Israeli Digital Health Roadsho · revolutionizing digital early detection, diagnosis and monitoring ... DALI focuses on the development of drug delivery technologies from product

Hong Kong | 27 June 2019 (Thursday)

Israeli Digital Health Roadshow

Companies

Alango Technologies – Wear & Hear 6

BSP Medical Ltd 7

DALI Medical Devices Ltd 8

DigiSense 9

HealthWatch Ltd 10

iFeel Healthy 11

Melcap Systems Ltd 12

MyOr Diagnostics 13

Wearable Devices Ltd 14

Israel Innovation AuthorityThe Israel Innovation Authority, responsible for the country’s innovation policy, is an independent and impartial public entity that operates for the benefit of the Israeli innovation ecosystem and Israeli economy as a whole Its role is to nurture and develop Israeli innovation resources, while creating and strengthening the infrastructure and framework needed to support the entire knowledge industry

Israel Innovation Authority advises the government regarding innovation policy, monitors and analyzes the dynamic changes taking place throughout the innovation environments and creates cooperation with counterpart agencies to promote technological innovations in the Israeli industry and economy

The Israel Innovation Authority provides a variety of practical tools and funding platforms aimed at addressing the dynamic and changing needs of the local and international innovation ecosystems Australia and Israel have signed 3 different R&D agreements – with NSW, Victoria and with the federal government The programs activated under agreements aims to facilitate, support and encourage partnerships between Australian and Israeli companies

Mrs. Racheli Ben-onn

China, Hong-Kong & Taiwan Collaboration Manager International Collaboration Division Israel Innovation Authority Email: rachelibo@innovationisrael org il Website: https://innovationisrael org il/en/

Contact Details

Economic and Trade Mission of the Consulate General of Israel in Hong KongThe Israel Economic and Trade Missions worldwide, under the Ministry of Economy and Industry of the Israeli Government, are responsible for promoting export from Israel and investment opportunities between Israel and targeted countries The team based in Hong Kong is covering the regions Hong Kong and Macau

Through organizing and supporting a wide range of business activities and services such as exhibitions, seminars and inbound and outbound delegations, the Israel Economic and Trade Missions are committed to provide quality services that matches and connects the business communities and organizations of both ends

Mrs. Ester Perets Burke

Consul, Head of Economic and Trade Mission Consulate General of Israel in Hong Kong & Macau Email: Ester Burke@israeltrade gov il

Contact Details

Ms. Winkie Lui

Chief Economic and Trade Officer Consulate General of Israel in Hong Kong & Macau Email: winkie lui@israeltrade gov il Tel : 852-2821-7509

6

Alango Technologies – Wear & Hear

Industry Sector: Digital Health

Website: www wearandhear com

Company Description:

The Alango "Wear & Hear" division was founded to create a new category of products that would provide a solution for hundreds of millions of hearing-impaired people worldwide Today it offers a line of self-programmed, affordable, personal hearing devices These solutions help people with mild to moderate hearing loss to improve their quality of life in different situations

The Wear & Hear product line is based on Alango Technologies' two decades of successful experience developing and licensing voice and audio enhancement technologies for a variety of applications Tens of millions of communication products worldwide integrate Alango algorithms and software, helping users to enjoy clear audio and clean voice communication Now hearing-impaired people can benefit from it as well

Technology Description:

People who experience mild to moderate hearing loss will appreciate the Wear & Hear line of assistive hearing solutions, which amplify and clarify important sounds based on the wearer’s preferences Combining the functionality of a digital hearing aid and a Bluetooth headset, these products are stylish, affordable, and versatile, delivering high performance and advanced functionality

The Wear & Hear line includes:• Binaural BeHear NOW headset for middle-aged, active people• Monaural BeHear BUSINESS for people in service industries which require live conversations with customers• Binaural BeHear ACCESS with large controls for seniors or those with dexterity issues

All Wear & Hear products integrate digital hearing enhancement technologies developed by Alango, such as multi-channel dynamic range processing, advanced acoustic feedback reduction, and noise reduction Some of the technologies, such as EasyListen™ for slowing down incoming speech during mobile phone conversations, and ListenThrough™ which keeps the user aware of the environment while listening to music, are truly unique

Wear & Hear products come with a free smartphone application for iOS and Android The application includes a simple, self-administered hearing assessment After performing the assessment, all sounds become customized for the specific user The application also allows the user to fine-tune hearing in real-time

Looking for:

business partners/ Distributors

Product Stage: Sales

Name: Yuval Arbel

Position: International Sales & Business Development

Email: [email protected]

7

BSP Medical Ltd.

