Infraredx-Related PublicationsOriginal Peer-Reviewed Articles

1. Pu J, Mintz GS, Biro S, et al. Insights Into Echo-Attenuated Plaques, Echolucent Plaques, and Plaques With Spotty Calcification: Novel Findings From Comparisons Among Intravascular Ultrasound, Near-Infrared Spectroscopy, and Pathological Histology in 2,294 Human Coronary Artery Segments. J Am Coll Cardiol. 2014;63(21):2220-2233.

2. Ueda Y, Matsuo K, Nishimoto Y, et al. Detection of yellow plaque by near-infrared spectroscopy - Comparison with coronary angiography in a case of no-flow phenomenon during coronary intervention. J Cardiol Cases. 2014. [In press]

3. Madder RD, Wohns DH, Muller JE. Detection by Intracoronary Near-Infrared Spectroscopy of Lipid Core Plaque at Culprit Sites in Survivors of Cardiac Arrest. J Invasive Cardiol. 2014;26(2):78-79.

4. Madder RD, Goldstein JA, Madden SP, et al. Detection by Near-infrared Spectroscopy of Large Lipid Core Plaques at Culprit Sites in Patients with Acute ST-Segment Elevation Myocardial Infarction. J Am Coll Cardiol Intv. 2013. 6 (8):838-846.

5. de Boer SP, Brugaletta S, Garcia-Garcia HM, et al. Determinants of high cardiovascular risk in relation to plaque-composition of a non-culprit coronary segment visualized by near-infrared spectroscopy in patients undergoing percutaneous coronary intervention. Eur Heart J. 2013 Sep 12. [Epub ahead of print]

6. Choi BJ, Prasad A, Gulati R, et al. Coronary Endothelial Dysfunction in Patients with Early Coronary Artery Disease is Associated with the Increase in Intravascular Lipid Core Plaque. Eur Heart J. 2013. July; 34 (27): 2047-2054.

7. Yonetsu T, Suh W, Abtahian F, Kato K, Vergallo R, Kim SJ, Jia H, McNulty I, Lee H, Jang IK. Comparison of near-infrared spectroscopy and optical coherence tomography for detection of lipid. Catheter Cardiovasc Interv. 2013 Jun 19.

8. Ali ZA, Roleder T, Narula J, et al. Increased Thin-Cap Neoatheroma and Periprocedural Myocardial Infarction in Drug-Eluting Stent Restenosis Multimodality Intravascular Imaging of Drug-Eluting and Bare-Metal Stents. Circ Cardiovasc Interv. 2013 Sep 24. [Epub ahead of print]

9. Maini A, Buyantseva L, Maini B. In vivo lipid core plaque modification with percutaneous coronary revascularization: a near-infrared spectroscopy study. J Invasive Cardiol. 2013 Jun;25(6):293-5.

10. Townsend JC, Steinberg DH, Nielsen CD, et al. Comparison of Lipid Deposition at Coronary Bifurcations Versus at Non-bifurcation Portions of Coronary Arteries as Determined by Near-infrared Spectroscopy. Am J Cardiol. 2013. 112 (3):369-372.

11. Kini AS, Baber U, Kovacic JC, et al. Changes in Plaque Lipid Content After Short-Term Intensive Versus Standard Statin Therapy: The YELLOW Trial (Reduction in Yellow Plaque by Aggressive Lipid-Lowering Therapy). J Am Coll Cardiol. 2013; 62(1):21-29.

12. Sharma R, Roleder T, Ali Z, et al. Lipid-Rich Versus Fibrous Intimal Hyperplasia in Transplant Vasculopathy. J Am Coll Cardiol Img. 2013; 6(1): 126-127.

13. Patel D, Hamamdzic D, Llano R, et al. Subsequent Development of Fibroatheromas With Inflamed Fibrous Caps Can Be Predicted by Intracoronary Near Infrared Spectroscopy. Arterioscler Thromb Vasc Biol. 2013;33:347-353. [Epub 3 Jan 2013]

14. Papayannis AC, Abdel-Karim AR, Mahmood A, et al. Association of coronary lipid core plaque with intrastent thrombus formation: A Near-Infrared Spectroscopy and Optical Coherence Tomography Study. Catheter Cardiovasc Interv. 2013 Feb;81(3);488-493. [Epub 10 Jan 2012]

15. Brugaletta S, Garcia-Garcia HM, Serruys PW, et al. Distance of Lipid Core-Rich Plaques From The Ostium By NIRS In Nonculprit Coronary Arteries. J Am Coll Cardiol Img. 2012;3:297-9.

