IPTC2016 Programme (2016-09-22)...entry, and translocation in the body (including dosimetry) Wolfgang Kreyling, Helmholtz Zentrum München, German Research Center for Environmental

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ContentsContentsContentsContents Programme in a nutshellProgramme in a nutshellProgramme in a nutshellProgramme in a nutshell ........................................................................................................................................................................................................................................................................................................................................................................ 2222

Monday, 26 September 2016Monday, 26 September 2016Monday, 26 September 2016Monday, 26 September 2016 ........................................................................................................................................................................................................................................................................................................................................ 4444

Opening session: The big picture – setting the stage ..................................................................... 4 Control and characterisation of exposure, routes of entry, and translocation in the body ........... 4 Particles for diagnosis and therapy ................................................................................................ 5 Technical challenges in particle toxicology .................................................................................... 5 Special A*STAR session: “Particle toxicity testing in the 21st century” ......................................... 7

Tuesday, 27 September 2016Tuesday, 27 September 2016Tuesday, 27 September 2016Tuesday, 27 September 2016 ........................................................................................................................................................................................................................................................................................................................................ 9999

Particle sources and properties linked to toxicology ..................................................................... 9 Immunity and systemic responses ............................................................................................... 10 Non-specific effects of particles ................................................................................................... 10 Particles and the developing body ............................................................................................... 12 Raising to the challenge of complex nanomaterials in EHS .......................................................... 12 Poster session .............................................................................................................................. 14 Dinner banquet ............................................................................................................................ 14

Wednesday 28 September 2016Wednesday 28 September 2016Wednesday 28 September 2016Wednesday 28 September 2016 ................................................................................................................................................................................................................................................................................................................ 15151515

Bioavailability, biopersistence, bioprocessing, biomodification, and bioclearance ..................... 15 Lessons from fibrous and mineral particles for nanoparticle risk management and governance 15 Particles from forest & coal fires and other incidental sources ................................................... 17 Special Symposium: Airborne ultra-fine particles and environmental public health implications

in Singapore – toxicology, exposure, mitigation .......................................................................... 19

Thursday 29 September 2016Thursday 29 September 2016Thursday 29 September 2016Thursday 29 September 2016 ................................................................................................................................................................................................................................................................................................................................ 20202020

New concepts and methodologies in particle toxicology ............................................................. 20 Particles in the environment and the link to human toxicology .................................................. 20 Future directions in particle and fibre research ........................................................................... 22 Award session .............................................................................................................................. 23

Friday 30 September 2016Friday 30 September 2016Friday 30 September 2016Friday 30 September 2016 .................................................................................................................................................................................................................................................................................................................................................... 24242424

Training: Nanomaterials in the environment and food chain ...................................................... 24 Training: Successful in-vitro testing of particle effects ................................................................ 24

Directions to the VenueDirections to the VenueDirections to the VenueDirections to the Venue .................................................................................................................................................................................................................................................................................................................................................................... 25252525

Conference room and exhibition mapConference room and exhibition mapConference room and exhibition mapConference room and exhibition map ................................................................................................................................................................................................................................................................................ 26262626

International Scientific Advisory CommitteeInternational Scientific Advisory CommitteeInternational Scientific Advisory CommitteeInternational Scientific Advisory Committee ........................................................................................................................................................................................................................................ 27272727

Conference officeConference officeConference officeConference office ........................................................................................................................................................................................................................................................................................................................................................................................................ 28282828

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Programme in a nutshellProgramme in a nutshellProgramme in a nutshellProgramme in a nutshell

Monday, 26 September 2016

08:30-09:15 Registration

09:15-11:15 Opening session: The big picture – setting the stage

11:45-13:45 Control and characterisation of exposure, routes of entry,

and translocation in the body

13:45-14:45 Lunch break

14:45-16:30 Particles for diagnosis and

therapy

Technical challenges in particle

toxicology

16:45-18:00 A*STAR session on

predictive toxicology

Tuesday, 27 September 2016

08:30-11:00 Particle sources and properties linked to toxicology

11:30-13:30 Immunity and systemic

responses

Non-specific effects of particles


14:30-16:30 Particles and the

developing body

Raising to the challenge of

complex nanomaterials in EHS

16:30-18:00 Poster session

With coffee, juice and appetizers

18:30-22:00 Dinner banquet

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Wednesday 28 September 2016

08:30-10:30 Bioavailability,

biopersistence,

bioprocessing,

biomodification, and

bioclearance

Lessons from fibrous and

mineral particles for

nanoparticle risk

management and

governance

11:00-13:00 Forest and coal fire particles


14:00-17:00 Special Symposium:

