INTERNATIONAL QUALITY ASSURANCE PROGRAMME (IQAP) … · 2013. 10. 9. · CWOOM9 codeine, morphine, 6-mam CZJD27 morphine, codeine D7TTWV OPIÁCEOS DONO2Y 6-MAM, codeine, morphine

INTERNATIONAL QUALITY ASSURANCE PROGRAMME (IQAP)

INTERNATIONAL COLLABORATIVE EXERCISES (ICE)

Summary ReportBIOLOGICAL SPECIMENS

2013/1

Samples Substances Concentrations Comments on substancesSample 1 Morphine (Total) 2300 ng/ml

6-Monoacetylmorphine (6-MAM) 576 ng/ml

Codeine 1150 ng/ml

Sample 2 Nordazepam 1727 ng/ml

Oxazepam 457 ng/ml

Amfetamine 1143 ng/ml

Temazepam 464 ng/ml

Sample 3 gamma-Hydroxybutyric acid (GHB) 14427 ng/ml

Sample 4 [blank sample]

Test Samples Information

Samples Comments on samplesSample 1 To prepare BS-1, urine was spiked with Morphine sulphate (3057ng/ml, 2300ng base/ml), Codeine

(1150ng base/ml) and 6-Monoacetylmorphine (576 ng base/ml). The spiked urine was dispensed in 50ml aliquots and lyophilised.

Sample 2 To prepare BS-2, urine was spiked with Amfetamine sulfate (1562ng/ml, 1143ng base/ml), Nordazepam (1727ng/ml), Oxazepam (457ng/ml) and Temazepam (464ng/ml). The spiked urine was dispensed in 50ml aliquots and lyophilised.

Sample 3 To prepare BS-3, urine was spiked with Sodium gammahydroxybutyrate (14427ng GHB/ml, ). The spiked urine was dispensed in 50ml aliquots and lyophilised

Sample 4 BS-4 was a blank test sample prepared from urine containing no substance in the ICE menu. The sample contained urine spiked with Ephedrine hydrochloride (2700ng/ml, 2308ng base/ml). The spiked urine was dispensed in 50ml aliquots and lyophilised.

2013/1-BS Copyright (c) 2013 UNODC(2)

INTERNATIONAL QUALITY ASSURANCE PROGRAMME (IQAP)INTERNATIONAL COLLABORATIVE EXERCISES (ICE)

Table of contents Introduction Page 3 Comments from the International Panel of Forensic Experts Page 3

Codes and Abbreviations Page 4 Sample 1 Analysis Page 5 Identified substances Page 5

Statement of findings Page 7 Identification methods Page 11

Summary Page 13 Z-Scores Page 14 Sample 2 Analysis Page 18 Identified substances Page 18

Statement of findings Page 20 Identification methods Page 24

Summary Page 26 Z-Scores Page 27

Sample 3 Analysis Page 33 Identified substances Page 33

Statement of findings Page 34 Identification methods Page 38 Summary Page 40

Z-Scores Page 41

Sample 4 Analysis Page 43 Identified substances Page 43

Statement of findings Page 44 Identification methods Page 48 Summary Page 50

Introduction

An important element of the UNODC International Quality Assurance Programme (IQAP) is the implementation of the International Collaborative Exercises (ICE). The exercises allow laboratories, from both developing and developed countries, to continuously monitor their performance in drug testing on a truly global scale. Two rounds are offered per year with each round presenting participants with four different test samples for analysis.

This report provides information on the analytical results of laboratories participating in the Biological Specimens (BS) group. In order to maintain confidentiality, the participating laboratories have been assigned random “Web Codes”, which change every round. The analytical results returned by laboratories participating in ICE are evaluated by UNODC and a confidential report is provided to each laboratory on its own performance. The overall analytical results are reviewed by the UNODC’s International Panel of Forensic Experts which oversees the implementation of these exercises, and offers guidance and support in addressing relevant quality issues. The exercises provide an overview of the performance and capacity of participating laboratories and enable UNODC to tailor technical support in the laboratory sector for greatest impact.

Comments from the International Panel of Forensic Experts

Participation of laboratories

Samples within both the Seized materials (SM) and Biological Specimens (BS) test group were sent to 167 laboratories in 57 countries. 68 laboratories participated in the BS test group and 58 (85%) laboratories submitted the results of their analysis in time for inclusion in the summary report, with 96% using the ICE portal for return of results. The almost universal usage of the ICE portal continues to be a high endorsement of its utility.

Qualitative and Quantitative Analysis of the biological specimens test samples

Overall, the level of performance in identification of the test samples was good given the inherently higher level of difficulty in the analysis of biological specimens compared to seized materials. The complexity of the test samples in ICE 2013/1 was increased in order to challenge the participants. BS-1 contained morphine, 6-monoacetylmorphine and codeine, which were identified by 79%, 79% and 91% of participants respectively. It is encouraging to note that 71% of participants identified all three components in BS-1 and only five false positive results were reported. BS-2 contained amphetamine and a mixture of three benzodiazepines (nordazepam, oxazepam and temazepam). While only 42% of participants identified all four components, 86% identified at least one of the benzodiazepines and 65% identified the amphetamine present. There were eight false positive results including four for diazepam. While the benzodiazepines present are metabolites of diazepam, their presence alone does not represent use of diazepam. BS-3 contained gammahydroxybutyric acid (GHB), a new substance on the ICE menu for the BS test group and 22% of participants identified its presence, while 64% of participants did not carry out analysis for identification of GHB. It is recognized that while GHB may not be commonly analysed by all participants, it has been included in the ICE menu as it represents an example of a more recently abused substance and at the Commission on Narcotic Drugs in March 2013, GHB was transferred from schedule IV to schedule II of the Convention of Psychotropic Substances of 1971. BS-4 was a blank test sample containing no substances from the ICE menu. Although it did contain ephedrine, a precursor to methamphetamine. 19% of participants identified the ephedrine and among five false positives, there was one for methamphetamine.

The results for quantitative analysis within the BS test group were excellent. For BS-1 24 out of 25 (96%) laboratories quantified the morphine, 21 out of 22 (95%) quantified 6-MAM and 22 out of 23 (96%) quantified codeine with acceptable Z-scores. Within BS-2, the quantitation results were equally as good with 20 of 21 (95%) laboratories quantifying the amfetamine, 20 out of 22 (91%) the nordazepam, 13 of 16 (81%) the oxazepam and 14 out of 16 (88%) the temazepam with acceptable Z-scores. Within BS-3, 7 out of 9 (87%) participants quantified the GHB present with acceptable Z-scores. It is encouraging to note that of those laboratories who did carry out quantification, 52% performed quantification on at least seven of the eight substances in all test samples. The predominant analytical techniques used by participants for quantification within the BS test group were GC/MS (79%), followed by LC/MS (38%) and others at (17%).