16. Mostofsky E, Maclure M, Sherwood JB, Tofler GH, Muller JE, Mittleman MA. Risk of Acute Myocardial Infarction After the Death of a Significant Person in One's Life: The Determinants of Myocardial Infarction Onset Study. Circulation. 2012;125: 491-496.

17. Brilakis ES, Abdel-Karim AR, Maini B, et al. Embolic Protection Device Utilization During Stenting of Native Coronary Artery Lesions with Large Lipid Core Plaques As Detected By Near-Infrared Spectroscopy. Catheter Cardiovasc Interv. 2012 Dec 1;80(7):1157-62.

18. Madder RD, Smith JL, Dixon SR, Goldstein JA. Composition of Target Lesions by Near-Infrared Spectroscopy in Patients With Acute Coronary Syndrome Versus Stable Angina. Circ Cardiovasc Interv. 2012;5:55-61.

19. Zynda TK, Thompson CD, Hoang KC, et al. Disparity between Angiographic Coronary Lesion Complexity and Lipid Core Plaques Assessed by Near Infrared Spectroscopy. Catheter Cardiovasc Interv. 2013;81(3):529-537. [Epub 25 Apr 2012]

20. Dixon SR, Grines CL, Munir A, et al. Analysis of Target Lesion Length Prior to Coronary Artery Stenting Using Angiography and Near-Infrared Spectroscopy versus

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Angiography Alone: Implications for Complete Lesion Coverage. Am J Cardiol. 2012;109:60-66.

21. Raghunathan D, Abdel-karim A, Papyannis A, et al. Relation between the Presence and Extent of Coronary Lipid Core Plaques Detected by Near-Infrared Spectroscopy with Postpercutaneous Intervention Myocardial Infarction. Am J Cardiol. 2011; 107:1613-1618.

22. Goldstein JA, Maini B, Dixon SR, Brilakis et al. Detection of Lipid-core Plaques by Intra-coronary Near-infrared Spectroscopy Identifies High Risk of Peri-Procedural Myocardial Infarction. Circ Cardiovasc Interv. 2011 Oct 1;4(5):429-37.

23. Madder RD, Steinberg DH, Anderson RD. Multimodality Direct Coronary Imaging with Combined Near-Infrared Spectroscopy and Intravascular Ultrasound: Initial US Experience. Catheter Cardiovasc Interv.2013 Feb;81(3):551-7. [Epub 2012 Jan 10]

24. Brugaletta S, Garcia-Garcia HM, Serruys PW, et al. NIRS and IVUS for Characterization of Atherosclerosis in Patients Undergoing Coronary Angiography. J Am Coll Cardiol Img. 2011;4;647-655.

25. Papayannis AC, Banerjee S, Brilakis ES. Multimodality imaging of a myocardial infarction culprit lesion. Hellenic J Cardiol. 2011 Nov;52(6):536-7.

26. Pu J, Mintz GS, Brilakis ES, et al. In vivo characterization of coronary plaques: novel findings from comparing greyscale and virtual histology intravascular ultrasound and near-infrared spectroscopy. Eur Heart J. 2012 Feb;33(3):372-83. [Epub 20 Oct 2011]

27. Garg S, Serruys PW, van der Ent M, et al: First use in patients of a combined near infra-red spectroscopy and intra-vascular ultrasound catheter to identify composition and structure of coronary plaque. EuroIntervention. 2010;5:755-756.

28. Schultz C, Serruys PW, van der Ent M, et al. First-In-Man Clinical Use of Combined Near-Infrared Spectroscopy and Intravascular Ultrasound: - a potential key to predict distal embolization and no reflow? J Am Coll Cardiol. 2010; 56:314.

29. Garcia B A, Wood F, Cipher D, Banerjee S, Brilakis E S. Reproducibility of near-infrared spectroscopy for the detection of lipid core coronary plaques and observed changes after coronary stent implantation. Catheter Cardiovasc Interv. 2010;76(3):359–365.

