Upload
others
View
6
Download
0
Embed Size (px)
Citation preview
1
Institut Pasteur: health research and
intervention world-wide
Paul Brey
Japan Science and Technology Forum
5 October 2007
2
Institut Pasteur ’s creation
1887: Established by international fund raising (Russia, Brazil, Japan, France) following L. Pasteur’s Rabies vaccine success
« Our institute will be both a health center for treating rabies, a research center for infectious diseases and a learning center »
Louis Pasteur
3
Institut Pasteur and Japan : a long lasting relationship
• In 1886, when Pasteur raised funds to create the Institute, the personnel from a company from Yokohama participated
• The first Japanese student in the microbiology course was Dr Yabe, in 1897
• In 1922, for centennial of Pasteur’s birth, Japan donated 2 magnificent vases. They now are in the crypt, where Pasteur is buried.
•In 2005, the creation of the
Association Pasteur Japon
To help promote Institut Pasteur in Japan
Silk worm
4
Institut Pasteur
The founding vision of Institut Pasteur is to improve human health and
welfare through scientific discovery.
Challenge Today: is to translate this vision into twenty first century science and
technology within a complex global framework confronted with environmental change,
emerging infectious disease and non-infectious diseases. Aim: is to is to continue to
improve human health and welfare through scientific discovery by having a better
understanding of the underlying mechanisms of environmental change on pathogens and
their reservoirs as related to their mode of transmission, persistence and adaptation to
humans. To integrate the most cutting edge technologies along with traditional natural history
studies on pathogens, as well as to better understand the mechanisms leading to cancer and
neurological diseases.
5
Institut Pasteur in 2007
• Research
Study of infectious diseases, immune, genetic and neurological diseases for both prevention and cure.
• Public health
Reference Centers, WHO Collaborating Centers, Outpatient Medical center
• Education and training
1,100 students and trainees from 63 Countries
• International Network
30 Institutes on 5 continents
6
Institut Pasteur in 2007
A PRIVATE FOUNDATION
Annual budget (2006): 217 M €
Public Funding Donations & Legacies
Business Development : fees, royalties, expert appraisals
35 %
32% 33 %
7
Biomedical Research
and Public Health
Institut Pasteur: Research
130 laboratories
20 cutting-edge core facilitiesGenomics and Proteomics, Microarrays,
Molecular Cryo-microscopy, TEM, Dynamic Imaging, etc.
Increasing efforts on neglected and emerging diseases.
New labs and projects: Viruses (Avian Flu, Chik, …), Malaria,
Leishmania, Trypanosoma, Buruli ulcer
More than half of research is devoted to infectious diseases
9
Institut Pasteur: biomedical research
Global Health and infectious diseases
Viral diseases AIDS, Flu, dengue, rabies, hepatitis, poliomyelitis, yellow fever, SARS, haemorrhagic fevers,...
Bacterial diseases Tuberculosis, enteric diseases, plague, whooping cough, meningitis, anthrax, resistance to antibiotics,...
Parasitic diseases Malaria, leishmaniasis, amibiasis, Chagas disease, sleeping sickness...
Fungal diseases Cryptococcosis, candidiasis, aspergillosis,...
10
Institut Pasteur: biomedical research
Cancers, genetic diseasesNeuroscience and Neurodegenerative disease:
autism, deafness, Alzheimer’sDevelopment of heart muscle Genomics and post- genomics etc...
Institut Pasteur
VaccinesDiagnostic testsDrugsEnvironment
Incubator for start-up companies -several successful IPOs
Technology transfer
12
Public Health
Services
13
National Reference and WHO Collaborating Centers
20 Reference Centers and 8 WHO Collaborating Centersmonitor epidemics; provide technical advice at the
national and international level.For example : WHO reference center for Influenza and Rabies…
CIBU : emergency intervention unit for unknown pathogens on call 24 hours, 7 days/week, 365 days/yearFor example : SARS outbreak in China and Vietnam
14
The Medical Center
a Center for international
vaccination and travel medicine
an outpatient clinic, including
tropical medicine, dermatology,
parasitology, mycology and
allergic reactions
15
International
collaborations
16
• To strengthen the scientific relations with the other international organizations• To develop projects in partnership with other foundations or international actors:
World Health Organization (WHO)GAVI (Global Alliance for Vaccines and Immunization)Bill & Melinda Gates FoundationDNDi (Drugs for Neglected Diseases initiative)Bellagio ForumWellcome Trust - Oxford Tropical Medicine UnitU.S. Department of Health and Human Services
• To promote the development of regional poles : Asia, Europe, Africa, Middle-East, Latin America
The International Collaborations
17
Scientific collaborations Japan-Institut Pasteur in 2007
1. Collaborations with RIKEN
• Center for Developmental Biology, Kobe
• Research Center for Allergy & Immunology (RCAI), Yokohama
• RIKEN Tsukuba
• Research Institute for Microbial diseases (BIKEN), Osaka
• Brain Science Institute (BSI), Wako
2. Osaka University
3. Tokyo University (IMSUT)
18
Institut Pasteur International
Network
19
Origin of the International Institut Pasteur Network
Three years after the establishment of Institut Pasteur in Paris, Louis Pasteur decided to establish Institut Pasteur outside of metropolitan France sending his most talented young scientists to vaccinate populations against rabies and smallpox and to study infectious diseases
“The future belongs to those who help suffering humanity”
Louis Pasteur
20
Le Réseau International des Instituts Pasteur
In 1891, Albert Calmette founded the first Institut Pasteur outside of metropolitan France in Saigon
Today the network includes 30 institutes spanning five continents.