Laboratories are encouraged to carry out quantification as it can improve the quality of laboratory analyses and can be helpful in assessing the significance of the results. Also, laboratories reporting false positive or false negative results should investigate the reasons for this and corrective actions should be taken in order to continuously improve performance. Participation in ICE also helps in monitoring the effect of corrective actions.

(3)

Codes and Abbreviations

Tech Code Name100 Agglutination Techniques

110 Enzyme Immunoassay Techniques

120 Fluorescence Polarization Immunoassay

130 Radioimmunoassay

140 Colorimetric reactions

141 Marquis reagent (sulphuric acid, formaldehyde)

142 Cobalt thiocyanate

150 Thin Layer Chromatography

160 High/Ultra High Performance Liquid Chromatography

161 High Performance Liquid Chromatography with diode array detection

170 Gas Chromatography NPD

171 Gas Chromatography FID

172 Gas Chromatography ECD

180 Gas Chromatography/Mass Spectrometry

190 Fourier Transform Infrared Spectrometry

200 Spectrophotometry (visible, UV)

210 Others (specify)

211 NMR

220 Microcrystal test

230 Liquid chromatography/mass spectrometry

231 Liquid chromatography/tandem mass spectrometry

(+) “positive”: Indicates that the analyte is identified; for presumptive tests (e.g. colour reactions), indicates that a positive reaction was obtained.

(-) “negative”: Indicates that the analyte is not identified.

(ANP): Analysis not performed.



Identified substances for Test Sample 1

Code Identified Substances0709WO 6-MAM, Morphine, Codeine

1C2WN2 opiates

1M39MI codeine, morphine, 6-monoacetylmorphine

2I1J7W codeine, 6 MAM and morphine

3ESBDT CODEINE, ACETYLMORPHINE

5A0LTW morphine, 6-MAM, codeine

5D8EIT Morphine, Heroin and Codeine

6H33U3 Codeine and 6-MAM

6ZZZCD morphine,codeine, 6-monoacethylmorphine

76JL37 morphine, 6-MAM, codeine

7HEM7O Codeine

98KDM8 Morphine, codeine and monoacetly-morphine

ABBR1D Morphine,O6-monoacetylmorphine,codeine

AKQ21O morphine, codeine and 6-acetyl-morphine

ANXWGY Codeine, morphine and 6-Monoacethylmorphine

BBRB0E Morphine

BJG4OO 6-MAM, codeine, morphine

BPL9ZY morphine, 6-MAM, codeine

BVABMB 6-MAM, codeine, morphine

CUH0QQ CODEINE, MORPHINE AND MORPHINE-6-ACETYL.

CWOOM9 codeine, morphine, 6-mam

CZJD27 morphine, codeine

D7TTWV OPIÁCEOS

DONO2Y 6-MAM, codeine, morphine

ERWOWW Codeine

FNSUKR 6-monoacetilmorfina, morfina, codeina

ILS9UP Codeine, Morphine, 6-Monoacetylmorphine

J2FAYZ opiates

J6WWIX Heroin abuse

JBUJJA Codeine

JLCQ3D CODEINE

JWS3VW morphine, codeine, 6-mam

JZ6JTH Amphetamine

KHMLHA Morphine, Codeine, 6-monoacetylmorphine.

KKPG9K 6-Monoacetylmorphine, Morphine and Codeine

LFLTTZ Opiates

M8E6T6 morphine, codeine, 6-monoacetylomorphine

NDS3R3 codeine, morphine, monoacetylmorphine

OOOQSO 6-monoacetylmorphine, morphine, codeine

PSXQYE Morphine, Codeine, 6-MAM

Sample 1 Analysis



Code Identified SubstancesQHGM5Q Morphine, Codeine, 6-MAM

RFGGQG codeine, morphine, 6-monoacetylmorphine

SAV6NX 6MAM, Morphine and codeine

TTAVXV Morphine, codeine and 6-monoacetyl-morphine

UM0M1S Codeine, Morphine, 6-MAM

VHDEKU Codeine+morphine+6MAM

WIYO85 Opiates

WWSTWW morphine, codeine and 6-monoacetylmorphine

XA9AAA Morfine - Codeine - 6-MAM

XDXVS9 Codeine and 6-Monoacetylmorphine

XJZEEE Codeine, Morphine, 6-MA

XLEICI CODEINE

XTLXKX Morphine, Codeine, 6-Monoacetylmorphine

XXHQNV Morphine and 6-MAM

YCEET4 cideine,MAM, morphine



Code 6-Monoacetylmorphine (6-MAM)

Codeine Morphine (Total)

0709WO + + +-

1C2WN2 + + +morphinecodeine6-monoacetylmorphinecaffeine

1M39MI + + +sample positive for opiates

2I1J7W + + +

3ESBDT + + ANPCodeine and Acetylmorphine were detected.

5A0LTW + + +

5D8EIT + + -The sample contain: 2560 ng/mL of morphine, 1200 ng/ml of coedine. Heroin and caffeine was also detected.

6H33U3 + + ANPCodeine and 6-MAM was detected in sample BS1 but quantification analysis was not performed.

6ZZZCD + + +2013/1/BS-1 urine sample contain morphine,codine,6-monoacethylmorphine(heroine user)

76JL37 + + +Findings indicate that the person consumed heroin.

7HEM7O - + -

98KDM8 + + +The urine was found to contain morphine, codeine and monoacetyl-morphine.

ABBR1D + + +

AKQ21O + + +The presence of morphine, codeine and 6-acetyl-morphine indicates the use of heroin.

ANXWGY + + +Codeine, morphine and 6-Monoacethylmorphine detected

Statement of findings for Test Sample 1





BBRB0E ANP + +we found morphine in BS-1 as a controlled substance

BJG4OO + + +There was heroine consumption

BPL9ZY + + +We also found caffeine in BS-1.

BVABMB + + +sample positive to 6 MAM: 425.2 ng/ml (cut-off 100 ng/ml)sample positive to codeine:591.3 ng/ml (cut-off 100 ng/ml)sample positive to total morphine:1845.3 ng/ml (cut-off 100 ng/ml)

CUH0QQ + + +IN THE ROUND AS LABELED "ROUND ICE 2013/1 SAMPLE BS-1" DETECTED CODEINE, MORPHINE AND MORPHINE-6-ACETYL.

