IX Meeting Stem Cell Research Italy

21 – 23 giugno 2018

Aula Magna, Università degli Studi di Milano

Via Festa del Perdono, 7

Ble & Associates srl id. 5357 Numero ecm 230946, edizione 1 Responsabile scientifico: prof. Umberto Galderisi, prof. Yvan Torrente Destinatari dell’attività formativa: tecnico sanitario laboratorio biomedico; tecnico della fisiopatologia cardiocircolatoria e perfusione cardiovascolare; ostetrica/o; infermiere pediatrico; infermiere; igienista dentale; fisioterapista; dietista; assistente sanitario; fisico; odontoiatra; veterinario; farmacista; biologo; chimico; medico chirurgo Obiettivi formativi e area formativa: linee giuda – protocolli e procedure Orario di inizio e di fine: 21 giugno ore 14:15/18:00 - 22 giugno ore 08:30/16:00 23 giugno 08:45/13:00 Ore formative: 10 ore Numero dei crediti assegnati: 10

21 GIUGNO

14.15 Attendee registration

14.45 WELCOME CEREMONY

Umberto Galderisi and Yvan Torrente

NEW HORIZONS FOR STEM CELL RESEARCH: IPS, EXTRACELLULAR VESICLES AND

BEYOND

Chair: Augusto Pessina

KEY LECTURE

15.00 Maurilio Sampaolesi

miRNAs, exosomes and iPS cell technologies

15.45 Dario Siniscalco

Possible use of stem cells in autism spectrum disorders: scientific rationale

16.15 Anna Lange Consiglio

Anti-inflammatory and immunomodulatory miRNA cargo of microvesicles obtained from equine

amniotic progenitor cells in different time-span of in vitro culture

16.45 Coffee break

PAOLO BIANCO AWARD

Chair: Assunta Pandolfi and Letizia Penolazzi

17.15 Three selected communications by young investigators

18.00 Concluding remarks

22 GIUGNO

08.30 Attendee registration and poster set-up

STEM CELLS IN NEUROMUSCULAR AND CARDIAC DISEASES

Chairs: Marco Marchisio - Domitilla Mandatori

09.00 Davide Gabellini

Molecular pathogenesis of FSHD muscular dystrophy

09.30 Sveva Bollini

Paracrine boosting of endogenous mechanisms of cardiac regeneration

10.00 Massimiliano Gnecchi

Induced pluripotent stem cells technology: toward precision medicine in cardiology

10.30 Coffee break

POSTER SESSION

Chairs: Yvan Torrente and Roberta Piva

11.00 Guided Poster Tour (5 minutes presentation)

12.00 SCR Assembly

13.00 Light lunch

FROM BASIC TO APPLIED RESEARCH IN STEM CELL FIELD: AN UPDATE

Chair: Roberta Piva and Tiziana Squillaro

14.00 Lorenza Lazzari

Can we distinguish fetal, adult and iPS-derived MSCs?

14.30 Margherita Maioli

Unfolding the stem cell world: a path among the use of molecules and physical energies

15.00 Gianvito Martino

Therapeutic plasticity of neural stem cells

15.30 Two Oral Communications By Young Investigators

Chair: Mario Romano and Elisabetta Lambertini

16.00 Concluding remarks

23 GIUGNO

08.45 Attendee registration

09.00 Two Oral Communications By Young Investigators

Chair: Mario Romano and Elisabetta Lambertini

NEURAL STEM CELLS AND THEIR CLINICAL APPLICATION

Chairs: Gina Lisignoli – Nicola Alessio

09.30 Luciano Conti

In vitro modelling of human neocortical development using pluripotent stem cells

10.00 Maurizio Gelati

Human neural stem cells production for neurodegenerative diseases treatment

10.30 Letizia Mazzini

Foetal neural stem cell transplantation in amyotrophic lateral sclerosis: long-term follow-up of a

phase 1 clinica trial

11.00 Coffee break

11.30 THREE SELECTED POSTER COMMUNICATIONS BY YOUNG INVESTIGATORS

Chair: Giovanni Di Bernardo and Yvan Torrente

12.30 evaluation of ecm credits

13.00 Concluding remarks and light lunch

The achievement of novel findings in stem cell research will be the subject of the meeting. Stem cell therapy represents great promise for the future of molecular and regenerative medicine. The use of several types of stem cells is a real opportunity to provide a valid approach to curing several untreatable human diseases. Before it is suitable for clinical applications, stem cell biology needs to be investigated further and in greater detail. Basic stem cell research could provide exact knowledge regarding stem cell action mechanisms, and pre-clinical research on stem cells on an in vivo model of disease provides scientific evidence for future human applications. Applied stem cell research is a promising new approach to handling several diseases

