Interventional Neurology - Global Pipeline Analysis ...Interventional Neurology - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017 Reference Code: GDME0083MAR

GDME0083MAR / Published JUN 2011 Page 1 Interventional Neurology - Global Pipeline Analysis, Competitive

Landscape and Market Forecasts to 2017 © GlobalData. This report is a licensed product and is not to be photocopied

Interventional Neurology - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017

Reference Code: GDME0083MAR Publication Date: June 2011

The Global Interventional Neurology Market is Expected to Grow at a CAGR of XX% from 2010 through 2017

Interventional Neurology Market, Global, Revenue ($m), 2010-2017

2010 2017

Rev

enue

($m

)

CAGR XX%

Source: GlobalData, Boston Scientific Corporation, Johnson & Johnson, Covidien and Terumo Corporation Investors Presentations and Annual Reports, Primary Interviews with Key Opinion Leaders and Industry Participants

The global interventional neurology market is forecast to grow from $XXm in 2010 to $XXm in 2017 at a Compound Annual Growth Rate (CAGR) of XX%. The market expects to grow due to the increasing incidence of aneurysm disease globally. The market is also expected to be driven by increasing treatment options, the sophistication of the procedures available for treatment and improving imaging techniques for the early detection of aneurysms.

Embolic Systems are the Largest Market Segment

The embolic systems market is the largest segment in terms of market size and accounted for almost XX% of total revenue generated in 2010. Navigational systems, neurovascular stents and aneurysm clips were the other three segments of the interventional neurology market in 2010.

The embolic systems segment will continue to witness high growth and remain the largest segment. The global market for embolic systems is forecast to grow from $XXm in 2010 to about $XXm in 2017, at a CAGR of XX%. Development in endovascular treatment procedures, such as embolic coiling, liquid embolic systems and imaging techniques, will drive the global interventional neurology market.

The US is the Biggest Market for Interventional Neurology

Interventional Neurology Market, By Country (%), 2010

The US

Japan

Europe

Others


The US market for interventional neurology was valued at $XXm in 2010 and is forecast to grow at a CAGR of XX% to reach $XXm in 2017. The US is the biggest market in the sector, making up XX% of the global interventional neurology market in 2010. In the US, demand for interventional neurology products is mainly driven by the development of embolization procedures. The market is expected to be driven by the increasing awareness about aneurysm causing diseases and treatment procedures. In the US, navigational systems were the largest market segment, valued at $XXm, in 2010. In 2017, the trend in the market will change and the embolic systems market will grow at a CAGR of XX% to be the largest segment, reaching $XXm.

Shift to Minimally Invasive Treatment is Driving the Interventional Neurology Market

The market is shifting towards minimally invasive treatment and away from surgical treatment options. This is increasing the market value of the endovascular treatment option for aneurysms. Instead of open operations, this minimally invasive technique uses X-ray imaging, catheters, and various embolic systems and neurovascular stents to treat diseases of the blood vessels of the brain and spine. The advantages of coil treatment include the speed of procedure and the use of an endovascular approach rather than craniotomy. This shift is also increasing treatment options for patients with multiple aneurysms, which can now be treated at the same time.



1 Table of contents 1 Table of contents............................................................................................................................. 3

1.1 List of Tables............................................................................................................................. 6 1.2 List of Figures............................................................................................................................ 8

2 Introduction and Overview................................................................................................................ 9 2.1 Introduction ............................................................................................................................... 9 2.2 GlobalData Report Guidance ..................................................................................................... 9

3 Interventional Neurology: Overview ................................................................................................ 10 3.1 Interventional Neurology: Market Segmentation........................................................................ 10

3.1.1 Embolic systems............................................................................................................. 11 3.1.2 Navigational Systems ..................................................................................................... 11 3.1.3 Neurovascular Stents...................................................................................................... 12 3.1.4 Aneurysm Clips .............................................................................................................. 12

4 Aneurysms: Overview.................................................................................................................... 13 4.1 Cerebral Aneurysm.................................................................................................................. 13

4.1.1 Types of Cerebral Aneurysm........................................................................................... 13 4.1.2 Causes........................................................................................................................... 14 4.1.3 Pathophysiology ............................................................................................................. 14 4.1.4 Epidemiology.................................................................................................................. 15 4.1.5 Diagnosis ....................................................................................................................... 15

5 Interventional Neurology: Global Market Characterization ............................................................... 16 5.1 Interventional Neurology Market, Global, Revenue ($m), Historic, 2003-2010............................ 16 5.2 Interventional Neurology Market, Global, Revenue ($m), Forecast, 2010-2017 ......................... 17 5.3 Interventional Neurology Market, Key Trends ........................................................................... 18

5.3.1 Use of Interventional Neurology Products for Treating Other Diseases is a Emerging Trend in the Market .................................................................................................................. 18

5.3.2 Neuroform Stents ........................................................................................................... 19 5.3.3 Liquid Embolic Systems.................................................................................................. 19 5.3.4 Acquisitions of Major Interventional Neurology Companies............................................... 20

5.4 Interventional Neurology, Market Dynamics.............................................................................. 21 5.4.1 Market Drivers................................................................................................................ 21 5.4.2 Interventional Neurology, Market Restraints..................................................................... 23