CUUFFQ + + +

CWOOM9 + + +Compatible with consum of heroin

CZJD27 ANP + +Test sample contains morphine and codeine at 2739.84 ng/mL and 1199.05 ng/mL respectively using GCMS

D7TTWV ANP ANP ANPPOSITIVO (PRESUNTIVO)

DONO2Y + + +6-MAM was detected in urine. Results indicate the previous use of heroin, a controlled narcotic (illegal).

The concentration of GHB reflect the physiological concentrations.ERWOWW - + -

Codeine was identified by GC/MS

FNSUKR + + +La coincidencia entre los tiempos de retención y fragmentogramas de una muestra biológica analizada en las mismas condiciones de un estandar indica la presencia de 6 monoacetilmorfina, morfina y codeína en esta.

FZZZZQ ANP ANP ANP

ILS9UP + + +Codeine, Morphine, 6-Monoacetylmorphine

J2FAYZ + + +we have not received standards





J6WWIX + + +Presence of 6-MAM

JBUJJA - + +free

JLCQ3D - + -The sample BS-1 contain CODEINE

JWS3VW + + +

JZ6JTH - - -

KHMLHA + + +In the urine sample analyzed, was detected and confirmed the presence of Morphine, Codeine, 6-monoacetylmorphine.

KKPG9K + + +The sample contains 6-Monoacetylmorphine, morphine and codeine.

LFLTTZ - + +Codeine, Morphine and metabolites

M8E6T6 + + +use of opiates

MDKW7J + + +

NDS3R3 + + +consumption of diacetylmorphine

OOOQSO + + +

PSXQYE + + +Sample is positive for Morphine, Codeine and 6-MAM

QHGM5Q + + +

RFGGQG + + +sample positive for opiates

SAV6NX + + +Morphine and codeine are metabolites of 6MAM. Presence of 6MAM indicates a heroin consumption.6MAM, Morphine and codeine are controlled narcotics in France





TTAVXV + + +The 6-monoacetylmorphine detection indicates heroin consumption, codeine could bepresent as heroin impurity or could come from the intake of the drug itself. Finally,morphine could come from the heroin or codeine consumption or could come from theintake of the drug itself.

UM0M1S + + +Screening by immunoassay technich : PositiveConformation by GC-MS : Positive

VHDEKU + + +Sample containing morphine+codeine+6MAM which indivates consumation of heroine

WIYO85 + - +BS1positive for: Morphine & 6MAM

WWSTWW + + +

XA9AAA + + +Codeine was consumed, Morphine indicates an opiate was consumed and 6-MAM marker of Heroin indicate this opiate was consumed.

XDXVS9 + + ANPOn analysis, the sample of 2013/1/BS-1 found to contain Codeine and 6-Monoacetylmorphine.

XJZEEE ANP ANP ANPFree morphine was measured.

XLEICI - + -Codeine was found in BS-1. Quantitation was not performed.

XTLXKX + + +Heroine abuse.

XXHQNV + + +Morphine and 6-MAM are metabolites of Heroin

YCEET4 + + +



Identification methods for Test Sample 1

Code 110 120 150 161 170 171 180 230 231 210

0709WO SI

1C2WN2 S I I

1M39MI S SI

2I1J7W S I I

3ESBDT S I I

5A0LTW S I I

5D8EIT S I

6H33U3 I

6ZZZCD S I

76JL37 S I I

7HEM7O S I I

98KDM8 S I

ABBR1D S I I

AKQ21O S I SI I

ANXWGY S I

BBRB0E S I

BJG4OO S I

BPL9ZY S SI SI

BVABMB SI

CUH0QQ S I

CUUFFQ S I

CWOOM9 S I I

CZJD27 I I S DT kits

D7TTWV S

DONO2Y S I I

ERWOWW

S I

FNSUKR S I

FZZZZQ SI

ILS9UP S I I S Kinetic Interactions of microparticles

J2FAYZ I I immunochem

J6WWIX S I I

JBUJJA S I I I

JLCQ3D SI I

Analytical Technique Codes

Legend: S ... used for Screening I ... used for Identification SI ... used for both



Code 110 120 150 161 170 171 180 230 231 210

JWS3VW S I

JZ6JTH S I I

KHMLHA S I

KKPG9K SI S Multi-Drug Screen Test Panel

LFLTTZ I S Dipromed Drulab screen

M8E6T6 S I

MDKW7J SI I

NDS3R3 S S I

OOOQSO S I

PSXQYE S S I I

QHGM5Q I I SI I

RFGGQG S SI

SAV6NX S I I

TTAVXV S I I I I

UM0M1S S I

VHDEKU SI I

WIYO85 S I

WWSTWW

S I I

XA9AAA S I S Lateral Flow Immunoassay

XDXVS9 I SI

XLEICI S I

XTLXKX S I I

XXHQNV S I

YCEET4 I



DONO2Y gamma-Hydroxybutyric acid 180

J6WWIX Methadone 180

JZ6JTH Amfetamine



110 120

Response Summary Participants: 54

Frequency of use of screening and identification techniques:

H

Summary for test sample 1The response summary of all 54 participating laboratories for the identification of BS-1, frequency of use of screening andidentification techniques and false positives and negatives:

Identification of test sample 1:

False positives for Test Sample 1

Response SummaryParticipants: 58

6-Monoacetylmorphine (6-MAM): 46

Codeine: 53

Morphine (Total): 46

Code Name Technique

230

5D8EIT Morphine-3-glucuronide 180

J2FAYZ Methadone 180

Section 110 120 150 161 170 171 180 230 231 210

Screening 36 8 4 0 0 0 9 1 1 4

62.1% 13.8% 6.9% 0.0% 0.0% 0.0% 15.5% 1.7% 1.7% 6.9%

Identification 4 0 3 11 2 2 49 5 12 2

6.9% 0.0% 5.2% 19.0% 3.4% 3.4% 84.5% 8.6% 20.7% 3.4%

# labs using this technique

36 8 7 11 2 2 49 6 12 662.1% 13.8% 12.1% 19.0% 3.4% 3.4% 84.5% 10.3% 20.7% 10.3%


False negatives for BS-1(techinque(s) used or ANP) . Within BS-1, there were: 12 false negatives for Morphine 5 false negatives for Codeine 12 false negatives for 6-Monoacetylmorphine

