JAMES M. KRUEGER WWAMI Medical Education Program … · CURRICULUM VITAE JAMES M. KRUEGER WWAMI Medical Education Program ... Rachida Roky, Ph.D. (1994) Sergei Novitsky, Ph.D., M.D.,

August 2013

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CURRICULUM VITAE

JAMES M. KRUEGER WWAMI Medical Education Program

Sleep and Performance Research Center

Washington State University Spokane, WA 99210-1495

Email: [email protected]

Fax: (509) 358-7627

Telephone: (509) 358-7808

Scholastic Record:

B.S. 1966 University of Wisconsin, Madison

Ph.D. 1974 University of Pennsylvania, Philadelphia (Physiology)

MDHC 2005 University of Szeged, Hungary, Doctorem Medicinae Honoris Causa

Professional Experience:

1968-1969 Teaching Assistant (Embryology and Comparative Anatomy): Department of Zoology, University of Wisconsin

1969-1974 NIH Fellowship: from the Institute of Neurological Sciences, University of Pennsylvania

1974-1976 Research Fellow: Department of Physiology, Harvard Medical School

1976-1978 Instructor (in Physiology): Department of Physiology, Harvard Medical School

1978-1981 Principal Research Associate: Department of Physiology, Harvard Medical School

1981-1985 Assistant Professor: Department of Physiology and Biophysics, University of Health Sciences/Chicago Medical School

1985-1987 Associate Professor: Department of Physiology and Biophysics, University of Tennessee

1987-1997 Professor: Department of Physiology and Biophysics, University of Tennessee, Memphis

1997-1999 Chair: Department of Veterinary and Comparative Anatomy, Physiology and Pharmacology, Washington State University

1997-2007 Professor: Department of Veterinary and Comparative Anatomy, Physiology and Pharmacology, Washington State University

2007-PRESENT Regents Professor, Washington State University

KRUEGER, James M.

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2013-PRESENT Affiliate Professor, Department of Anesthesiology & Pain Medicine, University of Washington

Scientific Organizations:

American Academy of Sleep Medicine

American Physiological Society (1974-2003)

American Society for Microbiology

International Society for Neuroimmunomodulation

Sleep Research Society (Publications Chair: 1992-1995; Member: 1998-2014)

Society for Neuroscience

Honors and Awards:

American Heart Association: Career Investigator Fellow (1978-1979)

Chicago Medical School: Board of Trustees Research Award (1983)

Tokyo Medical and Dental University: Honorary Award (1990)

University of Tennessee-Memphis: President of Faculty Senate (1995-1996)

NIH/NINDS: Javits Award (1997-2004)

Nanjing Medical University: Visiting Professor (1999)

Neuroscience Grass Traveling Scientist, Jackson, MS (2000)

Washington State University: Sahlin Faculty Excellence Award for Research (2001)

Washington State University College of Veterinary Medicine: Pfizer Award for Research Excellence (2003)

Doctorem Medicinae Honoris Causa: University of Szeged, Hungary (2005)

Distinguished Scientist Award: Sleep Research Society (2006)

Pfizer Lectureship in Sleep: University of Michigan (2006)

Eminent Faculty Award: Washington State University (2010)

Honors College Faculty Thesis Advisor of the Year; WSU (2012)

Washington State Academy of Sciences (elected 2012)

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Administrative Activities:

University of Health Sciences/Chicago School of Medicine

University / College

Ad Hoc Committee on Affirmative Action

Ad Hoc Committee to Evaluate the Organization, Function, and Administration of the Basic Science Departments

Ad Hoc Committee on Fringe Benefits

Ad Hoc Committee on Patent Policy

Committee for Faculty Affairs

Committee for Faculty/Student Forum

Faculty Senate, Member (1983-1985)

Departmental

Ad Hoc Committee for Graduate Student Research Award

LCME Task Force Subcommittee on Evaluating the Department of Biochemistry

Search Committee for Chair of Department of Microbiology

University of Tennessee-Memphis

University / College

Faculty Senate:

Member (1990-1992, 1994-1996)

Executive Committee (1990-1992)

Forum Committee (1991-1992)

President (1995-1996)

Education Council (1994-1995)

Faculty Counselor to the President of the University of Tennessee (1994-1995)

University Planning Committee (1994-1996)

Academic and Student Affairs Committees of the University of Tennessee Board of Trustees (1995)

Neuroscience Coordinating Committee

Recombinant DNA Committee

Departmental

Graduate Training Committee

Grant-Release Money Committee

Search Committee for Chair of Department of Physiology

Search Committee for Assistant Professor of Department of Physiology (1991)

Tenure and Promotions Committee

KRUEGER, James M.

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Washington State University

University

Faculty Senate (2000-2004; 2013-)

Search Committee for Dean of College of Pharmacy

Search Committee for Director of OGRD, Chair

Search Committee for Vice Provost for Research

Search Committee for Chancellor-Spokane

Search Committee for Sleep Faculty Position-Spokane

College

Research Committee (Chair: 2002; 2010)

CVM Tenure and Promotion Committee (2009-2010)

Departmental

Graduate Curriculum Committee

Search Committee for Faculty for Department of VCAPP (Chair)

Space Committee

VCAPP Planning Committee

Undergraduate Curriculum Committee

Other

Helped organize sleep faculty position for WSU-Spokane

Participated in WSU’s biotechnology television commercial

Student Advisor for Undergraduate Neuroscience Program

Congressional Fact-Finding Tour

Research Misconduct Committee

WAMMI Faculty Search Committee (2008-2009: 2012-2013)

WSU Pre-medical advisory committee (2009-present)

Regional

Memphis Veterans Administration Medical Center: Research and Development Committee (1989-1991)

Mid-South Sleep Society, President (1991-1992)

University of Tennessee: Memphis Chapter of Sigma Xi, President (1992-1993)

National

American Physiological Society: Nervous System Section

National Congressional Commission on Sleep Disorders: Future Approach to the Neurobiology of Sleep; Woodshole, MA (1991)

National Academy of Sciences – Institute of Medicine: Research Briefing Panel on Basic Sleep Research

Sleep Research Society: Publications, Chair (1991-1994; 1997-2000)

Reviewing Activities:

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Grants

Member

NIH/National Institutes for Mental Health (NIMH): Behavioral Neuroscience Review Committee [also called “Psychobiology, Behavior and Neuroscience”] (1992-1996)

Ad-hoc

American Institute for Biological Sciences

Arthritis Society of Canada

Australian Research Council

Medical Research Council of Canada

National Institutes of Health (NIH) (ad hoc 2000-2012)

National Institute for Mental Health (NIMH)

National Science Foundation (NSF) (ad hoc 2000-2013)

Swiss National Science Foundation

United States Air Force (USAF)

United States – Israel Binational Science Foundation

Veterans Administration (VA)

Societe Francaise de Recherche et Medecine du Sommeil, 2010

Biotechnology and Biological Sciences Research Council, United Kingdom, 2010

Deutsche Forschungsgemeinschaft (German Research Foundation) 2012

UK Medical Research Council, April 2013

NSF study section, March 2013

Washington State University – Drug and Alcohol Abuse Program May, 2013

NSF, ad hoc, September 2013

Manuscripts

Editorial Board Member

American Journal of Physiology (1994-1997)

Journal of Sleep Research (2003-Present)

Neuroendocrinology (1995-1999)

Neuroimmunomodulation

Sleep Research Online (Biochemistry Section Editor)

World Federation of Sleep Research Societies Newsletter (“Conceptional and Theoretical Issues in Sleep” – Section Editor) (1998-2000)

International Journal of Interferon, Cytokine and Mediator Research (2008-Present)

Ad-hoc

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American Journal of Physiology

American Journal of Primatology

Brain Research

Brain, Behavior and Immunity

Current Biology

Cytokine

European Journal of Neuroscience

Federation Proceedings (FASEB Journal)

International Journal of Immunopharmacology

Journal of American Medical Association

Journal of Biological Chemistry

Journal of Clinical Investigation

Journal of Immunology

Journal of Immunotherapy

Journal of Interferon Research

Journal of Leukocyte Biology

Journal of Neuroscience

Journal of Physiology (London)

Journal of Sleep Research

Journal of Thermal Biology

Life Sciences

Nature

Neurobiology of Disease

Neuroendocrinology

Neuroimmunomodulation

Neuron

Neuroscience

Neuroscience and Biobehavioral Reviews

New England Journal of Medicine

Peptide Research

Peptides

Pharmacology Biochemistry and Behavior

Physiological Reviews

Physiological Zoology

Physiology and Behavior

Proceedings for the National Academy of Sciences (USA)

Psychopharmacology

Psychosomatic Medicine

Science

Sleep

Sleep Medicine Reviews

Trends in Neuroscience

KRUEGER, James M.

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Patents:

Sleep Promoting Factor: issued August 3, 1982 [#4,342,748]

Somnogenic Compositions and Method of Use: issued May 26, 1987 [#4,668,661]

Interleukin-1 Fragment - Method of Inducing Sleep: issued December 24, 1991 [#5075288]

Complementary Peptides - Method of Inducing Sleep With GHRH Complementary Peptide Compositions: issued October 6, 1992 [#5153175]

Administering Bacteria to Improve Sleep: issued September 23, 2002 (#6,444,203 B2)

Method for reduction in caloric intake; GHRELIN siRNA administration. No. 8,309,530 B2; issued Nov 13, 2012.

Gene Bank:

Accession No. AF 154114 Rattus norvegicus peptidoglycan recognition protein (PGRP) June 1, 2000

Accession No. NM 133381 Rattus norvegicus CREB-binding protein (Crebbp) mRNA November 25, 2003

Accession No. GU123169 Rattus norvegicus interleukin 1 receptor accessory protein b

November 10, 2009

Teaching Experience:

University of Wisconsin, Milwaukee

Department of Zoology

Embryology, Comparative Anatomy and Introductory Zoology (1968-1969)

University of Pennsylvania, Philadelphia

Department of Physiology

Dental Physiology (1970)

Cellular Physiology (1973)

Medical Physiology (1974)

Harvard School of Medicine, Boston

Department of Physiology

Medical Physiology (1975-1981)

University of Health Sciences/Chicago School of Medicine, North Chicago

Department of Physiology and Biophysics

Medical Physiology and Neuroscience (1981-1985)

University of Tennessee, Memphis

Department of Physiology and Biophysics

KRUEGER, James M.

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Neurophysiology (1985-1997)

Cellular Neuroscience (1988)

Neuroendocrinology (1992, 1996)

Washington State University, Pullman

Veterinary & Comparative Anatomy, Pharmacology & Physiology (VCAPP)

Neuro 138: Sleep (1998-2012)

Neuro 301: Exploring the Brain (1999-2004, 2007-2009)

Neuro 495: Neuroscience Laboratory (2001-2009)

Neuro 499: Neuroscience Readings (2001-2009)

Neuro 520: Functional Neuroscience (1999, 2002)

Neuro 529: Cellular & Molecular Neurobiology (2002-2009)

Neuro 540: Special Topics in Integrative Neurobiology (2002, 2006, 2011)

Neuro 543: Biological Rhythms (2005)

Neuro 543: Sleep (2011)

Students and Fellows Having Received Training in My Laboratory:

Postdoctoral Fellows and Others

University Health Services/Chicago Medical School

James Walter, Ph.D. (1982-1985)

Shai Shoham, Ph.D. (1984-1986)

Damien Davenne, Ph.D. (1984-1986)


Linda Toth, Ph.D., D.V.M. (1986-1988); Assistant Professor (1988-1992)

Lars Johannsen, Ph.D. (1986-1989); Assistant Professor (1989-1990)

Alan Cady, Ph.D. (1986-1989)

Lovorka Stojanov, M.D. (1987-1988)

Ferenc Obál, Jr., M.D., Ph.D. (1987-1989); Visiting Professor (1991-2003)

Mark Opp, Ph.D. (1987-1989); Assistant Professor (1989-1993)

Levente Kapás, M.D. (1989-1992); Assistant Professor (1992-1996)

Mayumi Kimura-Takeuchi, Ph.D. (1990-1993)

Luca Imeri, M.D. (1991-1992)

Sebastian Bredow, Ph.D. (1991-1996)

Jidong Fang, Ph.D., M.D. (1991-1997**)

John Harris, Ph.D., Adjunct Professor (1993)

Satoshi Takahashi, Ph.D., M.D. (1993-1996)

Rachael A. Floyd, Ph.D., Instructor (1993-1997)

Rachida Roky, Ph.D. (1994)

Sergei Novitsky, Ph.D., M.D., Visiting Teaching Fellow (1995)

Tetsuya, Kushikata, M.D., Research Associate (1995-1997**)

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Zutang Chen, Ph.D., Research Associate (1996-1997**)

Ping Taishi, M.D., Research Associate (1996-1997**)

Janos Gardi, Ph.D., Research Associate (1997**)

Zhiwei Guan, M.D., Research Associate (1997-1997**)


Zutang Chen, Ph.D., Research Associate (1997**-1999)

Jidong Fang, Ph.D., M.D. (1997**-2000)

Janos Gardi, Ph.D., Research Associate (1997**-2005, 2007-2008)

Ping Taishi, M.D., Research Associate (1997**-PRESENT)

Tetsuya, Kushikata, M.D., Research Associate (1997**-1999)

Zhiwei Guan, M.D., Research Associate (1997**-2000)

Sherman Ye, Ph.D., Research Associate (1998-1999)

Ildiko Hajdu, M.D., Research Associate (1998-1999)

Abdur Rehman, Ph.D., Research Associate (1998-2001)

Lynn Churchill, Ph.D., Research Associate Professor (1998-2010)

Monica Gonzalez, Ph.D., Research Associate (1999-2000)

Takeshi Kubota, M.D., Research Associate (1999-2001)

Alok De, Ph.D., Research Assistant Professor (2000-2008)

Hitoshi Yoshida, M.D., Ph.D., Research Associate (2001-2002)

Fabio Garcia-Garcia, Ph.D., Postdoctoral Associate (2001-2004)

Zoltan Peterfi, Ph.D., Postdoctoral Associate (2001-2003)

Scott Nelson, Ph.D., Research Assistant Professor (2002-2004)

Linda Dickerson, Ph.D., Research Assistant Professor (2003-2004)

Tadanobu Yasuda, M.D., Ph.D., Postdoctoral Associate (2003-2005)

Kyo Yasuda, M.D., Ph.D., Postdoctoral Associate (2003-2005)

Éva Szentirmai, M.D., Postdoctoral Associate (2005-2009)

Chris Davis, Ph.D., Postdoctoral Associate (2005-PRESENT)

Parijat Sengupta, Ph.D. Research Assistant Professor (2008- 2011)

Mark Zielinski, Ph.D. Postdoctoral Fellow (2009- 2011)

[** Moved with me to Washington State University from University of Tennessee]

Medical Students


Allan Adler (1982)

Carolyn Levin (1983)

Robert Aizenstein (1983)

Dan Muse (1984)


John Endsley (1986)

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Brad Greenbaum (1992)

Chris Sanborn (1993)

Greer Richardson (1994)


Danielle Nelson (2002)

Graduate Students


Joseph Karaszewski (1983-1986)


Lielie Hong, M.D.: Ph.D. thesis defended November 1992 (1988-1992)

Linda Payne: Ph.D. thesis defended April 1992 (1988-1992)

Edward Fincher: Ph.D. thesis defended August 1994 (1990-1994)

Jianyi Zhang: Ph.D. thesis defended October 1998 (1994-1998)

Michael Hansen: Ph.D. thesis defended March 1998 (1994-1998)


Judy Brandt: Master’s thesis defended (2001)

Lichao Chen, M.D.: Ph.D. thesis defended (2003)

Jeremiah Alt: Ph.D. thesis defended (2003)

Victor H. Leyva-Grado: Ph.D. Program Veterinary Sciences (PhD Thesis defended 2008)

Fan Liao: Ph.D. Thesis Student (PhD Thesis defended 2010)

Kathryn Jewett (2010-PRESENT)

Undergraduate


Mark Blakemore, Memphis Challenge/Summer Internship (1991)

Monica Kegler, Shelby State/Upward Bound Program (1991-1992)

JoAnne Lewis, Shelby State/Upward Bound Program (1991-1992)

Jerrod Roussel, Rhodes College/Summer Student (1992)

Marile Brisco, LeMoyne-Owens/Summer Student (1992)

Chris Somogyi, Memphis State University/Summer Student (1993)

Christopher Gatewood, LeMoyne-Owen College/Undergraduate (1993-1994)

Dawn Tooley, Christian Brothers University/Senior Thesis (1995)

Sonya Gala, Christian Brothers University/Senior Thesis (1996)

Washington State University, Pullman Post graduate degree

Stephanie Harding, McNair Scholar (2001)

Tiffany Ludka, WSU, Neuroscience (2001) MD

Amanda McIntire, WSU, Neuroscience (2001)

Mee JaSula, Whitman College (2001, 2002) DVM

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Matthew Jenkins, WSU, Neuroscience (2001) MD

Andrew Seaman, WSU, Neuroscience (2003) MD

Kim-Thay Truong, Seattle University (2003) MD

Cassia Cearley, WSU, Neuroscience (2003) PhD

Daniel Kay, WSU Psychology (2006) PhD

Chad Tang, Case-Western University (2003) MD

Michael Falter, WSU Neuroscience (2006)

Kelly Blindheim, WSU Neuroscience (2006)

Cora Fix, WSU Neuroscience, Honors with Distinction (2006)

Lissette Jimenez, WSU Neuroscience (2007) MD

Lindsey Muir, WSU Neuroscience, Honors with Distinction (2006) PhD

Paul Magrath, WSU Neuroscience (2007) DVM

Joe Meyerson, WSU Neuroscience (2008) MD

Marc Urza, WSU Neuroscience (2007) DDM

Sarah Hall, WSU Neuroscience (2007)

Carl Martensen, WSU Neuroscience (2007) MD

Krista Ingalsbe, WSU Neuroscience (2007) DVM

Darrell Plummer, WSU Neuroscience (2008)

Heather Hallett, WSU Neuroscience (2009) MD

Jourdan Carboy, WSU Neuroscience (2008-2009)

Nicole Sawatzki, WSU Neuroscience Honors with Distinction (2010) MD

Kimberly Gering, WSU Neuroscience, (2011) PhD

Danielle Dunbrasky, WSU Neuroscience (2009-)

Andrea Boucher, WSU Neuroscience (2011) DVM

Gianna Souza, WSU Biology Honors with Distinction (2011) PhD

Omar Bayomy, WSU Neuroscience (2009-2013) MD

Derick En’Wezoh, WSU Neuroscience (2009) MD

High School Students

Ferrell Moore, Trezevant High School/Summer Student (1993)

Thesis Committees


James Walter (Physiology, 1982)


Victoria Schanmloffel (Physiology, 1990)

Ron Cowan (Anatomy, 1990)

Jerry Lovelace (Biochemistry, 1991)

Ning Quan (Physiology, 1991)

Adam Book (Anatomy, 1993)

Eric Laywell (Anatomy, 1993)

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Pauline Hsu (Physiology, 1994)

Demin Wang (Biochemistry, 1995)

Monte Gates (Anatomy, 1995)


Greg Fraley (Ph.D., Neurobiology, 1998)

Shane Hentges (Ph.D., Neurobiology, 1999)

Jodi Dickstein (Ph.D., Institute of Medical Science, University of Toronto, 1999)

Claire Matson (Ph.D., Neurobiology, 2000)

Suang Li (Ph.D., Neuroscience, 2003)

Indika Rajapakse (Ph.D., Mathematics, 2004)

Christopher Davis (Ph.D., Psychology, 2005)

Amber Smith (Ph.D. candidate, Mathematics, 2007)

Brad Winters (Ph.D. Neuroscience, 2008-2012)

Patrick Corrigan (MS, Electrical Engineering 2010-2011)

Chih Chen (MS, Electrical Engineering 2012)

Derrick Phillips (MS, Neuroscience 2012)

Invited Presentations at Symposia:

1. FASEB: Physiological properties of sleep-promoting Factor S extracted from brain and urine; Dallas, TX. (1979)

2. APSS: Isolation and partial characterization of a slow-wave sleep factor; Hyannis, MA. (1981)

3. 6th European Congress of Sleep Research: Sleep-promoting Factor S: characterization and analogs; Zurich, SWITZERLAND. (1982)

4. 4th International Congress of Sleep Research: Factor S, muramyl peptides and interleukin-1: related physiological properties; Bologna, ITALY. (1983)

5. Sleep Research Society: Peptide neuromodulators, sleep and temperature; Toronto, Quebec, CANADA. (1984)

6. Janssen Research Foundation: Endogenous sleep factors; BELGIUM. (1984)

7. 13th International Congress of Psychology: Somnogenic muramyl peptides and interleukin-1; Acapulco, MEXICO. (1984)

8. Walter Reed Army Institute of Research – Pharmacological Optimization of Performance Symposium: Sleep neuromodulators; Washington, DC. (1984)

9. Taniguchi Symposium; Kyoto, JAPAN. (1984)

10. FASEB Meeting – Symposium: Muramyl peptides as modulators of sleep, temperature and immune responses. (1985)

11. 1st International Workshop on Neuroimmunomodulation; Bethesda, MD. (November

1984)

12. 2nd

International Workshop: Biological activity of peptidoglycan; München, GERMANY. (May 1985)

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13. Conference: Current problems in testing and evaluation of experimental and clinical effects of immunomodulators; Prague, CZECHOSLOVAKIA. (May 1985)

14. Conference: The physiologic, metabolic and immunologic actions of interleukin-1; Ann Arbor, MI. (June 1985)

15. Conference: The first Non-REM period and just beyond; Seattle, WA. (July 1985)

16. Conference: Living in the cold; South Lake Tahoe, CA. (October 1985)

17. NIH Workshop on Respiratory Disorders of Sleep: Neuropharmacology of sleep; Washington, DC. (March 1986)

18. 6th International Congress on Immunology – Satellite Symposium: Peptide neuromodulators of sleep; Toronto, Quebec, CANADA. (July 1986)

19. 2nd

International Workshop on Neuroimmunomodulation: Sleep and the immune response; Dubrovnik, CZECHOSLOVAKIA. (June 1986)

20. Endotoxin and Lipid A-Enhanced Sleep: Endotoxin: structural aspects and immunobiology of host responses; Bari, ITALY. (May 1986)

21. Sleep Research Society – Immunology and Sleep Symposium: The influence of the immune system on sleep; Columbus, OH. (June 1986)

22. CINP Meeting: Endogenous sleep regulating substances; San Juan, PR. (December 1986)

23. Conference: Endogenous slow-wave sleep substances. Current trends in slow-wave sleep research; Beerse, BELGIUM. (June 1987)

24. 5th International Congress Sleep Research: Immunomodulation and sleep; Copenhagen, DENMARK. (July 1987)

25. UCLA Western Winter Workshop – Cellular and Molecular Biology of Neural-Immune Interactions: Induction of slow-wave sleep by muramyl peptides, IL1 and other immunopeptides; Lake Tahoe, CA. (March 1988)

26. Arthritis Foundation – Fibromyalgia/Fibrositis Symposium: Sleep and immune response modifiers; Palm Springs, CA. (March 1988)

27. Conference: Peptidergic sleep factors. Sleep and biological rhythms: basic mechanisms and application to psychiatry; Montreal, Quebec, CANADA. (May 1988)

28. 4th Congress on Immunopharmacology: Enhancement of mammalian sleep by immune modulators; Osaka, JAPAN. (May 1988)

29. 2nd

Workshop on Psychoneuroimmunomodulation: Sleep and immune regulation; Fukuoka, JAPAN. (May 1988)

30. Conference: Immune response modifiers and sleep. Interactions between neuroendocrine and immune systems; Cantanzaro, ITALY. (June 1988)

31. European Society for Neurochemistry: Muramyl peptides and sleep; Goteburg, SWEDEN. (June 1988)

32. Nordisk Insulin Symposium: Molecular mimicry in health and disease; Copenhagen, DENMARK. (August 1988)

33. Joint U.S.A.-Japan NSF Symposium on Endogenous Sleep Factors (J. Krueger and S. Inoué, organizers); Hawaii. (November 1988)

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34. American Society for Neurochemistry: The neuro-immune axis; Chicago, IL. (March 1989)

35. FASEB Meeting – Symposium: CNS mechanisms of host-defense responses; New Orleans, LA. (March 1989)

36. Banff Conference: Sleep and breathing; Banff, Alberta, CANADA. (April 1989)

37. International Society for Neuroimmunomodulation: Distress, neuroimmunomodulation, and ontogeny; Madonna di Campiglio, ITALY. (July 1989)

38. Sleep Research Society Symposium: Infectious disease and sleep; Washington, DC. (June 1989)

39. ENA Satellite Symposium: Diencephalon and sleep; Como, ITALY. (September 1989)

40. 6th International Symposium: Neuronal control of bodily function; Laguna Beach, CA. (October 1989)

41. Winter Conference on Brain Research: Communications signals between the immune and central nervous systems; CO. (1990)

42. World Federation of Sleep Research Societies: Slow-wave sleep: its measurement and functional significance; Los Angeles, CA. (April 20-22, 1990)

43. American Society Microbiology Symposium: Novel interactions of bacteria, brains and bugs: the biology of peptidoglycan; Anaheim, CA. (May 1990)

44. 10th ESRS Congress: Hormones and sleep; Strasbourg, AUSTRIA. (May 1990)

45. 7th International Symposium: Neuronal control of bodily function; Mainz, GERMANY. (September 1990)

46. NICHD Workshop: Animal models of SIDS. Washington D.C. (October 1990)

47. 3rd International Congress: Sleep and cytokines, tumor necrosis factor and related cytokines; Tokyo, JAPAN. (November 21-25, 1990)

48. Winter Conference on Brain Research: Modulation of slow wave sleep by thermoregulatory, metabolic and immunological factors. CO (1991)

49. Conference: Sleep and sleep disorders; Amsterdam, The NETHERLANDS. (1991)

50. 3rd Milano International Symposium on Sleep: Sleep hormones and immunological systems; Milan, ITALY. (September 1991)

51. World Federation of Sleep Research Societies: Endogenous sleep factors; Cannes, FRANCE. (September 1991)

52. Army Research Psychological Meeting; Washington, DC. (1991)

53. M.D. Anderson Cancer Center: Effects of cytokines on the nervous system; Houston, TX. (November 1991)

54. UCLA Symposium: Cytokines in growth, development and pathogenesis; Taos, NM. (1992)

55. Winter Brain Conference: CNS mediation of acute extraneural viral infections or ‘how the flu makes you sick’; Steamboat Springs, CO. (1992)

56. American Thoracic Society: Cytokines in sleep, cytokine and cytokine receptor biology; Miami, FL. (May 1992)

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57. Conference: Cytokines and sleep, advances in psych-neuro-immunology; Budapest, HUNGARY. (1992)

58. British Sleep Society: Chemical influences on sleep mechanisms; Leicester, UNITED KINGDOM. (September 1992)

59. International Conferences on Sleep-Wakefulness: Sleep inducing substances; New Delhi, INDIA. (September 1992)

60. A Philippe Landat Conference: Cytokines in the brain; Le Birschenberg, FRANCE. (October 1992)

61. Conference: Chronic fatigue syndrome; Baptist Memorial Hospital. Memphis, TN (December 1992)

62. Cellular Consequences of Sleep Conference: Sleep and immunology: clinical and pre-clinical perspectives; Hawaii. (1993)

