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IPBS YEAR 2
Interdisciplinary Biomedical Sciences
COURSE SYLLABUS
2013
COURSE DESCRIPTION It is a challenging task to analyze and evaluate each human body function as an interdependent
network. This course introduces students to the topics in structural biology, cell biology,
neuroscience, immunology, imaging technology, regenerative medicine, and drug development.
This course consists of 6 modules for which students will receive 6 credit hours (1 credit each)
and 6 letter grades. All modules are based on guest lectures (see tentative schedule of each
module syllabus). Each 80 minutes lecture consists of background (20 mins), current research
findings and trends (30 mins), future perspectives (10 mins), relation to other biological systems
(10 mins), followed by a brief discussion. Then, 10 minutes will be allocated to work on an
assignment.
The course (6 credit hours) is required for completing the Interdisciplinary Program for
Biomedical Sciences. Students are expected to attend all lectures and submit a short summary for
each lecture.
PREREQUISITE: a completion of IPBS Basic Medical Sciences and Clinical Sciences. The course
assumes the basic knowledge of cell biology and human anatomy.
ASSIGNMENT AND GRADING
For each module (1 credit hour), you will be given a letter grade. To earn the letter grade, a short
summary (200-300 words) for each lecture must be submitted.
Unless otherwise indicated, all work you do for this class will be written in English using a
computer word processor program. Use Times New Roman, font size 12. Please include a left-
cornered header as follows: Interdisciplinary Biomedical Sciences
Date of class
Professor’s full name
Student affiliation (School, Department)
Student number
Student name
Please bring a hard copy of your summary to the IPBS administrative office, by the deadline
listed in each module syllabus. You are required to check your email at least once per day, so that
you stay on top of changes to assignments and due dates. For each short summary, up to 100
points will be given based on the accuracy and depth of understanding.
2
You are allowed 2 absences per module (no explanations needed). For each absence you will
receive zero point on the short summary. 8 highest summary scores of 10 will be counted
towards your letter grade, and 2 summary score will be dropped.
Assignment Point Value
8 lecture short summaries @ 100 points each 800
Total Possible Points 800
The grade will be assigned on the following average score range:
S ≥ 90%
A 80-89%
B 70-79%
C 60-69%
F <60%
You MUST earn a grade of C or better to pass this course!
CLASS RULES OF CONDUCT
In order to create a productive learning and teaching environment for every individual in this
course, we will adhere to the following policies:
Students who miss class for any reason are responsible for making sure they are up-to-
date with all materials and ready to participate in class.
All summary assignments must be turned in on the specified due date (see tentative
schedule of each module). Extensions may be granted only at the instructor’s discretion.
Use of mobiles is not allowed. Failure to abide by this policy will result in grade
deductions and removal from class.
The instructor may adjust the syllabus if changes are needed in order to successfully
achieve course outcomes.
Disrespectful comments and/or disruptive behavior will not be tolerated.
STATEMENT ON ACADEMIC HONESTY AND PLAGIARISM The academic community requires ethical behavior from all of its participants. Cheating and
plagiarism will not be tolerated. Plagiarism is taking someone else’s ideas, expressions, or
productions and passing them off as your own. When building your thinking on the ideas of
others, you must credit others with their contributions and to clearly indicate the boundaries of
our own thinking.
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Interdisciplinary Biomedical Sciences
Module I
Instructor:
Drs. Masayuki Miyasaka and Masaaki Murakami
Office: Miyasaka: IPBS Administration Office, 2nd Floor, Basic Research Building, Faculty of Medicine Murakami: 8th Floor, Basic Research Building, Faculty of Medicine
Office Hours: MT 3:50-5pm, or by appointment
Phone: Miyasaka: 06-6879-2630 or -2632 Murakami: 06-6879-3881
Email: [email protected] [email protected]
MODULE I : Diseases from immune system failure Through lectures on how dysregulation of the immune system causes a variety of diseases, this
module focuses on the physiological and pathological aspects of the immune system. The aim of
this module is to enhance student's knowledge of and critical thinking about the immune system
from the basics to the advanced level, particularly in relation to human diseases.
LEARNING OUTCOMES
Upon completion of this module, students should be able to:
explain the basic components and architecture of the immune system.
explain the mechanisms of homeostasis and function of the immune system.
explain disorders mediated directly and/or indirectly by the immune system
TENTATIVE SCHEDULE
Note that the schedule is subject to change.
CLASS
NUMBER
DATE
TIME
TOPICS LECTURER
Drs.
