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Intracranial Epidural Abscess in the Setting of Sinusitis. Peter Morgenstern, MS4. M.B. 32 RHM c/o headache + retro-orbital pain x 3d Denies fevers, chills, nausea, vomiting, photophobia, neck stiffness, vision changes, nasal drainage PMH – Samter’s Triad Asthma - PowerPoint PPT Presentation
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M.B.
32 RHM c/o headache + retro-orbital pain x 3d
Denies fevers, chills, nausea, vomiting, photophobia, neck stiffness, vision changes, nasal drainage
PMH – Samter’s Triad Asthma
PSxH – Multiple nasal polypectomies (2005, 2007, 2009)
M.B.
Denies smoking, minimal alcohol use
Meds: Ventolin inhaler, fluticasone, flovent
Allergies: Aspirin, Ibuprofen
Exam Afebrile Well-appearing, uncomfortable 2/2 HA HEENT: frontal and maxillary sinus tenderness Neuro: intact
Intracranial Epidural Abscess
Predisposing factors Sinusitis Neurosurgical Procedure Trauma
Numerous causative organisms
Incidence decreasing
Morbidity/Mortality decreasing
Hlavin et al. 1994
Presentation and Diagnosis
Fever, headache, nausea/Vomiting
Confusion, agitation, seizures, hemiparesis, cranial neuropathies
Periorbital cellulitis or frontal edema (45%)1
CT and MRI
Other studies
Pradilla et al. 2009
Surgical Drainage – ENT and Neurosurgical
Trans-ethmoidal drainage1
Removal of infected bone, possible CSF diversion ENT in the acute setting2
Medical Antibiotics Possible AEDs, corticosteroids, hyperosmolar fluids Hyperbaric oxygen therapy3
Role for conservative approach4
Management
1. Patron et al. 20102. Delgaudio et al. 20103. Heran et al. 20034. Baechli et al. 2008
Outcomes
Historically poor
Favorable in most cases today
Positive predictors young age, - encephalopathy, neuro deficit, comorbidities
Negative predictors – herniation, delayed neuroimaging, delayed diagnosis
M.B.
Urgent bifrontal craniotomy
Broad-spectrum antibiotics after OR culture
Vancomycin, Gentamycin, Metronidazole
Consult with ENT and ID
Modify antibiotic coverage based on culture
M.B.
Uncomplicated post-op course
Notable improvement in symptoms
Discharged on POD #7
4-6 week course of IV vancomycin and ceftriaxone pending cultures
Culture: pan-sensitive coagulase negative staphylococcus
Conclusions
Maintain high clinical suspicion
Image early
Collaborative approach
Aggressive drainage + antibiotic therapy
Are more rigorous studies needed?
References Baechli H, Schmutz J and Mayr JM. Hyperbaric Oxygen Therapy for the treatment of an epidural abscess in the posterior fossa of an 8-month-old infant.
Pediatr Neurosurg 2008; 44: 239-242.
Enoch DA, Gillham MI, Macfarlane R, Antoun N, Sule O. A troublesome head-butt. Lancet Infect Dis 2007; 7: 694.
Erman T, Demirhindi H, Göçer AI, Tuna M, Ildan F and Boyar B. Risk factors for surgical site infections in neurosurgery patients with antibiotic prophylaxis. Surg Neurol 2005; 63(2): 107-12.
Hastings H. A Report of Two Cases of Epidural Abscess of Otitic Origin. California State Journal of Medicine 1907; 5(10): 257-260.
Heran NS, Steinbok P, Cochrane DD. Conservative neurosurgical management of intracranial epidural abscesses in children. Neurosurgery 2003; 53(4): 893-7.
Hlavin ML, Kaminski HJ, Fenstermaker RA and White RJ. Intracranial suppuration: a modern decade of postoperative subdural empyema and epidural abscess. Neurosurgery 1994; 34: 974-981.
Johnson DL, Markle BM, Wiedermann BL, Hanahan L. Treatment of intracranial abscesses associated with sinusitis in children and adolescents. J Pediatr 1988; 113: 15-23.
Kim JE, Kountakis SE. "The prevalence of Samter's triad in patients undergoing functional endoscopic sinus surgery". Ear, Nose, Throat J 2007; 86(7): 396–9.
Kombogiorgas D. and Solanki G. The Pott puffy tumor revisited: neuosurgical implications of this unforgotten entity. J Neurosurg (2 Suppl Pediatr) 2006; 105: 143-149.
Patron V, Orsel S, Caire F, Aubry K, Jegoux F. Transethmoidal drainage of frontal brain abscesses. Surg Innov 201. Epub ahead of print.
Pradilla G, Ardila GP, Hsu W and Rigamonti D. Epidural Abscesses of the CNS. Lancet Neurol 2009; 8: 292-300.
Samter’s Triad Asthma
Widal 1922, Samter and Beers 1968 Aspirin Sensitivity Asthma Nasal/ethmoidal polyposis Onset: 20s-30s Possible cross-reaction with NSAIDS Pathophysiology: arachadonic acid cascade
malfunction
Kim et al. 2007