Articles with related stories in the IN THIS ISSUE section have page numbers in RED.

On the coverHyperoxidation and oligomerization of PrxII (green) halts cell cycle progression when H2O2 levels are high.See page 779.

NEWSIn This Issue676 • BRCA1 in replication

• Peroxide detection system

• Promoting ESCRT-I narcissism

• Do-it-yourself insertion

• Damage stops bud growthN. LeBrasseur

Research Roundup678 • Gellular transport

• Fever brings in the lymphocytes

• Synaptic vesicle structure

• Lymphocyte tracks

• Moving cells link membrane and actinW.A. Wells

REVIEWSMini-Reviews681 The depletion attraction: an underappreciated force driving

cellular organizationDavide Marenduzzo, Kieran Finan, and Peter R. Cook

687 Cracking up: symmetry breaking in cellular systemsEwa Paluch, Jasper van der Gucht, and Cécile Sykes

RESEARCH ARTICLESReports693 BRCA1 foci in normal S-phase nuclei are linked to interphase

centromeres and replication of pericentric heterochromatinGayle J. Pageau and Jeanne B. Lawrence

703 Human SHPRH suppresses genomic instability through proliferating cell nuclear antigen polyubiquitinationAkira Motegi, Raman Sood, Helen Moinova, Sanford D. Markowitz, Pu Paul Liu, and Kyungjae Myung

709 Requirement of biphasic calcium release from the endoplasmic reticulum for Fas-mediated apoptosisAnn L. Wozniak, Xinmin Wang, Emily S. Stieren, Shelby G. Scarbrough, Cornelis J. Elferink, and Darren Boehning

715 Did2 coordinates Vps4-mediated dissociation of ESCRT-III from endosomesDaniel P. Nickerson, Matthew West, and Greg Odorizzi

721 Inhibition of Rho A activity causes pemphigus skin blisteringJens Waschke, Volker Spindler, Paola Bruggeman, Detlef Zillikens, Gudula Schmidt, and Detlev Drenckhahn

VOL. 175, NO. 5, DECEMBER 4, 2006

JCB THE JOURNAL OF CELL BIOLOGY

on May 6, 2018jcb.rupress.org Downloaded from http://doi.org/Published Online: 4 December, 2006 | Supp Info:

Loss of Did2 blocks ESCRT-III release and thus prevents cargo sorting into MVBs. Vesicle budding still occurs, however, producing vesicular tubular endosomes.See page 715.

Articles729 Checkpoint proteins control morphogenetic events during DNA

replication stress in Saccharomyces cerevisiaeJorrit M. Enserink, Marcus B. Smolka, Huilin Zhou, and Richard D. Kolodner

743 An FHA domain–mediated protein interaction network of Rad53 reveals its role in polarized cell growthMarcus B. Smolka, Sheng-hong Chen, Paul S. Maddox, Jorrit M. Enserink, Claudio P. Albuquerque, Xiao X. Wei, Arshad Desai, Richard D. Kolodner, and Huilin Zhou

755 Phosphoregulation of Cbk1 is critical for RAM network control of transcription and morphogenesisJaclyn M. Jansen, Margaret F. Barry, Charles K. Yoo, and Eric L. Weiss

767 Unassisted translocation of large polypeptide domains across phospholipid bilayersSilvia Brambillasca, Monica Yabal, Marja Makarow, and Nica Borgese

779 Oxidation state governs structural transitions in peroxiredoxin II that correlate with cell cycle arrest and recoveryTimothy J. Phalen, Kelly Weirather, Paula B. Deming, Vikas Anathy, Alan K. Howe, Albert van der Vliet, Thomas J. Jönsson, Leslie B. Poole, and Nicholas H. Heintz

791 Wnt11 controls cell contact persistence by local accumulation of Frizzled 7 at the plasma membraneSabine Witzel, Vitaly Zimyanin, Filipa Carreira-Barbosa, Masazumi Tada, and Carl-Philipp Heisenberg

803 EPI64 regulates microvillar subdomains and structureAbraham Hanono, Damien Garbett, David Reczek, David N. Chambers, and Anthony Bretscher

815 New component of ESCRT-I regulates endosomal sorting complex assemblyTony Chu, Ji Sun, Suraj Saksena, and Scott D. Emr

825 A conserved late endosome–targeting signal required for Doa4 deubiquitylating enzyme functionAlexander Amerik, Nazia Sindhi, and Mark Hochstrasser

837 Correction