21
The International network of Pasteur Institutes
30 Institutes
Institut Pasteur Laos 2009
22
Institut Pasteur International Network
• Public Health• Research• Teaching & Training• Services • Vaccine Production• Technology transfer
Missions
To improve research capacityTo improve the public health in the countries where these institutes are located
QuickTime™ and aTIFF (Uncompressed) decompressor
are needed to see this picture.
23
A few examples of activities and programs addressing global health challenges
• Avian flu diagnosis and surveillance (Cambodia, Laos,
Vietnam and China)
• Development of rapid diagnosis “dip-sticks” for plague,
cholera, meningitis (IPs in Africa)
• Distribution of bed nets and malaria surveillance
• Remote Sensing Surveillance studies to help predict
outbreaks of Vector borne and Avian borne diseases
• Food safety and Environmental hygiene
Health and Sustainable development
Institut Pasteur
Network in ASIA
25
Instituts Pasteur in Asia
• Korea• Shanghai• Hong-Kong• Vietnam• Cambodia
• Laos
26
Institut Pasteur of Korea
Created in 2003
Staff : up to 250 people
RESEARCH :
• Cancer, hepatitis, inflammation
• Therapeutics targets (malaria, AI)
• Enabling technology development
Synergies between:
•IP Paris: competence in Biological research & Therapy development and •IP Korea: competence in Information technology, Robotics, Nanotechnology, Enabling Technology/Research & Development
QuickTime™ and aTIFF (Uncompressed) decompressor
are needed to see this picture.
27
Institut Pasteur de Shanghai /Chinese Academy of Sciences
Created in 2004
Staff : up to 160 people
RESEARCH :
• Virology : Emerging viral diseases : SARS, bird flu, HIV/AIDS, hepatitis
• encephalitis, hemorrhagic fevers
• Immunology
• Epidemiology
28
Hong-Kong University - Pasteur Research Centre
Created in 2000
Staff : 20 people
RESEARCH :
• Emerging viral diseases: SARS, bird flu
•Hepatitis C & HIV
QuickTime™ and aTIFF (Uncompressed) decompressor
are needed to see this picture.
QuickTime™ and aTIFF (Uncompressed) decompressor
are needed to see this picture.
29
Instituts Pasteur in Vietnam
IP Saigon 1891 (A. Calmette)
IP Nha Trang 1895 (A. Yersin)
IP Hanoi 1926 (N. Bernard) -> NIHE
Staff : >500 people Vietnamese Ministry of Health
RESEARCH :
• Prevention and treatment of infectious diseases
• Emerging viral diseases: SARS, Avian Influenza (H5N1), Encephalitis
•Bacterial diseases
•Dengue Fever/Medical Entomology
• Hepatitis C HIV/AIDS
•Vaccine production
30
Institut Pasteur of Cambodia
Created in 1927
Staff : 100 people
RESEARCH :
• Prevention and treatment of infectious diseases
• Emerging viral diseases: SARS, bird flu
• HIV/AIDS
•Dengue
•Mycobacterium spp. Infections
•Malaria
31
Institut Institut Pasteur Laos within Lao National Biomedical CampusPasteur Laos within Lao National Biomedical Campus
IP Laos is a Lao National Research Institute
Research mandate on Emerging Viruses, Vector-Borne Disease and Environmental Impact on Human Disease
Institut Pasteur Laos is funded by Institut Pasteur and the International Donor Community: European Commission, Luxembourg Government, French Government, Asian Development Bank.
32
Installation of BSL3
facilities provides necessary
bio-security to identify and
investigate
dangerous
infectious agents
Institut Pasteur Network in Asia
Installation of Level 3 Bio-security laboratoriesin IP Network Institutes in Asia:
33
A task force on severe acute respiratory A task force on severe acute respiratory infections and emerging virusesinfections and emerging viruses
Instituts Instituts Pasteur Paris, Cambodia, Korea, Pasteur Paris, Cambodia, Korea, Hong Kong, Shanghai, Vietnam, Laos,Hong Kong, Shanghai, Vietnam, Laos,
Objectives :Objectives :
1/ 1/ Novel diagnostics toolsNovel diagnostics tools for Acute Respiratory Infections
2/ 2/ SurveillanceSurveillance, , identification, characterization and epidemiology of newly emerging virusesin human populations
3/ New 3/ New antiviraantiviral drugsl drugs
4/ New candidate 4/ New candidate vaccinesvaccines
5/ Teaching and 5/ Teaching and trainingtraining
34
RResearchesearch--driven Rdriven Respesponse to onse to AAcute cute RRespiratory espiratory IInfectionsnfections””, acronym RESPARI., acronym RESPARI.