63. Cellular Consequences of Sleep Conference: Humoral regulation of sleep; Hawaii. (1993)

64. Cellular Consequences of Sleep Conference: Molecular correlates of sleep; Hawaii. (1993)

65. Cellular Consequences of Sleep Conference: Immunocytes, infection and sleep; Hawaii. (1993)

66. ONR Workshop on Immunophysiology: Viral challenge, interferons and sleep; Washington, DC. (March 1993)

67. International Society for Neuroimmunomodulation: Cytokine influences on central nervous and endocrine systems; Denver, CO. (May 1993)

68. 2nd

Annual NIAID Workshop: Chronic fatigue syndrome; Bethesda, MD. (June 1993)

69. Association of Professional Sleep Societies – CME Course: The neurobiologic basis of sleep; Los Angeles, CA. (June 1993)

70. MacArthur Foundation: Mind-body interactions network; San Francisco, CA. (September 1993)

71. Winter Neuropeptide Conference: Cytokines and the brain; Breckenridge, CO. (February 1994)

72. Society for Research on Biological Rhythms; Jacksonville, FL. (May 1994)

73. The Function of Sleep; Ravello, ITALY. (May 1994)

74. American Physiological Society: Physiology of the release and activity of cytokines; Yale University, New Haven, CT. (June 1994)

75. Gordon Research Conference: Neuroendocrine immunology; NH. (June 1994)

76. Conference: Neuroimmunomodulation - stress and immune function; The Lovelace Institutes, Albuquerque, NM. (October 1994)

77. Conference: Future therapeutics for disorders of sleep and circadian rhythms; Bristol-Myers Squibb Company; Princeton, NJ. (September 1994)

78. APSS Annual Meeting: Prolactin in REM sleep regulation; Nashville, TN. (June 1995)

79. APSS Annual Meeting: Sleep factors: virtual redundancy or real synergy; Nashville, TN. (June 1995)

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80. APSS Annual Meeting: The function of sleep; Nashville, TN. (June 1995)

81. Conference: The future of sleep research at NIMH; Bethesda, MD. (June 22-23, 1995)

82. Conference: Cytokines as communication factors between the brain and the immune system; Arachron, FRANCE. (September 1995)

83. World Federation of Sleep Research Societies: Brain organization and sleep; Nassau, BAHAMAS. (September 1995)

84. World Federation of Sleep Research Societies: Sleep and the immune system, circa 1995; Nassau, BAHAMAS. (1995)

85. World Federation of Sleep Research Societies: Growth factors in sleep regulation; Nassau, BAHAMAS. (1995)

86. NIH Workshop: Molecular biology and genetic approaches to sleep control. Washington D.C. (September 1995)

87. 5th Naito Conference: Neuro-immuno-endocrine networks; Gifu, JAPAN. (October 1995)

88. 15th International Symposium of UOEH: Occupational health, time and space. (October 1995)

89. Conference: Somnogenic factors apnea of infancy; Palm Springs, CA. (January 18-20, 1996)

90. Northeastern Sleep Society – Keynote presentation; Warwick, RI. (April 1996)

91. European Sleep Research Society: Sleep in host defense: animal models and mechanisms; Brussels, BELGIUM. (June 1996)

92. Conference: Towards the cause of narcolepsy; Washington, DC. (September 1996)

93. 9th Takeda Science Foundation Symposium on Bioscience; Kyoto, JAPAN. (December 1996)

94. Austral-Asian Sleep Association – Plenary lecture; Wellington, NEW ZEALAND. (April 1997)

95. APSS Annual Meeting: Gene knockout studies in sleep research; San Francisco, CA. (June 1997)

96. NIH/NHLBI Workshop: Chronobiology of asthma; Washington, DC. (September 15-16, 1997)

97. British Sleep Society; Edinburgh, SCOTLAND. (October 1997)

98. 5th International Symposium: Sleep and breathing; Edinburgh, SCOTLAND. (October 1997)

99. Conference: Molecular basis of fever and hyperthermia; Santa Fe, NM. (November 1997)

100. European Sleep Research Society: Genetics of sleep in mice; Madrid, SPAIN. (1998)

101. Society for Neuroscience Workshop: CSF as a communication pathway in the brain; Los Angeles, CA. (1998)

102. NIH/NSF Workshop: What is sleep? What is it good for? Washington, DC. (1998)

103. University of Chicago Workshop: Gammahydroxybutrate: mechanisms of action and clinical application; Chicago, IL. (April 1999)

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104. PNIRS Symposium: Sleep as a behavioral model of neuroimmune interactions; Galveston, TX. (April 1999)

105. NIH-NIAAA Workshop: Future directions to research on alcohol and sleep; Bethesda, MD. (May 1999)

106. Human Frontier Science Program Workshop: Sleep regulation; Strasbourg, FRANCE. (May 1999)

107. APSS Symposium: Cytokines in sleep mechanisms and pathologies; Orlando, FL. (June 1999)

108. NIH Workshop: Sleep and host defenses; Washington, DC. (August 1999)

109. WFSRS Symposium: Sleep biochemical cascades: interactions between sleep regulatory substances; Dresden, GERMANY. (October 1999)

110. WFSRS Symposium: NREMS brain organizations local vs. global; Dresden, GERMANY. (October 1999)

111. WFSRS Symposium: Genetics of sleep; Dresden, GERMANY. (October 1999)

112. WFSRS Focus Group: Paradoxes of orthodoxical sleep; Dresden, GERMANY. (October 1999)

113. WFSRS Symposium: Function of REM sleep: early and late structural, chemical and behavioral effects; Dresden, GERMANY. (October 1999)

114. APS Conference: Determinants of vigilance: interaction between sleep and the circadian systems; Ft. Lauderdale, FL. (October 1999)

115. NIH/NHLB1 SCOR Coordination Meeting: Neurobiology of sleep and sleep apnea; Bethesda, MD. (December 1999)

116. DARPA Conference: Science of fatigue, sleep and vigilance; Stanford University, Stanford, CA. (December 1999)

117. Meeting: The role of neural plasticity in chemical intolerance; Rockefeller University, NY. (June 2000)

118. Meeting: Inflammation, cytokines and neurobehavioral functions; Washington, DC. (October 2000)

119. NIH – State of the Science Conference: Chronic fatigue syndrome. October 2000.

120. Society for Neuroscience – Satellite Symposium: Cytokines and the brain; New Orleans, LA. (November 2000)

121. International Symposium on Sleep and Autonomous Function: Cytokines and neuroendocrines in sleep regulation; Marburg, GERMANY. (March 2001)

122. MacArther-Network-NIH – Science of Mind-Body Interactions: Sleep in host defenses; Bethesda, MD. (March 2001)

123. Meeting: Cytokine expression in brain, fermented food, fermentation and intestinal flora; Mexico City, MEXICO. (May 2001)

124. APSS Meeting: Analysis of sleep/wake states in mice; Chicago, IL. (June 2001)

125. APSS Meeting: Sleep as a model behavior for the study of CNS-immune interactions; Chicago, IL. (2001)

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126. NIH Meeting: Bioinformatics in neuroscience and sleep research; Bethesda, MD. (July 2001)

127. DARPA Workshop: Continuous assisted performance teaming; Las Vegas, NV. (August 2001)

128. Pacific Northwest Association of Toxicologists Meeting; Leavenworth, WA. (October 2001)

129. Mind-Body Network: Mind, brain, body and health initiative; Tucson, AZ. (January 2002)

130. NIH – National Cancer Institute: Biological mechanisms of psychosocial effects on disease. (February 2002)

131. European Sleep Research Society: The somatotropic axis and sleep; ICELAND. (June 2002)

132. APSS 16th Annual Meeting: Neuroendocrinology and sleep; Seattle, WA. (June 2002)

133. International Society for Neuroimmunomodulation: Cytokines, sleep and infection; Montpellier, FRANCE. (September 2002)

134. World Federation of Sleep Research Society/APSS: Sleep as a localized process: induction of EEG asymmetries by TNF; Chicago, IL. (June 2003)

135. World Federation of Sleep Research Society/APSS: Humoral mechanisms of sleep: implications for sleep function; Chicago, IL. (June 2003)

136. World Federation of Sleep Research Society/APSS: GHRH: A link between sleep and metabolism; Chicago, IL. (June 2003)

137. NIH Workshop: Neuro-immune mechanisms and chronic fatigue syndrome; Washington, DC. (June 2003)

138. M.D. Anderson – University of Texas: Mechanisms and treatment of cancer-related symptoms. Sleep. Houston, TX (February 2004)

139. Basic Science Colloquium: Cytokines in sleep regulation; M.D. Anderson, University of Texas. (February 2004)

140. Medical College of Wisconsin: Sleep performance, and neuro-plasticity; Department of Pediatrics. Milwaukee, WI (April 2004)

141. APSS 2004 Meeting: Year in review. Sleep Regulation, Philadelphia, PA. (June 2004)

142. SRS Annual Trainee Symposium: Grant writing and the review process; APSS 2004 Meeting; Philadelphia, PA. (June 2004)

143. F. Obál, Jr. Memorial Symposium: Prolactin in REMs regulation; Szeged, HUNGARY. (October 2004)

144. ESRS Symposium: The inner life of neurons; Local Regulation of Cortical Sleep; Prague, CZECH REPUBLIC. (October 2004)

145. Sleep Spark Workshop: Unilever; Flitwick, ENGLAND. (November 2004)

146. 13th Neuroscience Conference: Brain organization of sleep and sleep function; San Juan,

PUERTO RICO. (December 2004)

147. APSS Meeting – SRS Career Development Fair: Grant Writing. Denver, CO. (2005)

148 APSS Meeting: Stress and Sleep in Rodents. Denver, CO. (2005)

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149. APSS Meeting: Brain Organization of Sleep. Denver, CO. (2005)

150. French Society of Sleep Research: Infection and Sleep. Lyon, FRANCE. (November 25, 2005)

151. University of Szeged: Brain Organization of Sleep. Szeged, HUNGARY. (November 29, 2005)

152. Sleep Research Society – Primer on Basic Sleep: Animal Models in Sleep Research. San Diego, CA. (February 11, 2006)

153. American Academy of Allergy, Asthma and Immunology – Asthma in Sleep Immunity Workshop: The importance of sleep in the immune response. Miami, FL. (March 4, 2006)

154. SLEEP ’06: What is it that sleeps? Salt Lake City, UT. (June 17, 2006)

155. SLEEP ’06: Brain organization of sleep. Salt Lake City, UT. (June 18, 2006)

156. SLEEP ’06: Influenza, cytokines and brain organization of sleep. Salt Lake City, UT. (June 20, 2006)

157. SLEEP ’06: Cytokine regulation of sickness and health. Salt Lake City, UT. (June 21, 2006)

158. The art of good sleep: sleep and comorbid disorders, sleep and immune function. Rome, ITALY. (September 8, 2006)

159. Max Plank Institute for Psychiatry: From basic networks to individual sleep differences. Munich, GERMANY. (September 11, 2006)

160. Washington State University-Spokane Symposium – Brain Organization of Sleep: Sleeping, waking, working. Spokane, WA. (November 20, 2006)

161. Police Health and Performance Research: Biochemical regulation of sleep. Washington State University-Spokane; Spokane, WA. (November 29, 2006)

162. Sleep Disorders 2007: Neuronal organization of sleep. Las Vegas, NV. (February 2007)

163. Sleep 07: TNF alpha siRNA reduces brain TNF content and EEG delta power. Minneapolis, MN. (June 14, 2007)

164. Sleep regulation of dysregulation from molecules to flies to man. Biochemical regulation of sleep. New York Academy of Science. New York, NY (June 22, 2007)

165. 5th International Sleep Disorders Forum: Novel outcome measure of sleep, sleep loss and

insomnia. Micro-inhibitory RNAs: their involvement in sleep regulation. Chicago, IL. (September 7, 2007)

166. Sleep Physiology and Function: The role of sleep in memory and learning. National Sleep Foundation; Washington, D.C. (March 3, 2008)

167. Cytokine and Sleep Regulation in Animal Models. Symposium talk SLEEP 08. Baltimore, MD (June 11, 2008)

168. Cytokines and Brain Organization of Sleep. McLaughlin Research Institute, Great Falls, MT, (June 26, 2008)

169. Sleep and neuronal plasticity; views and hypotheses. FENS 2008 Satellite Symposium on Sleep Function. Lausanne, SWITZERLAND. (11 July 2008)

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170. Sleep and Society; The Art of Good Sleep. The ghrelin gene is required for normal integration of sleep and metabolism. Toronto, CA Sept 25, 2008.

171. Neuronal organization of sleep. Advanced Topics in Sleep Medicine, CME, Orlando, FL 16 March 2009.

172. Sleep and Immunology. Advanced Topics in Sleep Medicine, CME, Orlando, FL 16 March 2009.

173. 100 Years of humoral regulation of sleep. SLEEP09, Seattle, WA 9 June 09.

174. Local vs global control of sleep; a debate. SLEEP09, Seattle, WA 8 June 09.

175. An integrative model of cytokine involvement in sleep regulation. SLEEP09, Seattle, WA 6 June, 2009.

176. The Neurobiology of Local Sleep. 300th anniversary of the Charite-University Medicine;

New Perspective in Sleep Medicine. Berlin, GERMANY May 14, 2010.

177. Involvement of Cytokines in Slow Wave Sleep, 26th Summer School of Brain Research;

Netherlands Institute for Brain Research June 28- July 2, Amsterdam, NETHERLANDS, 2010.

178. School of Molecular Biosciences, Washington State University, 19 August 2010.

179. Finding a Research Path for the Identification of Biomarkers of Sleepiness; Biochemical regulation of sleep and implications for a sleep biomarker, Harvard Medical School, Boston, MA September 22, 2010.

180. International symposium regarding neuropeptides and behavior; Translation of Brain activity into Sleep. University of Hirosaki School of Medicine, Hirosaki, JAPAN October, 29, 2010.

181. Sleep & Cytokines Conference; Sleep and Cytokines. Children’s Hospitals & Clinics, Minneapolis, MN, Nov 15, 2010.

182. Current Topics in Sleep Medicine; American Academy of Sleep Medicine –CME, February 18, 2011 La Jolla, CA.

183. University of Pittsburgh Sleep Medicine Institute, Visiting Professorship, Pittsburgh, PA, March 14-16, 2011.

184. Sleep Medicine; World Class CME, Las Vegas, NV 13-15 Oct 2011.

185. Johnson & Johnson, Sleep Symposium, Brain Organization of Sleep, New Brunswick NJ March 17, 2011.

186. SLEEP2011 symposium; Network State Oscillations; The Building Blocks of Sleep – Introduction, Minneapolis, MN June 12, 2011.

187. SLEEP2011 symposium; Sleep and Cellular Energetics; ATP and the Purine Type 2 Receptor Affect Sleep, Minneapolis, MN June 15, 2011.

188. Multidisciplinary Dissection of Sleep Phenotypes in Animals and Humans, Institute of Advanced Studies, University of Surrey. Translation of cell activity into sleep regulatory mechanisms. Surrey, ENGLAND July, 13, 2011.

189. Sleep Disorders 2011; World Class CME. Neuronal Organization of Sleep. Las Vegas, Oct 13, 2011.

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190. SLEEP2012 symposium; Local Sleep: Basic Mechanisms and Implication for Sleep Medicine, Boston, MA June 11, 2012

191. SLEEP2012 CME; The Basics of Sleep, Boston, MA, June 10, 2012.

192. PNIS Meeting: Cytokines in local network use-dependent initiation of sleep. Stockholm, Sweden, June 7, 2013.

Symposia at which I was an Invited Observer:

1. ONR Behavioral Immunology Program; Airlie, VA. (May 1988)

2. Progress in NeuroEndocrinImmunology; Abanoterme, ITALY. (October 1988)

Seminars / Consulting Since 1981:

1. University of Wisconsin-Milwaukee; Milwaukee, WI. (1981)

2. University of Wisconsin-Parkside; Parkside, WI. (1982)

3. Case-Western Reserve Medical School; Cleveland, IL. (1982)

4. University College; London, UNITED KINGDOM. (1983)

5. Institut Pasteur; Paris, FRANCE. (1983)

6. Upjohn Company. (1983)

7. Searle Company. (1983)

8. University of Indiana Medical School; Indiana. (1984)

9. Tulane University School of Medicine. (1985)

10. Osaka Medical College; Osaka, JAPAN. (1985)

11. Institute for Protein Research; Osaka University; Osaka, JAPAN. (1985)

12. Tokyo Medical and Dental University; Tokyo, JAPAN. (1985)

13. College of Medicine, University of Tennessee-Memphis; Memphis, TN. (1985)

14. University of California-Los Angeles; Los Angeles, CA. (1985)

15. University of California-San Diego; San Diego, CA. (1985)

16. Warner-Lambert Company; Ann Arbor, MI. (1986)

17. University of Paris; Paris, FRANCE. (1986)

18. University of Illinois-Urbana; Urbana, IL. (1986)

19. University of North Carolina-Chapel Hill; Chapel Hill, NC. (1987)

20. University of Michigan-Ann Arbor; Ann Arbor, MI. (1987)

21. Monsanto Company; St. Louis, MO. (1987)

22. Walter Reed Army Hospital; Washington, DC. (1987)

23. Robert Koch Institute; Berlin, GERMANY. (1987)

24. Memphis Neuroscience Society; Memphis, TN. (1988)

25. Veterans Administration Hospital; Memphis, TN. (1988)

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26. Stanford University; Stanford, CA. (1988)

27. University of Pennsylvania; Philadelphia, PA. (1988)

28. University of Arkansas; Fayetteville, AR. (1988)


30. Mitsubishi-Kasei Institute of Life Sciences; Tokyo, JAPAN. (1988)

31. Case-Western Reserve Medical School; Cleveland, IL. (1988)

32. Glaxo Research Laboratories; Research Triangle Park, NC. (1988)

33. Harvard Medical School; Boston, MA. (1989)

34. University of Nebraska-Omaha; Omaha, NB. (1990)

35. New York University; New York, NY. (1990)


37. Osaka Bioscience Institute; Osaka, JAPAN. (1990)

38. St. Luke's/Roosevelt Hospital; New York, NY. (1991)

39. Sigma Xi lecture, University of Tennessee-Memphis; Memphis, TN. (1991)

40. Bayer Company; Wuppertal, GERMANY. (1991)

41. Istituto di Ricerche Farmacologiche; Milan, ITALY. (1991)

42. The Chicago Medical School; Chicago, IL. (1991)

43. University of Freiburg; Freiburg, GERMANY. (October 1992)

44. University of Zürich; Zürich, GERMANY. (October 1992)

45. National Institute of Immunology; New Delhi, INDIA. (September 1992)

46. Department of Medicine, University of Tennessee-Memphis; Memphis, TN. (September 1992)

47. National Institute of Mental Health. (June 2, 1993)

48. Le Moyne-Owen College; Memphis, TN. (April 1994)

49. Department of Biology, University of Delaware; Delaware, MD. (April 1994)

50. Sigma Tau Corporation; Rome, ITALY. (June 1994)

51. Universitá degli Studi; Milan, ITALY. (May 1994)

52. Osaka Bioscience Institute; Osaka, JAPAN. (October 1995)

53. Institute for Medical and Dental Engineering; Tokyo, JAPAN. (October 1995)

54. School of Medicine, University of Hirosaki; Hirosaki, JAPAN. (October 1995)

55. Yamanashi Medical College; Yamanashi, JAPAN. (October 1995)

56. Department of Pharmacology, University of Tennessee-Memphis; Memphis, TN. (November 1995)

57. College of Medicine, Pennsylvania State University; Philadelphia, PA. (April 1996)

58. University of Delaware; Newark, DE. (May 1996)

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59. ICOS Corporation; Seattle, WA. (November 1996)

60. Washington State University; Pullman, WA. (November 1996)

61. University of Puerto Rico. (December 1997)

62. Army Research Office; Research Triangle Park, NC. (April 2-4, 1998)

63. Fordham University; Bronx, NY. (March 1998)

64. Einstein Medical College; Bronx, NY. (March 1998)

65. Legacy Holliday Park Medical Center; Portland, OR. (October 1998)

66. Oregon Health Sciences University; Portland, OR. (October 1998)

67. Wake-Forrest/Bowman-Grey Medical School; Winston-Salem, NC. (October 1998)

68. University of Idaho; Moscow, ID. (November 1998)

69. Shanghai Institute of Pharmaceutical Industry; Shanghai, CHINA. (September 1999)

70. Tangdu University Hospital, Department of Neurology; Xian, CHINA. (September 1999)

71. National Academy of Military Medical Sciences; Beijing, CHINA. (October 1999)

72. Bayer A.G.; Wuppertal, GERMANY. (October 1999)

73. University of Toronto, Department of Zoology; Toronto, Quebec, CANADA. (February 2000)

74. Stanford Research Institute; Palo Alto, CA. (March 2001)

75. Max Plank Institute for Psychiatry; Munich, GERMANY. (April 2001)

76. University of Szeged; Szeged, HUNGARY. (April 2001)

77. University of Mexico; Mexico City, MEXICO. (May 2001)

78. ARCS Foundation; Seattle, WA. (December 2001)

79. School of Biological Sciences; Washington State University; Pullman, WA. (February 2002)

80. Washington Association for Biomedical Research; Washington State University; Pullman, WA. (March 2002)

81. Northwestern University; Evanston, IL. (May 2002)

82. University of Pennsylvania; Philadelphia, PA. (April 2003)

83. Medical Research Institute: Concepts for development; Spokane, WA. (June 2003)

84. Science and Technology Roundtable; Seattle, WA. (February 2004)

85. Medical College of Wisconsin: Biochemistry of sleep regulation; Department of Physiology; Milwaukee, WI. (April 2004)

86. 2nd

Annual Retreat; Center for Integrated Biotechnology: Brain organization of sleep. (September 2004)

87. Cougar Conversations: Sleep and performance; Pullman, WA. (September 2004)

88. University of Chicago: Prolactin and GHRH in sleep regulation; Chicago, IL. (September 2004)

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89. University of Puerto Rico: Biochemical regulation of sleep; San Juan, PUERTO RICO. (December 2004)

90. Department of Biology: Microbes and the brain – does sleep help host defense?; University of Puerto Rico; San Juan, PUERTO RICO. (December 2004)

91. American Institute of Biological Sciences; Walter Reed Army Institute of Research; Silver Springs, MD. (April 2005)

92. Meridian High School; Meridian, WA. (May 2005)

93. University of Washington New Faculty Presentation; Washington State University; Pullman, WA. (June 15, 2005)

94. ACE Washington Achievers Conference; Washington State University; Pullman, WA. (June 30, 2005)

95. New Faculty Orientation; Washington State University; Pullman, WA. (August 16, 2005)

96. Congressional Fact-Finding Tour; Washington State University; Spokane, WA. (August 17, 2005)

97. School of Biological Sciences; Washington State University; Pullman, WA. (September 12, 2005)

98. American Institute of Biological Sciences; Peer Review of the Air Force Research Laboratories, Bioscience and Protection Division; San Antonio, TX. (February 28-March 1, 2006)

99. University of Rome, Department of Psychology. (September 10, 2006)

100. University of Michigan, Department of Anesthesiology. (October 9, 2006)

101. Washington State University, Neuroscience Club: “Myth Busters”. (April 19, 2007)

102. Allen Institute for Brain Science: “What Sleeps?” (November 30, 2007)

103. Universitatsklinikum Schleswig-Holstein: “Brain Organization of Sleep” Lubeck, GERMANY. (December 6, 2007)

104. Pullman Science Center: “Why We Sleep”. Pullman, WA. (February 16, 2008)

105. Inspiring a New Generation of Scholars and Scientists, What sleeps and why do we sleep? Washington State University, 28 January 2009

106. Western Washington University, What sleeps and Why? Bellingham, WA 9 March 2009.

107. Amgen, Seattle, Inflammatory processes in sleep pathologies. 25 March 2009.

108. Innovators Program, Washington State University, What does sleep have to do with it; everything. 22 April 2009.

109. Golden and Diamond CVM Grads, Pullman, WA, Sleep Organization. 29 April 2009.

110. Annual WWAMI Science in Medicine Lecture, The ATP-Cytokine-Adenosine Hypothesis. Univ. of Washington School of Medicine, Seattle, WA March 3, 2010.

111. Sleep and Immunology, Department of Anesthesiology, University of Hirosaki, Hirosaki, JAPAN, Oct 30, 2010.

112. Sleep and Performance Research Center, WSU-Spokane. Brain organization of sleep. 11 Feb 2011.

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113. SLEEP2011 – Meet the Professor program; Cytokines and the Local Use-dependent Sleep Regulation Hypothesis. Minneapolis, MN June 14, 2011.

114. Surrey Sleep Research Centre. Cytokines, host defenses and sleep. Guildford, UK, July 15, 2011.

115. Riverpoint Biomedical Research Seminar Series; Translation of cell activity into a sleep regulatory mechanism. Spokane, WA, 17 October 2011.

116. University of Stockholm; Cytokines, slow wave sleep and brain organization of sleep. Stockholm, Sweden, 11 June 2013.

117. University of Helsinki; Cytokines and brain organization of sleep. Helsinki, Finland, 14 June 2013.

Grants:

Active

DATE TOTAL DIRECT COSTS

07/01/2012- Molecular mechanisms of sleep responses to viral $ 1,506,439 06/30/2017 infection. [NIH/NICHHD: R01-HD36520]. PI: J.M. Krueger; EFFORT: 20%

05/01/10- Interleukin-1: A promoter of slow-wave sleep. 1,000,121 04/30/15 [NIH/NINDS: R01-NS25378-20]. PI: J.M. Krueger; EFFORT: 20% [prior Javits Award]

Publications:

1. Krueger JM. (1974) Ph.D. Dissertation: Binding of L-alanine to a preparation from taste epithelium of the catfish Ictalurus punctatus.

2. Pappenheimer JR, Koski G, Fencl V, Karnovsky ML, Krueger JM. (1975) Extraction of sleep-promoting Factor S from cerebrospinal fluid and from brains of sleep-deprived animals. J Neurophysiol 38: 1299-1311.

3. Krueger JM, Cagan RH. (1976) Biochemical studies of taste sensation: binding of L-3(H)-

alanine to a sedimentable fraction from catfish barbel epithelium. J Biol Chem 251: 88-97.

4. Krueger JM, Sokoloff N, Botelho SY. (1976) Sialic acid in rabbit lacrimal gland fluid. Invest Ophthalmol 15: 479-481.

5. Krueger JM, Pappenheimer JR, Karnovsky ML. (1978) Sleep-promoting Factor S: purification and properties. Proc Natl Acad Sci (USA) 75: 5235-5238.

6. Krueger JM, Bacsik J, García-Arrarás J. (1980) Sleep-promoting material from human urine and its relation to Factor S from brain. Am J Physiol 238: E116-E123.

7. Pappenheimer JR, Krueger JM, Garcia-Arraras J. (1981) Properties of sleep-promoting Factor S derived from human urine. In: Advanced Physiology Science. Vol 18: “Environmental Physiology.” Obál F Jr, Benedec G (eds).

8. Krueger JM, Pappenheimer JR, Karnovsky ML. (1982) The composition of sleep-promoting factor isolated from human urine. J Biol Chem 257: 1664-1669.

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9. Krueger JM. Sleep-promoting Factor S: characterization and analogs. (1983) In: Sleep 1982. Koella WP (ed); Karger; pp 107-109.

