2nd International Symposium on

Left Atrial Appendage

ISLAA 2014The Rosen Shingle Creek Hotel | Orlando, Florida

March 14 -16, 2014

www.ISLAASymposium.com

Course DirectorsDhanunjaya Lakkireddy, MD, University of Kansas Hospital, Kansas City, KS

Andrea Natale, MD, Texas Cardiac Arrhythmia Institute, Austin, TXSaibal Kar, MD, Cedars Sinai Hospital, Los Angeles, CA

Vivek Reddy, MD, Mount Sinai Medical CenterDavid R. Holmes, Jr., MD, Mayo Clinic, Rochester, MN

Sponsored by: Mid-America Cardiology, University of Kansas Hospital and University of Kansas Medical Center Continuing Education

Co-Sponsored by:

ISLAA 2014 Overview The purpose of this symposium is to update medical practitioners on the future of Left Atrial Appendage (LAA) Procedures. Participants will learn about various research studies regarding Left Atrial Appendage exclusion that includes both occlusion and ligation types of devices and gain a better understanding of the role that the LAA plays in atrial arrhythmias. An evolution of percutaneous techniques in LAA occlusion or exclusion will be discussed. An overview of the role of cardiac imaging in Left Atrial Appendage exclusion will be reviewed. The balance of anticoagulation and bleeding in the high risk patient population will be provided. A variety of topics will provide specialists and generalists an update on the evolution of left atrial appendage strategies and patient care.

ISLAA will feature live case demonstration in HD, illustrative presentations, case reviews, expert panel discussions, point-counterpoint debates, and interactive Q&A sessions.

Target AudienceThe International Symposium on Left Atrial Appendage is designed for physicians, allied health professionals, fellows and other associated healthcare professionals within the fields of electrophysiology, interventional cardiology, general cardiology, cardiothoracic surgery, family and internal medicine.

Learning ObjectivesAt the completion of this symposium, participants should be able to:• Demonstrate an understanding of the left atrial appendage (LAA) including the anatomy and pathophysiology.• Describe systemic thromboembolization and the role of LAA in patients with atrial fibrillation.• Express a working knowledge of the role of the left atrial appendage in atrial arrhythmias origin and maintenance.• Examine LAA ligation and occlusion technology.• Discuss the past, present and future of surgical left atrial appendage exclusion.• Evaluate the use of LAA ligation as an adjunctive therapy for AF ablation.• Review the role of oral anticoagulation in stroke prophylaxis.• Evaluate the systemic side effects of LAA ligation/occlusion technologies.• Discuss practical issues related to procedural performance.• Assess appropriate case selections for pharmacological and interventional therapies for stroke prophylaxis.

Accreditation All participants are required to sign attendance rosters at the beginning of each day. A certificate of completion will be provided to all activity participants based on completion of the program evaluation, documentation of actual attendance time, meeting minimum attendance requirements specific to the activity, and payment in full. If you are not paid in full, a link to complete evaluation and get your certificate will be emailed to you upon receipt of payment.

Physicians: The University of Kansas Medical Center Office of Continuing Medical Education is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

The KU Medical Center Office of Continuing Medical Education designates this live activity for a maximum of 21.5 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.Nurses: Up to 21.5 contact hours will be awarded to all individuals based on completion of the program evaluation, documentation of actual attendance time, meeting minimum attendance requirements specific to the activity, and payment in full.

University of Kansas School of Nursing is accredited as a provider of continuing nursing education by the American Nurses Credentialing Center’s Commission on Accreditation.

Acknowledgements Financial contributions and supporters of this program will be acknowledged in print at the symposium and on the conference website. ISLAA is partially funded through educational grants from multiple commercial supporters. ISLAA ensures that it is a highly educational symposium, which bridges knowledge gaps, and fulfills the clinical needs of the target audience. To support this endeavor, the program directors create organizational and scientific committees to assist in educational content development and content oversight for general sessions, case reviews, abstract sessions, live cases, and scientific symposia. These sessions are developed without influence from commercial supporters.