Industry Sector: Digital Medical Health Care

Website: www BSPmedical com


BSP Medical is a ground-breaking digital health-tech company that developed the HyperQ technology, a suite of electrocardiogram, ECG, algorithms implemented in software, revolutionizing digital early detection, diagnosis and monitoring of cardiac disease

Meeting the major challenges of the healthcare digital era, BSP Medical provides in-depth and unique clinical value, bringing a new dimension into ECG clinical diagnosis and monitoring HyperQ creates a product platform for any clinical venue and to the emerging wellness market HyperQ marks a revolution in cardiac decision making


HyperQ technology is a suite of algorithms implemented in software, aimed at the early detection of coronary artery disease (CAD) and cardiac conditions HyperQ™ can be applied in any venue and on any monitoring or diagnostic platform such as standard rest and stress ECG devices or wearables devices

HyperQ demonstrated to have a unique predictive value for Major Adverse Cardiac Events (MACE) HyperQ earlier detects acute coronary artery disease on any resting ECG system Provides a new perspective to the clinical staff, including diagnosis of Non-ST Elevation MI (NSTEMI) and Unstable Angina (UA) Providing an innovative non-invasive and highly reliable solutions for the diagnosis and monitoring of Ischemic Heart Disease (IHD) and Acute Coronary Syndrome (ACS)

HyperQ™ is a proprietary and patented technology It analyses the high-frequency QRS depolarization segment of the cardiac cycle, whereas conventional ECG analysis of the ST segment is related to the repolarization phase of the cycle HyperQ™ provides superior clinical accuracy to any other non-invasive solution currently available HyperQ analyses ECG data and issues a clinical report It can be installed on the cloud, as a stand-alone module on a PC or be integrated in an ECG system

The American Heart Association (AHA) pointed out that High-Frequency QRS indicators, measured by HyperQ, have been found to have useful test performance for detection of CAD HyperQ is FDA cleared and CE marked

Looking for:

Digital health care partners, Business Partners, Distributors, Customers, Clinical partner, Complementary wearable medical/wellness technology, hardware ECG manufactures, Investors

Round Investment stage: C

Product Stage: Initial Sales

Name: Dr Mario Olszakier

Position: CEO


8

Medical Devices

DALI Medical Devices Ltd.

Industry Sector: Medical devices, drug delivery devices, digital health

Website: www dalimed com


DALI focuses on the development of drug delivery technologies from product concept to commercialization Active in the drug delivery arena for over 20 years

One of the autoinjectors DALI invented and developed was launched in the market by a Top 10 pharma company with a blockbuster biologic


Synnect™ Connectivity Platform

When close monitoring of injected medications is required, the Synnect platform provides injection information via a smartphone app that uploads real-time data to the cloud to benefit patient treatment and health, pharma and CRO companies that conduct clinical trials where injection information is critical to the success of multimillion-dollar drugs, and payers that require adherence data to track that patients are actually injecting high-cost medications

Synnect monitors the injection process of any standard or safety syringe by tracking injection date and time, injection start and completion, and injected volume – all in real time Data is transmitted wirelessly through a smartphone app to a secure location in the cloud for relevant stakeholders

DALI’s Synnect connectivity platform can be integrated with DALI’s SAN™ product line, prefilled and safety syringes, and other pens and autoinjectors

* International patents pending

Other products and technologies: SAN™ – Safe Auto-Needle product line, autoinjectors, Pens

Looking for:

Strategic Investment/Financial investment/business partners

Round Investment stage: A

Product Stage: Synnect™ is in prototype stage ; some SAN products are in R&D or commercial stage

Name: David Daily

Position: CEO & Co-Founder


9

DigiSense

Industry Sector: Digital health care

Website: www dg-sense com


DigiSense is a market leader in contact-free wearable monitoring technology, SHWMD (Smart HealthWearable Monitoring Device) data-point with IoT capabilities The IoT enables DigiSense to convert any type of diaper to a next gen interactive diaper that collects data through a device superficially attached to the exterior layer of the diaper, then transfer the data to the end user remotely, in real time 24/7

