Study of the Transcriptome of the Prematurely Aging Yeast Mutant dna2-1 Using a New Method Allowing Comparative DNA Microarray AnalysisIsabelle LesurThesis defense 04/25/05

IntroductionagingTranscriptome studyMicroarray dataDevelopment of a large-scale automated comparison methodYoung cells S. cerevisiaeold cells S. cerevisiae1/48

ContentI - Experimental study of the causes of aging in S. cerevisiae* Aging in yeast* The dna2-1 prematurely aging mutant* Experimental approach* Experimental Results2/48II Comparative analysis of DNA microarray experiments* Motivation* A weighted-ontology for microarray experiments* Validation* Processing of the compared datasetsIII Conclusion and perspectives

Aging in yeastdeathAsymmetric divisionSize increases with agingg1g1g1g1g1g2g3g4gn3/48

The dna2-1 prematurely aging mutant(Hoopes L.L.M. and J. L. Campbell. 2002 . MBC)Median life spans (generations) dna2-1 8.1 +/- 2.5 DNA2+ 30.4 +/- 5.41008060402001 11 21 31 41generationsPercent survival4/48

ORFs depositHybridizationReadingYeast A Yeast B Total RNAextractionRT-PCR of the mRNAData extractionExperimental procedure5/48

Experimental approachWild-typestraindna2-1mutant strain++94.39% genes within two folds variation; M [-1,1]94.36% genes within two folds variation; M [-1,1]8 101- Control (young cells vs. young cells)After Lowest Regression NormalizationAfter Lowest Regression NormalizationA = log2(sqrt(R*G))A = log2(sqrt(R*G))M = log2(G/R)M = log2(G/R)6/48Selection of genes with variation in expression level |M| > 1

2- Wild-type experiments (young cells vs. old cells)++627 genes upregulated in old wild-type cells (10.22% of the genome)387 genes downregulated in old wild-type cells (6.30% of the genome)After Lowest Regression NormalizationAfter Lowest Regression NormalizationA = log2(sqrt(R*G))A = log2(sqrt(R*G))M = log2(G/R)M = log2(G/R)7/48

3- dna2-1 experiments (young cells vs. old cells)++898 genes upregulated in old dna2-1 cells (14.63% of the genome)656 genes downregulated in old dna2-1 cells (10.69% of the genome)After Lowest Regression NormalizationAfter Lowest Regression NormalizationM = log2(G/R)M = log2(G/R)A = log2(sqrt(R*G))A = log2(sqrt(R*G))8/48

ContentI - Experimental study of the causes of aging in S. cerevisiae* Aging in yeast* The dna2-1 prematurely aging mutant* Experimental approach* Experimental ResultsII Comparative analysis of DNA microarray experiments* Motivation* A weighted-ontology for microarray experiments* Validation* Processing of the compared datasetsIII Conclusion and perspectives9/48

Glucose metabolism and energy productionGenenameRatio of expression levelold cells / young cellsTCA cycleOxidativephosphorylationGlycogenproductionGluconeogenesisGlyoxylatecycleLipid metabolismMig1-repressedgenes 9 8 7 6 5 4 3 2-1 1-2-3-4-5Compared with Lin S.S., J. K. Manchester, and J. I. Gordon. 2001. J. Biol. Chem. 10/48Shift from glycolysis toward gluconeogenesis and energy production associated with aging

The Environmental Stress Response (ESR)Compared with Gasch A. P. , P. T. Spellman, C. M. Kao, O. Carmel-Harel, M. B. Eisen, G. Storz, D. Botstein, and P. O. Brown. 2000. Mol. Biol. Cell.dna2-11553 genes11/48

The Environmental Stress Response (ESR)Compared with Gasch A. P. , P. T. Spellman, C. M. Kao, O. Carmel-Harel, M. B. Eisen, G. Storz, D. Botstein, and P. O. Brown. 2000. Mol. Biol. Cell.dna2-11147 genes1553 genes406868 genesESR462genes11/48

The Environmental Stress Response (ESR)Compared with Gasch A. P. , P. T. Spellman, C. M. Kao, O. Carmel-Harel, M. B. Eisen, G. Storz, D. Botstein, and P. O. Brown. 2000. Mol. Biol. Cell.dna2-1850 genes1553 genes29785321868 genesESR352genes11011/48Old cells react as if they were growing under external stress conditions

The Telomerase Delete Response (TDR)genes common to tlc1 and old dna2-1 cells12/481553 genes652 genesdna2-11213 genes340genestlc1312genesCompared with: Nautiyal S., J. L. DeRisi, and E. H. Blackburn. 2002. PNAS. USATeng S. C., C. Epstein, Y. L. Tsai, H. W. Cheng, H. L. Chen, and J. J. Lin. 2002. Biochem Biophys Res Commun.Similarity between expression profiles associated with aging of dna2-1 and the TDR

Genes belonging to the TDR and upregulated in old dna2-1 cellsRatio of expression levelold cells / young cellsGenename 7 6 5 4 3 2-1 1-2-3UnknownESRDNA-damagesignature genesOthersCarbohydratemetabolismDNAsynthesisOxydativephosphorylationTelomere deletionsignature genesCompared with: Nautiyal S., J. L. DeRisi, and E. H. Blackburn. 2002. PNAS. USATeng S. C., C. Epstein, Y. L. Tsai, H. W. Cheng, H. L. Chen, and J. J. Lin. 2002. Biochem Biophys Res Commun.13/48

Genes belonging to the TDR and downregulated in old dna2-1 cellsRatio of expression levelold cells / young cellsGenenameCompared with: Nautiyal S., J. L. DeRisi, and E. H. Blackburn. 2002. PNAS. USATeng S. C., C. Epstein, Y. L. Tsai, H. W. Cheng, H. L. Chen, and J. J. Lin. 2002. Biochem Biophys Res Commun.Ribosomal genesHistones 5 4 3 2-1 1-2-3-4-514/48

DNA damage repairRecombinationalrepair pathwayNER pathwayMismatchDNA repairPost-replicationrepair pathwayRatio of expression levelold cells / young cellsGenenameDNA-damage signature genes 5 4 3 2-1 1-2-3DNA-damageCheckpoint pathway15/48Activation of numerous genes repairing DNA

Chart10

2.920.12

00.67

06.28

1.87-0.724137931

2.66-0.9230769231

-0.44927536230.6

3.642.06

1.030.38

1.880

1.17-0.2195121951

2.05-0.0309278351

1.57-0.3333333333

2.74-0.6949152542

1.4-1.0408163265

1.83-0.0526315789

-0.33333333331.27

-0.01010101011.74

0.88-0.3157894737

0.911.62

1.87-0.724137931

1.09-0.1363636364

-0.05263157890.93

0.211.13

3.642.06

1.880

2.920.12

01.75

0.50.96

2.462.38

2.4627717412.376809759

0.49755411970.9578341264

-0.08067850.1666542224

01.7498212616

0.206521491.1300275306

-0.0472570.933981604

1.88249647250.0048892888

3.63784247572.06087936

2.9218685350.1228019748

0-0.3799575

1.0280252810.378467103

3.6378424762.06087936

1.168308438-0.2153610007

1.8824964730.004889289

2.05-0.0309278351

1.574164909-0.3395885008

2.736948707-0.6855644995

1.403216465-1.0526890001

Gene names

Ratio of expression level OC/YC

Sheet1

TCA cycleWT o/ydna2-1 o/yATTENTION: LES PLOTS SONT CENTRES SUR -1, +1

CIT35.364.31CIT35.364.31

IDP216.731.16IDP216.731.16

YJL200C1.05-0.75YJL200C1.05-0.75

YMR118C3.175.60YMR118C3.175.60

YJL045W0.002.33YJL045W0.002.33

SDH10.092.56SDH10.092.56

SDH20.300.81SDH20.300.81

SDH40.060.83SDH40.060.83

LSC20.191.14LSC20.191.14

oxydative phosphorylationCOX5B-0.441.08

COX5B-0.441.08QCR80.010.82

QCR80.010.82QCR90.610.76

QCR90.610.76QCR70.120.83

QCR70.120.83COX130.180.81

COX130.180.81QCR20.140.81

QCR20.140.81GSY1-3.99617792390.107666

GAC1-0.47561618041.027569

glycogen productionSGA1-3.497232

GSY1-3.99617792390.107666GLC3-1.5137533731

GAC1-0.47561618041.027569PCK118.7122024.448686

SGA1-3.497232FBP110.973538481.4415016212

GLC3-1.5137533731BIO20.9239281.044559

gluconeogenesisMLS14.360680.704805

PCK118.7122024.448686ACS12.36386602391.3610186379

FBP110.973538481.4415016212MDH20.0339551.359865

BIO20.9239281.044559POT12.3740181.595525

glyoxylate cycleACS12.3638661.361019

MLS14.360680.704805SPS191.2691042.603389

ACS12.36386602391.3610186379CAT23.9233076.396094

MDH20.0339551.359865OPI32.12806941811.5832917854

lipid metabolismOLE1-0.3018590.733216399

POT12.3740181.595525YAT23.66952597310.9815615696

ACS12.3638661.361019CHO11.49300400750.1415798781

SPS191.2691042.603389INO14.4278502999-0.002263

CAT23.9233076.396094HAP4-1.54920604980.157158

OPI32.12806941811.5832917854MLS14.360680.704805

OLE1-0.3018590.733216399

YAT23.66952597310.9815615696

CHO11.49300400750.1415798781

INO14.4278502999-0.002263

other Mig1p-repressed genes

HAP4-1.54920604980.157158

MLS14.360680.704805

GENES DOWNREGULATED IN ESR AND IN OLD WILD-TYPE CELLS

NameIDmean of the normalized ratios Wtoc/Wtycmean of the normalized ratios dna2-1oc/dna2-1ycRPL12A0.46381855790.6681434865RPL12A-1.1560155-0.4966845