Samuel Asirvatham, MD, FACC, FHRSProfessor of Medicine and PediatricsDepartments of Cardiovascular Disease & Pediatric & Adolescent Medicine Mayo Clinic, Rochester, MN

Loren Berenbom, MD, FACC, FHRSProfessor of Medicine; Director, Bloch Heart Rhythm CenterMid-America Cardiology at University of Kansas Medical Center and Hospital, Kansas City, KS

John Camm, QHP, MD, FRCPBHF Professor of Clinical CardiologySt. George’s University of LondonLondon, United Kingdom

James Cox, MD Chairman and CEO of the World Heart FoundationWashington, DCEmeritus Evarts A. Graham Professor of SurgeryWashington University School of MedicineSt. Louis, MO

Luigi Di Biase, MD, PhD, FHRSAssociate Professor, Albert Einstein College of Medicine at Montefiore Hospital, New York, NYSenior Researcher, Texas Cardiac Arrhythmia Institute, St. David’s Medical Center, Austin, TX

Matthew Earnest, MD, FACC, FSCAIClinical Assistant Professor of Medicine, CardiologyMid-America Cardiology at University of Kansas Medical Center and Hospital, Kansas City, KS

James Edgerton, MDThe Heart Hospital Baylor PlanoAdjunct Assistant Clinical Professor at the University of Texas at ArlingtonChair of the Education Committee for Cardiopulmonary Research Science and Technology Institute, Plano, TX

Michael Ezekowitz, MD Director of Atrial Fibrillation Research and Education; Cardiovascular Research Foundation, New York, NYProfessor of Medicine; Thomas Jefferson Medical CollegeAttending Cardiologist; Lankenau Medical Center, and Bryn Mawr and Paoli Hospitals. Philadelphia, PA

Douglas Gibson, MD Director, Cardiac Electrophysiology LaboratoryThe Heart Rhythm Center at Torrey Pines Scripps ClinicScripps Health, La Jolla, CA

A.Marc Gillinov, MD, FACC, FAHAInstitute Experience Officer, Heart & Vascular Institute Cleveland ClinicDepartmentof Thoracic and Cardiovascular Surgery at Cleveland Clinic, Cleveland, OH

Course Directors

Symposium Faculty

Dhanunjaya Lakkireddy, MD, FACC, FHRSDirector, Center for Excellence in Atrial Fibrillation & Electrophysiology Research Professor of Medicine,

University of Kansas Medical Center and HospitalGovernor Elect Kansas ACC Chapter

Kansas City, KS

Andrea Natale, MD, FACC, FHRS, FESCExecutive Medical Director Texas Cardiac Arrhythmia

Austin, TX

Saibal Kar, MD, FACC, FSCAIDirector, Cardiovascular Intervention Center Research Cedars Sinai Hospital,

Los Angeles, CA

Vivek Reddy, MDDirector of Electrophysiology, Mount Sinai Medical Center

New York, NY

David R. Holmes Jr. MD, FACC, FSCAIProfessor of Medicine and Consultant, Department of Internal Medicine, Division of Cardiovascular Diseases,

Former President-Elect of the American College of Cardiology (ACC) Mayo Clinic,Rochester, MN

Swaminatha Gurudevan, MD, FACC, FASE, FSCCT Assistant Professor of Medicine; CardiologistCedars-Sinai Heart Institute,Los Angeles, CA

Rodney Horton, MD, FACC, FHRSCardiac ElectrophysiologistTexas Cardiac Arrhythmia Institute,Austin, TX

Réda Ibrahim, MD, CSPQ, FRCPC Interventional Cardiologist; Associate Professor of MedicineUniversite de Montreal, Montreal Heart Institute,Quebec City, Quebec

Randall Lee, PhD, MDEli and Edith Broad Center of Regeneration Medicine and Stem Cell ResearchUniversity California San Francisco, San Francisco, CA