It monitors and alerts for: Urine flow, Urine hue, Bowel movement, Flatulence, Bedsores, Falling, Ambient temperature, Respiratory rate, Sleeping quality and motion


DigiSense has developed a variety of methods and different technology applications that are covered by 6 separate patents 1st generation device is using spectrum analysis through any type of woven or non-woven material, with no limitation to the fabric color, such as diapers, pants, sanitary pads and more

It is the only patentable and accurate technology for non-invasive diagnostic today DigiSense is also developing based on the current patents, the next diaper sensing generation, which covers full health/medical diagnostics capabilities like: Leukocytes, Nitrite, Urobilinogen, Protein, pH, Haemoglobin, Specific gravity

This technology along with its current technology will position DigiSense as a world pioneer in the evolve smart diaper industry

Looking for:

Strategic Investment/Financial investment/Business partners/Distributors/Integrators


Product Stage: Prototype

Name: Eyall Abir

Position: Founder & CTO


10

HealthWatch Ltd.

Industry Sector: Medical Devices; Digital Health; Wearable Devices; Smart Textile

Website: www healthwatchtech com


HealthWatch is a pioneer in harnessing textile technology to produce fashionable, smart-digital garments with interwoven sensors unobtrusively measuring vital signs of hospital-grade quality Its initial goal is dramatically reducing mortality and damages of no 1 killer: the heart

The company is led by highly experienced managers in the international medical devices market, and its Scientific Board is led by a Nobel Prize Laureate Among the current investors are Israeli, American and Chinese investors, public companies and private

HealthWatch has started its sales in 2019, and it is in an investment round process, to expedite sales and increase its leadership position worldwide


The unique technology of HealthWatch is its Smart Garment, with embedded textile sensors, in medical-grade quality, the first ever to receive FDA clearance as a Medical Device, for daily routine use When coupled with the monitor device attached to the garment, users get personal alerts and 24x7 assistance from remote medical experts without affecting lifestyle

The MasterCaution® platform provides 12-15 lead ECG, body temperature and motion information, with suspected event alerts for arrhythmia and ischemia, as well as falls and no motion With FDA 510(k) and CE Clearances, and CFDA in process, the company provides the only full ECG continuous monitoring available, for Home-care, Hospitals and clinics It is positioned in the center of the most attractive and growing market of medical-grade wearable devices, a $35B direct market potential, with its disruptive unique "Dressable" solutions

The strong IP and patents are in the area of embedded textile sensors, stretchable, washable and comfortable, as an integral part of "smart" underwear and T-shirts

Looking for:

Strategic Investment/Financial investment/business partners

Round Investment stage: B


Name: Dr. Yoram Romem

Position: Chairman


11

iFeel Healthy


Website: www iFeelLabs com www ichoiceRelax com


iFeel Specializes in Digital Therapy for Relaxation and Stress-Related Illness: High Blood Pressure, Sleep Disorders, Diabetes, and Asthma


iFeel develops technology-assisted guided breathing for relaxation The solution combines iFeel's world-leading medical relaxation app with a smart pulse oximeter

The innovative technology is based on a patented heart rate based algorithm which analyze the autonomic nervous system and provide breathing guidance to reduce stress related illness

The retail solution is branded ichoiceRelax (www ichoiceRelax com) and sales in pharmacies diagnostic and yoga/relaxation sections

ichoiceRelax brings a new opportunity to expand oximeter sales beyond COPD to stress-related illness: high blood pressure, sleep disorders, diabetes, asthma and more

Looking for:

Strategic Investment/Financial investment/business partners/ Distributors/ Hospitals


Product Stage: Sales

Name: Elad Fein

Position: CEO


12

Melcap Systems Ltd

Industry Sector: Digital Health/Medical Devices

Website: www melcap-systems com


Melcap Systems is an Israeli digital health startup, developed a novel, patented, cost-effective, wireless ingestible capsule system for the treatment of Obesity and Overweight Melcap has already launched its First-in-Human clinical study in an Israeli Hospital

The targeted market has a Huge volume: $250B annually The Company developed First truly affordable, AI-based weight loss patented system, which combined therapy and behavioral psychology approach Melcap system could be used both by Overweight and Obese individuals


The technology is based on the proven and proprietary advanced mode of action which is based on the medical paradigm of the neuromodulation or pulsed electrical stimulation on vagus nerve which could induce multiple physiologic functions related to food intake, energy metabolism, and glycemic control, which can result in appreciable weight loss