YEL054CRPL12A0.46381855790.6681434865RPS22B0.36078433070.5066395108RPS22B-1.771739-0.97379

YLR367WRPS22B0.36078433070.5066395108RPL6A0.432705060.7404459336RPL6A-1.311043-0.3505375

YML073CRPL6A0.432705060.7404459336DED810.36211751110.6077420257DED81-1.7615345-0.645435

YHR019CDED810.36211751110.6077420257YDR365C0.46752676011.0095900963YDR365C-1.1389150.0095900963

YDR365CYDR365C0.46752676011.0095900963RPL35A0.45282841150.603816604RPL35A-1.208342-0.656132

YDL191WRPL35A0.45282841150.603816604RPL19A0.34160723130.5456795142RPL19A-1.9273385-0.8325775

YBR084C-ARPL19A0.34160723130.5456795142RPL8A0.39243379790.6005008778RPL8A-1.5482005-0.6652765

YHL033CRPL8A0.39243379790.6005008778RPL7A0.40287077660.5845924236RPL7A-1.4821855-0.7105935

YGL076CRPL7A0.40287077660.5845924236PDC50.44460351371.2790021737PDC5-1.2491950.2790021737

YLR134WPDC50.44460351371.2790021737RPL11B0.45830375360.4896429499RPL11B-1.181959-1.0423045

YGR085CRPL11B0.45830375360.4896429499RPS29A0.36855720540.5989083697RPS29A-1.713283-0.6697045

YLR388WRPS29A0.36855720540.5989083697RPS10A0.483379480.5895225339RPS10A-1.068768-0.696288

YOR293WRPS10A0.483379480.5895225339RPP2B0.48023439281.1733522321RPP2B-1.08231650.1733522321

YDR382WRPP2B0.48023439281.1733522321RPL100.40903969550.4940977553RPL10-1.4447505-1.023891

YLR075WRPL100.40903969550.4940977553RPL12B0.38254529960.6243658784RPL12B-1.6140695-0.601625

YDR418WRPL12B0.38254529960.6243658784CDC190.24768185270.9326696456CDC19-3.0374375-0.072191

YAL038WCDC190.24768185270.9326696456RPS150.44833871450.7981868388RPS15-1.2304565-0.2528395

YOL040CRPS150.44833871450.7981868388RPS11B0.35327949350.6230834343RPS11B-1.83062-0.6049215

YBR048WRPS11B0.35327949350.6230834343RPL2B0.34828327690.5971234771RPL2B-1.871226-0.6746955

YIL018WRPL2B0.34828327690.5971234771RPL20B0.40464115310.5591557419RPL20B-1.4713255-0.7884105

YOR312CRPL20B0.40464115310.5591557419RPL13A0.33461759570.5658049552RPL13A-1.988486-0.7673935

YDL082WRPL13A0.33461759570.5658049552RPL24B0.39794778330.5531539455RPL24B-1.5128925-0.807815

YGR148CRPL24B0.39794778330.5531539455RPL280.3487834520.5578791221RPL28-1.8671085-0.792503

YGL103WRPL280.3487834520.5578791221RPS25A0.31292939780.4897894811RPS25A-2.195609-1.0416935

YGR027CRPS25A0.31292939780.4897894811RPL42B0.36318555130.6388478252RPL42B-1.7534135-0.565318

YHR141CRPL42B0.36318555130.6388478252RPL43A0.36538409540.5941311723RPL43A-1.736846-0.68313

YPR043WRPL43A0.36538409540.5941311723RPL30.38861482910.821908801RPL3-1.573242-0.21668

YOR063WRPL30.38861482910.821908801GLN40.45338653670.5643836127GLN4-1.2056235-0.7718445

YOR168WGLN40.45338653670.5643836127RPL40B0.41415876280.4858155227RPL40B-1.414533-1.0583945

YKR094CRPL40B0.41415876280.4858155227YLR339C0.23482165650.7843912418YLR339C-3.258551-0.274874

YLR339CYLR339C0.23482165650.7843912418RPP2A0.36027149340.7667171167RPP2A-1.7756845-0.304262

YOL039WRPP2A0.36027149340.7667171167RPS24A0.42469436340.570001938RPS24A-1.3546345-0.75438

YER074WRPS24A0.42469436340.570001938RPS10B0.42130266360.5111719179RPS10B-1.3735905-0.956289

YMR230WRPS10B0.42130266360.5111719179RPS26B0.3018968633-RPS26B-2.3123895-

YER131WRPS26B0.3018968633-EGD20.42695649610.5707068718EGD2-1.342159-0.752213

YHR193CEGD20.42695649610.5707068718RPL17B0.37750714290.6468386891RPL17B-1.6489565-0.5459805

YJL177WRPL17B0.37750714290.6468386891STM10.34945674330.7258015934STM1-1.8615845-0.377787

YLR150WSTM10.34945674330.7258015934RPS9B0.33798262230.5220951994RPS9B-1.958732-0.9153595

YBR189WRPS9B0.33798262230.5220951994ARO40.44936165930.4864064003ARO4-1.225379-1.055894

YBR249CARO40.44936165930.4864064003RPS27B0.34831924640.5392139285RPS27B-1.8709295-0.8545515

YHR021CRPS27B0.34831924640.5392139285YJL188C0.29929447310.6688032702YJL188C-2.341191-0.495208

YJL188CYJL188C0.29929447310.6688032702RPS21A0.42583597990.5107027985RPS21A-1.348322-0.958086

YKR057WRPS21A0.42583597990.5107027985RPP1A0.46411476260.9272687484RPP1A-1.1546395-0.078436

YDL081CRPP1A0.46411476260.9272687484YPL142C0.46283911060.6331883121YPL142C-1.160578-0.579309

YPL142CYPL142C0.46283911060.6331883121RPS14A0.33448172060.5889264166RPS14A-1.9897-0.698005

YCR031CRPS14A0.33448172060.5889264166RPL24A0.41050793580.563356954RPL24A-1.4360065-0.7750735

YGL031CRPL24A0.41050793580.563356954RPL300.41145972950.6294068313RPL30-1.4303715-0.5887975

YGL030WRPL300.41145972950.6294068313YGR265W0.10571241340.9850901678YGR265W-8.459627-0.0151355

YGR265WYGR265W0.10571241340.9850901678YDR417C0.40814327460.5706130838YDR417C-1.45012-0.752501

YDR417CYDR417C0.40814327460.5706130838RPS21B0.34023378480.5556906192RPS21B-1.9391555-0.7995625

YJL136CRPS21B0.34023378480.5556906192RPL2A0.38461982250.5247696524RPL2A-1.59997-0.905598

YFR031C-ARPL2A0.38461982250.5247696524RPS120.45665989360.8022102497RPS12-1.1898135-0.246556

YOR369CRPS120.45665989360.8022102497RPS29B0.26133286290.7447777118RPS29B-2.8265375-0.3426825

YDL061CRPS29B0.26133286290.7447777118RPS130.36382098620.5280618677RPS13-1.7486045-0.8937175

YDR064WRPS130.36382098620.5280618677RPS8B0.30372445150.6296408466RPS8B-2.292458-0.588207

YER102WRPS8B0.30372445150.6296408466RPP00.24497009040.7037540351RPP0-3.082131-0.420951

YLR340WRPP00.24497009040.7037540351RPS26A0.33281447560.6463338651RPS26A-2.004677-0.547188

YGL189CRPS26A0.33281447560.6463338651RPL250.3924688370.5375270477RPL25-1.547973-0.8603715

YOL127WRPL250.3924688370.5375270477RPS8A0.34003126930.5689168847RPS8A-1.940906-0.757726

YBL072CRPS8A0.34003126930.5689168847RPL26A0.41698426970.5796886376RPL26A-1.398172-0.725064

YLR344WRPL26A0.41698426970.5796886376RPL13B0.27855657550.5454600001RPL13B-2.589935-0.833315

YMR142CRPL13B0.27855657550.5454600001RPL37A0.37791559520.5403503956RPL37A-1.6460935-0.850651

YLR185WRPL37A0.37791559520.5403503956RPL37B0.2754595940.5649805294RPL37B-2.6302965-0.7699725

YDR500CRPL37B0.2754595940.5649805294RPL7B0.37221441710.5670038355RPL7B-1.6866235-0.7636565

YPL198WRPL7B0.37221441710.5670038355RPL4A0.46074742910.5949553144RPL4A-1.1703865-0.6807985

YBR031WRPL4A0.46074742910.5949553144RPL6B0.34079823470.6719371174RPL6B-1.9342875-0.4882345

YLR448WRPL6B0.34079823470.6719371174RPS30B0.42335290850.5130529653RPS30B-1.3620955-0.9491165

YOR182CRPS30B0.42335290850.5130529653RPL22A0.28784855940.5174505007RPL22A-2.474049-0.932552

YLR061WRPL22A0.28784855940.5174505007YLL044W0.32132127310.7127444045YLL044W-2.11215-0.4030275

YLL044WYLL044W0.32132127310.7127444045RPL34B0.46201412280.7982311198RPL34B-1.164436-0.25277

YIL052CRPL34B0.46201412280.7982311198RPL42A0.35809718610.572882055RPL42A-1.792538-0.74556

YNL162WRPL42A0.35809718610.572882055RPL18A0.25026543780.5159780338RPL18A-2.9957575-0.938067

YOL120CRPL18A0.25026543780.5159780338YPR044C0.34501823850.6491032314YPR044C-1.8983975-0.540587

YPR044CYPR044C0.34501823850.6491032314SCP1600.38751849430.4656504776SCP160-1.580522-1.1475335

YJL080CSCP1600.38751849430.4656504776YLR062C0.23833490650.4780296383YLR062C-3.1957765-1.0919205

YLR062CYLR062C0.23833490650.4780296383RPS19A0.30538817740.5461562072RPS19A-2.274521-0.830978

YOL121CRPS19A0.30538817740.5461562072RPS22A0.45271279090.4775283515RPS22A-1.208906-1.0941165

YJL190CRPS22A0.45271279090.4775283515RPL17A0.28175323770.6660909421RPL17A-2.549205-0.5012965

YKL180WRPL17A0.28175323770.6660909421YKL078W0.44935156320.4799694355YKL078W-1.225429-1.083466

YKL078WYKL078W0.44935156320.4799694355RPS11A0.35645153210.5287611707RPS11A-1.8054305-0.891213

YDR025WRPS11A0.35645153210.5287611707RPL320.47004795660.6205134935RPL32-1.1274425-0.6115685

YBL092WRPL320.47004795660.6205134935RPL390.23068934130.4926875317RPL39-3.334834-1.029684

YJL189WRPL390.23068934130.4926875317RPL8B0.27496280780.6754550118RPL8B-2.6368555-0.4804835

YLL045CRPL8B0.27496280780.6754550118

YGR272C0.96670241850.1844707028YGR272C-0.0344445-4.420915

SUP450.92720942420.3701665731SUP45-0.078505-1.7014865

YOL022C0.56466597040.3846910652YOL022C-0.7709585-1.5994885

DPH50.57495931440.4216610663DPH5-0.7392535-1.371573

CCT51.57659699420.447670357CCT50.5765969942-1.2337865

YOL041C0.79821455370.3808158675YOL041C-0.252796-1.625941

GENES DOWNREGULATED IN ESR AND THE OLD DNA2-1 CELLSYOL077C1.07174760770.3225194185YOL077C0.0717476077-2.1005885

NameIDmean of the normalized ratios Wtoc/Wtycmean of the normalized ratios dna2-1oc/dna2-1ycNUC10.94425050590.4255178819NUC1-0.059041-1.3500775

YGR272CYGR272C0.96670241850.1844707028CCT30.88624119410.4606038609CCT3-0.128361-1.171063

YBR143CSUP450.92720942420.3701665731YBR061C1.26398440750.3649390634YBR061C0.2639844075-1.7401835

YOL022CYOL022C0.56466597040.3846910652YGL099W0.80626175130.2983079081YGL099W-0.240292-2.352241

YLR172CDPH50.57495931440.4216610663YNL163C1.14873274680.4397707563YNL163C0.1487327468-1.273912

YJR064WCCT51.57659699420.447670357GCN30.50025775780.4240686075GCN3-0.9989695-1.358109

YOL041CYOL041C0.79821455370.3808158675YGR103W0.86332525260.4146597996YGR103W-0.158312-1.4116155

YOL077CYOL077C1.07174760770.3225194185MRT40.75652979780.2414037629MRT4-0.321825-3.1424375

YJL208CNUC10.94425050590.4255178819SSF21.29974700420.4546036231SSF20.2997470042-1.1997185

YJL014WCCT30.88624119410.4606038609KAP1231.4695195920.2573593515KAP1230.469519592-2.8856175

YBR061CYBR061C1.26398440750.3649390634NMD31.07427540120.337233893NMD30.0742754012-1.965301

YGL099WYGL099W0.80626175130.2983079081SPB11.70865545050.455779893SPB10.7086554505-1.1940415

YNL163CYNL163C1.14873274680.4397707563YGR145W0.90966772110.3531022326YGR145W-0.0993025-1.832041

YKR026CGCN30.50025775780.4240686075YGR200C1.04500578670.3066011848YGR200C0.0450057867-2.261566

YGR103WYGR103W0.86332525260.4146597996RPA340.88975372950.334836414RPA34-0.1239065-1.986533

YKL009WMRT40.75652979780.2414037629YMR212C0.94753633450.308514475YMR212C-0.0553685-2.241339

YDR312WSSF21.29974700420.4546036231YJR041C0.60079148270.2964951897YJR041C-0.664471-2.372736

YER110CKAP1231.4695195920.2573593515PMA10.63417190940.4166697049PMA1-0.5768595-1.3999825

YHR170WNMD31.07427540120.337233893YMR131C0.58875097070.4041645111YMR131C-0.698511-1.47424

YCL054WSPB11.70865545050.455779893YCR072C1.04605136530.3550308673YCR072C0.0460513653-1.8166565

YGR145WYGR145W0.90966772110.3531022326YOR206W0.55686418640.3354410773YOR206W-0.79577-1.9811495

YGR200CYGR200C1.04500578670.3066011848YOL124C1.49594337560.0570120162YOL124C0.4959433756-16.540162

YJL148WRPA340.88975372950.334836414NPT10.58572511740.4463947929NPT1-0.7072855-1.2401695

YMR212CYMR212C0.94753633450.308514475YDR091C0.67721909460.2283965421YDR091C-0.476627-3.37835

YJR041CYJR041C0.60079148270.2964951897YCL045C1.02239609770.4618201718YCL045C0.0223960977-1.165345

YGL008CPMA10.63417190940.4166697049YMR215W0.89991828740.3248912508YMR215W-0.111212-2.077953

YMR131CYMR131C0.58875097070.4041645111YDR412W1.04437497030.4559256659YDR412W0.0443749703-1.19334

YCR072CYCR072C1.04605136530.3550308673LOS11.4277107230.2314138786LOS10.427710723-3.321262

YOR206WYOR206W0.55686418640.3354410773CGR10.81173673920.2652866103CGR1-0.2319265-2.769508

YOL124CYOL124C1.49594337560.0570120162YGR245C1.09195816490.4471185112YGR245C0.0919581649-1.2365435

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YDR091CYDR091C0.67721909460.2283965421FRS10.65472684960.3732383616FRS1-0.5273545-1.679253

