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Inhibition of Hsp90 with Synthetic Macrolactones: Synthesis and Structural and Biological Evaluation of Ring and Conformational Analogs of Radicicol Nicolas Proisy, Swee Y. Sharp, Kathy Boxall, Stephen Connelly, S. Mark Roe, Chrisostomos Prodromou, Alexandra M.Z. Slawin, Laurence H. Pearl, Paul Workman, Christopher J. Moody Chemistry & Biology Volume 13, Issue 11, Pages 1203-1215 (November 2006) DOI: 10.1016/j.chembiol.2006.09.015 Copyright © 2006 Elsevier Ltd Terms and Conditions

Inhibition of Hsp90 with Synthetic Macrolactones: Synthesis and Structural and Biological Evaluation of Ring and Conformational Analogs of Radicicol Nicolas

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Page 1: Inhibition of Hsp90 with Synthetic Macrolactones: Synthesis and Structural and Biological Evaluation of Ring and Conformational Analogs of Radicicol Nicolas

Inhibition of Hsp90 with Synthetic Macrolactones: Synthesis and Structural and Biological Evaluation of Ring and Conformational Analogs of Radicicol 

Nicolas Proisy, Swee Y. Sharp, Kathy Boxall, Stephen Connelly, S. Mark Roe, Chrisostomos Prodromou, Alexandra M.Z. Slawin, Laurence H. Pearl, Paul Workman, Christopher J. Moody 

Chemistry & Biology Volume 13, Issue 11, Pages 1203-1215 (November 2006)

DOI: 10.1016/j.chembiol.2006.09.015

Copyright © 2006 Elsevier Ltd Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 2: Inhibition of Hsp90 with Synthetic Macrolactones: Synthesis and Structural and Biological Evaluation of Ring and Conformational Analogs of Radicicol Nicolas

Figure 1

Chemistry & Biology 2006 13, 1203-1215DOI: (10.1016/j.chembiol.2006.09.015) Copyright © 2006 Elsevier Ltd Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 3: Inhibition of Hsp90 with Synthetic Macrolactones: Synthesis and Structural and Biological Evaluation of Ring and Conformational Analogs of Radicicol Nicolas

Figure 2

Chemistry & Biology 2006 13, 1203-1215DOI: (10.1016/j.chembiol.2006.09.015) Copyright © 2006 Elsevier Ltd Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 4: Inhibition of Hsp90 with Synthetic Macrolactones: Synthesis and Structural and Biological Evaluation of Ring and Conformational Analogs of Radicicol Nicolas

Figure 3

Chemistry & Biology 2006 13, 1203-1215DOI: (10.1016/j.chembiol.2006.09.015) Copyright © 2006 Elsevier Ltd Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 5: Inhibition of Hsp90 with Synthetic Macrolactones: Synthesis and Structural and Biological Evaluation of Ring and Conformational Analogs of Radicicol Nicolas

Figure 4

Chemistry & Biology 2006 13, 1203-1215DOI: (10.1016/j.chembiol.2006.09.015) Copyright © 2006 Elsevier Ltd Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 6: Inhibition of Hsp90 with Synthetic Macrolactones: Synthesis and Structural and Biological Evaluation of Ring and Conformational Analogs of Radicicol Nicolas

Figure 5

Chemistry & Biology 2006 13, 1203-1215DOI: (10.1016/j.chembiol.2006.09.015) Copyright © 2006 Elsevier Ltd Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 7: Inhibition of Hsp90 with Synthetic Macrolactones: Synthesis and Structural and Biological Evaluation of Ring and Conformational Analogs of Radicicol Nicolas

Figure 6

Chemistry & Biology 2006 13, 1203-1215DOI: (10.1016/j.chembiol.2006.09.015) Copyright © 2006 Elsevier Ltd Terms and Conditions

http://www.elsevier.com/termsandconditions

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