6 Interventional Neurology Market, Analysis by Segment ................................................................... 25 6.1 Embolic Systems, Market Characterization............................................................................... 25

6.1.1 Embolic Systems Market, Global, Revenue ($m), Historic, 2003-2010.............................. 25 6.1.2 Embolic Systems Market, Global, Revenue ($m), Forecast, 2010-2017 ............................ 26

6.2 Embolic Systems: Market Dynamics......................................................................................... 27 6.2.1 Market Drivers................................................................................................................ 27 6.2.2 Market Restraint ............................................................................................................. 27

6.3 Navigational Systems: Market Characterization ........................................................................ 28 6.3.1 Navigational Systems Market, Global, Revenue ($m), Historic, 2003-2010 ....................... 28 6.3.2 Navigational Systems Market, Global, Revenue ($m), Forecast, 2010-2017 ..................... 29

6.4 Navigational Systems: Market Dynamics.................................................................................. 30 6.4.1 Market Drivers................................................................................................................ 30 6.4.2 Market Restraint: ............................................................................................................ 30

6.5 Neurovascular Stents: Market Characterization ........................................................................ 31 6.5.1 Neurovascular Stents Market, Global, Revenue ($m), Historic, 2003-2010........................ 31 6.5.2 Neurovascular Stents Market, Global, Revenue ($m), Forecast, 2010-2017...................... 32

6.6 Neurovascular Stents: Market Dynamics .................................................................................. 33 6.6.1 Market Driver: Technological Advancements is to Drive the Market .................................. 33 6.6.2 Market Restraint: High Risk associated with Stent to Restrain the Market ......................... 33

6.7 Aneurysm Clips: Market Characterization................................................................................. 34 6.7.1 Aneurysm Clips Market, Global, Revenue ($m), Historic, 2003-2010 ................................ 34 6.7.2 Aneurysm Clips Market, Global, Revenue ($m), Forecast, 2010-2017 .............................. 35

6.8 Aneurysm Clips: Market Dynamics........................................................................................... 36 6.8.1 Market Driver: Cost of Treatment Is Driving the Market .................................................... 36 6.8.2 Market Restraint: Advancements in the Treatment of Aneurysms is a Restraint to the

Clipping Market............................................................................................................... 36 7 Interventional Neurology Market, by Country, Revenue ($m), 2003-2017........................................ 37



7.1 Interventional Neurology Market, The US, Revenue ($m), Historic, 2003-2010 ......................... 37 7.2 Interventional Neurology Market, The US, Revenue ($m), Forecast, 2010-2017 ....................... 38 7.3 Interventional Neurology Market, Canada, Revenue ($m), Historic, 2003-2010......................... 39 7.4 Interventional Neurology Market, Canada, Revenue ($m), Forecast, 2003-2010....................... 40 7.5 Interventional Neurology Market, The UK, Revenue ($m), Historic, 2003-2010 ......................... 41 7.6 Interventional Neurology Market, The UK, Revenue ($m), Forecast, 2010-2017 ....................... 42 7.7 Interventional Neurology Market, Germany, Revenue ($m), Historic, 2003-2010....................... 43 7.8 Interventional Neurology Market, Germany, Revenue ($m), Forecast, 2010-2017..................... 44 7.9 Interventional Neurology Market, France, Revenue ($m), Historic, 2003-2010 .......................... 45 7.10 Interventional Neurology Market, France, Revenue ($m), Forecast, 2010-2017 ........................ 46 7.11 Interventional Neurology Market, Italy, Revenue ($m), Historic, 2003-2010 ............................... 47 7.12 Interventional Neurology Market, Italy, Revenue ($m), Forecast, 2010-2017.............................. 48 7.13 Interventional Neurology Market, Spain, Revenue ($m), Historic, 2003-2010............................. 49 7.14 Interventional Neurology Market, Spain, Revenue ($m), Forecast, 2010-2017 ........................... 50 7.15 Interventional Neurology Market, Japan, Revenue ($m), Historic, 2003-2010 ............................ 51 7.16 Interventional Neurology Market, Japan, Revenue ($m), Forecast, 2010-2017.......................... 52 7.17 Interventional Neurology Market, China, Revenue ($m), Historic, 2003-2010............................. 53 7.18 Interventional Neurology Market, China, Revenue ($m), Forecast, 2010-2017.......................... 54 7.19 Interventional Neurology Market, India, Revenue ($m), Historic, 2003-2010 .............................. 55 7.20 Interventional Neurology Market, India, Revenue ($m), Forecast, 2010-2017 ............................ 56 7.21 Interventional Neurology Market, Australia, Revenue ($m), Historic, 2003-2010........................ 57 7.22 Interventional Neurology Market, Australia, Revenue ($m), Forecast, 2010-2017...................... 58 7.23 Interventional Neurology Market, Brazil, Revenue ($m), Historic, 2003-2010 ............................. 59 7.24 Interventional Neurology Market, Brazil, Revenue ($m), Forecast, 2010-2017 ........................... 60