YCL045CYCL045C1.02239609770.4618201718YLR221C0.58837079250.3632818666YLR221C-0.6996085-1.7526835

YMR215WYMR215W0.89991828740.3248912508YPR144C0.65436653880.3980563704YPR144C-0.5281955-1.512207

YDR412WYDR412W1.04437497030.4559256659YNL132W0.80190725620.2612505253YNL132W-0.247027-2.8277435

YKL205WLOS11.4277107230.2314138786YLR222C0.65859167410.2192087834YLR222C-0.5183915-3.561861

YGL029WCGR10.81173673920.2652866103MTR40.81625889770.2210969615MTR4-0.2251015-3.5229025

YGR245CYGR245C1.09195816490.4471185112ASN10.70120547740.3587456816ASN1-0.4261155-1.78749

YNR054CYNR054C0.78063067930.3890389823RPS27A0.61010821180.3862730904RPS27A-0.6390535-1.588842

YLR060WFRS10.65472684960.3732383616ECM11.68836924640.4631809368ECM10.6883692464-1.1589835

YLR221CYLR221C0.58837079250.3632818666HAS11.16808306470.2432379249HAS10.1680830647-3.111201

YPR144CYPR144C0.65436653880.3980563704YJR070C0.7518115840.1988727099YJR070C-0.3301205-4.028342

YNL132WYNL132W0.80190725620.2612505253YDL201W1.12540753820.4573871803YDL201W0.1254075382-1.1863315

YLR222CYLR222C0.65859167410.2192087834TYS10.73439151810.3350546206TYS1-0.3616715-1.984588

YJL050WMTR40.81625889770.2210969615YJR071W0.7246933460.3721135847YJR071W-0.379894-1.6873515

YPR145WASN10.70120547740.3587456816CBF50.83383363350.4553598242CBF5-0.19928-1.1960655

YKL156WRPS27A0.61010821180.3862730904CDC600.51532711680.3680974369CDC60-0.940515-1.716672

YAL059WECM11.68836924640.4631809368YPL226W1.75126747980.349686541YPL226W0.7512674798-1.859704

YMR290CHAS11.16808306470.2432379249DCD10.76229709080.4140185865DCD1-0.3118245-1.4153505

YJR070CYJR070C0.7518115840.1988727099POL320.71117761410.4475258088POL32-0.4061185-1.234508

YDL201WYDL201W1.12540753820.4573871803YLR002C0.96327652730.3962527958YLR002C-0.0381235-1.5236415

YGR185CTYS10.73439151810.3350546206YOR287C1.27943827540.4645391702YOR287C0.2794382754-1.152671

YJR071WYJR071W0.7246933460.3721135847HGH10.58343601810.3230397263HGH1-0.713984-2.0955945

YLR175WCBF50.83383363350.4553598242YNL247W0.69265484560.2833399777YNL247W-0.4437205-2.529329

YPL160WCDC600.51532711680.3680974369HIS60.61521405910.4313027456HIS6-0.6254505-1.318557

YPL226WYPL226W1.75126747980.349686541IMP41.12551647140.4458744132IMP40.1255164714-1.242784

YHR144CDCD10.76229709080.4140185865RPB101.23512980910.4183451896RPB100.2351298091-1.3903705

YJR043CPOL320.71117761410.4475258088YDR398W0.76205456010.4566846068YDR398W-0.312242-1.189695

YLR002CYLR002C0.96327652730.3962527958YNL182C1.12749295740.3570583746YNL182C0.1274929574-1.8006625

YOR287CYOR287C1.27943827540.4645391702RPA490.65755233380.2127795391RPA49-0.5207915-3.6997

YGR187CHGH10.58343601810.3230397263ZUO10.50269317870.4411050829ZUO1-0.989285-1.2670335

YNL247WYNL247W0.69265484560.2833399777IMP30.77462543960.398749124IMP3-0.2909465-1.5078425

YIL020CHIS60.61521405910.4313027456RPA1351.0516701310.252228979RPA1350.051670131-2.9646515

YNL075WIMP41.12551647140.4458744132YDR496C0.56427644810.278592118YDR496C-0.772181-2.589477

YOR210WRPB101.23512980910.4183451896GCD110.97035798930.3833370293GCD11-0.0305475-1.6086705

YDR398WYDR398W0.76205456010.4566846068YNL174W0.64477837520.4256886045YNL174W-0.5509205-1.349135

YNL182CYNL182C1.12749295740.3570583746YNL175C0.99853465040.3417220399YNL175C-0.0014675-1.926355

YNL248CRPA490.65755233380.2127795391YLR003C1.64557993120.3409175557YLR003C0.6455799312-1.9332605

YGR285CZUO10.50269317870.4411050829NOP580.48972699680.3294367554NOP58-1.041954-2.035484

YHR148WIMP30.77462543960.398749124YDR324C1.01754916160.2325746091YDR324C0.0175491616-3.2996955

YPR010CRPA1351.0516701310.252228979RLP70.71758970230.3276201297RLP7-0.393554-2.0523155

YDR496CYDR496C0.56427644810.278592118RPO261.1601789460.4270595159RPO260.160178946-1.341594

YER025WGCD110.97035798930.3833370293MPP100.68386495860.3473883776MPP10-0.462277-1.8786225

YNL174WYNL174W0.64477837520.4256886045PPT10.81905515440.321377656PPT1-0.220919-2.111604

YNL175CYNL175C0.99853465040.3417220399ECM160.94445562050.3309508184ECM16-0.058811-2.021597

YLR003CYLR003C1.64557993120.3409175557YJR003C0.65660787180.2591908425YJR003C-0.522979-2.858161

YOR310CNOP580.48972699680.3294367554YDR165W-0.2351247725YDR165W--3.253061

YDR324CYDR324C1.01754916160.2325746091KRR10.99836467870.3627501321KRR1-0.001638-1.7567185

YNL002CRLP70.71758970230.3276201297YHR088W0.9913578380.4571994976YHR088W-0.0087175-1.187229

YPR187WRPO261.1601789460.4270595159FEN11.11590703160.3552508924FEN10.1159070316-1.814912

YJR002WMPP100.68386495860.3473883776GAR10.77140672960.4160313521GAR1-0.296333-1.403665

YGR123CPPT10.81905515440.321377656DIM11.18784384370.3967979989DIM10.1878438437-1.520174

YMR128WECM160.94445562050.3309508184YHR197W0.67767619410.1382840881YHR197W-0.475631-6.23149

YJR003CYJR003C0.65660787180.2591908425RPC400.69840986040.3090215281RPC40-0.431824-2.2360205

[YDR165W][YDR165W]-0.2351247725YDR190C0.9846784040.4339558285YDR190C-0.01556-1.304382

YCL059CKRR10.99836467870.3627501321YDR101C1.08512949390.3277332998YDR101C0.0851294939-2.0512615

YHR088WYHR088W0.9913578380.4571994976YNL114C1.46693169230.390742757YNL114C0.4669316923-1.5592285

YCR034WFEN11.11590703160.3552508924ARO71.07869396050.4152248848ARO70.0786939605-1.4083335

YHR089CGAR10.77140672960.4160313521THR10.58927918490.3012555427THR1-0.6969885-2.319441

YPL266WDIM11.18784384370.3967979989YNL010W0.56576238040.3854510722YNL010W-0.7675265-1.594363

YHR197WYHR197W0.67767619410.1382840881TIF46310.81461749640.3197126678TIF4631-0.22757-2.1278085

YPR110CRPC400.69840986040.3090215281ASN20.79567819430.4384914841ASN2-0.2567895-1.280546

YDR190CYDR190C0.9846784040.4339558285ROK10.68708193210.3637790312ROK1-0.4554305-1.7489215

YDR101CYDR101C1.08512949390.3277332998YOR169C0.65863852170.4489452704YOR169C-0.5182835-1.227443

YNL114CYNL114C1.46693169230.390742757NOP40.97021865330.2875169761NOP4-0.0306955-2.4780555

YPR060CARO71.07869396050.4152248848VAS10.50546023420.3801097681VAS1-0.978395-1.630819

YHR025WTHR10.58927918490.3012555427SSH10.7750156650.3815305633SSH1-0.2902965-1.621022

YNL010WYNL010W0.56576238040.3854510722PWP10.65094059290.3503646157PWP1-0.5362385-1.8541695

YGR162WTIF46310.81461749640.3197126678MIS10.66475748320.3878677301MIS1-0.504308-1.5781985

YGR124WASN20.79567819430.4384914841DBP30.7686253290.3828049381DBP3-0.301024-1.6122965

YGL171WROK10.68708193210.3637790312YPL044C0.63713868660.3609613773YPL044C-0.569517-1.7703795

YOR169CYOR169C0.65863852170.4489452704HCA40.81234537510.3862872656HCA4-0.2310035-1.588747

YPL043WNOP40.97021865330.2875169761YHR052W0.61575274080.2707336272YHR052W-0.6240285-2.6936675

YGR094WVAS10.50546023420.3801097681YML093W1.0082301830.3495363837YML093W0.008230183-1.8609325

YBR283CSSH10.7750156650.3815305633ARO20.68913024530.3574191549ARO2-0.4511045-1.7978355

YLR196WPWP10.65094059290.3503646157AAH10.51661525050.2388892034AAH1-0.9356765-3.186041

YBR084WMIS10.66475748320.3878677301PRT10.62680814560.4122668348PRT1-0.5953845-1.4256135

YGL078CDBP30.7686253290.3828049381YNL119W-0.1902636931YNL119W--4.2558635

YPL044CYPL044C0.63713868660.3609613773YNR053C0.89350134140.4217461598YNR053C-0.1191925-1.3710945

YJL033WHCA40.81234537510.3862872656YOR243C0.5364945020.281327664YOR243C-0.863952-2.554574

YHR052WYHR052W0.61575274080.2707336272MES10.72980421910.2305783562MES1-0.3702305-3.3369205

YML093WYML093W1.0082301830.3495363837SUB20.72639708860.4272753803SUB2-0.3766575-1.340411

YGL148WARO20.68913024530.3574191549NCL10.67911391930.2760242189NCL1-0.472507-2.6228705

YNL141WAAH10.51661525050.2388892034TIF30.91689199290.3358033911TIF3-0.090641-1.977933

YOR361CPRT10.62680814560.4122668348RPG10.51272795890.4035051687RPG1-0.950352-1.478283

[YNL119W][YNL119W]-0.1902636931FUR11.00563406480.371268841FUR10.0056340648-1.693466

YNR053CYNR053C0.89350134140.4217461598MAK160.98494899440.3425153126MAK16-0.015281-1.9195775

YOR243CYOR243C0.5364945020.281327664RMT20.78935382710.3814740922RMT2-0.266859-1.62141

YGR264CMES10.72980421910.2305783562PRO10.85961831230.3847590033PRO1-0.163307-1.5990295

YDL084WSUB20.72639708860.4272753803RRP30.72299809960.3718319453RRP3-0.3831295-1.689387

YBL024WNCL10.67911391930.2760242189APT11.07177287850.3354244814APT10.0717728785-1.981297

YPR163CTIF30.91689199290.3358033911YLR243W0.92758441250.4579786289YLR243W-0.078069-1.183508

YBR079CRPG10.51272795890.4035051687TIF20.50255612610.408261498TIF2-0.9898275-1.4494105

YHR128WFUR11.00563406480.371268841YER006W0.94876345290.3595918058YER006W-0.0540035-1.780931

YAL025CMAK160.98494899440.3425153126YDL060W0.8641892090.4553968396YDL060W-0.157154-1.195887

YDR465CRMT20.78935382710.3814740922SSF10.93995828470.3955303488SSF1-0.063877-1.528251

YDR300CPRO10.85961831230.3847590033YER126C0.89429400180.2840661744YER126C-0.1182005-2.5203065

YHR065CRRP30.72299809960.3718319453URA70.99592219660.4130278909URA7-0.0040945-1.421144

YML022WAPT11.07177287850.3354244814YDL062W0.71809624070.4615398817YDL062W-0.392571-1.16666

YLR243WYLR243W0.92758441250.4579786289ELP30.71406894340.3028071892ELP3-0.400425-2.3024315

YJL138CTIF20.50255612610.408261498YVH11.09947560510.4149371567YVH10.0994756051-1.4100035

YER006WYER006W0.94876345290.3595918058DBP90.50946963960.2851711569DBP9-0.9628255-2.506666

YDL060WYDL060W0.8641892090.4553968396SIK10.61920175610.2503058111SIK1-0.6149825-2.995113

YHR066WSSF10.93995828470.3955303488YPL183C0.91133278770.2370534446YPL183C-0.097294-3.218458

YER126CYER126C0.89429400180.2840661744RPB50.95276750380.4241945288RPB5-0.049574-1.357409

YBL039CURA70.99592219660.4130278909YLR409C0.84196310430.3012440173YLR409C-0.1877005-2.319568

YDL062WYDL062W0.71809624070.4615398817GIS20.72321169640.4627682147GIS2-0.382721-1.160909

YPL086CELP30.71406894340.3028071892RPS7B0.51082671690.3878880408RPS7B-0.957611-1.5780635

YIR026CYVH11.09947560510.4149371567YNR024W0.64944996460.3999007446YNR024W-0.5397645-1.5006205

YLR276CDBP90.50946963960.2851711569ARD10.71741646850.4075238687ARD1-0.3938905-1.453844

YLR197WSIK10.61920175610.2503058111YGR128C1.25383438230.2396678874YGR128C0.2538343823-3.1724405

YPL183CYPL183C0.91133278770.2370534446YMR049C0.88866652480.279499729YMR049C-0.1252815-2.577821

YBR154CRPB50.95276750380.4241945288SUI20.85368846770.4409428681SUI2-0.1713875-1.2678675

YLR409CYLR409C0.84196310430.3012440173SAH11.21831690740.457607682SAH10.2183169074-1.185278

YNL255CGIS20.72321169640.4627682147YML060W-0.275036769YML060W--2.6358775

YNL096CRPS7B0.51082671690.3878880408YLR186W0.82114447010.4580328542YLR186W-0.2178125-1.1832495

YNR024WYNR024W0.64944996460.3999007446DBP81.42085214190.406268974DBP80.4208521419-1.4614235

YHR013CARD10.71741646850.4075238687YDR341C0.5674864860.2337617134YDR341C-0.7621565-3.2778605

YGR128CYGR128C1.25383438230.2396678874LCP50.75504321680.4306138918LCP5-0.3244275-1.322266

YMR049CYMR049C0.88866652480.279499729YFR001W0.87216312590.3954064056YFR001W-0.1465745-1.5290435

YJR007WSUI20.85368846770.4409428681YBL028C1.45985508020.277389548YBL028C0.4598550802-2.6050385

YER043CSAH11.21831690740.457607682RRP10.98200379840.3857651874RRP1-0.018326-1.5922505

[YML060W][YML060W]-0.275036769RPL33B0.50391034430.3860864482RPL33B-0.98448-1.5900935

YLR186WYLR186W0.82114447010.4580328542YBL077W0.51101688530.2928543252YBL077W-0.9568825-2.414667

YHR169WDBP81.42085214190.406268974YLR198C0.6570822460.2585397957YLR198C-0.5218795-2.8678765

YDR341CYDR341C0.5674864860.2337617134SKI80.78099678620.3559698728SKI8-0.280415-1.8092265