Z-Scores for Test Sample 1

CODE

6-Monoacetylmorphine (6-MAM)MAD: 100.0

CodeineMAD: 119.5

Morphine (Total)MAD: 440.4

Conc. * AbsDev ZScore Conc. * AbsDev ZScore Conc. * AbsDev ZScore

0709WO 500.0 52.5 0.4 1100.0 34.0 0.2 2750.0 477.5 0.7

5A0LTW 690.0 137.5 0.9 1020.0 46.0 0.3 2540.0 267.5 0.4

5D8EIT 1200.0 134.0 0.8 2560.0 287.5 0.4

76JL37 436.0 116.5 0.8 1268.0 202.0 1.1 2300.0 27.5 0.0

ABBR1D 480.0 72.5 0.5 960.0 106.0 0.6 2239.0 33.5 0.1

BJG4OO 4119.0 3566.5 24.1 21619.0 20553.0 116.1 34982.0 32709.5 50.1

BPL9ZY 626.0 73.5 0.5 1270.0 204.0 1.2 2406.7 134.2 0.2

BVABMB 425.2 127.3 0.9 591.3 474.7 2.7 1845.3 427.2 0.7

CWOOM9 420.0 132.5 0.9 990.0 76.0 0.4 1950.0 322.5 0.5

CZJD27 1199.1 133.1 0.8 2739.8 467.3 0.7

DONO2Y 556.0 3.5 0.0 1121.0 55.0 0.3 1722.0 550.5 0.8

ILS9UP 647.0 94.5 0.6 1063.0 3.0 0.0 2472.0 199.5 0.3

J2FAYZ 575.0 22.5 0.2 1311.0 245.0 1.4 1555.0 717.5 1.1

J6WWIX 510.0 42.5 0.3 930.0 136.0 0.8 1818.0 454.5 0.7

KKPG9K 549.0 3.5 0.0 1069.0 3.0 0.0 2878.0 605.5 0.9

LFLTTZ 1000.0 1272.5 2.0

M8E6T6 650.0 97.5 0.7 1545.0 479.0 2.7 2245.0 27.5 0.0

MDKW7J 590.0 37.5 0.3 1300.0 234.0 1.3 2000.0 272.5 0.4

PSXQYE 705.0 152.5 1.0 1063.0 3.0 0.0 2508.0 235.5 0.4

QHGM5Q 450.0 102.5 0.7 900.0 166.0 0.9 1980.0 292.5 0.4

SAV6NX 730.0 177.5 1.2 1321.0 255.0 1.4 3319.0 1046.5 1.6

WIYO85 578.0 25.5 0.2 1510.0 762.5 1.2

WWSTWW 500.0 52.5 0.4 1220.0 154.0 0.9 2240.0 32.5 0.0

XJZEEE 769.0 216.5 1.5 984.0 82.0 0.5 2629.0 356.5 0.5

XTLXKX 580.0 27.5 0.2 974.0 92.0 0.5 2726.0 453.5 0.7

*) Concentration: ng/ml

Z-Score has been calculated as modified Z-Score as it is a robust method and therefore relatively insensitive to outliers.Modified Z-Score = 0.6745 * AbsDev/MADAbsDev = Absolute value of the difference between a laboratory value and the median of all the laboratory values for the given drug;MAD = median absolute deviation about the median.Modified Z-scores with an absolute value of greater than 3.5 should be considered as potential outliers.Reference:Iglewicz, B. and Hoaglin, D. C.: 1993 How to Detect and Handle Outliers, American Society for Quality Control, Milwaukee, WI

2013/1-BS Copyright (c) 2013 UNODC


(14)

Substance: BS-1/6-Monoacetylmorphine (6-MAM) 100MAD =Median = 552.5

Round: 2013/1


Z-Score Report per Sample per Substance

UNODC value = 576

(15)

Substance: BS-1/Codeine 120MAD =Median = 1066

Round: 2013/1



UNODC value = 1150

(16)

Substance: BS-1/Morphine (Total) 440.4MAD =Median = 2272.5

Round: 2013/1



UNODC value = 2300

(17)


Code Identified Substances0709WO Amfetamine, Nordiazepam, Oxazepam, Temazepam

1C2WN2 amphetamines

1M39MI oxazepam, nordiazepam, temazepam and amphetamine

2I1J7W nordazepam, oxazeam, temazepam and amfetamine

3ESBDT Nordazepam

5A0LTW nordazepam, temazepam, oxazepam, amfetamine

5D8EIT Nordazepam, oxazepam, temazepam, theobromine

6H33U3 Nordazepam and Temazepam

6ZZZCD nordazepam,methamphetamine(traces)

76JL37 amfetamine, nordazepam, temazepam, oxazepam

7HEM7O Nordazepam

98KDM8 Nordiazepam and amphetmaine

ABBR1D Amphetamine,Nordazepam,Oxazepam,Temazepam

AKQ21O amphetamine, nordiazepam, temazepam and oxazepam

ANXWGY Nordazepam and temazepam

BBRB0E amphetamine

BJG4OO temazepam, nordazepam

BPL9ZY diazepam, nordazepam,oxazepam, temazepam

BVABMB amphetamine, oxazepam, nordiazepam, temazepam

CUH0QQ AMPHETAMINE, NORDIAZEPAM, OXAZEPAM AND DIAZEPAM

CWOOM9 Amfetamine, nordazepam

CZJD27 amphetamine, nordazepam, oxazepam

D7TTWV ANFETAMINAS + BENZODIACEPINAS

DONO2Y amfetamine

ERWOWW Amphetamine and Nordazepam

FNSUKR Temazepam, nordiazepam

ILS9UP Amphetamine

J2FAYZ amphetamine, benzodizepines

J6WWIX Amphetamine, benzos

JLCQ3D DESMETHYLDIAZEPAM

JWS3VW diazepam, nordazepam, temazepam, amphetamine

JZ6JTH THC

KHMLHA Temazepam, Amphetamine.

KKPG9K Amfetamine, Nordazepam and Temazepam.

LFLTTZ Amphetamine groups, benzodiazepines

M8E6T6 nordazepam, temazepam, amphetamines

MDKW7J codeine, morphine and 6acetylmorphine

NDS3R3 amphetamine, temazepam, nordazepam, oxazepam

OOOQSO amphetamine, diazepam, nordazepam, oxazepam, temazepam

PSXQYE Amfetamine, Nordazepam, Oxazepam, Temazepam

Sample 2 Analysis



Code Identified SubstancesQHGM5Q Amfetamine, Nordazepam, Oxazepam, Temazepam

RFGGQG oxazepam, nordiazepam, temazepam and amphetamine

SAV6NX Amfetamine, Nordazepam, oxazepam and Temazepam

TTAVXV Amphetamine, oxazepam, nordiazepam and temazepam.

UM0M1S Nordazepam, Amphetamine

VHDEKU Amphetamine+nordazepam+Temazepam

WIYO85 AMPHETAMINE & BENZO

WWSTWW amphetamine, nordazepam, oxazepam and temazepam

XA9AAA Amfetamine - Nordazepam

XDXVS9 Nordazepam and Temazepam

XJZEEE Amphetamine, Temazepam, Nordiazepam

XLEICI Nordazepam

XTLXKX Amphetamine, Nordazepam, Oxazepam, Temazepam

XXHQNV Nordazepamand Oxazepam

YCEET4 amfetamine



Code Amfetamine Nordazepam Oxazepam Temazepam0709WO + + + +

-

1C2WN2 + + + +amphetamineoxazepamnordiazepamtemazepamcaffeine

1M39MI + + + +sample positive for benzodiazepines and amphetamine

2I1J7W + + + +

3ESBDT - + - -Nordazepam was detected.

