Intestinal Microbial Overgrowth...The Great Plains Laboratory, Inc. Requisition #: Patient Name: Physician: Date of Collection: 4/21/2015 Indicator of Fluid Intake 76 *Creatinine 89

Requisition #:

Patient Name:

Physician:

Date of Collection:

Patient Age:

F

52

Patient Sex:

Time of Collection:

Print Date:

4/21/2015

04:30 AM

04/29/2015

Metabolic Markers in Urine Reference Population - Females Age 13 and Over (mmol/mol creatinine)

Patient Value

Reference Range

Intestinal Microbial Overgrowth

Yeast and Fungal Markers0.90≤1 3.6 0.90Citramalic

5.4≤2 14 5.45-Hydroxymethyl-2-furoic

0≤3 0.33 0.003-Oxoglutaric

10≤4 16 10Furan-2,5-dicarboxylic

0.88≤5 1.9 0.88Furancarbonylglycine

1.5≤6 4.5 1.5Tartaric

88≤ H7 29 88Arabinose

0.36≤8 29 0.36Carboxycitric

0.33≤9 0.44 0.33Tricarballylic

Bacterial Markers622≤ H10 613 622Hippuric

0.55-11 0.660.06 0.552-Hydroxyphenylacetic

1.0≤12 1.3 1.04-Hydroxybenzoic

8.2-13 170.79 8.24-Hydroxyhippuric

0.21≤14 0.38 0.21DHPPA (Beneficial Bacteria)

Clostridia Bacterial Markers25≤ H15 19

(C. difficile, C. stricklandii, C. lituseburense & others)254-Hydroxyphenylacetic

271≤ H16 208(C. sporogenes, C. caloritolerans, C. botulinum & others)

271HPHPA

42≤17 75(C. difficile)

424-Cresol

2.8≤18 11(C. stricklandii, C. lituseburense, C. subterminale & others)

2.83-Indoleacetic

Testing performed by The Great Plains Laboratory, Inc., Lenexa, Kansas. The Great Plains Laboratory has developed and determined the performance characteristics of this test. This test has not been evaluated by the U.S. FDA; the FDA does not currently regulate such testing.

Organic Acids Test - Nutritional and Metabolic Profile Page 1 of 10

The Great Plains Laboratory, Inc.Requisition #:

Patient Name:

Physician:

Date of Collection:

4/21/2015


Patient Value

Reference Range

Oxalate Metabolites

4.6-19 7.00.77 4.6Glyceric

46-20 11716 46Glycolic

69-21 1016.8 69Oxalic

Glycolytic Cycle Metabolites

12≤22 48 12Lactic

4.4≤23 9.1 4.4Pyruvic

Mitochondrial Markers - Krebs Cycle Metabolites

5.3≤24 9.3 5.3Succinic

0.51≤25 0.94 0.51Fumaric

0.95-26 1.80.06 0.95Malic

49≤ H27 35 492-Oxoglutaric

18-28 286.8 18Aconitic

706≤ H29 507 706Citric

Mitochondrial Markers - Amino Acid Metabolites

0.35≤30 0.76 0.353-Methylglutaric

8.8≤ H31 6.2 8.83-Hydroxyglutaric

2.2≤32 4.5 2.23-Methylglutaconic

Neurotransmitter Metabolites

Phenylalanine and Tyrosine Metabolites3.3-33 3.60.80

(dopamine)3.3Homovanillic (HVA)

2.0-34 3.70.46(norepinephrine, epinephrine)

2.0Vanillylmandelic (VMA)

1.6-35 1.80.16 1.6HVA / VMA Ratio

Tryptophan Metabolites1.5≤36 4.3

(serotonin)1.55-Hydroxyindoleacetic (5-HIAA)

2.4-37 3.90.85 2.4Quinolinic

1.4-38 2.20.17 1.4Kynurenic

1.6-39 2.00.42 1.6Quinolinic / 5-HIAA Ratio


The Great Plains Laboratory, Inc.