ASSIGNMENT
DUE FOR
1 4/12 16:00-
17:30
Introduction to immunology
Masayuki
Miyasaka
2 4/19 16:00-
17:30
Adaptive immune responses
Hitoshi
Kikutani
CLASS 1
3 4/26
16:00-
17:30
Pathogen recognition and innate
immunity
Shizuo
Akira
CLASS 2
4 5/10
16:00-
17:30
Compendium of immune regulation
Shimon
Sakaguchi
CLASS 3
4
5 5/17
16:00-
17:30
How dendritic cells coordinate
immune responses?
Tsuneyasu Kaisho CLASS 4
6 5/24
16:00-
17:30
Mucosal immunology
Kiyoshi
Takeda
CLASS 5
7 5/31
16:00-
17:30
Allergic immune responses
Hajime
Karasuyama
CLASS 6
8 6/7
16:00-
17:30
Immunopathogenesis of periodontal
diseases
Satoru
Toyosawa
CLASS 7
9 6/14
16:00-
17:30
Cytokine biology in cardiovascular
diseases
Yasushi
Fujio
CLASS 8
10 6/21
16:00-
17:30
Immune regulation by
microorganisms
Hisashi
Arase
CLASS 9
6/28 CLASS 10
5
Interdisciplinary Biomedical Sciences
Module II
Instructor:
Dr. Atsushi Nakagawa
Office: Structural Analysis Research Building 2F, Institute for Protein Research
Office Hours: MT 3:50-5pm, or by appointment
Phone: Ext 4313
Email: [email protected]
MODULE II: Drug development and solutions
By introducing a range of topics from structural biology to vaccine science, this module focuses
on the bridge between basic science and applications for drug development including clinical
trials. The aim of this module is to enhance student's knowledge of and critical thinking about
the development of drugs based on basic biological science and translational medicine.
LEARNING OUTCOMES
Upon completion of this module, students should be able to:
explain the basics of protein sciences based on structures of biological
macromolecules.
explain the strategies for development of biological drugs, including chemical
compounds, nucleic acids and vaccines.
TENTATIVE SCHEDULE
Note that the schedule is subject to change.
CLASS
NUMBER
DATE
TIME
TOPICS LECTURER
Drs.
ASSIGNMENT
DUE FOR
1 4/12 17:40-
19:10
Essentials of protein science Junichi
Takagi
2 4/19 17:40-
19:10
Fundamentals of structural
biology
Atsushi
Nakagawa
CLASS 1
3 4/26
17:40-
19:10
Development of new protein
crystallization techniques and their
application for drug design
Tsuyoshi
Inoue
CLASS 2
4 5/10
17:40-
19:10
Strategies for structural
bioinformatics
Daron M.
Standley
CLASS 3
5 5/17
17:40-
19:10
Chemical libraries for drug
discovery
Tadayuki
Uno
CLASS 4
6
6 5/24
17:40-
19:10
Pharmacology of biological drugs Hiroyuki
Nakayama
CLASS 5
7 5/31
17:40-
19:10
Proteomics-based target discovery
and biodrug development
Shin-ichi
Tsunoda
CLASS 6
8 6/7
17:40-
19:10
Drug development—from research
to clinical development—
Tsuneaki
Sakata
CLASS 7
9 6/14
17:40-
19:10
Principles and examples of nucleic
acid therapeutics
Satoshi
Obika
CLASS 8
10 6/21
17:40-
19:10
From bench to clinic: vaccine
science and clinical trials
Ken
Ishii
CLASS 9
6/28 CLASS 10
7
Interdisciplinary Biomedical Sciences
Module III
Instructor:
Drs. Ken Ishii and Masaaki Murakami
Office: Ishii: 6th Floor, iFReC Building,
Murakami: 8th Floor, Biomedical Research Building (E82-26), Faculty of Medicine
Office Hours: MT 3:50-5pm, or by appointment
Phone: Ishii: 06-6879-4948 or 072-641-8043 Murakami: 06-6879-3881
Email: [email protected] [email protected]
MODULE III: Development of New Drugs for Various Diseases Through a focus on topics in autoimmune diseases, bone-related diseases, chronic inflammation,
cancer, this module emphasizes the molecular mechanism of the cause and progression of
diseases to identify molecular targets of new drugs, from the perspective of both academia and
the pharmaceutical industry. The aim of this module is to enhance student's knowledge of and
critical thinking about the strategies of drug development for human diseases from basic to
application level.