Airborne ultra-fine particles

and environmental public

health implications in

Singapore – toxicology,

exposure, mitigation

Individual networking and

sightseeing

Thursday 29 September 2016

08:30-10:30 New concepts and

methodologies in particle

toxicology

Particles in the environment

and the link to human

toxicology

11:00-12:30 Future directions in particle and fibre research


14:00-15:30 Award session

Friday 30 September 2016 – Training sessions

09:30-17:00 Nanomaterials in the

environment and food

chain

Successful in-vitro

testing of particle effects

4444

Monday, 26 September 2016Monday, 26 September 2016Monday, 26 September 2016Monday, 26 September 2016

08:30-09:15 Registration

09:15-11:15 Opening session: The big picture – setting the stage

Chair: Michael Riediker

Room: Breakthrough

Welcome by Guest of Honour

Fong Peng Keong, Director of Pollution Control Department

(DPCD), National Environment Agency, Singapore

Introduction to the conference

Michael Riediker, IOM (Institute of Occupational Medicine)

Singapore

Perspectives in particle toxicology

Flemming Cassee, RIVM, The Netherlands

Perspectives in particle medicine

Daniele Zink, IBN, A*STAR, Singapore

11:15-11:45 Coffee break

11:45-13:45 Control and characterisation of exposure, routes of

entry, and translocation in the body

Chair: Rob Aitken

Room: Breakthrough

11:45-11:55 Foreword by the session chair

11:55-12:30 Keynote: Control and characterisation of exposure, routes of

entry, and translocation in the body (including dosimetry)

Wolfgang Kreyling, Helmholtz Zentrum München, German

Research Center for Environmental Health, Germany

12:30-12:45 The challenge of creating controlled exposure aerosols of

spontaneous- or manufactured fine particles for different

exposure models from in vitro to in vivo

Per Gerde

5555

12:45-13:00 Deposition, lung clearance and translocation of four sizes of

inhaled iridium nanoparticles

Alison Buckley, Alan Hodgson, Tim Marczylo, Chang Guo, Rachel

Smith

13:00-13:15 Pulmonary location and extra-pulmonary translocation of CeO2

nanoparticles following subacute and chronic low dose

inhalation

Jutta Tentschert, Harald Jungnickel, Peter Laux, Josephine

Brunner, Philipp Reichardt, Irina Estrela-Lopis, Carolin Merkers,

Heinrich Ernst, Jana Keller, Lan Ma-Hock, Robert Landsiedel,

Thomas Gebel, Andreas Luch (presented by Lars Leibrock)

13:15-13:30 Dose – Response - relationship of nanoparticles in alveolar cells

Julia Böttner, Antje Vennemann, Martin Wiemann, Irina Estrela-

Lopis


14:30-16:30 Particles for diagnosis and

therapy

Chair: Daniele Zink

Room: Breakthrough

Technical challenges in

particle toxicology

Chair: Arti Shukla

Room: Discovery

14:30-14:40 Foreword by the session chair Foreword by the session chair

14:40-15:15 Keynote: Particles for

diagnosis and therapy

Yi Yan Yang, A*STAR,

Singapore

Keynote: Technical challenges

in particle toxicology

Phil Demokritou, Center of

Nanotechnology and

Nanotoxicology, Harvard

University, Boston, USA

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15:15-15:30 Toxicological effects of

