-aminolevulinic acid with iron supplementation on exercise efficiency and home-based walking training achievement in older womenShizue Masuki, Atsumi Morita, Yoshi-ichiro Kamijo, Shigeki Ikegawa, Yufuko Kataoka, Yu Ogawa,Eri Sumiyoshi, Kiwamu Takahashi, Tohru Tanaka, Motowo Nakajima, Hiroshi NoseJanuary 1, 2016 : 87-96

DOI: 10.1152/japplphysiol.00582.2015

OPEN ACCESS ARTICLE

Copyright © 2016 by the American Physiological Society.

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December 2015; volume 114, issue 6

Neuro Forum

Cortical specificity in neurovascular couplingNadia Aleyna ScottDecember 1, 2015 : 3031-3032

DOI: 10.1152/jn.00915.2014

Insight into motor control and motor impairment from stroke and beta oscillationsRamina Adam, Silvia Isabella, Jason L. ChanDecember 1, 2015 : 3033-3035

DOI: 10.1152/jn.00098.2015

Feature-based and object-based attention orientation during short-term memory maintenanceYixuan KuDecember 1, 2015 : 3036-3038

DOI: 10.1152/jn.00342.2015

CALL FOR PAPERS | Auditory System Plasticity

Bimodal stimulus timing-dependent plasticity in primary auditory cortex is altered after noise exposure with and without tinnitusGregory J. Basura, Seth D. Koehler, Susan E. ShoreDecember 1, 2015 : 3064-3075

DOI: 10.1152/jn.00319.2015

CALL FOR PAPERS | Comparative Approaches in Neurobiology

Cell swelling increases the severity of spreading depression in Locusta migratoriaKristin E. Spong, Brittany Chin, Kelsey L. M. Witiuk, R. Meldrum RobertsonDecember 1, 2015 : 3111-3120

DOI: 10.1152/jn.00804.2015

CALL FOR PAPERS | Decision Making: Neural Mechanisms

Insights into decision making using choice probabilityTrinity B. Crapse, Michele A. BassoDecember 1, 2015 : 3039-3049

DOI: 10.1152/jn.00335.2015

CALL FOR PAPERS | Neurophysiology of Tactile Perception: A Tribute to Steven Hsiao

Genetically identified spinal interneurons integrating tactile afferents for motor controlTuan V. Bui, Nicolas Stifani, Izabela Panek, Carl FarahDecember 1, 2015 : 3050-3063

DOI: 10.1152/jn.00522.2015

Tactile orientation perception: an ideal observer analysis of human psychophysical performance in relation to macaque area 3b receptive fieldsRyan M. Peters, Phillip Staibano, Daniel GoldreichDecember 1, 2015 : 3076-3096

DOI: 10.1152/jn.00631.2015

Processing time of addition or withdrawal of single or combined balance-stabilizing haptic and visual informationJean-Louis Honeine, Oscar Crisafulli, Stefania Sozzi, Marco SchieppatiDecember 1, 2015 : 3097-3110

DOI: 10.1152/jn.00618.2015

Touch automatically upregulates motor readiness in humansFreek van Ede, Tobias Winner, Eric MarisDecember 1, 2015 : 3121-3130

DOI: 10.1152/jn.00504.2015

The role of vibration in tactile speed perceptionChris J. Dallmann, Marc O. Ernst, Alessandro MoscatelliDecember 1, 2015 : 3131-3139

DOI: 10.1152/jn.00621.2015

Cellular and Molecular Properties of Neurons

Corticotropin-releasing factor increases Purkinje neuron excitability by modulating sodium, potassium, and Ih currentsAvraham M. Libster, Ben Title, Yosef YaromDecember 1, 2015 : 3339-3350

DOI: 10.1152/jn.00745.2015

Control of Movement

Intermanual transfer characteristics of dynamic learning: direction, coordinate frame, and consolidation of interlimb generalizationChristian Stockinger, Benjamin Thürer, Anne Focke, Thorsten SteinDecember 1, 2015 : 3166-3176

DOI: 10.1152/jn.00727.2015

Integrating multiple sensory systems to modulate neural networks controlling postureI. Lavrov, Y. Gerasimenko, J. Burdick, H. Zhong, R. R. Roy, V. R. EdgertonDecember 1, 2015 : 3306-3314

DOI: 10.1152/jn.00583.2015

Goal-dependent modulation of the long-latency stretch response at the shoulder, elbow, and wristJeffrey Weiler, Paul L. Gribble, J. Andrew PruszynskiDecember 1, 2015 : 3242-3254

DOI: 10.1152/jn.00702.2015

Split-belt walking adaptation recalibrates sensorimotor estimates of leg speed but not position or force

Alejandro Vazquez, Matthew A. Statton, Stefanie A. Busgang, Amy J. BastianDecember 1, 2015 : 3255-3267

DOI: 10.1152/jn.00302.2015

Spatiotemporal distribution of location and object effects in reach-to-grasp kinematicsAdam G. Rouse, Marc H. SchieberDecember 1, 2015 : 3268-3282

DOI: 10.1152/jn.00686.2015

Muscle coordination limits efficiency and power output of human limb movement under a wide range of mechanical demandsOllie M. Blake, James M. WakelingDecember 1, 2015 : 3283-3295

DOI: 10.1152/jn.00765.2015

Long-term training modifies the modular structure and organization of walking balance controlAndrew Sawers, Jessica L. Allen, Lena H. TingDecember 1, 2015 : 3359-3373

DOI: 10.1152/jn.00758.2015

Voluntary reaction time and long-latency reflex modulationChristopher J. Forgaard, Ian M. Franks, Dana Maslovat, Laurence Chin, Romeo ChuaDecember 1, 2015 : 3386-3399

DOI: 10.1152/jn.00648.2015

Sensory Processing

Spike propagation through the dorsal root ganglia in an unmyelinated sensory neuron: a modeling studyDanielle Sundt, Nikita Gamper, David B. JaffeDecember 1, 2015 : 3140-3153