Moussa Mansour, MD, FACC, FHRSAssociate Professor in Medicine, Harvard Medical SchoolDirector, Cardiac Electrophysiology Laboratory and Atrial Fibrillation Program, Massachusetts General Hospital,Boston, MA

Gerald Naccarelli, MD, FHRSProfessor of Medicine and Chief of the Division of CardiologyPennsylvania State University College of Medicine/Milton S. Hershey Medical Center,Hershey, PA

Jonathan Piccini, MD, MHScAssistant Professor of Medicine, CardiologyDuke University Medical Center,Durham, NC

Mathew Price, MD, FACC Director, Cardiac Catheterization LaboratoryScripps Clinic Torrey Pines,La Jolla, CA

Abdi Rasekh, MD Department of CardiologyTexas Heart Institute at St. Luke’s Episcopal Hospital,Houston, TX

Madhu Reddy, MD Assistant Professor of Medicine CardiologyMid-America Cardiology at University of Kansas Medical Center and Hospital,Kansas City, KS

Sanjeev Saksena, MD, FHRS, FACC, FESC, FAHA, FRSMClinical Professor of Medicine, Rutgers-RWJ Medical SchoolMedical Director, Electrophysiology Research Foundation,Warren, NJ

Daniel Singer, MD Professor of Medicine, Harvard Medical SchoolProfessor, Department of Epidemiology, Harvard School of Public HealthChief, Clinical Epidemiology Unit, Massachusetts General Hospital,Boston, MA

Gregg Stone, MD Director of Cardiovascular Research and EducationColumbia University Medical Center / New York-Presbyterian Hospital,New York, NY

Vijay Swarup, MD, FACC, FHRSDirector Cardiac ElectrophysiologyArizona Heart Rhythm Institute,Phoenix, AZ

Peter Tadros, MD, FACC, FSCAI, FASEAssistant Professor of Medicine; Director, Interventional Cardiology Laboratory,Mid-America Cardiology at University of Kansas Medical Center,Kansas City, KS

Zoltan Turi, MD, FACC, FSCAIProfessor of Medicine, Associate Director, Division of Cardiovascular Disease and HypertensionDirector, Structural Heart Disease ProgramRutgers Robert Wood Johnson Medical School,New Brunswick, NJ

Miguel Valderrabano, MD, FACC Chief, Division of Cardiac Electrophysiology; Associate Professor of Medicine, Weill Cornell Medical College of Cornell University, Methodist DeBakey Cardiology Associates,Houston, TX

Richard Whitlock, MDCardiovascular SurgeryPopulation Health Research Institute at McMaster University Hamilton, Ontario, Canada

Symposium Faculty

2nd International Symposium on Left Atrial Appendage - ISLAA 2014

Friday, March 14, 20147:00AM - 7:45AM Continental Breakfast and Exhibits 7:45AM - 8:00AM Welcome and Introductions Dhanunjaya Lakkireddy, Andrea Natale 8:00AM - 9:15AM Session I Moderator – Saibal Kar 8:00AM - 8:15AM Embryology, Anatomy & Histopathology of Left Atrial Appendage Samuel Asirvatham 8:15AM - 8:30AM Impact of LAA Exclusion on Cardiovascular Physiology and Systemic Homeostasis Dhanunjaya Lakkireddy 8:30AM - 8:45AM Understanding the Role of LAA in Systemic Thromboembolization Luigi Dibiase 8:45AM - 9:00AM The Role of LAA in Atrial Arrhythmias Origin and Maintenance Andrea Natale 9:00AM - 9:15AM Panel Discussion 9:15AM - 10:25AM Session II Moderator- Matthew Earnest 9:15AM - 9:30AM Risk Assessment Tools for Stroke Prophylaxis and Bleeding – Practical Use Loren Berenbom 9:30AM - 9:45AM Managing Antiplatelet Therapy and Anticoagulants in Patients with CAD and Atrial Fibrillation Peter Tadros 9:45AM - 10:15AM Debate - Everyone with CHADS2 score of 2 or more should be Considered for LAA Closure/Ligation Pro - Saibal Kar Con - Moussa Mansour 10:15AM - 10:25AM Panel Discussion 10:25AM - 10:35AM Break/Exhibitors 10:35AM - 11:45AM Session III Moderator - Madhu Reddy 10:35AM - 10:50AM Essentials of Transseptal Puncture as is Relevant to LAA Closure or Ligation TBA 10:50AM - 11:05AM Dry Pericardial Access: Rules of Engagement Randall Lee