8 Interventional Neurology Market: Strategic Competitive Assessment ............................................... 61 8.1 Interventional Neurology: Key Market Participants .................................................................... 62

8.1.1 Boston Scientific Corporation .......................................................................................... 62 8.1.2 Johnson & Johnson ........................................................................................................ 65 8.1.3 Covidien plc.................................................................................................................... 68 8.1.4 Terumo Corporation........................................................................................................ 71

9 Interventional Neurology: Key Marketed Products........................................................................... 74 9.1 Neuroform3 Microdelivery Stent System................................................................................... 74

9.1.1 Product Description ........................................................................................................ 74 9.1.2 Features and Benefits..................................................................................................... 74

9.2 Axium Detachable Coil System ................................................................................................ 74 9.2.1 Product Description ........................................................................................................ 74 9.2.2 Features and Benefits..................................................................................................... 74

9.3 Onyx HD-500........................................................................................................................... 75 9.3.1 Product Description ........................................................................................................ 75 9.3.2 Features and Benefits..................................................................................................... 75

9.4 AZUR Peripheral HydroCoil Embolization System .................................................................... 75 9.4.1 Product Description ........................................................................................................ 75 9.4.2 Features and Benefits..................................................................................................... 75

9.5 DELTAPAQ Microcoils............................................................................................................. 76 9.5.1 Product Description ........................................................................................................ 76 9.5.2 Features and Benefits..................................................................................................... 76

10 Interventional Neurology Market: Strategic Pipeline Assessment ..................................................... 77 10.1 Interventional Neurology Products under Clinical Development ................................................. 78

10.1.1 GORE Embolic Filter....................................................................................................... 78 10.1.2 Restore Microcatheter..................................................................................................... 79 10.1.3 PHAROS Vitesse Stent................................................................................................... 80 10.1.4 Neucrylate AN ................................................................................................................ 83 10.1.5 Solitaire FR Revascularization Device ............................................................................. 84 10.1.6 Solitaire AB Neurovascular Remodeling Device............................................................... 88 10.1.7 Transcranial Doppler Ultrasound Device.......................................................................... 88

10.2 Interventional Neurology Products under Early Development .................................................... 88 10.2.1 AIC Catheter .................................................................................................................. 89 10.2.2 Balloon Expandable Stent - Next Generation ................................................................... 89 10.2.3 Catheter Based System .................................................................................................. 89 10.2.4 Covered Stent ................................................................................................................ 89 10.2.5 Flow Diverter .................................................................................................................. 89 10.2.6 Liquid Embolic System.................................................................................................... 89 10.2.7 Neuravi Device ............................................................................................................... 89 10.2.8 Occlusion Balloons ......................................................................................................... 89



10.2.9 Self-Expanding Stent ...................................................................................................... 90 10.2.10 TBI Intervention System.................................................................................................. 90

10.3 Interventional Neurology Products under Pre-Clinical Development........................................... 90 10.3.1 Aneurysm Occlusion Device............................................................................................ 90 10.3.2 Brain Cooling Device ...................................................................................................... 90 10.3.3 Cerebral Aneurysm Repair Device .................................................................................. 90 10.3.4 GP Mechanical Thrombectomy Device............................................................................ 90 10.3.5 NAVIMAX Spiral Balloon Catheter................................................................................... 90 10.3.6 Ultrasound Clot Buster.................................................................................................... 91

10.4 Interventional Neurology Products in Approval Phase............................................................... 91 10.4.1 MicruSphere Microcoil .................................................................................................... 91 10.4.2 Cerecyte Microcoil .......................................................................................................... 93 10.4.3 NeuroFlo Catheter .......................................................................................................... 98 10.4.4 X Calibur Aneurysm Occlusion Device........................................................................... 109 10.4.5 Neucrylate AN .............................................................................................................. 110 10.4.6 Courier Microcatheter ................................................................................................... 111 10.4.7 HeliPaq ........................................................................................................................ 111 10.4.8 HeliPaq SR................................................................................................................... 111 10.4.9 InterPaq Microcoil ......................................................................................................... 111 10.4.10 UltiPaq Microcoil........................................................................................................... 111

11 Interventional Neurology Market: Strategic Deals Analysis ............................................................ 112 11.1 Key Acqusitions..................................................................................................................... 113

11.1.1 Stryker Acquires Boston Scientifics’ Neurovascular Division........................................... 113 11.1.2 Johnson & Johnson Acquires Micrus Endovascular ....................................................... 113 11.1.3 Covidien Completed Acquisition of ev3 for $2.6 Billion ................................................... 114

12 Appendix..................................................................................................................................... 115 12.1 Definitions............................................................................................................................. 116

12.1.1 Interventional Neurology ............................................................................................... 116 12.1.2 Embolic Systems.......................................................................................................... 116 12.1.3 Navigational Systems ................................................................................................... 116 12.1.4 Neurovascular Stents.................................................................................................... 116 12.1.5 Aneurysm Clips ............................................................................................................ 116