graphene oxide-mesoporous

silica nanohybrid in human

mesenchymal stem cells

Kim Truc Nguyen, Chor Yong

Tay

Visualization and

quantification of nanoparticles

at single cell level by means of

element- and molecule based

imaging and dosimetric

techniques

Carolin Merker, Marco Dorn,

Jana Keller, Sibylle Gröters,

Robert Landsiedel, Jürgen

Vogt, Jan Meijer, Irina Estrela-

Lopis

15:30-15:45 Bacterial toxicity: A

comparison between silver,

titanium dioxide and

hydroxyapatite nanoparticles

Alexandros Besinis, Sanna

Hadi, Christopher Tredwin,

Richard Handy

Biocoronas modulate gold

nanoparticle cell uptake in

vascular endothelial cells

Nancy Monteiro-Riviere,

Parwarthy Chandran

15:45-16:00 Modulation of the pulmonary

immune response by size and

surface composition of

biomedical nanoparticles

Fabian Blank, Rebecca Blom,

Emilie Seydoux, Mario

Amacker, Christian Moser,

Laura Rodriguez-Lorenzo,

Kleanthis Fytianos, Alke Petri-

Fink, Barbara Rothen-

Rutishauser, Christophe von

Garnier

Nanoparticles and brain health

Anna Bencsik, Irina Guseva-

Canu

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16:00-16:15 Biocompatibility of surface-

modified titanium implants

with silver and hydroxyapatite

nanoparticles

Ranj Salaie, Alexandros Besinis,

Huirong Le, Christopher

Tredwin, Richard Handy

Detection and characterization

of nanoparticle corona in food

products

Ridhwan Yusoff, Paul Chiew,

Zheng Ming Wang, Kee Woei

Ng

16:15-16:30 Interaction of liposomes and

foam cells for atherosclerosis

treatment

Jinkai Tang, Luong T. H.

Nguyen, Anastasia Darwitan,

Aristo Muktabar 1, Subbu S.

Venkatraman, Kee Woei Ng

Supercritical CO2 extraction as

an efficient tool for FFF sample

pretreatment – Application

toward sunscreen

formulations and evaluation of

the extraction efficiency using

AF4-UV-MALS

Florian Meier, Lisa Schilder,

David Müller, Stefano

Cattaneo, Tjerk de Vries, Luigi

Calzolai, Thorsten Klein, Robert

Reed

16:30-16:45 Tea break

16:45-18:00 Special A*STAR session:

“Particle toxicity testing in

the 21st century”

Chair: Loo Lit Hsin

Room: Breakthrough

16:45-17:15 Genomic and phenotypic

profiling approaches for

uncovering novel mechanisms

and end points for particle

induced pulmonary toxicity

Loo Lit Hsin, Bioinformatics

Institute

8888

17:15-17:45 Development of in vitro liver

cell models with applications

to particle toxicity

Hanry Yu, Institute of

Bioengineering and

Nanotechnology

17:45-18:00 Predictive toxicology with

machine Learning

Hu Yongli, Institute for

Infocomm Research

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Tuesday, 27 September 2016Tuesday, 27 September 2016Tuesday, 27 September 2016Tuesday, 27 September 2016