YER127WLCP50.75504321680.4306138918RRP51.0625372220.2221922016RRP50.062537222-3.500608

YFR001WYFR001W0.87216312590.3954064056GAS11.48463660920.4012092447GAS10.4846366092-1.492465

YBL028CYBL028C1.45985508020.277389548YDL167C-0.4273510666YDL167C--1.3399965

YDR087CRRP10.98200379840.3857651874YNL022C0.76524326320.4484456761YNL022C-0.306774-1.2299245

YOR234CRPL33B0.50391034430.3860864482MAK110.84254480550.4298763181MAK11-0.1868805-1.3262505

YBL077WYBL077W0.51101688530.2928543252NIP10.50138092840.3484537279NIP1-0.9944915-1.8698215

YLR198CYLR198C0.6570822460.2585397957YMR093W0.67363724030.4184138933YMR093W-0.4844785-1.389978

YGL213CSKI80.78099678620.3559698728YER049W1.29092390130.4240927067YER049W0.2909239013-1.357975

YMR229CRRP51.0625372220.2221922016VMA60.50049073120.4199620564VMA6-0.998039-1.3811675

YMR307WGAS11.48463660920.4012092447PUS40.85884127710.4111022267PUS4-0.1643595-1.432485

[YDL167C][YDL167C]-0.4273510666YOR252W1.23290576160.3264600436YOR252W0.2329057616-2.063162

YNL022CYNL022C0.76524326320.4484456761YNL120C0.55104069550.4092299357YNL120C-0.814748-1.443614

YKL021CMAK110.84254480550.4298763181YLR076C0.49079056050.4440852288YLR076C-1.037529-1.25182

YMR309CNIP10.50138092840.3484537279YKR081C1.40446380730.3917634861YKR081C0.4044638073-1.5525605

YMR093WYMR093W0.67363724030.4184138933YNL110C0.73667755480.403991517YNL110C-0.357446-1.4752995

YER049WYER049W1.29092390130.4240927067SUR40.98133645270.4484696087SUR4-0.0190185-1.2298055

YLR447CVMA60.50049073120.4199620564YCR057C-0.3029879765YCR057C--2.300461

YNL292WPUS40.85884127710.4111022267RPS23B0.59289844040.4140941928RPS23B-0.6866295-1.4149095

YOR252WYOR252W1.23290576160.3264600436TIF51.60201597690.4151034562TIF50.6020159769-1.409038

YNL120CYNL120C0.55104069550.4092299357YOR271C1.21266727990.3830972146YOR271C0.2126672799-1.6103035

YLR076CYLR076C0.49079056050.4440852288YLL034C-0.3524720362YLL034C--1.8371045

YKR081CYKR081C1.40446380730.3917634861NIP71.37474335260.2594323439NIP70.3747433526-2.8545695

YNL110CYNL110C0.73667755480.403991517PUS11.15787176220.2802894044PUS10.1578717622-2.567741

YLR372WSUR40.98133645270.4484696087YTM10.90027435860.4320445732YTM1-0.1107725-1.314576

[YCR057C][YCR057C]-0.3029879765YOR004W0.76779705590.3689862619YOR004W-0.3024275-1.710128

YPR132WRPS23B0.59289844040.4140941928YGR173W0.98811690610.4400172839YGR173W-0.012026-1.272638

YPR041WTIF51.60201597690.4151034562RPB90.72095428390.3597741554RPB9-0.3870505-1.7795215

YOR271CYOR271C1.21266727990.3830972146FUN111.33136114370.2950556202FUN110.3313611437-2.3891915

[YLL034C][YLL034C]-0.3524720362YDR339C0.57642170090.4257006554YDR339C-0.734841-1.3490685

YPL211WNIP71.37474335260.2594323439WRS10.66943702020.230126055WRS1-0.4937925-3.3454445

YPL212CPUS11.15787176220.2802894044RRP90.73956346530.457312507RRP9-0.352149-1.1866885

YOR272WYTM10.90027435860.4320445732YER070W-0.1536412673YER070W--5.508668

YOR004WYOR004W0.76779705590.3689862619YJL109C-0.0206896241YJL109C--47.333406

YGR173WYGR173W0.98811690610.4400172839DBP100.8766001240.3222362162DBP10-0.140771-2.1033135

YGL070CRPB90.72095428390.3597741554CAF200.7542794990.3659511711CAF20-0.3257685-1.732605

YAL036CFUN111.33136114370.2950556202YHR196W-0.3986777454YHR196W--1.5082915

YDR339CYDR339C0.57642170090.4257006554BMS11.19647709280.3784366065BMS10.1964770928-1.6424505

YOL097CWRS10.66943702020.230126055YOR277C0.79117178870.3016752327YOR277C-0.263948-2.314823

YPR137WRRP90.73956346530.457312507

[YER070W][YER070W]-0.1536412673

[YJL109C][YJL109C]-0.0206896241

YDL031WDBP100.8766001240.3222362162

YOR276WCAF200.7542794990.3659511711

[YHR196W][YHR196W]-0.3986777454

YPL217CBMS11.19647709280.3784366065

YOR277CYOR277C0.79117178870.3016752327

Telo genes up in dna2-1oc

YHR181W0.3-1.7777777778YHR181W0.3-1.7777777778

YHR186C--2.7037037037YHR186C--2.7037037037

RPL37A-1.6315789474-0.8518518519RPL37A-1.6315789474-0.8518518519

CRR1-0.98CRR1-0.98

YFR018C0.221.58YFR018C0.221.58

COX5B-0.441.08COX5B-0.441.08

QCR80.010.82QCR80.010.82

QCR90.610.76QCR90.610.76

QCR70.120.83QCR70.120.83

COX130.180.81COX130.180.81

QCR20.140.81QCR20.140.81

TFS10.873.8TFS10.873.8

RNR2-0.05263157890.93RNR2-0.05263157890.93

RNR40.211.13RNR40.211.13

YPR184W0.923.43YPR184W0.923.43

GPH1-1.94117647062.27GPH1-1.94117647062.27

MDH20.031.36MDH20.031.36

SOL40.022.79SOL40.022.79

GLK10.141.02GLK10.141.02

AMS12.532.14AMS12.532.14

PCK118.714.45PCK118.714.45

SED10.683.4SED10.683.4

YPS60.033.54YPS60.033.54

YMR250W-0.14942528741.7YMR250W-0.14942528741.7

YER053C-0.08695652171.31YER053C-0.08695652171.31

YFL066C1.551.71YFL066C1.551.71

HXK1-0.61290322581.16HXK1-0.61290322581.16

RNR2-0.05263157890.93RNR2-0.05263157890.93

RNR40.211.13RNR40.211.13

RAD513.642.07RAD513.642.07

PLM2-1.75PLM2-1.75

HSP123.115.15HSP123.115.15

HSP260.2918.68HSP260.2918.68

HSP30-0.75438596493.8HSP30-0.75438596493.8

HSP420.272.62HSP420.272.62

PIR31.448.29PIR31.448.29

CTT1-0.85185185191.74CTT1-0.85185185191.74

ALD3-0.05263157892.87ALD3-0.05263157892.87

ISF1-0.44927536231.04ISF1-0.44927536231.04

PUT10.523.69PUT10.523.69

CYC7-1.56410256412.41CYC7-1.56410256412.41

OM450.484.08OM450.484.08

SOL40.022.79SOL40.022.79

SSE2-0.09890109894.15SSE2-0.09890109894.15

HSP1040.22.31HSP1040.22.31

PGM2-1.08333333331.15PGM2-1.08333333331.15

GSY2-1.17391304351.01GSY2-1.17391304351.01

STF2-0.36986301371.04STF2-0.36986301371.04

SPI1-0.19047619050.95SPI1-0.19047619050.95

HSP780.491.78HSP780.491.78

SSA30.04-SSA30.04-

SSA41.153.42SSA41.153.42

YNL200C-0.02040816331YNL200C-0.02040816331

YLR297W0.351.26YLR297W0.351.26

YHL021C-0.12359550562.3YHL021C-0.12359550562.3

YJL161W-0.09890109891.5YJL161W-0.09890109891.5

YHR209W1.293.98YHR209W1.293.98

YDL204W1.088.86YDL204W1.088.86

YHR033W-0.81YHR033W-0.81

YLR149C-1.3809523810.94YLR149C-1.3809523810.94

YGR161C-0.08695652171.01YGR161C-0.08695652171.01

YLR327C-0.16279069770.78YLR327C-0.16279069770.78

YML128C1.14.37YML128C1.14.37

YGR043C1.026.73YGR043C1.026.73

YGL121C0.313.24YGL121C0.313.24

Telo genes down in dna2-1oc

RSPOA-2.0303030303-1.4390243902RSPOA-2.0303030303-1.4390243902

RPSOB-2.0303030303-1.5641025641RPSOB-2.0303030303-1.5641025641

ASC1-4.2631578947-2.2258064516ASC1-4.2631578947-2.2258064516

RPS14B-1.8571428571-1.2222222222RPS14B-1.8571428571-1.2222222222

RPS23B-0.6949152542-1.4390243902RPS23B-0.6949152542-1.4390243902

RPL16A-1.8571428571-1.9411764706RPL16A-1.8571428571-1.9411764706

RPL38-3.5454545455-1.7777777778RPL38-3.5454545455-1.7777777778

RPL36A-1.8571428571-1.1739130435RPL36A-1.8571428571-1.1739130435

RPL16B-2.5714285714-1.8571428571RPL16B-2.5714285714-1.8571428571

RPL18B-4.2631578947-1.3255813953RPL18B-4.2631578947-1.3255813953

RPL19B-1.4390243902-1.3255813953RPL19B-1.4390243902-1.3255813953

RPL23A-1.1276595745-1.1739130435RPL23A-1.1276595745-1.1739130435

RPL31A-2.7037037037-1.4390243902RPL31A-2.7037037037-1.4390243902

MRT4-0.3157894737-3.1666666667MRT4-0.3157894737-3.1666666667

YDL148C-0.5625-1.5YDL148C-0.5625-1.5

YFLO34C-A-2.8461538462-1.5641025641YFLO34C-A-2.8461538462-1.5641025641

RPL11A-1.5641025641-1.6315789474RPL11A-1.5641025641-1.6315789474

RPL21B-3-1.2727272727RPL21B-3-1.2727272727

RPL21A-3-1.5641025641RPL21A-3-1.5641025641

RPL33B-1-1.5641025641RPL33B-1-1.5641025641

RPL9B-4.5555555556-1.9411764706RPL9B-4.5555555556-1.9411764706

MRP4-0.1494252874-1.2222222222MRP4-0.1494252874-1.2222222222

RPS16B-2.4482758621-1.3255813953RPS16B-2.4482758621-1.3255813953

RPS17B-1.8571428571-1.2727272727RPS17B-1.8571428571-1.2727272727

RPS25B-2.0303030303-1.5641025641RPS25B-2.0303030303-1.5641025641

RPS27A-0.6393442623-1.5641025641RPS27A-0.6393442623-1.5641025641

RPS3-2.4482758621-1.9411764706RPS3-2.4482758621-1.9411764706

RPS1A-2.4482758621-1.380952381RPS1A-2.4482758621-1.380952381

RPS1B-2.5714285714-1.5641025641RPS1B-2.5714285714-1.5641025641

RPS4A-2.2258064516-1.1739130435RPS4A-2.2258064516-1.1739130435

RPS5-2.7037037037-1.2222222222RPS5-2.7037037037-1.2222222222

RPS6B-1.6315789474-1.8571428571RPS6B-1.6315789474-1.8571428571

MRPL20-0.1904761905-1.3255813953MRPL20-0.1904761905-1.3255813953

RPS7B-0.9607843137-1.5641025641RPS7B-0.9607843137-1.5641025641

YNL119W--4.2631578947YNL119W--4.2631578947

HTA10.71-1.7027027027HTA10.71-1.7027027027

HTA21.22-2.125HTA21.22-2.125

HTB11.33-1.1739130435HTB11.33-1.1739130435

HTB21.04-1.0833333333HTB21.04-1.0833333333

HHF11.97-1.7777777778HHF11.97-1.7777777778

HHF23.75-1.5HHF23.75-1.5

HHT11.34-0.3333333333HHT11.34-0.3333333333

HHT20.82-0.5151515152HHT20.82-0.5151515152

DNA damage repair pathway

DUN12.920.12DUN12.920.12

SRS2-0.67SRS2-0.67

HUG1-6.28HUG1-6.28

POL301.87-0.724137931POL301.87-0.724137931

RAD272.66-0.9230769231RAD272.66-0.9230769231

GRH1-0.44927536230.6GRH1-0.44927536230.6

RAD513.642.06RAD513.642.06

RAD521.030.38RAD521.030.38

RAD541.880RAD541.880

RAD591.17-0.2195121951RAD591.17-0.2195121951

RDH542.05-0.0309278351RDH542.05-0.0309278351

RHC181.57-0.3333333333RHC181.57-0.3333333333

SMC12.74-0.6949152542SMC12.74-0.6949152542

SMC31.4-1.0408163265SMC31.4-1.0408163265

CDC91.83-0.0526315789CDC91.83-0.0526315789

RAD16-0.33333333331.27RAD16-0.33333333331.27

SSL2-0.01010101011.74SSL2-0.01010101011.74

MSH20.88-0.3157894737MSH20.88-0.3157894737

MLH30.911.62MLH30.911.62

POL301.87-0.724137931POL301.87-0.724137931

DNA21.09-0.1363636364DNA21.09-0.1363636364

RNR2-0.05263157890.93RNR2-0.05263157890.93

RNR40.211.13RNR40.211.13

RAD513.642.06RAD513.642.06

RAD541.880RAD541.880

DUN12.920.12DUN12.920.12

PLM2-1.75PLM2-1.75

YER004W0.50.96YER004W0.50.96

YBR070C2.462.38YBR070C2.462.38

YBR070c2.4627717412.376809759

YER004W0.49755411970.9578341264

DNA damage signature genesDIN7-0.08067850.1666542224

WT oc/yc RT_PCRWT oc/yc microarrayPLM2-1.7498212616

YBR070c5.38963631863.462771741RNR40.206521491.1300275306

YER004W1.14515915211.4975541197RNR2-0.0472570.933981604

DIN71.29537488150.9253445868RAD541.88249647250.0048892888

PLM21.4930071981NARAD513.63784247572.06087936

RNR42.87673009041.20652149DUN12.9218685350.1228019748

RNR24.04025115750.9548754508RAD50--0.3799575

RAD542.0180812.8824964725RAD521.0280252810.378467103

RAD512.0172234.6378424757RAD513.6378424762.06087936

DUN14.00926576313.921868535RAD591.168308438-0.2153610007

RAD541.8824964730.004889289

dna2-1 oc/yc RT_PCRdna2-1 oc/yc microarrayRDH542.05-0.0309278351

YBR070c2.45391291643.376809759RHC181.574164909-0.3395885008

YER004W2.66272237571.9578341264SMC12.736948707-0.6855644995

DIN71.16951515261.1666542224SMC31.403216465-1.0526890001

PLM23.90198450772.7498212616

RNR43.80665014742.1300275306

RNR23.65953286851.933981604

RAD540.77439906731.0048892888

RAD513.07068570613.06087936

DUN12.86897120091.1228019748

Recomb genes RT-PCRdna2-1oc/yc RT-PCRdna2-1oc/yc microarray

CTS10.41384774490.1248138479

YMR118C5.45222178236.5979816774

RAD501.68359730490.7246599986

RAD521.04013068541.378467103

RAD513.07068570613.06087936

RAD591.24938254050.822800797

RAD540.77439906731.004889289

RDH541.6230242050.97

RHC180.94657138680.746497898

SMC10.49698724140.593273055

SMC30.49379295750.487165859

Wtoc/yc RT-PCRWtoc/yc microarray

RAD502.3613083952NA

RAD522.29809889772.028025281

RAD512.0172234.637842476

RAD593.06244582492.168308438

RAD542.0180812.882496473

RDH543.29187521513.05

RHC183.3667134182.574164909

SMC13.11041343.736948707