12.2 Acronyms.............................................................................................................................. 117 12.3 Sources ................................................................................................................................ 117 12.4 Research Methodology.......................................................................................................... 118 12.5 Secondary Research ............................................................................................................. 118 12.6 Primary Research.................................................................................................................. 118 12.7 Models.................................................................................................................................. 119 12.8 Forecasts.............................................................................................................................. 119 12.9 GlobalData Consulting........................................................................................................... 119 12.10Contact Us............................................................................................................................ 120 12.11Disclaimer............................................................................................................................. 120



1.1 List of Tables Table 1: Interventional Neurology Market, Global, Revenue ($m), 2003-2010..................................... 16 Table 2: Interventional Neurology Market, Global, Revenue ($m), 2010-2017..................................... 17 Table 3: Major Acquisitions in Interventional Neurology Market.......................................................... 20 Table 4: Embolic Systems Market, Global, Revenue ($m), 2003-2010 ............................................... 25 Table 5: Embolic Systems Market, Global, Revenue ($m), 2010-2017 ............................................... 26 Table 6: Navigational Systems Market, Global, Revenue ($m), 2003-2010......................................... 28 Table 7: Navigational Systems Market, Global, Revenue ($m), 2010-2017......................................... 29 Table 8: Neurovascular Stents Market, Revenue ($m), 2003-2010..................................................... 31 Table 9: Neurovascular Stents Market, Revenue ($m), 2010-2017..................................................... 32 Table 10: Aneurysm Clips Market, Global, Revenue ($m), 2003-2010.................................................. 34 Table 11: Aneurysm Clips Market, Global, Revenue ($m), 2010-2017.................................................. 35 Table 12: Interventional Neurology Market, The US, Revenue ($m), 2003-2010................................... 37 Table 13: Interventional Neurology Market, The US, Revenue ($m), 2010-2017................................... 38 Table 14: Interventional Neurology Market, Canada, Revenue ($m), 2003-2010 .................................. 39 Table 15: Interventional Neurology Market, Canada, Revenue ($m), 2010-2017 .................................. 40 Table 16: Interventional Neurology Market, the UK, Revenue ($m), 2003-2010.................................... 41 Table 17: Interventional Neurology Market, The UK, Revenue ($m), 2010-2017................................... 42 Table 18: Interventional Neurology Market, Germany, Revenue ($m), 2003-2010 ................................ 43 Table 19: Interventional Neurology Market, Germany, Revenue ($m), 2010-2017 ................................ 44 Table 20: Interventional Neurology Market, France, Revenue ($m), 2003-2010.................................... 45 Table 21: Interventional Neurology Market, France, Revenue ($m), 2010-2017.................................... 46 Table 22: Interventional Neurology Market, Italy, Revenue ($m), 2003-2010 ........................................ 47 Table 23: Interventional Neurology Market, Italy, Revenue ($m), 2010-2017 ........................................ 48 Table 24: Interventional Neurology Market, Spain, Revenue ($m), 2003-2010...................................... 49 Table 25: Interventional Neurology Market, Spain, Revenue ($m), 2010-2017...................................... 50 Table 26: Interventional Neurology Market, Japan, Revenue ($m), 2003-2010 ..................................... 51 Table 27: Interventional Neurology Market, Japan, Revenue ($m), 2010-2017 ..................................... 52 Table 28: Interventional Neurology Market, China, Revenue ($m), 2003-2010 ..................................... 53 Table 29: Interventional Neurology Market, China, Revenue ($m), 2010-2017 ..................................... 54 Table 30: Interventional Neurology Market, India, Revenue ($m), 2003-2010....................................... 55 Table 31: Interventional Neurology Market, India, Revenue ($m), 2010-2017....................................... 56 Table 32: Interventional Neurology Market, Australia, Revenue ($m), 2003-2010 ................................. 57 Table 33: Interventional Neurology Market, Australia, Revenue ($m), 2010-2017 ................................. 58 Table 34: Interventional Neurology Market, Brazil, Revenue ($m), 2003-2010...................................... 59 Table 35: Interventional Neurology Market, Brazil, Revenue ($m), 2010-2017...................................... 60 Table 36: Interventional Neurology Market, Company Share (%), 2010................................................ 61 Table 37: Boston Scientific Corporation, Marketed Products................................................................ 62 Table 38: Johnson and Johnson, Marketed Products .......................................................................... 65 Table 39: Johnson & Johnson, Pipeline Products................................................................................ 66 Table 40: Covidien, Inc, Marketed Products ........................................................................................ 68 Table 41: Covidien, Inc, Pipeline Products .......................................................................................... 68 Table 42: Terumo Corporation, Marketed Products ............................................................................. 71 Table 43: Neuroform Microdelivery Stent System, Features and Benefits............................................. 74 Table 44: Axium Detachable Coil System, Features and Benefits ........................................................ 74 Table 45: Onyx HD-500, Features and Benefits .................................................................................. 75 Table 46: AZUR Peripheral HydroCoil Embolization System, Features and Benefits............................. 75 Table 47: DELTAPAQ Microcoils, Features and Benefits..................................................................... 76 Table 48: Interventional Neurology, Products Under Clinical Development, 2011 ................................. 78 Table 49: GORE Embolic Filter, Product Status, 2011......................................................................... 78 Table 50: GORE Embolic Filter, Clinical Trials, 2011........................................................................... 79 Table 51: Restore Microcatheter, Product Status, 2011....................................................................... 79 Table 52: Restore Microcatheter, Clinical Trial, 2011........................................................................... 80 Table 53: PHAROS Vitesse Stent, Product Status, 2011 ..................................................................... 80 Table 54: PHAROS Vitesse Stent, Clinical Trial, 2011......................................................................... 81 Table 55: Neucrylate AN, Product Status, 2011................................................................................... 83 Table 56: Neucrylate AN, Clinical Trial, 2011 ...................................................................................... 83 Table 57: Solitaire FR Revascularization Device, Product Status, 2011................................................ 84 Table 58: Solitaire FR Revascularization Device, Clinical Trial (0), 2011 .............................................. 85 Table 59: Solitaire FR Revascularization Device, Clinical Trial (1), 2011 .............................................. 86 Table 60: Interventional Neurology, Products Under Early Development, 2011..................................... 88 Table 61: Interventional Neurology, Products Under Pre-Clinical Development, 2011........................... 90