08:30-11:00 Particle sources and properties linked to toxicology

Chair: Günter Oberdörster

Co-Chair: Qamar Rahman

Room: Breakthrough


08:40-09:15 Keynote: Particle sources and properties linked to toxicology

Rodger Duffin, The University of Edinburgh, Edinburgh, UK

09:15-09:30 Increase in oxidative stress levels following welding fume

inhalation: A controlled human exposure study

Halshka Graczyk, Nastassja Lewinski, Jiayuan Zhao, Jean-

Jacques Sauvain, Guillaume Suarez, Pascal Wild, Brigitta

Danuser, Michael Riediker

09:30-09:45 Selective autophagy induced by particulate matter in vitro

Hsiao-Chi Chuang, Kai-Jen Chuang, Kang-Yun Lee

09:45-10:00 TBD

10:00-10:15 Toxicological assessment of shape-engineered titanium dioxide

nanoparticles

Roel P.F. Schins, Catrin Albrecht, Julia Kolling, Alessandra Buffa,

Francesco Pellegrino, Arianna M. Marucco, Gianmario Martra,

Ivana Fenoglio

10:15-10:30 The influence of the redox activity of inhaled nano-sized cerium

dioxide on respiratory, cardiovascular and neurological effects

in various mouse models

Susan Dekkers, Paul Fokkens, John Boere, Harm Heusinkveld,

Daan Leseman, Christine Soputan, Jolanda Vermeulen, Eric

Gremmer, Liset de la Fonteyne, Isabella Römer, Marie-France

Belinga-Desaunay-Nault, Mike Russ, Tina Wahle, Adriana

Sofranko, Catrin Albrecht, Roel Schins, Shea Connell, Mark

Miller, Rob Vandebriel, Wim de Jong, Flemming Cassee

10101010

10:30-11:00 Keynote: Bioprocessing and tissue interactions of engineered

particles

Uschi Graham, Center for Applied Energy Research, University

of Kentucky, USA


11:30-13:30 Immunity and systemic

responses

Chair: Roel Schins

Room: Breakthrough

Non-specific effects of

particles

Chair: Saji George

Room: Discovery


11:40-12:15 Keynote: Immunity and

systemic responses

Albert Duschl, Department of

Molecular Biology, University

of Salzburg, Austria

Keynote: Non-specific effects

of particles

Gaku Ichihara, Faculty of

Pharmaceutical Sciences,

Tokyo University of Science,

Japan

12:15-12:30 Endotoxin nanovesicles:

Hydrophilic gold nanodots

control supramolecular

lipopolysaccharide assembly

for modulating immunological

responses

Yueh-Hsia Luo, Zong Wei Wu,

Hui-Ti Tsai, Shu-Yi Lin, Pinpin

Lin

Short-term exposure to

ultrafine particles and

cardiovascular effects among

vulnerable population in

Taipei, Taiwan

Tsun-Jen Cheng, Kang-Yun Lee,

Hsiao-Chi Chuang, Ta-Chih

Hsiao, Kai-Jen Chuang

11111111

12:30-12:45 Induction of fibrotic responses

following injection of multi-

walled carbon nanotubes in

the pleural cavity, and

modification by the IL1 genes

Yke J. Arnoldussen, Vidar

Skaug, Kristine Anmarkrud,

Fang Chin-Lin, Elin Einarsdottir,

Cesilie Granum, Mayes Kasem,

Einar Eilertsen, Ron Apte, Aage

Haugen, Shan Zienolddiny

Association of short-term and

long-term exposure of

particulate matters with

inflammatory markers in the

general population

Dai-Hua Tsai, Michael Riediker,

Antoine Berchet, Fred Paccaud,

Gerard Waeber, Peter

Vollenweider, Murielle Bochud

12:45-13:00 Targeting FGF2 signaling as a

potential key to unlocking

Asbestos-induced mesothelial

to fibroblastic transition

Joyce Thompson, Maximilian

MacPherson, Arti Shukla

The effect of size-segregated

ambient particulate matter on

allergic airway inflammation in

mice

Kuo-Liang Huang, Szu-Yuan

Liu, Charles Chou, Tsun-Jen

Cheng

13:00-13:15 No involvement of alveolar

macrophages in the initiation

of carbon nanoparticle induced

acute lung inflammation in

mice

Shanze Chen, Renfu Yin Yin,

Kathrin Mutze Mutze, Youjia

Yu Yu, Shinji Takenaka

Takenaka, Melanie Königshoff

Königshoff, Tobias Stoeger

Stoeger

Do the nano-TiO2 sunscreens

prevent oxidative stress

caused by UV radiation?

Sergey Zakharov, Zdenka

Fenclova, Tomas Navratil,

Stepanka Vlckova, Kamila

Syslova, Vit Petrik, Petr Kacer,

Daniela Pelclova

12121212

13:15-13:30 Effects of SiO2 and CeO2

nanoparticles on Alzheimer-

like pathology in mice after 3

and 14 weeks oral exposure

Catrin Albrecht, Roel P.F.