LEARNING OUTCOMES
Upon completion of this module, students should be able to:
explain how to investigate the molecular mechanism of disease development.
explain how to identify molecular targets of new drugs for various diseases.
explain how to establish the strategy for drug development.
TENTATIVE SCHEDULE
Note that the schedule is subject to change.
CLASS
NUMBER
DATE
TIME
TOPICS LECTURER
Drs.
ASSIGNMENT
DUE FOR
1 6/28 16:00-
17:30
IL-6: Pathogenesis and treatment
of autoimmune inflammatory
diseases
Tadamitsu
Kishimoto
2 6/28 17:40-
19:10
The development of anti-IL-6
receptor antibody
Kunihiro
Hattori
3 7/5
16:00-
17:30
Osteoimmunology Hiroshi
Takayanagi
CLASS 1 and 2
4 7/5
17:40-
19:10
Structural basis for chronic
inflammation and cancer;
Osamu
Nureki
8
structure-based drug design
5 7/12
16:00-
17:30
Discovery of tumor vaccine Haruo
Sugiyama
CLASS 3 and 4
6 7/12
17:40-
19:10
Molecular design of cytokines Yasuo
Tsutsumi
7 7/19
16:00-
17:30
Drug discovery in a company Yoshinori
Ikeura
CLASS 5 and 6
8 7/19
17:40-
19:10
iPS and drug development Hiroyuki
Mizuguchi
9 7/26
16:00-
17:30
Chronic inflammation, roles of
cytokines and neural activation
Masaaki
Murakami
CLASS 7 and 8
10 7/26
17:40-
19:10
Molecular targets of tumor Eisuke
Mekada
8/2 CLASS 9 and 10
9
Interdisciplinary Biomedical Sciences
Module IV
Instructor:
Dr. Akihiro Harada
Office: E51-05, 5th Floor, Bioscience Research Building, Faculty of Medicine
Office Hours: MT 3:50-5pm, or by appointment
Phone: Ext 3210 or 3211
Email: [email protected]
MODULE IV: Contrast and cooperation between the immune system and the nervous system Through a focus on “crosstalks” of the immune and nervous systems, this module emphasizes
the physiological functions and disorders specifically caused by the interactions of the two
systems. The aim of this module is to enhance student's knowledge of and critical thinking about
the effects one system has on others in biological function.
LEARNING OUTCOMES
Upon completion of this module, students should be able to:
explain the basic components and architecture of the nervous system.
explain the mechanisms of homeostasis and function of the nervous system in
comparison with those of the immune system.
explain disorders of the nervous system and their pathophysiology as well as the crosstalk
with the immune system.
TENTATIVE SCHEDULE
Note that the schedule is subject to change.
CLASS
NUMBER
DATE
TIME
TOPICS LECTURER
Drs.
ASSIGNMENT
DUE FOR
1 10/4 16:00-
17:30
Basic concepts of
the nervous system
Shoichi
Shimada
2 10/4 17:40-
19:10
Cell polarity of neurons and
immune cells
Akihiro
Harada
3 10/11
16:00-
17:30
Nervous system as excitable cellular
network
Yasushi
Okamura
CLASS 1 and 2
4 10/11
17:40-
19:10
Membrane trafficking and
autophagy
Tamotsu
Yoshimori
5 10/18
16:00-
17:30
Semaphorins: Common principles
between axonal pathfinding and
immune cell migration
Atsushi
Kumanogou
CLASS 3 and 4
10
6 10/18
17:40-
19:10
Coupling between immune system
and nervous system during the CNS
injury
Toshihide
Yamashita
7 10/25
16:00-
17:30
Analysis and drug development for
mental disorders using animal
models
Kazuhiro
Takuma
CLASS 5 and 6
8 10/25
17:40-
19:10
Parkinson’s disease caused by
disruption of surrounding
environment of neurons
Tatsusada
Okuno
9 11/8
16:00-
17:30
Basic drug discovery research for
psychiatric disorders
Hitoshi
Hashimoto
CLASS 7 and 8
10 11/8
17:40-
19:10
miRNA: Key players in
neurodegenerative disease
Yukio
Kawahara
11/15 CLASS 9 and 10
11
Interdisciplinary Biomedical Sciences
Module V
Instructor:
Dr. Shinya Murakami
Office: C-316, 3rd Floor, Faculty of Dentistry
Office Hours: by appointment
Phone: Ext 2930 or 2932
Email: [email protected]
MODULE V: Stem cells and regenerative medicine
This module emphasizes the challenges and advances in stem cell research, development of
biomaterials, and regenerative therapies. The module aims to have the students appreciate and address
the challenges that arise in bench-to-clinic translational research.