DOI: 10.1152/jn.00226.2015

OPEN ACCESS ARTICLE

The mammalian efferent vestibular system plays a crucial role in the high-frequency response and short-term adaptation of the vestibuloocular reflexPatrick P. Hübner, Serajul I. Khan, Americo A. MigliaccioDecember 1, 2015 : 3154-3165

DOI: 10.1152/jn.00307.2015

Functional differentiation of cholinergic and noradrenergic modulation in a biophysical model of olfactory bulb granule cellsGuoshi Li, Christiane Linster, Thomas A. ClelandDecember 1, 2015 : 3177-3200

DOI: 10.1152/jn.00324.2015

Dynamics of visual receptive fields in the macaque frontal eye fieldJ. Patrick Mayo, Amie R. DiTomasso, Marc A. Sommer, Matthew A. SmithDecember 1, 2015 : 3201-3210

DOI: 10.1152/jn.00746.2015

Parallel updating and weighting of multiple spatial maps for visual stability during whole body motionJ. J. Tramper, W. P. MedendorpDecember 1, 2015 : 3211-3219

DOI: 10.1152/jn.00576.2015

Changes in sensory reweighting of proprioceptive information during standing balance with age and diseaseJ. H. Pasma, D. Engelhart, A. B. Maier, A. C. Schouten, H. van der Kooij, C. G. M. MeskersDecember 1, 2015 : 3220-3233

DOI: 10.1152/jn.00414.2015

Contrast adaptation in the Limulus lateral eyeTchoudomira M. Valtcheva, Christopher L. PassagliaDecember 1, 2015 : 3234-3241

DOI: 10.1152/jn.00593.2015

Spatial phase sensitivity of complex cells in primary visual cortex depends on stimulus contrastH. Meffin, M. A. Hietanen, S. L. Cloherty, M. R. IbbotsonDecember 1, 2015 : 3326-3338

DOI: 10.1152/jn.00431.2015

Higher Neural Functions and Behavior

Efficient reinforcement learning of a reservoir network model of parametric working memory achieved with a cluster population winner-take-allreadout mechanismZhenbo Cheng, Zhidong Deng, Xiaolin Hu, Bo Zhang, Tianming YangDecember 1, 2015 : 3296-3305

DOI: 10.1152/jn.00378.2015

When brain damage “improves” perception: neglect patients can localize motion-shifted probes better than controlsStefania de Vito, Marine Lunven, Clémence Bourlon, Christophe Duret, Patrick Cavanagh, PaoloBartolomeoDecember 1, 2015 : 3351-3358

DOI: 10.1152/jn.00757.2015

Action-outcome relationships are represented differently by medial prefrontal and orbitofrontal cortex neurons during action executionNicholas W. Simon, Jesse Wood, Bita MoghaddamDecember 1, 2015 : 3374-3385

DOI: 10.1152/jn.00884.2015

Nervous System Pathophysiology

Emergence of dominant initiation sites for interictal spikes in rat neocortexDaniel Vitantonio, Weifeng Xu, Xinling Geng, Brian S. Wolff, Kentaroh Takagaki, Gholam K. Motamedi, Jian-young WuDecember 1, 2015 : 3315-3325

DOI: 10.1152/jn.00471.2014

Corrigendum

CorrigendumDecember 1, 2015 : 3400

DOI: 10.1152/jn.z9k-3452-corr.2015

Copyright © 2015 by the American Physiological Society.

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January 1, 2016; volume 48, issue 1

The below Table of Contents is available online at: http://physiolgenomics.physiology.org/content/current

Omics Technologies and Applications

Gene transcripts associated with muscle strength: a CHARGE meta-analysis of 7,781 personsL. C. Pilling, R. Joehanes, T. Kacprowski, M. Peters, R. Jansen, D. Karasik, D. P. Kiel, L. W.Harries, A. Teumer, J. Powell, D. Levy, H. Lin, K. Lunetta, P. Munson, S. Bandinelli, W. Henley, D.Hernandez, A. Singleton, T. Tanaka, G. van Grootheest, A. Hofman, A. G. Uitterlinden, R. Biffar, S.Gläser, G. Homuth, C. Malsch, U. Völker, B. Penninx, J. B. J. van Meurs, L. Ferrucci, T. Kocher, J. Murabito, D. MelzerJanuary 1, 2016 : 1-11

DOI: 10.1152/physiolgenomics.00054.2015

OPEN ACCESS ARTICLE

Genetic loci associated with nonobstructive coronary artery disease in Caucasian womenLiming Weng, Kent D. Taylor, Yii-Der Ida Chen, George Sopko, Sheryl F. Kelsey, C. Noel Bairey Merz, Carl J. Pepine, Virginia M. Miller, JeromeI. Rotter, Martha Gulati, Mark O. Goodarzi, Rhonda M. Cooper-DeHoffJanuary 1, 2016 : 12-20

DOI: 10.1152/physiolgenomics.00067.2015

Nutrient Gene Interaction

Protein-leucine ingestion activates a regenerative inflammo-myogenic transcriptome in skeletal muscle following intense endurance exerciseDavid S. Rowlands, Andre R. Nelson, Frederic Raymond, Sylviane Metairon, Robert Mansourian, Jim Clarke, Trent Stellingwerff, Stuart M. PhillipsJanuary 1, 2016 : 21-32

DOI: 10.1152/physiolgenomics.00068.2015

General Interest

Pharmacogenomics of estrogens on changes in carotid artery intima-medial thickness and coronary arterial calcification: Kronos Early EstrogenPrevention StudyVirginia M. Miller, Gregory D. Jenkins, Joanna M. Biernacka, John A. Heit, Gordon S. Huggins, Howard N. Hodis, Matthew J. Budoff, RogerioA. Lobo, Hugh S. Taylor, JoAnn E. Manson, Dennis M. Black, Frederick Naftolin, S. Mitchell Harman, Mariza de AndradeJanuary 1, 2016 : 33-41

DOI: 10.1152/physiolgenomics.00029.2015

Genomic and “Polyomic” Studies of Cardiovascular and Inflammatory Diseases

Telomere dynamics during aging in polygenic left ventricular hypertrophyFrancine Z. Marques, Scott A. Booth, Priscilla R. Prestes, Claire L. Curl, Lea M. D. Delbridge, Paul Lewandowski, Stephen B. Harrap, FadiJ. CharcharJanuary 1, 2016 : 42-49