Schins, Tina Wahle, Adriana

Sofranko, Harm J. Heusinkveld,

Julia Kolling, Waluree

Thongkam, Paul M. Peeters

Peeters, Miriam Grosse-Hovest

Endothelial responses of the

alveolar barrier in vitro in a

realistic dose-controlled

exposure to diesel exhaust

particulate matter

Arno C. Gutleb, Sebastian Klein,

Sylvain Legay, Jenny Hennen,

Andreas Krein, Tommaso

Serchi, Sébastien Cambier,

Brunhilde Blömeke


14:30-16:30 Particles and the

developing body

Chair: Tsun Jen Cheng

Room: Breakthrough

Raising to the challenge of

complex nanomaterials in

EHS

Chair: Gaku Ichihara

Room: Discovery


14:40-15:15 Keynote: Nanoparticle impact

on developing fetus and

offspring

Masakazu Umezawa, Center

for Environmental Health

Science for the Next

Generation, Tokyo University

of Science, Japan

Keynote: Raising to the

challenge of complex

nanomaterials in EHS

Lanry Yung Lin Yue,

Department of Chemical and

Biomolecular Engineering,

National University of

Singapore

13131313

15:15-15:30 Effects of antioxidant

preadministration on the long-

term damage of astrocytes

induced by maternal exposure

to carbon black nanoparticle in

mice

Atsuto Onoda, Ken Takeda,

Masakazu Umezawa

Exposures to nanoTiO2 in

workers: elevated markers of

oxidative stress and

inflammation in the exhaled

breath condensate

Daniela Pelclova, Vladimir

Zdimal, Petr Kacer, Zdenka

Fenclova, Stepanka Vlckova,

Martin Komarc, Nadezda

Zikova, Jaroslav Schwarz,

Otakar Makes, Kamila Syslova,

Sergey Zakharov

15:30-15:45 Establishment of an olfactory-

based spatial learning test for

neonatal mice and the effects

of perinatal exposure to diesel

exhaust origin secondary

organic aerosol

Tin-Tin Win-Shwe, Chaw Kyi-

Tha-Thu, Yadanar Moe, Yuji

Fujitani, Shinji Tsukahara,

Seishiro Hirano

Effects of polyamidoamine

(PAMAM) dendrimers as a

model of environmental

nanoparticle on human stem

cells in neurosphere assay

Hideko Sone, Yang Zeng,

Yoshika Kurokawa, Tin-Tin

Win-Shwe, Seishiro Hirano

15:45-16:00

Exposure to PM2.5 causes

genetic changes in fetal rat

cerebral cortex and

hippocampus

Ming-Wei Chao, Meng-Chi

Chung, Yu-Jung Chang, Chia-Yi

Tseng

Effects of aerosolized multi-

walled carbon nanotubes in

chronic obstructive pulmonary

disease cells

Seraina Beyeler

14141414

16:00-16:15 Epigenotoxic investigation of

tritiated and non tritated ITER-

like tungsten particles in lung-

derived cells: the PASSIV-ITER

project

Chiara Uboldi, Elodie Bernard,

Isabelle George, Marcos

Sanles, Stephane Roche,

Frederique Magdinier, Gregory

Pieters, Bernard Rousseau,

Gheorghe Dinescu, Laurence

Lebaron-Jacobs, Philippe

Delaporte, Jerome Rose,

Veronique Malard, Christian

Grisolia, Thierry Orsiere

Implications of chemical

composition, size and redox

activity of nanoparticles on

immunological responses in

vitro

Susan Dekkers, Jolanda

Vermeulen, Elmer Harms,

Geert van der Horst, Rory

Verhagen, Jason Dirkx, Jasper

Wigger, Isabella Römer, Mike

Russ, Selina Tang, Flemming

Cassee, Wim de Jong, Rob

Vandebriel

16:15-16:30 Changes in gene expression in

human umbilical vein

endothelial cells following

exposure to PM10 are

associated with alterations in

clot formation in vitro

Xiaoxi Pan, Yun Yun Gong,

Robert AS Ariens, Michael N

Routledge

Characterization of metalic

nanoparticles in tattoo ink

using Asymmetrical Flow Field-

Flow Fractionation coupled

with ICP-MS

Lisa Schilder, Soheyl Tadjiki,

Tony Pfaffe, Evelin

Moldenhauer, Thorsten Klein,

Robert Reed

16:30-18:00 Poster session

With coffee, juice and appetizers

18:00 Departure to banquet by bus (meet at building entrance)

18:30-22:00 Dinner banquet

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WednesdayWednesdayWednesdayWednesday 28 September 201628 September 201628 September 201628 September 2016

08:30-10:30 Bioavailability,

biopersistence,

bioprocessing,


bioclearance

Chair: Chunying Chen

Room: Breakthrough

Lessons from fibrous and

mineral particles for

nanoparticle risk management

and governance

Chair: André Gazso

Room: Discovery

08:30-08:40 Foreword by the

session chair

08:30-08:45 Governing risk - Setting

the frame

Sally Tinkle

08:40-09:15 Keynote:

