- 1. Isaac Karimi Assistant Professor College of Veterinary
Medicine Razi University Tel: +98(831)8322599-8329540 Fax:
+98(831)8320041 Email: [email protected];
[email protected] Homepage:
http://www.razi.ac.ir/isaac_karimi Personal Data: Nationalities:
Iranian Birth: 1979 Gender: Male Marital status: Married Persian:
Mother language
2. English: Good Turkish: Fair Arabic: Good Place of birth: Iran
Education: College of Veterinary Medicine in Shahr-e-kord
University Doctor of Veterinary Medicine (DVM) (1998-2004) College
of Veterinary Medicine in Urmia University Doctor of Veterinary
Sciences (DVSc): Expert of Physiology (2004-2008) Research
Activities: Theses: DVM: The assessment of the efficacy of
progesterone during day's 3-5 post insemination on pregnancy rate
in dairy cows. DVSc (Ph.D.): Effects of Cannabis sativa L. seed on
serum lipids, lipoproteins and apolipoproteins of Wistar rats. 3.
Teaching: 1. Medical Terminology in Shahrekord University (2000) 2.
Biochemistry courses through the "Classmate Programme" in
Shahrekord University (2000) 3. English courses in Kish Institute
of Urmia (2005) 4. Physiology courses for veterinary and nurse
students in Urmia Islamic Azad University (2006) 5. Physiology
courses for veterinary student in College of veterinary medicine,
Razi University 6. Biochemistry courses for veterinary student in
College of veterinary medicine, Razi University 7. Hematology
courses for veterinary student in College of veterinary medicine,
Razi University 8. Laboratory animal medicine for veterinary
student in College of veterinary medicine, Razi University
Technical Skills: 4. 1. Setting up of enzymology lab in Artemia and
Aquatic Animals Research Institute, Urmia University 2. Setting up
of behavior (psychopharmacology) lab in Physiology Department of
Veterinary College of Urmia University 3. Preparing of Animal and
Surgery House in Bioscience and Biotechnology Research Center of
Urmia University 4. Setting up of the rumen protistology in College
of Veterinary Medicine, Razi University, Kermanshah, Iran. 5.
Setting up of nutritional neuroscience lab in in College of
Veterinary Medicine, Razi University, Kermanshah, Iran. 6. I am
familiar with Electrophoresis, HPLC, TLC, GC, PCR, Western
Blotting, Enzyme kinetics, Laboratory and farm animal surgery, and
ICV. 7. I am familiar with all in vivo electrophysiology such as
field potential, unicellular and patch clamp recordings.
Membership: 1. Member of Iranian Philosophy and Theosophy Society
2. Member of International Endocannabinoid Research Society 5. 3.
Member of SciLink group: http://www.scilink.com 4. Member of World
Veterinary Association 5. Member of Iranian Society of Physiology
and Pharmacology 6. Member of Advisory Board of EuroMDnet:
http://www.euromdnet.org Invited lecture: 1. What are the major
pathways of xenobiotic metabolism in our body (Shahrekord Uni) 2.
Crimean-Congo hemorrhagic fever outbreak during wool trimming in
sheep (Shahrekord Uni) 3. Biochemical principles of fluid therapy
in animals (Shahrekord Uni) 4. Role of endocannabinoid system in
diabesity and plurimetabolic syndrome (Urmia Uni) 5. From cannabis
to cannabinergic system: Developmental biology (Urmia Uni) 6.
Interaction of endocannabinoid and histaminergic systems in memory
and learning (Urmia Uni) 6. 7. Marijuana and emesis: New generation
of antiemetics in chemotherapy-induced emesis (Urmia Uni) 8.
Xenoestrogens act as endocrine disruptors (Urmia Uni) 9. Nocebo and
placebo neuroendocrinology (Urmia Uni) 10.Anti-inflammatory drugs:
friend or foe (Urmia Uni) 11.Addiction and plasticity:
Psychobiological approach (Urmia Uni) 12.Orthodox versus
Traditional medicine in diabesity (Urmia Uni) 13.Review of
G-proteins, G-protein coupled receptors and their signaling (Ahvaz
Uni) 14.Endocannabinoid system in veterinary medicine: past,
present and future (Tabriz Uni) 15.The role of Tachykinins as old
neurotransmitters from frog to human (Urmia Uni) 16.Endocannabinoid
system as an emerging target of pharmacotherapy (Razi Uni)
17.Nootropics in Traditional and Orthodox Medicines: Minireview
(Razi Uni) Publications: 7. 1. Karimi, I and H Hayatghaibi, 2006.