SMC32.61093232842.403216465

Sheet1

Gene name

Ratio of expression level OC/YC

Sheet2

Gene names

Ratio of expression level OC/YC

Sheet3

Gene names

Ratio of expression level OC/YC

Gene names

Ratio of expression level OC/YC

Gene names

Ratio of expression level OC/YC

Gene names

Ratio of expression level OC/YC

Chart11

2.920.12

00.67

06.28

1.87-0.724137931

2.66-0.9230769231

-0.44927536230.6

3.642.06

1.030.38

1.880

1.17-0.2195121951

2.05-0.0309278351

1.57-0.3333333333

2.74-0.6949152542

1.4-1.0408163265

1.83-0.0526315789

-0.33333333331.27

-0.01010101011.74

0.88-0.3157894737

0.911.62

1.87-0.724137931

1.09-0.1363636364

-0.05263157890.93

0.211.13

3.642.06

1.880

2.920.12

01.75

0.50.96

2.462.38

2.4627717412.376809759

0.49755411970.9578341264

-0.08067850.1666542224

01.7498212616

0.206521491.1300275306

-0.0472570.933981604

1.88249647250.0048892888

3.63784247572.06087936

2.9218685350.1228019748

0-0.3799575

1.0280252810.378467103

3.6378424762.06087936

1.168308438-0.2153610007

1.8824964730.004889289

2.05-0.0309278351

1.574164909-0.3395885008

2.736948707-0.6855644995

1.403216465-1.0526890001

Gene names

Ratio of expression level OC/YC

Sheet1

TCA cycleWT o/ydna2-1 o/yATTENTION: LES PLOTS SONT CENTRES SUR -1, +1

CIT35.364.31CIT35.364.31

IDP216.731.16IDP216.731.16

YJL200C1.05-0.75YJL200C1.05-0.75

YMR118C3.175.60YMR118C3.175.60

YJL045W0.002.33YJL045W0.002.33

SDH10.092.56SDH10.092.56

SDH20.300.81SDH20.300.81

SDH40.060.83SDH40.060.83

LSC20.191.14LSC20.191.14

oxydative phosphorylationCOX5B-0.441.08

COX5B-0.441.08QCR80.010.82

QCR80.010.82QCR90.610.76

QCR90.610.76QCR70.120.83

QCR70.120.83COX130.180.81

COX130.180.81QCR20.140.81

QCR20.140.81GSY1-3.99617792390.107666

GAC1-0.47561618041.027569

glycogen productionSGA1-3.497232

GSY1-3.99617792390.107666GLC3-1.5137533731

GAC1-0.47561618041.027569PCK118.7122024.448686

SGA1-3.497232FBP110.973538481.4415016212

GLC3-1.5137533731BIO20.9239281.044559

gluconeogenesisMLS14.360680.704805

PCK118.7122024.448686ACS12.36386602391.3610186379

FBP110.973538481.4415016212MDH20.0339551.359865

BIO20.9239281.044559POT12.3740181.595525

glyoxylate cycleACS12.3638661.361019

MLS14.360680.704805SPS191.2691042.603389

ACS12.36386602391.3610186379CAT23.9233076.396094

MDH20.0339551.359865OPI32.12806941811.5832917854

lipid metabolismOLE1-0.3018590.733216399

POT12.3740181.595525YAT23.66952597310.9815615696

ACS12.3638661.361019CHO11.49300400750.1415798781

SPS191.2691042.603389INO14.4278502999-0.002263

CAT23.9233076.396094HAP4-1.54920604980.157158

OPI32.12806941811.5832917854MLS14.360680.704805

OLE1-0.3018590.733216399

YAT23.66952597310.9815615696

CHO11.49300400750.1415798781

INO14.4278502999-0.002263

other Mig1p-repressed genes

HAP4-1.54920604980.157158

MLS14.360680.704805

GENES DOWNREGULATED IN ESR AND IN OLD WILD-TYPE CELLS

NameIDmean of the normalized ratios Wtoc/Wtycmean of the normalized ratios dna2-1oc/dna2-1ycRPL12A0.46381855790.6681434865RPL12A-1.1560155-0.4966845

YEL054CRPL12A0.46381855790.6681434865RPS22B0.36078433070.5066395108RPS22B-1.771739-0.97379

YLR367WRPS22B0.36078433070.5066395108RPL6A0.432705060.7404459336RPL6A-1.311043-0.3505375

YML073CRPL6A0.432705060.7404459336DED810.36211751110.6077420257DED81-1.7615345-0.645435

YHR019CDED810.36211751110.6077420257YDR365C0.46752676011.0095900963YDR365C-1.1389150.0095900963

YDR365CYDR365C0.46752676011.0095900963RPL35A0.45282841150.603816604RPL35A-1.208342-0.656132

YDL191WRPL35A0.45282841150.603816604RPL19A0.34160723130.5456795142RPL19A-1.9273385-0.8325775

YBR084C-ARPL19A0.34160723130.5456795142RPL8A0.39243379790.6005008778RPL8A-1.5482005-0.6652765

YHL033CRPL8A0.39243379790.6005008778RPL7A0.40287077660.5845924236RPL7A-1.4821855-0.7105935

YGL076CRPL7A0.40287077660.5845924236PDC50.44460351371.2790021737PDC5-1.2491950.2790021737

YLR134WPDC50.44460351371.2790021737RPL11B0.45830375360.4896429499RPL11B-1.181959-1.0423045

YGR085CRPL11B0.45830375360.4896429499RPS29A0.36855720540.5989083697RPS29A-1.713283-0.6697045

YLR388WRPS29A0.36855720540.5989083697RPS10A0.483379480.5895225339RPS10A-1.068768-0.696288

YOR293WRPS10A0.483379480.5895225339RPP2B0.48023439281.1733522321RPP2B-1.08231650.1733522321

YDR382WRPP2B0.48023439281.1733522321RPL100.40903969550.4940977553RPL10-1.4447505-1.023891

YLR075WRPL100.40903969550.4940977553RPL12B0.38254529960.6243658784RPL12B-1.6140695-0.601625

YDR418WRPL12B0.38254529960.6243658784CDC190.24768185270.9326696456CDC19-3.0374375-0.072191

YAL038WCDC190.24768185270.9326696456RPS150.44833871450.7981868388RPS15-1.2304565-0.2528395

YOL040CRPS150.44833871450.7981868388RPS11B0.35327949350.6230834343RPS11B-1.83062-0.6049215

YBR048WRPS11B0.35327949350.6230834343RPL2B0.34828327690.5971234771RPL2B-1.871226-0.6746955

YIL018WRPL2B0.34828327690.5971234771RPL20B0.40464115310.5591557419RPL20B-1.4713255-0.7884105

YOR312CRPL20B0.40464115310.5591557419RPL13A0.33461759570.5658049552RPL13A-1.988486-0.7673935

YDL082WRPL13A0.33461759570.5658049552RPL24B0.39794778330.5531539455RPL24B-1.5128925-0.807815

YGR148CRPL24B0.39794778330.5531539455RPL280.3487834520.5578791221RPL28-1.8671085-0.792503

YGL103WRPL280.3487834520.5578791221RPS25A0.31292939780.4897894811RPS25A-2.195609-1.0416935

YGR027CRPS25A0.31292939780.4897894811RPL42B0.36318555130.6388478252RPL42B-1.7534135-0.565318

YHR141CRPL42B0.36318555130.6388478252RPL43A0.36538409540.5941311723RPL43A-1.736846-0.68313

YPR043WRPL43A0.36538409540.5941311723RPL30.38861482910.821908801RPL3-1.573242-0.21668

YOR063WRPL30.38861482910.821908801GLN40.45338653670.5643836127GLN4-1.2056235-0.7718445

YOR168WGLN40.45338653670.5643836127RPL40B0.41415876280.4858155227RPL40B-1.414533-1.0583945

YKR094CRPL40B0.41415876280.4858155227YLR339C0.23482165650.7843912418YLR339C-3.258551-0.274874

YLR339CYLR339C0.23482165650.7843912418RPP2A0.36027149340.7667171167RPP2A-1.7756845-0.304262

YOL039WRPP2A0.36027149340.7667171167RPS24A0.42469436340.570001938RPS24A-1.3546345-0.75438

YER074WRPS24A0.42469436340.570001938RPS10B0.42130266360.5111719179RPS10B-1.3735905-0.956289

YMR230WRPS10B0.42130266360.5111719179RPS26B0.3018968633-RPS26B-2.3123895-

YER131WRPS26B0.3018968633-EGD20.42695649610.5707068718EGD2-1.342159-0.752213

YHR193CEGD20.42695649610.5707068718RPL17B0.37750714290.6468386891RPL17B-1.6489565-0.5459805

YJL177WRPL17B0.37750714290.6468386891STM10.34945674330.7258015934STM1-1.8615845-0.377787

YLR150WSTM10.34945674330.7258015934RPS9B0.33798262230.5220951994RPS9B-1.958732-0.9153595

YBR189WRPS9B0.33798262230.5220951994ARO40.44936165930.4864064003ARO4-1.225379-1.055894

YBR249CARO40.44936165930.4864064003RPS27B0.34831924640.5392139285RPS27B-1.8709295-0.8545515

YHR021CRPS27B0.34831924640.5392139285YJL188C0.29929447310.6688032702YJL188C-2.341191-0.495208

YJL188CYJL188C0.29929447310.6688032702RPS21A0.42583597990.5107027985RPS21A-1.348322-0.958086

YKR057WRPS21A0.42583597990.5107027985RPP1A0.46411476260.9272687484RPP1A-1.1546395-0.078436

YDL081CRPP1A0.46411476260.9272687484YPL142C0.46283911060.6331883121YPL142C-1.160578-0.579309

YPL142CYPL142C0.46283911060.6331883121RPS14A0.33448172060.5889264166RPS14A-1.9897-0.698005

YCR031CRPS14A0.33448172060.5889264166RPL24A0.41050793580.563356954RPL24A-1.4360065-0.7750735

YGL031CRPL24A0.41050793580.563356954RPL300.41145972950.6294068313RPL30-1.4303715-0.5887975

YGL030WRPL300.41145972950.6294068313YGR265W0.10571241340.9850901678YGR265W-8.459627-0.0151355

YGR265WYGR265W0.10571241340.9850901678YDR417C0.40814327460.5706130838YDR417C-1.45012-0.752501

YDR417CYDR417C0.40814327460.5706130838RPS21B0.34023378480.5556906192RPS21B-1.9391555-0.7995625

YJL136CRPS21B0.34023378480.5556906192RPL2A0.38461982250.5247696524RPL2A-1.59997-0.905598

YFR031C-ARPL2A0.38461982250.5247696524RPS120.45665989360.8022102497RPS12-1.1898135-0.246556

YOR369CRPS120.45665989360.8022102497RPS29B0.26133286290.7447777118RPS29B-2.8265375-0.3426825

YDL061CRPS29B0.26133286290.7447777118RPS130.36382098620.5280618677RPS13-1.7486045-0.8937175

YDR064WRPS130.36382098620.5280618677RPS8B0.30372445150.6296408466RPS8B-2.292458-0.588207

YER102WRPS8B0.30372445150.6296408466RPP00.24497009040.7037540351RPP0-3.082131-0.420951

YLR340WRPP00.24497009040.7037540351RPS26A0.33281447560.6463338651RPS26A-2.004677-0.547188

YGL189CRPS26A0.33281447560.6463338651RPL250.3924688370.5375270477RPL25-1.547973-0.8603715

YOL127WRPL250.3924688370.5375270477RPS8A0.34003126930.5689168847RPS8A-1.940906-0.757726

YBL072CRPS8A0.34003126930.5689168847RPL26A0.41698426970.5796886376RPL26A-1.398172-0.725064

YLR344WRPL26A0.41698426970.5796886376RPL13B0.27855657550.5454600001RPL13B-2.589935-0.833315

YMR142CRPL13B0.27855657550.5454600001RPL37A0.37791559520.5403503956RPL37A-1.6460935-0.850651

YLR185WRPL37A0.37791559520.5403503956RPL37B0.2754595940.5649805294RPL37B-2.6302965-0.7699725

YDR500CRPL37B0.2754595940.5649805294RPL7B0.37221441710.5670038355RPL7B-1.6866235-0.7636565

YPL198WRPL7B0.37221441710.5670038355RPL4A0.46074742910.5949553144RPL4A-1.1703865-0.6807985

YBR031WRPL4A0.46074742910.5949553144RPL6B0.34079823470.6719371174RPL6B-1.9342875-0.4882345

YLR448WRPL6B0.34079823470.6719371174RPS30B0.42335290850.5130529653RPS30B-1.3620955-0.9491165

YOR182CRPS30B0.42335290850.5130529653RPL22A0.28784855940.5174505007RPL22A-2.474049-0.932552

YLR061WRPL22A0.28784855940.5174505007YLL044W0.32132127310.7127444045YLL044W-2.11215-0.4030275

YLL044WYLL044W0.32132127310.7127444045RPL34B0.46201412280.7982311198RPL34B-1.164436-0.25277

YIL052CRPL34B0.46201412280.7982311198RPL42A0.35809718610.572882055RPL42A-1.792538-0.74556

YNL162WRPL42A0.35809718610.572882055RPL18A0.25026543780.5159780338RPL18A-2.9957575-0.938067

YOL120CRPL18A0.25026543780.5159780338YPR044C0.34501823850.6491032314YPR044C-1.8983975-0.540587

YPR044CYPR044C0.34501823850.6491032314SCP1600.38751849430.4656504776SCP160-1.580522-1.1475335

YJL080CSCP1600.38751849430.4656504776YLR062C0.23833490650.4780296383YLR062C-3.1957765-1.0919205

YLR062CYLR062C0.23833490650.4780296383RPS19A0.30538817740.5461562072RPS19A-2.274521-0.830978

YOL121CRPS19A0.30538817740.5461562072RPS22A0.45271279090.4775283515RPS22A-1.208906-1.0941165

YJL190CRPS22A0.45271279090.4775283515RPL17A0.28175323770.6660909421RPL17A-2.549205-0.5012965

YKL180WRPL17A0.28175323770.6660909421YKL078W0.44935156320.4799694355YKL078W-1.225429-1.083466

YKL078WYKL078W0.44935156320.4799694355RPS11A0.35645153210.5287611707RPS11A-1.8054305-0.891213

YDR025WRPS11A0.35645153210.5287611707RPL320.47004795660.6205134935RPL32-1.1274425-0.6115685

YBL092WRPL320.47004795660.6205134935RPL390.23068934130.4926875317RPL39-3.334834-1.029684

YJL189WRPL390.23068934130.4926875317RPL8B0.27496280780.6754550118RPL8B-2.6368555-0.4804835

YLL045CRPL8B0.27496280780.6754550118

YGR272C0.96670241850.1844707028YGR272C-0.0344445-4.420915

SUP450.92720942420.3701665731SUP45-0.078505-1.7014865

YOL022C0.56466597040.3846910652YOL022C-0.7709585-1.5994885

DPH50.57495931440.4216610663DPH5-0.7392535-1.371573

CCT51.57659699420.447670357CCT50.5765969942-1.2337865

YOL041C0.79821455370.3808158675YOL041C-0.252796-1.625941

GENES DOWNREGULATED IN ESR AND THE OLD DNA2-1 CELLSYOL077C1.07174760770.3225194185YOL077C0.0717476077-2.1005885

NameIDmean of the normalized ratios Wtoc/Wtycmean of the normalized ratios dna2-1oc/dna2-1ycNUC10.94425050590.4255178819NUC1-0.059041-1.3500775