Table 62: Interventional Neurology, Products in Approval Phase, 2011................................................ 91 Table 63: MicruSphere Microcoil, Product Status, 2011....................................................................... 91 Table 64: MicruSphere Microcoil, Clinical Trials, 2011......................................................................... 92 Table 65: Cerecyte Microcoil, Clinical Trial(0), 2011 ............................................................................ 93 Table 66: Cerecyte Microcoil, Clinical Trial(1), 2011 ............................................................................ 94 Table 67: Cerecyte Microcoil, Clinical Trial(2), 2011 ............................................................................ 95 Table 68: Cerecyte Microcoil, Clinical Trial(3), 2011 ............................................................................ 96 Table 69: Cerecyte Microcoil, Clinical Trial(4), 2011 ............................................................................ 97 Table 70: NeuroFlo Catheter, Product Status, 2011............................................................................. 98 Table 71: NeuroFlo Catheter, Clinical Trial (0), 2011 ........................................................................... 99 Table 72: NeuroFlo Catheter, Clinical Trial (1), 2011 ......................................................................... 100 Table 73: NeuroFlo Catheter, Clinical Trial (2), 2011 ......................................................................... 101 Table 74: NeuroFlo Catheter, Clinical Trial (3), 2011 ......................................................................... 103 Table 75: NeuroFlo Catheter, Clinical Trial (4), 2011 ......................................................................... 103 Table 76: NeuroFlo Catheter, Clinical Trial (5), 2011 ......................................................................... 105 Table 77: NeuroFlo Catheter, Clinical Trial (6), 2011 ......................................................................... 106 Table 78: NeuroFlo Catheter, Clinical Trial (7), 2011 ......................................................................... 107 Table 79: NeuroFlo Catheter, Clinical Trial (8), 2011 ......................................................................... 108 Table 80: X Calibur Aneurysm Occlusion Device, Product Status, 2011............................................. 110 Table 81: X Calibur Aneurysm Occlusion Device, Clinical Trials, 2011 ............................................... 110 Table 82: Neucrylate AN, Product Status, 2011................................................................................. 111 Table 83: Interventional Neurology Market, Deal Value ($m) and Volume, 2004 – 2010 ..................... 112