DOI: 10.1152/physiolgenomics.00083.2015

Regulation of Gene Expression

Effects of combined progesterone and 17β-estradiol treatment on the transcriptome of cultured human myometrial smooth muscle cellsSreenath Chandran, Michael T. Cairns, Margaret O'Brien, Enda O'Connell, Kaveh Mashayekhi, Terry J. SmithJanuary 1, 2016 : 50-61

DOI: 10.1152/physiolgenomics.00021.2015

Genetic and Genomics Investigation of Structure and Function of the Kidney

Pappa2 is linked to salt-sensitive hypertension in Dahl S ratsAllen W. Cowley, Chun Yang, Vikash Kumar, Jozef Lazar, Howard Jacob, Aron M. Geurts,Pengyuan Liu, Alex Dayton, Theresa Kurth, Mingyu LiangJanuary 1, 2016 : 62-72

DOI: 10.1152/physiolgenomics.00097.2015

Copyright © 2016 by the American Physiological Society.

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January 2016; volume 31, issue 1

The below Table of Contents is available online at: http://physiologyonline.physiology.org/content/31/1

Editorial

The Landscape of PhysiologyDenis Noble, Julie Chan, Penny Hansen, Walter Boron, Peter WagnerDecember 11, 2015 : 2-4

DOI: 10.1152/physiol.00052.2015

Physiology in Perspective

Physiology in Perspective: Fulfilling the Promise of Tissue EngineeringGary C. SieckDecember 11, 2015 : 5-6

DOI: 10.1152/physiol.00053.2015

Reviews

Cardiovascular Tissue Engineering: Preclinical Validation to Bedside ApplicationCameron Best, Ekene Onwuka, Victoria Pepper, Malik Sams, Jake Breuer, Christopher BreuerDecember 11, 2015 : 7-15

DOI: 10.1152/physiol.00018.2015

Exosomal miRNAs in Heart DiseaseClaudio Iaconetti, Sabato Sorrentino, Salvatore De Rosa, Ciro IndolfiDecember 11, 2015 : 16-24

DOI: 10.1152/physiol.00029.2015

Novel Functions of Renin Precursors in Homeostasis and DiseaseR. Ariel Gomez, Maria Luisa S. Sequeira-LopezDecember 11, 2015 : 25-33

DOI: 10.1152/physiol.00039.2015

Pulsatility of Hypothalamo-Pituitary Hormones: A Challenge in QuantificationDaniel M. Keenan, Johannes D. VeldhuisDecember 16, 2015 : 34-50

DOI: 10.1152/physiol.00027.2015

The Chemistry of Cold: Mechanisms of Torpor Regulation in the Siberian HamsterCeyda Cubuk, Jonathan H. H. Bank, Annika HerwigDecember 16, 2015 : 51-59

DOI: 10.1152/physiol.00028.2015

The Role of Hydrogen Sulfide in Evolution and the Evolution of Hydrogen Sulfide in Metabolism and SignalingKenneth R. Olson, Karl D. StraubDecember 16, 2015 : 60-72

DOI: 10.1152/physiol.00024.2015

Copyright © 2016 by the American Physiological Society.

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December 2015; volume 39, issue 4

The below Table of Contents is available online at: http://advan.physiology.org/content/current

Editorial

Best Practices: a series of theory, evidence, and implementationDouglas Curran-EverettDecember 1, 2015 : 253

DOI: 10.1152/advan.00099.2015

A Personal View

Reform in teaching preclinical pathophysiologyYong-Yu Li, Kun Li, Hong Yao, Xiao-Juan Xu, Qiao-Lin CaiDecember 1, 2015 : 254-258

DOI: 10.1152/advan.00165.2014

A physiologist's view of homeostasisHarold Modell, William Cliff, Joel Michael, Jenny McFarland, Mary Pat Wenderoth, Ann WrightDecember 1, 2015 : 259-266

DOI: 10.1152/advan.00107.2015

Staying Current

Venous return and clinical hemodynamics: how the body works during acute hemorrhageTao Shen, Keith BakerDecember 1, 2015 : 267-271

DOI: 10.1152/advan.00050.2015

Best Practices

Harnessing the power of an online teaching community: connect, share, and collaborateMarsha Lakes Matyas, Dee U. SilverthornDecember 1, 2015 : 272-277

DOI: 10.1152/advan.00093.2015

How We Teach: Generalizable Education Research

Tracking undergraduate student achievement in a first-year physiology course using a cluster analysis approachS. J. Brown, S. White, N. PowerDecember 1, 2015 : 278-282

DOI: 10.1152/advan.00076.2015

Developing best practices teaching procedures for skinfold assessment: observational examination using the Think Aloud methodMichael E. Holmstrup, Steven D. Verba, Jeffrey S. LynnDecember 1, 2015 : 283-287

DOI: 10.1152/advan.00044.2015

Matters of taste: bridging molecular physiology and the humanitiesP. K. Rangachari, Usha RangachariDecember 1, 2015 : 288-294

DOI: 10.1152/advan.00092.2015

Establishing common course objectives for undergraduate exercise physiologyShawn R. SimonsonDecember 1, 2015 : 295-308

DOI: 10.1152/advan.00020.2015

Self-testing produces superior recall of both familiar and unfamiliar muscle informationJohn L. Dobson, Tracy Linderholm, Mary Beth YarbroughDecember 1, 2015 : 309-314

DOI: 10.1152/advan.00052.2015

Medical student service learning program teaches secondary students about career opportunities in health and medical fieldsKelly Karpa, Kavita Vakharia, Catherine A. Caruso, Colin Vechery, Lanette Sipple, Adrian WangDecember 1, 2015 : 315-319

DOI: 10.1152/advan.00124.2015

On being examined: do students and faculty agree?Andrew Perrella, Joshua Koenig, Henry Kwon, Stash Nastos, P. K. RangachariDecember 1, 2015 : 320-326