5A0LTW + + + +

5D8EIT - + + +The sample contain 2105.43 ng/mL of nordazepam. Oxazepam, temazepam, theobromine and caffeine was detected.

6H33U3 ANP + ANP +Nordazepam and Temazepam was detected in sample BS2 but quantification analysis was not performed.

6ZZZCD - + ANP -2013/1/BS-2 urine contain methamphetamine(traces),nordazepam(diazepam, methamphetamine user)

76JL37 + + + +Findings indicate that the person consumed amfetamine and one of or the combination of 1,4 - benzodiazepines.

7HEM7O - + - -

98KDM8 + + - -The urine was found to contain nordiazepam and amphetamine.

ABBR1D + + + +

AKQ21O + + + +The presence of amphetamine indicates the use of amphetamine. The presence of nordiazepam, temazepam and oxazepam indicates the use of diazepam.

ANXWGY ANP + ANP +Nordazepam and temazepam detected




Code Amfetamine Nordazepam Oxazepam TemazepamBBRB0E + ANP ANP ANP

we found amphetamine in BS-2 as a controlled substance

BJG4OO - + ANP +There was temazepam consumption

BPL9ZY - + + +We also found caffeine and demoxepam in BS-2.

BVABMB + + + +sample positive to amphetamine:1197.2 (cut-off 250 ng/ml)sample positive to oxazepam:213.6 (cut-off 100 ng/ml)sample positive to nordiazepam :805.3 ng/ml (cut-off 100 ng/ml)

sample positive to temazepam: no quantification performed due to lack of certified standardCUH0QQ + + + -

IN THE ROUND AS LABELED "ROUND ICE 2013/1 SAMPLE BS-2" DETECTED DIAZEPAM, OXAZEPAM, NORDIAZEPAM AND AMPHETAMINE.

CUUFFQ + + + +

CWOOM9 + + - -

CZJD27 + + + ANPTest sample contains amphetamine (1066.26 ng/mL) using GCMS and nordazepam(1652.28 ng/mL) and oxazepam (1035.11ng/mL) using LCMSMS

D7TTWV ANP ANP ANP ANPPOSITIVO (PRESUNTIVO)

DONO2Y + + + +Amfetamine was detected in urine. Results indicate the previous consumption of controlled narcotic (illegal), amfetamine or metamfetamine.The concentration of GHB reflect the physiological concentrations.

ERWOWW + + - -Amphetamine and Nordazepam were identified by GC/MS

FNSUKR ANP + - +La coincidencia entre los tiempos de retención y fragmentogramas de un material de referencia analizado en las mismas condiciones de una muestra biológica indica la presencia de temazepam y nordiazepam en esta.

FZZZZQ - ANP ANP ANP

ILS9UP + + + +Amphetamine, Nordazepam, Temazepam, Oxazepam

J2FAYZ + + + +we have not received standards



Code Amfetamine Nordazepam Oxazepam TemazepamJ6WWIX + + + +

Presence of metabolites

JBUJJA - - - ANP

JLCQ3D - + - -The sample BS-2 contain DESMETHYLDIAZEPAM

JWS3VW + + - +

JZ6JTH - ANP ANP ANP

KHMLHA + ANP - +In the urine sample analyzed, was detected and confirmed the presence of Temazepam, Amphetamine.

KKPG9K + + - +The sample contains amfetamine, nordazepam and temazepam.

LFLTTZ + - - -Amphetamin

M8E6T6 ANP + - +use of benzodiazepines and amphetamines

MDKW7J + + + +

NDS3R3 + + + +consumption of amphetamine and diazepam or medazepam

OOOQSO + + + +

PSXQYE + + + +Sample is positive for Amfetamine, Nordazepam, Oxazepam and Temazepam

QHGM5Q + + + +

RFGGQG + + + +sample positive for benzodiazepines and amphetamine

SAV6NX + + + +Amfetamine is used for recreationnal purposes. It's a controlled narcotic in France. Nordazepam, oxazepam and temazepam are benzodiazepines, used for their anxiolytic and sedativ properties and also to treat epilepsy. Are also 3 metabolites of diazepam and their presence may indicates a diazepam consumption.



Code Amfetamine Nordazepam Oxazepam TemazepamTTAVXV + + + +

The oxazepam, nordiazepam and temazepam detection indicates most likely: diazepamconsumption, nevertheless the presence of these substances could come from the intake ofthe drugs itself or come from the intake of any other benzodiazepine that producesdiazepam as a metabolite.The amphetamine detection indicates the intake of the drug itself or could come from themetabolism of other drugs such as methamphetamine.

UM0M1S + + - -Screening by immunoassay technich : PositiveConformation by GC-MS : Positive

VHDEKU + + - +Sample containing Amphetamine+Nordazepam+Temazepam, substances under control

WIYO85 + + + +BS2 positive for:amphetamine, nordazepam, oxazepam & temazepam

WWSTWW + + + +

XA9AAA + + - -Amfetamine was detected, no other drugs as methamfetamine or drugs metabolizing to amfetamine were identified, this indicate that amfetamine was consumedIn the sample was detected Nordazepam, this finding indicate that Nordazepam was consumed

XDXVS9 - + - +On analysis, the sample of 2013/1/BS-2 found to contain Nordazepam and Temazepam.

XJZEEE ANP ANP ANP ANP

XLEICI - + - -Nordazepam was found in BS-2. Quantitation was not performed.

XTLXKX + + + +1. "Speed" (amphetamine) abuse. 2. Consumption of nordazepam and temazepam is most likely. However, use of other benzodiazepine type drug (e.g. diazepam) can not be excluded.