••This research program aims to study This research program aims to study the following aspects of acute the following aspects of acute respiratory infections (ARI) of viral respiratory infections (ARI) of viral origin (H5N1, SARS etc.)origin (H5N1, SARS etc.)
•(1) standardized diagnosis and surveillance in humans and animals
• (2) epidemiology & natural history of infectious agents (Risk Factors, Reservoirs, Modes of Transmission).
• (3) the development of new diagnostic tools, based on biotechnologies (pseudo-particles, quantum dots, molecular beacons)
QuickTime™ and aTIFF (Uncompressed) decompressor
are needed to see this picture.
35
IP Network is reinforcing Avian IP Network is reinforcing Avian Influenza research in the regionInfluenza research in the region
•Cambodia, Laos, Vietnam and China
• REINFORCING DIAGNOSTICS, SURVEILLANCE& RAPID RESPONSE
Ability to detect and contain an outbreak at the source
•DATA COLLECTION / DATA MANAGEMENT / H5N1 SAMPLE SHARING/DATA SHARING
Working closely with Regional Ministries of Health and WHO for Data Collection/ Data Management and Data and Sample sharing.
36
IP Network is reinforcing Avian Influenza research in the region
•Cambodia, Laos, Vietnam and China
•ENHANCING RESEARCH CAPACITY BUILDING We are actively participating in capacity building through-out the region through training and participative research projects not just sample collection.
•PUBLIC AWARENESSIP Network encourages media campaigns to improve public awareness
37
Putative Putative Biotechnological Biotechnological Applications Applications may be may be derived from derived from IP Network RESPARIIP Network RESPARI programprogram
••National Institute of Hygiene and Epidemiology, (NIHE) HanoiNational Institute of Hygiene and Epidemiology, (NIHE) Hanoi
in collaboration with IMSUT Tokyo Universityin collaboration with IMSUT Tokyo University
••Institut Pasteur Ho Chi Institut Pasteur Ho Chi Minh Minh City (IPHCMC)City (IPHCMC)QuickTime™ and a
TIFF (Uncompressed) decompressorare needed to see this picture.
QuickTime™ and aTIFF (Uncompressed) decompressor
are needed to see this picture.QuickTime™ and a
TIFF (Uncompressed) decompressorare needed to see this picture.
QuickTime™ and aTIFF (Uncompressed) decompressor
are needed to see this picture.
AI H5N1Vaccine Production
38
Biotechnological Biotechnological Applications Applications derived from derived from IP IP Network RESPARINetwork RESPARI programprogram
•• Institut Pasteur Shanghai (IPS)Institut Pasteur Shanghai (IPS)
•• CentreCentre Pasteur Pasteur at Hong at Hong Kong Kong University University (HKU(HKU--PRCPRC))
•• Institut Pasteur Institut Pasteur KoreaKorea (IPK, (IPK, South KoreaSouth Korea))
QuickTime™ and aTIFF (Uncompressed) decompressor
are needed to see this picture.
QuickTime™ and aTIFF (Uncompressed) decompressor
are needed to see this picture.
Avian Influenza A H5N1
-- RAPID DIAGNOSTICSRAPID DIAGNOSTICS-- DRUG SCREENINGDRUG SCREENING
QuickTime™ and aTIFF (Uncompressed) decompressor
are needed to see this picture.
Teaching and Training
worldwide
Teaching and training
Institut Pasteur has always been a pioneer in teaching new scientific disciplines1889 : First course on MicrobiologyToday : 12 Master’s courses every year
800 students and internsfrom over 60 countries are trained each year in the Institute laboratories.
41
Teaching and capacity building
Training and teaching of personnel within Institut Pasteur Network
Examples of courses in 2006-2007
• Pasteur-Asia Virology Course :HKU-Pasteur,Hong-Kong
• Malaria course : Institut Pasteur Madagascar
• Bio-Safety and BSL3 level pathogenic agents:Institut Pasteur Shanghai
• Bioinformatics Institut Pasteur Dakar
• Rabies Diagnostics Institut Pasteur Ho Chi Minh City
Institut Pasteur : 2008-2011
In 2008 : celebration of 120 years of Institut PasteurIn 2009 : Institut Pasteur Laos operational
In 2010-2011 : project to create a new research center devoted to: « Integrative Biology of Emerging Diseases »
43
www.pasteur.fr
www.pasteur-international.org