CURRICULUM DAVIDE GABELLINI

RESEARCH INTERESTS

Investigation of the role of epigenetic regulation of gene expression in normal muscle biology and in muscular

dystrophy using facioscapulohumeral muscular dystrophy (FSHD) as a paradigm. Cellular and animal models of FSHD

are used to elucidate the pathways altered in the disease and to develop and test possible therapeutic approaches.

FORMAL EDUCATION

PhD 2000. Genetic Sciences University of Pavia, Italy

Undergraduate 1992. Full marks and honors (110/110, cum laude) Biological Sciences University of

Pavia, Italy

ADDITIONAL COURSES

"Theoretical and Practical Course on Yeast Molecular Genetics", at the International Centre for Genetic Engineering

and Biotechnology (ICGEB), Trieste - (Italy). Sep. 1995.

"Molecular and Cellular Approaches to Genetic Analysis of Development", Intensive Erasmus Course at Ecole Normale

Superieure, Université Paris 7, Paris. Sep. 1997.

HONORS AND OTHER SPECIAL RECOGNITIONS

2017- Director, Interuniversitary Institute of Myology

2012-2016 Epigenetics and Systems Biology Network of Excellence (EpiGeneSys)

2008-2013 European Research Council Starting Grant

2006-2016 Dulbecco Telethon Institute Carrier Award

2006-2009 European Alternative Splicing Network of Excellence (EURASNET)

2006-2008 Marie Curie International Reintegration Grant

RESEARCH EMPLOYMENT

2014- Head of Unit, Division of Regenerative Medicine, San Raffaele Scientific Institute, Milano, Italy

2013-2016 Senior DTI Scientist, San Raffaele Scientific Institute, Milano, Italy

2008-2014 Senior Researcher, Division of Regenerative Medicine, San Raffaele Scientific Institute, Milano, Italy

2006-2013 Assistant DTI Scientist, San Raffaele Scientific Institute, Milano, Italy

2000-2006 Postdoc, HHMI, Program in Gene Function and Expression, University of Massachusetts Medical

School, Worcester, USA

1996-2000 PhD Candidate, University of Pavia, Italy

SAN RAFFAELE SCIENTIFIC INSTITUTE (OSR) COMMITTEES

2015- OSR Commission for Appointments and Promotions (CAP)

2006- Office of Graduate Studies, UniSR-Open University Cellular and Molecular Biology International PhD

Program

DULBECCO TELETHON INSTITUTE COMMITTEES

2010- DTI Scientists National Representative

TEACHING EXPERIENCE

2006- Member of the Office of Graduate Studies, International PhD Program in Cellular and Molecular

Biology, University Vita-Salute San Raffaele, Milano, Italy and the Open University, London, UK.

2007- Lecturer University Vita-Salute San Raffaele, Milano, Italy

2007- Lecturer Institute for Advanced Studies of Pavia, Italy

PATENTS

Methods of Detecting and Treating Facioscapulohumeral Muscular Dystrophy, U. S. num 10/686,491

Anna Lange Consiglio

CURRICULUM VITAE

INFORMAZIONI PERSONALI

COGNOME LANGE CONSIGLIO

NOME ANNA

DATA DI NASCITA 03, LUGLIO, 1962

Cittadinanza Italiana

Posizione attuale Categoria EP, posizione economica EP3 - Area Tecnica, Tecnico-Scientifica ed

Elaborazione Dati, e responsabile del laboratorio di Riproduzione del Centro presso il

Centro Clinico-Veterinario e Zootecnico-Sperimentale di Ateneo (Facoltà di Medicina

Veterinaria), Università degli Studi di Milano

Indirizzo lavorativo Centro Clinico-Veterinario e Zootecnico-Sperimentale di Ateneo