XXHQNV ANP + + -Nordazepam and Oxazepam are common metabolites of 1-4, Benzodiazepines groups of drugs

YCEET4 + ANP ANP ANP




Code 110 120 150 161 170 171 180 230 231 210

0709WO SI

1C2WN2 S I I

1M39MI S SI

2I1J7W S I I

3ESBDT S I I

5A0LTW S I I

5D8EIT S I

6H33U3 I

6ZZZCD S I

76JL37 S I I

7HEM7O S I I

98KDM8 S I

ABBR1D S I I

AKQ21O S I SI I

ANXWGY S I

BBRB0E S I

BJG4OO S I

BPL9ZY S SI SI

BVABMB SI

CUH0QQ S I

CUUFFQ S I

CWOOM9 S I I


D7TTWV S

DONO2Y S I I

ERWOWW

S I

FNSUKR S I

FZZZZQ SI



J6WWIX S I I

JBUJJA S I I I

JLCQ3D SI I





Code 110 120 150 161 170 171 180 230 231 210

JWS3VW S I

JZ6JTH S I I

KHMLHA S I



M8E6T6 S I

MDKW7J SI I

NDS3R3 S S I

OOOQSO S I

PSXQYE S S I I

QHGM5Q I I SI I

RFGGQG S SI

SAV6NX S I I

TTAVXV S I I I I

UM0M1S S I

VHDEKU SI I

WIYO85 S I

WWSTWW

S I I


XDXVS9 I SI

XLEICI S I

XTLXKX S I I

XXHQNV S I

YCEET4 I





Section 110 120



H

Summary for test sample 2The response summary of all 54 participating laboratories for the identification of BS-2, frequency of use of screening andidentification techniques and false positives and negatives:


False positives for Test Sample 2



Amfetamine: 39

Nordazepam: 49

Oxazepam: 30

Temazepam: 37

False negatives for BS-2 (techinque(s) used or ANP) . Within BS-2, there were: 19 false negatives for Amfetamine 9 false negatives for Nordazepam 28 false negatives for Oxazepam 21 false negatives for Temazepam

Code

Name TechniqueMDKW75 Codeine, Morphine, 6-MAM in report

JWS3VW Diazepam 180

Name6ZZZCD Metamfetamine 150

BBRB0E Diazepam 150

BPL9ZY Diazepam, Demoxazepam 231

CUH0QQ Diazepam 180

DONO2Y gamma-Hydroxybutyric acid (GHB) 180

JZ6JTH 180

Section 110 120 150 161 170 171 180 230 231 210

Screening 36 8 4 0 0 0 9 1 1 4

62.1% 13.8% 6.9% 0.0% 0.0% 0.0% 15.5% 1.7% 1.7% 6.9%

Identification 4 0 3 11 2 2 49 5 12 2

6.9% 0.0% 5.2% 19.0% 3.4% 3.4% 84.5% 8.6% 20.7% 3.4%


36 8 7 11 2 2 49 6 12 662.1% 13.8% 12.1% 19.0% 3.4% 3.4% 84.5% 10.3% 20.7% 10.3%



CODEAmfetamineMAD: 138.0

NordazepamMAD: 241.9

OxazepamMAD: 48.0

Conc. * AbsDev ZScore Conc. * AbsDev ZScore Conc. * AbsDev ZScore

0709WO 1130.0 11.5 0.1 1500.0 152.1 0.4 350.0 120.0 1.7

5A0LTW 1740.0 621.5 3.0 1652.0 0.1 0.0 410.0 60.0 0.8

5D8EIT 2105.4 453.3 1.3

76JL37 1271.0 152.5 0.7 1888.0 235.9 0.7

ABBR1D 1320.0 201.5 1.0 1830.0 177.9 0.5 450.0 20.0 0.3

BJG4OO 33383.0 31730.9 88.6

BPL9ZY 1253.3 398.8 1.1 370.1 99.9 1.4

BVABMB 1197.2 78.7 0.4 805.3 846.8 2.4 213.6 256.4 3.6

CWOOM9 950.0 168.5 0.8 1240.0 412.1 1.2

CZJD27 1066.3 52.2 0.3 1652.3 0.1 0.0 1035.1 565.1 7.9

DONO2Y 1205.0 86.5 0.4 2146.0 493.9 1.4 518.0 48.0 0.7

ILS9UP 1106.0 12.5 0.1

J2FAYZ 242.0 876.5 4.3 765.0 887.1 2.5 113.0 357.0 5.0

J6WWIX 1107.0 11.5 0.1 612.0 1040.1 2.9 645.0 175.0 2.5

KKPG9K 890.0 228.5 1.1

LFLTTZ 1642.0 523.5 2.6

M8E6T6 1900.0 247.9 0.7

MDKW7J 1100.0 18.5 0.1 1600.0 52.1 0.1 420.0 50.0 0.7

PSXQYE 806.0 312.5 1.5 3500.0 1847.9 5.2 470.0 0.0 0.0

QHGM5Q 995.0 123.5 0.6 1350.0 302.1 0.8 460.0 10.0 0.1

SAV6NX 1101.0 17.5 0.1 2004.0 351.9 1.0 497.2 27.2 0.4

WIYO85 960.0 158.5 0.8 1570.0 82.1 0.2 481.0 11.0 0.2

WWSTWW 1231.0 112.5 0.6 1580.0 72.1 0.2 550.0 80.0 1.1

XJZEEE 1606.0 487.5 2.4 1888.0 235.9 0.7

XTLXKX 1027.0 91.5 0.4 1523.0 129.1 0.4 450.0 20.0 0.3





CODETemazepamMAD: 112.0

Conc. * AbsDev ZScore

0709WO 420.0 80.0 0.5

5A0LTW 1050.0 550.0 3.3

5D8EIT

76JL37

ABBR1D 460.0 40.0 0.2

BJG4OO 17160.0 16660.0 100.4

BPL9ZY 363.0 137.0 0.8

BVABMB

CWOOM9

CZJD27

DONO2Y

ILS9UP

J2FAYZ 138.0 362.0 2.2

J6WWIX 233.0 267.0 1.6

KKPG9K 360.0 140.0 0.8

LFLTTZ

M8E6T6

MDKW7J 460.0 40.0 0.2

PSXQYE 1900.0 1400.0 8.4

QHGM5Q 480.0 20.0 0.1

SAV6NX 612.0 112.0 0.7

WIYO85 517.0 17.0 0.1

WWSTWW 500.0 0.0 0.0

XJZEEE 961.0 461.0 2.8

XTLXKX 447.0 53.0 0.3



(28)

Substance: BS-2/Amfetamine 138.MAD =Median = 1118.5

Round: 2013/1



UNODC value = 1143

(29)

Substance: BS-2/Nordazepam 241.9MAD =Median = 1652.1

Round: 2013/1



UNODC value = 1727

(30)

Substance: BS-2/Oxazepam 48MAD =Median = 470

Round: 2013/1



UNODC value = 457

(31)

Substance: BS-2/Temazepam 112MAD =Median = 500

Round: 2013/1



UNODC value = 464

(32)


Code Identified Substances0709WO GHB

2I1J7W GHB

3ESBDT None

5A0LTW GHB

76JL37 GHB

ABBR1D GHB

AKQ21O GHB

BPL9ZY GHB, GBL

CUH0QQ NONE

DONO2Y GHB

J2FAYZ nordiazepam below cut-off

JLCQ3D ANY DRUGS

JZ6JTH Morphine

MDKW7J amphetamine, nodiazepam, oxazepam and temazepam

PSXQYE gamma-Hydroxybutyric acid (GHB)

SAV6NX GHB

WWSTWW GHB

XA9AAA GHB

XTLXKX gamma-Hydroxybutyric acid

Sample 3 Analysis



Code gamma-Hydroxybutyric acid (GHB)

0709WO +-

1C2WN2 ANPcaffeine

1M39MI ANP

2I1J7W +

3ESBDT ANPNegative

5A0LTW +

5D8EIT ANPThe contain caffeine.

