JAI activities toward development of accelerators for medicine€¦ · • [1] International (PCT) Patent Application No. PCT/GB2012/052632 (WO2013/061051) filed on the 26th October

JAI activities toward development of accelerators

for medicine

Workshop on Particle Accelerators for Medicine

Andrei Seryi

17 February 2015

accelerators for medicine, 17 Feb 2015, A. Seryi 2

1.  Laser plasma acceleration study for medicine in JAI/IC

2.  Hi-Flux resonant plasma/fiber laser as new imaging tool for medicine in JAI

3.  UH-FLUX coupled cavity X-ray/THz source as new versatile tool for medical and other applications

4.  Our activities with Gray Institute & PTCRI – (briefly, see talk by Claire Timlin)

Relevant activities presented in this talk

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1 – LP acceleration for medicine 1

Astra Gemini experimental Set-Up

Z.Najmudin, et al


Towards light sources

S. Kneip et al., Nature Physics 2010

Vulcan Petawatt25 keV

Hercules10 KeV

LBNL

2. G

ener

atio

n 3.

Gen

erat

ion

DAISY

ESRF

DAISY

LBNL

slicing bending magnet

slicing undulator

Doris 3 wiggler

8 3 VuV undulator

SOLEIL

DAISY

Petra 3 X-ray undulator ID9

U20

DAISY

bending magnet

other light sources from A. Rousse et al, EPJD, 2008

Betatron x-ray source shown to have comparable brightness to 3rd generation light source

S. Kneip et al., Applied Physics Letters 2011

small source size ideal for phase contrast imaging

Z.Najmudin, et al



1 Acceleration with Gemini to > GeV

Materials in prep for publications removed



Imaging with Gemini laser-plasma acceleration and betatron radiation

Z.Najmudin, et al

Small size of emitting area => use of phase contrast technique => many applications in medical imaging

Lopes N. et al. X-ray phase contrast imaging of biological specimens with femtosecond pulses of betatron radiation from a compact laser plasma wakefield accelerator. In Preparation (2014).

Bone tomography

Cole J. et al. X-ray phase contrast imaging of biological specimens with femtosecond pulses of betatron radiation from a compact laser plasma wakefield accelerator. Submitted (2014).

Materials in prep for publications removed



Ion/proton plasma acceleration

Z.Najmudin, et al

Progress of proton/ion plasma acceleration allow to foresee the timeliness and the need of our R&D towards: -- 10-20 MeV proton-plasma facility that will aim for development of this technology in bio/medical practice


–  Use a train of pulses separated by plasma period to resonantly excite wakefield

–  Energy stored efficiently in plasma wave –  Can tune pulse separation to avoid

saturation (unlike beat-wave scheme)

–  Fibre lasers can deliver kW mean powers at wall-plug efficiencies > 20%

–  Fibre lasers can generate short pulses with very high efficiency

S.Hooker, R.Bartolini, S.Mangles, A.Tünnermann, L.Corner, J.Limpert, A.Seryi, R.Walczak. Jan 30, 2014, J.Phys. B47 (2014) 234003

2 – Hi-Flux project (Multi-pulse LWFA ) 2


MP-LWFA: outline concept –  1D and 3D fluid simulations

show: •  Single pulse Eacc = 0.160 GV/m •  Gradient increases linearly up to

~ 60 pulses •  Max Eacc = 9.6 GV/m (~70 pulses) •  ΔW = 2.5 GeV in Ld = 265 mm •  Eacc rolls over due to loss of

resonance (relativistic mass increase)...

•  ... but this can be overcome by re-tuning pulse train

Simulations by Naren Ratan

Laser-plasma parameters E = 10 mJ / pulse τ = 100fs w0 = 20 µm a0 = 0.1 ne = 1.7 × 1017 cm-3

Controlled injection

JAI team, in collaboration with Jena (Germany)

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2 2 – Hi-Flux project - applications

The high rep-rate will allow Hi-FLUX accelerator to work as a high brightness X-ray source bringing to hospitals high quality imaging methods enabling early diagnosis of diseases such as cancer, which are available right now only for very small number of patients at synchrotrons such as ESRF or Elettra Hi-FLUX collaboration: Oxford (coordinating), ESRF, IC, Jena and UCL


•  Collaboration of UK centers JAI, CI, STFC is developing an advanced Compton/THz source –  This design will surpass any existing designs

•  [1] International (PCT) Patent Application No. PCT/GB2012/052632 (WO2013/061051) filed on the 26th October 2012

•  [2] Oxford University Isis Project No. 11330 – “Asymmetric superconducting RF structure” (UK Priority patent application 1420936.5 titled ‘Asymmetric superconducting RF structure’ filed on the 25th November 2014

R. Ainswortha, S. Boogertd, G. Burtb, L. Cornera, S. Jamisonc, P. Karataevd, I.V. Konopleva, A. Lyapind, P. Mcintoshc, B. Militsync, S. Pattalwarb, A. Seryia, and A.Wheelhousec a/ JAI, University of Oxford, b/ CI, Lancaster University, c/ ASTeC, STFC d/ JAI, Royal Holloway, UK

Next steps in Compton/THz sources – UH-FLUX project

3 – UH-FlUX project 3


UH-FLUX – conceptual layout 3

Schematics removed


UH-FLUX Decoupling all modes except the accelerating mode to

maximize the beam current

Acc. mode One of transverse modes

UK Priority patent application 1420936.5 filed on the 25th November 2014

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UH-FLUX – conceptual layout 3

Generation of radiation: Compton or Coherent Smith-Purcell (THz) or other method

Schematics removed


UH-FLUX – radiation generation

Compton Coherent Smith-Purcell

We are studying the range of possible applications of UH-FLUX technology, including medical direction

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Schematics removed


4 – JAI-PTCRI-Gray Inst. 4


4 4 – JAI-PTCRI-Gray Inst.

•  JAI will be engaged into activities toward –  Precision Cancer Medicine Institute

•  The efforts are highly collaborative –  Via PTCRI and directly –  Working with Oxford Institute for Radiation Oncology (Gray

Inst.) –  Working with ProNova on present technology as needed and

focusing on technologies of the future (ion plasma acceleration)

–  Working in close collaboration with IC/(HEP and other departments) with CI, and with many other partners

(see talk by Claire Timlin for details of Precision Cancer Medicine Inst., ProNova, etc.)


1.  Laser plasma acceleration study -- new imaging and therapy tool for medicine

2.  Hi-Flux resonant plasma/fiber laser -- new imaging tool for medicine

3.  UH-FLUX coupled cavity X-ray/THz source -- new versatile tool for medical and other applications

4.  Our activities with Gray Institute & PTCRI -- direction of strong collaborative efforts

Summary

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Documents

JAI activities toward development of accelerators for medicine€¦ · • [1] International (PCT) Patent Application No. PCT/GB2012/052632 (WO2013/061051) filed on the 26th October