30. Abdel-karim A-R, Rangan BV, Banerjee S Brilakis ES. Inter-catheter reproducibility of near-infrared spectroscopy for the in-vivo detection of coronary lipid core coronary plaque. Catheter Cardiovasc Interv. 2011 Apr 1;77(5):657-61. [Epub 8Mar 2011]

31. Wood FO, Badhey N, Garcia B, et al. Analysis of saphenous vein graft lesion composition using near-infrared spectroscopy and intravascular ultrasonography with virtual histology. Atherosclerosis. October 2010; 212(2): 528-533.

32. Sakhuja R, Suh W, Jaffer FA, Jang IK. Residual Thrombogenic Substrate After Rupture of a Lipid-Rich Plaque: Possible Mechanism of Acute Stent Thrombosis? Cirulation. 2010;122:2349-2350.

33. Saeed B, Banerjee S, Brilakis E. Slow flow after stenting of a coronary lesion with a large lipid core plaque detected by near-infrared spectroscopy. EuroIntervention. 2010;6:545.

34. Wentzel JJ, van der Giessen AG, Garg S, et al. In vivo 3D distribution of lipid-core plaque in human coronary artery as assessed by fusion of near infrared spectroscopy-intravascular ultrasound and multislice computed tomography scan. Circ Cardiovasc Imaging. 2010 Nov 1;3(6):e6-7.

35. Waxman S, Simon R. Dixon, L'Allier P, et al. In Vivo Validation of a Catheter-Based Near-Infrared Spectroscopy System for Detection of Lipid Core Coronary Plaques: Initial Results of the SPECTACL Study. J Am Coll Cardiol Img. 2009;2:858-868.

36. Goldstein JA, Grines C, Fischell T, et al. Coronary embolization following balloon dilation of lipid-core plaques J Am Coll Cardiol Img.2009;2:1420-1424.

37. Gardner CM, Tan H, Hull EL, et al. Detection of Lipid Core Coronary Plaques in Autopsy Specimens With a Novel Catheter-Based Near-Infrared Spectroscopy System. J Am Coll Cardiol Img. 2008;1(5):638-648.

38. Waxman S, Khabbaz K, Connolly R, et al. Intravascular imaging of atherosclerotic human coronaries in a porcine model: a feasibility study. The International Journal of Cardiovascular Imaging (formerly Cardiac Imaging). 2008;24(1):37-44.

39. Cheruvu PK, Finn AV, Gardner CM, et al. Frequency and Distribution of Thin-Cap Fibroatheroma and Ruptured Plaques in Human Coronary Arteries: A Pathologic Study. J Am Coll Cardiol. 2007;50(10):940-949.

40. Bosch JL, Beinfeld MT, Muller JE, Brady T, Gazelle GS. A Cost-Effectiveness Analysis of a Hypothetical Catheter-Based Strategy for the Detection and Treatment of Vulnerable Coronary Plaques with Drug-Eluting Stents. J Interv Cardiol. 2005;18(5):339-349.

41. Moreno PR, Purushothaman KR, Fuster V, et al. Plaque Neovascularization Is Increased in Ruptured Atherosclerotic Lesions of Human Aorta Implications for Plaque Vulnerability. Circulation. 2004;110:2032-2038.

42. Schaar JA, Muller JE, Falk E, et al. Terminology for high-risk and vulnerable coronary artery plaques. Report of a

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meeting on the vulnerable plaque, June 17 and 18, 2003, Santorini, Greece. Eur Heart J. 2004;25(12):1077-82.

43. Moreno P, Muller J. Detection of High-Risk Atherosclerotic Coronary Plaques by Intravascular Spectroscopy. J Interv Cardiol. 2003;16(3):243-252.

44. Urbas A, Manning MW, Daugherty A, et al. Near-Infrared Spectrometry of Abdominal Aortic Aneurysm in the ApoE-/- Mouse. Anal Chem. 2003;75(14):3318-3323.

45. Neumeister V, Scheibe M, Lattke P, Jaross W. Determination of the cholesterol–collagen ratio of arterial atherosclerotic plaques using near infrared spectroscopy as a possible measure of plaque stability. Atherosclerosis. 2002;165(2):251-257.

46. Moreno PR, Lodder RA, Purushothaman KR, et al. Detection of Lipid Pool, Thin Fibrous Cap, and Inflammatory Cells in Human Aortic Atherosclerotic Plaques by Near-Infrared Spectroscopy. Circulation. 2002;105(8):923-927.