Bioavailability,

biopersistence,

bioprocessing,


bioclearance

Iseult Lynch, School of

Geography, Earth and

Environmental Sciences,

University of

Birmingham, UK

08:45-08:55 Management of asbestos

– Singapore’s experience

Min Hwee Lim, Evelyn

Koh, Kenneth Choy, Kia

Tang Tan, Siok Lin Gan

09:15-09:30 Predicting and

modeling in vivo

nanoparticle

biodistribution: Caveats

to making in vitro and

rodent interspecies

extrapolations

Jim Riviere, Nancy

Monteiro-Riviere

08:57-09:07 Critical look at different

approaches in the

grouping of

nanomaterials for the

purpose of hazard and

risk assessment

Mary Gulumian

16161616

09:30-09:45 Deciphering cell-

nanoparticle

interactions: Focus on

nanosafety

Angela Ivask, Meeri

Visnapuu, Pascal

Vallotton, Ezzat R.

Marzouk, Villem Aruoja,

Enzo Lombi, Nicolas H.

Voelcker

09:09-09:19 Towards a general model

to predict the toxicity of

mineral fibres? The

perspective of the fibre.

Alessandro Francesco

Gualtieri

09:45-10:00 In vitro acellular

dissolution of mineral

fibres

Alessandro Francesco

Gualtieri, Simone

Pollastri, Nicola Bursi

Gandolfi, Magdalena

Lassinanti Gualtieri

09:21-09:31 MODENA: MODElling

NAnomaterial Toxicity to

enable Safety by Design

in nanotechnologies

Bryony Ross, Andrea

Haase, Terry Wilkins,

Miguel Bañares, Tomasz

Puzyn, Lang Tran

10:00-10:15 Safe-by-design of novel

inorganic

nanomedicines for

efficient cancer

diagnosis and

photothermal therapy

in vivo

Mingjing Cao, Chunying

Chen

09:33-09:43 Carbon-based

nanomaterials in

electronic goods:

Building a risk profile for

nano-enabled batteries

at end-of-life

Bryony Ross, Araceli

Sanchez, Sheona Read,

Simon Clavaguera, Cécile

Philippot, Veronika Hase,

Martie van Tongeren

17171717

10:15-10:30 Nanodiamond uptake

and toxicity induces

alterations in

nanochemistry and

nanomechanics in 2D

and 3D liver models – a

bio-nano-spectroscopy

study

Dipesh Khanal, Alexey

Kondyurin, Iqbal

Ramzan, Dong Fu,

Wojciech Chrzanowski

09:45-09:55 Engineered

nanomaterials: toward

effective safety

management in research

laboratories

Thierry Meyer, Amela

Groso

10:00-10:30 Panel discussion

Chaired by André Gazso


11:00-13:00 Particles from forest & coal fires and other incidental

sources

Chair: Flemming Cassee

Room: Breakthrough and Discovery (merged)


11:10-11:45 Keynote: Forest and coal fire particles

Alan Vette, US EPA

11:45-12:00 Responses of normal and diseased airway epithelia to different

particle types at ambient concentration levels

Marianne Geiser, Manuel Krapf, Lisa Künzi, Sandrine Allenbach,

Jun Zhou, Imad El Haddad, Emily Bruns, Urs Baltensperger,

Josef Dommen

12:00-12:15 Chemical characteristics and biological effect of biomass (rice

straw) burning particles

Injeong Kim, Kwangyul Lee, Kihong Park, Sang Don Kim

12:15-12:30 Influence of combustion phases on particle emissions in a

residential coal-burning brazier

Masilu Daniel Masekameni, Tafadzwa Makonese, Mary

Gulumian

18181818

12:30-12:45 Airborne nanoparticle pollution in a wire electrical discharge

machining workshop and potential health risks

Jie Ding, Rui Chen, Xiaofei Shi, Ru Bai, Weiqing Rang, Lingling

Huo, Lin Zhao, Dingxin Long, David Y.H. Pui

12:45-13:00 Comparative analysis of black carbon exposure in school

children and characteristics of particulate matter collected

during haze and non-haze periods in Singapore

Saji George, Mei Ling Chua, Crystal Yu Fang Hay, Dyan Zhang

Zhewei, Reshmi Das, John E Connolly, Veonice Bijin Au, Biju

Thomas


19191919

14:00-18:00 Special Symposium:

Airborne ultra-fine particles and environmental public

health implications in Singapore – toxicology, exposure,

mitigation

Chair: Michael Riediker

Room: Breakthrough and Discovery (merged)