The system comprises three main parts: a disposable ingestible capsule, reusable wearable chest band or a wristband and a mobile app, installed on the user smartphone The ingestible capsule, which is taken every 2 days, combines miniature electronic circuitry with a microcontroller, antennae, power source and electrodes, all hermetically sealed in the plastic body

Looking for:

Strategic Investment/Financial investment/business partners/ Hospitals



Name: Dr. Alex Melamud

Position: CEO


13

MyOr Diagnostics


Website: www myor me


MYOR is a Digital Health company developing cutting-edge technologies for disease prevention and health management Via skin-surface noninvasive monitoring of various biomarkers such as the microbiome, biophysical properties, optical properties, metabolites and volatiles combined with artificial intelligence and machine-learning, we personalize intervention for several health issues

Our lead product line is "Precision Infant Care", a product pipeline comprising of an AI algorithm that uses MyOr's skin measurement and self-reported data to predict the development of pediatric atopic dermatitis (eczema), food allergies & asthma and a topical solution to prevent its development for high-risk individuals MyOr has two more market-ready product lines: "Personalized Pediatric Nutrition“ ensuring proper iron levels in infants and toddlers to support healthy development "Personalized Diabetic Foods "management of diet in diabetics to reduce diabetic complications

We know that your skin reflects your health and is a window into your body By visualizing the skin, we can generate a personalized recommendation and make your body healthier


Atopic dermatitis, also known as atopic eczema, is a dermatological condition accompanied by skin inflammation Symptoms include itching, red, swollen, and/or cracked skin, indirect symptoms include wounds, infections and loss of sleep (developmental delays) In addition, children with atopic dermatitis are at high risk for other conditions, including food allergies, hay fever and asthma It is a wide-spread condition which affects over 15% of infants and its incidence has increased significantly over last years Current approaches are strictly limited to treating the disease and include topical steroids, antihistamines and UV light therapy MyOr is the first to predict and prevent the disease, thereby improving the child's health and preventing unnecessary pain and expenses for years to come

The prediction is done by advance analytics algorithm which gathers information from a digital survey on the infant, its family and environment and a CE-approved medical device which measures the integrity of the skin barrier in a pain-free and non-invasive 30-second procedure For individuals assessed to be high-risk, MyOr has developed a topical solution that integrates a natural functional ingredient with the ability to strengthen the skin barrier It ensures microbiome diversity and significantly reduces the chances of developing atopic dermatitis

Looking for:

Strategic Investment/Financial investment/business partners/ Distributors/ Integrators/ Hospitals

Round Investment stage: B


Name: Idan Katz

Position: CEO


14

Wearable Devices Ltd.

Industry Sector: Wearables / Sensors

Website: www getmudra com


Wearable Devices develops a unique non-invasive wearable device which uses electrodes to decode the neural activity of the nervous system that control the hand and finger movement Our cutting-edge technology includes miniaturized electronics combined with real time AI, deep learning and neural networks, running on mobile, and cross-platforms

This technology is most useful for stroke rehabilitation, prosthetic control, learning disability monitoring, epileptic seizure alert, gesture detection health Our Device offers a new type of bio-potential signal which will become as common as ECG, EEG and EMG for digital health We are looking for strategic partnership to whom we offer a software and hardware license to integrate our technology into their current and future products and services Visit our website at www wearabledevices co il to learn more


Mudra is a wrist-worn Brain Device Interface, available now at www getmudra com The device contains Electrodes, proprietary Surface Nerve Conduction (SNC) sensors, compute unit, IMU, battery and Bluetooth connectivity

The human wrist is a highly valuable "real-estate" for sensing the human body Nerve bundles and arteries pass directly beneath the skin thus it is possible to sense the electrical conductance of the nerves and other bodily functions and collect valuable data

When the user moves his fingers, the SNC sensors detect biometric signals originating from the nervous system passing through the wrist Deep learning algorithms translate electronic signals and classify them as a user-intended finger movement The signal data streams are used for analytics and control purposes, such as understanding which finger the user intended to move, and what the fingers are doing

Looking for:

Strategic Investment/Financial investment / Hospitals



Name: Shmuel Barel

Position: VP Marketing & Business Development


Documents

Israeli Digital Health Roadsho · revolutionizing digital early detection, diagnosis and monitoring ... DALI focuses on the development of drug delivery technologies from product