View
216
Download
0
Tags:
Embed Size (px)
Citation preview
Investigations in Deep Brain Stimulation:
Neurostimulating Electrodes
March 9, 2001March 9, 2001
Tom Chiesl, Eric Faulring, Tom Chiesl, Eric Faulring,
Elizabeth Nunamaker, Jonathan YuenElizabeth Nunamaker, Jonathan Yuen
Parkinson’s Disease
• Progressive central nervous system disorder
• Degeneration of pigmented neurons of the Substantia Nigra
• Men and women over fifty
• Inability to control muscular activity
• Gait difficulty
• Rigidity
• Tremor
Traditional Treatment Options
• Drugs (Levodopa)
• Initial reduction of symptoms
• Tolerance develops over time
•Pallidotomy
•Thalamotomy
Emerging Treatment Options
• Deep Brain Stimulation (DBS)
• Placement of electrode within thalamus
• Periodic stimulation overrides faulty signals
• Intensity / Frequency adjusted as needed
Medtronics Production Electrode
Voltage (V) 3.07 1.2 3.30 1.1 3.38 1.1
Frequency (Hz) 158.1 29.1160.6 29.0 165.6 23.5
Pulse Width (sec) 107.0 47.6 105.041.5 117.5 80.8
3 Months 6 Months 12 Months
Biological Requirements of Bio-Electrodes
• Size
• Non-toxic
• Non-inflammatory / non-immunogenic
• Bio-fouling
Engineering Requirements of Bio-Electrodes
• Corrosion Resistance
• Packaging (Control, Power, Communication)
• Manufacturing Complexity / Cost
• Component Materials Compatibility
• Functionality (Maintenance, Adjustments)
• Recording Electrode - Large Capacitance
• Stimulating Electrode - Small Resistance
• High Surface Area (Minimize Electrical Impedance)
• Gas Evolution (Safe Charge Density Injection Limit)
Electrical Requirements Bio-Electrodes
Emerging Fabrication Technologies –
• Doping electrode tracings onto silicon substrate
• Evaporative metal deposition on micro-injection molded plastic substrate
• Polycrystalline silicon tracings
Current Fabrication Technologies –
• Macroscale production (Au, Pt electrodes)
• CMOS processing
• Photolithography
Emerging Fabrication Technologies -Evaporative metal deposition on micro-injection molded plastic substrate
Emerging Fabrication Technologies -• Doping electrode tracings onto silicon substrate
Quadripolar Electrode
Etched holes for neural growth factor and nerve in-growth
Summary
Use thin film CMOS technology incorporating polycrystaline electrodes or doped silicon electrodes
• Electrodes are microscale
• More electrodes for increased stimulation options
• Closed loop – feedback control
• Less destructive to neural tissue
Questions