47. Wang J, Geng Y, Guo B, et al. Near-infrared spectroscopic characterization of human advanced atherosclerotic plaques. J Am Coll Cardiol. 2002;39(8):1305-1313.

48. Jaross W, Neumeister V, Lattke P, Schuh D. Determination of cholesterol in atherosclerotic plaques using near infrared diffuse reflection spectroscopy. Atherosclerosis. 1999;147(2):327-337.

49. Waxman S, Mittleman M, Zarich S, et al. Angioscopic assessment of coronary lesions underlying thrombosis. Am J Cardiol. 1997;79:1106-1109.

50. Muller JE, Mittleman M, Maclure M, et al. Triggering of myocardial infarction by sexual activity: Low absolute risk and prevention by regular physical exertion. . J Am Med Assoc. 1996;275:1405-1409.

51. Waxman S, Sassower M, Mittleman M, et al. Angioscopic predictors of early adverse outcome after coronary angioplasty in patients with unstable angina and non-Q-wave myocardial infarction. Circulation. 1996;93:2106-2113.

52. Mittleman M, Maclure M, Sherwood J, et al. Triggering of acute myocardial infarction onset by episodes of anger. Circulation. 1995;92:1720-1725.

53. Muller JE, Abela G, Nesto R, Tofler G. Triggers, acute risk factors, and vulnerable plaques: The lexicon of a new frontier. J Am Coll Cardiol. 1994;23:809-813.

54. Cassis LA, Lodder RA. Near-IR imaging of atheromas in living arterial tissue. Anal Chem. 1993;65(9):1247-1256.

55. Mittleman M, Maclure M, Tofler G, et al. Triggering of acute myocardial infarction by heavy physical exertion: Protection against triggering by regular exertion. N Engl J Med. 1993;329:1677-1683.

56. Willich S, Goldberg R, Maclure M, Perriello L, Muller JE. Increased onset of sudden cardiac death in the first three hours after awakening. Am J Cardiol. 1992;70:65-68.

57. Lodder RA, Cassis L, Ciurczak EW. Arterial Analysis with a Novel Near-IR Fiber-Optic Probe. Spectroscopy.1990;5:12-17.

58. Tofler G, Stone PH, Maclure M, et al. Analysis of possible triggers of acute myocardial infarction (The MILIS Study). Am J Cardiol. 1990;66:22-27.

59. Lodder RA, Hieftje GM, Moorehead W, et al. Assessment of the feasibility of determination of cholesterol and other blood constituents by near-infrared reflectance analysis. Talanta. 1989;36:193-198.

60. Marler J, Price T, Clark G, et al. Morning increase of stroke onset. Stroke. 1989;20:473-476.

61. Muller JE, Tofler GH, Stone PH. Circadian variation and triggers of onset of acute cardiovascular disease. Circulation. 1989;79:733-743.

62. Muller JE, Tofler G, Edelman E. Probable triggers of onset of acute myocardial infarction. Clin Cardiol. 1989;12:473.

63. Muller JE, Ludmer P, Willich S, et al. Circadian variation in the frequency of sudden cardiac death. Circulation. 1987;75:131-138

64. Tofler G, Brezinski D, Schafer A, et al. Concurrent morning increase in platelet aggregability and the risk of myocardial infarction and sudden cardiac death. N Engl J Med. 1987;316:1514-1518.

65. Willich S, Levy D, Rocco M, et al. Circadian variation in the incidence of sudden cardiac death in the Framingham Heart Study population. Am J Cardiol. 1987;60:801-806.

66. Muller JE, Stone PH, Turi Z, et al. Circadian variation in the frequency of onset of acute myocardial infarction. N Engl J Med. 1985;313:1315-1322.

Reviews, Book Chapters, Letters, and Editorials

1. Hanson I, Dixon S, Goldstein J. Assessing coronary target lesion length: the Goldilocks approach. Future Cardiol. 2014 Mar;10(2):179-82.