11:05AM - 11:20AM Patient Selection: Who is a Good candidate for LAA Exclusion Rodney Horton 11:20AM - 11:35AM Understanding Thoracic Anatomy for Minimally Invasive LAA Surgical Ligation: A Surgeons’ Perspective James Cox

11:35AM - 11:45AM Panel Discussion

11:45AM - 12:45PM Lunch Break/Exhibitors

12:45PM - 1:45PM Session IV Moderator - Richard Whitlock

12:45PM - 1:00PM Evolution of Percutaneous Techniques in LAA Occlusion or Exclusion David R. Holmes, Jr.

1:00PM - 1:15PM Past, Present and Future of Surgical Left atrial Appendage Exclusion James Edgerton

1:15PM - 1:45PM Debate - Is LAA Occlusion/Exclusion good enough to Allow for Discontinuation of Coumadin in Patients with AF and Higher Risk for Thromboembolization? Pro - Mathew Price Con - Zoltan Turi

1:45PM - 2:00PM Panel Discussion

2:00PM - 6:00PM Session V Live Case Demonstration with Discussion and Expert Panel Live Case - 1 LAA Occlusion using Amplatzer Amulet Plug

Live Case - 2 LAA Ligation using the Lariat

Live Case - 3 LAA Occlusion using the Watchman Device

Live Case - 4 LAA ligation using AtriClip

6:00PM - 6:30PM Exhibitor Reception

Saturday March 15, 20146:30AM - 7:45AM Breakfast Sessions 8:00AM - 9:00AM Session VI Moderator - David R. Holmes, Jr. 8:00AM - 8:15AM How to Set up a LAA Exclusion Program Vijay Swarup 8:15AM - 8:30AM Transesophageal Echo in LAA Exclusion Swaminatha Gurudevan 8:30AM - 8:45AM The Role of CT Imaging in Left Atrial Appendage Exclusion Douglas Gibson 8:45AM - 9:00AM Panel Discussion 9:00AM - 10:15AM Session VII 9:00AM - 9:15AM Tips and Tricks to Prevent Complications during LAA exclusion Rodney Horton 9:15AM - 9:30AM Managing Complications in LAA Exclusion Procedures - Thrombus, Perforation, Device Embolization, and more David R. Holmes, Jr. 9:30AM - 9:45AM Post Procedural LAA Exclusion Leak - Mechanisms, Implications and Treatment Andrea Natale 9:45AM - 10:00AM Post Procedural Anticoagulation Management after LAA Exclusion - Understanding an Imperfect Science TBD 10:00AM - 10:15AM Panel Discussion 10:15AM - 10:30AM Break/Exhibitors 10:30AM - 11:45AM Session VIII Moderator - Loren Berenbom 10:30AM - 11:00AM Debate - Should LAA be Ligated Routinely During an Open Heart Surgery? Pro - Richard Whitlock Con - James Edgerton 11:00AM - 11:15AM Impact of Surgical Ablation or Exclusion of LAA –Implications to Rhythm Control Marc Gillinov 11:15AM - 11:30AM LAA Ligation as an Adjunctive Therapy for AF ablation – The LAALA AF Study Dhanunjaya Lakkireddy 11:30AM - 11:45AM Panel Discussion

