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Hôpitaux
Universitaires
Genève
Innovations in multimodality
imaging devices
Habib Zaidi1,2,3
1Geneva University Hospital, Geneva, Switzerland 2University of Groningen, Groningen, Nethelands 3University of Southern Denmark, Odense, Denmark
Email: [email protected]
Web: http://pinlab.hcuge.ch
3rd Global Forum on Medical Devices, 10-12 May 2017
Convergence of multiple image-capture techniques, basic cell/molecular
biology, chemistry, medicine, pharmacology, medical physics,
biomathematics, and bioinformatics into a new imaging paradigm
Anatomic Physiologic Metabolic Molecular
PET/SPECT
x-ray CT
MRI
ultrasound
optical imaging
Molecular Imaging: Interdisciplinary!
From 2-D to 5-D multimodality imaging
5-D PET/CT
2-D projections
3-D CT
4-D CT
4-D PET
3-D PET
Zaidi H. Navigating beyond the 6th dimension: A challenge in the era of multi-parametric molecular imaging (2009) EJNMMI 36: 1025-28
Navigating beyond the 5th dimension …
Beyond pretty images …
Early references to emission/transmission imaging
Mayneord WV (1952) The radiology of the human body with radioactive isotopes. Br J Radiol 25: 517-525 Kuhl DE, J Hale, WL Eaton (1966) Transmission scanning: A useful adjunct to conventional emission scanning for accurately keying isotope deposition to radiographic anatomy. Radiology 87: 278-284 Anger HO, J McRae (1968) Transmission scintiphotography. J Nucl Med 9: 267-269 Sorenson JA, RC Briggs, JR Cameron (1969) 99mTc Point Source for Transmission Scanning. J Nucl Med 10: 252-253 Tothill P, JM Galt (1971) Quantitative profile scanning for the measurement of organ radioactivity. Phys Med Biol 16: 625-634 Budinger TF, GT Gullberg (1974) Three-dimensional reconstruction in nuclear medicine emission imaging. IEEE Trans Nucl Sci 21: 2-20
Description of a Simultaneous Emission-Transmission CT System Hasegawa BH et al SPIE Vol 1231 Medical Imaging IV Image Formation (1990)
UCSF Emission/Transmission CT (1993)
HPGe detector
LN2 cryostat
X-ray tube
Correlated Image
CT
X-Ray CT Radionuclide Emission
SPECT
Computer
Courtesy Dr Bruce Hasegawa
1951-2008
Anatomy
(CT)
Fusion
(SPECT/CT)
+
=
Function
(SPECT)
Scout Spiral CT PET PET/CT
Principles of PET/CT
Trimodality m PET/m SPECT/m CT
FLEX Triumph™ Tri-modality system
LabPET ™ - Gamma Medica
LabPETTM ~1 mm
Benefits of combined PET/MRI
Direct and accurate registration of molecular PET signal with high
resolution MR anatomy
Better soft tissue contrast than CT
No radiation dose
Anatomically-guided reconstruction of PET data
Improved quantification of PET data
Time correlation of PET and MRI or MRS signal
Interventional, therapeutic studies
Dual-labeled agents (64Cu, Gd)
Dual-agent molecular imaging/cell tracking
Reduced positron range – improvements in the in-plane spatial
resolution (high b+ energy)
Potential designs of combined PET-MRI
Full integration
Sequential (Tandem/docked)
PET insert within MRI
Zaidi and Del Guerra (2011) Med Phys
Commercially available PET-MRI scanners
GE SIGNA PET/MR
Patient Transfer Table Top (PTTP) PET/CT MRI
Clinical whole-body PET/MRI
SIGNA PET/MR
GEMINI TF PET/MR Biograph mMR
Summary
PET/MR is producing challenges in terms of software/hardware
development but also plenty of opportunities.
MR sequences is the key for providing answers to a number of
issues.
Existing approaches previously developed in PET/CT multimodality
imaging may be explored within the PET/MR field.
New software developments are necessary to efficiently explore the
multitude of information that may be available from PET/MR.
Presently available multimodality imaging systems:
PET/CT, SPECT/CT, PET/SPECT, PET/SPECT/CT, PET/MRI,
PET/Optical
From PET/CT … to PET-MR
Will PET/MRI replace PET/CT?
Zaidi and Mawlawi Med Phys 34: 1525-1528 (2007)
Clinical applications of PET-MRI
Still the bottleneck of PET-MRI …