2. Tomey MI, Narula J, Kovacic JC. Advances in the Understanding of Plaque Composition and Treatment Options: Year in Review. J Am Coll Cardiol. 2014 Apr 29;63(16):1604-1616.[Epub 2014 Feb 26]

3. Fenning RS, Wilensky RL. New insights into the vulnerable plaque from imaging studies. Curr Atheroscler Rep. 2014 Mar;16(3):397. [Epub 30 Jan 2014]

4. Mintz GS. Beyond Greyscale IVUS assessment of progression/regression: it should be simple, but it's not.

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Eur Heart J Cardiovasc Imaging. 2014. [Epub 20 Jan 2014]

5. Madder R, Busman M, Banga S. Plaque Characterization to Identify Patients at High Risk of Acute Complications During PCI. Intervent Cardiol. 2013 Dec;5(6):663-672.

6. Nadkarni SK. Optical measurement of arterial mechanical properties: from atherosclerotic plaque initiation to rupture. J Biomed Opt. 2013 Dec 1;18(12):121507.

7. Patel VG, Brayton KM, Mintz GS, Maehara A, Banerjee S, Brilakis ES. Intracoronary and noninvasive imaging for prediction of distal embolization and periprocedural myocardial infarction during native coronary artery percutaneous intervention. Circ Cardiovasc Imaging. 2013 Nov 1;6(6):1102-14.

8. Giugliano RP, Braunwald E, The Year in Acute Coronary Syndrome, J Am Coll Cardiol. 2013 Oct 31.[Epub ahead of print]

9. Jaguszewski M, Klingenberg R, Landmesser U. Intracoronary Near-Infrared Spectroscopy (NIRS) Imaging for Detection of Lipid Content of Coronary Plaques: Current Experience and Future Perspectives. Curr Cardiovasc Imaging Rep. 2013. [published online 17 Aug 2013].

10. Goldstein, JA. Intravascular Characterization of Vulnerable Coronary Plaque. In: Kern, MJ editor. 2nd Edition, SCAI Interventional Cardiology Board Review. Lippincott Williams and Wilkins, 2013: 96-104.

11. Block PC. Crouching Tiger, Lipid Plaque. Catheter Cardiovasc Interv.2013;81(3):538-539.

12. Sanon S, Dao T, Sanon VP, Chilton R. Imaging of vulnerable plaques using near-infrared spectroscopy for risk stratification of atherosclerosis. Curr Atheroscler Rep. 2013 Feb;15(2):304.

13. Hildebrandt HA, Kahlert P, Baars T, Kleinbongard P, Erbel R, Heusch G. Is there a need for distal protection during native vessel percutaneous coronary intervention in patients with stable coronary artery disease? J Cardiovasc Med (Hagerstown). 2013 Jul 10. [Epub ahead of print]

14. Ng VG, Meller S, Shetty S, Lansky AJ. Diagnosing and Characterizing Coronary Artery Disease in Women: Developments in Noninvasive and Invasive Imaging Techniques. J Cardiovasc Transl Res. 2013 Aug 6. [Epub ahead of print]

15. Madder RD, Stone GW, Erlinge D, Muller JE. The Search for Vulnerable Plaque - The Pace Quickens. J Invasive Cardiol. 2013; 25:29A-33A.

16. Rizik D, Goldstein JA. NIRS-IVUS Imaging To Characterize the Composition and Structure of Coronary Plaques. J Invasive Cardiol. 2013; 25:2A-4A.

17. Shydo B, Hendricks M, Frazier G. Imaging of Plaque Composition and Structure with the TVC Imaging System and TVC Insight Catheter. J Invasive Cardiol. 2013; 25:5A-8A.

18. Fuh E, Brilakis E. Comparative Intravascular Imaging for Lipid Core Plaque: VH-IVUS vs OCT vs NIRS. J Invasive Cardiol. 2013; 25:9A-13A.

19. Goldstein JA, Dixon SR, Stone GW. NIRS-IVUS Imaging Identifies Lesions at High Risk of Peri-Procedural Myocardial Infarction. J Invasive Cardiol. 2013; 25:14A-16A.

20. Lim MJ, Stolker JM. Multiple Ruptures in Patient with ST-Segment Elevation Myocardial Infarction: Does Infrared Spectroscopy Evidence Explain a Significant Change in the Angiogram? J Invasive Cardiol. 2013; 25:16A-17A.

21. Erlinge D. Missing the Culprit Yellow Plaque. J Invasive Cardiol. 2013; 25:18A.

22. Stouffer GA. The Use of Near-Infrared Spectroscopy to Optimize Stent Length. J Invasive Cardiol. 2013; 25:19A.

23. Hanson I, Dixon S, Goldstein J. Employing NIRS-IVUS to Guide Optimal Lesion Covverage - Avoidance of Geographic Miss. J Invasive Cardiol. 2013; 25:20A-21A.