Effect of Cannabis sativa L. seed (hempseed) on lipid and protein
profiles of rat. Paki. J. Nutr., 5(6):585-588. 2. Hayatghaybi, H
and I Karimi, 2007. Hypercholesterolemic effect of drug-type
Cannabis sativa L. seed (marijuana seed) in guinea pig. Paki. J.
Nutr. 6(1):56-59. 3. Karimi, I, Hayatghaibi, H,Yousofi J,
Saberivand A, Zavareh S, 2007. Effects of nondrug type Cannabis
sativa L. (hempseed) on hematological parameters in guinea pig. J.
Cardiova. Hemato. Dis -Drug Targets. 7(4):288-290. 4. Karimi, I,
Yousofi M and H Hayatghaibi, 2007. Effects of isfahanian variety of
Cannabis sativa L.) on lipoprotein profile of male rats. Iran. J.
Endocri. Metabol., 9(4):423-427. 5. A. Moghaddam, I. Karimi and M.
Pooyanmehr (2009). Effects of short-term cooling on pregnancy rate
of dairy heifers under summer heat stress. Veterinary Research
Communications. 33(6):567-575. 8. 6. J. Talebi, M. Souri, A.
Moghaddam, I. Karimi (2009). Characteristics and seasonal variation
in the semen of Markhoz goat bucks in western Iran. Small Ruminant
Research 85(1). 18- 22. 7. Chalechaleh A, Bahiraei A, I. Karimi
(2009). Slaughter-based survey of gastrointestinal helminth
parasite infestation in sheep in Kermanshah district. Pazhohesh va
Sazandegi Journal (submitted). 8. Adel Saberivand, Isaac Karimi,
Lora A. Becker, Saeed Azizi- Mahmoodjigh, Aliasghar Moghaddan,
Msume Yousofi, Saeed Zavareh (2009). The effects of hempseed on the
ovariectomized rat model of menopause. Methods Find Exp Clin
Pharmacol (under review). 9. Chalechale A, Karimi I. (2010).
Retrospective study of the prevalence of Trichomonas vaginalis
infection among women of Kermanshah district, Iran during
2006-2007. Turkish journal of medical sciences (in press) 9.
10.Isaac Karimi, Farzaneh Noori, Naser Agh, Aliasghar Moghaddam,
Abdolali Chalechale, Msume Yousefi, Amir Dadyan (2010).
Distribution of lipase activity in tissues of rainbow trout
(Oncorhynchus mykiss). Journal of Applied Biological Sciences (in
press). 11.Hayatgheybi H, Karimi I, Dadyan A, Hadipour MM (2010).
Anti- hyperlipidaemic effects of an essential oil of Melissa
officinalis. L in cholesterol-fed rabbits. Journal of Applied
Biological Sciences (in press). 12.Karimi, I, Yousefi J,
Ghashghaeii A, 2010. Ocular toxicity caused by euphorbia sap. Iran.
J. Pharma. Therapeutics. (in press). 13.Karimi I, Yousofi M,
Saberivand, A. Becker L, Moghaddam A (2010) The effects of Cannabis
sativa L. seed (hemp seed) on reproductive and neurobehavioral end
points in rats. Developmental Psychobiology Journal (under review).
14. Ali Mikaeili, Isaac Karimi, Tanaz Bakhtiari (2010). The
preliminary study on the contamination of warehouse-stored 10.
pistachios to aflatoxinogenic fungi in Kermanshah, Iran: the tip of
the iceberg. Turkish Journal of Biology (submitted). 15.Isaac
Karimi, Behruz Sohrabi, Abdolali Chalechale, Aliasghar Moghaddam,
Hussein Mohammadi, Amir Dadyan, Reza Ali Rahmati Asl, Msume
Yousefi. Effects of tail shaving on milk quality and udder
cleanliness in a dairy farm. Journal of Animal and Veterinary
Advances (submitted). 16.I. Karimi, A. Chalechale, A. Bahiraie
& M. Azadbakht: Larvae of Taenia taeniaeformis in the
hepatobiliary system of Mus musculus. The Internet Journal of
Parasitic Diseases. 2009 Volume 4 Number 1. Abstracts: 1. Emadi A,
Yekta M, I Karimi. Serological evaluation of avian influenza in
broilers of Chahar Mahal Province of Iran. The First Scientific
Seminar of Veterinary Medical Students of Islamic Azad University,
Iran, May 2001(in Persian) 11. 2. Shahbazkia H, I Karimi. The role
of leptin in metabolic and reproductive controls in livestock. The
1st Congress (Manuscript in Preparation) of Iranian Veterinary
Laboratory Science Student, Iran, 24-26 Jul.2004 (in Persian) 3.