10. Krueger JM, Pappenheimer JR, Karnovsky ML. (1982) Sleep-promoting effects of muramyl peptides. Proc Natl Acad Sci (USA) 79: 6102-6106.

11. Krueger JM, Walter J, Karnovsky M, Chedid L, Choay JP, Lefrancier P, Lederer E. (1984) Muramyl peptides: variation of somnogenic activity with structure. J Exp Med 159: 68-76.

12. Krueger JM, Walter J, Dinarello CA, Wolff SM, Chedid L. (1984) Sleep-promoting effects of endogenous pyrogen (interleukin-1). Am J Physiol 246: R994-R999.

13. Chedid L, Bahr GM, Riveau G, Krueger JM. (1984) Specific absorption with monoclonal antibodies to muramyl dipeptide of the pyrogenic and somnogenic activities of rabbit monokine. Proc Natl Acad Sci (USA) 81: 5888-5891.

14. Martin SA, Karnovsky ML, Krueger JM, Pappenheimer JR, Biemann K. (1984) Peptidoglycans as promoters of slow-wave sleep. I. Structure of sleep-promoting factor isolated from human urine. J Biol Chem 259: 12652-12658.

15. Krueger JM, Karnovsky ML, Martin SL, Pappenheimer JR, Walter J, Biemann K. (1984) Peptidoglycans as promoters of slow-wave sleep. II. Somnogenic and pyrogenic activities of some naturally occurring muramyl peptides; correlations with mass spectrometric structure determination. J Biol Chem 259: 12659-12662.

16. Krueger JM. (1985) Somnogenic activity of muramyl peptides. Trends Pharmachol Sci 6: 218-221.

17. Krueger JM, Walter J, Levin C. (1985) Factor S and related somnogens: an immune theory for slow-wave sleep. In: Brain Mechanisms of Sleep. McGinty D, et al (eds); Raven Press; pp 253-276.

18. Krueger JM. (1985) Endogenous sleep factors. In: Sleep: Neurotransmitters and Neuromodulators. Wauquier A (ed); Raven Press; pp 319-331.

19. Krueger JM. (1985) Muramyl peptides and interleukin-1 as promoters of slow wave sleep. In: Endogenous Sleep Substances and Sleep Regulation. Inoué S, Borbély AA (eds); Japan Scientific Societies Press: Tokyo, JAPAN; pp 181-192.

20. Krueger JM, Walter J, Dinarello CA, Chedid L. (1985) Induction of slow-wave sleep by interleukin-1. Progr Leukocyte Biol 2: 161-170.

21. Moldofsky H, Krueger JM, Walter J, Dinarello CA, Lue FA, Quance G, Oreopoulos DG. (1985) Sleep-promoting material extracted from peritoneal dialysate of patients with end-stage renal disease and insomnia. Peritoneal Dialysis Bull 5: 189-193.

22. Krueger JM. (1985) Interleukin-1: a promoter of slow-wave sleep. In: Neuroimmuno-modulation. Spector NH (Editor-in-Chief); IWGN: Bethesda, MD; pp 99-102.

23. Krueger JM. (1986) Muramyl peptide enhancement of slow-wave sleep. Meth Find Exp Clin Pharmacol 8: 105-110.

24. Krueger JM. Somnogenic muramyl peptides. (1986) In: Biological Properties of Peptidoglycan. Seidl HP, Schleifer KH (eds); Walter Degruyter & Co: Berlin, GERMANY; pp 329-334.

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25. Krueger JM, Shoham S. (1986) Homologies between sleep factors and hibernation triggers. In: Living in the Cold. Heller HC (ed); Elsevier Scientific Publishing Co: New York, NY; pp 235-244.

26. Krueger JM, Shoham S, Davenne D. (1986) Immune modulators as promoters of slow wave sleep. Clin Neuropharmacol 9: 462-464.

27. Walter J, Davenne D, Shoham S, Dinarello CA, Krueger JM. (1986) Brain temperature changes coupled to sleep states persist during interleukin 1-enhanced sleep. Am J Physiol 250: R96-R103.

28. Silverman DHS, Krueger JM, Karnovsky ML. (1986) Specific binding sites for muramyl peptides on murine macrophages. J Immunol 136: 2195-2201.

29. Dinarello CA, Krueger JM. (1986) Induction of interleukin-1 by synthetic and naturally occurring muramyl peptides. Fed Proc 45: 2545-2548.

30. Krueger JM, Karaszewski JW, Davenne D, Shoham S. (1986) Somnogenic muramyl peptides. Fed Proc 45: 2552-2555.

31. Krueger JM, Kubillus S, Shoham S, Davenne D. (1986) Enhancement of slow-wave sleep by endotoxin and lipid A. Am J Physiol 251: R591-R597.

32. Krueger JM, Karnovsky ML. (1987) Sleep and the immune response. Ann NY Acad Sci 496: 510-516.

33. Rosenthal RS, Krueger JM. (1987/1988) Promotion of sleep by gonococcal peptidoglycan fragments: structural requirements for somnogenic activity. In: Gonococci and Meningococci. Poolman JT, Zonen HC, Beuvery EC (eds); Kluwer Academic Publishers: Dordrecht; 1988; pp 581-590. [1987: Antonie Van Leeuwenhoek 53: 523-32.]

34. Krueger JM, Rosenthal RS, Martin SA, Walter J, Davenne D, Shoham S, Kubillus SL, Biemann K. (1987) Bacterial peptidoglycans as modulators of sleep. I. Anhydro forms of muramyl peptides enhance somnogenic potency. Brain Res 403: 249-257.

35. Krueger JM, Davenne D, Walter J, Shoham S, Kubillus SL, Rosenthal RS, Martin SA, Biemann K. (1987) Bacterial peptidoglycans as modulators of sleep. II. Effects of muramyl peptides on the structure of rabbit sleep. Brain Res 403: 258-266.

36. Krueger JM, Dinarello CA, Shoham S, Davenne D, Walter J, Kubillus S. (1987) Interferon alpha-2 enhances slow-wave sleep in rabbits. Int J Immunopharmacol 9: 23-30.

37. Shoham S, Ahokas RA, Blatteis CA, Krueger JM. (1987) Effects of muramyl dipeptide on sleep, body temperature and plasma copper after intracerebral ventricular administration. Brain Res 419: 223-228.

38. Shoham S, Davenne D, Cady AB, Dinarello CA, Krueger JM. (1987) Recombinant tumor necrosis factor and interleukin 1 enhance slow-wave sleep. Am J Physiol 253: R142-R149.

39. Davenne D, Krueger JM. (1987) Enhancement of quiet sleep in rabbit neonates by muramyl dipeptide. Am J Physiol 253: R646-R654.

40. Shoham S, Davenne D, Krueger JM. (1987) Muramyl dipeptide, amphetamine, and physostigmine: effects on sleep of rabbits. Physiol Behav 41: 179-185.

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41. Davenne D, Krueger JM. (1988) Quiet sleep in neonates is enhanced by muramyl dipeptide. In: Sleep 1986. Koella WP, Obál F Jr, Schulz H, Visser P (eds); Gustav Fisher Verlag: New York, NY; pp 178-179.

42. Krueger JM, Toth LA, Cady AB, Johannsen L, Obál F Jr. (1988) Immunomodulation and sleep. In: Sleep Peptides: Basic and Clinical Approaches. Inoué S, Schneider-Helmert D (eds); Japan Scientific Society Press: Tokyo, JAPAN/Springer-Verlag: Berlin, GERMANY; pp 95-129.

43. Johannsen L, Krueger JM. (1988) Quantitation of diaminopimelic acid in human urine. Adv Biosci 68: 445-449.

44. Shoham S, Krueger JM. (1988) Muramyl dipeptide-induced sleep and fever: effects of ambient temperature and time of injections. Am J Physiol 255: R157-R165.

45. Obál F Jr, Alföldi P, Cady AB, Johannsen L, Sáry G, Krueger JM. (1988) Growth hormone-releasing factor enhances sleep in rats and rabbits. Am J Physiol 255: R310-R316.

46. Toth LA, Krueger JM. (1988) Alteration of sleep in rabbits by Staphylococcus aureus infection. Infect Immun 56: 1785-1791.

47. Krueger JM, Majde JA, Blatteis CA, Endsley J, Ahokas RA, Cady AB. (1988) Polyriboinosinic:polyribocytidylic acid (Poly I:C) enhances rabbit slow-wave sleep. Am J Physiol 255: R748-R755.

48. Opp MR, Obál F Jr, Krueger JM. (1988) Effects of -MSH on sleep, behavior, and brain temperature: interactions with IL1. Am J Physiol 255: R914-R922.

49. Krueger JM, Toth LA, Johannsen L, Obál F Jr, Opp MR, Cady AB. (1988) Enhancement of mammalian sleep by immune modulators. In: Advances in Immunopharmacology 4. Hadden et al (eds); Pergamon Press: New York, NY; pp 55-63.

50. Krueger JM, Johannsen L. (1988) Bacterial products, cytokines and sleep. In: Molecular Mimicry in Health and Disease. Lernmark S, Dyrberg T, Terenius L, Hökfelt B (eds); Elsevier: Amsterdam, NETHERLANDS; pp 35-46.

51. Walter JS, Meyers P, Krueger JM. (1989) Microinjection of interleukin-1 into brain: separation of sleep and fever responses. Physiol Behav 45: 169-176.

52. Obál F Jr, Opp MR, Cady A, Johannsen L, Alföldi P, Krueger JM. (1989) Links between neuroendocrine processes and sleep regulation. In: Sleep ‘88. Koella WP (ed); Fischer: Stüttgart, GERMANY; pp 74-76.

53. Opp MR, Obál F Jr, Krueger JM. (1989) Alpha-MSH inhibits normal and IL1-induced excess sleep in rabbits. In: Sleep ‘88. Koella WP (ed); Fischer: Stüttgart, GERMANY; pp 145-146.

54. Shoham S, Blatteis CM, Krueger JM. (1989) Effects of preoptic area lesions on muramyl dipeptide-induced sleep and fever. Brain Res 476: 396-399.

55. Cady AB, Kotani S, Shiba T, Kusumoto S, Krueger JM. (1989) Somnogenic activities of synthetic lipid A. Infect Immun 57: 396-403.

56. Obál F Jr, Opp MR, Cady AB, Johannsen L, Krueger JM. (1989) Prolactin, vasoactive intestinal peptide, and peptide histidine methionine elicit selective increases in REM sleep in rabbits. Brain Res 490: 292-300.

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57. Toth LA, Krueger JM. (1989) Hematologic effects of exposure to three infective agents in rabbits. J Am Vet Med Assoc 195: 981-986.

58. Krueger JM, Obál F Jr, Johannsen L, Cady AB, Toth LA. (1989) Endogenous slow wave sleep substances. In: Slow Wave Sleep: Physiological, Pathophysiological and Functional Aspects. Wauquier A, Dugovic C, Radulovacki M (eds); Raven Press: New York, NY; pp 75-90.

59. Shibata M, Blatteis CM, Krueger JM, Obál F Jr, Opp MR. (1989) Pyrogenic, inflammatory, and somnogenic responses to cytokines: differential modes of action. In: Thermoregulation: Research and Clinical Applications. Lomax P, et al (eds); Karger: Basel; pp 69-73.

60. Toth LA, Krueger JM. (1989) Effects of microbial challenge on sleep in rabbits. FASEB-J 3: 2062-2066.

61. Krueger JM. (1989) No simple slumber. The Sciences May/June Issue: pp 36-41.

62. Opp MR, Obál F Jr, Cady AB, Johannsen L, Krueger JM. (1989) Interleukin-6 is pyrogenic, but not somnogenic. Physiol Behav 45: 1069-1072.

63. Opp MR, Obál F Jr, Krueger JM. (1989) Corticotropin-releasing factor attenuates interleukin 1-induced sleep and fever in rabbits. Am J Physiol 257: R528-R535.

64. Krueger JM, Obál F Jr, Opp MR, Johannsen L, Cady AB, Toth LA. (1989) Immune response modifiers and sleep. In: Interactions Among Central Nervous System, Neuroendocrine and Immune Systems. Hadden JW, Masek K, Nistico G (eds); Pythagora Press: Rome, ITALY; pp 323-350.

65. Cady AB, Riveau G, Chedid L, Dinarello CA, Johannsen L, Krueger JM. (1989) Interleukin-1-induced sleep and febrile responses differentially altered by a muramyl dipeptide derivative. Int J Immunopharmac 11: 887-893.

66. Johannsen L, Rosenthal RS, Martin SA, Cady AB, Obál F Jr, Guinand M, Krueger JM. (1989) Somnogenic activity of O-acetylated and dimeric muramyl peptides. Infect Immun 57: 2726-2732.

67. Krueger JM, Johannsen L. (1989) Bacterial products, cytokines and sleep. J Rheumato 16: 52-57.

68. Krueger JM, Obál F Jr, Opp MR, Toth LA, Johannsen L, Cady AB. (1990) Somnogenic cytokines and models concerning their effects on sleep. Yale J Biol Med 63: 157-172.

69. Johannsen L, Toth LA, Rosenthal RS, Opp MR, Obál F Jr, Cady AB, Krueger JM. (1990) Somnogenic, pyrogenic, and hematologic effects of bacterial peptidoglycan. Am J Physiol 259: R182-R186.

70. Toth LA, Krueger JM. (1990) Somnogenic, pyrogenic, and hematologic effects of experimental pasteurellosis in rabbits. Am J Physiol 258: R536-R542.

71. Krueger JM. (1990) Somnogenic activity of immune response modifiers. Trends Pharma Sci 11: 122-126.

72. Krueger JM, Majde JA. (1990) Sleep as a host defense: its regulation by microbial products and cytokines. Clin Immunol Immunopathol 57: 188-199.

73. Krueger JM, Toth LA, Johannsen L, Opp MR. (1990) Infectious disease and sleep: involvement of neuroendocrine-neuroimmune mechanisms. Int J Neurosci 51: 359-362.

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74. Krueger JM, Obál F Jr, Opp MR, Cady AB, Johannsen L, Toth LA, Majde JA. (1990) Putative sleep neuromodulators. In: Sleep and Biological Rhythms. Montplaisir J, Godbout R (eds); Oxford Press: New York, NY; pp 163-185.

75. Krueger JM, Obál F Jr, Toth LA, Johannsen L, Cady AB, Opp M. (1990) Sleep factors: models concerning their multiple interactions and specificity for sleep. In: Endogenous Sleep Factors. Inoué S, Krueger JM (eds); SPB Academic Publishing; pp 19-29.

76. Obál F Jr, Opp MR, Sáry G, Krueger JM. (1990) Endocrine mechanisms in sleep regulation. In: Endogenous Sleep Factors. Inoué S, Krueger JM (eds); SPB Academic Publishing; pp 109-120.

77. Krueger JM, Obál F Jr, Johannsen L, Opp MR, Toth LA, Cady AB. (1990) Endogenous sleep factors: relationships to physiological variables. In: Sleep and Respiration. Issa FG, Suratt PM, Remmers JE (eds); Wiley Liss: New York, NY; pp 1-8. Prog Clin Biol Res 345: 1-8.

78. Krueger JM, Opp MR, Toth LA, Johannsen L, Kapás L. (1990) Cytokines and sleep. In: Current Topics in Neuroendocrinology; Vol 10: “Behavioral Aspects of Neuroendocrinology.” Ganten D, Pfaff D (eds); Springer-Verlag: Berlin, GERMANY; pp 243-261.

79. Opp MR, Obál F Jr, Payne L, Krueger JM. (1990) Responsiveness of rats to interleukin-1: effects of monosodium glutamate treatment of neonates. Physiol Behav 48: 451-457.

80. Obál F Jr, Opp MR, Cady AB, Johannsen L, Postlethwaite AE, Poppleton HM, Seyer JM,

Krueger JM. (1990 Interleukin 1 and an interleukin 1 fragment are somnogenic. Am J Physiol 259: R439-R446.

81. Opp MR, Krueger JM. (1990) IL-6: A pyrogenic cytokine that is not somnogenic. In: The Physiological and Pathological Effects of Cytokines. Kluger M, Oppenheim JJ, Dinarello CA, Powanda M (eds); Wiley-Liss, Inc; pp 319-324.

82. Krueger JM, Opp MR, Toth LA, Kapás L. (1990) Immune regulation, hormones, and sleep. In: Sleep ‘90. Horne J (ed); Pontenagel Press: Bochum; pp 371-374.

83. Toth LA, Krueger JM. (1990) Infectious disease, cytokines and sleep. In: The Diencephalon and Sleep. Mancia M (ed); Raven Press: New York, NY; pp 331-341.

84. Opp MR, Obál F Jr, Krueger JM. (1991) Interleukin-1 alters rat sleep: temporal and dose-related effects. Am J Physiol 260: R52-R58.

85. Johannsen L, Wecke J, Obál F Jr, Krueger JM. (1991) Macrophages produce somnogenic and pyrogenic muramyl peptides during the digestion of staphylococci. Am J Physiol 260: R126-R133.

86. Majde JA, Brown RK, Jones MW, Dieffenbach CW, Maitra N, Krueger JM, Cady AB, Smitka CW, Maassab HF. (1991) Detection of toxic viral-associated double-stranded RNA (dsRNA) in influenza-infected lung. Microbial Pathogen 10: 105-115.

87. Opp MR, Krueger JM. (1991) Interleukin 1 receptor antagonist blocks interleukin 1-induced sleep and fever. Am J Physiol 260: R453-R457.

88. Kapás L, Payne l, Obál F Jr, Opp MR, Johannsen L, Krueger JM. (1991) Sleep in diabetic rats: effects of interleukin 1. Am J Physiol 260: R995-R999.

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89. Kapás L, Obál F Jr, Farkas I, Payne LC, Sáry G, Rubicsek G, Krueger JM. (1991) Cholecystokinin promotes sleep and reduces food intake in diabetic rats. Physiol Behav 50: 417-420.

90. Obál F Jr, Payne L, Kapás L, Opp MR, Krueger JM. (1991) Inhibition of growth hormone-releasing hormone suppresses both sleep and growth hormone secretion in the rat. Brain Res 557: 149-153.

91. Johannsen L, Labischinski H, Krueger JM. (1991) Somnogenic activity of pseudomurein in rabbits. Infection Immunity 59: 2502-2504.

92. Krueger JM, Johannsen L, Toth LA, Opp MR, Kapás L. (1991) CNS mechanisms for sleep responses to microbial challenge. In: Peripheral Signaling of the Brain. Neural-immune and Cognitive Function. (Proceedings of the 6

th International Symposium on

Neuronal Control of Bodily Function: Basic and Clinical Aspects.) Frederickson RCA, McGaugh JL, Felten DL (eds); Hogrefe & Huber Publishers: Toronto, Quebec, CANADA; pp 179-192.

93. Krueger JM, Toth LA, Obál F Jr, Opp MR, Kimura-Takeuchi M, Kapás L. (1991) Infections, cytokines and sleep. In: Sleep Hormones and Immunological System. Smirne S (ed); Masson Editor: Milano, ITALY; pp 59-70.

94. Hong L, Johannsen L, Krueger JM. (1991) Modulation of human leukocyte antigenDR

expression in glioblastoma cells by interferon gamma and other cytokines. J Neuroimmunol 35: 139-152.

95. Kapás L, Obál F Jr, Opp MR, Johannsen L, Krueger JM. (1991) Intraperitoneal injection of cholecystokinin elicits sleep in rabbits. Physiol Behav 50: 1241-1244.

96. Obál F Jr, Payne L, Opp MR, Kapás L, Alföldi P, Krueger JM. (1991) Hypothalamic-releasing hormones in sleep regulation. In: Sleep Hormones and Immunological System. Smirne S (ed); Masson Editor: Milano, ITALY; pp 91-98.

97. Krueger JM, Opp MR, Kapás L, Kimura-Takeuchi M, Toth LA. (1992) Muramyl peptides and interleukin-1 in sleep regulation. In: Endocrine and Nutritional Control of Basic Biological Functions. Murison R (ed); Hogrefe & Huber Publishers: Toronto, Quebec, CANADA; pp 343-349.

98. Opp MR, Krueger JM. (1992) Interleukin-1 involvement in the regulation of sleep. In: Interleukin-1 in the Brain. Rothwell N, Dantzer R (eds); Manchester University Press: Manchester; pp 151-172.

99. Krueger JM, Kapás L, Opp MR, Obál F Jr. (1992) Prostaglandins E2 and D2 have little effect on rabbit sleep. Physiol Behav 51: 481-485.

100. Payne L, Obál F Jr, Opp MR, Krueger JM. 1992. Stimulation and inhibition of growth

hormone secretion by interleukin-1: the involvement of growth hormone-releasing hormone. Neuroendocrinology 56: 118-123.

101. Opp MR, Postlethwaite AE, Seyer JM, Krueger JM. (1992) Interleukin 1 receptor antagonist blocks somnogenic and pyrogenic responses to an interleukin 1 fragment. PNAS 89: 3726-3730.

102. Kapás L, Krueger JM. (1992) Tumor necrosis factor- induces sleep, fever, and anorexia. Am J Physiol 263: R703-R707.

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103. Kapás L, Hong L, Cady AB, Opp MR, Postlethwaite AE, Seyer JM, Krueger JM. (1992)

Somnogenic, pyrogenic, and anorectic activities of tumor necrosis factor- and TNF- fragments. Am J Physiol 263: R708-R715.

104. Kimura-Takeuchi M, Majde JA, Toth LA, Krueger JM. (1992) Influenza virus-induced changes in rabbit sleep and acute phase responses. Am J Physiol 263: R1115-R1121.

105. Obál F Jr, Payne L, Opp MR, Alföldi P, Kapás L, Krueger JM. (1992) Growth hormone-releasing hormone antibodies suppress sleep and prevent enhancement of sleep after sleep deprivation. Am J Physiol 263: R1078-R1085.

106. Toth LA, Gardiner TW, Krueger JM. (1992) Modulation of sleep by cortisone in normal and bacterially infected rabbits. Am J Physiol 263: R1339-R1346.

107. Payne LC, Krueger JM. (1992) Interactions of cytokines with the hypothalamic-pituitary axis. J Immunother 12: 171-173.

108. Obál F Jr, Kacsóh B, Alföldi P, Payne L, Markovic O, Grosvenor C, Krueger JM. (1992) Antiserum to prolactin decreases rapid eye movement sleep (REM Sleep) in the male rat. Physiol Behav 52: 1063-1068.

109. Kimura-Takeuchi M, Majde JA, Toth LA, Krueger JM. (1992) The role of double-stranded RNA in the induction of the acute-phase response in an abortive influenza virus infection model. J Infect Dis 166: 1266-1275.

110. Hong L, Imeri L, Opp MR, Postlethwaite AE, Seyer JM, Krueger JM. (1993) Intercellular

adhesion molecule-1 expression induced by interleukin (IL)-1 or an IL-1 fragment is blocked by an IL-1 receptor antagonist and a soluble IL-1 receptor. J Neuroimmunol 44: 163-170.

111. Toth LA, Tolley EA, Krueger JM. (1993) Sleep as a prognostic indicator during infectious disease in rabbits. Proc Soc Exper Biol Med 203: 179-192.

112. Krueger JM, Obál F Jr. (1993) Growth hormone-releasing hormone and interleukin-1 in sleep regulation. FASEB J 7: 645-652.

113. Krueger JM, Obál F Jr. (1993) A neuronal group theory of sleep function. J Sleep Res 2: 63-69.

114. Imeri L, Opp MR, Krueger JM. (1993) An IL-1 receptor and an IL-1 receptor antagonist attenuate muramyl dipeptide- and IL-1-induced sleep and fever. Am J Physiol 265: R907-R913.

115. Krueger JM. (1993) Chemistry of sleep, sleep factors. In: Encyclopedia of Sleep and Dreaming. Carskadon M (ed); MacMillian Publishing Company: New York, NY; pp 108-109.

116. Krueger JM, Kapás L, Kimura-Takeuchi M, Opp MR. (1993) Somnogenic cytokines: methods and overview. In: Methods in Neuroscience; Vol 17, Part B: “Neurobiology of Cytokines”. DeSouza ED (ed); Academic Press: Orlando, FL; pp 111-129.

117. Kapás L, Obál F Jr, Krueger JM. (1993) Humoral regulation of sleep. In: International Review of Neurobiology; Vol 35. Bradley RJ, Harris RA (eds); Academic Press; pp 131-160.

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118. Krueger JM, Opp MR, Kapás L, Obál F Jr. (1993) Interleukin-1 in sleep regulation. In: Sleep-Wakefulness. Mohan Kumar V, Mallick HN, Nayar U (eds); Wiley Eastern Ltd: New Delhi, INDIA; pp 11-15.

119. Toth LA, Kimura-Takeuchi M, Krueger JM. (1993) Hypersomnia during infectious disease. In: Sleep-Wakefulness. Mohan Kuman V, Mallick HN, Nayar U (eds); Wiley Eastern Ltd: New Delhi, INDIA; pp 155-159.

120. Obál F Jr, Fang J, Payne L, Krueger JM. (1993) Interactions between interleukin-1 and growth hormone-releasing hormone in promoting sleep. In: Environment and Physiology. Mallick BN, Singh R (eds); Narosa Publishing House: New Delhi, INDIA; pp 180-185.

121. Krueger JM, Toth LA, Shapiro C. (1993) Sleep, the immune response and infectious disease. In: ABC of Sleep Disorders. BMJ Publishing Group: London, UNITED KINGDOM; pp 55-58.

122. Payne L, Obál F Jr, Krueger JM. (1993) Hypothalamic releasing hormones mediating the effects of interleukin-1 on sleep. J Cell Biochem 53: 309-313.

123. Kapás L, Shibata M, Kimura M, Krueger JM. (1994) Inhibition of nitric oxide synthesis suppresses sleep in rabbits. Am J Physiol 266: R151-R157.

124. Opp MR, Krueger JM. (1994) Anti-interleukin-1 reduces sleep and sleep rebound after sleep deprivation in rats. Am J Physiol 266: R688-R695.

125. Opp MR, Krueger JM. (1994) Interleukin-1 is involved in responses to sleep deprivation in the rabbit. Brain Res 639: 57-65.

126. Johannsen L, Obál F Jr, Kapás L, Kovalzon V, Krueger JM. (1994) Somnogenic activity of muramyl peptide-derived immune adjuvants. Int J Immunopharm 16: 109-116.

127. Toth LA, Tolley EA, Broady R, Blakely B, Krueger JM. (1994) Sleep during experimental trypanosomiasis in rabbits. Proc Soc Exper Med Biol 205: 174-181.

128. Krueger JM, Toth LA, Floyd R, Fang J, Kapás L, Bredow S, Obál F Jr. (1994) Sleep, microbes and cytokines. Neuroimmunomodulation 1: 100-109.

129. Kimura M, Majde JA, Toth LA, Opp MR, Krueger JM. (1994) Somnogenic effects of rabbit and human recombinant interferons in rabbits. Am J Physiol 267: R53-R61.

130. Obál F Jr, Payne L, Kacsóh B, Opp MR, Kapás L, Grosvenor CE, Krueger JM. (1994) Involvement of prolactin in the REM sleep-promoting activity of systemic vasoactive intestinal peptide (VIP). Brain Res 645: 143-149.

131. Krueger JM, Toth LA. (1994) Cytokines as regulators of sleep. Ann NY Acad Sci 739: 299-310.

132. Krueger JM, Obál F Jr. (1994) Sleep factors. In: Sleep and Breathing. Saunders NA, Sullivan CE (eds); Marcel Dekker, Inc: New York, NY; pp 79-112.

