Introduction

December 3rd, 2003

Presenting:

DSBR

Literature

Recommendations

VenusVal HammackVenusVal Hammack

Servicemen Workplace

In the heat of battle/ conflict or training maneuvers, the serviceman occasionally does not have the time or supplies to protect themselves in a Chemical agent environment. This is where inadvertent adverse health exposures occur.

During the 90-91 KTO troops where told to ignore the sounding NBC alarms.

Acta Medica (Hradec Kralove 9 articles from 1999

to 2003 treatment in rats

Address Long term influence of low level sarin

Japanese Research

Chromato Analysis

J Chromatogr B Biomed Sci Appl

J Chromatogr Sci J Mol Spectrosc J Chromatogr A Rapid detection & ID

of chem agents immunoassay and enzyme inhibition

Chemical Analysis Chem Biol Interact Anal Chem J Am Chem Soc Analyst J Biol Chem. Catalyzed hydrolysis

of nerve agent by metal compunds and dection of byproducts

Recommended for Committee Review

Military Medicine

Mil Med (3ea) J R Army Med Corps Mar 2003 study long

term health effects sarin & other anticholinesterase

Dec 2001 psycho-physiological effect of sarin

Demonstrates Spin by DoD to minimalize health effects

Publications

JAMA Sci Am Lancet BMJ Nature

Better Kill through chemistry

Address quality of life issues

Occupational

Int J Occup Environ Health

Environ Health Perspect

J Hazard Mater Environ Sci Technol

Close Review by Committee Recommended

Applied Toxicology

Toxicol Appl Pharmacol

Regul Toxicol Pharmacol

Toxicol Ind Health Toxicol Lett Toxicol Sci Chem Res Toxicol Toxicology

Recommended for Committee Review

Forensic

J Health Polit Policy Law

Int J Legal Med Leg Med (Tokyo). Forensic Sci Int Harefuah -Hebrew J Assoc Acad Minor

Phys

Recommended for Committee Review

Genetics

Structure (Camb Nat Struct Biol Nat Med Nat Genet Clin Chim Acta -

Laboratory Medicine

Recommended for Committee Review

Toxicology

Drug Chem Toxicol Food Chem Toxicol Fundam Appl

Toxicol Hum Exp Toxicol. Bull Environ Contam

Toxicol Arch Toxicol. J Anal Toxicol

Recommended for Committee Review

Neurotoxicology

J Clin Neurosci Neurochem Res Neurosci Biobehav

Rev Neuroscience Synapse Need much closer

attention

Pharmacogenetics J Pharmacol Exp

Ther Indian J Physiol

Pharmacol Med Lett Drugs Ther Trends Pharmacol

Sci J Pharm Pharmacol

Address prophilica interactions

Environmental

Int J Occup Environ Health

Environ Health Perspect

Environ Sci Technol J Hazard Mater J Environ Health Address adverse

exposures

Biotech

Biotechnol Adv Biochemistry Biomed Environ Sci Biotechnol Adv. Biotechnol Bioeng Bioorg Med Chem Address sarin in

human physiology

Summary

Veterans demand that this Committee obtain and review the data from

The U.S. Army Center for Health Promotion and Preventive Medicine (USACHPPM) specifically

Cholinesterase Reference Laboratory manages the external quality assurance and quality control program for RBC-ChE activity determinations in support of the nerve agent medical surveillance program.  

Summary

Red-blood cell-cholinesterase monitoring.

Monitoring RBC-ChE by DOD contractors. Contractor may send the blood specimens to the USACHPPM Cholinesterase Reference Laboratory for primary Analysis. See study

Evaluation of Airborne Exposure Limits for G-Agents: Occupational and General Population Exposure Criteria; ERDEC TR-489, Mioduszewski et al., April 1998 and an ERRATA , SAB, Johnson, 2000.

Also other studies citations in handout.