Hayatghaibi H, Karimi I, Yousefy M, Yousefi J and H Islami. Effects
of hempseed powder (Isfahanian variety) on serum lipid profile of
male rat. 2nd International Conference of Biology, Iran, August
2006. 4. Karimi I, Hayatghaybi H, Aminkhah S, A Abdolazimzadeh.
Effects of hempseed powder (Khorasan variety) on serum lipid
profile of female rat. 14th national Conference of biology, Iran,
August 2006 (in Persian). 5. Abdolazimzadeh A, Hayatghaybi H,
Karimi I, S Aminkhah. Hempseed and serum protein profile of rat.
14th national Conference of biology, Iran, August 2006. (in
Persian) 6. Karimi I, Zavareh S, Pourtaheri SH, M Pak. Effect of
oxytocin on learning and memory in object recognition task in
female rats. 12. The 5th Veterinary Clinical Congress, Ahvaz, Feb
2007 (in Persian) 7. Hayatgheybi H, Karimi I, M Yousofi. Fatty acid
content of Cannabis sativa L. seed (hemp seed) cultivated in
Khorasan province of Iran: Friend or Foe. The 9th Congress of
Iranian Biochemistry & the 2nd International Congress of
Biochemistry and Molecular Biology, Shiraz. Iran, Oct 29, Nov, 1,
2007. 8. Karimi I, Hayatgheybi H, Yousofi M, Islami I, Bakhtyarkia
S, D Naseri. Does preoperative nutrition alter anesthesia profile?
An involvement of marijuana seed in guinea pigs. 2nd International
Symposium of Veterinary Surgery (ISVS) & 7th Iranian Symposium
of Veterinary Surgery Anesthesia and Radiology (ISVSAR), April,
21-24, 2008, Kerman, IRAN. 9. Karimi I, M.R. Shoelepash, M.
Yousofi, N. Agh. (2009). Characterization of fatty acid composition
of black cumin (Nigella sativa L.) seed cultivated in Southern
Khorasan province of Iran: friend or foe. 1st International
Congress of Food Hygiene; Tehran, Iran; 25-26. 13. 10. Karimi I,
M.R. Shoelepash, M. Yousofi, (2009). The role of drought on
possible epizootic outbreak of metabolic diseases and preventive
strategies against it. National Exhibition of Bovine Nutrition and
Metabolic Diseases, Birjand, Southern Khorasan province of Iran (in
Persian). 11. Karimi I, A Dadian, A Moghaddam, A Chalechale, M
Yousofi, M Rahmatiasl (2009). Effect of tail shaving on milk
quality and subclinical mastitis. High productive dairy cattle
symposium, Shiraz University (in Persian) 12. Zakari I, S. Azizi
Mahmoodjigh, I. Karimi (2009). Effect of the omentoplasty on
psychophysiological recovery after experimental sciatic nerve crush
injury in rats: verifying of novel in vivo rapid test. 19th Iranian
Congress of Physiology & Pharmacology, Tehran, Iran 13.
Chalechale A, Karimi I (2009). Antiparasitic remedies in Kurdish
ethnopharmacology: a neglected treasure trove. 5th International
Joint Conference of Agricultural Sciences, Saint Petersburg, 8-9
October 2009, Russia (accepted orally) 14. 14. Karimi* I, Zavarreh
S, Becker L, Saberivand A, Azizi- Mahmoodjigh S (2009). The effects
of hempseed on metabolic and psychophysiologic profiles of
ovariectomized rat model of menopause. The 8th International
Congress of Endocrine Disorders together with the 2nd Arab &
Iranian Congress of Endocrinology and Diabetes and the 2nd Iranian
Congress on Prevention and Management of Obesity (accepted orally)
15. Ranjbar F, Karimi I (2010). Pharmacognosy of anticonvulsant and
antiepileptic remedies in Kurdish ethnomedicine: Minireview. The
First Scientific Seminar of Application of Medicinal Plants, Ahvaz
University, Iran. Code:8811 (in Persian: poster) 16. Moatamedi S,
Karimi I (2010). Ethnopharmacological survey of analgesic and
anti-inflammatory remedies in Isfahan, Iran. The First Scientific
Seminar of Application of Medicinal Plants, Ahvaz University, Iran.