133. Krueger JM, Kovalzon VM. (1994) Sleep: modern thoughts on an ancient enigma. Sci Humanity (in Russian); pp 50-57.

134. Kimura M, Toth LA, Agostini H, Cady AB, Majde JA, Krueger JM. (1994) Comparison of acute-phase responses induced in rabbits by the lipopolysaccharide of endotoxin and the double-stranded RNA polyriboinosinic:poly-ribocytidylic acid. Am J Physiol 267: R1596-R1606.

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135. Bredow S, Kacsóh B, Obál F Jr, Fang J, Krueger JM. (1994) Increase of prolactin mRNA in the rat hypothalamus after intracerebroventricular injection of VIP or PACAP. Brain Res 660: 301-308.

136. Kapás L, Fang J, Krueger JM. (1994) Inhibition of nitric oxide synthesis inhibits rat sleep. Brain Res 664: 189-196.

137. Krueger JM, Toth LA. (1994) Cytokines and sleep mechanisms. In: Advances in Psychoneuroimmunology. Szelenyi J, Berczi I (eds); Plenum Press: New York, NY; pp 161-172.

138. Krueger JM, Majde JA. (1994) Microbial products and cytokines in sleep and fever regulation. Crit Rev Immunol 14: 355-379.

139. Krueger JM, Obál F Jr. (1994) Sleep substances: an unavoidable fact of neurobiology. World Fed Sleep Res Soc Newslett 3: 10-15.

140. Kovalzon VM, Obál F Jr, Johannsen L, Krueger JM, Andronova TM. (1994) The muramyl peptides and sleep. Sechenov Physiol J (in Russian) 80: 44-50.

141. Krueger JM, Obál F Jr, Kapás L, Fang J. (1995) Brain organization and sleep function. Behav Brain Res 69: 177-185.

142. Obál F Jr, Fang J, Payne LC, Krueger JM. (1995) Growth hormone-releasing hormone (GHRH) mediates the sleep promoting activity of interleukin-1 (IL1) in rats. Neuroendocrinology 61: 559-565.

143. Kapás L, Shibata M, Krueger JM. (1995) The role of cytokines in sleep, fever and anorexia. In: Human Cytokines: Their Role in Disease and Therapy. Aggarwal BB, Puri RK (eds); Blackwell Scientific Publications, Inc: Cambridge, MA; pp 305-314.

144. Krueger JM. (1995) Sleep and the immune system. Sleep Med Rev Jan/Feb III; pp 1-2.

145. Krueger JM, Karnovsky ML. (1995) Sleep as a neuroimmune phenomenon: a brief historical perspective. Adv Neuroimmunol 5: 5-12.

146. Knefati M, Somogyi C, Kapás L, Bourcier T, Krueger JM. (1995) Acidic fibroblast growth factor (FGF), but not basic FGF, induces sleep and fever in rabbits. Am J Physiol 269: R87-R91.

147. Krueger JM, Majde JA. (1995) Cytokines and sleep. Int Arch Allergy Immunol 106: 97-100.

148. Krueger JM, Takahashi S, Kapás L, Bredow S, Roky R, Fang J, Floyd R, Renegar K, Guha-Thakurta N, Novitsky S, Obál F Jr. (1995) Cytokines in sleep regulation. Adv Neuroimmunol 5: 171-188.

149. Fang J, Payne L, Krueger JM. (1995) Pituitary adenylate cyclase activating polypeptide enhances rapid eye movement sleep in rats. Brain Res 686: 23-28.

150. Roky R, Obál F Jr, Valatx JL, Bredow S, Fang J, Pagano LP, Krueger JM. (1995) Prolactin and rapid eye movement sleep. Sleep 18: 536-542.

151. Takahashi S, Kapás L, Fang J, Krueger JM. (1995) Anti-tumor necrosis factor antibody suppresses sleep in rats and rabbits. Brain Res 690: 241-244.

152. Fang J, Sanborn CK, Renegar KB, Majde JA, Krueger JM. (1995) Influenza viral infections enhance sleep in mice. Proc Soc Exp Med Biol 210: 242-252.

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153. Toth LA, Krueger JM. (1995) Lighting conditions alter Candida albicans-induced sleep responses. Am J Physiol 269: R1441-R1447.

154. Takahashi S, Tooley D, Kapás L, Fang J, Seyer JM, Krueger JM. (1995) Inhibition of tumor necrosis factor suppresses sleep in rabbits. Pflügers Arch 431: 155-160.

155. Kapás L, Krueger JM. (1996) Interactive effects of cytokines in the brain: sleep, fever and anorexia. In: The Physiology of Immunity. Marsh JA, Kendall MD (eds); CRC Press: Boca Raton, FL; pp 157-167.

156. Obál F Jr, Floyd R, Kapás L, Bodosi B, Krueger JM. (1996) Effects of systemic GHRH on sleep in intact and hypophysectomized rats. Am J Physiol 270: E230-E237.

157. Ayers NA, Kapás L, Krueger JM. (1996) Circadian variation of nitric oxide synthase activity and cytosolic protein levels in rat brain. Brain Res 707: 127-130.

158. Kapás L, Obál F Jr, Book AA, Schweitzer JB, Wiley RG, Krueger JM. (1996) The effects of immunolesions of nerve growth factor-receptive neurons by 192-IgG saporin on sleep. Brain Res 712: 53-59.

159. Takahashi S, Kapás L, Seyer JM, Wang Y, Krueger JM. (1996) Inhibition of tumor necrosis factor attenuates physiological sleep in rabbits. NeuroReport 7: 642-646.

160. Fincher EF, Johannsen L, Kapás L, Takahashi S, Krueger JM. (1996) Microglia digest Staphylococcus aureus into low molecular weight biologically active compounds. Am J Physiol 271: R149-R156.

161. Takahashi S, Kapás L, Fang J, Wang Y, Seyer JM, Krueger JM. (1996) An interleukin-1 receptor fragment inhibits spontaneous sleep and muramyl dipeptide-induced sleep in rabbits. Am J Physiol 271: R101-R108.

162. Shibata M, Parfenova H, Zuckerman SL, Seyer JM, Krueger JM, Leffler CW. (1996)

Interleukin-1 peptides induce cerebral pial arteriolar dilation in anesthetized newborn pigs. Am J Physiol 270: R1044-R1050.

163. Fang J, Tooley D, Gatewood C, Renegar KB, Majde JA, Krueger JM. (1996) Differential effects of total and upper airway influenza viral infection on sleep in mice. Sleep 19: 337-342.

164. Krueger JM, Takahashi S, Fang J. (1996) Cytokines as regulators of sleep. In: Physiological Basis of Occupational Heath: Stressful Environments. Shiraki K, Youref MK (eds); SPB Academic Publishing: Amsterdam, NETHERLANDS; pp 267-278.

165. Takahashi S, Kapás L, Krueger JM. (1996) A tumor necrosis factor (TNF) receptor

fragment attenuates TNF- and muramyl dipeptide-induced sleep and fever in rabbits. J Sleep Res 5: 106-114.

166. Fincher EF, Pabst MJ, Krueger JM. (1996) Neutrophils but not monocytes or microglia degrade interleukin-1. Neuroimmunomodulation 3: 82-86.

167. Krueger JM. (1996) Cytokine involvement in sleep responses to infection and physiological sleep. In: Cytokines in the Nervous System. Rothwell NJ (ed); Landes Publishing: Austin, TX; pp 41-71.

168. Bredow S, Taishi P, Obál F Jr, Guha-Thakurta N, Krueger JM. (1996) Hypothalamic growth hormone-releasing hormone (GHRH) mRNA varies across the day in rats. NeuroReport 7: 2501-2505.

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169. Kapás L, Krueger JM. (1996) Nitric oxide donors SIN-1 and SNAP promote non-rapid eye movement sleep in rats. Brain Res Bull 41: 293-298.

170. Zhang J, Obál F Jr, Fang J, Collins BJ, Krueger JM. (1996) Non-rapid eye movement sleep is suppressed in transgenic mice with a deficiency in the somatotropic system. Neurosci Lett 220: 97-100.

171. Krueger JM, Takahashi S. (1997) Thermoregulation and sleep: closely linked but separable. Ann NY Acad Sci 813: 281-286.

172. Krueger JM, Obál F Jr. (1997) Sleep regulatory substances. In: Monographs in Clinical Neuroscience. Schwartz WJ (ed); Karger: Basel; 15: 175-194.

173. Ayers NA, Kapás L, Krueger JM. (1997) The inhibitory effects of N-nitro-L-arginine

methyl ester on nitric oxide synthase activity vary among brain regions in vivo, but not in vitro. Neurochem Res 22: 81-86.

174. Takahashi S, Krueger JM. (1997) Inhibition of tumor necrosis factor prevents warming-induced sleep responses in rabbits. Am J Physiol 41: R1325-R1329.

175. Taishi P, Bredow S, Guha-Thakurta N, Obál F Jr, Krueger JM. (1997) Diurnal variations

of interleukin-1 mRNA and -actin mRNA in rat brain. J Neuroimmunol 75: 69-74.

176. Krueger JM, Fang J. (1997) Cytokines in sleep regulation. In: Sleep and Sleep Disorders: From Molecule to Behavior. Hayaishi O, Inoue S (eds); Academic Press; pp 261-277.

177. Obál F Jr, Bodosi B, Szilagyi A, Kacsóh B, Krueger JM. (1997) Antiserum to growth hormone suppresses sleep in the rat. Neuroendocrinology 66: 9-16.

178. Obál F Jr, Kacsóh B, Bredow S, Guha-Thakurta N, Krueger JM. (1997) Sleep in rats rendered chronically hyperprolactinemic with anterior pituitary grafts. Brain Res 755: 130-136.

179. Floyd RA, Krueger JM. (1997) Diurnal variations of TNF in the rat brain. NeuroReport 8: 915-918.

180. Krueger JM. (1997) Sleep and immune function. Karger Gazette (April) No 61: 6-8.

181. Takahashi S, Fang J, Kapás L, Wang Y, Krueger JM. (1997) Inhibition of brain interleukin-1 attenuates sleep rebound after sleep deprivation in rabbits. Am J Physiol 273: R677-R682.

182. Fang J, Wang Y, Krueger JM. (1997) Mice lacking the TNF 55-kD receptor fail to sleep

more after TNF treatment. J Neurosci 17: 5949-5955.

183. Beranek L, Obál F Jr, Taishi P, Bodosi B, Laczi F, Krueger JM. (1997) Changes in rat sleep after single and repeated injections of the long-acting somatostatin analog, octreotide. Am J Physiol 42: R1484-R1491.

184. Hansen MK, Krueger JM. (1997) Subdiaphragmatic vagotomy blocks the sleep and

fever-promoting effects of interleukin-1. Am J Physiol 273: R1246-R1253.

185. Bredow S, Taishi P, Guha-Thakurta N, Obál F Jr, Krueger JM. (1997) Diurnal variations

of tumor necrosis factor- mRNA and -tubulin mRNA in rat brain. J NeuroImmunoMod 4: 84-90.

KRUEGER, James M.

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186. Chen Z, Krueger JM. (1998) Sleep regulatory substances: changes in mRNA expression linked to sleep. In: Molecular Regulation of Conscious States. Lydic R (ed); CRC Press: Boca Raton, FL; pp 33-44.

187. Hansen M, Kapás L, Fang J, Krueger JM. (1998) Cafeteria diet-induced sleep is blocked by subdiaphragmatic vagotomy in rats. Am J Physiol 274: R168-R174.

188. Kapás L, Hansen MK, Chang H-Y, Krueger JM. (1998) Vagotomy attenuates but does not prevent somnogenic and febrile effects of lipopolysaccharide in rats. Am J Physiol 274: R406-R411.

189. Fang J, Wang Y, Krueger JM. (1998) The effects of interleukin-1 on sleep are mediated by the type I receptor. Am J Physiol 274: R655-R660.

190. Renegar KB, Floyd R, Krueger JM. (1998) Effect of sleep deprivation on serum influenza-specific IgG. Sleep 21: 19-24.

191. Kimura M, Kapás L, Krueger JM. (1998) Oxidized glutathione promotes sleep in rabbits. Brain Res Bull 45: 545-548.

192. Obál F Jr, Kapás L, Bodosi B, Krueger JM. (1998) Changes in sleep in response to intracerebral injection of insulin-like growth factor-1 (IGF-1) in the rat. Sleep Res Online 2: 87-91.

193. Hansen MK, Taishi P, Chen Z, Krueger JM. (1998) Vagotomy blocks the induction of

interleukin-1 mRNA in the brain of rats in response to systemic interleukin-1. J Neurosci 18: 2247-2253.

194. Kushikata T, Takahashi S, Wang Y, Fang J, Krueger JM. (1998) An interleukin-1 receptor fragment blocks ambient temperature-induced increases in brain temperature but not sleep in rabbits. Neurosci Lett 244: 125-128.

195. Hansen MK, Taishi P, Chen Z, Krueger JM. (1998) Cafeteria-feeding induces interleukin-

1 mRNA expression in rat liver and brain. Am J Physiol 43: R1734-R1739.

196. Renegar KB, Floyd RA, Krueger JM. (1998) Effects of short-term sleep deprivation on murine immunity to influenza virus in young adult and senescent mice. Sleep 21: 241-248.

197. Krueger JM, Fang J, Hansen MK, Zhang J, Obál F Jr. (1998) Humoral regulation of sleep. News Physiol Sci 13: 189-194.

198. Kushikata T, Fang J, Chen Z, Wang Y, Krueger JM. (1998) Epidermal growth factor (EGF) enhances spontaneous sleep in rabbits. Am J Physiol 275: R509-R514.

199. Obál F Jr, Kapás L, Krueger JM. (1998) Albumin enhances sleep in the young rat. Physiol Behav 64: 261-266.

200. Hansen MK, Krueger JM. (1998) Subdiaphragmatic vagotomy does not block sleep deprivation-induced sleep in rats. Physiol Behav 64: 361-365.

201. Taishi P, Chen Z, Obál F Jr, Zhang J, Hansen M, Fang J, Krueger JM. (1998) Sleep-

associated changes in interleukin-1 mRNA in the brain. J Interferon Cytokine Res 18: 793-798.

202. Krueger JM, Fang J, Taishi P, Chen Z, Kashikata T, Gardi J. (1998) Sleep: a

physiological role for IL1 and TNF. Ann NY Acad Sci 856: 148-159.

KRUEGER, James M.

-38-

203. Kushikata T, Fang J, Wang Y, Krueger JM. (1998) Interleukin-4 inhibits spontaneous sleep in rabbits. Am J Physiol 275: R1185-R1191.

204. Krueger JM. (1998) Animal models of sleep. J Musculoskeletal Pain 6: 87-92.

205. Majde JA, Guha-Thakurta N, Chen Z, Bredow S, Krueger JM. (1998) Spontaneous release of stable viral double-stranded RNA into the extracellular medium by influenza virus-infected MDCK epithelial cells: implications for the viral acute phase response. Arch Virol 143: 2371-2380.

206. Zhang J, Chen Z, Taishi P, Obál F Jr, Fang J, Krueger JM. (1998) Sleep deprivation increases rat hypothalamic growth hormone-releasing hormone mRNA. Am J Physiol 275: R1755-R1761.

207. Krueger JM, Fang J. (1999) Cytokines and sleep regulation. In: Handbook of Behavioral State Control. Lydic R, Baghdoyan HA (eds); CRC Press: Boca Raton, FL; pp 609-622.

208. Fang J, Bredow S, Taishi P, Majde JA, Krueger JM. (1999) Synthetic influenza viral double-stranded RNA induces an acute phase response in rabbits. J Med Virol 57: 198-203.

209. Zhang J, Obál F Jr, Zheng T, Fang J, Taishi P, Krueger JM. (1999) Intrapreoptic microinjection of GHRH or its antagonist alters sleep in rats. J Neurosci 19: 2187-2194.

210. Obál F Jr, Krueger JM. (1999) Hormones and REM sleep. In: Rapid Eye Movement Sleep. Mallick BN, Inoue S (eds); Narosa Publishers: New Delhi, INDIA; pp 233-247.

211. Takahashi S, Kapás L, Fang J, Krueger JM. (1999) Somnogenic relationships between tumor necrosis factor and interleukin-1. Am J Physiol 276: R1132-R1140.

212. Kushikata T, Fang J, Krueger JM. (1999) Brain-derived neurotrophic factor enhances spontaneous sleep in rats and rabbits. Am J Physiol 276: R1334-1338.

213. Takahashi S, Krueger JM. (1999) Nerve growth factor enhances sleep in rabbits. Neurosci Lett 264: 149-152.

214. Krueger JM, Floyd RA, Fang J. (1999) Relationships between sleep and immune function. In: Regulation of Sleep and Circadian Rhythms. Turek FW, Zee PC (eds); Marcel Dekker, Inc: New York, NY; pp 427-464.

215. Chen Z, Gardi J, Kushikata T, Fang J, Krueger JM. (1999) Nuclear factor kappa B-like activity increases in murine cerebral cortex after sleep deprivation. Am J Physiol 45: R1812-R1818.

216. Krueger JM, Obál F Jr, Fang J. (1999) Humoral regulation of physiological sleep; cytokines and GHRH. J Sleep Res 8(Supp 1): 53-59.

217. Obál F Jr, Kapás L, Gardi J, Taishi P, Bodosi B, Krueger JM. (1999) Insulin-like growth factor-1 (IGF-1) induced inhibition of growth hormone secretion is associated with sleep suppression. Brain Res 818: 267-274.

218. Krueger JM, Obál F Jr, Fang J. (1999) Why we sleep. Sleep Med Rev 3: 119-129.

219. Obál F Jr, Krueger JM. (2000) Hormones, cytokines and sleep. In: Coping with the Environment Neural and Endocrine Mechanisms: Handbook of Physiology. McEwen BS (ed); Oxford University Press; Chapter 16, pp 331-349.

KRUEGER, James M.

-39-

220. Krueger JM, Fang J. (2000) Sleep and host defense. In: Principles and Practice of Sleep Medicine; 3

rd edition. Kryger MH, Roth T, Dement W (eds); WB Saunders Co:

Orlando, FL; pp 255-265.

221. Krueger JM. (1998) Neurochemistry of sleep regulation. Le Cahiers du Médecin 13: 14-15.

222. Pabst MJ, Beranova S, Krueger JM. (1999) A review of the effects of muramyl peptides on macrophages, monokines and sleep. Neuroimmunomodulation 6: 261-283.

223. Kushikata T, Fang F, Krueger JM. (1999) Interleukin-10 inhibits spontaneous sleep in rabbits. J Interferon Cytokine Res 19: 1025-1030.

224. Hansen MK, Krueger JM. (1999) Kupffer cell depletion with gadolinium chloride prevents cafeteria diet-induced sleep in rats. Sleep 22: 707-715.

225. Roky R, Kapás L, Taishi P, Fang J, Krueger JM. (1999) Food restriction alters the diurnal distribution of sleep in rats. Physiol Behav 67: 697-703.

226. Gardi J, Obál F Jr, Fang J, Zhang J, Krueger JM. (1999) Diurnal variations and sleep-deprivation-induced changes in rat hypothalamic GHRH and somatostatin contents. Am J Physiol 46: R1339-R1344.

227. Beranek L, Hajdu I, Gardi J, Taishi P, Obál F Jr, Krueger JM. (1999) Central administration of the somatostatin analog octreotide induces captopril-insensitive sleep responses. Am J Physiol 46: R1297-R1304.

228. Krueger JM, Fang J, Obál F Jr. (2000) La solitude nocturne des neurons. La Recherche A3, April; pp 26-27.

229. Krueger JM. (2000) Cytokines and growth factors in sleep regulation. In: HFSP Workshop 8: The Regulation of Sleep; pp 122-131.

230. Krueger JM, Fang J, Majde JA. (2001) Sleep in health and disease. In: Psychoneuroimmunology, 3

rd edition. Ader B, Felton D, Cohen N (eds); Academic

Press; pp 667-685.

231. Hajdu I, Obál F Jr, Gardi J, Laczi F, Krueger JM. (2000) Octreotide-induced drinking, vasopressin and pressure responses: involvement of central angiotensin and acetylcholine. Am J Physiol 279: R271-R277.

232. Kubota T, Kushikata T, Fang J, Krueger JM. (2000) A nuclear factor kappa (NFkB)

inhibitor peptide inhibits spontaneous and interleukin-1-induced sleep. Am J Physiol 279: R404-R413.

233. Kubota T, Fang J, Kushikata T, Krueger JM. (2000) Interleukin 13 and transforming

growth factor-1 inhibit spontaneous sleep in rabbits. Am J Physiol 279: R786-R792.

234. Bodosi B, Obál F Jr, Gardi J, Komlódi J, Krueger JM. (2000) Ether stress induces increases in REM sleep in the rat: possible role of prolactin. Am J Physiol 279: R1590-R1598.

235. Krueger JM, Obál F Jr, Fang J, Kubota T, Taishi P. (2001) The role of cytokines in sleep regulation. Ann NY Acad Sci 933: 211-221.

236. Renegar KB, Crouse D, Floyd RA, Krueger JM. (2000) Progression of influenza viral infection through the respiratory tract: the protective role of short-term sleep-deprivation. Sleep 23: 859-863.

KRUEGER, James M.

-40-

237. Rehman A, Taishi P, Fang J, Majde JA, Krueger JM. (2001) The cloning of a rat peptidoglycan recognition protein (PGRP) and its induction in brain by sleep deprivation. Cytokine 13: 8-17.

238. Kubota T, Fang J, Guan Z, Brown RA, Krueger JM. (2001) Vagotomy attenuates tumor

necrosis factor- induced sleep and EEG delta activity. Am J Physiol 280: R1213-1220.

239. Kushikata T, Kubota T, Fang J, Krueger JM. (2001) Glial cell line-derived neurotrophic factor (GDNF) promotes sleep in rats and rabbits. Am J Physiol 280: R1001-R1006.

240. Obál F Jr, Fang J, Taishi P, Kacsóh B, Gardi J, Krueger JM. (2001) Deficiency of growth hormone-releasing hormone signaling is associated with sleep alterations in the dwarf rat. J Neurosci 21: 2912-2918.

241. Churchill L, Taishi P, Guan Z, Chen L, Fang J, Krueger JM. (2001) Sleep modifies glutamate decarboxylase mRNA within the barrel cortex of rats after a mystacial whisker trim. Sleep 24: 261-266.

242. Brandt J, Churchill L, Guan Z, Fang J, Chen L, Krueger JM. (2001) Sleep deprivation, but not a whisker trim, increases nerve growth factor within barrel cortical neurons. Brain Res 898: 105-112.

243. Obál F Jr, Krueger JM. (2001) The somatotropic axis and sleep. Revue Neurologique 157: 5512-5515.

244. Krueger JM, Obál F Jr. (2002) Function of sleep. In: Sleep Medicine. Lee-Choing T, Carskadon M, Sateia M (eds); Hanley & Belfus, Inc: Philadelphia, PA; pp 23-30.

245. Majde JA, Krueger JM. Neuroimmunology of sleep. (2002) In: Textbook of Biological Psychiatry. D’haenen H, den Boer JA, Westenberg H, Willner P (eds); John Wiley & Sons, Ltd: London, UNITED KINGDOM; Chapter 24-4, pp 1247-1257.

246. Taishi P, Sanchez C, Wang Y, Fang J, Harding JW, Krueger JM. (2001) Conditions that affect sleep alter the expression of molecules associated with synaptic plasticity. Am J Physiol 281: R839-R845.

247. Kubota T, Brown RA, Fang J, Krueger JM. (2001) Interleukin-15 and interleukin-2 enhance non-REM sleep in rabbits. Am J Physiol 281: R1004-R1012.

248. Kubota T, Fang J, Brown RA, Krueger JM. (2001) Interleukin-18 promotes sleep in rabbits and rats. Am J Physiol 281: R828-R838.

249. Kubota T, Majde JA, Brown RA, Krueger JM. (2001) Tumor necrosis factor receptor

fragment attenuates interferon--induced non-REM sleep in rabbits. J Neuroimmunol 119: 192-198.

250. Gardi J, Krueger JM, Speth RC. (2001) Preparation and a simple one-step purification of [His

1-mono-

125I-tyr

10, Nle

27]-hGHRH (1-32)-NH2. J Labeled Compounds Radiopharm

44: 1-6.

251. Kubota T, Fang J, Meltzer LT, Krueger JM. (2001) Pregabalin enhances non-REM sleep. J Pharm Exp Ther 299: 1095-1105.

252. Hajdu I, Obál F Jr, Fang J, Krueger JM, Rollo CD. (2002) Sleep of transgenic mice producing excess rat growth hormone. Am J Physiol 282: R70-R76.

KRUEGER, James M.

-41-

253. Gardi J, Szentirmai É, Hajdu I, Obál F Jr, Krueger JM. (2001) The somatostatin analog, octreotide, inhibits GHRH and stimulates angiotensin release in the rat hypothalamus. Neurosci Lett 315: 37-40.

254. Kubota T, Li N, Z Guan, Brown R, Krueger JM. (2002) Intrapreoptic microinjection of

TNF enhances non-REM sleep in rats. Brain Res 932: 37-44.

255. Krueger JM, Obál F Jr, Harding JW, Wright JW, Churchill L. (2003) Sleep modulation of the expression of plasticity markers. In: Sleep and Brain Plasticity. Maquet P, Stickgold R, Smith C (eds); Oxford University Press: Oxford, UNITED KINGDOM; pp 363-376.

256. Kubota T, De A, Brown RA, Simasko SM, Krueger JM. (2002) Diurnal effects of acute and chronic administration of ethanol on sleep in rats. Alcohol Clin Exp Res 26: 1153-1161.

257. Gardi J, Speth RC, Taishi P, Kacsóh B, Obál F Jr, Krueger JM. (2002) Alterations in GHRH binding in the pituitary of adult dw/dw rats. Peptides 23: 1497-1502.

258. Gardi J, Taishi P, Speth RC, Obál F Jr, Krueger JM. (2002) Sleep loss alters hypothalamic growth hormone-releasing hormone receptors. Neurosci Lett 320: 69-72.

259. Krueger JM, Churchill L. Cytokines in sleep regulation. (2003) In: Cytokine and Mental Health. Krontol A (ed); Kluwer Academic Publishers: New York, NY; pp 147-166.

260. De A, Churchill L, Obál F Jr, Simasko SM, Krueger JM. (2002) GHRH and IL1 increase cytoplasmic Ca

2+ levels in cultured hypothalamic GABAergic neurons. Brain Res 949:

209-212.

261. Obál F Jr, Alt J, Taishi P, Gardi J, Krueger JM. (2003) Sleep in mice with non-functional growth hormone (GH)-releasing hormone (GHRH) receptors. Am J Physiol 284: R131-R139.

262. Krueger JM, JA Majde, Obál F Jr. (2003) Sleep in host defense. Brain Behav Immunity 17: S41-S47.

263. Obál F Jr, Krueger JM. (2003) Biochemical regulation of sleep. Frontiers Biosci 8: 520-550.

264. Krueger JM, Obál F Jr. (2003) Sleep function. Frontiers Biosci 8: 511-519. PMID: 12700033

265. Krueger JM, Majde JA. (2003) Humoral links between sleep and the immune system – Research Issues. Ann NY Acad Sci 992: 9-20.