DOI: 10.1152/advan.00078.2015

Open problem-based instruction impacts understanding of physiological concepts differently in undergraduate studentsBrandon M. Franklin, Lin Xiang, Jason A. Collett, Megan K. Rhoads, Jeffrey L. OsbornDecember 1, 2015 : 327-334

DOI: 10.1152/advan.00082.2015

The effectiveness of concept mapping and retrieval practice as learning strategies in an undergraduate physiology courseJoseph Burdo, Laura O'DwyerDecember 1, 2015 : 335-340

DOI: 10.1152/advan.00041.2015

Evaluating the effectiveness of a laboratory-based professional development program for science educatorsMichael W. Amolins, Cathy M. Ezrailson, David A. Pearce, Amy J. Elliott, Peter F. VitielloDecember 1, 2015 : 341-351

DOI: 10.1152/advan.00088.2015

How We Teach: Classroom and Laboratory Research Projects

Redox signaling in skeletal muscle: role of aging and exerciseLi Li JiDecember 1, 2015 : 352-359

DOI: 10.1152/advan.00106.2014

Taking nanomedicine teaching into practice with atomic force microscopy and force spectroscopyFilomena A. Carvalho, Teresa Freitas, Nuno C. SantosDecember 1, 2015 : 360-366

DOI: 10.1152/advan.00119.2014

PowerPoint presentation in learning physiology by undergraduates with different learning stylesRoopa B. Ankad, Shashikala GV, Anita Herur, Manjula R, Surekharani Chinagudi, Shailaja PatilDecember 1, 2015 : 367-371

DOI: 10.1152/advan.00119.2015

Two-compartment model as a teaching tool for cholesterol homeostasisArtur Wrona, Joanna Balbus, Olga Hrydziuszko, Krystian KubicaDecember 1, 2015 : 372-377

DOI: 10.1152/advan.00141.2014

Correlation of self-assessment with attendance in an evidence-based medicine courseBeatriz U. RamirezDecember 1, 2015 : 378-382

DOI: 10.1152/advan.00072.2015

A multidisciplinary guided practical on type I diabetes engaging students in inquiry-based learningM. Mingueneau, A. Chaix, N. Scotti, J. Chaix, A. Reynders, C. Hammond, J. ThimonierDecember 1, 2015 : 383-391

DOI: 10.1152/advan.00045.2015

Using ultrasound to teach medical students cardiac physiologyFloyd E. Bell, L. Britt Wilson, Richard A. HoppmannDecember 1, 2015 : 392-396

DOI: 10.1152/advan.00123.2015

Starting physiology: bioelectrogenesisVander BaptistaDecember 1, 2015 : 397-404

DOI: 10.1152/advan.00051.2015

Sourcebook of Laboratory Activities in Physiology

Observing and understanding arterial and venous circulation differences in a physiology laboratory activityCaroline Altermann, Rithiele Gonçalves, Marcus Vinícius S. Lara, Ben-Hur S. Neves, Pâmela B. Mello-CarpesDecember 1, 2015 : 405-410

DOI: 10.1152/advan.00148.2014

Illuminations

Maximize a team-based learning gallery walk experience: herding cats is easier than you thinkDavid W. RodenbaughDecember 1, 2015 : 411-413

DOI: 10.1152/advan.00012.2015

Interactive intragroup tutorials: a need-based modification to enhance learning in physiologyTripti K. Srivastava, Lalitbhushan S. Waghmare, Arunita Jagzape, Vedprakash MishraDecember 1, 2015 : 414-415

DOI: 10.1152/advan.00055.2015

Using order of magnitude calculations to extend student comprehension of laboratory dataRob L. DeanDecember 1, 2015 : 416-418

DOI: 10.1152/advan.00118.2015

Physiology should be taught as science is practiced: an inquiry-based activity to investigate the “alkaline tide”Heidi L. Lujan, Stephen E. DiCarloDecember 1, 2015 : 419-420

DOI: 10.1152/advan.00089.2015

Copyright © 2015 by the American Physiological Society.

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January 1, 2016; volume 96, issue 1

The below Table of Contents is available online at: http://physrev.physiology.org/content/96/1

Reviews

Spermatogenesis: The Commitment to MeiosisMichael D. GriswoldNovember 4, 2015 : 1-17

DOI: 10.1152/physrev.00013.2015

Innate Immune Signaling Activated by MDR Bacteria in the AirwayDane Parker, Danielle Ahn, Taylor Cohen, Alice PrinceNovember 18, 2015 : 19-53

DOI: 10.1152/physrev.00009.2015

Male Reproductive Disorders and Fertility Trends: Influences of Environment and Genetic SusceptibilityNiels E. Skakkebaek, Ewa Rajpert-De Meyts, Germaine M. Buck Louis, Jorma Toppari, Anna-Maria Andersson, Michael L. Eisenberg, TinaKold Jensen, Niels Jørgensen, Shanna H. Swan, Katherine J. Sapra, Søren Ziebe, Lærke Priskorn, Anders JuulNovember 18, 2015 : 55-97

DOI: 10.1152/physrev.00017.2015

Are There Deleterious Cardiac Effects of Acute and Chronic Endurance Exercise?Thijs M. H. Eijsvogels, Antonio B. Fernandez, Paul D. ThompsonNovember 25, 2015 : 99-125

DOI: 10.1152/physrev.00029.2014

Egg Activation at Fertilization by a Soluble Sperm ProteinKarl Swann, F. Anthony LaiDecember 2, 2015 : 127-149

DOI: 10.1152/physrev.00012.2015

Taste of Fat: A Sixth Taste Modality?Philippe Besnard, Patricia Passilly-Degrace, Naim A. KhanDecember 2, 2015 : 151-176

DOI: 10.1152/physrev.00002.2015

KATP Channels in the Cardiovascular SystemMonique N. Foster, William A. CoetzeeDecember 9, 2015 : 177-252

DOI: 10.1152/physrev.00003.2015

Absence of Dystrophin Disrupts Skeletal Muscle Signaling: Roles of Ca2+, Reactive Oxygen Species, and Nitric Oxide in the Development ofMuscular DystrophyDavid G. Allen, Nicholas P. Whitehead, Stanley C. FroehnerDecember 16, 2015 : 253-305

DOI: 10.1152/physrev.00007.2015

Paradoxical Roles of Antioxidant Enzymes: Basic Mechanisms and Health ImplicationsXin Gen Lei, Jian-Hong Zhu, Wen-Hsing Cheng, Yongping Bao, Ye-Shih Ho, Amit R. Reddi, Arne Holmgren, Elias S. J. ArnérDecember 17, 2015 : 307-364

DOI: 10.1152/physrev.00010.2014

Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic EffectsSylvia Christakos, Puneet Dhawan, Annemieke Verstuyf, Lieve Verlinden, Geert CarmelietDecember 17, 2015 : 365-408

DOI: 10.1152/physrev.00014.2015

Copyright © 2016 by the American Physiological Society.

