Isobionics

Innovative creators of flavour and fragrances

The flavour Valencene is derived from orange

1 kg Valencene for 500.000 cans

Inefficient: 160.000 Oranges for 1 kg Valencene Harvest dependent

Taste Volume Price

Citrus greening disease in Florida 10-20% production loss

Isobionics solution: Common fermentation methods to transform sugar into Valencene

Fermentation

Distillation

Glucose

Proprietary fermentation technology (Similar to brewing beer)

Renewable & low cost materials

Sustainable and environmentally friendly Footprint only 1% of the agricultural surface needed Renewable materials

F&F is a strong growing market with a CARG of 5-6%. Total market value of $25 billion

• Valencene 80 (>80%)

Highest purity Valencene in the market

• Valencene 75 (>75%)

High purity Valencene with organoleptic

quality similar to Orange-derived product

Isobionics is the first company in the world that has succeeded in bringing a natural flavor, “Valencene(80) Pure ™”, based on a proprietary fermentation process to the market

• Nootkatone 80 (>80%) Nootkatone with organoleptic quality similar to

grapefruit-derived product

• Nootkatone 95 (95%) Nootkatone in compliance with EU legislation

• Nootkatone 98 (98%) Nootkatone for fragrance applications

• Nootkatone 70 (>70%) Nootkatone with with organoleptic quality similar to

grapefruit-derived product

• Beta Elemene Pure™ (98%) High purity Beta Elemene as a new building block

The John D. Walsh Company

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Food & nutraceuticals Vitamins

Carotenoids

Flavors & fragrances Aroma ingredients

Cosmetics Coenzyme Q10

Chrysantemic acid

Pyrethroids

Pharmaceutical ingredients

Diesel & Jet fuel

Farnesene

Fuels

Bio-Isoprene

Agrochemicals

Polymers

Taxol derivatives

Steroids

Anti-cancer

Platform technology for large markets

menthol

nootkatone limonene

valencene

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Only working double pathway in the world

Strong FTO and IP position Only patented double pathway isoprenoid strain in the world Strain free to file IP. (No IP minefield). Strong in discovery and filing IP on Synthases. Downstream process know how and IP

Strong F&F, R&D and production know how Proven production (strain) with stable high volume production In house Strain, fermentation and synthase development. Optimized synthase selection for organoleptic specification DSP engineering and up-scaling capabilities Strong partners: PRI, DSM, BIOSTREAM, University Graz, Wageningen, Berlin, Bath and Oxford.

Up scaling 40 L – 64 M3

6 Production sites with fermenters between 17M3 and 192 M3

β-Elemene

α+β Pinene

Patchouli

Sandalwood

Limonene

Carvone Menthol

Myrcene

Humulene

Nootkatone

Valencene

β-Bisabolene 4 -Cubanol

Isobionics Innovative creators of flavour and fragrances