YGR272CYGR272C0.96670241850.1844707028CCT30.88624119410.4606038609CCT3-0.128361-1.171063

YBR143CSUP450.92720942420.3701665731YBR061C1.26398440750.3649390634YBR061C0.2639844075-1.7401835

YOL022CYOL022C0.56466597040.3846910652YGL099W0.80626175130.2983079081YGL099W-0.240292-2.352241

YLR172CDPH50.57495931440.4216610663YNL163C1.14873274680.4397707563YNL163C0.1487327468-1.273912

YJR064WCCT51.57659699420.447670357GCN30.50025775780.4240686075GCN3-0.9989695-1.358109

YOL041CYOL041C0.79821455370.3808158675YGR103W0.86332525260.4146597996YGR103W-0.158312-1.4116155

YOL077CYOL077C1.07174760770.3225194185MRT40.75652979780.2414037629MRT4-0.321825-3.1424375

YJL208CNUC10.94425050590.4255178819SSF21.29974700420.4546036231SSF20.2997470042-1.1997185

YJL014WCCT30.88624119410.4606038609KAP1231.4695195920.2573593515KAP1230.469519592-2.8856175

YBR061CYBR061C1.26398440750.3649390634NMD31.07427540120.337233893NMD30.0742754012-1.965301

YGL099WYGL099W0.80626175130.2983079081SPB11.70865545050.455779893SPB10.7086554505-1.1940415

YNL163CYNL163C1.14873274680.4397707563YGR145W0.90966772110.3531022326YGR145W-0.0993025-1.832041

YKR026CGCN30.50025775780.4240686075YGR200C1.04500578670.3066011848YGR200C0.0450057867-2.261566

YGR103WYGR103W0.86332525260.4146597996RPA340.88975372950.334836414RPA34-0.1239065-1.986533

YKL009WMRT40.75652979780.2414037629YMR212C0.94753633450.308514475YMR212C-0.0553685-2.241339

YDR312WSSF21.29974700420.4546036231YJR041C0.60079148270.2964951897YJR041C-0.664471-2.372736

YER110CKAP1231.4695195920.2573593515PMA10.63417190940.4166697049PMA1-0.5768595-1.3999825

YHR170WNMD31.07427540120.337233893YMR131C0.58875097070.4041645111YMR131C-0.698511-1.47424

YCL054WSPB11.70865545050.455779893YCR072C1.04605136530.3550308673YCR072C0.0460513653-1.8166565

YGR145WYGR145W0.90966772110.3531022326YOR206W0.55686418640.3354410773YOR206W-0.79577-1.9811495

YGR200CYGR200C1.04500578670.3066011848YOL124C1.49594337560.0570120162YOL124C0.4959433756-16.540162

YJL148WRPA340.88975372950.334836414NPT10.58572511740.4463947929NPT1-0.7072855-1.2401695

YMR212CYMR212C0.94753633450.308514475YDR091C0.67721909460.2283965421YDR091C-0.476627-3.37835

YJR041CYJR041C0.60079148270.2964951897YCL045C1.02239609770.4618201718YCL045C0.0223960977-1.165345

YGL008CPMA10.63417190940.4166697049YMR215W0.89991828740.3248912508YMR215W-0.111212-2.077953

YMR131CYMR131C0.58875097070.4041645111YDR412W1.04437497030.4559256659YDR412W0.0443749703-1.19334

YCR072CYCR072C1.04605136530.3550308673LOS11.4277107230.2314138786LOS10.427710723-3.321262

YOR206WYOR206W0.55686418640.3354410773CGR10.81173673920.2652866103CGR1-0.2319265-2.769508

YOL124CYOL124C1.49594337560.0570120162YGR245C1.09195816490.4471185112YGR245C0.0919581649-1.2365435

YOR209CNPT10.58572511740.4463947929YNR054C0.78063067930.3890389823YNR054C-0.2810155-1.5704365

YDR091CYDR091C0.67721909460.2283965421FRS10.65472684960.3732383616FRS1-0.5273545-1.679253

YCL045CYCL045C1.02239609770.4618201718YLR221C0.58837079250.3632818666YLR221C-0.6996085-1.7526835

YMR215WYMR215W0.89991828740.3248912508YPR144C0.65436653880.3980563704YPR144C-0.5281955-1.512207

YDR412WYDR412W1.04437497030.4559256659YNL132W0.80190725620.2612505253YNL132W-0.247027-2.8277435

YKL205WLOS11.4277107230.2314138786YLR222C0.65859167410.2192087834YLR222C-0.5183915-3.561861

YGL029WCGR10.81173673920.2652866103MTR40.81625889770.2210969615MTR4-0.2251015-3.5229025

YGR245CYGR245C1.09195816490.4471185112ASN10.70120547740.3587456816ASN1-0.4261155-1.78749

YNR054CYNR054C0.78063067930.3890389823RPS27A0.61010821180.3862730904RPS27A-0.6390535-1.588842

YLR060WFRS10.65472684960.3732383616ECM11.68836924640.4631809368ECM10.6883692464-1.1589835

YLR221CYLR221C0.58837079250.3632818666HAS11.16808306470.2432379249HAS10.1680830647-3.111201

YPR144CYPR144C0.65436653880.3980563704YJR070C0.7518115840.1988727099YJR070C-0.3301205-4.028342

YNL132WYNL132W0.80190725620.2612505253YDL201W1.12540753820.4573871803YDL201W0.1254075382-1.1863315

YLR222CYLR222C0.65859167410.2192087834TYS10.73439151810.3350546206TYS1-0.3616715-1.984588

YJL050WMTR40.81625889770.2210969615YJR071W0.7246933460.3721135847YJR071W-0.379894-1.6873515

YPR145WASN10.70120547740.3587456816CBF50.83383363350.4553598242CBF5-0.19928-1.1960655

YKL156WRPS27A0.61010821180.3862730904CDC600.51532711680.3680974369CDC60-0.940515-1.716672

YAL059WECM11.68836924640.4631809368YPL226W1.75126747980.349686541YPL226W0.7512674798-1.859704

YMR290CHAS11.16808306470.2432379249DCD10.76229709080.4140185865DCD1-0.3118245-1.4153505

YJR070CYJR070C0.7518115840.1988727099POL320.71117761410.4475258088POL32-0.4061185-1.234508

YDL201WYDL201W1.12540753820.4573871803YLR002C0.96327652730.3962527958YLR002C-0.0381235-1.5236415

YGR185CTYS10.73439151810.3350546206YOR287C1.27943827540.4645391702YOR287C0.2794382754-1.152671

YJR071WYJR071W0.7246933460.3721135847HGH10.58343601810.3230397263HGH1-0.713984-2.0955945

YLR175WCBF50.83383363350.4553598242YNL247W0.69265484560.2833399777YNL247W-0.4437205-2.529329

YPL160WCDC600.51532711680.3680974369HIS60.61521405910.4313027456HIS6-0.6254505-1.318557

YPL226WYPL226W1.75126747980.349686541IMP41.12551647140.4458744132IMP40.1255164714-1.242784

YHR144CDCD10.76229709080.4140185865RPB101.23512980910.4183451896RPB100.2351298091-1.3903705

YJR043CPOL320.71117761410.4475258088YDR398W0.76205456010.4566846068YDR398W-0.312242-1.189695

YLR002CYLR002C0.96327652730.3962527958YNL182C1.12749295740.3570583746YNL182C0.1274929574-1.8006625

YOR287CYOR287C1.27943827540.4645391702RPA490.65755233380.2127795391RPA49-0.5207915-3.6997

YGR187CHGH10.58343601810.3230397263ZUO10.50269317870.4411050829ZUO1-0.989285-1.2670335

YNL247WYNL247W0.69265484560.2833399777IMP30.77462543960.398749124IMP3-0.2909465-1.5078425

YIL020CHIS60.61521405910.4313027456RPA1351.0516701310.252228979RPA1350.051670131-2.9646515

YNL075WIMP41.12551647140.4458744132YDR496C0.56427644810.278592118YDR496C-0.772181-2.589477

YOR210WRPB101.23512980910.4183451896GCD110.97035798930.3833370293GCD11-0.0305475-1.6086705

YDR398WYDR398W0.76205456010.4566846068YNL174W0.64477837520.4256886045YNL174W-0.5509205-1.349135

YNL182CYNL182C1.12749295740.3570583746YNL175C0.99853465040.3417220399YNL175C-0.0014675-1.926355

YNL248CRPA490.65755233380.2127795391YLR003C1.64557993120.3409175557YLR003C0.6455799312-1.9332605

YGR285CZUO10.50269317870.4411050829NOP580.48972699680.3294367554NOP58-1.041954-2.035484

YHR148WIMP30.77462543960.398749124YDR324C1.01754916160.2325746091YDR324C0.0175491616-3.2996955

YPR010CRPA1351.0516701310.252228979RLP70.71758970230.3276201297RLP7-0.393554-2.0523155

YDR496CYDR496C0.56427644810.278592118RPO261.1601789460.4270595159RPO260.160178946-1.341594

YER025WGCD110.97035798930.3833370293MPP100.68386495860.3473883776MPP10-0.462277-1.8786225

YNL174WYNL174W0.64477837520.4256886045PPT10.81905515440.321377656PPT1-0.220919-2.111604

YNL175CYNL175C0.99853465040.3417220399ECM160.94445562050.3309508184ECM16-0.058811-2.021597

YLR003CYLR003C1.64557993120.3409175557YJR003C0.65660787180.2591908425YJR003C-0.522979-2.858161

YOR310CNOP580.48972699680.3294367554YDR165W-0.2351247725YDR165W--3.253061

YDR324CYDR324C1.01754916160.2325746091KRR10.99836467870.3627501321KRR1-0.001638-1.7567185

YNL002CRLP70.71758970230.3276201297YHR088W0.9913578380.4571994976YHR088W-0.0087175-1.187229

YPR187WRPO261.1601789460.4270595159FEN11.11590703160.3552508924FEN10.1159070316-1.814912

YJR002WMPP100.68386495860.3473883776GAR10.77140672960.4160313521GAR1-0.296333-1.403665

YGR123CPPT10.81905515440.321377656DIM11.18784384370.3967979989DIM10.1878438437-1.520174

YMR128WECM160.94445562050.3309508184YHR197W0.67767619410.1382840881YHR197W-0.475631-6.23149

YJR003CYJR003C0.65660787180.2591908425RPC400.69840986040.3090215281RPC40-0.431824-2.2360205

[YDR165W][YDR165W]-0.2351247725YDR190C0.9846784040.4339558285YDR190C-0.01556-1.304382

YCL059CKRR10.99836467870.3627501321YDR101C1.08512949390.3277332998YDR101C0.0851294939-2.0512615

YHR088WYHR088W0.9913578380.4571994976YNL114C1.46693169230.390742757YNL114C0.4669316923-1.5592285

YCR034WFEN11.11590703160.3552508924ARO71.07869396050.4152248848ARO70.0786939605-1.4083335

YHR089CGAR10.77140672960.4160313521THR10.58927918490.3012555427THR1-0.6969885-2.319441

YPL266WDIM11.18784384370.3967979989YNL010W0.56576238040.3854510722YNL010W-0.7675265-1.594363

YHR197WYHR197W0.67767619410.1382840881TIF46310.81461749640.3197126678TIF4631-0.22757-2.1278085

YPR110CRPC400.69840986040.3090215281ASN20.79567819430.4384914841ASN2-0.2567895-1.280546

YDR190CYDR190C0.9846784040.4339558285ROK10.68708193210.3637790312ROK1-0.4554305-1.7489215

YDR101CYDR101C1.08512949390.3277332998YOR169C0.65863852170.4489452704YOR169C-0.5182835-1.227443

YNL114CYNL114C1.46693169230.390742757NOP40.97021865330.2875169761NOP4-0.0306955-2.4780555

YPR060CARO71.07869396050.4152248848VAS10.50546023420.3801097681VAS1-0.978395-1.630819

YHR025WTHR10.58927918490.3012555427SSH10.7750156650.3815305633SSH1-0.2902965-1.621022

YNL010WYNL010W0.56576238040.3854510722PWP10.65094059290.3503646157PWP1-0.5362385-1.8541695

YGR162WTIF46310.81461749640.3197126678MIS10.66475748320.3878677301MIS1-0.504308-1.5781985

YGR124WASN20.79567819430.4384914841DBP30.7686253290.3828049381DBP3-0.301024-1.6122965

YGL171WROK10.68708193210.3637790312YPL044C0.63713868660.3609613773YPL044C-0.569517-1.7703795

YOR169CYOR169C0.65863852170.4489452704HCA40.81234537510.3862872656HCA4-0.2310035-1.588747

YPL043WNOP40.97021865330.2875169761YHR052W0.61575274080.2707336272YHR052W-0.6240285-2.6936675

YGR094WVAS10.50546023420.3801097681YML093W1.0082301830.3495363837YML093W0.008230183-1.8609325

YBR283CSSH10.7750156650.3815305633ARO20.68913024530.3574191549ARO2-0.4511045-1.7978355

YLR196WPWP10.65094059290.3503646157AAH10.51661525050.2388892034AAH1-0.9356765-3.186041

YBR084WMIS10.66475748320.3878677301PRT10.62680814560.4122668348PRT1-0.5953845-1.4256135

YGL078CDBP30.7686253290.3828049381YNL119W-0.1902636931YNL119W--4.2558635

YPL044CYPL044C0.63713868660.3609613773YNR053C0.89350134140.4217461598YNR053C-0.1191925-1.3710945

