Injury Research CenterProgram and Projects

Stephen Hargarten, MD, MPHDirector, Injury Research CenterProfessor and Chair, Emergency MedicineAssociate Dean, Global Health

OVERVIEWOVERVIEW

Injury Research Definition of InjuryWhy Conduct Injury Research?Leading Causes of Injury-Related Death in WisconsinBrief Background of the IRC’s Program

Research Categories

Current and Previously Funded Projects

Definition of Injury:Definition of Injury:

Physical damage due to the transfer of energy:

KineticChemicalThermalRadiationElectrical

Each day approximately 480 people in the United States die from injuries caused by motor vehicle crashes, falls, firearms, and poisonings. Unintentional and violence-related injuries are a major cause of premature death and disability, medical costs, and lost productivity for people of and injuries are the number one killer of children and younger adults. Each day approximately 480 people in the United States die from injuries caused by motor vehicle crashes, falls, firearms, and poisonings. Unintentional and violence-related injuries are a major cause of premature death and disability, medical costs, and lost productivity for people of and injuries are the number one killer of children and younger adults.

Why Conduct Injury Research?Why Conduct Injury Research?

Injury is the No. 1 killer of children andyoung adults

Injuries are a major cause of premature death and

disability, medical costs, and lost productivity

2008 Leading Causes of2008 Leading Causes ofInjury-Related Deaths in Injury-Related Deaths in Wisconsin:Wisconsin:

Falls (918)Suicide (737)Motor Vehicle Crashes (581)Poisoning (481)Homicide (151)

Brief Background of the IRC:Brief Background of the IRC:

Established to address the burden of injury

Funded in 2000 with a Grant from the CDC

Competed successfully for Renewal in 2007

Preparing for next Competitive Renewal in 2011

Learn more … Visit www.mcw.edu/irc

Interdepartmental Interdepartmental Collaboration:Collaboration:Academic AffairsCell Biology, Neurobiology and AnatomyEmergency MedicineFamily and Community MedicineInstitute for Health and SocietyMedicine/GeriatricsNeurosurgeryPathologyPediatricsPhysical Medicine & RehabilitationPlastic SurgerySurgery

Research Categories:Research Categories:

Acute Injury CareBiomechanicsCommunity Prevention ProgramsPoisoningPolicyPost Traumatic Stress DisorderSports, Recreation and ExerciseSexual Violence and Intimate Partner ViolenceSuicide PreventionTransportationTraumatic Brain InjuryViolence Prevention

Current Grant CycleCurrent Grant CycleCDC Funded Research ProjectsCDC Funded Research ProjectsLarge Project (5 Years): Facilitating Dissemination of Injury Interventions: A Randomized TrialPI: Peter M. Layde, MD, MSc, Professor Emergency Medicine

 Investigation of how effective injury prevention research can be

disseminatedand broadly implemented in communities. Collaborating with local

publichealth departments and county aging units in Wisconsin to broadlyimplement evidence-based fall prevention programs.

Overall Goal: Impacting an entire community vs. the small number ofolder adults who currently participate in fall prevention activities

Current Grant CycleCurrent Grant CycleCDC Funded Research Projects CDC Funded Research Projects (Cont’d)(Cont’d)Small Project (3 Years): Healthcare Can Change From Within to End Intimate Partner Violence: A Rigorous Evaluation PI: L. Kevin Hamberger, PhD, Professor Family and Community Medicine

 Rigorous evaluation of program’s impact on the prevention of future

violence,safety, health status, and sense of community connectedness of

batteredwomen over a 24-month follow-up period.

