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Interpretation of Serologic Test Results for HBV Infection

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Page 1: Interpretation of Serologic Test Results for HBV Infection

7/23/2019 Interpretation of Serologic Test Results for HBV Infection

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Interpretation of serologic test results for HBV infection

HBsAg

Total

anti-

HBc

IgM

anti-

HBc

Anti-

HBsInterpretation

 –   –   –   –  Never infected / Susceptible (consider vaccination)

+  –   –   – Early acute infection; early incubation; transient (up to 18 days) after

vaccination

+ + +*  –  Acute infection

 –  + +  –  Acute resolving infection

 –  +  –  + Recovered from past infection and immune (due to natural infection)

+ +  –/+**

   –  Chronic infection

 –  +  –   – 

Past infection (resolved infection or resolving acute infection); false positive

(i.e., susceptible); “low-level” (occult) chronic infection; passive transfer to

infant born to HBsAg-positive mother

 –   –   –  +Immune (due to hepatitis B vaccination) if concentration is >10 mIU/mL,

passive transfer after HBIG administration

*High titre

**Anti-HBc IgM can also be present (usually at a lower titre) in a flare of chronic hepatitis B

Source: https://ntp.niehs.nih.gov/ntp/newhomeroc/roc11/hbv_rg2public_508.pdf  

(p. 21)

http://clinipathpathology.com.au/media/77501/hepatitis%20serological%20testing.pdf  (p.3)