11:45AM - 12:30PM Session IX Moderator - Randall Lee 3-Way Debate - Who should perform LAA Occlusion/Exclusion Procedures? Surgeon - James Cox EP - Dhanunjaya Lakkireddy Interventional - Saibal Kar 12:30PM - 1:15PM Lunch Break/Exhibitors 1:15PM - 2:30PM Session X - Clinical Trials in LAA Exclusion Moderator - Dhanunjaya Lakkireddy 1:15PM - 1:30PM WATCHMAN TRIALS Vivek Reddy 1:30PM - 1:45PM LARIAT TRIALS Abdi Rasekh 1:45PM - 2:00PM Amplatzer Cardiac Plug Réda Ibrahim 2:00PM - 2:15PM AtriClip & Other Surgical Tools Michael Mack 2:15PM - 2:30PM Panel Discussion 2:30PM - 3:45PM Session XI Moderator - Andrea Natale 2:30PM - 2:45PM Early Experience with Wavecrest Technology TBD 2:45PM - 3:00PM Why Should the LAA Exclusion be a Program and not a Procedure? Matthew Earnest 3:00PM - 3:15PM Cost Effectiveness of LAA Exclusion Miguel Valderrabano 3:15PM - 3:30PM LAA litigation and occlusion technology in the incubator Gregg Stone 3:30PM - 3:45PM Panel Discussion 3:45PM - 4:00PM Break/Exhibitors 4:00PM - 5:30PM Session XII - My Most Interesting Cases of LAA Exclusion with Expert Panel David R. Holmes, Jr. Saibal Kar Dhanunjaya Lakkireddy Andrea Natale Randall Lee Vijay Swarup 5:30PM - 6:00PM Exhibitor Reception

Sunday March 16, 20147:00AM - 8:00AM Poster Session - Working Breakfast (Abstracts) Moderator - Andrea Natale and Saibal Kar 8:00AM - 8:45AM Session XIII Moderator - Samuel Asirvatham 8:00AM - 8:15AM Evolution of Anticoagulation for Stroke Prophylaxis in Patients with Atrial Fibrillation TBD 8:15AM - 8:30AM Novel Anticoagulant Trial Review - RELY, Rocket, Aristotle & Engage AF Michael Ezekowitz 8:30AM - 8:45AM Panel Discussion 8:45AM - 9:00AM Break 9:00AM - 10:25AM Session XIV Moderator - Vijay Swarup 9:00AM - 9:40AM Debate: New Generation Anti-Coagulation Agents are a Better Choice than Warfarin in the Management of AF Protagonist: Sanjeev Saksena Antagonist: John Camm 9:40AM - 9:55AM Peri-procedural Management of Oral Anticoagulants Madhu Reddy 9:55AM - 10:10AM Understanding the Antidotes for Oral and Systemic Anticoagulants Gerald Naccarelli 10:10AM - 10:25AM Panel Discussion 10:25AM -10:45AM Break/Exhibitors 10:45AM - 12:00PM Session XV Moderator - David R. Holmes, Jr. 10:45AM - 11:00AM Stroke Prophylaxis on a Global Scale - Why Oral Anticoagulants are Still the Best Answer John Camm 11:00AM - 11:15AM Systemic Anticoagulation – How do you Select which Drug for Whom? Jonathan Piccini 11:15AM - 11:30AM Optimization of Stroke Prophylaxis Strategies in Nonvalvular AF - Drugs, Devices or Both? Samuel Asirvatham 11:30AM - 11:45AM Management of Non-Valvular AF & Stroke - Hurdles in Access to Appropriate Care Michael Ezekowitz 11:45AM - 12:00PM Panel Discussion 12:00PM - 12:10PM Closing Remarks and Adjourn

Planning CommitteeDonita Atkins, RN, BSN, CCRC

EP Research Manager University of Kansas Medical Center

Matthew Earnest, MD, FACC, FSCAI Clinical Assistant Professor Cardiology

Mid-America Cardiology at University of Kansas Medical Center and Hospital

Ryan Ferrell, MD, FACC, FACP Assistant Clinical Professor Cardiology

Mid-America Cardiology at University of Kansas Medical Center and Hospital

Mary Gambino, RN, PhD Assistant Dean for Community Afairs, Director of Nursing Continuing Education

University of Kansas School of Nursing

Jayant Nath, MD Clinical Assistant Professor, Cardiology

Mid-America Cardiology at University of Kansas Medical Center and Hospital

Registration and FeesPayment is required at the time of registration. Only registrations accompanied with payment will be accepted. Please register in advance. Fees include course materials, breakfast, lunch, cocktail reception, dinner lectures, refreshments and continuing education credit.