YJL033WHCA40.81234537510.3862872656YOR243C0.5364945020.281327664YOR243C-0.863952-2.554574

YHR052WYHR052W0.61575274080.2707336272MES10.72980421910.2305783562MES1-0.3702305-3.3369205

YML093WYML093W1.0082301830.3495363837SUB20.72639708860.4272753803SUB2-0.3766575-1.340411

YGL148WARO20.68913024530.3574191549NCL10.67911391930.2760242189NCL1-0.472507-2.6228705

YNL141WAAH10.51661525050.2388892034TIF30.91689199290.3358033911TIF3-0.090641-1.977933

YOR361CPRT10.62680814560.4122668348RPG10.51272795890.4035051687RPG1-0.950352-1.478283

[YNL119W][YNL119W]-0.1902636931FUR11.00563406480.371268841FUR10.0056340648-1.693466

YNR053CYNR053C0.89350134140.4217461598MAK160.98494899440.3425153126MAK16-0.015281-1.9195775

YOR243CYOR243C0.5364945020.281327664RMT20.78935382710.3814740922RMT2-0.266859-1.62141

YGR264CMES10.72980421910.2305783562PRO10.85961831230.3847590033PRO1-0.163307-1.5990295

YDL084WSUB20.72639708860.4272753803RRP30.72299809960.3718319453RRP3-0.3831295-1.689387

YBL024WNCL10.67911391930.2760242189APT11.07177287850.3354244814APT10.0717728785-1.981297

YPR163CTIF30.91689199290.3358033911YLR243W0.92758441250.4579786289YLR243W-0.078069-1.183508

YBR079CRPG10.51272795890.4035051687TIF20.50255612610.408261498TIF2-0.9898275-1.4494105

YHR128WFUR11.00563406480.371268841YER006W0.94876345290.3595918058YER006W-0.0540035-1.780931

YAL025CMAK160.98494899440.3425153126YDL060W0.8641892090.4553968396YDL060W-0.157154-1.195887

YDR465CRMT20.78935382710.3814740922SSF10.93995828470.3955303488SSF1-0.063877-1.528251

YDR300CPRO10.85961831230.3847590033YER126C0.89429400180.2840661744YER126C-0.1182005-2.5203065

YHR065CRRP30.72299809960.3718319453URA70.99592219660.4130278909URA7-0.0040945-1.421144

YML022WAPT11.07177287850.3354244814YDL062W0.71809624070.4615398817YDL062W-0.392571-1.16666

YLR243WYLR243W0.92758441250.4579786289ELP30.71406894340.3028071892ELP3-0.400425-2.3024315

YJL138CTIF20.50255612610.408261498YVH11.09947560510.4149371567YVH10.0994756051-1.4100035

YER006WYER006W0.94876345290.3595918058DBP90.50946963960.2851711569DBP9-0.9628255-2.506666

YDL060WYDL060W0.8641892090.4553968396SIK10.61920175610.2503058111SIK1-0.6149825-2.995113

YHR066WSSF10.93995828470.3955303488YPL183C0.91133278770.2370534446YPL183C-0.097294-3.218458

YER126CYER126C0.89429400180.2840661744RPB50.95276750380.4241945288RPB5-0.049574-1.357409

YBL039CURA70.99592219660.4130278909YLR409C0.84196310430.3012440173YLR409C-0.1877005-2.319568

YDL062WYDL062W0.71809624070.4615398817GIS20.72321169640.4627682147GIS2-0.382721-1.160909

YPL086CELP30.71406894340.3028071892RPS7B0.51082671690.3878880408RPS7B-0.957611-1.5780635

YIR026CYVH11.09947560510.4149371567YNR024W0.64944996460.3999007446YNR024W-0.5397645-1.5006205

YLR276CDBP90.50946963960.2851711569ARD10.71741646850.4075238687ARD1-0.3938905-1.453844

YLR197WSIK10.61920175610.2503058111YGR128C1.25383438230.2396678874YGR128C0.2538343823-3.1724405

YPL183CYPL183C0.91133278770.2370534446YMR049C0.88866652480.279499729YMR049C-0.1252815-2.577821

YBR154CRPB50.95276750380.4241945288SUI20.85368846770.4409428681SUI2-0.1713875-1.2678675

YLR409CYLR409C0.84196310430.3012440173SAH11.21831690740.457607682SAH10.2183169074-1.185278

YNL255CGIS20.72321169640.4627682147YML060W-0.275036769YML060W--2.6358775

YNL096CRPS7B0.51082671690.3878880408YLR186W0.82114447010.4580328542YLR186W-0.2178125-1.1832495

YNR024WYNR024W0.64944996460.3999007446DBP81.42085214190.406268974DBP80.4208521419-1.4614235

YHR013CARD10.71741646850.4075238687YDR341C0.5674864860.2337617134YDR341C-0.7621565-3.2778605

YGR128CYGR128C1.25383438230.2396678874LCP50.75504321680.4306138918LCP5-0.3244275-1.322266

YMR049CYMR049C0.88866652480.279499729YFR001W0.87216312590.3954064056YFR001W-0.1465745-1.5290435

YJR007WSUI20.85368846770.4409428681YBL028C1.45985508020.277389548YBL028C0.4598550802-2.6050385

YER043CSAH11.21831690740.457607682RRP10.98200379840.3857651874RRP1-0.018326-1.5922505

[YML060W][YML060W]-0.275036769RPL33B0.50391034430.3860864482RPL33B-0.98448-1.5900935

YLR186WYLR186W0.82114447010.4580328542YBL077W0.51101688530.2928543252YBL077W-0.9568825-2.414667

YHR169WDBP81.42085214190.406268974YLR198C0.6570822460.2585397957YLR198C-0.5218795-2.8678765

YDR341CYDR341C0.5674864860.2337617134SKI80.78099678620.3559698728SKI8-0.280415-1.8092265

YER127WLCP50.75504321680.4306138918RRP51.0625372220.2221922016RRP50.062537222-3.500608

YFR001WYFR001W0.87216312590.3954064056GAS11.48463660920.4012092447GAS10.4846366092-1.492465

YBL028CYBL028C1.45985508020.277389548YDL167C-0.4273510666YDL167C--1.3399965

YDR087CRRP10.98200379840.3857651874YNL022C0.76524326320.4484456761YNL022C-0.306774-1.2299245

YOR234CRPL33B0.50391034430.3860864482MAK110.84254480550.4298763181MAK11-0.1868805-1.3262505

YBL077WYBL077W0.51101688530.2928543252NIP10.50138092840.3484537279NIP1-0.9944915-1.8698215

YLR198CYLR198C0.6570822460.2585397957YMR093W0.67363724030.4184138933YMR093W-0.4844785-1.389978

YGL213CSKI80.78099678620.3559698728YER049W1.29092390130.4240927067YER049W0.2909239013-1.357975

YMR229CRRP51.0625372220.2221922016VMA60.50049073120.4199620564VMA6-0.998039-1.3811675

YMR307WGAS11.48463660920.4012092447PUS40.85884127710.4111022267PUS4-0.1643595-1.432485

[YDL167C][YDL167C]-0.4273510666YOR252W1.23290576160.3264600436YOR252W0.2329057616-2.063162

YNL022CYNL022C0.76524326320.4484456761YNL120C0.55104069550.4092299357YNL120C-0.814748-1.443614

YKL021CMAK110.84254480550.4298763181YLR076C0.49079056050.4440852288YLR076C-1.037529-1.25182

YMR309CNIP10.50138092840.3484537279YKR081C1.40446380730.3917634861YKR081C0.4044638073-1.5525605

YMR093WYMR093W0.67363724030.4184138933YNL110C0.73667755480.403991517YNL110C-0.357446-1.4752995

YER049WYER049W1.29092390130.4240927067SUR40.98133645270.4484696087SUR4-0.0190185-1.2298055

YLR447CVMA60.50049073120.4199620564YCR057C-0.3029879765YCR057C--2.300461

YNL292WPUS40.85884127710.4111022267RPS23B0.59289844040.4140941928RPS23B-0.6866295-1.4149095

YOR252WYOR252W1.23290576160.3264600436TIF51.60201597690.4151034562TIF50.6020159769-1.409038

YNL120CYNL120C0.55104069550.4092299357YOR271C1.21266727990.3830972146YOR271C0.2126672799-1.6103035

YLR076CYLR076C0.49079056050.4440852288YLL034C-0.3524720362YLL034C--1.8371045

YKR081CYKR081C1.40446380730.3917634861NIP71.37474335260.2594323439NIP70.3747433526-2.8545695

YNL110CYNL110C0.73667755480.403991517PUS11.15787176220.2802894044PUS10.1578717622-2.567741

YLR372WSUR40.98133645270.4484696087YTM10.90027435860.4320445732YTM1-0.1107725-1.314576

[YCR057C][YCR057C]-0.3029879765YOR004W0.76779705590.3689862619YOR004W-0.3024275-1.710128

YPR132WRPS23B0.59289844040.4140941928YGR173W0.98811690610.4400172839YGR173W-0.012026-1.272638

YPR041WTIF51.60201597690.4151034562RPB90.72095428390.3597741554RPB9-0.3870505-1.7795215

YOR271CYOR271C1.21266727990.3830972146FUN111.33136114370.2950556202FUN110.3313611437-2.3891915

[YLL034C][YLL034C]-0.3524720362YDR339C0.57642170090.4257006554YDR339C-0.734841-1.3490685

YPL211WNIP71.37474335260.2594323439WRS10.66943702020.230126055WRS1-0.4937925-3.3454445

YPL212CPUS11.15787176220.2802894044RRP90.73956346530.457312507RRP9-0.352149-1.1866885

YOR272WYTM10.90027435860.4320445732YER070W-0.1536412673YER070W--5.508668

YOR004WYOR004W0.76779705590.3689862619YJL109C-0.0206896241YJL109C--47.333406

YGR173WYGR173W0.98811690610.4400172839DBP100.8766001240.3222362162DBP10-0.140771-2.1033135

YGL070CRPB90.72095428390.3597741554CAF200.7542794990.3659511711CAF20-0.3257685-1.732605

YAL036CFUN111.33136114370.2950556202YHR196W-0.3986777454YHR196W--1.5082915

YDR339CYDR339C0.57642170090.4257006554BMS11.19647709280.3784366065BMS10.1964770928-1.6424505

YOL097CWRS10.66943702020.230126055YOR277C0.79117178870.3016752327YOR277C-0.263948-2.314823

YPR137WRRP90.73956346530.457312507

[YER070W][YER070W]-0.1536412673

[YJL109C][YJL109C]-0.0206896241

YDL031WDBP100.8766001240.3222362162

YOR276WCAF200.7542794990.3659511711

[YHR196W][YHR196W]-0.3986777454

YPL217CBMS11.19647709280.3784366065

YOR277CYOR277C0.79117178870.3016752327

Telo genes up in dna2-1oc

YHR181W0.3-1.7777777778YHR181W0.3-1.7777777778

YHR186C--2.7037037037YHR186C--2.7037037037

RPL37A-1.6315789474-0.8518518519RPL37A-1.6315789474-0.8518518519

CRR1-0.98CRR1-0.98

YFR018C0.221.58YFR018C0.221.58

COX5B-0.441.08COX5B-0.441.08

QCR80.010.82QCR80.010.82

QCR90.610.76QCR90.610.76

QCR70.120.83QCR70.120.83

COX130.180.81COX130.180.81

QCR20.140.81QCR20.140.81

TFS10.873.8TFS10.873.8

RNR2-0.05263157890.93RNR2-0.05263157890.93

RNR40.211.13RNR40.211.13

YPR184W0.923.43YPR184W0.923.43

GPH1-1.94117647062.27GPH1-1.94117647062.27

MDH20.031.36MDH20.031.36

SOL40.022.79SOL40.022.79

GLK10.141.02GLK10.141.02

AMS12.532.14AMS12.532.14

PCK118.714.45PCK118.714.45

SED10.683.4SED10.683.4

YPS60.033.54YPS60.033.54

YMR250W-0.14942528741.7YMR250W-0.14942528741.7

YER053C-0.08695652171.31YER053C-0.08695652171.31

YFL066C1.551.71YFL066C1.551.71

HXK1-0.61290322581.16HXK1-0.61290322581.16

RNR2-0.05263157890.93RNR2-0.05263157890.93

RNR40.211.13RNR40.211.13

RAD513.642.07RAD513.642.07

PLM2-1.75PLM2-1.75

HSP123.115.15HSP123.115.15

HSP260.2918.68HSP260.2918.68

HSP30-0.75438596493.8HSP30-0.75438596493.8

HSP420.272.62HSP420.272.62

PIR31.448.29PIR31.448.29

CTT1-0.85185185191.74CTT1-0.85185185191.74

ALD3-0.05263157892.87ALD3-0.05263157892.87

ISF1-0.44927536231.04ISF1-0.44927536231.04

PUT10.523.69PUT10.523.69

CYC7-1.56410256412.41CYC7-1.56410256412.41

OM450.484.08OM450.484.08

SOL40.022.79SOL40.022.79

SSE2-0.09890109894.15SSE2-0.09890109894.15

HSP1040.22.31HSP1040.22.31

PGM2-1.08333333331.15PGM2-1.08333333331.15

GSY2-1.17391304351.01GSY2-1.17391304351.01

STF2-0.36986301371.04STF2-0.36986301371.04

SPI1-0.19047619050.95SPI1-0.19047619050.95

HSP780.491.78HSP780.491.78

SSA30.04-SSA30.04-

SSA41.153.42SSA41.153.42

YNL200C-0.02040816331YNL200C-0.02040816331

YLR297W0.351.26YLR297W0.351.26

YHL021C-0.12359550562.3YHL021C-0.12359550562.3

YJL161W-0.09890109891.5YJL161W-0.09890109891.5

YHR209W1.293.98YHR209W1.293.98

YDL204W1.088.86YDL204W1.088.86

YHR033W-0.81YHR033W-0.81

YLR149C-1.3809523810.94YLR149C-1.3809523810.94