266. Alt J, Obál F Jr, Traynor TR, Gardi J, Majde JA, Krueger JM. (2003) Sleep responses to influenza viral infection in GHRH-receptor deficient mice. J Appl Physiol 95: 460-468.

267. Obál F Jr, Garcia-Garcia F, Krueger JM. (2005) The role of endogenous sleep promoting substances. In: Sleep Deprivation: Clinical Issues. Kushida CA (ed); Marcel-Dekker, Inc; pp 515-538.

268. Chen L, Majde JA, Krueger JM. (2003) Spontaneous sleep in mice with targeted disruptions of neuronal or inducible nitric oxide synthase genes. Brain Res 973: 214-222.

KRUEGER, James M.

-42-

269. Yoshida H, Kubota T, Krueger JM. (2003) A cyclooxygenase-2 inhibitor attenuates

spontaneous and TNF-induced non-rapid eye movement sleep in rabbits. Am J Physiol 285: R99-R109.

270. De A, Krueger JM, Simasko SM. (2003) Tumor necrosis factor increases cytosolic Ca

++ responses to AMPA and KCl in primary cultures of rat hippocampal neurons.

Brain Res 981: 133-142.

271. Kushikata T, Kubota T, Fang J, Krueger JM. (2003) Neurotrophin 3 and 4 enhance spontaneous sleep in rabbits. Neurosci Lett 346: 161-164.

272. Garcia-Garcia F, Krueger JM. (2003) Intracerebroventricular injection of erythropoietin enhances sleep in the rat. Brain Res Bull 61: 541-546.

273. Cearley C, Churchill L, Krueger JM. (2003) Time of day differences in IL1 and TNF mRNA levels in specific regions of brain. Neurosci Lett 352: 64-66.

274. Hajdu I, Szentirmai É, Obál F Jr, Krueger JM. (2003) Different brain structures mediate drinking and sleep suppression elicited by the somatostatin analog, octreotide, in rats. Brain Res 994: 115-123.

275. Krueger JM, Majde JA. (2005) Host Defense. In: Principles and Practice of Sleep Medicine; 4

th Edition. Kryger M (Editor-in-Chief); Elsevier Science: Philadelphia, PA;

pp 256-265.

276. Peterfi Z, Churchill L, Hajdu I, Obál F Jr, Krueger JM, Parducz A. (2004) Fos-immunoreactivity in the hypothalamus: dependency on the diurnal rhythm, sleep, gender and estrogen. Neuroscience 124: 695-707.

277. Taishi P, De A, Alt J, Gardi J, Obál F Jr, Krueger JM. (2004) Interleukin-1 stimulates GHRH receptor mRNA expression in the rat hypothalamus in vitro and in vivo. J Neuroendocrinol 16: 113-118.

278. Traynor TR, Majde JA, Bohnet SG, Krueger JM. (2004) Intratracheal double-stranded

RNA plus interferon-: a model for analysis of the acute phase response to respiratory viral infections. Life Sci 74: 2563-2576.

279. Churchill L, Krueger JM. (2003) Growth factors in sleep regulation and neural connectivity: implications for sleep function. Rec Res Dev Physiol 1: 819-843.

280. Brandt JA, Churchill L, Rehman A, Ellis G, Mémet S, Israël A, Krueger JM. (2004) Sleep-deprivation increases activation of nuclear factor kappa B in lateral hypothalamic cells. Brain Res 1004: 91-97.

281. Garcia-Garcia F, Yoshida H, Krueger JM. (2004) Interleukin-8 promotes sleep in rabbits and rats. J Sleep Res 13: 55-61.

282. Chen L, Taishi P, Majde JA, Peterfi Z, Obál F Jr, Krueger JM. (2004) The role of nitric

oxide synthases in the sleep response to tumor necrosis factor . Brain Behav Immun 18: 390-398.

283. Wright JW, Alt J, Turner GD, Krueger JM. (2004) Differences in spatial learning comparing transgenic p75 knockout New Zealand Black, C57BL/6 and Swiss Webster mice. Behav Brain Res 153: 453-458.

284. Chen L, Duricka D, Nelson S, Mukherjee S, Bohnet SG, Taishi P, Majde JA, Krueger JM. (2004) Influenza virus-induced sleep responses in mice with targeted disruptions in neuronal or inducible nitric oxide synthases. J Appl Physiol 97: 17-28.

KRUEGER, James M.

-43-

285. Yoshida H, Peterfi Z, Garcia-Garcia F, Kirkpatrick R, Yasuda T, Krueger JM. (2004) State-specific asymmetries EEG in slow wave sleep induced by local application of

TNF. Brain Res 1009: 129-136.

286. Obál F Jr, Krueger JM. (2004) GHRH and sleep. Sleep Med Rev 8: 367-377.

287. Chen L, Taishi P, Duricka D, Krueger JM. (2004) Brainstem prolactin mRNA is enhanced in mice with suppressed neuronal nitric oxide synthase activity. Mol Brain Res 129: 179-184.

288. Nelson SE, Duricka D, Campbell KB, Churchill L, Krueger JM. (2004) Homer 1a and 1bc levels in the rat somatosensory cortex vary with the time of day and sleep loss. Neurosci Lett 367: 105-108.

289. Obál F Jr, Krueger JM. Humoral mechanisms of sleep. (2005) In: The Physiological Nature of Sleep. Parmeggiani PL, Velluti R (eds); Imperial College Press; pp 23-44.

290. Bodosi B, Gardi J, Hajdu I, Szentirmai É, Obál F Jr, Krueger JM. (2004) Rhythms of ghrelin, leptin and sleep in rats: effects of the normal diurnal cycle, restricted feeding, and sleep deprivation. Am J Physiol 287: R1071-R1079.

291. Bohnet S, Traynor TR, Majde JA, Kacsóh B, Krueger JM. (2004) Mice deficient in the interferon type I receptor have reduced REM sleep and altered hypothalamic orexin, prolactin and 2’,5’-oligoadenylate synthetase expression. Brain Res 1027: 117-125.

292. Krueger JM, Majde JA. (2006) Sleep and the immune response. In: A Comprehensive Handbook of Sleep Medicine. Lee-Chiong TL (ed); John Wiley & Sons, Inc: Hoboken, NJ; pp 767-772.

293. Yasuda T, Yoshida H, Garcia-Garcia F, Kay D, Krueger JM. (2005) Interleukin-1 has a role in cerebral cortical state dependent electroencephalographic slow-wave activity. Sleep 28: 177-184.

294. Garcia-Garcia F, Ponce S, Brown R, Cussen V, Krueger JM. (2005) Sleep disturbances in the rotenone-animal model of Parkinson Disease. Brain Res 1042: 160-168.

295. Tang C, Sula MJ, Bohnet S, Rehman A, Taishi P, Krueger JM. (2005) Interleukin-1 induces CREB-binding protein (CBP) mRNA in brain and the sequencing of rat CBP. Mol Brain Res 137: 213-222.

296. Krueger JM. (2005) Mechanisms underlying the central effects of cytokines. In: Neuroimmune Mechanisms and Chronic Fatigue Syndrome. NIH Publication No 04-5497, pp 63-70.

297. Alt J, Bohnet S, Taishi P, Duricka D, Obál F Jr, Traynor T, Majde JA, Krueger JM. (2007) Influenza virus-induced glucocorticoid and hypothalamic cytokine mRNA responses in dwarf Lit/Lit mice. Brain Behav Immun 21: 60-67.

298. Churchill L, Yasuda K, Yasuda T, Blindheim K, Falter M, Garcia-Garcia F, Krueger JM.

(2005) Unilateral cortical application of tumor necrosis factor induces asymmetry in

Fos- and interleukin-1 immunoreactive cells within the corticothalamic projection. Brain Res 1055: 15-24.

299. De A, Krueger JM, Simasko SM. (2005) Expression and release of glutamate-induced

TNF in cultured hypothalamic cells. Brain Res 1053: 54-61.

KRUEGER, James M.

-44-

300. Yasuda T, Yasuda K, Brown R, Krueger JM. (2005) State-dependent effects of the light/dark cycle on the somatosensory and the visual cortex EEG in rats. Am J Physiol 289: R1083-R1089.

301. Traynor T, Majde JA, Bohnet S, Krueger JM. (2006) Sleep and body temperature responses in an acute viral infection model are altered in interferon type I receptor-deficient mice. Brain Behav Immunity 20: 290-299.

302. Majde JA, Krueger JM. (2005) Links between the innate immune system and sleep. J Allergy Clin Immunol 116: 1188-1198.

303. Kushikata T, Fang J, Krueger JM. (2006) Platelet activating factor and its metabolite promote sleep in rabbits. Neurosci Lett 394: 233-238.

304. Obál F Jr, Garcia-Garcia F, Kacsóh B, Taishi P, Bohnet S, Horseman ND, Krueger JM. (2005) REM sleep is reduced in prolactin deficient mice. J Neurosci 25: 10282-10289.

305. Alfoldi P, Kapás L, Szentirmai É, Taishi P, Gardi J, Peterfi Z, Kacsóh B, Krueger JM. (2006) The somatotropic axis in sleep and thermo regulation. J Thermal Biol 31: 30-39.

306. Krueger JM, Majde JA, Rector DM. Cytokines in immune function and sleep regulation. Handbook of Clinical Neurology. Vol 98 (3

rd series) Sleep Disorders, Part 1. P.

Montagna and S Chokroverty, Editors, Elsevier B.V. Chapter 15, pp 229-240 (2011)

307. Szentirmai É, Hajdu I, Obál F Jr, Krueger JM. (2006) Ghrelin-induced sleep responses in ad libitum fed and food restricted rats. Brain Res 1088: 131-140.

308. Szentirmai É, Krueger JM. (2006) Central administration of neuropeptides Y induces wakefulness in rats. Am J Physiol 291: R473-R480.

309. Davis CJ, Meighan PC, Taishi P, Krueger JM, Harding JW, Wright JW. (2006) REM sleep deprivation attenuates actin-binding protein cortactin: a link between sleep and hippocampal plasticity. Neurosci Lett 400: 191-196.

310. Peterfi Z, Obál F Jr, Taishi P, Gardi J, Kacsóh B, Unterman T, Krueger JM. (2006) Sleep in spontaneous dwarf rats. Brain Res 1108: 133-146.

311. Szentirmai É, Krueger JM. (2006) Obestatin alters sleep in rats. Neurosci Lett 404: 222-226.

312. Krueger JM, Rector DM, Churchill L. Cytokines and Sleep. (2008) In: Neuroimmune Biology; Vol 6: “Cytokines and the Brain”. Phelps C, Kornova E (eds); Elsevier BV: Oxford. pp 213-240.

313. Churchill L, Taishi P, Wang M, Brandt J, Cearley C, Krueger JM. (2006) Brain distribution of cytokine mRNA induced by systemic administration of interleukin-1 or tumor necrosis factor α. Brain Res 1120: 64-73.

314. Traynor T, Majde JA, Bohnet S, Krueger JM. (2007) Interferon type I receptor-deficient mice have altered disease symptoms in response to influenza virus. Brain Behav Immunity 21: 311-322.

315. Krueger JM, Churchill L, Rector DM. (2009) Sleep and sleep states: cytokines and neuromodulation. Encyclopedia of Neurosci. 8:905-911.

316. Szentirmai É, Kapás L, Krueger JM. (2007) Ghrelin microinjection into forebrain sites induces wakefulness and feeding in rats. Am J Physiol 292: R575-R585.

KRUEGER, James M.

-45-

317. Yasuda K, Churchill L, Yasuda T, Blindheim K, Falter M, Krueger JM. (2007) Unilateral

cortical application of interleukin-1 (IL1) induces asymmetry in Fos- and IL1-immunoreactivity: Implications for sleep regulation. Brain Res 1131: 44-59.

318. Cambras T, Weller JR, Angles-Pujoras M, Lee M, Christopher H, Oiez-Noguera A, Krueger JM, de la Iglesia H. (2007) Desynchronization of core body temperature and sleep stages is associated with uncoupling of oscillators within the master circadian clock. Proc Natl Acad Sci. 104: 7634-7639.

319. Krueger JM, Rector DM, Churchill L. Sleep and cytokines. (2007) Sleep Med Clinics. 2: 161-169.

320. Majde JA, Bohnet SG, Ellis GA, Churchill L, Leyva-Grado V, Wu M, Szentirmai É, Rehman A, Krueger JM. (2007) Detection of a mouse-adapted human influenza virus in the olfactory bulb of mice within hours after intranasal infection. J NeuroVirol 13: 399-409.

321. Szentirmai É, Kapás L, Sun Y, Smith RG, Krueger JM. (2007) Spontaneous sleep and homeostatic sleep regulation in ghrelin knockout mice. Am J Physiol 293: R510-R517.

322. Manoranjan VS, Rajapakse I, Krueger JM. (2006) Oscillation in a neuronal assembly – A phenomenological model. Int J Computa Appl Math 1:57-64.

323. Taishi P, Churchill L, Wang M, Kay D, Davis CJ, Guan X, De A, Yasuda T, Liao F,

Krueger JM. (2007) TNF siRNA reduces brain TNF and EEG delta wave activity in rats. Brain Res 1156: 125-132.

324. Davis CJ, Bohnet SG, Meyerson JM, Krueger JM. (2007) Sleep loss changes microRNA levels in the brain: A possible mechanism for state-dependent translational regulation. Neurosci Lett 422: 68-73.

325. Szentirmai É, Yasuda T, Taishi P, Wang W, Churchill L, Bohnet S, Magrath P, Kacsóh B, Jimenez L, Krueger JM. (2007) Growth hormone releasing hormone: Cerebral cortical sleep-related EEG actions and expression. Am J Physiol 293: R922-R930.

326. Krueger JM. What exactly is it that sleeps? The evolution, regulation and organization of an emergent network property. (2010) In: The Evolution of Sleep: Phylogenetic and Functional Perspectives. P McNamara, R Barton, C Nunn (eds); Cambridge University Press. Pp 86-106.

327. Krueger JM, Leyva-Grado V, Bohnet S. (2009) Cytokines, host defense and sleep. Atlas Clin Sleep Med. Chapter 3.5, Elsevier: Philadelphia, PA. pp 34-36.

328. Von Dongen HPA, Rector DM, Belenky G, Krueger JM. (2009) Sleep a localized phenomenon of the brain. Atlas Clin Sleep Med. Chapter 3.3, Elsevier: Philadelphia, PA. pp 27-29.

329. Szentirmai É, Kapás L, Krueger JM. (2009) Interactive regulation of sleep and feeding. Atlas Clin Sleep Med. Chapter 3.9, Elsevier: Philadelphia, PA. pp 53-56.

330. Churchill L, Rector DM, Yasuda K, Fix C, Rojas MJ, Yasuda T, Hall SJ, Guan X, Krueger

JM. (2008) Tumor necrosis factor : activity dependent expression and promotion of cortical column sleep in rats. Neuroscience 156:71-80. PMCID: PMC2654198.

331. Roy S, Krueger JM, Rector DM, Wan Y. (2008) Network models for activity-dependent sleep regulation. J Theor Biol. 253:462-468. PMCID: PMC2592512

332. Krueger JM. The role of cytokines in sleep regulation. (2008) Current Pharm Design 14:3408-3416. PMCID: PMC2692603

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333. Kapás L, Bohnet S, Traynor T, Majde JA, Szentirmai É, Magrath P, Taishi P, Krueger JM. (2008) Spontaneous and influenza virus-induced sleep are altered in TNFα double receptor deficient mice. J Appl Physiol 105:1187-1198. PMCID: PMC2576045

334. Taishi P, Churchill L, De A, Obal Jr F, Krueger JM. (2008) Cytokine mRNA induction by interleukin-1 beta or tumor necrosis factor alpha in vitro and in vivo. Brain Res. 1226:89-98. PMCID: PMC2642478

335. Krueger JM, Rector DM, Roy S, Van Dongen HPA, Belenky G, Panksepp J. (2008) Sleep as a fundamental property of neuronal assemblies. Nature Reviews Neuroscience 9:910-919. PMCID: PMC2586424.

336. Krueger JM, Majde JA. (2009) Immunity and sleep. In: Sleep Medicine Essentials. Ed. Teofilo L. Lee-Chiong. John Wiley & Sons. Inc. Pp 223-226.

337. Krueger JM (2008) Humoral regulation of sleep; implications for sleep as an emergent use-dependent local process. Revista Medica de la Universidad Veracruzana Supp 2 vol 8:46-52. no PMCID.

338. Peterfi Z, Makara GB, Obal Jr F, Krueger JM (2009) The anterolateral projections of the medial basal hypothalamus affect sleep. Am. J. Physiol. 296:R1228-R1238. PMCID: PMC2698612.

339. Rector DM, Schei JL, Van Dongen HPA, Belenky G, Krueger JM. (2009) Physiological markers of localized sleep. Europ. J. Neurosci. 29:1771-1778. PMCID: PMC2688439

340. Krueger JM, Szentirmai E, Kapas L. (2009) The biochemistry of sleep function. SRS Basics of Sleep Guide; Sleep Research Society CJ Amlaner, PM Fuller editors, pp 69-74.

341. Leyva-Grado V, Churchill L, Wu M, Williams, TJ, Taishi P, Majde JA, Krueger JM. (2009) Influenza virus- and cytokine-immunoreactive cells in the murine olfactory pathway and hypothalamus before and after illness onset. J. Neuroimmunol. 211:73-83. PMCID: PMC2696569.

342. May U, Schiffelholz T, Baier PC, Krueger JM, Rose-John S, Scheller J. (2009) IL-6trans-signalling increases rapid eye-movement sleep in rats. European. J. Pharmacology 613:141-145. PMID: 19383497

343. Szentirmai É, Kapás L, Sun Y, Smith RG, Krueger JM. (2009) The preproghrelin gene is required for normal integration of thermoregulation and sleep in mice. Proc. Natl. Acad. Sci. USA 106:14069-14074. PMCID: PMC2729021

344. Leyva-Grado V, Churchill L, Harding J, Krueger JM. (2010) The olfactory nerve has a role in the body temperature and brain cytokine responses to influenza virus. Brain Beh. Immun. 24:281-288. PMCID: PMC2818451

345. Van Dongen HPA, Belenky G, Krueger JM. Investigating the temporal dynamics and underlying mechanisms of cognitive fatigue. (2011). In: Cognitive Fatigue. Am. Psychol. Assoc. P. Ackerman (Ed.) pp 127-148, Washington DC.

346. Szentirmai E, Kapas L, Krueger JM. Sleep and Hormones. (2010) Encyclopedia of Animal Behavior. Breed, M.D. & Moore, J. eds. pp 203-206, Oxford: Academic Press.

347. Majde JA, Kapas L, Bohnet SG, De A, Krueger JM. (2010) Attenuation of the influenza virus sickness behavior in mice deficient in Toll-like receptor 3. Brain Beh. Immun. 24:306-315. PMCID: 2818367

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348. Szentirmai E, Kapas, L, Sun Y, Smith RG, Krueger JM. (2010) Restricted feeding-induced sleep, activity and body temperature changes in normal and preproghrelin deficient mice. Am. J. Physiol. 298:R467-R477. PMCID: PMC2828180

349. Liao F, Taishi P, Churchill L, Urza JM, Krueger JM. (2010) Localized suppression of cortical growth hormone releasing hormone receptors state-specifically attenuates EEG delta waves. J. Neuroscience. 30:4151-4159. PMCID: PMC2846621

350. Hallett H, Churchill L, Taishi P, De A, Krueger JM. (2010) Whisker stimulation increases expression of nerve growth factor and interleukin-1 beta immunoreactivity in the rat somatosensory cortex. Brain Res.1333:48-56. PMCID: PMC2879054

351. Hight K, Hallett H, Churchill L, De A, Boucher A, Krueger JM. (2010) Time of day differences in the number of cytokine-, neurotrophin- and NeuN-immunoreactive cells in the rat somatosensory or visual cortex. Brain Res.1337:32-40. PMCID: PMC2892412

352. Zielinski MR, Krueger JM. Sleep and innate immunity. Encyclopedia of Bioscience, Front. Biosciences. (Schol. Ed.) 3:632-642, 2011. M. A. Miller (editor) PMID: 21196401

353. Sengupta P, Roy S, Krueger JM. (2011) The ATP-cytokine-adenosine hypothesis; How the brain translates past activity into sleep. Sleep and Biological Rhythms 9:29-33. PMCID: PMCID: PMC2980381

354. Zielinski, MR, Krueger JM. (2012) Inflammation and Sleep. Therapy in Sleep Medicine, Barkoukis, TJ, Matheson JK, Ferber R and Doghramji K (eds). Elsevier. Pp 607-616.

355. Krueger JM, Taishi P, De A, Davis C, Winters BD, Clinton J, Szentirmai E, Zielinski MR. (2010) ATP and the purine type 2 X7 receptor affect sleep. J Appl Physiol. 109:1318-1327. PMCID: PMC2980381

356. Krueger JM and Majde JA. Sleep and Host Defense. In Principles and Practice of Sleep Medicine, Fifth edition. Kryger MH, Roth T, and Dement WC eds. Elsevier, 2011, pp 281-290. No PMCID.

357. Van Dongen HPA, Belenky G, Krueger JM. (2011) A local, bottom-up perspective on sleep deprivation and neurobehavioral performance. Current Topics in Medicinal Chemistry 11:2414-2422. PMCID: PMC3243827.

358. Krueger JM, Wisor JP. (2011) Local use-dependent sleep; an introduction. Current Topics in Medicinal Chemistry 11:2390-2391. PMID 22181666; PMCID: not yet assigned.

359. Krueger JM, Tononi G. (2011) Local use-dependent sleep; synthesis of the new paradigm. Current Topics in Medicinal Chemistry 11:2490-2492. PMID 21906015; PMCID: 3248786.

360. Gardi J, Nelson OL, Robbins CT, Szentirmai E, Kapas L, Krueger JM. (2011) Energy homeostasis regulatory peptides in hibernating grizzly bears. Gen. and Comp. Endocrinology 172:181-183. PMCID: PMC3263427.

361. Krueger JM, Clinton JM, Winters BD, Zielinski MR, Taishi P, Jewett KA, Davis CJ. (2011) Involvement of cytokines in slow wave sleep. Prog. in Brain Res. 193C:39-47. PMID: 21854954; PMCID: not yet assigned.

362. Cearley C, Blindheim K, Sorg B, Krueger JM, Churchill L. (2011) Acute cocaine increases interleukin-1 beta and protein levels in the cortex and nucleus accumbens. Neurochemical Res. 36:686-692. PMID: 21399909; PMCID: not yet assigned.

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363. Davis, CJ, Clinton JM, Taishi P, Bohnet SG, Honn, KA, Krueger, JM. (2011) MicroRNA 132 alters sleep and varies with time in brain. J Appl. Physiol. 111:665-672. PMCID: PMC3174793.

364. Hodgson NR, Bohnet SG, Majde JA, Krueger JM. Influenza virus pathophysiology and brain invasion in mice with functional and dysfunctional Mx1 genes. (2012) Brain, Behav. Immunity 26:83-89. PMCID: PMC3221813.

365. Davis CJ, Clinton JM, Jewett K, Zielinski MR, Krueger, JM (2011) EEG delta wave power: An independent sleep phenotype or epiphenomena? J. Clin. Sleep Med. 7:S16-S18. PMCID: PMC3190419.

366. Clinton JM, Davis CJ, Zielinski MR, Jewett K, Krueger JM (2011). Biochemical regulation of sleep and sleep biomarkers. J. Clin. Sleep Med. 7:S38-S42. PMCID: PMC3190410.

367. Winters BD, Huang Y, Dong Y, Krueger JM. (2011) Sleep loss alters synaptic and intrinsic neuronal properties in mouse prefrontal cortex. Brain Res 1420:1-7. PMCID: 21962531, PMC3205322.

368. Taishi P, Davis CJ, Bayomy O, Zielinski MR, Liao F, Clinton JM, Smith DE, Krueger JM. Brain –specific interleukin-1 receptor accessory protein in sleep regulation. (2012) J. Appl. Physiol. 112:1015-1022. PMID: 22174404; PMCID: in process.

369. Krueger JM. Translation of brain activity into sleep. (2011) Hirosaki Med. J. 62:S1-S16. PMCID: not assigned.

370. Oonk M, Davis CJ, Krueger JM, Wisor JP, Van Dongen HPA (2011). Investigating the two-trial Y-maze as a performance assay for short-duration sleep deprivation studies in c57BL/6 mice. Sleep-Wake Research in the Netherlands 22:72-75. PMCID: not yet assigned.

371. Zielinski M, Taishi P, Clinton JM, Krueger JM. (2012) 5’-ectonucleotidase knockout mice lack non-REM sleep responses to sleep deprivation. Europ. J. Neurosci. 35:1789-1798. PMCID: not yet assigned. PMID: 22540145.

372. Jewett KA, Krueger JM. (2012) Humoral sleep regulation; interleukin-1 and tumor necrosis factor. Vitam Horm. 89:241-257. PMID:22640617

373. Davis CJ and Krueger JM (2012) Sleep and Cytokines. Sleep Medicine Clinics; Biology of Sleep 7:517-527.

374. Winters BD, Kruger JM, Huang X, Gallaher ZR, Ishikawa M, Czaja, K, Krueger JM, Huang YH, Schluter OM, Dong Y. (2012) CB1-expressing neurons in the nucleus accumbens. Proc. Natl. Acad. Sci. 109:E2717-E2725. PMID: 23012412.

375. Davis, CJ, Clinton JM, Krueger JM. (2012) MicroRNAs 138, let7b and 125a inhibitors differentially alter sleep and EEG delta wave activity in rats. J. Appl. Physiol. 113:1756-1762. PMID: 23104698

376. Clinton JM, Davis CJ, Krueger JM. Cytokines, host defense and sleep. (2012) In: Kryger HM. Atlas of Clinical Sleep Medicine. Philadelphia, PA: Saunders, pp. 457-460.

377. Zielinski MR, Dunbrasky DL, Taishi P, Souza G, Krueger JM. (2013) Vagotomy attenuates brain cytokines and sleep induced by peripherally administered tumor necrosis factor alpha and lipopolysaccharide in mice. Sleep 36:1227-1238.

378. Ingiosi AM, Opp MR, Krueger JM (2013) Sleep and immune function: glial contributions and consequences of aging. Current Opinion in Neurobiology 23:1-6.

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379. Krueger JM, Huang Y, Rector DM, Buysee, DJ. (2013) Sleep: A synchrony of cell activity-driven small network states. European J. Neuroscience 38:2199-2209.

380. Zielinski MR, Souza G, Taishi P, Bohnet SG, Krueger JM. (2013) Olfactory bulb and hypothalamic acute phase responses to influenza virus: Effects of immunization. NeuroImmunoModulation 20:323-333.

381. Szentirmai E, Kapas L, Krueger JM. (2013) Endogenous Sleep-Promoting Substances Encyclopedia of Sleep vol 1: pp 597-601.

382. Szentirmai E, Krueger JM Sickness behavior after lipopolysaccharide treatment in ghrelin deficient mice. Brain Behav. Immunity (In press).

Manuscripts Submitted:

382. Corrigan P, Roy S, Sengupta P, Krueger JM. Network synchronization processes subject to stochastic stimulation: Foundational analysis and application in characterizing cortical sleep regulation.