14:00-14:10 Singapore’s ambient and indoor air quality monitoring

framework

Ng Lee Ching, NEA, The IEQ consortium, Singapore

14:10-14:30 Interrelated concepts of exposure, dosimetry and dose-metrics

for nanomaterial risk assessment

Günter Oberdörster, Uni Rochester, NY, USA

14:30-14:50 Unintentionally released particles & health effects: risk that

requires mitigation

Flemming Cassee, RIVM, NL

14:50-15:10 Policy and research direction in term of public health and

environmental management

Alan Vette, U.S. EPA

15:10-15:30 Tea break

15:30-15:45 Collection and Characterization of Airborne Particulate Matters

from the Indoor Atmospheres of Childcare Centres

Mei Ling Chua, Wendy Melyana, Nurul Khairin Bte Abdul Rashid,

Crystal Hay Yu Fang, Gayatri Sankaran, Saji George, NYP

15:45-16:00 Particulate matter exposure during Haze

Victor Chang, NTU

16:00-16:15 Mitigation of haze particles in naturally ventilated and air-

conditioned buildings

Ganesh Parshetti, NUS

16:15-17:00 Panel Discussion with Günter Oberdörster, Flemming Cassee,

Alan Vette and Ng Lee Ching

Moderator: Michael Riediker

17:00-18:00 Networking session/reception

Evening Self-organised

20202020

Thursday 29 September 2016 Thursday 29 September 2016 Thursday 29 September 2016 Thursday 29 September 2016

08:30-10:30 New concepts and


toxicology

Chair: Lanry Yung Lin Yue

Room: Breakthrough

Particles in the

environment and the link

to human toxicology

Chair: Alan Vette

Room: Discovery


08:40-09:15 Keynote: New concepts and


toxicology

Chunying Chen, National

Center for Nanosciences and

Technology of China, Chinese

Academy of Sciences (CAS),

Beijing

Keynote: Particles in the

environment and the link to

human toxicology

Richard Handy, School of

Biological Science, Plymouth

University, UK

09:15-09:30 Asbestos and carbon

nanotube-induced

mesothelial cell pathogenesis

involves inflammasome

activation via unfolded

protein response

Arti Shukla, Maximilian

MacPherson, Joyce

Thompson, Phillip Munson,

Stacie Beuschel

Toxicity of copper

nanoparticles in zebrafish

embryos: Influence of pH and

effects of repeat pulse

exposures

Richard D. Handy, David Boyle

21212121

09:30-09:45 Nitrative DNA damage

induced by multi-walled

carbon nanotube in human

lung epithelial cells via

HMGB1-RAGE interaction and

Toll-like receptor 9 activation

Yusuke Hiraku, Feiye Guo,

Ning Ma, Tatsuhiko Yamada,

Shumin Wang, Shosuke

Kawanishi, Mariko Murata

A comparison of two Air-

liquid Interface systems

Leigh-Anne Koekemoer,

Hedwig Braakhuis, Susan

Dekkers, Harm Heusinkveld,

Paul Fokkens, John Boere,

Mary Gulumian, Flemming

Cassee

09:45-10:00 Genetically encoded

fluorescent protein and cell

sensors for nanotoxicity

studies

Fang You, Lanry Yung

Lactoperoxidase mediated

biodegradation of single-

walled carbon nanotubes:

implications for respiratory

exposure to carbon

nanotubes.