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December 2015; volume 3, issue 12

Original Research

The most sensitive inputs to cutaneous representing regions of primary somatosensory cortex do not change with behavioral trainingDavid T. Blake, Elsie SpingathDecember 3, 2015 : e12623

DOI: 10.14814/phy2.12623

Monkeys were trained in detection and discrimination tasks for up to 200 days. Changes in receptive field size and responsiveness were observed.The most sensitive inputs at each cortical location did not change with training.

Passive heating following the prematch warm-up in soccer: examining the time-course of changes in muscle temperature and contractile functionPaul W. M. Marshall, Rebecca Cross, Ric LovellDecember 3, 2015 : e12635

DOI: 10.14814/phy2.12635

Warm-ups are used before sport to improve performance, but sometimes there are enforced cool-down periods which could offset the benefits of awarm-up. This study showed that a soccer specific warm-up elevates muscle temperature and concomitant measures of voluntary and electricallyevoked contractile power. Use of passive heating during a cool down period did not effect any measures performed here, but values after cool-downwere still elevated from pre warm-up.

TNF causes changes in glomerular endothelial permeability and morphology through a Rho and myosin light chain kinase-dependent mechanismChang Xu, Xiaoyan Wu, Bradley K. Hack, Lihua Bao, Patrick N. CunninghamDecember 3, 2015 : e12636

DOI: 10.14814/phy2.12636

TNF is a key mediator of sepsis, and causes increased macromolecular permeability of renal endothelial cells. Here, we show that this TNF-inducedpermeability increase is dependent upon the Rho/MLCK pathway, associated with changes to the actin cytoskeleton. Through Rho and MLCK, TNFcauses separation between adjacent endothelial cells, degradation of their glycocalyx, and a possible increase in glomerular fenestrae.

Epoetin beta pegol alleviates oxidative stress and exacerbation of renal damage from iron deposition, thereby delaying CKD progression inprogressive glomerulonephritis ratsMichinori Hirata, Yoshihito Tashiro, Ken Aizawa, Ryohei Kawasaki, Yasushi Shimonaka, Koichi EndoDecember 3, 2015 : e12637

DOI: 10.14814/phy2.12637

This study indicates that a single dose of epoetin beta pegol (CERA) mitigates exacerbation of kidney damage, thereby delaying CKD progression ina glomerulonephritis rat model. CERA treatment suppressed oxidative stress, which would be involved in help regeneration of tubular cells. Inaddition, the alleviation by CERA of the exacerbation of kidney damage could be attributable to mitigation of tubular damage as a result of lowerediron deposition in the tubules.

Glicentin-related pancreatic polypeptide inhibits glucose-stimulated insulin secretion from the isolated pancreas of adult male ratsLynda Whiting, Kevin W. Stewart, Deborah L. Hay, Paul W. Harris, Yee S. Choong, Anthony R. J. Phillips, Margaret A. Brimble, Garth J.S. CooperDecember 3, 2015 : e12638

DOI: 10.14814/phy2.12638

Peptides derived from the glucagon gene Gcg, for example glucagon and glucagon-like peptide 1 (GLP-1), act as physiological regulators of fuelmetabolism and are thus of major interest in the pathogenesis of diseases such as type-2 diabetes and obesity. Glicentin-related pancreaticpolypeptide (GRPP) is another 30 amino-acid Gcg-derived peptide identified in human, mouse, rat and pig, whose potential glucoregulatory functionis largely unknown. We synthesized rat GRPP (rGRPP) and a closely related peptide, rat GRPP-like peptide (rGRPP-LP), investigated their actionsin the liver and pancreas of adult male rats and suggest that GRPP and GRPP-LP may be novel regulators of insulin secretion, acting through an as-yet undefined receptor.

Contributions of cardiac “funny” (f) channels and sarcoplasmic reticulum Ca2+ in regulating beating rate of mouse and guinea pig sinoatrial nodeIslom B. Nazarov, Christopher J. Schofield, Derek A. TerrarDecember 10, 2015 : e12561

DOI: 10.14814/phy2.12561

The aim of this study was to investigate the effects on spontaneous beating rate of mouse atrial preparations following selective block of cardiac“funny” (f) channels, I(f), and/or suppression of sarcoplasmic reticulum (SR) function in the absence and presence of β-adrenoceptor stimulation.The observations are consistent with a role for Ca2+ released from the SR in regulating I(f) and therefore beating rate of SA node preparations; thereappear to be additional contributions of SR-derived Ca2+ to effects of β-adrenoceptor stimulation on beating rate that are independent of I(f).

Heterozygous eNOS deficiency is associated with oxidative stress and endothelial dysfunction in diet-induced obesityM. Irfan Ali, Xunsheng Chen, Sean P. DidionDecember 10, 2015 : e12630

DOI: 10.14814/phy2.12630

The goals of this study were to determine mechanism(s) which serve to maintain normal endothelial function and those that promote endothelialdysfunction, such as that produced by a high fat diet, in heterozygous eNOS-deficient (eNOS+/−) mice. Our findings reveal that increased Ser1176-phosphorylation serves to promote normal endothelial responses in the absence of a single eNOS gene. In addition, heterozygous eNOS deficiencypredisposes blood vessels to developing endothelial dysfunction in response to a HFD. The impairment of endothelial function produced by a HFDin eNOS+/− mice appears to be mediated, in large part, by IL-6-induced increases in vascular superoxide.