1.2 List of Figures Figure 1: Interventional Neurology, Market Segmentation................................................................... 10 Figure 2: Embolization Coils Procedure.............................................................................................. 11 Figure 3: Aneurysm Clipping Procedure............................................................................................. 12 Figure 4: Types of Cerebral Aneurysms ............................................................................................. 13 Figure 5: Cerebral Aneurysm, Pathophysiology.................................................................................. 14 Figure 6: Cerebral Aneurysm, Disease Burden, 2008 ......................................................................... 15 Figure 7: Interventional Neurology Market, Global, Revenue ($m), 2003-2010..................................... 16 Figure 8: Interventional Neurology Market, Global, Revenue ($m), 2010-2017..................................... 17 Figure 9: Interventional Neurology Treatment, by Disease .................................................................. 18 Figure 10: Interventional Neurology, Market Dynamics ......................................................................... 21 Figure 11: Embolic Systems Market, Global, Revenue ($m), 2003-2010 ............................................... 25 Figure 12: Embolic Systems Market, Global, Revenue ($m), 2010-2017 ............................................... 26 Figure 13: Navigational Systems Market, Global, Revenue ($m), 2003-2010......................................... 28 Figure 14: Navigational Systems Market, Global, Revenue ($m), 2010-2017......................................... 29 Figure 15: Neurovascular Stents Market, Revenue ($m), 2003-2010..................................................... 31 Figure 16: Neurovascular Stents Market, Revenue ($m), 2010-2017..................................................... 32 Figure 17: Aneurysm Clips Market, Global, Revenue ($m), 2003-2010.................................................. 34 Figure 18: Aneurysm Clips Market, Global, Revenue ($m), 2010-2017.................................................. 35 Figure 19: Interventional Neurology Market, The US, Revenue ($m), 2003-2010................................... 37 Figure 20: Interventional Neurology Market, The US, Revenue ($m), 2010-2017................................... 38 Figure 21: Interventional Neurology Market, Canada, Revenue ($m), 2003-2010................................... 39 Figure 22: Interventional Neurology Market, Canada, Revenue ($m), 2010-2017................................... 40 Figure 23: Interventional Neurology Market, The UK, Revenue ($m), 2003-2010................................... 41 Figure 24: Interventional Neurology Market, The UK, Revenue ($m), 2010-2017................................... 42 Figure 25: Interventional Neurology Market, Germany, Revenue ($m), 2003-2010 ................................ 43 Figure 26: Interventional Neurology Market, Germany, Revenue ($m), 2010-2017 ................................ 44 Figure 27: Interventional Neurology Market, France, Revenue ($m), 2003-2010.................................... 45 Figure 28: Interventional Neurology Market, France, Revenue ($m), 2010-2017.................................... 46 Figure 29: Interventional Neurology Market, Italy, Revenue ($m), 2003-2010 ........................................ 47 Figure 30: Interventional Neurology Market, Italy, Revenue ($m), 2010-2017 ........................................ 48 Figure 31: Interventional Neurology Market, Spain, Revenue ($m), 2003-2010...................................... 49 Figure 32: Interventional Neurology Market, Spain, Revenue ($m), 2010-2017...................................... 50 Figure 33: Interventional Neurology Market, Japan, Revenue ($m), 2003-2010 ..................................... 51 Figure 34: Interventional Neurology Market, Japan, Revenue ($m), 2010-2017 ..................................... 52 Figure 35: Interventional Neurology Market, China, Revenue ($m), 2003-2010...................................... 53 Figure 36: Interventional Neurology Market, China, Revenue ($m), 2010-2017...................................... 54 Figure 37: Interventional Neurology Market, India, Revenue ($m), 2003-2010....................................... 55 Figure 38: Interventional Neurology Market, India, Revenue ($m), 2010-2017....................................... 56 Figure 39: Interventional Neurology Market, Australia, Revenue ($m), 2003-2010 ................................. 57 Figure 40: Interventional Neurology Market, Australia, Revenue ($m), 2010-2017 ................................. 58 Figure 41: Interventional Neurology Market, Brazil, Revenue ($m), 2003-2010...................................... 59 Figure 42: Interventional Neurology Market, Brazil, Revenue ($m), 2010-2017...................................... 60 Figure 43: Interventional Neurology Market, Company Share (%), 2010................................................ 61 Figure 44: Boston Scientific, SWOT Analysis ....................................................................................... 63 Figure 45: Johnson & Johnson, SWOT Analysis................................................................................... 66 Figure 46: Covidien, Inc, SWOT Analysis............................................................................................. 69 Figure 47: Terumo Corporation, SWOT Analysis .................................................................................. 72 Figure 48: Interventional Neurology Market, Global Pipeline Products................................................... 77 Figure 49: Interventional Neurology Market, Deal Value ($m) and Volume, 2004 – 2010...................... 112



2 Introduction and Overview

2.1 Introduction Interventional neurology is a medical science technology specialized in minimally invasive image based technology and procedures used for treating aneurysms of the head, neck or spine. This technology can also be used for diagnosis. The procedures are designed to be minimally invasive, reducing the risks for the patient and decreasing the time required for recovery. Interventional neurology provides a number of options for treatment, such as clipping, coiling and stenting.

The interventional neurology market is a large market that is growing every year. This growth is due to the advances in technology used for treatment. There is a shift towards minimal invasive treatment, which is as a major driver for the growing market.

2.2 GlobalData Report Guidance The report includes an executive summary, which captures the key points driving and restraining

growth in the global interventional neurology market.

The disease overview: pathophysiology, epidemiology and diagnosis chapter provides a disease overview for cerebral aneurysms.

The market characterization chapter provides information on the global market size from 2003 through 2017. The chapter also details the market trends, drivers and restraints affecting the market.

The country analysis and forecasts chapter provides market analysis and forecast information for 12 countries: the US, Canada, the UK, Germany, France, Spain, Italy, Australia, Japan, Brazil, China and India, for 2003 through 2017.

The strategic competitive assessment chapter discusses the competitive landscape of the interventional neurology market. It also includes profiles of the key players in the market.

The key marketed products chapter provides information on the key approved products in the interventional neurology market.

The pipeline assessment chapter provides information on the pipeline products for interventional neurology market, and provides profiles for the key pipeline products.

The deals landscape chapter discusses mergers and acquisitions in the global interventional neurology market for 2007 through 2010. Some of the deals that took place during the period are discussed in detail.



5 Interventional Neurology: Global Market Characterization

5.1 Interventional Neurology Market, Global, Revenue ($m), Historic, 2003-2010

Figure 7: Interventional Neurology Market, Global, Revenue ($m), 2003-2010

2003 2004 2005 2006 2007 2008 2009 2010

Rev

enue

($m

)


Table 1: Interventional Neurology Market, Global, Revenue ($m), 2003-2010

2003 2004 2005 2006 2007 2008 2009 2010 CAGR 2003-2010

Interventional Neurology


The global interventional neurology market was valued at $XXm in 2010 and grew at a CAGR of XX% from 2003 through 2010. The market has been driven by technology such as embolic systems and neurovascular stents. Increasing knowledge of the symptoms of aneurysms and related diseases among patients has increased the market potential of these devices.