Code:8648 (in Persian: oral) 17. Fathi M, Karimi I, Amirian M,
Olfati S (2010). Phytochemical aanalysis of Oak as a functional
food in Kurdish ethnomedicine. 15. The First Scientific Seminar of
Application of Medicinal Plants, Ahvaz University, Iran. Code: 1464
(in Persian: poster) 18. Isaac Karimi, Azadeh Karimi, Msume Yousefi
(2010). Reference intervals of serum lipid profile and atherogenic
index of sampled population in Kermanshah, Iran. 19. Isaac Karimi,
Seyed Hassan Pourtaheri (2010). Hempseed is an adoptogen! 17th
International Congress of Neurology & Clinical
Electrophisiology of Iran (accepted). 20. Isaac Karimi, Seyed
Hassan Pourtaheri, Msume Yousofi, Ali Jalili, Maziar Fathi (2010).
Maternal intake of hempseed as a junk nut did not alter stress,
depression, and psychomotor profiles in rat offspring at
post-weaning. 15th seminar of Iranian pharmacy students, Kerman,
Iran (submitted) 21. Isaac Karimi, Aliasghar Moghaddam, Sirous
Bahadori, Daryoush Komazani (2010). Effect of in ovo injection
royal jelly on hatchability outcomes in broiler chickens. EAAP,
Greece (accepted) 16. 22. Aliasghar Moghaddam, Isaac Karimi, Sirous
Bahadori, Daryoush Komazani (2010). Effect of Royal Jelly Injection
in Hy-line Eggs on Embryonic Growth, Hatchability and Gonadotropin
Level of Chicks: Double-sided sword. EAAP, Greece (accepted) 23.
Abdolali Chalechale, Isaac Karimi (2010). Larvae of Taenia
taeniaeformis in the hepatobiliary system of Mus musculus in
Kermanshah province, Iran: The tip of the iceberg! Manuscript in
preparation: 1. Karimi I, Hayatghaibi H, Malekineghad H, Yousofi M.
The effects of Cannabis sativa L. on lipid, lipoprotein,
apolipoprotein and antioxidant profiles of mature rats. In prep -
to be submitted to Nutrition Journal. 2. Saberivand A, Karimi I,
Azizi MJS, Yousofi M, Zavareh S. The effects of black seed (Nigella
sativa L.) on hormonal profile and spermatogenesis in juvenile
rats. In prep - to be submitted to Andrology. 17. 3. Moghaddam A,
Karimi I. The steroid hormone profile of Markhoz doe throughout
estrous cycle and gestation period. In prep - to be submitted to
Animal Reproduction Journal. 4. Chalechale A, Karimi I. Monthly
variation of Giardiasis in Kermanshah district, Iran during
2006-2007: A retrospective study. In prep - to be submitted to Open
journal of parasitology. 5. Hussein Hayatgheybi, Isaac Karimi. Dose
and time-dependent hyperlipidemic effect of Salix aegyptiaca in
cholesterol-fed rabbits. Student's theses and projects 1.
Ethnopharmacology and Ethnomedicine of Ghasr-e-Shirin district,
Kermanshah, Iran. MS project 2. Antiparasitic remedies in Kurdish
ethnopharmacology: a neglected treasure trove 3. The application of
geographical information system (GIS) and spatial analysis in
veterinary science. 18. 4. An attempt to revive and document
Iranian ethnoveterinary medicine: From shepherds mind to neglected
textbooks. 5. The comparison of nutrient values of hempseed and oak
fruit as two popular nuts among Kurdish tribes in Kermanshah: food
chemical analysis 6. Reference interval of bilirubin level in
inhabitants of Kermanshah province of Iran. 7. Reference interval
of lipid profile in inhabitants of Kermanshah province of Iran. 8.
Roles of probiotics in normal and abnormal physiology. 9.
Craniomorphological, craniomorphometrical and stereotoxic studies
of the skulls of two Iran native sheep breeds: Sanjabi vs. Mehraban
10. What is oxidative stress? 11. The effects of hempseed oil on
CCl-4 induced hepatotoxicity in male adult rats. 12. The effects of
pomegranate on CCl-4 and paracetamol-induced hepatotoxicity in male
adult rats. 19. 13. Evaluation of decoction of Astragalus verus
Olivier. against clinical isolates of Trichophyton verrucosum: in
vitro and in guinea pig 14. The effects of pomegranate on
cyclophosphamide-induced testicular toxicity: Biochemical and
psychological investigation. 15. Is Tharkhina as a traditional food
in Kurdistan ethnomedicine, a functional food?
Immunopsychophysiological view. 16. The effects of aerial parts of
Astragalus verrus against Candidia albicans both in vitro and in
guinea pig model of candidiasis 17. The measurement of reference
intervals of lipid and lipoprotein profiles and its association
with morphometric indices in Kalkohi sheep 18. Reference interval
of lipid profile in Markhoz goat, an indigenous Iranian breed. 19.