6H33U3 ANPNo drugs detected in sample BS3.

6ZZZCD ANP

76JL37 +Findings indicate that the person consumed GHB.

7HEM7O -

98KDM8 ANP

ABBR1D +

AKQ21O +The presence of GHB indicates the use of GHB or GBL.

ANXWGY ANPNo drugs was detected

BBRB0E ANPwe did not find any controlled drug in BS-3





BJG4OO ANPnot detected any of the substances investigated

BPL9ZY +We also found caffeine in BS-3.

BVABMB ANP

CUH0QQ -IN THE ROUND AS LABELED "ROUND ICE 2013/1 SAMPLE BS-3" NOT DETECTED METABOLITES OF COCAINE, CANNABINOIDS, BENZODIAZEPINES, AMPHETAMINES, PHENOTHIAZINES AND TRICYCLIC ANTIDEPRESSANTS.

CUUFFQ ANP

CWOOM9 -

CZJD27 ANPNo drugs found based on test performed

D7TTWV ANPNO SE DETECTÓ

DONO2Y +The concentration of GHB (>10 mg/L) reflect a suspicion case of recreative use or drug-facilitated crime.

ERWOWW -

FNSUKR ANPEn inmunoensayo una concentración menor al punto de corte indica que el sistema analítico no detectó la presencia de cocaína, cannabinoides , anfetaminas, barbitúricos ni benzodiacepinas.

FZZZZQ ANP

ILS9UP ANP

J2FAYZ -we have not received standards

J6WWIX ANP

JBUJJA ANP




JLCQ3D ANPThe sample BS-3 no contain any drugs

JWS3VW ANP

JZ6JTH ANP

KHMLHA ANP

KKPG9K ANP

LFLTTZ ANP

M8E6T6 ANP

MDKW7J ANP

NDS3R3 ANP

OOOQSO ANP

PSXQYE +Sample is positive for Gamma-Hydroxybutyric acid (GHB)

QHGM5Q -

RFGGQG ANP

SAV6NX +GHB is a controlled substance since 1999 in France. GHB has been used in a medical setting as a general anesthesic. GHB is a central nervous system used as an intoxicant

TTAVXV ANP

UM0M1S -

VHDEKU ANP




WIYO85 -BS3 was negative for supplied standards

WWSTWW +

XA9AAA +GHB was detected, cuantitication was not performed, but the sample concentration was greater than a urine sample containing 10000 ng/ml

XDXVS9 ANPOn analysis, no drugs found in the sample of 2013/1/BS-3.

XJZEEE ANP

XLEICI ANP

XTLXKX +Abuse of GHB salt or GBL or 1,4-butanediol, if there is no succinic semialdehyde dehydrogenase deficiency (SSADH).

XXHQNV ANPNone Detected

YCEET4 ANP




Code 110 120 150 161 170 171 180 230 231 210

0709WO SI

1C2WN2 S I I

1M39MI S SI

2I1J7W S I I

3ESBDT S I I

5A0LTW S I I

5D8EIT S I

6H33U3 I

6ZZZCD S I

76JL37 S I I

7HEM7O S I I

98KDM8 S I

ABBR1D S I I

AKQ21O S I SI I

ANXWGY S I

BBRB0E S I

BJG4OO S I

BPL9ZY S SI SI

BVABMB SI

CUH0QQ S I

CUUFFQ S I

CWOOM9 S I I


D7TTWV S

DONO2Y S I I

ERWOWW

S I

FNSUKR S I

FZZZZQ SI



J6WWIX S I I

JBUJJA S I I I

JLCQ3D SI I





Code 110 120 150 161 170 171 180 230 231 210

JWS3VW S I

JZ6JTH S I I

KHMLHA S I



M8E6T6 S I

MDKW7J SI I

NDS3R3 S S I

OOOQSO S I

PSXQYE S S I I

QHGM5Q I I SI I

RFGGQG S SI

SAV6NX S I I

TTAVXV S I I I I

UM0M1S S I

VHDEKU SI I

WIYO85 S I

WWSTWW

S I I


XDXVS9 I SI

XLEICI S I

XTLXKX S I I

XXHQNV S I

YCEET4 I





Section


R


Summary for The response summary of all 54 participating laboratories for the identification of BS-3, frequency of use of screening andidentification techniques and false positives and negatives:


False positives for Test Sample



gamma-Hydroxybutyric acid (GHB): 13

False negatives for BS-3 . Within BS-3, there were: 8 false negatives for GHB by participants using analytical techniques

CUHOQQ (180), QHGM5Q (171/180), UM0MIS (180), WIYO85 (231), ERWOWW (180) CWOOM9 (180), 7HEM7O (171/180), J2FAYZ (180) 37 false negatives by particpants who did not carry out analyses for GHB

Code

Name TechniqueMDKW75 Amfetamine, Nordazepam, in report

MDKW75 Oxazepam, Temazepam in report

NameJZ6JTH Morphine 230

J2FAYZ Nordazepam 180

Section 110 120 150 161 170 171 180 230 231 210

Screening 36 8 4 0 0 0 9 1 1 4

62.1% 13.8% 6.9% 0.0% 0.0% 0.0% 15.5% 1.7% 1.7% 6.9%

Identification 4 0 3 11 2 2 49 5 12 2

6.9% 0.0% 5.2% 19.0% 3.4% 3.4% 84.5% 8.6% 20.7% 3.4%


36 8 7 11 2 2 49 6 12 662.1% 13.8% 12.1% 19.0% 3.4% 3.4% 84.5% 10.3% 20.7% 10.3%



CODE

gamma-Hydroxybutyric acid (GHB)MAD: 1114.5

Conc. * AbsDev ZScore

0709WO 15500.0 575.0 0.3

5A0LTW 14350.0 575.0 0.3

ABBR1D 16500.0 1575.0 1.0

BPL9ZY 14300.0 625.0 0.4

DONO2Y 17.8 14907.2 9.0

PSXQYE 140100.0 125175.075.8

SAV6NX 14283.0 642.0 0.4

WWSTWW 15579.0 654.0 0.4

XTLXKX 10543.0 4382.0 2.7





(41)

Substance: BS-3/gamma-Hydroxybutyric acid (GHB) 1114.5MAD =Median = 14925

Round: 2013/1



UNODC value = 14427

(42)


Sample 4 Analysis



Code


Identified Substances76JL37 ephedrine

1M39MI ephedrine

BPL9ZY ephedrine

KKPG9K ephedrine

MDKW7J ephedrine

NDS3R3 ephedrine

WWSTWW ephedrine

OOOQSO ephedrine

RFGGQG ephedrine

UM0M1S ephedrine

5D8EIT ephedrine

Code [blank sample]0709WO -

1C2WN2 caffeine

1M39MI sample positive for ephedrine

2I1J7W

3ESBDT Negative

5A0LTW

5D8EIT The sample contain pseudoephedrine / ephedrine and caffeine.