24. Karanasos A, van Soest G, Lighart JMR, Gnanadesigan M, del Trigo M, Regar E. Peri-ProceduralMyocardial Injury Unraveled: Combined Assessment by Optical Coherence Tomography, Near-Infrared Spectroscopy and IVUS. J Invasive Cardiol. 2013; 25:22A-23A.

25. Bourantas CV, Garcia-Garcia HM, Diletti R, Campos CAM, Zhang Y, Garg S, Serruys PW. Long-term Consequences of a Lipid Core Plaque. J Invasive Cardiol. 2013; 25:24A-26A.

26. Kovacic JC, Kini A. Pharmacological Therapy of Lipid Core Plaque. J Invasive Cardiol. 2013; 25:27A-28A.

27. Madder RD. Observations from Intracoronary Near-Infrared Spectroscopy in Patients with ST-Segment Elevation Myocardial Infarction. J Invasive Cardiol. 2013; 25:34A-35A.

28. Weisz G. NIRS Imaging of Cardiac Allograft Vasculopathy. J Invasive Cardiol. 2013; 25:35A-36A.

29. Puri R, Tuzcu EM, Nissen SE, Nicholls SJ. Exploring coronary atherosclerosis with intravascular imaging. Int J Cardiol. 2013 Apr 7. [Epub ahead of print]

30. Bourantas CV, Garcia-Garcia HM, Naka KK, et al. Hybrid intravascular imaging: current applications and prospective potential in the study of coronary atherosclerosis. J Am Coll Cardiol. 2013. 61(13):1369-1378.

31. Brilakis ES, He Z, Sum ST, Madden SP, Muller JE. Chemical Fingerprinting of plaque: spectroscopic techniques. In Imaging Coronary Atherosclerosis. Eds. Nicholls and Crowe. In press.

32. Van Ditzhuijzen NS, et al. Invasive imaging of the coronary atherosclerotic plaque. Minerva Cardioangiol. 2012 Jun;60(3):305-29.

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33. Brilakis ES, He Z, Sum ST, Madden SP, Muller JE. Imaging of Structure and Composition of Lipid Core Plaque with a Combination NIRS-IVUS System: Current Status and Potential Clinical Applications. In: Coronary Atherosclerosis: Current Management and Treatment 1e. Eds. Arampatzis C, McFadden EP, Michalis LK, Virmani R, Serruys P. 2012.

34. Goldstein JA, Madden SP, Sum S, Dixon SR, Madder RD, Muller JE. Intravascular Spectroscopy. In: Percutaneous Interventional Cardiovascular Medicine: The PCR-EACPI Textbook. Eds Eeckhout et al. Europa Organization. Volume I. 2012:665-680.

35. Brilakis ES, Sum ST, Madden SP, Muller JE. Intravascular Imaging of Lipid Core Plaque by Near-Infrared Spectroscopy. In: Intravascular Imaging: Current Applications and Research Developments, Eds. Tsakanikas, et al. IGI Global; 2012. p. 240-259.

36. Brugaletta S, Magro M, Simsek C, et al. Plaque Compositional Syntax Score: Combining Angiography and Lipid Burden in Coronary Artery Disease. 5;3: Suppl S119-21.

37. Brugaletta S, Garcia-Garcia H, Serruys P. Perspective on the Use of True Vessel Characterization Imaging in Interventional Cardiology Clinical Practice. Interventional Cardiology. 2012;7(1):17-20.

38. Serruys P, Brugaletta S, Garcia-Garcia H. TVC Imaging: a new tool in interventional cardiology. Hospital Healthcare Europe 2012 Cardiology.

39. Goldstein, JA. Preventing Distal Embolization: Plaque Composition is the Matter.Catheter Cardiovasc Interv. 2012 80:1163-1164. [Epub 5 December 2012.]

40. Stolker JM. Optimizing Coronary Revascularization with Near-Infrared Spectroscopy. Cardiology Today Intervention. March/April 2012.