383. Rosen G, Harris AK, Liu M, Krueger JM, Messinger YH. The effects of dexamethasone on sleep in young children with acute lymphoblastic leukemia.

Book/Conference Reviews:

1. Neuroimmunology of fever. (1993) Reviewed in: Immunology Today 14: 571-572.

2. The 9th Takeda Science Foundation Symposium. (1997) Reported in: World Fed Sleep

Res Soc Newslett 5: 33.

Newsletters:

1. Krueger JM. (1996) What is the minimal component of the brain that is capable of sleep? WFSRS Newslett Vol 5: 1.

2. Krueger JM. (1999) Does the particular behavior, network, cell or chemical that might be the focus of our sleep experiments have anything to do with sleep? WFSRS Newslett Vol 6: 2.

3. Krueger JM, Obál F Jr. (1999) Is state imposed upon the brain by sleep regulatory neuronal networks (i.e., “top-down” regulation), or is the brain state a statistical property of a population of cells or neuronal groups (i.e., “bottom-up” regulation). WFSRS Newslett Vol 7: 1.

4. Krueger JM, Obál F Jr. (2000) Where in the brain should we look when looking for the function of sleep? WFSRS Newslett Vol 8: 1.

5. Krueger JM. (2000) Sleep and the immune system. Nightwalkers: the newsletter of the Restless Legs Syndrome Foundation May: pp 3-4.

6. Krueger JM. (2000) Tripping on the edge of consciousness. VCAPP RECAP September.

Non-Scientific Publications:

KRUEGER, James M.

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1. Krueger JM. (1995) Progress and plans: a continuation of senate success. In: The Record; September 18; p 5.

2. Krueger JM. (1995) Financial concerns, the planning committee and process. The Record; October 18; p 5.

3. Krueger JM. (1995) Secrecy vs. ignorance: who's responsible? The Record; November 20; p 4.

4. Krueger JM. (1995) Political action: a necessity for science education. The Record; December 15; p 2.

5. Krueger JM. (1996) Faculty, public image and the press. The Record; January 18; p 3.

6. Krueger JM. (1996) Academic politics: the good side. The Record; February 2; p 5.

7. Krueger JM. (1996) Tenure, compensation and career pathways (AAMC Meeting). The Record; March 21; p 4.

8. Krueger JM. (1996) Financial realities. The Record; April 3; p 4.

9. Krueger JM. (1998) The SRS - where do we go from here? Sleep Res Bull; 4: 6-7.

10. Krueger JM. (1998) Obituary for Manfred Leslie Karnovsky. Int Soc Neurochem News; No 1, June; pp 59-60.

11. Krueger JM. (2004) Obituary for Ferenc Obál, Jr. ESRS Newslett; September, pp 11-13.

Abstracts:

1. Krueger JM, Botelho S. (1972) Sialic acid content of lacrimal gland fluid and conjuctival fluid. Fed Proc 31: 328.

2. Krueger JM. (1977) Purification of sleep-promoting Factor S. International Union of Physiology Scientists, Proceedings XIII: 413.

3. Krueger JM, Bacsik J, Garcia-Arraras J. (1979) Extraction of sleep-promoting material (SPU) from human urine. Fed Proc 38: 1130.

4. Pappenheimer JR, Krueger JM. (1980) Properties of sleep-promoting Factor S derived from human urine. International Union of Physiology Scientists, Proceedings XIV: 213.

5. Krueger JM, Liu P. (1981) Evidence for two forms of Factor S in human urine. Fed Proc 40: 274.

6. Krueger JM. (1982) Effects on slow wave sleep of Factor S analogs. Fed Proc 41: 1508.

7. Krueger JM, Dinarello C, Chedid L. (1983) Promotion of slow wave sleep by a purified interleukin-1 preparation. Fed Proc 42: 356.

8. Krueger JM, Walter J, Karnovsky M, Lefrancier P, Chedid L, Lederer E. (1983) Muramyl peptides: structural variation and somnogenic activity. Sleep Res 1283.

9. Moldofsky H, Krueger JM, Walter J, Lue FA, Quance G, Orepoulos DG. (1984) Sleep-promoting material extracted from peritoneal dialysates of patients with end-stage renal disease and insomnia. Sleep Res 13: 43.

10. Krueger JM, Walter J. (1984) Persistence of sleep-related thermoregulation during fever and hypothermia. Soc Neurosci Abstr 10: 505.

KRUEGER, James M.

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11. Walter J, Krueger JM, Meyers P, Dinarello C. (1984) Interleukin-1 induced slow-wave sleep and fever: separation of responses. Soc Neurosci Abstr 10: 147.

12. Krueger JM. (1984) Somnogenic muramyl peptides and interleukin-1. 23rd International

Congress of Psychologists, Proceedings p 36.

13. Krueger JM. (1984) Muramyl peptides and related somnogenic factors. Sleep substances and sleep. 8

th Taniguchi Foundation International Symposium, Proceedings p 4.

14. Krueger JM. (1984) Muramyl peptides and interleukin-1 as promoters of slow-wave sleep. 8

th Taniguchi Foundation International Symposium, Proceedings pp 38-40.

15. Krueger JM, Walter J, Davenne D, Shoham S, Dinarello CA. (1985) Interferon alpha-2 enhances slow-wave sleep in rabbits. Soc Neurosci Abstr 11: 1283.

16. Ahmed MS, Krueger JM, Blatteis CM. (1985) Muramyl dipeptide does not affect opioid binding in guinea pig brain. Soc Neurosci Abstr 11: 1071.

17. Krueger JM. (1985) Somnogenic muramyl peptides. 2nd

International Workshop “Biological Properties of Peptidoglycan”, Proceedings p 46.

18. Krueger JM. (1985) Induction of slow-wave sleep by interleukin-1. J Leukocyte Biol 7: 720.

19. Krueger JM. (1985) Homologies between sleep factors and hibernation triggers. Living in the Cold Abstr p 76.

20. Karaszewski JW, Krueger JM. (1986) Quantitation of muramic acid and dia-minopimelic acid by high-performance liquid chromatography. Fed Proc 45: 1066.

21. Krueger JM. (1986) Enhancement of slow-wave sleep by endotoxin and Lipid A. J Immunol Immunopharmacol V(3 Suppl): 228.

22. Krueger JM. (1986) Immune modulators as sleep promoters. 2nd

International NIM Workshop, Abstract p 70.

23. Karaszewski JW, Krueger JM. (1986) Muramyl peptides as mammalian physiologic modulators. 2

nd International NIM Workshop, Abstract p 55.

24. Krueger JM, Davenne D, Shoham S. (1986) Enhancement of slow-wave sleep by monophosphoryl Lipid A. Sleep Res 15: 22.

25. Shoham S, Davenne D, Krueger JM. (1986) Tumor necrosis factor enhances slow-wave sleep in rabbits. 8

th European Congress of Sleep Research, Abstract p 328.

26. Davenne D, Krueger JM. (1986) Enhancement of quiet sleep in neonates by muramyl dipeptide. 8

th European Congress of Sleep Research, Abstract p 75.

27. Shoham S, Davenne D, Krueger JM. (1986) Interaction of muramyl dipeptide and amphetamine: Effects on sleep and brain temperature of rabbits. Soc Neurosci Abstr 12: 156.

28. Endsley J, Ahokas RA, Majde JA, Blatteis CM, Krueger JM. (1987) Enhancement of slow-wave sleep by polyriboinosinic:polyribocytidylic acid. Fed Proc 46: 1128.

29. Cady AB, Johannsen L, Riveau G, Chedid L, Dinarello CA, Krueger JM. (1987) Interleukin-1-induced febrile but not slow-wave sleep responses are inhibited by the muramyl peptide murametide. Sleep Res 16: 79.

KRUEGER, James M.

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30. Johannsen L, Cady AB, Krueger JM. (1987) Muramyl peptide structure-somnogenic activity relationships. Sleep Res 16: 96.

31. Shoham S, Blatteis CM, Ahokas RA, Krueger JM. (1987) Effects of bilateral preoptic anterior hypothalamic damage on muramyl dipeptide-induced sleep, fever and hypercupremia. Sleep Res 16: 145.

32. Johannsen L, Karaszewski JM, Krueger JM. (1987) Quantitation of muramic acid and diaminopimelic acid in human urine. International Symposium “Immunomodule Non-Specific Host Mechanisms Against Microbial Infections”, Abstract p 44.

33. Toth LA, Krueger JM. (1987) Effects of Staphylococcus aureus infection on slow-wave sleep in rabbits. Soc Neurosci Abstr 13: 261.

34. Johannsen L, Wecke J, Krueger JM. (1987) Macrophage processing of bacteria: CNS-active substances are produced. Soc Neurosci Abstr 13: 261.

35. Obál F Jr, Johannsen L, Cady AB, Krueger JM. (1987) Growth hormone-releasing factor increases both non-REM sleep and REM sleep in rabbits. Soc Neurosci Abstr 13: 261.

36. Krueger JM, Dinarello CA, Shoham S, Cady AB. (1987) Tumor necrosis factor and interleukin-1 enhance slow-wave sleep. J Leukocyte Biol 42: 561.

37. Opp MR, Obál F Jr, Cady AB, Krueger JM. (1988) Effects of alpha-melanocyte-stimulating hormone on sleep and brain temperature and interactions with interleukin-1. Sleep Res 17: 70.

38. Opp MR, Obál F Jr, Krueger JM. (1988) Alpha-MSH inhibits normal and interleukin-1-induced excess sleep in rabbits. 9

th European Congress of Sleep Research, Abstract

p 248.

39. Krueger JM, Johannsen L. (1988) Muramyl peptides and sleep. Neurochem Int 13(Suppl 1): 64.

40. Toth LA, Krueger JM. (1988) Hematological effects of bacterial infections in rabbits. 39th

Annual Meeting of the American Association of Laboratory Animal Scientists, Abstract.

41. Toth LA, Krueger JM. (1988) Infectious challenge alters sleep in rabbits. Soc Neurosci Abstr 14: 1308.

42. Obál F Jr, Opp MR, Cady A, Johannsen L, Alfoldi P, Krueger JM. (1988) Possible links between neuroendocrine process and sleep regulation. 9

th European Congress Sleep

Research, Abstract p 173.

43. Cady AB, Brown RK, Jones MW, Majde JA, Krueger JM. (1989) RNA from influenza-infected lungs increases slow-wave and body temperature while decreasing REM sleep. FASEB J 3: A678.

44. Opp MR, Obál F Jr, Krueger JM. (1989) Corticotropin-releasing factor (CRF) attenuates interleukin-1 (IL-1)-induced non-REM sleep and fever in rabbits. FASEB J 3: A678.

45. Toth LA, Krueger JM. (1989) Somnogenic effects of experimental pasteurellosis in rabbits. Sleep Res 18: 361.

46. Opp MR, Obál F Jr, Krueger JM. (1989) Interleukin-1 and corticotropin-releasing factor: effects on sleep and fever in rabbits. Sleep Res 18: 96.

KRUEGER, James M.

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47. Johannsen L, Toth LA, Krueger JM. (1989) Intravenous injection of bacterial cell walls alters sleep in rabbits. 89

th American Society of Microbiology, Abstract p 33.

48. Toth LA, Krueger JM. (1989) Cortisone and immunization alter the somnogenic effects of infectious challenge in rabbits. Soc Neurosci Abstr 15: 241.

49. Krueger JM, Obál F Jr, Opp MR, Cady AB, Johannsen L. (1989) REM sleep is increased by prolactin, VIP, or PHM treatments in rabbits. Soc Neurosci Abstr 15: 760.

50. Opp MR, Obál F Jr, Krueger JM. (1989) IL6: A pyrogenic cytokine that is not somnogenic. Cytokine 1: 131.

51. Majde JA, Cady AB, Brown R, Jones MW, Krueger JM. (1989) RNase-resistant RNA from influenza-infected lungs alters body temperature and sleep. Cytokine 1: 112.

52. Kapás L, Opp MR, Johannsen L, Krueger JM. (1990) Divergent effects of central and peripheral injections of cholecystokinin (CCK) on sleep-wake activity in rabbits. Sleep Res 19: 18.

53. Opp MR, Obál F Jr, Kapás L, Johannsen L, Krueger JM. (1990) Temporal and dose-related responsiveness of rats to interleukin-1. Sleep Res 19: 101.

54. Krueger JM. (1990) Immune regulation, hormones and sleep. European Sleep Research Society, Abstract p 47.

55. Kapás L, Obál F Jr, Farkas I, Payne LC, Sary G, Rubicsek G, Krueger JM. (1990) Hypnogenic and anorectic effects of CCK persist in vagotomized and in diabetic rats. European Sleep Research Society, Abstract p 93.

56. Opp MR, Obál F Jr, Krueger JM. (1990) Monosodium glutamate treatment of neonates alters responsiveness of rats to interleukin-1. European Sleep Research Society, Abstract p 92.

57. Toth LA, Krueger JM. (1990) Modulation of the somnogenic effects of microbial challenge in rabbits by cortisone administration. European Sleep Research Society, Abstract p 330.

58. Majde JA, Brown R, Jones MW, Dieffenbach CW, Maitra N, Krueger JM, Cady AB, Smitka CW, Maassab HF. (1990) Viral-associated double-stranded RNA from influenza-infected lungs induces fever and altered sleep in rabbits. American Society for Virology, Abstract.

59. Opp MR, Krueger JM. (1990) Human interleukin-1 receptor antagonist (IL1ra) blocks IL1-induced fever and non-rapid eye-movement sleep (NREMS) in rabbits. Soc Neurosci Abstr 16: 603.

60. Hong L, Postlethwaite AP, Johannsen L, Krueger JM. (1990) Muramyl dipeptide (MDP)-induced production of tumor necrosis factor (TNF) by human glioblastoma cells expressing HLADR. Soc Neurosci Abstr 16: 1199.

61. Toth LA, Krueger JM. (1990) Somnogenic impact of trypanosomiasis in rabbits. Soc Neurosci Abstr 16: 1199.

62. Payne LC, Obál F Jr, Kapás L, Krueger JM. (1990) Somnogenic doses of GHRH and IL1 induce GH but not PRL release in rats. Soc Neurosci Abstr 16: 868.

63. Krueger JM. (1990) Sleep and cytokines. 3rd International Conference “TNF Related

Cytokines”, Abstract p 49.

KRUEGER, James M.

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64. Opp MR, Krueger JM. (1990) Interleukin-1-induced non-rapid-eye movement sleep (NREMS) and fever in rabbits are blocked by a human recombinant IL-1 receptor antagonist (IL1-lra). 3

rd International Conference “TNF Related Cytokines”, Abstract p

178.

65. Krueger JM. (1990) Microbial products and cytokines in sleep regulation. 7th

International Symposium “Neuronal Control Bodily Function”, Abstract.

66. Opp MR, Krueger JM. Effects of an interleukin-1 receptor antagonist on recovery sleep of rabbits after total sleep deprivation. Sleep Res 20: 416, 1991.

67. Kapás L, Payne LC, Obál F Jr, Opp MR, Johannsen L, Krueger JM. (1991) Sleep and insulin: the effects of interleukin-1 in diabetic rats. Sleep Res 20: 95.

68. Kimura-Takeuchi M, Majde JA, Toth LA, Krueger JM. (1991) Tolerance to virally-induced changes in sleep of rabbits. Sleep Res 20: 268.

69. Kapás L, Cady AB, Opp MR, Postlethwaite AE, Seyer JM, Krueger JM. (1991)

Somnogenic and pyrogenic activity of TNF, TNF and fragments of TNF. International Society of Immunopharmacologists, Abstract 29.

70. Opp MR, Postlethwaite AE, Seyer JM, Krueger JM. (1991) Biological activities of an

interleukin-1 fragment. International Society of Immunopharmacologists, Abstract 96.

71. Kapás L, Payne L, Obál F Jr, Opp MR, Johannssen L, Krueger JM. (1991) Hypnogenic

effects of interleukin-1 persist in diabetic rats. International Society of Immunopharmacologists, Abstract 28.

72. Krueger JM. (1991) Infections, cytokines and sleep. 3rd Milano International Symposium

“Sleep Hormones and Immunological System”, Abstract p 18.

73. Hong L, Johannsen L, Krueger JM. (1991) Modulation of human leukocyte antigen DR (HLADR) expression by interferon gamma and other cytokines in glioblastoma cells. Sleep Res 20A: 106.

74. Kapás L, Opp MR, Kimura-Takeuchi M, Krueger JM. (1991) Peripheral prostaglandins do not mediate the hypnogenic effects of interleukin-1. Sleep Res 20A: 35.

75. Opp MR, Payne L, Krueger JM. (1991) Somnogenic responses of rabbits and rats to an

interleukin-1 fragment. Sleep Res 20A: 193.

76. Kimura-Takeuchi M, Majde JA, Toth LA, Krueger JM. (1991) Hypnogenic tolerance to influenza virus is induced by double-stranded RNA in rabbits. Sleep Res 20A: 428.

77. Toth LA, Krueger JM. (1991) Clinical correlates of sleep patterns after bacterial challenge. Sleep Res 20A: 450.

78. Johannsen L, Krueger JM. (1991) Somnogenic activity of pseudomurein in rabbits. Sleep Res 20A: 145.

79. Payne L, Obál F Jr, Krueger JM. (1991) Neutralization of endogenous growth hormone-releasing hormone with GRF-antibodies suppresses interleukin-1 induced growth hormone secretion. Sleep Res 20A: 194.

80. Krueger JM, Kapás L, Opp MR, Obál F Jr. (1991) Effects of prostaglandin E2 and D2 on rabbit sleep. Sleep Res 20A: 151.

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81. Kapás L, Cady AB, Opp MR, Postlethwaite AE, Seyer JM, Krueger JM. (1991)

Somnogenic and pyrogenic activity of tumor necrosis factor-1 (TNF), TNF and

fragments of TNF. Soc Neurosci Abstr 17: 882.

82. Kimura-Takeuchi M, Majde JA, Toth LA, Krueger JM. (1991) Influenza virus and poly I:C enhance antiviral activity in rabbit sera, but not in rabbits tolerized to the virus. Soc Neurosci Abstr 17: 832.

83. Obál F Jr, Payne L, Kapás L, Opp MR, Alföldi P, Krueger JM. (1991) Growth hormone-releasing (GHRH) in sleep regulation. Sleep Res 20A: 192.

84. Hong L, Opp MR, Krueger JM. (1991) Interleukin-1 (IL-1)-induced intercellular adhesion

molecule (ICAM-1) expression is blocked by IL1- receptor antagonists (IL1ra). Soc Neurosci Abstr 17: 1198.

85. Toth LA, Krueger JM. (1991) Immune competence influences sleep after microbial challenge. Soc Neurosci Abstr 17: 1203.

86. Krueger JM, Opp MR. (1991) Cytokines and sleep mechanisms. “The Effects of Cytokines on the Nervous System” Symposium, Abstract p 10.

87. Payne L, Obál F Jr, Krueger JM. (1991) Interleukin-1 induced GH secretion is suppressed by neutralization of endogenous GHRH using GRF-antibodies. Soc Neurosci Abstr 17: 914.

88. Kimura-Takeuchi M, Majde JA, Toth LA, Krueger JM. (1991) Virally-induced sleep and physiological tolerance in rabbits. Jpn J Psychiat Neurol 45: 960-961.

89. Majde JA, Kimura-Takeuchi M, Krueger JM. (1991) Physiological hyporesponsiveness to influenza virus is induced by dsRNA and associated with absence of antiviral activity. Cytokine 3: 511.

90. Krueger JM. (1992) Interaction of cytokines with the hypothalamic-pituitary axis. Keystone Symposium, Abstract.

91. Imeri L, Opp MR, Krueger JM. (1992) A soluble interleukin-1 receptor attenuates interleukin-1-induced sleep and fever. Sleep Res 21: 31.

92. Opp MR, Krueger JM. (1992) Interleukin-1 antibodies reduce NREMS and attenuate NREMS rebound after sleep deprivation in the rabbit. Sleep Res 21: 323.

93. Kapás L, Shibata M, Krueger JM. (1992) Suppression of sleep after systemic or central injections of N-nitro-L-arginine, an inhibitor of nitric oxide synthesis. Sleep Res 21: 34.

94. Toth LA, Krueger JM. (1992) Clinical correlates of sleep patterns after bacterial challenge. Sleep Res 21: 315.

95. Kapás L, Shibata M, Krueger JM. (1992) Inhibition of nitric oxide synthesis suppresses sleep in rabbits. J Sleep Res 1: 111.

96. Kimura-Takeuchi M, Majde JA, Toth LA, Krueger JM. (1992) Somnogenic action of beta interferon: effects in influenza virus-tolerant rabbits. J Sleep Res 1: 115.

97. Toth LA, Kimura-Takeuchi M, Krueger JM. (1992) Sleep alterations during infectious diseases: Immunological influences. Contemporary Topics in Lab Animal Science; Vol 31(4), p 30.

98. Opp MR, Krueger JM. (1992) IL1- antibodies reduce sleep and attenuate IL1- induced enhancement of sleep in the rat. Soc Neurosci Abstr 18: 1227.

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99. Kapás L, Shibata M, Krueger JM. (1992) Inhibition of nitric oxide (NO) synthesis suppresses spontaneous sleep and transiently delays interleukin-1 (IL-1)-induced sleep but not fever. Soc Neurosci Abstr 18: 881.

100. Kimura-Takeuchi M, Majde JA, Toth LA, Opp MR, Krueger JM. (1992) Human and rabbit interferons induce sleep in rabbits. Soc Neurosci Abstr 18: 1227.

101. Imeri L, Opp MR, Krueger JM. (1992) Interleukin-1 (IL-1) induced expression of intercellular adhesion molecule-1 (ICAM-1) is antagonized by a soluble IL-1 receptor. Soc Neurosci Abstr 18: 1013.

102. Obál F Jr, Payne L, Kacsóh B, Alföldi P, Opp MR, Kapás L, Krueger JM. (1992) Promotion of REM sleep by prolactin in the male rat. J Sleep Res 1: 163.

103. Imeri L, Krueger JM. (1993) Effects of a soluble interleukin-1 receptor on muramyl dipeptide induced sleep and fever. Eur J Physiol Pflügers Arch 424: R26.

104. Fang J, Payne L, Krueger JM. (1993) Effects of pituitary adenylate cyclase-activating polypeptide on sleep in rats. Sleep Res 22: 517.

105. Opp MR, Krueger JM. (1994) Interleukin-1 antibodies reduce NREMS and attenuate NREMS rebound after sleep deprivation in the rat. Sleep Res 22: 598.

106. Kapás L, Krueger JM. (1993) Effects of naloxone pretreatment on interleukin-1 induced sleep and fever. Sleep Res 22: 435.

107. Hong L, Imeri L, Opp MR, Krueger JM. (1993) Intercellular adhesion molecule-1 expression induced by IL-1 beta or an IL-1 beta fragment is blocked by an IL-1 receptor antagonist and a soluble IL-1 receptor. Sleep Res 22: 480.

108. Kimura-Takeuchi M, Majde JA, Toth LA, Opp MR, Krueger JM. (1993) Somnogenic

actions of human recombinant interferon and rabbit interferon / in rabbits. Sleep Res 22: 437.

109. Fincher EF, Opp MR, Johannsen L, Krueger JM. (1993) Primary cultures of murine microglia process staphylococcus aureus into somnogenic and pyrogenic components. Sleep Res 22: 477.

110. Toth LA, Opp MR, Krueger JM. (1993) Modulation of microbially-induced sleep alterations by sleep deprivation. Sleep Res 22: 603.

111. Obál F Jr, Payne L, Opp MR, Kapás L, Alföldi P, Krueger JM. (1993) Growth hormone releasing hormone is a physiological sleep factor. Sleep Res 22: 503.

112. Kapás L, Shibata M, Krueger JM. (1993) Inhibition of nitric oxide synthesis results in long-lasting sleep loss in rats. Sleep Res 22: 8.

113. Kimura-Takeuchi M, Majde JA, Toth LA, Krueger JM. (1993) Effects of recombinant interferons on sleep in rabbits. Sleep Res 22: 36.

114. Kapás L, Kimura M, Fang J, Krueger JM. (1993) Microinjection of nitric oxide synthesis inhibitor into the brainstem suppresses sleep in rats. Soc Neurosci Abstr 19: 1814.

115. Krueger JM. (1993) Central cytokines and sleep. J Immunol 150: 82A.

116. Kimura M, Toth LA, Cady AB, Majde JA, Krueger JM. (1993) Acute-phase responses of rabbits to endotoxin and poly I:C. Soc Neurosci Abstr 19: 97.

117. Toth LA, Opp MR, Krueger JM. (1993) Sleep deprivation differentially modulates bacterially-induced sleep enhancement in rabbits. Soc Neurosci Abstr 19: 569.

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118. Fang J, Obál F Jr, Payne L, Krueger JM. (1993) Growth hormone-releasing hormone is involved in interleukin-1 (IL-1)-induced sleep in rats. Soc Neurosci Abstr 19: 573.

119. Kimura M, Krueger JM. (1993) Effects of recombinant human interferons on sleep in rabbits. 3

rd International Mochida Memorial Symposium “Horizon in Cytokine

Research”, Abstract.

120. Bredow S, Krueger JM. (1993) Molecular approaches to humoral regulation of sleep. Sleep Res 22: 476.

121. Kimura M, Majde JA, Toth LA, Krueger JM. (1993) Influenza virus-induced sleep and interferons. Interferon Res 13: 5169.

122. Krueger JM, Opp MR. (1993) Interleukin-1: involvement in sleep regulation. 19th CINP

Congress, Abstract.

123. Fang J, Sanborn CK, Majde JA, Krueger JM. (1994) Sleep changes induced by influenza virus injection in mice. Sleep Res 23: 358.

124. Opp MR, Krueger JM. (1994) Somnogenic actions of interleukin-2: real or artifact. Sleep Res 23: 26.

125. Obál F Jr, Floyd R, Kapás L, Fang J, Alföldi P, Krueger JM. (1994) Effects of systemic growth hormone-releasing hormone on sleep in hypophysectomized rats. J Sleep Res 3: 182.

126. Knefati M, Kapás L, Bourcier T, Krueger JM. (1994) Acidic fibroblast growth factor but not basic FGF induces sleep in rabbits. Sleep Res 23: 12.

127. Fincher E, Pabst M, Krueger JM. (1994) Interleukin-1 is degraded by neutrophils but not by monocytes or microglia. J Sleep Res 3: 80.

128. Takahashi S, Tooley D, Kapás L, Seyer J, Krueger JM. (1994) A soluble tumor necrosis factor binding protein and its fragment suppress spontaneous sleep in rabbits. Sleep Res 23: 39.

129. Kapás L, Krueger JM. (1994) The effects of a nitric oxide donor, S-nitroso-N-acetylpenicillamine (SNAP) on sleep in rats. Sleep Res 23: 11.

130. Kapás L, Krueger JM. (1994) Anti-tumor necrosis factor antibody suppresses spontaneous NREM sleep in rats. J Sleep Res 3: 121.

131. Kapás L, Krueger JM. (1994) Involvement of nitric oxide in sleep regulation. J Sleep Res 3: 121.

132. Bredow S, Kacsóh B, Obál F Jr, Krueger JM. (1994) VIP and PACAP induce PRL mRNA expression in rat hypothalamus. J Sleep Res 3: 32.

133. Kapás L, Krueger JM. (1994) Intracerebroventricular (I.C.V.) injection of the nitric oxide donors SNAP and SIN-1 induces sleep in rats. Soc Neurosci Abstr 20: 157.

