Introduction: On Banff Introduction: On Banff 2003, Aberdeen, Scotland, 2003, Aberdeen, Scotland,

and What Robert Burns and What Robert Burns Would Think!Would Think!

Kim Solez, M.D.Kim Solez, M.D.

Going to Scotland: Going to Scotland: A Good Idea!A Good Idea!

The most registrants we have The most registrants we have ever had with many new faces! ever had with many new faces! We hope that you all will join We hope that you all will join us in the summer of 2005 in us in the summer of 2005 in Edmonton for the 8th Banff Edmonton for the 8th Banff Conference on Allograft Conference on Allograft Pathology!Pathology!

Why Banff? Why Banff? Searching for the Muse(s)!Searching for the Muse(s)!

For productive discourse, For productive discourse, creativity. Doug Wilson will creativity. Doug Wilson will discuss the muses and reflect discuss the muses and reflect back on the meeting’s history back on the meeting’s history from 1991 on, on Tuesday the from 1991 on, on Tuesday the 17th.17th.

Aberdeen - Close to but Aberdeen - Close to but not Banff! not Banff!

Future Banff Meetings:Future Banff Meetings:2005: Edmonton, Canada2005: Edmonton, Canada 2007: Edinburgh, 2007: Edinburgh, ScotlandScotland2009: Banff, Canada2009: Banff, Canada

Slide Slide 66

Banff Conferences on Banff Conferences on Allograft Pathology Allograft Pathology

Global consensus Global consensus generation while generation while maintaining intellectual maintaining intellectual freedom.freedom.

Like the mosh pit at a Like the mosh pit at a great rock concert. No great rock concert. No partner, the ultimate in partner, the ultimate in individuality, dangerous, individuality, dangerous, but when the but when the music is good music is good everyone dances in everyone dances in sync and life is sync and life is good. good.

"Possess the right "Possess the right thinking, in this you must thinking, in this you must never lapse."never lapse."

Splinter - ninja master/talking Splinter - ninja master/talking rat - Teenage Mutant Ninja Turtle rat - Teenage Mutant Ninja Turtle movie (1990)movie (1990)

Dr. Racusen is largely Dr. Racusen is largely responsible for having responsible for having constructed the exciting constructed the exciting program!program!

Slide Slide 1111

Subjects in Aberdeen Banff Subjects in Aberdeen Banff meetingmeeting Updates of Schemas for Diagnosis and Updates of Schemas for Diagnosis and

Treatment of Allograft RejectionTreatment of Allograft Rejection

Chronic transplant nephropathyChronic transplant nephropathy

Genomics of RejectionGenomics of Rejection

Antibody-mediated rejection/C4d Antibody-mediated rejection/C4d

Monocyte/MacrophagesMonocyte/Macrophages

Tolerance/Accomodation/ImmunodepletionTolerance/Accomodation/Immunodepletion

Continued Development/Consensus Continued Development/Consensus Generation via Internet CommunicationGeneration via Internet Communication

Many Unique Elements in Many Unique Elements in Banff 2003: EQA slides Banff 2003: EQA slides (UK) (UK) First time as official First time as official satellite.satellite.First time ITN First time ITN represented.represented.First inclusion of historyFirst inclusion of history … and golf! … and golf!Dr. David HamiltonDr. David HamiltonFirst Video Legacy First Video Legacy interview. interview. Dr. Stewart CameronDr. Stewart Cameron

Slide Slide 1313

Banff Classification Banff Classification MilestonesMilestones 1991 First Conference, Heart Represented1991 First Conference, Heart Represented

1993 First Kidney International paper, Liver start.1993 First Kidney International paper, Liver start.

1995 Integration with CADI - identical scoring. Liver 1995 Integration with CADI - identical scoring. Liver classification.classification.

1997 Integration with CCTT classification. Liver 1997 Integration with CCTT classification. Liver classification published.classification published.

1999 Second KI paper. Clinical practice guidelines. 1999 Second KI paper. Clinical practice guidelines. Implantation biopsies, microwave. Liver chr. Implantation biopsies, microwave. Liver chr. reject.reject.

2001 Classification of antibody-mediated rejection. 2001 Classification of antibody-mediated rejection. Regulatory agencies participating. Heart progress.Regulatory agencies participating. Heart progress.

Slide Slide 1414

Banff Classification ImpactBanff Classification Impact

291 publications containing the 291 publications containing the word “Banff”!word “Banff”!

100 publications containing the 100 publications containing the phrase “Banff Classification”!phrase “Banff Classification”!

Slide Slide 1515

Banff Classification Key Banff Classification Key PublicationsPublications 1993 Solez et al. International standardization 1993 Solez et al. International standardization

of criteria for the histologic diagnosis of renal of criteria for the histologic diagnosis of renal allograft rejection: the Banff working allograft rejection: the Banff working classification of kidney transplant pathology. classification of kidney transplant pathology. Kidney Int. 1993 Aug;44(2):411-22.Kidney Int. 1993 Aug;44(2):411-22.

1997 Banff schema for grading liver allograft 1997 Banff schema for grading liver allograft rejection: an international consensus rejection: an international consensus document.Hepatology. 1997 Mar;25(3):658-63document.Hepatology. 1997 Mar;25(3):658-63

1999 Racusen et al. The Banff 97 working 1999 Racusen et al. The Banff 97 working classification of renal allograft pathology. classification of renal allograft pathology. Kidney Int. 1999 Feb;55(2):713-23. Kidney Int. 1999 Feb;55(2):713-23.

Slide Slide 1616

Banff Classification Key Banff Classification Key Publications (cont.)Publications (cont.)