Sezione di Riproduzione

Università degli Studi di Milano

Località Polledra

Via dell’Università,6

26900 Lodi

E-mail: anna.langeconsiglio@unimi.it

Titoli di studio

1981 Diploma di Perito Agrario conseguito presso l’Istituto Tecnico Agrario “G. Raineri” di Piacenza con

voti 60/60

1986 Diploma di Laurea in Scienze della Produzione Animale, Università degli Studi di Milano, con voti

110/110 e lode al termine del quarto anno del corso di laurea poiché l’immatricolazione è avvenuta

nell’anno accademico 1982/1983

Carriera Professionale

1986 Tecnico Coadiutore presso l’Istituto di Anatomia degli Animali Domestici con Istologia ed Embriologia

dopo superamento di concorso pubblico per titoli ed esami

1989 Funzionario Tecnico dell’area Funzionale Tecnico Scientifica e Socio Sanitaria, per riconoscimento

mansioni dopo giudizio di idoneità, ai sensi dell’art.1 della legge 21.12.1989 n° 63

2002 Vincitrice del concorso riservato, per titoli ed esami, a n. 1 posto di categoria EP posizione economica

EP1 - Area Tecnica, Tecnico-Scientifica ed Elaborazione Dati, presso l’Istituto di Anatomia degli Animali

Domestici con Istologia ed Embriologia della Facoltà di Medicina Veterinaria dell’Università degli Studi

di Milano, ai sensi dell’art.57 del C.C.N.L.

2005 Vincitrice di un posto di dottorato di ricerca senza borsa di studio, presso il Dip artimento di

Alimentazione Animale e Sicurezza Alimentare dell’Università degli Studi di Milano.

2005 Responsabile del laboratorio della Sezione di Riproduzione dell’Ospedale Grandi

Animali di Lodi nella qualifica di EP3

2008 Dottore di ricerca

2011 Nomina a cultore della materia per il corso di Patologia della riproduzione animale. Modulo: Patologia

della riproduzione e fecondazione artificiale

Lodi, 13 Febbraio 2018

CURRICULUM GIANVITO MARTINO

Gianvito Martino received his Medical Degree in 1987 from the University of Pavia (Italy) where he

completed his residency in Neurology in 1991. In 1990, he was a Visiting Scientist at the Department of

Neurology of the Karolinska Institute (Stockholm, Sweden) and, from 1991 to 1992, he held the position of

Research Associate at the Department of Neurology of the University of Chicago (Chicago, IL, USA). From

1992 to 2008, he worked first as Senior Scientist and then as Director of the Neuroimmunology Unit of the

San Raffaele Scientific Institute in Milan (Italy) where, from 2008 to 2016, he acts as Director of the Division

of Neuroscience. From 2016, he has been appointed as Scientific Director of the San Raffaele Scientific

Institute. He is full professor of Experimental Biology at the San Raffaele Vita-Salute University in Milan

and, from 2009 to 2017, he was appointed Honorary Professor at Queen Mary University of London. He

has been the Scientific Secretary (from 1998 to 2003) and the President (from 2009 to 2012) of the Italian

Neuroimmunology Society (AINI). He is the founder and the Scientific Coordinator of the European School

of Neuroimmunology (ESNI) and of the Global Schools of Neuroimmunology (GSNI). Within the

International Society for Neuroimmunology (ISNI), he served as advisory board member (from 2002 to

2010), Vice President (from 2010 to 2012) and President (from 201 to 2014). He has been a member of the

scientific committee of the European Committee for Treatment and Research in Multiple Sclerosis

(ECTRIMS), the Italian Multiple Sclerosis Foundation (FISM), and the Multiple Sclerosis International

Federation (MSIF). He served as member of the Grant Reviewing Panel of the UK Multiple Sclerosis Society

from 2007 to 2015 and, from 2012 to 2016, he served as a member of the Wellcome Trust's Peer Review

College. From 2015 he serves as Panel Member of the European Research Council (ERC). He is co-author of

more than 250 original articles and book chapters. His scientific interests range from the elucidation of the

pathogenic mechanisms of immune-mediated central nervous system disorders to the development of

gene and stem cell-based therapies for the treatment of these disorders.

Alessandra

Evidenziato