8 Interventional Neurology Market: Strategic Competitive Assessment Figure 43: Interventional Neurology Market, Company Share (%), 2010

Johnson & Johnson

Covidien plc

Terumo Corporation

OthersBoston Scientific

Corporation


Table 36: Interventional Neurology Market, Company Share (%), 2010

Company Name Revenue ($m)

Boston Scientific Corporation

Johnson & Johnson

Covidien plc

Terumo Corporation

Others


In 2010, Boston Scientific Corporation with a XX% share was the leading player in the global interventional neurology market. Johnson & Johnson (XX%), Covidien (XX%) and Terumo Corporation (XX%) also had significant presence. The global market for interventional neurology has a lot of small players such as Mizuho Ikakogyo Co., Ltd., BioCure and PLS Precision Electronic Technology Co., Ltd which affects the market share of the leading companies.

The global interventional neurology market has seen significant changes in the competitive landscape in the past few years. This change is due to the acquisitions of leading companies. In July 2010, eV3 was acquired by Covidien, this transaction benefited Covidien by providing a good position and an accountable share of the market. In September 2010, Micrus was acquired by Johnson & Johnson to become part of Codman Neurovascular products operated by DePuy, Inc.



12 Appendix The data and analysis within this report is driven by the Medical eTrack

Medical eTrack gives you key information to drive the sales, investment and deal making activity of your business. It includes the following information:

14,000+ Market size data tables across 400 medical equipment segments and 37 countries with historic data from 2000 forecast to 2016

3,000+ Primary expert interviews conducted to ensure data and report quality

1,000+ Conferences on the medical equipment covered

1,000+ Industry leading reports covering growing sectors, market trends, investment opportunities and the competitive landscape

450+ Analysis reports covering market and pipeline product analysis reports by indication, medical equipment trends and issue reports and investment and M&A trend reports worth over $3m

20,000+ Medical equipment companies profiled

1,500+ Private, emerging and technology start-up company profiles

1,000+ Medical equipment manufacturers in China and India

1,500+ Medical equipment companies in Japan

450+ Companies with revenue splits and market shares by category

500+ Quarterly and annual medical equipment company financials

400+ Medical equipment company SWOTs

7,000+ Pipeline product profiles

4,000+ Marketed product profiles

1,500+ Pipeline technologies

10,500+ Clinical trials

12,000+ Trial investigators

9,000+ New product patents

2,500+ Companies with products in development

12,000+ Deals in the medical equipment industry

1,100+ Surgical and diagnostic procedures by therapy area

40+ Key healthcare indicators by country

For more information or to receive a free demo of the service visit

http://www.medicaletrack.com/contactus.aspx?RD=Demo



12.1 Definitions 12.1.1 Interventional Neurology Interventional neurology includes devices for the treatment of intracranial aneurysms. This market includes devices used during the treatment of aneurysms

12.1.2 Embolic Systems Embolic systems include devices used to treat aneurysms and other blood vessel malformations called fistulas that occur in the brain. It comprises embolization coils and liquid embolic systems.

12.1.2.1 Embolization Coils

Embolisation coils are soft platinum wires which are inserted in the blood vessel and placed at the site of vessel malformation. The body responds by forming blood clots around the coil(s), which helps block the flow of blood into the bulge or passageway and keep the vessel from rupturing or leaking. One unit means one embolization coil.

12.1.2.2 Liquid Embolic Systems

Liquid embolic systems includes fluids used for therapeutic embolization and are administered via a pre-positioned microcatheter under continuous fluoroscopic monitoring. The segment includes cyanoacrylates and other embolic agents, which act by polymerization or precipitation. One unit means one 1ml liquid embolic vial.

12.1.3 Navigational Systems Navigational systems include devices that use percutaneous catheter technology and radiological imaging in treating diseases of the head and neck, spine and the central nervous system. It comprises guidewires, navigational catheters and PTA Balloons used specifically for intracranial navigation.

12.1.3.1 Guidewires

Guidewires are intended for general intravascular use, including neurovascular vasculature. It is used to selectively introduce and position catheters and other interventional devices within the neurovasculature. They are mainly used in the treatment of brain aneurysms. One unit consists of a single guidewire.

12.1.3.2 Navigational Catheters

Navigation catheters are used to assist the delivery of therapeutic agents and diagnostic agents, such as occlusion coils and contrast media into the neurovasculature. They are mainly used in the treatment of brain aneurysms. One unit consists of a single catheter.

12.1.4 Neurovascular Stents Neurovascular stents are small, metal mesh tubes used to support the walls of the arteries that have narrowed within the neck or the brain. One stent is considered as one unit.