134. Fang J, Renegar KB, Majde JA, Krueger JM. (1994) Influenza viral infection induces sleep changes in mice. Soc Neurosci Abstr 20: 157.

135. Takahashi S, Kapás L, Fang J, Krueger JM. (1994) Anti-tumor necrosis factor antibody suppresses spontaneous sleep in rabbits. Soc Neurosci Abstr 20: 157.

136. Bredow S, Kacsóh B, Obál F Jr, Krueger JM. (1994) Prolactin mRNA expression in the rat hypothalamus after VIP or PACAP injection. Sleep Res 23: 4.

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137. Fincher EF, Pabst M, Krueger JM. (1994) Interleukin-1 is degraded by neutrophils but not by monocytes or microglia. Sleep Res 23: 58.

138. Kimura M, Majde JA, Toth LA, Krueger JM. (1994) Effects of recombinant human

interferon and on sleep in rabbit. Jpn J Psych Neurol 48: 181.

139. Takahashi S, Seyer J, Krueger JM. (1995) Inhibition of interleukin-1 (IL-1) attenuates muramyl dipeptide (MDP)-induced sleep in rabbits. FASEB J Abstr.

140. Takahashi S, Seyer J, Krueger JM. (1995) An interleukin-1 receptor fragment inhibits spontaneous sleep and muramyl dipeptide-induced sleep in rabbits. Sleep Res 24:19.

141. Takahashi S, Hansen DM, Seyer J, Krueger JM. (1995) A soluble tumor necrosis factor (TNF) receptor fragment, TNFR-(159-178), suppresses normal sleep and muramyl dipeptide-induced sleep in rabbits. Sleep Res 24: 18.

142. Fang J, Gatewood C, Majde JA, Renegar KB, Krueger JM. (1995) Differential effects of total and upper airway influenza virus infection on sleep. Sleep Res 24: 28.

143. Kapás L, Obál F Jr, Book AA, Schweitzer JB, Wiley RG, Krueger JM. (1995) The effects of lesion of nerve growth factor receptive neurons on sleep. Sleep Res 24: 8.

144. Ayers NA, Kapás L, Krueger JM. (1995) Brain nitric oxide synthase activity and sleep. Sleep Res 24: 36.

145. Takahashi S, Kapás L, Hansen M, Zhang J, Seyer J, Krueger JM. (1995) An interleukin-

1 (IL-1) soluble receptor fragment inhibits IL-1-induced sleep and non-rapid-eye-movement sleep rebound after sleep deprivation in rabbits. Sleep Res 24A: 457.

146. Roky R, Kapás L, Fang J, Krueger JM. (1995) Restricted feeding to the light period affects the circadian rhythm of sleep and brain temperature in the rat. Sleep Res 24A: 540.

147. Bredow S, Fang J, Guha-Thakurta N, Majde JA, Krueger JM. (1995) Synthesis of an influenza double-stranded RNA-oligomer that induces fever and sleep in rabbits. Sleep Res 24A: 101.

148. Fincher E, Johannsen L, Krueger JM. (1995) While digesting bacteria, microglia release muramyl peptides that stimulate cytokine production. Sleep Res 24A: 104.

149. Kapás L, Ayers N, Krueger JM. (1995) Circadian variation in brain nitric oxide synthase activity. Sleep Res 24A: 106.

150. Kapás L, Ayers N, Krueger JM. (1995) Cytosolic protein concentrations of various brain regions have a circadian rhythm. Sleep Res 24A: 105.

151. Takahashi S, Kapás L, Wang Y, Seyer J, Krueger JM. (1995) Inhibition of tumor necrosis factor attenuates sleep rebound after sleep deprivation. Soc Neurosci Abstr 21: 454.

152. Ayers N, Kapás L, Krueger JM. (1995) Circadian cycling of nitric oxide synthase (NOS) activity and cytosolic protein content in rat brain. Soc Neurosci Abstr 21: 868.

153. Kapás L, Krueger JM. (1995) The effects of nitric oxide donors SIN-1 and SNAP on EEG power spectrum in rats. Soc Neurosci Abstr 21: 451.

154. Krueger JM. (1995) Cytokines as regulators of sleep. 15th International Symposium

“UOEH Occupational Health - Time Space”, Abstract p 27.

155. Krueger JM. (1995) Somnogenic actions of cytokines. 5th Naito Conference “Neuro-

Immuno-Endocrine Networks II”, Abstract pp 14-15.

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156. Kimura M, Kapàs L, Krueger JM. (1995) Oxidized glutathione promotes NREM sleep in rabbits. Psych Clin Neurosci 49: S22.

157. Krueger JM, Kapás L, Takahashi S. (1995) Separation of cytokine-induced fever and sleep. 10

th International Symposium “Pharmacology Thermore”, Abstract.

158. Takahashi S, Kapás L, Seyer J, Krueger JM. (1996) Systemic administration of an interleukin-1 soluble receptor fragment inhibits spontaneous non-rapid eye movement sleep. Sleep Res 25: 32.

159. Takahashi S, Kapás L, Seyer J, Wang Y, Krueger JM. (1996) Inhibition of tumor necrosis factor attenuates the sleep responses induced by increases in ambient temperature in rabbits. Sleep Res 25: 33.

160. Takahashi S, Kapás L, Fang J, Seyer J, Krueger JM. (1996) Somnogenic relationships between interleukin-1 and tumor necrosis factor. Sleep Res 25: 31.

161. Hansen MK, Kapás L, Krueger JM. (1996) The effects of food deprivation and refeeding on sleep, EEG slow wave activity and brain temperature. Sleep Res 25: 45.

162. Beranek L, Obál F Jr, Bodosi B, Taishi P, Laczi F, Krueger JM. (1996) Inhibition of non-REM sleep in response to a long-acting somatostatin analogue, Sandostatin, in the rat. J Sleep Res 5: 14.

163. Obál F Jr, Krueger JM. (1996) The growth-hormone (GH)-releasing hormone (GHRH)-GH-insulin-like growth factor-1 (IGF-1) in sleep regulation. J Sleep Res 5: 158.

164. Obál F Jr, Kacsóh B, Guha-Thakurta N, Bredow S, Krueger JM. (1996) Sleep in rats bearing transplanted pituitaries under the kidney capsule. J Sleep Res 5: 158.

165. Takahashi S, Kapás L, Krueger JM. (1996) Tumor necrosis factor and sleep regulation. J Sleep Res 5: 225.

166. Floyd R, Kapás L, Krueger JM. (1996) Central infusion of nitric oxide decreases natural killer cell activity. J Sleep Res 5: 65.

167. Fang J, Renegar KB, Kapás L, Wang Y, Krueger JM. (1996) The IL1 Type I receptor and the TNF 55 kD receptor are involved in sleep regulation. J Sleep Res 5: 62.

168. Bredow S, Obál F Jr, Guha-Thakurta N, Taishi P, Krueger JM. (1996) Hypothalamic

GHRH mRNA and TNF mRNA levels are higher during the day than night. Soc Neurosci Abstr 22: 146.

169. Fang J, Kapás L, Wang Y, Krueger JM. (1996) The TNF 55 kD receptor and the IL-1 type I receptor are involved in physiological sleep regulation. Soc Neurosci Abstr 22: 147.

170. Takahashi S, Gala S, Kapás L, Krueger JM. (1996) Nerve growth factor enhances sleep in rabbits. Soc Neurosci Abstr 22: 147.

171. Zhang J, Obál F Jr, Fang J, Collins BJ, Krueger JM. (1996) Reduction in non-rapid eye movement sleep (NREMS) in human growth hormone (hGH) transgenic mice. Soc Neurosci Abstr 22: 147.

172. Kapás L, Hansen MK, Chang HY, Krueger JM. (1996) Sleep responses to systemic injections of lipopolysaccharide are attenuated in vagotomized rats. 3

rd International

NIM Congress, Proceedings p 99.

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173. Hansen MK, Kapás L, Krueger JM. (1996) Blockade of cafeteria diet-induced sleep by subdiaphragmatic vagotomy in rats. 3

rd International NIM Congress, Proceedings p

99.

174. Bredow S, Guha-Thakurta N, Obál F Jr, Floyd RA, Taishi P, Krueger JM. (1996) TNF mRNA levels in normal rat brain change across the day. 3

rd International NIM Congress,

Proceedings p 70.

175. Floyd RA, Henry J, Krueger JM. (1996) Circadian variation of TNF in different areas of the rat brain. 3

rd International NIM Congress, Proceedings p 71.

176. Floyd RA, Kapás L, Krueger JM. (1996) Central nitric oxide decreases splenic natural killer cell activity. 3

rd International NIM Congress, Proceedings p 94.

177. Zhang J, Obál F Jr, Fang J, Collins BJ, Krueger JM. (1996) Change in sleep pattern in human growth hormone (hGH) transgenic mice. 3

rd International NIM Congress,

Proceedings p 100.

178. Fang J, Kapás L, Wang Y, Krueger JM. (1996) The 55-kD receptor and the IL-1 type I receptor are involved in sleep regulation. 3

rd International NIM Congress, Proceedings

p 100.

179. Fang J, Wang Y, Krueger JM. (1997) The TNF 55-kD receptor and the IL-1 type I receptor are involved in physiological sleep regulation. Sleep Res 26: 73.

180. Hansen MK, Krueger JM. (1997) Subdiaphragmatic vagotomy attenuates interleukin-1-induced sleep. Sleep Res 26: 75.

181. Kapás L, Hansen MK, Chang H-Y, Krueger JM. (1997) The somnogenic effects of lipopolysaccharide are attenuated in vagotomized rats. Sleep Res 26:77.

182. Hansen MK, Taishi P, Chen Z, Krueger JM. (1997) Cafeteria-feeding results in increased

interleukin-1 mRNA expressed in rat liver. Soc Neurosci Abstr 23: 1515.

183. Zhang J, Obál F Jr, Fang J, Krueger JM. (1997) Non-rapid eye movement sleep (NREMS) was enhanced by microinjection of growth hormone-releasing hormone (GHRH) into the preoptic area in rats. Soc Neurosci Abstr 23: 1067.

184. Kushikata T, Fang J, Wang Y, Krueger JM. (1997) Interleukin-4 attenuates spontaneous sleep in rabbits. Soc Neurosci Abstr 23: 792.

185. Chen Z, Fang J, Gardi J, Krueger JM. (1997) Sleep-deprivation induces activation of nuclear factor-kB. Soc Neurosci Abstr 23: 792.

186. Krueger JM, Fang J, Obál F Jr. (1998) Knockout and transgenic mice implicate IL1, TNF and GHRH in sleep regulation. J Sleep Res 7: 141.

187. Gardi J, Obál F Jr, Zhang J, Fang J, Krueger JM. (1998) Diurnal and sleep deprivation-induced changes in the GHRH contents of the rat hypothalamus. J Sleep Res 7: 97.

188. Taishi P, Chen Z, Obál F Jr, Hansen MK, Zhang J, Fang J, Krueger JM. (1998) Sleep

deprivation up-regulates interleukin-1 mRNA in the rat brain. J Sleep Res 7: 270.

189. Fang J, Krueger JM. (1998) Sleep is reduced in mice without TNF 55 kD receptor and IL-1 type I receptor. J Sleep Res 7: 82.

190. Chen Z, Krueger JM. (1998) Nuclear factor Kappa B (NFB) in sleep regulation. J Sleep Res 7: 44.

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191. Zhang J, Chen Z, Taishi P, Obál F Jr, Krueger JM. (1998) Sleep deprivation enhances hypothalamic GHRH mRNA. J Sleep Res 7: 311.

192. Beranek L, Hajdu I, Taishi P, Gardi J, Obál F Jr, Krueger JM. (1998) Sleep alterations elicited by intracerebral somatostatinergic stimulation. J Sleep Res 7: 23.

193. Obál F Jr, Kapás L, Krueger JM. (1998) Promotion of non-REM sleep by albumin in young rats. J Sleep Res 7: 189.

194. Obál F Jr, Fang J, Krueger JM. (1998) Prolactin in sleep regulation. J Sleep Res 7: 188.

195. Bodosi B, Komlódi J, Gardi J, Taishi P, Fang J, Obál F Jr, Krueger JM. (1998) Ether stress induces REM sleep. J Sleep Res 7: 28.

196. Kushikata T, Chen Z, Fang J, Wang Y, Krueger JM. (1998) Epidermal growth factor (EGF) enhances spontaneous sleep in rabbits. Sleep 21: 28.

197. Takahashi S, Krueger JM. (1998) Inhibition of tumor necrosis factor and interleukin-1 attenuate physiological sleep in rabbits. Soc Neurosci Abstr 24: 938.

198. Taishi P, Chen Z, Obál F Jr, Hansen MK, Fang J, Krueger JM. (1998) Sleep deprivation

upregulates interleukin-1 mRNA in rat brain. Soc Neurosci Abstr 24: 1431.

199. Hansen MK, Krueger JM. (1998) Gadolinium chloride pretreatment prevents cafeteria diet-induced sleep in rats. Soc Neurosci Abstr 24: 2078.

200. Kushikata T, Fang J, Krueger JM. (1998) Brain derived neurotropic factor (BDNF) increases spontaneous sleep in rabbits. Soc Neurosci Abstr 24: 693.

201. Gardi J, Obál F Jr, Taishi P, Speth RC, Kacsóh B, Krueger JM. (1999) Sleep in GHRH receptor-deficient dwarf rats. Sleep 22: 531.

202. Kushikata T, Fang J, Krueger JM. (1999) Neurotrophin-3 (NT-3) enhances spontaneous sleep in rabbits. Sleep 22: 576.

203. Hajdu I, Beranek L, Gardi J, Taishi P, Obál F Jr, Krueger JM. (1999) Sleep and behavioral responses to somatostatinergic stimulation. Sleep 22: 577.

204. Chen L, Fang J, Krueger JM. (1999) Whisker activity during wakefulness influences the EEG during subsequent sleep in rats. Soc Neurosci Abstr 25: 1613.

205. Rehman A, Krueger JM. (1999) Cloning and expression of peptidoglycan recognition protein (PGRP) in the brain and spleen of Rattus nervegicas. Soc Neurosci Abstr 25: 1445.

206. Alt J, Fang J, Rehman A, Harding JW, Wright JW, Krueger JM. (1999) Metalloproteinase-9 (MMP) is upregulated in the barrel field cortex after a whisker cut. Soc Neurosci Abstr 25: 883.

207. Guan Z, Churchill L, Fang J, Krueger JM. (1999) Sleep deprivation increases glutamate decarboxylase mRNA levels within the barrel cortex 6 hours after whiskers are cut. Soc Neurosci Abstr 25: 1614.

208. Kushikata T, Fang J, Krueger JM. (1999) An NFB inhibitory peptide inhibits sleep. Soc Neurosci Abstr 25: 1134.

209. Krueger JM, Obál F Jr, Fang J. (1999) Humoral regulation of sleep: molecular and genetic approaches. Sleep Res OnLine 2(Supp l): 685.

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210. Krueger JM, Obál F Jr, Fang J. (1999) Sleep is a fundamental property of neuronal groups. Sleep Res OnLine 2(Supp l): 686.

211. Krueger JM, Obál F Jr, Fang J. (1999) Cytokines and growth factors in sleep regulation. Sleep Res OnLine 2(Supp l): 684.

212. Bodosi B, Obál F Jr, Gardi J, Fang J, Krueger JM. (1999) Hypophysectomey and antiserum against prolactin block ether stress-induced REM sleep. Sleep Res OnLine 2(Supp l): 124.

213. Obál F Jr, Krueger JM. (1999) Endocrine modulation of sleep via GHRH. Sleep Res OnLine 2(Supp 1): 707.

214. Gardi J, Speth RC, Taishi P, Kacsóh B, Obál F Jr, Krueger JM. (1999) GHRH, GHRH receptor and sleep in the dw/dw dwarf rat. Endocrinology Society’s 81

st Annual

Meeting, Abstract p 379.

215. Hajdu I, Obál F Jr, Gardi J, Beranek L, Laczi F, Krueger JM. Drinking and vasopressin secretion to somatostatinergic stimulation are mediated by angiotensin II.

216. Majde JA, Rehman A, Ye X, Krueger JM. Expression of the influenza viral acute phase response precedes extrapulmonary dissemination of virus.

217. Guan Z, Churchill L, Fang J, Rehman A, Memet S, Israel A, Krueger JM. (1999) NFkB increases within the somatosensory pathway after a unilateral whisker cut in mice: a model of synaptic plasticity to test sleep function. The Physiologist 42(5): A-4.

218. Kubota T, Fang J, Krueger JM. (1999) Transforming growth factor B1 inhibits spontaneous sleep in rabbits. APS Conference, The Physiologist 42(5): A-4.

219. Chen L, Fang J, Krueger JM. (1999) EEG activity during sleep is changed by a whisker cut in rats. The Physiologist 42(5): A-2.

220. Brandt J, Churchill L, Guan Z, Fang J, Krueger JM. (1999) Sleep deprivation-induced upregulation of nerve growth factor (NGF) is dependent upon afferent input: the whisker cut as a model of plasticity to test sleep function. The Physiologist 42(5): A-2.

221. Churchill L, Guan Z, Brandt J, Fang J, Krueger JM. (1999) Glutamate decarboxylase (GAD)-immunoreactivity increases within the barrel field after a whisker cut in rats allowed to sleep: a model of synaptic plasticity to test sleep function. The Physiologist 42(5): A-2.

222. Gardi J, Fang J, Krueger JM. (1999) Sleep deprivation increases nerve growth factor and brain derived neurotrophic factor levels in cerebral cortex. The Physiologist 42(5): A-2.

223. Gonzalez MMC, Fang J, Hamilton SE, Nathanson NM, Krueger JM. (1999) Sleep patterns in M1 receptor knockout mice. The Physiologist 42(5): A-7.

224. Rehman A, Majde-Cottrell JA, Krueger JM. (1999) Peptidoglycan recognition protein (PGRP) mRNA levels are not induced during the acute phase response (APR) to influenza virus. The Physiologist 42(5): A-9.

225. Taishi P, Gardi J, Chen Z, Fang J, Kruger JM. (1999) Sleep deprivation increases the

expression of TNF mRNA and TNF55kD receptor mRNA in rat brain. The Physiologist 42(5): A-4.

226. Krueger JM. (1999) Cytokines and sleep control. The Physiologist 42(5): A-13.

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227. Rehman A, Taishi P, Fang J, Majde-Cottrell-JA, Krueger JM. (2000) Sleep deprivation induces peptidoglycan recognition protein (PGRP) in brain. Brain Behav Immunity 14: 123.

228. Kubota T, Fang J, Krueger JM. (2000) Effects of two inhibitory cytokines interleukin-13

(IL13) and transforming growth factor-beta 1 (TGF--1) on spontaneous sleep in rabbits. Brain Behav Immunity 14: 108.

229. Churchill L, Guan Z, Ellis G, Rehman A, Ye X, Memet S, Israel A, Fang J, Krueger JM.

(2000) Sleep deprivation increases translocation of nuclear factor kappa in specific

brain regions in kappa -lac Z transgenic mice. Sleep 23(Suppl 2: A18).

230. Brandt J, Churchill L, Fang J, Krueger JM. (2000) Sleep deprivation increases the

number of neurons that contain the p65 subunit of nuclear factor kappa within the lateral hypothalamus of the rats. Sleep 23(Suppl 2: A 249).

231. Guan Z, Churchill L, Ellis G, Rehman A, Ye X, Memet S, Israel A, Krueger JM. (2000) Sleep deprivation interferes with increased nuclear translocation of nuclear factor

kappa after a whisker cut. Sleep 23(Suppl 2: A 250).

232. Rehman A, Taishi P, Alt J, Fang J, Krueger JM. (2000) Peptidoglycan recognition protein (PGRP) transcripts increase during sleep deprivation. Sleep 23(Suppl 2: A 254).

233. Yujia W, Fang J, Krueger JM. (2000) Sleep deprivation enhances phosphorylation of CREB and ERK. Soc Neurosci Abstr 26: 1266.

234. Rehman A, De A, Taishi P, Teodecki EE, Krueger JM. (2000) Sleep deprivation

upregulates LITAF {Lipopolysaccharide (LPS)-induced Tumor Necrosis Factor-

(TNF-) Activating Factor} homologue, EET-1, in rats. Soc Neurosci Abstr 26: 2027.

235. Taishi P, Sanchez C, Wang Y, Fang J, Krueger JM. (2000) Sleep alters the expression of arc mRNA and BDNF mRNA. Soc Neurosci Abstr 26: 1758.

236. Kushikata T, Kubota T, Fang J, Krueger JM. (2000) Glial cell line-derived neurotrophic factor (GDNF) increases spontaneous sleep in rabbits. Soc Neurosci Abstr 26: 1758.

237. De A, Simasko SM, Krueger JM. (2000) TNF increases intracellular calcium responses to KCl and AMPA in primary cultures of fetal hippocampal neurons. Soc Neurosci Abstr 26: 1363.

238. Guan Z, Fang J, Krueger JM. (2000) Nuclear Factor Kappa B (NFB) is activated in the nucleus of solitary tract (NTS) and the hypoglossal nucleus after somnogenic doses of Interleukin-1 (IL1) given intraperitoneally (IP). Soc Neurosci Abstr 26: 816.

239. Brandt J, Churchill L, Guan Z, Fang J, Takahashi S, Krueger JM. (2000) Sleep deprivation upregulates nerve growth factor (NGF)-immunoreactivity in the barrel field

of rats but not nuclear factor kappa B (NFB) immunoreactivity. Soc Neurosci Abstr 26: 2027.

240. Churchill L, Brandt J, Guan Z, Fang J, Krueger JM. (2000) Whisker trim decreases the number of neurons immunoreactive for the p65 subunit of nuclear factor kappa B within the lateral hypothalamus only in rats that sleep. Soc Neurosci Abstr 26: 1756.

241. Rehman A, De A, Krueger JM. Interleukin-1 (IL1) and tumor necrosis factor (TNF) induce ECSIT (evolutionarily conserved signaling intermediate in Toll pathways) mRNA in hippocampal neurons.

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242. Obál F Jr, Fang J, Taishi P, Gardi J, Kacsóh B, Krueger JM. (2000) Sleep alterations in the GHRH receptor-deficient dwarf rat. J Sleep Res 9(Suppl): 141.

243. Churchill L, Guan Z, Brandt JA, Fang J, Krueger JM. (2001) Peripheral administration of

interleukin-1 increases nuclear factor kappa B activation in visceral tractus solitarius. Sleep 24: A142-A143.

244. De A, Simasko SM, Krueger JM. (2001) Effects of glutamate on the expression of tumor

necrosis factor alpha (TNF) in cultures of hypothalamic cells. Sleep 24: A150.

245. Alt J, Obál F Jr, Majde JA, Krueger JM. (2001) Impairment of the sleep responses to influenza infection in mice with a defective GHRH-receptor. Sleep 24: A144-A145.

246. Chen L, Fang J, Majde JA, Krueger JM. (2001) Effects of IFN and TNF on spontaneous sleep in mice. Sleep 24: A145.

247. Krueger JM. (2001) Cytokines and neuroendocrines in sleep regulation. Somnologie 5(Suppl 1): 5-6.

248. Kubota T, Fang J, Meltzer L, Krueger JM. (2001) Pregabalin enhances non-rapid eye movement and EEG slow-wave activity in rats. Soc Neurosci Abstr 27: 2245.

249. De A, Churchill L, Taishi P, Obál F Jr, Krueger JM, Simasko SM. (2001) Growth hormone-releasing hormone increases intracellular calcium in neurons cultured from fetal rat hypothalamus. Soc Neurosci Abstr 27: 1859.

250. Churchill L, Brandt JA, Rehman A, Krueger JM. (2001) Systemic injection of interleukin-1 beta increases tumor necrosis factor alpha mRNA levels within the nucleus tractus solitarius. Soc Neurosci Abstr 27: 1385.

251. Rehman A, De A, Krueger JM. (2001) Peptidoglycan recognition protein (PGRP)

transcripts are upregulated by tumor necrosis factor alpha (TNF) in primary cultures of rat hippocampal neurons. Soc Neurosci Abstr 27: 1670.

252. Chen L, Majde JA, Alt J, Kubota T, Krueger JM. (2001) The differential sleep response of inducible Nos knockout mice to influenza infection. Soc Neurosci Abstr 27: 1378.

253. Reid J, Meighan SE, Turner GD, Krueger JM, Harding JW, Wright JW. (2001) Paradoxial sleep deprivation impairs brain matrix metalloproteinase activity in rats trained in the circular water maze. Soc Neurosci Abstr 27: 833.

254. Simasko SM, Kubota T, De A, Krueger JM. (2001) Effect of acute and chronic alcohol on sleep in the rat. 24

th Annual RSA Scientific Meeting, Abstract.

255. Churchill L, De S, Taishi P, Broom L, Obál F Jr, Simasko SM, Krueger JM. (2002) Growth hormone-releasing hormone and interleukin-1beta increase calcium levels in GABAergic neurons cultured from rat fetal hypothalamus. Sleep 25: A128-A129.

256. Alt J, Obál F Jr, Majde JA, Krueger JM. (2002) GH replacement fails to normalize sleep responses to viral influenza infection in GHRH-Receptor deficient mice. Sleep 25: A175-A176.

257. Traynor TR, Alt J, Obál F Jr, Majde JA, Krueger JM. (2002) Sleep and body temperature in mice lacking a functional GHRH receptor. Sleep 25: A295.

258. Yoshida H, Krueger JM. (2002) A cyclooxygenase-2 inhibitor attenuates non-rapid eye movement sleep in rabbits. Sleep 25: A297-A298.

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259. Taishi P, Gardi J, Speth RC, Obál F Jr, Krueger JM. (2002) Sleep deprivation-induced changes in growth hormone releasing hormone receptor (GHRH-R) mRNA in rat hypothalamus. Sleep 25: A323-A324.

260. De A, Simasko SM, Taishi P, Churchill L, Krueger JM. (2002) Calcium responses to

growth hormone-releasing hormone and interleukin 1 in cultured hypothalamic neurons are developmentally regulated. Sleep 25: A171-A172.

261. Chen L, Madje JA, Krueger JM. (2002) Spontaneous sleep in neuronal and inducible nitric oxide synthase knockout mice. Sleep 25: A170-A171.

262. Peterfi Z, Spiegel G, Obál F Jr, Churchill L, Krueger JM, Parducz PA. (2002) Diurnal variations in C-Fos protein in rat hypothalamic nuclei: effects of gender and sleep deprivation. J Sleep Res 11(Suppl 1): 174-175.

263. Taishi P, De A, Teodecki L, Obál F Jr, Krueger JM. (2002) Interleukin-1 beta induces expression of GHRH receptor mRNA in neurons. J Sleep Res 11(Suppl 1): 221-222.

264. Hajdu I, Szentirmai É, Obál F Jr, Krueger JM. (2002) Brain areas mediating drinking and inhibition of sleep to the somatostatin agonist, octreotide. J Sleep Res 11(Suppl 1): 93.

265. Gardi J, Szentirmai É, Hajdu I, Obál F Jr, Krueger JM. (2002) Sleep, behavioral, and hypothalamic GHRH and angiotensin responses to the somatostatin agonist, octreotide. J Sleep Res 11(Suppl 1): 77-78.