41. Goldstein JA. Peri-Procedural MI: It’s the Plaque, Not the Stent. Catheter Cardiovasc Interv. 2012; 80:531–532.

42. Puri R, Worthley M, Nicholls S. Intravascular imaging of vulnerable coronary plaque: current and future concepts. Nat Rev Cardiol. [Epub 25 Jan 2011]

43. Liew G – PhD Thesis [May 2011 Extract]

44. Vancraeynest D, Pasquet A, Roelants V, Gerber BL, Vanoverschelde JL. Imaging the vulnerable plaque. J Am Coll Cardiol. 2011 May 17;57(20):1961-79.

45. Goldstein J, Madden S, Sum S, Dixon S, Madder R, Muller J. Assessment of Plaque Composition with Near-Infrared Spectroscopy. Curr Cardiovasc Imaging Rep. [Epub 08 Jun 2011]

46. Chilton R. Promising advances in CV imaging of lipid-rich vulnerable plaques by near-infrared spectroscopy. Catheter Cardiovasc Interv. 2011 Apr; 77(5):662-663.

47. Goldstein JA, Madden SP, Sum S, Dixon SR, Madder RD, Muller JE. Intravascular Spectroscopy. Kern MJ (Editor) Curr Cardiovasc Imaging Reports 2011.

48. Muller JE, Weissman NJ, Tuzcu EM, The Year In Intra-coronary Imaging. J Am Coll Cardiol Img. 2010;3;881-891.

49. Madden SP, Sum ST, Muller JE, Assessment of Plaque Composition with Near Infrared Spectroscopy. In:, Escaned J, Serruys PW, editors. Coronary Artery Stenosis: Imaging, Structure and Physiology. Toulouse, France: Europa Edition, 2010:245-261.

50. Garcia-Garcia HM, Costa MA, Serruys PW. Imaging of coronary atherosclerosis:intravascular ultrasound. Eur Heart J. 2010 Oct;31(20):2456-69. [Epub 7 Sep 2010]

51. Garg R, Waxman S. Catheter-Based Near-Infrared Spectroscopy for Imaging of Lipid-Rich Plaques. Curr Cardiovasc Imaging Rep. [Epub 03 Sept 2010]

52. Alsheikh-Ali AA, Kitsios GD, Balk EM, Lau J, Ip S. The vulnerable atherosclerotic plaque: scope of the literature. Ann Intern Med. 2010 Sep 21;153(6):387-95. Epub 2010 Aug 16.

53. Sharif F, Murphy RT. Current status of vulnerable plaque detection. Catheter Cardiovasc Interv. 2010 Jan 1;75(1):135-44.

54. Goldstein JA, Muller JE. Intravascular Characterization of Vulnerable Coronary Plaque. In: Naghavi M, editor. Asymptomatic Atherosclerosis:Pathophysiology, Detection and Treatment. Springer Science+Business Media LLC, 2010;461-473.

55. Brilakis ES, Goldstein JA, Powers ER, Shunk KA, Stone GW. What Should We Do About Lipid Core Plaque? The InfraReDx LipiScan IVUS and the CANARY Trial. CathLab Digest. 2010;18(11):1.

56. Fernandez-Friera L, Garcia-Alvarez A, Romero A, et al. Lipid-Rich Obstructive Coronary Lesions: Is Plaque Characterization Any Important? J Am Coll Cardiol Img. 2010; 3:893-895

57. Goldstein JA, Muller JE. Intravascular Characterization of Vulnerable Coronary Plaque. In: Naghavi M (ed). Asymptomatic Atherosclerosis: Pathophysiology, Detection and Treatment. Humana Press. 2010.

58. Bruggink JL, Meerwaldt R, van Dam GM, et al. Spectroscopy to improve identification of vulnerable plaques in cardiovascular disease. Int J Cardiovasc Imaging. 2010 Jan;26(1):111-9. [Epub 17 Sep 2009]

59. Dixon S. Detecting Vulnerable Plaque. CathLab Digest. 2009;17(3):10.

60. Sum S, Madden S, Hendricks M, Chartier S, Muller J. Near-infrared spectroscopy for the detection of lipid core

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coronary plaques. Current Cardiovascular Imaging Reports. 2009;2(4):307-315.

61. Maehara A, Mintz GS, Weissman NJ. Advances in intravascular imaging. CircCardiovasc Interv. 2009 Oct;2(5):482-90.

62. Maini B. Clinical Coronary Chemograms and Lipid Core Containing Coronary Plaques. J Am Coll Cardiol Img. 2008;1(5):689-690.