Kunal Bhattacharya, Sourav

Mukherjee Mukherjee, Ramy

El-Sayed, Hu Li, Klaus Leifer,

Andrea Fornara, Birgit

Brandner, Yichen Zhao,

Muhammet Toprak, Wanji

Seo, Alexander Star, Bengt

Fadeel

10:00-10:15 A spectroscopic approach for

toxicity assessment of

nanomaterials

Mustafa Culha, Gamze Kuku,

Melike Saricam

The effects of nanoparticle

surface charge on corona

formation in biological media

Luong T. H. Nguyen, Shu Fen

Chua, Kee Woei Ng

22222222

10:15-10:30 Shape dependent pulmonary

toxicity induced by graphene

based nanomaterials in Swiss

albino mice

Sandeep Mittal, Alok K

Pandey

Comparison on size

distribution and

concentration of

nanoparticles between

photocatalytic and regular

cement in an aerosolization

system

Kiattisak Batsungnoen, Nancy

Brenna Hopf, Guillaume

Suarez, Michael Riediker


11:00-12:30 Future directions in particle and fibre research

Chair: Ng Kee Woei

Room: Breakthrough


11:10-11:45 Keynote: Future directions in nanomaterial research

Srikanth Nadadur, National Institute of Environmental Health

Sciences, USA

11:45-12:30 Open discussion about future research directions

Chair: Ng Kee Woei


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14:00-15:30 Award session

Chair: Rob Aitken

Room: Breakthrough

14:00-14:30 Lifetime achievement award

(laudation by Wolfgang Kreyling & 25 min talk by awardee)

14:30-14:45 Young Investigator Award in Memory of Dr. Val Vallyathan

(laudation by Arti Shukla & 5 min. talk by awardee)

14:45-15:00 ANF-Asia Nano Safe Prize

(laudation by Gaku Ichihara & 5 min. talk by awardee)

15:00-15:15 Best paper of the year award (of papers published in Particle

and Fibre Toxicology)

(laudation by Roel Schins & 5 min. talk by awardee)

15:15-15:30 Closing words

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Friday 30 September 2016Friday 30 September 2016Friday 30 September 2016Friday 30 September 2016

09:30-17:00 Training: Nanomaterials

in the environment and

food chain

Training: Successful in-

vitro testing of particle

effects

09:00-09:30 Registration for training



chain

Successful in-vitro testing of

particle effects




chain (continued)


particle effects

(continued)




chain (continued)


particle effects

(continued)

25252525

Directions to the Directions to the Directions to the Directions to the VenueVenueVenueVenue The conference will be held at the Biopolis neighbourhood in the 4th Floor

Conference rooms of Biopolis Matrix, 30 Biopolis Street, Singapore, 138671.

Map of Biopolis showing in

highlight Buona Vista MRT,

Biopolis Matrix and

Rochester Park Avenue Hotel.

Metro map of Singapore with Buona Vista MRT station highlighted.

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Conference room and exhibition mapConference room and exhibition mapConference room and exhibition mapConference room and exhibition map

Training rooms

The training events of Friday 30 September will be at the same venue but on the

3rd floor, in the meeting rooms below the poster section.

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International International International International Scientific Scientific Scientific Scientific Advisory Advisory Advisory Advisory CommitteeCommitteeCommitteeCommittee

Michael Riediker Institute of Occupational Medicine, Singapore

Daniele Zink Institute of Bioengineering and Nanotechnology,

Singapore

Kee Woei Ng Nanyang Technological University, Singapore

Vicki Stone Heriot-Watt University, Edinburgh, Scotland

Lang Tran Institute of Occupational Medicine, Edinburgh, Scotland

Roel Schins Leibniz Research Institute for Environmental Medicine,

Dusseldorf, Germany

Flemming Cassee National Institute for Public Health and the

Environment, Bilthoven, The Netherlands

Rob Aitken Institute of Occupational Medicine, and Heriot-Watt

University, Edinburgh, Scotland

Gunter Oberdörster University of Rochester Medical Centre, New York, USA

Brooke Mossman University of Vermont, Vermont, USA

Paul Borm Centre of Expertise in Life Sciences, Heerlen, The

Netherlands

Chunying Chen National Center for Nanoscience and Technology,

Bejing, China

Saji George Centre for Sustainable Nanotechnology, Nanyang

Polytechnic, Singapore

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Conference Conference Conference Conference officeofficeofficeoffice

IPTC2016 – 11th International Particle Toxicology Conference

IOM (Institute of Occupational Medicine) Singapore

30 Raffles Place, @17-00 Chevron House

048622 Singapore

[email protected]

http://iptc2016.sg

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NotesNotesNotesNotes

Thank you!

We acknowledge the generous support provided by:

Gold-sponsor

Silver-sponsors

Bronze-sponsors

Other sponsors

Biomed Central – The Open

Access Publisher

Gaku Ichihara (donation)

Sahoko Ichihara (donation)

Documents

IPTC2016 Programme (2016-09-22)...entry, and translocation in the body (including dosimetry) Wolfgang Kreyling, Helmholtz Zentrum München, German Research Center for Environmental