266. Kubota T, Kushikata T, Takahashi S, Krueger JM. (2002) Brain cytokine network and sleep regulation. J Sleep Res 11(Suppl 1): 128-129.

267. Alt J, Obál F Jr, Gardi J, Krueger JM. (2002) Sleep in mutant mice with non-functional GHRH receptor: responses to GHRH, ghrelin, and somatostatin. J Sleep Res 11(Suppl 1): 3-4.

268. Obál F Jr, Krueger JM. (2002) GHRH and sleep - animal models. J Sleep Res 11(Suppl 1): 66.

269. Krueger JM. (2002) Cytokines, sleep and infection. 5th International Congress of

International Society of Neuroimmunomodulation. Abstract Book p 10.

270. Churchill L, Cearley C, Biasell E, Sorg BA, Krueger JM. (2003) Time of day and peripheral cytokines impact extinction of cocaine-induced conditioned place preference. Sleep 26: A435.

271. Garcia-Garcia F, Cussen VA, Krueger JM. (2003) Sleep disturbances in the rotenone-animal model of Parkinson disease. Sleep 26: A332.

272. Obál F Jr, Hajdu I, Gardi J, Szentirmai É, Alt J, Krueger JM. (2003) GHRH mediates somatostatin actions on sleep. Sleep 26: A418.

273. Taishi P, Alt J, Churchill L, Obál F Jr, Krueger JM. (2003) Central administration of interleukin-1 beta increases growth hormone-releasing hormone receptor mRNA in the hypothalamus. Sleep 26: A416.

274. Traynor T, Seaman AP, Majde JA, Krueger JM. (2003) Interferon receptor type I deficient mice have reduced spontaneous REM sleep. Sleep 26: A72.

275. De A, Simasko SM, Krueger JM. (2003) AMPA-induced intracellular calcium responses

are inhibited by interferon in primary cultures of fetal hippocampal neurons. Sleep 26: A12-A13.

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276. Chen L, Majde JA, Krueger JM. (2003) Sleep characteristics in mice with targeted disruptions of neuronal or inducible nitric oxide synthase genes. 4

th ASRS Congress,

Abstract. (In press)

277. Taishi P, De A, Alt J, Obál F Jr, Krueger JM. (2003) Interleukin-1 beta induces expression of growth hormone-releasing hormone receptor mRNA in rat hypothalamic neurons. 4

th ASRS Congress, Abstract.

278. Yoshida H, Peterfi Z, Garcia-Garcia F, Krueger JM. (2003) Unilateral microinjection of

TNF onto the cortex induces EEG asymmetry. 4th ASRS Congress, Abstract.

279. Krueger JM, Obál F Jr. (2003) Function of sleep. 4th ASRS Congress, Abstract.

280. Cearley C, Churchill L, Sorg BA, Krueger JM. (2003) Time of day impacts cytokine mRNA levels after extinction of cocaine-induced conditioned place reference. Sleep 26: A435.

281. Bohnet S, Majde JA, Traynor T, Krueger JM. (2004) Increased expression of hypothalamic orexin mRNA is associated with spontaneous REM sleep suppression in mice deficient in the Interferon Type I receptor. Sleep 27: A378.

282. Chen L, Taishi P, Duricka D, Krueger JM. (2004) Elevated brain prolactin mRNA levels in mice with suppressed neuronal nitric oxide synthase activity. Sleep 27: A379.

283. Duricka D, Earnest DJ, Krueger JM. (2004) Synchronized SCN cell cultures exhibit rhythmic expression of Per1 and TNF alpha mRNAs. Sleep 27: A380-A381.

284. García-García F, Obál F Jr, Taishi P, Brown R, Horseman N, Krueger JM. (2004) Sleep in PRL deficient mice: effect of sleep deprivation and PRL replacement. Sleep 27: 137.

285. Churchill L, Garcia-Garcia F, Krueger JM. (2004) Local application of Tumor Necrosis

Factor- increases Fos and Interleukin 1-cortex. Sleep 27: A3.

286. Rajapakse I, Manoranjan V, Campbell KB, Rector DM, Krueger JM. (2004) Ultradian sleep rhythms: mathematical model. Sleep 27: A3-A4.

287. Nelson SE, Duricka D, Campbell KB, Krueger JM. (2004) Homer1a mRNA levels increase during sleep loss. Sleep 27: A136-A137.

288. Bohnet S, Tang C, Sula MM, Taishi P, Rehman A, Krueger JM. (2004) The sequencing

of rat CREB-binding Protein (CBP) after its up-regulation by Interleukin 1. Sleep A378-A379.

289. Taishi P, Peterfi Z, De A, Obál F Jr, Krueger JM. (2004) Interleukin-1 beta treatment up-regulates hypothalamic cytokines and neurotrophin mRNAs in vivo and in vitro. Sleep 27: A380.

290. Taishi P, Brandt J, Cearley C, Churchill L, Krueger JM. (2004) Systemic administration of Interleukin-1-beta or Tumor Necrosis Factor-alpha increases cytokine mRNA levels in the nucleus tractus solitarius and somatosensory cortex. Sleep 27: A379-A380.

291. Yasuda T, Yoshida H, Garcia-Garcia F, Krueger JM. (2004) Local application of IL-1 induces asymmetry in the slow wave sleep EEG. Sleep 27: A2-A3.

292. Krueger JM, Rector DM, Yasuda T, Yoshida H, Yasuda K, Churchill L, Obál F Jr. (2004) Local regulation of cortical sleep; activity dependency and cytokine involvement. J Sleep Res 13(Suppl 1).

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293. De A, Simasko SM, Krueger JM. (2004) Glutamate increases the expression and release

of TNF in primary cultures of fetal rat hypothalamic cells. J Sleep Res 13(Suppl 1).

294. Yasuda T, Yasuda K, Krueger JM. (2004) The effects of light/dark cycle on EEG slow wave power of the somatosensory cortex and visual cortex. J Sleep Res 13(Suppl 1).

295. Obál F Jr, Peterfi Z, Brown R, Taishi P, Krueger JM. (2004) Sleep in spontaneous dwarf rats. J Sleep Res 13(Suppl 1).

296. Taishi P, Peterfi Z, Brown R, Obál F Jr, Krueger JM. (2004) Expression of GHRH-related mRNAs in the brain of spontaneous dwarf rats. J Sleep Res 13(Suppl 1).

297. Bodosi B, Gardi J, Hajdu I, Szentirmai É, Obál F Jr, Krueger JM. (2004) Ghrelin and leptin responses to sleep deprivation and to reverse feeding schedule in rats. J Sleep Res 13(Suppl 1).

298. Gardi J, Bodosi B, Hajdu I, Szentirmai É, Obál F Jr, Krueger JM. (2004) Rhythms of ghrelin and leptin with respect to sleep and feeding in rats. J Sleep Res 13(Suppl 1).

299. Peterfi Z, Obál F Jr, Parducz A, Siklos L, Krueger JM. (2004) The neurotransmitters expressed in fos-positive hypothalamic neurons responsive to sleep deprivation or diurnal rhythm. J Sleep Res 13(Suppl 1).

300. Yasuda K, Churchill L, Blindheim K, Falter M, Yasuda T, Krueger JM. (2004) Local

unilateral application of IL1 into the barrel field induces asymmetries in Fos-immunoreactive. J Sleep Res 13(Suppl 1).

301. Churchill L, Yasuda K, Blindheim K, Falter M, Yasuda T, Krueger JM. (2004) Asymmetry

in Fos- and IL1-immunoreactivity induced by IL1 microinjection into the cortex implicates the cortical/thalamic circuitry involved in EEG asymmetry. J Sleep Res 13(Suppl 1).

302. Falter M, Yasuda K, Churchill L, Yasuda T, Krueger JM. (2005) Unilateral cortical application of interleukin 1β increases the number of nerve growth factor immunoreactive cells in the ipsilateral horizontal diagonal band. Sleep 28: A21-A22.

303. Blindheim K, Yasuda K, Churchill L, Yasuda T, Krueger JM. (2005) Unilateral cortical application of interleukin 1-β increases the number of FOS-immunoreactive nuclei in the prefrontal and secondary motor cortex. Sleep 28: A23.

304. Alt J, Taishi P, Duricka D, Bohnet S, Obál F Jr, Traynor T, Majde JA, Krueger JM. (2005) Elevated plasma corticosterone and decreased hypothalamic IL1β, CHRH R2 and GHRH receptor mRNAs are associated with sleep inhibition induced by influenza virus in lit/lit mice. Sleep 28: A342.

305. Szentirmai É, Hajdu I, Obál F Jr, Krueger JM. (2005) Ghrelin-induced sleep responses in ad libitum fed and food-restricted rats. Sleep 28: A32-A33.

306. Taishi P, Davis CJ, Harding JW, Wright JW, Krueger JM. (2005) Rapid eye movement sleep deprivation by the flower pot method increases cytokine mRNA levels in the rat hypothalamus. Sleep 28: A342-A343.

307. Biasell EI, Majde JA, Krueger JM. (2005) Intratracheal polyriboinosinic:polyribocytidylic acid (poly rI:rC) induces sleep but not body temperature or locomotor activity changes. Sleep 28: A42.

308. De A, Mukherjee S, Krueger JM, Simasko SM. (2005) Prenatal ethanol exposure changes nonrapid eye movement sleep in adult male rats. Sleep 28: A31.

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309. Traynor TR, Majde JA, Bohnet S, Krueger JM. (2005) The role of type I interferons in sleep and body temperature responses to influenza virus infection. Sleep 28: A41.

310. Majde JA, Traynor T, Bohnet S, Krueger JM. (2005) The role of type I interferons in sleep and body temperature responses in a model of acute viral infection. Sleep 28: A40-A41.

311. Guan X, Taishi P, Brown R, Krueger JM. (2006) State-specific asymmetries in EEG slow wave activity induced by local application of (S)-AMPA. Sleep 29: A8.

312. Bohnet S, Taishi P, Krueger JM. (2006) Microarray expression analysis of hypothalamus

mRNA after interleukin-1. Sleep 29: A358.

313. Churchill L, Rector DM, Yasuda K, Rojas MJ, Schactler S, Fix C, Hall S, Yasuda T, Krueger JM. (2006) Tumor necrosis factor α increases surface evoked potentials in the barrel field by whisker deflection during sleep in rats. Sleep 29: A12-A13.

314. Davis CJ, Wang M, Taishi P, Wright JW, Krueger JM. (2006) REM sleep loss affects plasticity-linked early immediate gene Homer1 isoforms in the rat hippocampus. Sleep 29: A359.

315. De A, Fix C, Hall S, Churchill L, Krueger JM. (2006) Growth hormone releasing hormone receptor-immunoreactive cells increase in the barrel field in response to whisker deflection in rats. Sleep 29: A9.

316. De A, Taishi P, Mukherjee S, Simasko SM, Krueger JM. (2006) Prenatal ethanol exposure alters TNFα-induced sleep responses in female rats. Sleep 29: A312-A313.

317. Fix C, Churchill L, Hall S, Krueger JM. (2006) The number of tumor necrosis factor α-immunoreactive cells increases in layer IV of the barrel field in response to whisker deflection in rats. Sleep 29: A11.

318. Jimenez L, Magrath P, Taishi P, Bohnet S, Krueger JM. (2006) Isoforms of GHRH receptor mRNA and GHRH mRNA in rat cortex. Sleep 29: A359.

319. Kay D, Taishi P, Krueger JM. (2006) Local application of short interfering RNA targeting tumor necrosis factor α (TNFα) induces state-specific asymmetries in EEG slow wave activity. Sleep 29: A360.

320. Leyva-Grado VH, Wu M, Churchill L, Majde JA, Krueger JM. (2006) Influenza virus increases the number of tumor necrosis factor α-(TNFα)-immunoreactive cells in the olfactory bulb following intranasal inoculation. Sleep 29: A13.

321. Majde JA, Bohnet S, Wu M, Szentirmai É, Churchill L, Krueger JM. (2006) Influenza virus rapidly enters the mouse brain after intranasal inoculation prior to onset of symptoms. Sleep 29: A310-A311.

322. Mukherjee S, Kazerooni M, De A, Krueger JM, Simasko SM. (2006) Chronic alcohol treatment disrupts circadian patterns of sleep in rats. Sleep 29: A312.

323. Szentirmai É, Krueger JM. (2006) Neuropeptide Y promotes wakefulness after central administration in rats. Sleep 29: A9.

324. Wang M, Taishi P, Guan X, De A, Liao F, Churchill L, Krueger JM. (2006) Short interfering RNA targeting tumor necrosis factor α (TNFα) inhibits expression of TNFα messenger RNA and immunoreactivity in vitro and in vivo. Sleep 29: A360.

325. Szentirmai É, Krueger JM. (2006) Ghrelin intrahypothalamic administration suppresses sleep in rats. Sleep 29: A9.

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326. Davis CJ, Bohnet S, Krueger JM. (2006) Sleep loss changes microRNA levels in the brain: a possible mechanism for state-dependent regulation of protein translation. Soc Neurosci Abstr 14:13.

327. Churchill L, Blindheim K, Krueger JM. (2006) Acute cocaine near dark onset increases the number of interleukin-1 beta immunoreactive glial cells in layer V of the prefrontal cortex of rats. Soc Neurosci Abstr 157.20, 32: 35.

328. MaGrath PM, Majde JA, Krueger JM. (2007) Changes in body temperature and locomotor activity responses to influenza virus infection in mice deficient in the dsRNA-binding toll-like receptor 3. Sleep 30: A33.

329. Szentirmai É, Kapás L, Sun Y, Smith RG, Krueger JM. (2007) Sleep responses to ghrelin, leptin and cholecystokinin in ghrelin knockout mice. Sleep 30: A18.

330. Szentirmai É, Kapás L, Sun Y, Smith RG, Krueger JM. (2007) Spontaneous sleep and response to sleep deprivation in ghrelin knockout mice. Sleep 30: A18-A19.

331. Davis CJ, Bohnet S, Krueger JM. (2007) Sleep loss affects microRNA expression in the rat hypothalamus. Sleep 30: A363.

332. Liao F, De A, Urza MJ, Krueger JM. (2007) GHRH increases cytoplasmic calcium levels in cultured cortical neurons. Sleep 30: A30.

333. Davis CJ, Bohnet S, Krueger JM. (2007) Let-7 microRNA expression in brain tissues from sleep deprived rats verified by strand-elongation PCR. Sleep 30: A363.

334. Jimenez L, Bohnet S, Krueger JM. (2007) GHRH, GHRH-R and Pit-1 mRNAs have diurnal rhythms in rat cortex. Sleep 30: A367.

335. Leyva-Grado VH, Wu M, Churchill L, Majde JA, Krueger JM. (2007) Increase of cytokine-immunoreactive cells in the olfactory bulb of mice after intranasal inoculation with influenza A virus. Sleep 30: A363.

336. Taishi P, Churchill L, Krueger JM. (2007) Sleep deprivation increases TNF protein (26 kDa) levels in the cortex. Sleep 30: A21.

337. Taishi P, Urza M, Jimenez L Krueger JM. (2008) Diurnal variations in purine P2X7 and P2Y1 receptors correlate with the sleep-wake cycle in the cortex. Sleep 31. A363

338. Clegern W, Szentirmai É, Rector DM, Panksepp J, Krueger JM. (2008) Voluntary sleep restriction in rats is associated with sleep rebound. Sleep 31. A122

339. Szentirmai É, Kapás L, Sun Y, Smith RG, Krueger JM. (2008) Severe impairment in sleep and thermoregulatory responses to metabolic challenges in preproghrelin knockout mice. Sleep 31: A2-A3.

340. Szentirmai É, Kapás L, Sun Y, Smith RG, Krueger JM. (2008) Food anticipatory activity in preproghrelin knockout mice. Sleep 31: A363.

341. Leyva-Grado VH, Williams TJ, Churchill L, Majde JA, Krueger JM. (2008) Somnogenic cytokines interleukin-1β and Tumor necrosis factor α increase in the piriform cortex and the hypothalamic arcuate nucleus following intranasal inoculation with influenza A virus. Sleep 31: A13-A14.

342. Ingalsbe K, Churchill L, De A, Krueger JM. (2008) Tumor necrosis factor alpha-, nerve growth factor-, and the neuronal nuclear protein-immunoreactivity are altered differentially in two areas of cortex depending on prior activity. Sleep 31: A12-A13.

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343. Churchill L, De A, Inglasbe K, Krueger JM. (2008) Whisker-stimulation increases the number of double labeled immunoreactive cells for nerve growth factor and interleukin-1 beta in the somatosensory cortex in rats. Sleep 31:A12.

344. Churchill L, De A, Hallett H, Inglsbe K, Nguyen K, Krueger JM. (2008) Time course of whisker-stimulation induced increases in tumor necrosis factor alpha-immunoreactive cells in the somatosensory cortex in rats. Sleep 31:A13.

345. Davis CJ, Wang M, Bohnet ST, Krueger JM. (2008) Diurnal rhythm of microRNA expression in the brain. Sleep 31:A362-A363.

346. De A, Churchill L, Simasko SM, Krueger JM. (2008) Prenatal alcohol exposure increases the number of tumor necrosis factor alpha-immunoreactive cells in the somatosensory cortex of adult female rats. Sleep 31:A13.

347. Bohnet SG, Sawatzki N, Majde JA, Churchill L, Krueger JM. (2009) Persistent brain infection of PR8 influenza at 48 and 96 hours post-infection. Sleep 32:A402.

348. Churchill L, Hallett H, Krueger JM. (2009) Dynamic expression of purine type II receptors (P2Y1 R) and their colocalization with interleukin-1beta and tumor necrosis factor alpha in rat pyramidal neurons. Sleep 32:A23.

349. Clinton JM, Bohnet SG, Davis CJ, Krueger, JM. (2009) Micro RNAs that change with sleep propensity target known sleep regulatory substances in vitro. Sleep 32:A402-A403.

350. Davis CJ, Clinton JS, Bohnet SG, Krueger JM. (2009) Microinjection of micro RNA analogs causes cortical electroencephalographic asymmetries in the rat. Sleep 32:A403.

360. Hallett H, Churchill L, Krueger JM. (2009) Interleukin-1β and nerve growth factor are differentially altered in the rat somatosensory cortex depending on time of day. Sleep 32:A21.

361. Hallett H, Churchill L, De A, Ingalsbe K, Krueger JM. (2009) Time course of whisker-stimulation-induced increases in interleukin-1 beta- and nerve growth factor-immunoreactive cells in rat somatosensory cortex. Sleep 32:A23.

362. Krueger JM, De A, Taishi P, Wang M, Jimenez L, Urza M, Szentirmai E, Bohnet S. (2009) An ATP agonist promotes and an ATP antagonist inhibits sleep. Sleep 32:A24.

363. Liao F, Taishi P, Krueger JM. (2009) Local cortical administration of a GHRH antagonist suppresses EEG delta wave power during NREMS. Sleep 32:A3.

364. Szentirmai É, Kapás L, Sun Y, Smith RG, Krueger JM. (2009) Arousal responses to fasting are blunted in ghrelin knockout mice. Sleep 32:A400.

365. Taishi P, Obál Jr F, Krueger JM. (2009) Interleukin-1-beta treatment up-regulates purine type 2 receptor mRNAs in rat somatosensory cortex. Sleep 32:A403.

366. Bayomy OF, Zielinski MR, Taishi P, Smith DE, Krueger JM (2011) The sleep regulatory role of interleukin-1 receptor accessory protein B in mice. Sleep 34:A46.

367. Zielinski MR, Taishi P, Krueger JM. (2011) CD73 in sleep regulation. Sleep 34:A14.

368. Davis CJ, Clinton JS, Bohnet SG, Krueger JM (2011) In vivo microRNA-138 inhibition suppresses sleep and delta power during the light phase. Sleep 34:A17.

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369. Dunbrasky D, Zielinski MR, Bohnet SG, Krueger JM. (2011) Vagal involvement in tumor necrosis factor alpha-induced sleep. Sleep 34:A53.

370. Honn KA, Davis CJ, Bohnet SG, Krueger JM. (2011) Gene expression in sleep-deprived purine type 2X7 receptor knockout mice. Sleep 34:A15.

371. Zielinski MR, Davis CJ, van Rooijen N, Krueger JM. (2011) Perivascular and meningeal macrophages affect sleep. Sleep 34:A8.

372. Boucher AL, Zielinski MR, Dinarello CA, Krueger JM. (2011) Mice with the human interleukin-37 transgene sleep less after sleep deprivation. Sleep 34:A44.

372. Bohnet SG, Majde JA, Hodgson NR, Krueger JM. (2011)Influenza-induced responses in mice with a functional Mx1 gene. Sleep 34:A17-A18.

373. Jewett K, Sengupta P, Kirkpatrick R, Clinton J, Krueger JM. (2011) Optogenetic stimulation enhances C-fos and interleukin-1 beta levels in cultured neurons. Sleep 34:A14.

374. Sengupta P, Davis C, Clinton J, Roy S, Krueger JM. (2011) Networks of cultured neurons show oscillatory dynamics. Sleep 34:A36-A37.

375. Souza G, Zielinski MR, Bohnet SG, Majde JA, Taishi P, Krueger JM. (2011) Prior immunization does not prevent human H1N1 influenza invasion into the olfactory bulb of mice. Sleep 34:A17.

376. Taishi P, Liao F, Smith DE, Krueger JM. (2011) Sleep affects brain-specific interleukin-1 (IL1) receptor accessory protein (AcPb) mRNA expression in rat SSctx. Sleep 34:A17.

377. Zielinski MR, Dinarello CA, Krueger JM. (2012) Mice transgenic for human interleukin-37 have attenuated sleep responses to lipopolysaccharide. Sleep 35:A26-A27.

378. Davis CJ, Clinton JM, Krueger JM. (2012) Inhibiton of select micro RNAs affects sleep and electroencephalographic slow wave activity. Sleep 35:A47.

379. Jewett KA, Sengupta P, Davis CJ, Krueger JM (2012) Altering neuronal firing by changing astrocyte-to-neuron ration in vitro. Sleep 35:A25.

380. Clinton JM, Davis CJ, Krueger JM (2012) Interleukin-37 transgenic mice are resistant to sleep deprivation-induced impairment of novelty recognition. Sleep 35:A35.

381. Roy S, Krueger JM, Jewett KA, Sengupta P, Davis C, Corrigan P. (2012) Sleep-reminiscent dynamics in isolated neuronal networks: Spatial characteristics. Sleep 35:A25.

382. Roy S, Krueger JM, Van Dogen H, Wan Y, Corrigan P. (2012). Mathematical analysis of sleep and cognitive performance using network models. Sleep 35:A438.

383. Taishi, P, Zielinski MR, Krueger JM (2012) Up-regulation of growth hormone releasing hormone receptor and pathogen pattern recognition receptors mRNAs in the olfactory bulb precede viral-induced sleep responses. Sleep 35:A35.

384. Oonk M, Davis CJ, Krueger JM, Wisor J, Van Dogen H. (2012) Within-session rat-psychomotor vigilance task performance after 24H sleep deprivation. Sleep 35:A74.

KRUEGER, James M.

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KRUEGER, James M.

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JAMES M KRUEGER’S RESEARCH INTERESTS My laboratory is concerned with the biochemical regulation of sleep. We described the somnogenic actions of many cytokines and showed that interleukin-1 (IL1) and tumor necrosis factor (TNF) are involved in physiological sleep regulation. Further we have an independent project demonstrating the involvement of growth hormone releasing hormone in sleep regulation. Each of these substances, mRNA and protein levels, vary in brain with the sleep-wake cycle and are affected by sleep deprivation. These substances increase non-rapid eye movement sleep (NREMS). Conversely, if they are inhibited, sleep is inhibited, and the sleep rebound after sleep deprivation is also blocked. Mice lacking IL1 or TNF receptors sleep less than normal, and animals under-expressing GHRH or the GHRH receptor in brain sleep less than normal. All of these substances act in the hypothalamus and other brain areas to promote NREMS. We have also examined many substances related to these somnogens with the goal of developing our knowledge of the biochemical network regulating sleep, e.g. we showed that the ghrelin/obestatin gene is involved in feeding-related sleep and metabolic responses. Our second interest deals with sleep and infectious diseases. Bacterial, protozoan, fungal and viral infectious agents greatly alter sleep. In the case of bacteria we worked out the molecular steps responsible. For example, with gram-positive bacteria, bacterial peptidoglycan (from cell walls) is digested by macrophages, releasing somnogenic muramyl peptides (these are the monomeric building blocks of bacterial cell walls). Muramyl peptides in turn induce enhanced production of cytokines which in turn affect sleep. Currently we are focusing our efforts on the mechanisms involved in influenza virus – induced sleep. In this case, viral double-stranded RNA, released from infected cells, seems responsible for initiating the sleep cascade. Very recently we showed that in mice challenged intranasally with influenza virus, the virus is found within hours in the olfactory bulb where it enhances brain production of cytokines. A third interest of my laboratory is with sleep function and brain organization as it applies to sleep. In short, we hypothesized that neuronal assemblies are the organizational level at which sleep is initiated and that local sleep at this level is dependent upon prior activity within the local network. Thus, we showed that extracellular ATP, released by active glia and neurons enhances expression of TNF and IL1 that in turn drive increases in NREMS locally. TNF expression by neurons is enhanced in the somatosensory cortex if afferent input induced by whisker twitching is increased. Further, individual cortical columns such as somatosensory barrels alternate between functional states, one of which is usually associated with organism sleep and that the sleep-like functional state is induced by TNF.

KRUEGER, James M.

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NF-BSleep and plasticity

regulatory substancesIL1, TNF, NGF, EGF

Neuronal

Assembly

Sleep

State

COX-2

NO

Adenosine

PGs

A1ARExcitatory

(glu)

&

Inhibitory

(GABA)

hours

gene transcription

and translation

seconds

blood flow

msec

synaptic

transmission

The Sleep Homeostat

NOS

Inhibitors (e.g.,

IL4,IL10,CRH,

sTNFR, sIL1R,

IL1RA

Cell electrical and

metabolic activity

Circadian

Clock

Cry l, 2

Per l, 2

BMAL

CLOCK

KRUEGER, James M.

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Potential References: WSU faculty Dave Rector, Professor [email protected] Jaak Panksepp, Professor [email protected] Greg Belenky, Professor [email protected] Yan Dong, Associate Professor [email protected] Sandip Roy, Associate Professor [email protected] Hans Van Dongen, Professor [email protected] Outside WSU in USA Charles Dinarello, U. Col. Med. School, Professor, [email protected] Gina Poe

*, U. Mich. Associate Professor [email protected]

Henk Granzier*, U. Arizona, Professor [email protected] Horacio de la Iglesia, U. Washington, Associate Professor [email protected] Mark Opp, U. Washington, Professor, [email protected] *Worked as faculty for me when I was chair. Outside WSU in Europe/Japan Axel Steiger, Professor Max Plank Institute for Psychiatry, Munich [email protected] Luca Imeri, Professor, University of Milan Medical Center [email protected] Tetsuya Kushikata, Professor Hirosaki Medical School [email protected] Medhi Tafti, Professor, Center for Integrative Genomics, Univ. Lausanne [email protected] V/Krueger/James REV: 9/1/2011 J; Spellck: 04/07/08 (B)

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JAMES M. KRUEGER WWAMI Medical Education Program … · CURRICULUM VITAE JAMES M. KRUEGER WWAMI Medical Education Program ... Rachida Roky, Ph.D. (1994) Sergei Novitsky, Ph.D., M.D.,