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7/23/2019 Interpretation of Serologic Test Results for HBV Infection
http://slidepdf.com/reader/full/interpretation-of-serologic-test-results-for-hbv-infection 1/1
Interpretation of serologic test results for HBV infection
HBsAg
Total
anti-
HBc
IgM
anti-
HBc
Anti-
HBsInterpretation
– – – – Never infected / Susceptible (consider vaccination)
+ – – – Early acute infection; early incubation; transient (up to 18 days) after
vaccination
+ + +* – Acute infection
– + + – Acute resolving infection
– + – + Recovered from past infection and immune (due to natural infection)
+ + –/+**
– Chronic infection
– + – –
Past infection (resolved infection or resolving acute infection); false positive
(i.e., susceptible); “low-level” (occult) chronic infection; passive transfer to
infant born to HBsAg-positive mother
– – – +Immune (due to hepatitis B vaccination) if concentration is >10 mIU/mL,
passive transfer after HBIG administration
*High titre
**Anti-HBc IgM can also be present (usually at a lower titre) in a flare of chronic hepatitis B
Source: https://ntp.niehs.nih.gov/ntp/newhomeroc/roc11/hbv_rg2public_508.pdf
(p. 21)
http://clinipathpathology.com.au/media/77501/hepatitis%20serological%20testing.pdf (p.3)