LEARNING OUTCOMES
Upon completion of this module, students should be able to:
explain the concept of regenerative medicine and tissue engineering.
explain the characteristic and function of stem cells.
explain the cutting-edge engineering related to regenerative medicine.
explain the up-to-date regenerative therapy
TENTATIVE SCHEDULE
Note that the schedule is subject to change.
CLASS
NUMBER
DATE
TIME
TOPICS LECTURER
Drs.
ASSIGNMENT
DUE FOR
1 11/15 16:00-
17:30
Stem cells in regenerative
medicine
Toru
Nakano
2 11/22 16:00-
17:30
Biomedical optics
in regenerative medicine
Kunio
Awazu
CLASS 1
3 11/29
16:00-
17:30
Periodontal tissue engineering
Shinya
Murakami
CLASS 2
4 12/6
16:00-
17:30
Role of bone marrow
mesenchymal stem/progenitor
cells integration process of tissue
injury
Katsuto
Tamai
CLASS 3
5 12/13
16:00-
17:30
Stem cell-based therapy in
cartilage repair
Hideki
Yoshikawa
CLASS 4
6 12/20
16:00-
17:30
Fabrication of 3D-vascularized
human tissue models
Mitsuru
Akashi
CLASS 5
12
7 1/10
16:00-
17:30
Development of B cells and their
functions
Tomohiro
Kurosaki
CLASS 6
8 1/24
16:00-
17:30
Regenerative medicine for cornea
using tissue stem and iPS cells
Koji
Nishida
CLASS 7
9 1/31
16:00-
17:30
Bio-functional materials for
dental caries treatment
Satoshi
Imazato
CLASS 8
10 2/7
16:00-
17:30
Heart failure and surgical
treatment
Yoshiki
Sawa CLASS 9
2/14 CLASS 10
13
Interdisciplinary Biomedical Sciences
Module VI
Instructor:
Dr. Masaru Ishii
Office: Room 811, Integrated Life Science Building, Immunology Frontier Research Center
Office Hours: MT 3:50-5pm, or by appointment
Phone: Ext 4267 or 4268
Email: [email protected]
MODULE VI: Advanced imaging techniques opening windows on integrated biomedical
systems This module focuses on the principle and application of various imaging techniques, such as
advanced optical microscopies, fluorescent probes, and radio and magnetic medical imaging, all
of which have developed rapidly in recent years and continue to advance in biomedical sciences.
The aim of this module is to provide students with the latest information about advanced imaging
techniques and to enhance their understanding on how these technologies contribute to opening
new windows on integrated biomedical systems.
LEARNING OUTCOMES
Upon completion of this module, students should be able to:
explain the basic principles and applications of advanced imaging techniques.
explain the mechanisms of various imaging techniques: advanced optical microscopies,
fluorescent probes, and radio and magnetic medical imaging.
explain how these new imaging technologies contribute to the advancement of many
research fields.
TENTATIVE SCHEDULE
Note that the schedule is subject to change.
CLASS
NUMBER
DATE
TIME
TOPICS LECTURER
Drs.
ASSIGNMENT
DUE FOR
1 11/15 17:40-
19:10
Principle of optical imaging and
its application to medical sciences
Masaru
Ishii
2 11/22 17:40-
19:10
Development of chemical
fluorescent probes
Kazuya
Kikuchi
CLASS 1
3 11/29
17:40-
19:10
Principle and application of two-
photon microscopy
Kazuhiro
Suzuki
CLASS 2
4 12/6
17:40-
19:10
Imaging of cellular functions by a
variety of fluorescent proteins
Atsushi
Miyawaki
CLASS 3
14
5 12/13
17:40-
19:10
Single molecular imaging: from
basis to application
Masahiro
Ueda
CLASS 4
6 12/20
17:40-
19:10
FRET biosensors for monitoring cell
signaling
Michiyuki
Matsuda
CLASS 5
7 1/10
17:40-
19:10
Live imaging of cellular membrane
potential
Hidekazu
Tsutsui
CLASS 6
8 1/24
17:40-
19:10
Principle and application of raman
microscopy
Nicholas
Smith
CLASS 7
9 1/31
17:40-
19:10
PET imaging: from basic to clinic
medicine
Jun
Hatazawa
CLASS 8
10 2/7
17:40-
19:10
Functional imaging of human brain Yoshichika
Yoshioka
CLASS 9
2/14 CLASS 10