Requisition #:

Patient Name:

Physician:

Date of Collection: 4/21/2015


Patient Value

Reference Range

Pyrimidine Metabolites - Folate Metabolism

5.1≤40 9.7 5.1Uracil

0.22≤41 0.56 0.22Thymine

Ketone and Fatty Acid Oxidation

19≤ H42 3.1 193-Hydroxybutyric

9.5≤43 10 9.5Acetoacetic

0.34≤44 4.8 0.344-Hydroxybutyric

1.4-45 2.80.44 1.4Ethylmalonic

2.1-46 2.20.10 2.1Methylsuccinic

2.0-47 3.80.04 2.0Adipic

0.80-48 2.20.18 0.80Suberic

0.19≤49 0.24 0.19Sebacic

Nutritional Markers

Vitamin B122.0≤50 2.3 2.0Methylmalonic ä

Vitamin B65.1≤51 34 5.1Pyridoxic (B6)

Vitamin B51.3≤52 10 1.3Pantothenic (B5)

Vitamin B2 (Riboflavin)0.29-53 0.360.04 0.29Glutaric ä

Vitamin C0.44- L54 20010 0.44Ascorbic

Vitamin Q10 (CoQ10)22-55 390.17 223-Hydroxy-3-methylglutaric ä

Glutathione Precursor and Chelating Agent0.17≤56 0.28 0.17N-Acetylcysteine (NAC)

Biotin (Vitamin H)1.9-57 2.70.19 1.9Methylcitric ä

ä A high value for this marker may indicate a deficiency of this vitamin.



Patient Name:

Physician:



Patient Value

Reference Range

Indicators of Detoxification

Glutathione23-58 3310 23Pyroglutamic ä

3.0- H59 1.80.03 3.02-Hydroxybutyric ä

Ammonia Excess0.33-60 0.540.06 0.33Orotic

Aspartame, salicylates, or GI bacteria1.5≤ H61 1.3 1.52-Hydroxyhippuric

ä A high value for this marker may indicate a Glutathione deficiency.

Amino Acid Metabolites

0≤62 0.42 0.002-Hydroxyisovaleric

0.40≤63 2.1 0.402-Oxoisovaleric

0.49≤64 0.87 0.493-Methyl-2-oxovaleric

0≤65 0.48 0.002-Hydroxyisocaproic

0.47≤ H66 0.37 0.472-Oxoisocaproic

0.10≤67 0.16 0.102-Oxo-4-methiolbutyric

0.18≤68 0.21 0.18Mandelic

0.17≤69 0.20 0.17Phenyllactic

0.48-70 1.90.20 0.48Phenylpyruvic

0.04≤71 0.36 0.04Homogentisic

0.72≤72 0.80 0.724-Hydroxyphenyllactic

1.5≤73 3.0 1.5N-Acetylaspartic

3.0≤74 9.7 3.0Malonic

Mineral Metabolism

2 638-75 5 0001 000 2638Phosphoric



Patient Name:

Physician:


Indicator of Fluid Intake

8976 mg/dL *Creatinine

*The creatinine test is performed to adjust metabolic marker results for differences in fluid intake. Urinary creatinine haslimited diagnostic value due to variability as a result of recent fluid intake. Samples are rejected if creatinine is below 20mg/dL unless the client requests results knowing of our rejection criteria.

Example of Elevated Value

Explanation of Report Format

The reference ranges for organic acids were established using samples collected from typical individuals of all ages with no known physiological or psychological disorders. The ranges were determined by calculating the mean and standard deviation (SD) and are defined as + 2SD of the mean. Reference ranges are age and gender specific, consisting of Male Adult (>13 years), Female Adult (>13 years), Male Child (<13 years), and Female Child (<13 years).

There are two types of graphical representations of patient values found in the new report format of both the standard Organic Acids Test and the Microbial Organic Acids Test.

The first graph will occur when the value of the patient is within the reference (normal) range, defined as the mean plus or minus two standard deviations.

The second graph will occur when the value of the patient exceeds the upper limit of normal. In such cases, the graphical reference range is “shrunk” so that the degree of abnormality can be appreciated at a glance. In this case, the lower limits of normal are not shown, only the upper limit of normal is shown.

In both cases, the value of the patient is given to the left of the graph and is repeated on the graph inside a diamond. If the value is within the normal range, the diamond will be outlined in black. If the value is high or low, the diamond will be outlined in red.

Example of Value Within Reference Range


Documents

Intestinal Microbial Overgrowth...The Great Plains Laboratory, Inc. Requisition #: Patient Name: Physician: Date of Collection: 4/21/2015 Indicator of Fluid Intake 76 *Creatinine 89