Mouse ECG findings in aging, with conduction system affecting drugs and in cardiac pathologies: Development and validation of ECG analysisalgorithm in miceMari Merentie, Jukka A. Lipponen, Marja Hedman, Antti Hedman, Juha Hartikainen, Jenni Huusko, Line Lottonen-Raikaslehto, Viktor Parviainen, Svetlana Laidinen, Pasi A. Karjalainen, Seppo Ylä-HerttualaDecember 10, 2015 : e12639

DOI: 10.14814/phy2.12639

A new ECG analysis algorithm for analyzing mouse ECG was developed and found to be an accurate and feasible method. The ECG findingsassociated with aging, AMI and progressive LVH correlated well with the echocardiography findings and were found to resemble the ECG findingsseen in humans.

Increased susceptibility to bladder inflammation in smokers: targeting the PAF–PAF receptor interaction to manage inflammatory cell recruitmentJohn Marentette, Grant Kolar, Jane McHowatDecember 10, 2015 : e12641

DOI: 10.14814/phy2.12641

Inflammation in the bladder wall in response to 4 weeks of smoking (Panel B) is attenuated in the absence of iPLA2beta knockout mice (Panel D).

Intermittent neonatal hypoxia elicits the upregulation of inflammatory-related genes in adult male rats through long-lasting programming effectsAshley L. Gehrand, Mary L. Kaldunski, Eric D. Bruder, Shuang Jia, Martin J.Hessner, Hershel RaffDecember 10, 2015 : e12646

DOI: 10.14814/phy2.12646

We hypothesized that neonatal rat exposure to IH will subsequently result in a heightened inflammatory state in the adult. The analysis of plasmafrom adult rats previously exposed to neonatal 5% IH versus 10% IH resulted in 2579 significantly regulated genes including increased expression ofCxcl1, Cxcl2, Ccl3, Il1a, and Il1b. We conclude that neonatal exposure to intermittent hypoxia elicits a long-lasting programming effect in the adultresulting in an upregulation of inflammatory-related genes.

Changes in cerebral vascular reactivity and structure following prolonged exposure to high altitude in humansGlen E. Foster, Jodie Davies-Thompson, Paolo B. Dominelli, Manraj K. S.Heran, Joseph Donnelly, Gregory R. duManoir, PhilipN. Ainslie, AlexanderRauscher, A. William SheelDecember 10, 2015 : e12647

DOI: 10.14814/phy2.12647

We investigated the impact of high altitude exposure on regional cerebral vascular function and cerebral tissue volumes following return to thenormoxic environment. High altitude exposure led to improvements in regional cerebral reactivity depending upon the regional reactivity at baseline.In addition, grey matter volume was selectively reduced in otherwise healthy individuals.

Muscle damage and inflammation after eccentric exercise: can the repeated bout effect be removed?Nikos V. Margaritelis, Anastasios A. Theodorou, Vasilios Baltzopoulos, Constantinos N. Maganaris, Vassilis Paschalis, Antonios Kyparos, MichalisG.NikolaidisDecember 10, 2015 : e12648

DOI: 10.14814/phy2.12648

The alternating eccentric-concentric exercise scheme implemented in the present study, questioned the “dogma” of repeated bout effect by almostcompletely removing this adaptive phenomenon and perpetuating repeated episodes of muscle damage and inflammation. This novel paradigm hassuccessfully overcame the repeated bout effect, making experimentally feasible to investigate the potential role of exercise-induced muscle micro-damage as a stimulus for physiological and biochemical adaptations.

17(R)-resolvin D1 ameliorates bleomycin-induced pulmonary fibrosis in miceMasakiyo Yatomi, Takeshi Hisada, Tamotsu Ishizuka, Yasuhiko Koga, Akihiro Ono, Yosuke Kamide, Kaori Seki, Haruka Aoki-Saito, Hiroaki Tsurumaki, Noriaki Sunaga, Kyoichi Kaira, Kunio Dobashi, Masanobu Yamada, Fumikazu OkajimaDecember 10, 2015 : e12628

DOI: 10.14814/phy2.12628

Administration of 17(R)-RvD1 from the start of BLM treatment attenuated neutrophil alveolar infiltration, lung collagen content, and Interleukin-1β (IL-1β), transforming growth factor-β1 (TGF-β1), connective tissue growth factor (CTGF) and type I collagen mRNA expression, along withsubsequent reduction in histologically detectable fibrosis. The administration of 17(R)-RvD1 at the later fibrotic stage also improved the lung failure.These results suggest that 17(R)-RvD1 attenuates pulmonary fibrosis by promoting the resolution of neutrophilic inflammation and also providespulmonary restoration.

Blunted hypothalamic ghrelin signaling reduces diet intake in rats fed a low-protein diet in late pregnancyHaijun Gao, Stephanie Sisley, Chandra YallampalliDecember 10, 2015 : e12629

DOI: 10.14814/phy2.12629

Diet intake in response to intracerebraventricular injection of ghrelin was lower in pregnant rats fed a low protein diet compared to those fed controldiet. Meanwhile, phosphorylation of AMPK and ACC in the hypothalamus was also lower. These suggest that blunted ghrelin signaling in thehypothalamus of pregnant rats fed a LP diet leads to reduced diet intake.

Motor planning poststroke: impairment in vector-coded reach plansJohn-Ross Rizzo, Todd E. Hudson, Andrew Abdou, Ira G. Rashbaum, Ajax E. George, Preeti Raghavan, Michael S. LandyDecember 10, 2015 : e12650

DOI: 10.14814/phy2.12650

Participants with stroke and normal control participants made a series of center-out reaches on a tabletop. Here, average reach trajectories show thatreaches with the more affected limb in stroke are hypermetric.