Primary Goal: Train health care providers to screen, identify, help victims,

and prevent intimate partner violence

Previously Funded ResearchPreviously Funded Research

Seed Projects: 2002-200711 Projects Funded with CDC Dollars

2008-20107 Projects Funded with AHW Dollars

Seed Projects- AHW Funding in Seed Projects- AHW Funding in 20102010

Contribution of Muscle Injury vs. Nerve Injury to Neuropathic Pain

PI: Cheryl Stuckey PhD, Associate Professor Cell Biology, Neurobiology, and Anatomy

Effect of Early Rest on Recovery from Pediatric ConcussionPI: Danny Thomas, MD Associate Professor Emergency Medicine

Establish a Rodent Model for Blast Traumatic Brain Injury Study

PI: Jiangyue Zhang, PhD, Assistant Professor Neurosurgery

Seed Projects - AHW Funding in Seed Projects - AHW Funding in 20092009

Development of a Study of EMS Findings Predictive ofPediatric Trauma Center Need

PI: Brooke Lerner, PhD Associate ProfessorEmergency Medicine

New Paradigms in Diagnosis and Treatment of PeripheralNerve Injury Using Functional Magnetic Imaging and RoboticsPI: Christopher Pawela, PhD, Assistant Professor Plastic Surgery

Seed Projects – AHW Funding in Seed Projects – AHW Funding in 20082008

Initial Development of a Trauma-Specific Quality of Life Instrument

PI: Karen Brasel, MD, MPH Associate ProfessorSurgery/Trauma & Critical Care

The Ability of Existing Automotive Seats to Protect At-RiskOccupants in Rear ImpactsPI: Brian Stemper, PhD Assistant Professor Neurosurgery

Seed Projects - CDC Funding in Seed Projects - CDC Funding in 20072007

Modeling Mechanisms of Skull Base Trauma in Motor VehicleCollisionsPI: John Rhee, MD Associate Professor Otolaryngology

Examination of Wisconsin’s New Child Passenger SafetyLegislationPI: Suzanne Brixey, MD Assistant Professor Pediatrics

Seed Project - CDC Funding in Seed Project - CDC Funding in 20052005

Affecting Use Rate of Child Passenger Restraints in MilwaukeePI: Suzanne Brixey, MD Assistant Professor Pediatrics

Seed Projects - CDC Funding in Seed Projects - CDC Funding in 20042004

Automotive Components Associated with Thoracic InjuryPI: Raminder Nirula, MD, MPH Assistant Professor Surgery/Trauma & Critical Care

Analysis of How Unintentional Injury is Reported on TVPI: James Pribble, MD Emergency Medicine University of Michigan – Ann Arbor

OSCE to Test MD Ability in Partner Violence ScreeningPI: Marie Wolff, PhD Associate Professor Family and Community Medicine

Seed Projects - CDC Funding in Seed Projects - CDC Funding in 20032003

Validity of Neuron Specific Enolase and S100B Serum Levelsin Predicting Neurocognitive and Behavioral Outcomes inChildren With Moderate to Severe Closed TBI PI: Subhankar Bandyopadhyay, MD, Assistant Professor Pediatric Emergency Medicine

Development of a Human Surrogate System: Fall-related Injury Prevention ResearchPI: Kyu-Jung Kim, PhD Assistant Professor College of Engineering and Applied Science – UW-Milwaukee

Seed Projects - CDC Funding in Seed Projects - CDC Funding in 20032003(Cont’d)(Cont’d)Pediatric Emergency Department Child Abuse StudyPI: Demetrios Kyriacou, MD, PhD, MPH Associate Professor Preventative Medicine – Northwestern University, Chicago

Child Fall Injury Patterns in an Inner City NeighborhoodPI: Karen Bruner Stroup, PhD Director of Pediatrics Community Education & Child Advocacy Riley Hospital for Children - Indianapolis

Seed Project - CDC Funding in Seed Project - CDC Funding in 20022002

Mechanisms of Ankle Fractures with Syndesmotic Involvement

PI: Richard Marks, MD Associate Professor Orthopaedic Surgery

Potential Funding SourcesPotential Funding SourcesCenters for Disease Control and Prevention (CDC)http://www.cdc.gov/injury/erpo/Funding/index.html

Department of Defense (DOD)

Department of Transportation (DOT)

National Highway and Traffic Safety Administration (NHTSA)

National Institutes of Health (NIH)

National Institute of Occupational Safety and Health (NIOSH)

Robert Wood Johnson (RWJ)http://www.rwjf.org/applications/whatwefund.jsp