YGR161C-0.08695652171.01YGR161C-0.08695652171.01

YLR327C-0.16279069770.78YLR327C-0.16279069770.78

YML128C1.14.37YML128C1.14.37

YGR043C1.026.73YGR043C1.026.73

YGL121C0.313.24YGL121C0.313.24

Telo genes down in dna2-1oc

RSPOA-2.0303030303-1.4390243902RSPOA-2.0303030303-1.4390243902

RPSOB-2.0303030303-1.5641025641RPSOB-2.0303030303-1.5641025641

ASC1-4.2631578947-2.2258064516ASC1-4.2631578947-2.2258064516

RPS14B-1.8571428571-1.2222222222RPS14B-1.8571428571-1.2222222222

RPS23B-0.6949152542-1.4390243902RPS23B-0.6949152542-1.4390243902

RPL16A-1.8571428571-1.9411764706RPL16A-1.8571428571-1.9411764706

RPL38-3.5454545455-1.7777777778RPL38-3.5454545455-1.7777777778

RPL36A-1.8571428571-1.1739130435RPL36A-1.8571428571-1.1739130435

RPL16B-2.5714285714-1.8571428571RPL16B-2.5714285714-1.8571428571

RPL18B-4.2631578947-1.3255813953RPL18B-4.2631578947-1.3255813953

RPL19B-1.4390243902-1.3255813953RPL19B-1.4390243902-1.3255813953

RPL23A-1.1276595745-1.1739130435RPL23A-1.1276595745-1.1739130435

RPL31A-2.7037037037-1.4390243902RPL31A-2.7037037037-1.4390243902

MRT4-0.3157894737-3.1666666667MRT4-0.3157894737-3.1666666667

YDL148C-0.5625-1.5YDL148C-0.5625-1.5

YFLO34C-A-2.8461538462-1.5641025641YFLO34C-A-2.8461538462-1.5641025641

RPL11A-1.5641025641-1.6315789474RPL11A-1.5641025641-1.6315789474

RPL21B-3-1.2727272727RPL21B-3-1.2727272727

RPL21A-3-1.5641025641RPL21A-3-1.5641025641

RPL33B-1-1.5641025641RPL33B-1-1.5641025641

RPL9B-4.5555555556-1.9411764706RPL9B-4.5555555556-1.9411764706

MRP4-0.1494252874-1.2222222222MRP4-0.1494252874-1.2222222222

RPS16B-2.4482758621-1.3255813953RPS16B-2.4482758621-1.3255813953

RPS17B-1.8571428571-1.2727272727RPS17B-1.8571428571-1.2727272727

RPS25B-2.0303030303-1.5641025641RPS25B-2.0303030303-1.5641025641

RPS27A-0.6393442623-1.5641025641RPS27A-0.6393442623-1.5641025641

RPS3-2.4482758621-1.9411764706RPS3-2.4482758621-1.9411764706

RPS1A-2.4482758621-1.380952381RPS1A-2.4482758621-1.380952381

RPS1B-2.5714285714-1.5641025641RPS1B-2.5714285714-1.5641025641

RPS4A-2.2258064516-1.1739130435RPS4A-2.2258064516-1.1739130435

RPS5-2.7037037037-1.2222222222RPS5-2.7037037037-1.2222222222

RPS6B-1.6315789474-1.8571428571RPS6B-1.6315789474-1.8571428571

MRPL20-0.1904761905-1.3255813953MRPL20-0.1904761905-1.3255813953

RPS7B-0.9607843137-1.5641025641RPS7B-0.9607843137-1.5641025641

YNL119W--4.2631578947YNL119W--4.2631578947

HTA10.71-1.7027027027HTA10.71-1.7027027027

HTA21.22-2.125HTA21.22-2.125

HTB11.33-1.1739130435HTB11.33-1.1739130435

HTB21.04-1.0833333333HTB21.04-1.0833333333

HHF11.97-1.7777777778HHF11.97-1.7777777778

HHF23.75-1.5HHF23.75-1.5

HHT11.34-0.3333333333HHT11.34-0.3333333333

HHT20.82-0.5151515152HHT20.82-0.5151515152

DNA damage repair pathway

DUN12.920.12DUN12.920.12

SRS2-0.67SRS2-0.67

HUG1-6.28HUG1-6.28

POL301.87-0.724137931POL301.87-0.724137931

RAD272.66-0.9230769231RAD272.66-0.9230769231

GRH1-0.44927536230.6GRH1-0.44927536230.6

RAD513.642.06RAD513.642.06

RAD521.030.38RAD521.030.38

RAD541.880RAD541.880

RAD591.17-0.2195121951RAD591.17-0.2195121951

RDH542.05-0.0309278351RDH542.05-0.0309278351

RHC181.57-0.3333333333RHC181.57-0.3333333333

SMC12.74-0.6949152542SMC12.74-0.6949152542

SMC31.4-1.0408163265SMC31.4-1.0408163265

CDC91.83-0.0526315789CDC91.83-0.0526315789

RAD16-0.33333333331.27RAD16-0.33333333331.27

SSL2-0.01010101011.74SSL2-0.01010101011.74

MSH20.88-0.3157894737MSH20.88-0.3157894737

MLH30.911.62MLH30.911.62

POL301.87-0.724137931POL301.87-0.724137931

DNA21.09-0.1363636364DNA21.09-0.1363636364

RNR2-0.05263157890.93RNR2-0.05263157890.93

RNR40.211.13RNR40.211.13

RAD513.642.06RAD513.642.06

RAD541.880RAD541.880

DUN12.920.12DUN12.920.12

PLM2-1.75PLM2-1.75

YER004W0.50.96YER004W0.50.96

YBR070C2.462.38YBR070C2.462.38

YBR070c2.4627717412.376809759

YER004W0.49755411970.9578341264

DNA damage signature genesDIN7-0.08067850.1666542224

WT oc/yc RT_PCRWT oc/yc microarrayPLM2-1.7498212616

YBR070c5.38963631863.462771741RNR40.206521491.1300275306

YER004W1.14515915211.4975541197RNR2-0.0472570.933981604

DIN71.29537488150.9253445868RAD541.88249647250.0048892888

PLM21.4930071981NARAD513.63784247572.06087936

RNR42.87673009041.20652149DUN12.9218685350.1228019748

RNR24.04025115750.9548754508RAD50--0.3799575

RAD542.0180812.8824964725RAD521.0280252810.378467103

RAD512.0172234.6378424757RAD513.6378424762.06087936

DUN14.00926576313.921868535RAD591.168308438-0.2153610007

RAD541.8824964730.004889289

dna2-1 oc/yc RT_PCRdna2-1 oc/yc microarrayRDH542.05-0.0309278351

YBR070c2.45391291643.376809759RHC181.574164909-0.3395885008

YER004W2.66272237571.9578341264SMC12.736948707-0.6855644995

DIN71.16951515261.1666542224SMC31.403216465-1.0526890001

PLM23.90198450772.7498212616

RNR43.80665014742.1300275306

RNR23.65953286851.933981604

RAD540.77439906731.0048892888

RAD513.07068570613.06087936

DUN12.86897120091.1228019748

Recomb genes RT-PCRdna2-1oc/yc RT-PCRdna2-1oc/yc microarray

CTS10.41384774490.1248138479

YMR118C5.45222178236.5979816774

RAD501.68359730490.7246599986

RAD521.04013068541.378467103

RAD513.07068570613.06087936

RAD591.24938254050.822800797

RAD540.77439906731.004889289

RDH541.6230242050.97

RHC180.94657138680.746497898

SMC10.49698724140.593273055

SMC30.49379295750.487165859

Wtoc/yc RT-PCRWtoc/yc microarray

RAD502.3613083952NA

RAD522.29809889772.028025281

RAD512.0172234.637842476

RAD593.06244582492.168308438

RAD542.0180812.882496473

RDH543.29187521513.05

RHC183.3667134182.574164909

SMC13.11041343.736948707

SMC32.61093232842.403216465

Sheet1

Gene name

Ratio of expression level OC/YC

Sheet2

Gene names

Ratio of expression level OC/YC

Sheet3

Gene names

Ratio of expression level OC/YC

Gene names

Ratio of expression level OC/YC

Gene names

Ratio of expression level OC/YC

Gene names

Ratio of expression level OC/YC

Result summaryMetabolic ResponseEnergyESR16/48

Chart10

2.920.12

00.67

06.28

1.87-0.724137931

2.66-0.9230769231

-0.44927536230.6

3.642.06

1.030.38

1.880

1.17-0.2195121951

2.05-0.0309278351

1.57-0.3333333333

2.74-0.6949152542

1.4-1.0408163265

1.83-0.0526315789

-0.33333333331.27

-0.01010101011.74

0.88-0.3157894737

0.911.62

1.87-0.724137931

1.09-0.1363636364

-0.05263157890.93

0.211.13

3.642.06

1.880

2.920.12

01.75

0.50.96

2.462.38

2.4627717412.376809759

0.49755411970.9578341264

-0.08067850.1666542224

01.7498212616

0.206521491.1300275306

-0.0472570.933981604

1.88249647250.0048892888

3.63784247572.06087936

2.9218685350.1228019748

0-0.3799575

1.0280252810.378467103

3.6378424762.06087936

1.168308438-0.2153610007

1.8824964730.004889289

2.05-0.0309278351

1.574164909-0.3395885008

2.736948707-0.6855644995

1.403216465-1.0526890001

Gene names

Ratio of expression level OC/YC

Sheet1

TCA cycleWT o/ydna2-1 o/yATTENTION: LES PLOTS SONT CENTRES SUR -1, +1

CIT35.364.31CIT35.364.31

IDP216.731.16IDP216.731.16

YJL200C1.05-0.75YJL200C1.05-0.75

YMR118C3.175.60YMR118C3.175.60

YJL045W0.002.33YJL045W0.002.33

SDH10.092.56SDH10.092.56

SDH20.300.81SDH20.300.81

SDH40.060.83SDH40.060.83

LSC20.191.14LSC20.191.14

oxydative phosphorylationCOX5B-0.441.08

COX5B-0.441.08QCR80.010.82

QCR80.010.82QCR90.610.76

QCR90.610.76QCR70.120.83

QCR70.120.83COX130.180.81

COX130.180.81QCR20.140.81

QCR20.140.81GSY1-3.99617792390.107666

GAC1-0.47561618041.027569

glycogen productionSGA1-3.497232

GSY1-3.99617792390.107666GLC3-1.5137533731

GAC1-0.47561618041.027569PCK118.7122024.448686

SGA1-3.497232FBP110.973538481.4415016212

GLC3-1.5137533731BIO20.9239281.044559

gluconeogenesisMLS14.360680.704805

PCK118.7122024.448686ACS12.36386602391.3610186379

FBP110.973538481.4415016212MDH20.0339551.359865

BIO20.9239281.044559POT12.3740181.595525

glyoxylate cycleACS12.3638661.361019

MLS14.360680.704805SPS191.2691042.603389

ACS12.36386602391.3610186379CAT23.9233076.396094

MDH20.0339551.359865OPI32.12806941811.5832917854

lipid metabolismOLE1-0.3018590.733216399

POT12.3740181.595525YAT23.66952597310.9815615696

ACS12.3638661.361019CHO11.49300400750.1415798781

SPS191.2691042.603389INO14.4278502999-0.002263

CAT23.9233076.396094HAP4-1.54920604980.157158

OPI32.12806941811.5832917854MLS14.360680.704805

OLE1-0.3018590.733216399

YAT23.66952597310.9815615696

CHO11.49300400750.1415798781

INO14.4278502999-0.002263

other Mig1p-repressed genes

HAP4-1.54920604980.157158

MLS14.360680.704805

GENES DOWNREGULATED IN ESR AND IN OLD WILD-TYPE CELLS

NameIDmean of the normalized ratios Wtoc/Wtycmean of the normalized ratios dna2-1oc/dna2-1ycRPL12A0.46381855790.6681434865RPL12A-1.1560155-0.4966845

YEL054CRPL12A0.46381855790.6681434865RPS22B0.36078433070.5066395108RPS22B-1.771739-0.97379

YLR367WRPS22B0.36078433070.5066395108RPL6A0.432705060.7404459336RPL6A-1.311043-0.3505375

YML073CRPL6A0.432705060.7404459336DED810.36211751110.6077420257DED81-1.7615345-0.645435

YHR019CDED810.36211751110.6077420257YDR365C0.46752676011.0095900963YDR365C-1.1389150.0095900963

YDR365CYDR365C0.46752676011.0095900963RPL35A0.45282841150.603816604RPL35A-1.208342-0.656132

YDL191WRPL35A0.45282841150.603816604RPL19A0.34160723130.5456795142RPL19A-1.9273385-0.8325775

YBR084C-ARPL19A0.34160723130.5456795142RPL8A0.39243379790.6005008778RPL8A-1.5482005-0.6652765

YHL033CRPL8A0.39243379790.6005008778RPL7A0.40287077660.5845924236RPL7A-1.4821855-0.7105935

YGL076CRPL7A0.40287077660.5845924236PDC50.44460351371.2790021737PDC5-1.2491950.2790021737

YLR134WPDC50.44460351371.2790021737RPL11B0.45830375360.4896429499RPL11B-1.181959-1.0423045

YGR085CRPL11B0.45830375360.4896429499RPS29A0.36855720540.5989083697RPS29A-1.713283-0.6697045

YLR388WRPS29A0.36855720540.5989083697RPS10A0.483379480.5895225339RPS10A-1.068768-0.696288

YOR293WRPS10A0.483379480.5895225339RPP2B0.48023439281.1733522321RPP2B-1.08231650.1733522321

YDR382WRPP2B0.48023439281.1733522321RPL100.40903969550.4940977553RPL10-1.4447505-1.023891

YLR075WRPL100.40903969550.4940977553RPL12B0.38254529960.6243658784RPL12B-1.6140695-0.601625

YDR418WRPL12B0.38254529960.6243658784CDC190.2476