Introduction to

Antiseptic, Disinfectants

& Insecticides

Hend Al-HussienyHend Al-HussienyBSc. Pharm, MSc.BSc. Pharm, MSc.

Head of the Biocides Vigilance DepartmentHead of the Biocides Vigilance Department

Egyptian Drug Authority (EDA) Egyptian Drug Authority (EDA) Egyptian Pharmaceutical Vigilance Center (EPVEgyptian Pharmaceutical Vigilance Center (EPVC)

Biocides Vigilance Department (BVD)Biocides Vigilance Department (BVD)

Biocidal Product

Active substance and preparations containing one or

more active substances, in the form which are

supplied to the user, intended to destroy, deter,

render harmless, prevent the action of, or

otherwise exert a controlling effect on any

harmful organism by chemical or biological

means.

Uses of Biocides

International Classification of Biocidal Product

According to International Classification the

Biocidal Product is Sub-Divided into:

   1- Antiseptic & Disinfectant.

   2- Insecticide.

Classification Diagram

Antiseptic tic

 

An antiseptic product is considered to be one

that inactivates, reduces, prevents or arrests

growth of microorganisms with the inherent

intent to mitigate or prevent disease. as

bacteria, yeast, fungi, and viruses.

Antiseptic Classification

1. Personal use antiseptics:

1.1 Personal domestic use antiseptics.

1.2. Personal commercial use antiseptics.

2. Professional use antiseptics:

2.1. Food premises antiseptics.

2.2. Professional healthcare use antiseptics.

 

Personal use antiseptics

1. Personal domestic use antiseptics

Personal domestic (or household) use

antiseptic products are those used by an

individual in a domestic setting to reduce

transient organisms on the skin.

Personal use antiseptics

This includes, but may not be limited to,

consumer-use first aid antiseptics for

application in cleansing minor wounds, self-

administered pre-injection or ear piercing.

Personal use antiseptics

2. Personal commercial use antiseptics

Personal commercial uses products are those

made available to the general public for

occasional use and are intended to reduce

transient organisms on the skin in a

commercial or institutional setting.

2. Professional use antiseptics

1. Food premises use antiseptics

Products for professional food premises are those

which are indicated for use by food handlers to

reduce transient organisms on the skin in a

commercial or institutional setting including

food processing plants, restaurants,

supermarkets, and fast food outlets.

Professional use antiseptics

2. Professional healthcare use antiseptics

Products for professional healthcare use are those which are indicated

for use by individuals to reduce transient and/or resident organisms

on the skin in a healthcare setting (such as hospitals, nursing homes,

clinics and dental offices). Such products are to be used in accordance

with applicable hospital protocols. These products include

professional hygienic hand rub, professional hygienic hand washes,

surgical hand rubs, surgical hand washes and patient preoperative

skin preparations.

2. Disinfectants

• The term "disinfectant" is considered to include

bactericides, fungicides, virucides, mycobactericides,

tuberculocides, sporicides, sterilants, or

combinations of these. A disinfectant without

specific target organisms indicated on the product

label is regarded only as a bactericide.

It applies to all disinfectants and disinfectant

sanitizers within the pharmaceutical frame. This

doesn’t include non-food contact sanitizers which do

not carry disinfectant claims, e.g., sanitizers with a

mission to control plant pathogens such as those used

in greenhouses, odour control sanitizers, and

swimming pool sanitizers

Classification of Disinfectants

Disinfectants

Critical use disinfectants

Present a high risk of infection if they are not

sterile, i.e. contaminated with any organism,

including spores. Routinely penetrate the skin or

mucus membranes into normally sterile areas of

the body (e.g., implants, scalpels, needles, surgical

instruments, laparoscopes), or come into direct

contact with recalculating body fluids, (e.g.,

kidney dialysis tubing and dialyzers, or blood

oxygenators).

N.B.

2. Semi-critical use disinfectants

Contact with mucous membranes during use

but do not usually penetrate normally sterile

areas of the body, e.g. endoscopes,

anesthesia breathing circuits, respiratory

therapy equipment, dental mirrors, etc…

High-level Disinfectant

A disinfectant that kills all microbial

pathogens, except Large numbers of

bacterial endospores according to

labeling.

3. Non-critical

are those products used for disinfection of

devices or surfaces that contact only intact

skin during routine use, e.g. stethoscopes,

bedpans, areas where animals are housed

…..etc.

Intermediate level disinfectant

A disinfectant that kills all microbial

pathogens, except bacterial endospores,

when used according to labeling

Sanitizer

A product that reduces the level of

microorganisms present by significant

numbers, e.g. 99.9% or more, or to

acceptable levels.

Low-level Disinfectant

A disinfectant that kills pathogenic and

potentially pathogenic microorganisms on

hard non-porous inanimate surfaces or

inanimate objects, when used according to

labeling.

Veterinary Biocide

Veterinary hygiene biocide products are used

for veterinary hygiene purposes including

products used in areas in which animals are

housed, kept or transported.

Disinfectants VS. Sanitizers

• A Disinfectant is a product which completely destroys all

specific test organisms in 10 minutes under conditions of the

American Association of Official Analytical Chemists AOAC Use

Dilution Test.

A Sanitizer is a product which destroys 99.999% of

specified test bacteria in 30 seconds under conditions of the

Official Detergent Sanitizer Test (sometimes called Weber &

Black Test).

Pesticides

A pesticide is a chemical used to prevent, destroy, or repel

pests. Pests can be insects, mice and other animals, weeds,

fungi, or microorganisms such as bacteria and viruses. Some

examples of pests are termites causing damage to our homes,

dandelions in the lawn, and fleas on our dogs and cats.

Pesticides also are used to kill organisms that can cause

diseases.

Pesticides incidents

A pesticide incident is a negative effect to humans, animals

or the environment that can result from being exposed to a

pesticide.

Common types of pesticide incidents include:

• Effects to humans (e.g. skin rash or headache),

• Effects to a pet or a farm animal (e.g. vomiting),

• Effects to the environment (e.g. dead fish or birds), or even

• Problems with pesticide containers

WHO Classification

WHO Classification

1. House Hold

Pesticide that is used in or around the house and is

generally available over the counter. They may

include mosquito coils, aerosols spray cans,

insect repellents for personal use, rodent

poisons, cockroach sprays and baits, flea and

tick control products and pet collars.

WHO Classification

2. Public health

Pesticide that is used in the control of pests of public health

significance. They include vector control pesticides,

household pesticides, and professional pest management

pesticides (i.e. pesticides used by pest control operators). For

the purpose of this guideline, public health pesticides do not

include disinfectants

Illegal pesticide

A pesticide that is not registered or

otherwise authorized for a particular

distribution and use, or a pesticide for

which no import authorization has been

given (if applicable).

Substandard pesticide

Substandard pesticide

A pesticide product that does not

comply with National (or International,

where relevant) quality standards.

Most pesticides contain chemicals that can

be harmful to people, animals, or the

environment. For this reason the Biocides

Vigilance Department Programs regulates

pesticides in our country to protect public

health and the environment.

Examples of Pesticide Products

Some examples of pesticide products we use in our

homes

• Cockroach sprays and baits

• Mosquito sprays

• Rat poisons

• Flea and tick sprays, powders, and pet collars.

Types of Incident

There are four types of Pesticides Incidents:

1. Human Health Incident

2. Domestic Animal Incident

3. Environmental Incident

4. Packaging Incident

Applied Tests on Biocidal Product

Common tests applied on biocidal product

before granting registration license

• Safety (NODCAR)

• Efficacy ( NMRI)

• Stability (Stability Study )

Thank You