6H33U3 No drugs detected in sample BS4.

6ZZZCD

76JL37 Findings indicate that the person consumed ephedrine or pseudoephedrine.

7HEM7O

98KDM8

ABBR1D

AKQ21O No drugs found.

ANXWGY No drugs was detected

BBRB0E we did not find any controlled drug in BS-4

BJG4OO not detected any of the substances investigated




Code [blank sample]BPL9ZY We also found caffeine and ephedrine in BS-4.

BVABMB

CUH0QQ IN THE ROUND AS LABELED "ROUND ICE 2013/1 SAMPLE BS-4" NOT DETECTED METABOLITES OF COCAINE, CANNABINOIDS, BENZODIAZEPINES, AMPHETAMINES, PHENOTHIAZINES AND TRICYCLIC ANTIDEPRESSANTS.

CUUFFQ

CWOOM9

CZJD27 No drugs found based on test performed

D7TTWV NO SE DETECTÓ

DONO2Y The concentration of GHB reflect the physiological concentrations.

ERWOWW

FNSUKR En inmunoensayo una concentración menor al punto de corte indica que el sistema analítico no detectó la presencia de cocaína, cannabinoides , anfetaminas, barbitúricos ni benzodiacepinas.

FZZZZQ

ILS9UP

J2FAYZ we have not received standards

J6WWIX

JBUJJA

JLCQ3D The sample BS-4 no contain any drugs

JWS3VW



Code [blank sample]JZ6JTH

KHMLHA

KKPG9K The sample contains ephedrine.

LFLTTZ

M8E6T6

MDKW7J sample 5 contains ephedrine (GC-MS)

NDS3R3 ephedrine was found in the sample

OOOQSO ephedrine was identified in sample 2013/1/BS-4 by LC/MS and its presence was confirmed by LC/MS/MS

PSXQYE Sample contains no substance from the ICE menu

QHGM5Q

RFGGQG sample positive for ephedrine

SAV6NX

TTAVXV

UM0M1S Screening and conformation by GC-MS : Positive

VHDEKU

WIYO85 BS4 was negative for supplied standards

WWSTWW Ephedrine is found in BS-4, but ephedrine is not the controlled drug.



Code [blank sample]XA9AAA

XDXVS9 On analysis, no drugs found in the sample of 2013/1/BS-4.

XJZEEE

XLEICI Phenmetrazine was found in BS-4.

XTLXKX

XXHQNV None Detected

YCEET4




Code 110 120 150 161 170 171 180 230 231 210

0709WO SI

1C2WN2 S I I

1M39MI S SI

2I1J7W S I I

3ESBDT S I I

5A0LTW S I I

5D8EIT S I

6H33U3 I

6ZZZCD S I

76JL37 S I I

7HEM7O S I I

98KDM8 S I

ABBR1D S I I

AKQ21O S I SI I

ANXWGY S I

BBRB0E S I

BJG4OO S I

BPL9ZY S SI SI

BVABMB SI

CUH0QQ S I

CUUFFQ S I

CWOOM9 S I I


D7TTWV S

DONO2Y S I I

ERWOWW

S I

FNSUKR S I

FZZZZQ SI



J6WWIX S I I

JBUJJA S I I I

JLCQ3D SI I





Code 110 120 150 161 170 171 180 230 231 210

JWS3VW S I

JZ6JTH S I I

KHMLHA S I



M8E6T6 S I

MDKW7J SI I

NDS3R3 S S I

OOOQSO S I

PSXQYE S S I I

QHGM5Q I I SI I

RFGGQG S SI

SAV6NX S I I

TTAVXV S I I I I

UM0M1S S I

VHDEKU SI I

WIYO85 S I

WWSTWW

S I I


XDXVS9 I SI

XLEICI S I

XTLXKX S I I

XXHQNV S I

YCEET4 I





False positives for Test Sample 4Code

R


Summary for The response summary of all 54 participating laboratories for the identification of BS-4, frequency of use of screening andidentification techniques and false positives and negatives:




Code

CodeCode

Name TechniqueJ2FAYZ Nordazepam 180

Name

Name

DONO2Y Gamma-Hydroxybutyric acid (GHB) 180

JZ6JTH Methylecgonine, Benzoylecgonine 230

XLEICI Phenmetrazine 180

YCEET4 Metamfetamine 180

Section 110 120 150 161 170 171 180 230 231 210

Screening 36 8 4 0 0 0 9 1 1 4

62.1% 13.8% 6.9% 0.0% 0.0% 0.0% 15.5% 1.7% 1.7% 6.9%

Identification 4 0 3 11 2 2 49 5 12 2

6.9% 0.0% 5.2% 19.0% 3.4% 3.4% 84.5% 8.6% 20.7% 3.4%


36 8 7 11 2 2 49 6 12 662.1% 13.8% 12.1% 19.0% 3.4% 3.4% 84.5% 10.3% 20.7% 10.3%


Identified Substances76JL37 ephedrine

1M39MI ephedrine

BPL9ZY ephedrine

KKPG9K ephedrine

MDKW7J ephedrine

NDS3R3 ephedrine

WWSTWW ephedrine

OOOQSO ephedrine

RFGGQG ephedrine

UM0M1S ephedrine

5D8EIT ephedrine

(50)

The Laboratory and Scientific SectionUNODC, International CentreWagramer Strasse 5, P.O. Box 500A-1400, Vienna, AUSTRIAEmail: [email protected]



(51)

Documents

INTERNATIONAL QUALITY ASSURANCE PROGRAMME (IQAP) … · 2013. 10. 9. · CWOOM9 codeine, morphine, 6-mam CZJD27 morphine, codeine D7TTWV OPIÁCEOS DONO2Y 6-MAM, codeine, morphine