Hypoxia reduces placental mTOR activation in a hypoxia-induced model of intrauterine growth restriction (IUGR)Rebecca Kimball, Montana Wayment, Daniel Merrill, Tyler Wahlquist, Paul R. Reynolds, Juan A. ArroyoDecember 10, 2015 : e12651

DOI: 10.14814/phy2.12651

Decreased placental mTOR is observed during hypoxia treatment leading to the development of IUGR.

Cigarette smoke represses the innate immune response to asbestosGilbert F. Morris, Svitlana Danchuk, Yu Wang, Beibei Xu, Roy J. Rando, Arnold R. Brody, Bin Shan, Deborah E. SullivanDecember 10, 2015 : e12652

DOI: 10.14814/phy2.12652

Subchronic exposure to cigarette smoke represses activation of the innate immune response to inhaled asbestos in a mouse model. The finding thatcigarette smoke represses the innate immune response to asbestos adds to a growing body of literature that cigarette smoke impairs immunesurveillance in the lung.

Influence of type 1 diabetes on basal and agonist-induced permeability of the blood–brain barrierWilliam G. Mayhan, Jasmine P. Scott, Denise M. ArrickDecember 10, 2015 : e12653

DOI: 10.14814/phy2.12653

The purpose of our study was to examine whether T1D altered basal and agonist-induced changes in permeability of the blood–brain barrier. Wefound that basal permeability was increased and agonist-induced changes in permeability were decreased in diabetic rats. We also found thatagonist-induced changes in diameter of cerebral arterioles were impaired by T1D. We suggest that T1D impairs two critical aspects of endothelialcell function, i.e., reactivity and permeability.

Induction of controlled hypoxic pregnancy in large mammalian speciesKirsty L. Brain, Beth J. Allison, Youguo Niu, Christine M. Cross, Nozomi Itani, Andrew D. Kane, Emilio A. Herrera, Dino A. GiussaniDecember 10, 2015 : e12614

DOI: 10.14814/phy2.12614

We introduce a technique for physiological research able to maintain chronically instrumented maternal and fetal sheep for prolonged periods ofgestation under significant and controlled isolated chronic hypoxia beyond levels that can be achieved by habitable high altitude. This model ofchronic hypoxia permits measurement of materno-fetal blood gases as the challenge is actually occurring. Chronic hypoxia of this magnitude andduration using this model recapitulates the significant asymmetric growth restriction, the pronounced cardiomyopathy, and the loss of endothelialfunction measured in offspring of high-risk pregnancy in humans, opening a new window of therapeutic research.

Exercise-conditioned plasma attenuates nuclear concentrations of DNA methyltransferase 3B in human peripheral blood mononuclear cellsSteven Horsburgh, Stephen Todryk, Christopher Toms, Colin N. Moran, Les AnsleyDecember 10, 2015 : e12621

DOI: 10.14814/phy2.12621

The study sought to elucidate the underlying mechanisms by which exercise-induced epigenetic modifications occur. Data show that DNMT3B, butnot DNMT3A, is attenuated when PBMCs were cultured in the presence of exercise-conditioned plasma. IL-6 may be one of many plasma proteinsinvolved in this complex process.

Vancomycin treatment and butyrate supplementation modulate gut microbe composition and severity of neointimal hyperplasia after arterial injuryKaren J. Ho, Liqun Xiong, Nathaniel J. Hubert, Anuradha Nadimpalli, Kelly Wun, Eugene B. Chang, Melina R. KibbeDecember 10, 2015 : e12627

DOI: 10.14814/phy2.12627

This report demonstrates that antibiotic modulation of gut microbial composition alters production of a microbe-derived metabolite, sodium butyrate,which then regulates the arterial remodeling response after balloon angioplasty in rats. One potential mechanism is inhibition of vascular smoothmuscle cell proliferation, migration, and cell cycle progression by butyrate.

Routine daily physical activity and glucose variations are strongly coupled in adults with T1DMSarah S. Farabi, David W. Carley, Ali Cinar, Lauretta QuinnDecember 10, 2015 : e12644

DOI: 10.14814/phy2.12644

The relationship between routine daily physical activity and glucose variations has not been systematically investigated in adults with T1DM. Theobjectives of this study were to characterize and quantify the relationship between routine daily activity and glucose variations in a small group ofadults with T1DM. We show that physical activity and glucose demonstrate strong time and frequency-dependent coupling throughout a 24-h timeperiod in adults with T1DM.

Impact of UGT2B17 gene deletion on the steroid profile of an athletePilar Martín-Escudero, Jesús Muñoz-Guerra, Nayade Del Prado, Mercedes Galindo Canales, Manuel Fuentes Ferrer, Soledad Vargas, AnaB. Soldevilla,Ester Serrano-Garde, Francisco Miguel-Tobal, Marisa Maestro de las Casas,Cristina Fernandez-PérezDecember 14, 2015 : e12645

DOI: 10.14814/phy2.12645

This article is significant in the area of science, as it is the first study with Spanish athletes.

This study includes a genetic study of each athlete in relation to UGT2B17 gene and its influence on the testosterone/epitestosterone ratio.

WADA needs to consider the influence of the human race in the steroid profile.

Altered intrinsic and network properties of neocortical neurons in the Ts65Dn mouse model of Down syndromeNathan P. Cramer, Xiufen Xu, Tarik F. Haydar, Zygmunt GaldzickiDecember 23, 2015 : e12655

DOI: 10.14814/phy2.12655

Spontaneous synaptic events and coordinated network activity are less frequent in the somatosensory cortex of 2–3 week old Ts65Dn mice, the moststudied mouse model of Down syndrome. Abnormal network activity combined with a decreased specific membrane resistance of layer 4 neuronssuggests that information flow through the neocortex is impaired in these mice. Such changes, if present in the neocortex of Down syndromeindividuals may impact their cognitive abilities.