12.1.5 Aneurysm Clips An aneurysm clip is a fabricated predetermined length of round metallic rod or wire used to isolate an aneurysm from the normal circulation without blocking off any small perforating arteries nearby. The clip works such as a tiny coil-spring clothespin, in which the blades of the clip remain tightly closed until pressure is applied to open the blades. Clips are made of titanium and remain on the artery permanently. One unit is one aneurysm clip



12.2 Acronyms ANDA: Abbreviated New Drug Applications

AVM: Arteriovenous Malformation

AWP: Average Wholesale Price

CAGR: Compounded Annual Growth Rate

CT: Computed Tomography

DMSO: Dimethyl Sulfoxide

EVOH: Ethylene Vinyl Alcohol

IDE: Investigational Device Exemption

ISAT: International Subarachnoid Aneurysm Trial

MRI: Magnetic Resonance Imaging

PGA: Poly Glycolic Acid

PMA: Premarket Approval

PTFE: Polytetrafluro ethylene

SAH: Subarachnoid Hemorrhage

SFA: Superficial Femoral Artery

UCAS: Unruptured Cerebral Aneurysm Study

12.3 Sources American Academy of Family Physicians

American Neurological Association

American Stroke Association

Articles on Interventional Neurology

Asian and Oceanian Association of Neurology

Australian and New Zealand College of Anaesthetists

Brain Aneurysm Foundation

British Medical Journal

Canadian Neurological Sciences Federation

Clinical Trials.gov

Company Annual Reports, Quarterly Reports, SEC Filings

Congress Medical Congress

International Journal of Robotics Research

Japanese Society of neurology

Massachusetts General Hospitals

Mayfield

Medscape

National Institute of Neurological Disorders and stroke

Neurology Society of India



PubMed

12.4 Research Methodology GlobalData’s dedicated research and analysis teams consist of qualified professionals with experience in marketing, market research, consultancy (with a background in the medical devices industry) and advanced statistical expertise.

GlobalData adheres to the codes of practice of the Market Research Society (www.mrs.org.uk) and the Society of Competitive Intelligence Professionals (www.scip.org).

All GlobalData databases are continuously updated and revised. The following research methodology is followed for all databases and reports.

12.5 Secondary Research The research process begins with exhaustive secondary research of internal and external sources to provide qualitative and quantitative information relating to each market.

The secondary research sources that are typically referred to include, but are not limited to:

Company websites, annual reports, financial reports, broker reports, investor presentations and SEC filings

Industry trade journals, scientific journals and other technical literature

Internal and external proprietary databases

Relevant patent and regulatory databases

National government documents, statistical databases and market reports

Procedure registries

News articles, press releases and web-casts specific to the companies operating in the market

12.6 Primary Research GlobalData conducts hundreds of primary interviews a year with industry participants and commentators in order to validate its data and analysis. A typical research interview fulfills the following functions:

Provides first-hand information on the market size, market trends, growth trends, competitive landscape and future outlook

Helps in validating and strengthening the secondary research findings

Further develops the analysis team’s expertise and market understanding.

Primary research involves telephone and email interviews as well as face-to-face interviews for each market, category, segment and sub-segment across geographies.

The participants who typically take part in the process include, but are not limited to:

Industry participants: CEOs, VPs, marketing/product managers, market intelligence managers and national sales managers

Hospital stores, laboratories, pharmacies, distributors and paramedics

Outside experts: investment bankers, valuation experts, and research analysts specializing in specific medical equipment markets

Key opinion leaders: physicians and surgeons specializing in different therapeutic areas corresponding to different kinds of medical equipment.



12.7 Models Where no hard data is available, GlobalData uses modeling and estimates in order to produce comprehensive data sets. The following rigorous methodology is adopted:

Available hard data is cross referenced with the following data types to produce estimates:

Demographic data: population, split by segment

Macro-economic indicators: such as GDP and inflation rate

Healthcare indicators: health expenditure, physicians base, healthcare infrastructure and facilities

Selected epidemiological and procedure statistics

Data is then cross checked by the expert panel. All data and assumptions related to modeling are stored and are available to clients on request.

12.8 Forecasts GlobalData uses proprietary forecast models. The following four factors are utilized in the forecast models:

Historic growth rates

Macro indicators such as population trends and healthcare spending

Forecast epidemiological data

Qualitative trend information and assumptions

Data is then cross checked by the expert panel.

Expert Panel

GlobalData uses a panel of experts to cross verify its databases and forecasts.

GlobalData’s expert panel includes marketing managers, product specialists, international sales managers from medical device companies, academics from research universities, KOLs from hospitals, consultants from venture capital firms and distributors/suppliers of medical equipment and supplies.

Historic data and forecasts are relayed to GlobalData’s expert panel for feedback and adjusted accordingly.

12.9 GlobalData Consulting We hope that the data and analysis in this brief will help you make informed and imaginative business decisions. If you have further requirements, GlobalData’s consultancy team may be able to help you. GlobalData offers tailor made analytical and advisory services to drive your key strategic decisions.



12.11 Disclaimer All Rights Reserved.

No part of this publication may be reproduced, stored in a retrieval system or transmitted in any form by any means, electronic, mechanical, photocopying, recording or otherwise, without the prior permission of the publisher, GlobalData.

Documents

Interventional Neurology - Global Pipeline Analysis ...Interventional Neurology - Global Pipeline Analysis, Competitive Landscape and Market Forecasts to 2017 Reference Code: GDME0083MAR