Introducing PlexusThe ChemAxon Collaborative Research Platform

Miklos J. Szabo

Plexus Suite

Analysis

DesignEnumeration

Analysis

Filtering

Synthesis

Biology

Plexus Suite

Industry Problems Based on Interviews

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Current applications are too complex and non-intuitive

Inability/Difficulty in accessing data from multiple disparate sources

Collaboration

Loss of project-relevant information

Data sharing is difficultReporting is often problematic

ELNs are problematic – difficult to search & maintain

Access to 3D tools overwhelming & underutilized

SAR tools are too complex and non-intuitive

”Cheminformatics Solved”

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5

Plexus Suite Modules – Key Features

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Continuously Release New Capabilities

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ProjectMngt

Document To DB

Bio Assay Synth.Chem.

PS Analysis

PS Design

PS Connect

Q3 – Q4 2014

ADMET

Q1-Q22015

Q3-Q42015

Compound Reg.

Q4 2014

• Form To Spreadsheet

• R-group Analysis

• Report to Office

• Clustering

Q1-2 2015

• Relational data views

• Assay Vis & SAR

• Tell Me Everything

Q3-4 2015

• Pivot views

• Statistical Calculations

• Spectral data

• BioSAR , Biologics Enumeration

Roadmap (Sep 2014) – User Collaboration

Plexus Suite

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Simple and Intuitive UI

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Context sensitive menus

Business and Feature Toggles

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Collaboration

Role based access to forms

Role-based login

Row-level security (Oracle)

Share Query

Multifunctional Lists

CXN provides Infrastructure

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Collaboration

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Easy Access To Data

Reporting – Office Integration

Pivoted Table

JC4XL Pivoted Table

JC4O - PPT ReportLive URL

Export

Report

Report

Plexus Registration/Analysis for Biologics

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Biologics in spreadsheets

Filter by sequence or structure

Register Abs, ADCs, peptides, oligos from Plexus UI

Design workflow support

Powered by Biomolecule toolkit

Alanine scanSingle site enumeration

Plexus Design for Biologics

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MTGCRLCYWEC

ATGCRLCYWEC

MAGCRLCYWEC

MTACRLCYWEC

MTGARLCYWEC

MTGCALCYWEC

MTGCRACYWEC

MTGCRLAYWEC

MTGCRLCAWEC

MTGCRLCYAEC

MTGCRLCYWAC

MTGCRLCYWEA

MT A CRLCYWEC

MT L CRLCYWEC

MT I CRLCYWEC

MT V CRLCYWEC

MT T CRLCYWEC

MT[Dha]CRLCYWEC

MT[Hse]CRLCYWEC

MT[Nle]CRLCYWEC

MT[Nva]CRLCYWEC

MT[Sar]CRLCYWEC

MT[Aha]CRLCYWEC

Filter

RegisterMakeMeasure

What is next?

Getting Started

Technical Presentations

Recap

Demo

ps-demo.chemaxon.com

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