2001 Demetris et al, Update of the 2001 Demetris et al, Update of the International Banff Schema for Liver International Banff Schema for Liver Allograft Rejection: working Allograft Rejection: working recommendations for the histopathologic recommendations for the histopathologic staging and reporting of chronic rejection. staging and reporting of chronic rejection. An International Panel. Hepatology. 2000 An International Panel. Hepatology. 2000 Mar;31(3):792-9.Mar;31(3):792-9.

2003 Rodriguez ER; International Society 2003 Rodriguez ER; International Society for Heart and Lung Transplantation. The for Heart and Lung Transplantation. The pathology of heart transplant biopsy pathology of heart transplant biopsy specimens: revisiting the 1990 ISHLT specimens: revisiting the 1990 ISHLT working formulation. J Heart Lung working formulation. J Heart Lung Transplant. 2003 Jan;22(1):3-15.Transplant. 2003 Jan;22(1):3-15.

Slide Slide 1717

Banff Classification Key Publications Banff Classification Key Publications (cont.)(cont.)

2003 Racusen, Colvin, Solez et al. 2003 Racusen, Colvin, Solez et al. Antibody-Mediated Rejection Criteria - Antibody-Mediated Rejection Criteria - an Addition to the Banff '97 an Addition to the Banff '97 Classification of Renal Allograft Classification of Renal Allograft Rejection.Am J Transplant. 2003 Rejection.Am J Transplant. 2003 Jun;3(6):708-714.Jun;3(6):708-714.

What would Robert Burns What would Robert Burns have thought of us? He was have thought of us? He was a strong supporter of a strong supporter of internationalism and love in internationalism and love in all its senses, including that all its senses, including that in moshing and Town Halls!in moshing and Town Halls!So probably he would have So probably he would have approved!approved!

““A Man’s A Man for a’ A Man’s A Man for a’ That” by Robert BurnsThat” by Robert BurnsThen let us pray that come what may, Then let us pray that come what may, (As come it will for a’ that) (As come it will for a’ that) That Sense and Worth, o’er a’ the earth, That Sense and Worth, o’er a’ the earth, May bear the gree* and a’ that, May bear the gree* and a’ that, For a’ that, a’ a’ that,For a’ that, a’ a’ that,It’s coming yet for a’ that. It’s coming yet for a’ that. That Man to Man, the world o’er,That Man to Man, the world o’er,Shall brothers be for a’ that!Shall brothers be for a’ that!

*gree = be victorious*gree = be victorious

Hope this presentation has been Hope this presentation has been useful to you even if you do not useful to you even if you do not completely agree!completely agree!Commander Lock: Not everyone believes Commander Lock: Not everyone believes what you do, Morpheus. what you do, Morpheus. Morpheus: My beliefs do not require them Morpheus: My beliefs do not require them to. to.

from Thefrom The Matrix Reloaded Matrix Reloaded (Released May 15,2003)(Released May 15,2003)

Drs. Solez and Racusen would Drs. Solez and Racusen would like to thank … our sponsors:like to thank … our sponsors:

Fujisawa GmbHFujisawa GmbHNovartis PharmaceuticalsNovartis PharmaceuticalsPfizer Inc. Pfizer Inc. SangStat Medical Corporation SangStat Medical Corporation Wyeth-Ayerst PharmaceuticalsWyeth-Ayerst PharmaceuticalsOlympus MicroscopesOlympus Microscopes

The National Kidney Foundation, USThe National Kidney Foundation, US

Standards/Guidelines leaders:Standards/Guidelines leaders:

The National Kidney Foundation, USThe National Kidney Foundation, US

DOQI guidelines (bone latest)DOQI guidelines (bone latest)

NKF cyberNephrologyNKF cyberNephrology

Banff ConferencesBanff Conferences

Drs. Solez and Racusen would Drs. Solez and Racusen would like to thank … our co-like to thank … our co-organizers:organizers:

Dr. Dr. Jake DemetrisJake DemetrisDr. Rene RodriguezDr. Rene Rodriguez

Drs. Solez and Racusen would Drs. Solez and Racusen would like to thank … our hosts:like to thank … our hosts:

The University of AberdeenThe University of AberdeenThe City of AberdeenThe City of Aberdeen

Drs. Solez and Racusen would Drs. Solez and Racusen would like to thank … our local like to thank … our local organizers:organizers:

Prof. John SimpsonProf. John Simpsonand staffand staff Prof. Andy ReesProf. Andy Reesand staffand staff

Drs. Solez and Racusen would Drs. Solez and Racusen would like to thank … our tour guide:like to thank … our tour guide:

Elma McMenemyElma McMenemy

Drs. Solez and Racusen would Drs. Solez and Racusen would like to thank … our meeting like to thank … our meeting coordinator:coordinator:

Michele HalesMichele Hales

Please visit the posters!Please visit the posters!

Monday, 16 June 2003 Monday, 16 June 2003 8:00 - 8:308:00 - 8:30 Poster Viewing - Near Poster Viewing - Near Linklater RoomLinklater Room1:30 - 12:301:30 - 12:30 Poster Viewing - Near Poster Viewing - Near Linklater RoomLinklater Room        Afternoon free for delegates, except Afternoon free for delegates, except for those attending the Liver Sessionsfor those attending the Liver Sessions

Final housekeeping remarks.Final housekeeping remarks.

Be on time for buses!Be on time for buses!Book tours today! Book tours today! Leave us your PowerPoint file!Leave us your PowerPoint file!We wish you an enjoyable and We wish you an enjoyable and profitable conference!profitable conference!Come back in 2005, 2007, 2009 etc.!Come back in 2005, 2007, 2009 etc.!