Physiological basis for muscle stiffness and weakness in a knock-in M1592V mouse model of hyperkalemic periodic paralysisShiemaa Khogali, Brooke Lucas, Tarek Ammar, Danica Dejong, Michael Barbalinardo, Lawrence J. Hayward, Jean-Marc RenaudDecember 23, 2015 : e12656

DOI: 10.14814/phy2.12656

This study further characterized the mechanisms that cause muscle stiffness and weakness in Hyperkalemic Periodic Paralysis (HyperKPP). Musclestiffness is caused by an increased membrane hyperexcitability as action potentials are generated in the absence of motorneuron stimulation inrandom as opposed to myotonic discharges as clinically defined. Muscle weakness is caused by localized increases in extracellular potassiumconcentration that cause membrane hypoexcitability in a few fibers at a time.

Expression of human carcinoembryonic antigen-related cell adhesion molecule 6 and alveolar progenitor cells in normal and injured lungs oftransgenic miceShin-e Lin, Anne Marie Barrette, Cheryl Chapin, Linda W. Gonzales, Robert F. Gonzalez, Leland G. Dobbs, Philip L. BallardDecember 23, 2015 : e12657

DOI: 10.14814/phy2.12657

Transgenic mice containing human Carcinoembryonic Cell Adhesion Molecule genes express CEACAM6 in selected, unidentified lung epithelialcells at levels comparable to the human infant. Expression is increased in three models of lung injury with some localization to epithelial cellsexpressing both type 1 and type 2 cell markers. We propose that CEACAM6 in this model is a marker of a progenitor cell population thatcontributes to alveolar epithelial cell replenishment after lung injury.

Forced expression of muscle specific kinase slows postsynaptic acetylcholine receptor loss in a mouse model of MuSK myasthenia gravisNazanin Ghazanfari, Erna L. T. B. Linsao, Sofie Trajanovska, Marco Morsch, Paul Gregorevic, Simon X. Liang, Stephen W. Reddel, WilliamD. PhillipsDecember 23, 2015 : e12658

DOI: 10.14814/phy2.12658

Autoimmune antibodies against Muscle Specific Kinase (MuSK) are thought to cause some cases of myasthenia gravis. The pathogenic effects ofthese antibodies on the mouse neuromuscular junction were ameliorated by supplementing the expression of MuSK. This confirms that MuSKautoantibodies cause myasthenia gravis by impairing MuSK function.

Renal iron overload in rats with diabetic nephropathyJesus H. Dominguez, Yunlong Liu, Katherine. J. KellyDecember 23, 2015 : e12654

DOI: 10.14814/phy2.12654

Rats with diabetic nephropathy have renal iron overload from derived from renal dysfunction. The excessive renal iron is a risk factor for lipidperoxidation and renal injury.

Heat acclimation and thirst in ratsChristopher C. Barney, Elizabeth M. Schanhals, Justin L. Grobe, Bradley T. Andresen, Michael TraverDecember 23, 2015 : e12642

DOI: 10.14814/phy2.12642

Heat acclimation did not alter the ability of rats to rehydrate following thermal dehydration but did reduce the level of evaporative water loss and therate at which thermal dehydration developed. Heat acclimation of rats enhanced the water intake response to angiotensin II, a hormone that plays animportant role in volemic thirst, without altering the water intake responses to increases in plasma osmolality/sodium concentration induced byadministration of hypertonic saline. Heat acclimation also increased water intake and improved hydration after 24 h of water deprivation.

ALL REVIEWS*

Advances in high-density lipoprotein physiology: surprises, overturns, and promisesCaterina Constantinou, Eleni A. Karavia, Eva Xepapadaki, Peristera-Ioanna Petropoulou, EugeniaPapakosta, Marilena Karavyraki, Evangelia Zvintzou, Vassilis Theodoropoulos, Serafoula Filou,Aikaterini Hatziri, Christina Kalogeropoulou, George Panayiotakopoulos, Kyriakos E. KypreosJanuary 1, 2016 : E1-E14

DOI: 10.1152/ajpendo.00429.2015

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DOI: 10.1152/ajpregu.00392.2014

Discerning the role of mechanosensors in regulating proximal tubule functionVenkatesan Raghavan, Ora A. WeiszJanuary 1, 2016 : F1-F5

DOI: 10.1152/ajprenal.00373.2015

Mesenchymal stem cells and chronic renal artery stenosisElizabeth B. Oliveira-Sales, Mirian A. BoimJanuary 1, 2016 : F6-F9

DOI: 10.1152/ajprenal.00341.2015

Mini-review: regulation of the renal NaCl cotransporter by hormonesLorena Rojas-Vega, Gerardo GambaJanuary 1, 2016 : F10-F14

DOI: 10.1152/ajprenal.00354.2015

Physical activity-induced remodeling of vasculature in skeletal muscle: role in treatment of type 2 diabetesM. Harold LaughlinJanuary 1, 2016 : 1-16

DOI: 10.1152/japplphysiol.00789.2015

Cardiovascular Tissue Engineering: Preclinical Validation to Bedside ApplicationCameron Best, Ekene Onwuka, Victoria Pepper, Malik Sams, Jake Breuer, Christopher BreuerDecember 11, 2015 : 7-15

DOI: 10.1152/physiol.00018.2015

Exosomal miRNAs in Heart DiseaseClaudio Iaconetti, Sabato Sorrentino, Salvatore De Rosa, Ciro IndolfiDecember 11, 2015 : 16-24

DOI: 10.1152/physiol.00029.2015

Novel Functions of Renin Precursors in Homeostasis and DiseaseR. Ariel Gomez, Maria Luisa S. Sequeira-LopezDecember 11, 2015 : 25-33

DOI: 10.1152/physiol.00039.2015

Pulsatility of Hypothalamo-Pituitary Hormones: A Challenge in QuantificationDaniel M. Keenan, Johannes D. VeldhuisDecember 16, 2015 : 34-50

DOI: 10.1152/physiol.00027.2015

The Chemistry of Cold: Mechanisms of Torpor Regulation in the Siberian HamsterCeyda Cubuk, Jonathan H. H. Bank, Annika HerwigDecember 16, 2015 : 51-59

DOI: 10.1152/physiol.00028.2015

The Role of Hydrogen Sulfide in Evolution and the Evolution of Hydrogen Sulfide in Metabolism and SignalingKenneth R. Olson, Karl D. StraubDecember 16, 2015 : 60-72

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* Does not include Physiological Reviews