Craniomorphological study of the skulls of Iranian water buffalo
20. The biolochemical and psychopharmacological effects of
Aquilaria sinensis in rats 20. 21. Neuroeconomics of food hoarding
in rats after several psychophysiological stresses. 22. The
psychophysiology and lipid profile of handicapped rats 23. Dose and
time-dependent hyperlipidemic effect of Salix aegyptiaca in normal
rabbits. 24. Effect of Alfalfa Extract (Polysavone) on Lead
Toxicity in Broiler Chickens Recent activities: 1. Dysregulation of
the endocrine system can occur in various ways and physiologically
during aging. The human ovaries become unresponsive to
gonadotropins with advancing age, and their function declines, so
that sexual cycles disappear (menopause). I and our colleagues; Dr
Saberivand (Molecular Theriogenologist), Dr Zavareh (Veterinary
Theriogenologist) and Dr Azizi (Animal Surgeon) were motivated to
evaluate the effect of phytoesterogens and high fat diets on
ovariectomized rats: animal model of 21. menopause. We hypothesized
that feeding ovariectomized rat with high- fat diet and nuts that
contain phytoestrogen would increase circulating 17 beta estradiol
(E2) levels. The oil contained in hempseed is 75-80%
polyunsaturated fatty acids: PUFAs. Arachidonic acid (a metabolite
of n-6 PUFA) also can increase aromatization of androstenedione to
estrone via prostaglandin E2-induced activation of P450 aromatase.
Recently our team concentrated to compare the effects of soybean
and hempseed in preventing of metabolic and psychic symptoms of
menopause. 2. The supply of polyunsaturated fatty acids (PUFAs) is
important for optimal fetal and postnatal development. In the
present project, I and my coworkers: Drs Saberivand and Yousofi
evaluate the effect of maternal dietary intake of hempseed, the
rich source of (n-3), (n-6) PUFA and phytoestrogen, on the leptin
content in rat milk, serum leptin levels in suckling pups, sex
ratio, postnatal physiological growth indices in pups,
neurobehavioral and reproductive end points, mammary gland
development, puberty 22. onset, immunotoxicity tests and breast
cancer risk among female rat offspring. 3. Larvae of marine fish
are very immature at hatching and undergo major developmental
changes over several weeks. In particular, the switch from
endogenous to exogenous feeding is concomitant with morphology and
functionality transformations of the digestive tract. The influence
of diet on enzymatic regulation during postnatal development has
been widely demonstrated for many species. I and my coworker Dr
Noori (Fish physiologist) were setting up enzymological assay for
digestive enzymes such as trypsin, chymotrypsin, lipase, amylase,
and the chief hormone CCK in the GI system of salmon and other
Persian varieties of fish following different diet formulae. Our
goal is to introduce the most suitable diets for different stages
of growth of aforementioned fish. 4. The rumen is populated with
many types of micro-organisms, which degrade and ferment the feed
eaten by the animal. However, from a production point of view, not
all the micro- 23. organisms present in the rumen are essential or
provide efficient conversion of feed to protein1. Many studies have
shown that if protozoa are removed from the rumen, a process known
as defaunation, wool growth can be increased due to increased
microbial protein outflow to the small intestine. However,
successful defaunation methods can be laborious and impractical in
normal animal husbandry settings and chemical-based methods can be
detrimental to animal health. I and my colleague; Dr Abdolali
Chalechale (Parasitologist), in collaboration with the most
prominent scientist Prof Dehority from Ohio university were
motivated to characterize fauna of protozoa in Iranian breeds of
sheep and goats because we sense their meager in current literature
of protistology. 5. My special interest is studying in the field of
translational physiology. The theme of translational physiology is
defined as the interacting contributions of clinical and laboratory
research in advancing the understanding of normal and pathological
physiology. The idea is to take a research program from bench to
24. bedside, an area that is receiving increasing support. This
area enable us to produce animal models for human and animal
diseases such as menopause, diabetes mellitus, hypertension,
metabolic syndrome, obesity, MS, epilepsy, addiction and knockout
animals. I have produced four animal models: Andropause, Menopause,
DM and Diet-induced obesity in Urmia University successfully.
Honors: 1. Ranked 1th and being top student in all high school
classes. 2. Ranked 2th in the Nationwide Preclinical Veterinary
Basic Science Examination of Iran. Veterinary Faculties among 300
participants, 2000. 3. Ranked 1th in Residency of Veterinary
Physiology in all terms, 2003-07. 4. Ranked 1th in the Nationwide
Board Physiology Examination of Iran Universities among all
participants, Tehran 2007. 25. 5. Ranked 1th in the score of thesis
in Urmia University, 2008 (19.92 out of 20).