Registration FeesPhysicians $500.00Allied Health Professionals $50.00 Fellows $250.00Industry Professionals $500.00

Please visit the conference website at www.ISLAASymposium.com to register or complete the application form within this brochure and follow the outlined instructions.

Call for Abstracts Be a part of ground breaking research and share it with us at ISLAA 2014.

We are looking for abstracts on Left Atrial Appendage Interventions/Treatments for the symposium. If you have a poster abstract and would be interested in presenting during the symposium, please send your abstract to Donita Atkins at datkins2@kumc.edu. All submissions must be in by February 1, 2014. You will be notified via e-mail by February 15, 2014 if your poster will be displayed/presented.

Lodging A block of rooms has been reserved at the host hotel of ISLAA, the Rosen Shingle Creek, at the daily rate of $150.00 for single or double occupancy plus tax. To take advantage of the special rate, please visit the “Hotel” page on www.ISLAASymposium.com upon registration. Detailed information about securing your reduced room rate under the ISLAA room block is outlined.

About the Hotel Rosen Shingle Creek is nestled on a 230-acre site along Shingle Creek just off Universal Boulevard, east of the Orange County Convention Center North/South expansion and just 10 minutes away from the Orlando International Airport. Our ideal location is just a short distance to a variety of Orlando’s best attractions, restaurants, shopping and entertainment venues.

Our 1,500 guest rooms offer luxurious first-class settings that capture the hotel environment. Capitalizing on Rosen Shingle Creek’s elevation, every single room offers a stunning view of the golf course and the area’s incomparable setting —from the perfectly manicured fairways and greens to the picturesque creek, magnificent cypress trees, and lush natural vegetation. For vacationers or meeting guests, it’s hard to imagine a better way to start the day than with the view from these rooms.

Refund & Cancellation PolicyA full refund of registration fees, less a $15 administrative fee, will be available if requested in writing and received by February 28, 2014. No refunds will be made after that date. A $30 fee also will be charged for returned checks. (Please note that if you fail to cancel by the deadline and do not attend, you are still responsible for payment.)

KU Continuing Education reserves the right to cancel ISLAA 2014 and return all fees in the event of insufficient registration. The liability of the University of Kansas is limited to the registration fee. The University of Kansas will not be responsible for any losses incurred by registrants, including but not limited to airline cancellation charges or hotel deposits.

Program AccessibilityWe accommodate persons with disabilities. Please call 785-864-5823 or mark the space on the registration form and a KU Continuing Education representative will contact you to discuss your needs. To ensure accommodation, please register at least two weeks before the start of the event.

University of Kansas is committed to providing programs and activities to all persons, regardless of race, religion, color, national origin, ancestry, sex, age, disability, and veteran status. In addition, university policies prohibit discrimination on the basis of sexual orientation, marital status, and parental status.

Nondiscrimination PolicyThe University of Kansas prohibits discrimination on the basis of race, color, ethnicity, religion, sex, national origin, age, ancestry, disability, status as a veteran, sexual orientation, marital status, parental status, gender identity, gender expression and genetic information in the University’s programs and activities. The following person has been designated to handle inquiries regarding the non-discrimination policies: Director of the Office of Institutional Opportunity and Access, IOA@ku.edu, 1246 W. Campus Road, Room 153A, Lawrence, KS, 66045, (785) 864-6414, 711 TTY.

Privacy PolicyKU Continuing Education does not share, sell, or rent its mailing lists. You have our assurance that any information you provide will be held in confidence by KU Continuing Education.