63. Young JJ. Detection of Vulnerable Coronary Artery Plaques Lesion Level Risk Assessment Within the Coronary Arterial Tree? J Am Coll Cardiol Img.2008;1(5):649-651.

64. Muller JE, Dixon SR. Googling the Coronary: Fiberoptics and a Computer Provide the Answers. J Am Coll Cardiol Img. 2008;1:762-764.

65. Waxman S. Near-Infrared Spectroscopy for Plaque Characterization. J Interv Cardiol. 2008;21(6):452-458.

66. Cheruvu PK, Moreno PR, Marshik BJ, Muller JE. Diffuse reflectance near-infrared spectroscopy as a clinical technique to detect high-risk atherosclerotic plaques. In: Waksman R, Serruys PW, Schaar J, eds. The Vulnerable Plaque. 2nd ed. Informa Health Care; 2007:199-210.

67. Urbas AA, Lodder RA. Near-Infrared Spectrometry in Cardiovascular Disease. In: Handbook of Near-Infrared Analysis. 2007.

68. Moreno PR, Marshik B, Muller JE. Near-Infrared Spectroscopy. In: Virmani R, Narula J, Leon M, Willerson J, eds. The Vulnerable Atherosclerotic Plaque: Strategies for Diagnosis and Management. Malden, MA: Blackwell Futura; 2007:257-262.

69. Muller JE, Moreno PR, Cheruvu PK. Definition and Terminology of the Vulnerable Plaque. In: The Vulnerable Plaque. 2nd ed. Informa Health Care; 2007:3-12.

70. Waxman S, Ishibashi F, Caplan JD. Rationale and use of near-infrared spectroscopy for detection of lipid-rich and vulnerable plaques. J Nucl Cardiol. 2007;14(5):719-728.

71. Levin S. InfraReDx: Saved by Angels (and a VC). In Vivo: The Business and Medicine Report. 2006;24(4):1-8.

72. Caplan JD, Waxman S, Nesto RW, Muller JE. Near-Infrared Spectroscopy for the Detection of Vulnerable Coronary Artery Plaques. J Am Coll Cardiol. 2006;47(Suppl_C):C92-C96.

73. Waxman S, Ishibashi F, Muller JE. Detection and Treatment of Vulnerable Plaques and Vulnerable Patients: Novel Approaches to Prevention of Coronary Events. Circulation. 2006;114(22):2390-2411.

74. Muller JE, Tawakol A, Kathiresan S, Narula J. New Opportunities for Identification and Reduction of

Coronary Risk Treatment of Vulnerable Patients, Arteries, and Plaques. J Am Coll Cardiol. 2006;47(8 Suppl C):2-6.

75. Purushothaman KR, Sanz J, Zias E, Fuster V, Moreno PR. Atherosclerosis Neovascularization and Imaging. Curr Mol Med. 2006;6(5):549-556.

76. Muller JE, Moreno PR. Definition of the Vulnerable Plaque. In: Waksman R, Serruys PW, eds. Handbook of the Vulnerable Plaque. Boca Raton, FL: Taylor & Francis; 2004:1-13.

77. Moreno PR, Marshik B, Muller JE. Diffuse Reflectance Near-Infrared Spectroscopy as a Clinical Technique to Detect High-Risk Atherosclerotic Plaques. In: Waksman R, Serruys PW, eds. Handbook of the Vulnerable Plaque. Boca Raton, FL: Taylor & Francis; 2004:205-218.

78. Naghavi M, Libby P, Falk E, et al. From Vulnerable Plaque to Vulnerable Patient: A Call for New Definitions and Risk Assessment Strategies: Part I. Circulation. 2003;108(14):1664-1672.

79. Moreno PR, Muller JE. Identification of high-risk atherosclerotic plaques: a survey of spectroscopic methods. Curr Opin Cardiol. 2002;17(6):638-647.

80. Dempsey RJ, Davis DG, Buice RG, Lodder RA. Biological and Medical Applications of Near-Infrared Spectrometry. Appl Spectrosc. 1996;50:18A-34A.

Current Abstracts

1. Kopřiva K, Mates M, Aschermann O, et al. Utilization of near - infrared spectroscopy (NIRS) in diagnostic coronary atherosclerosis. Paper presented at: Annual Congress of the Czech Society of Cardiology;May 4-7, 2014. Brno, Czech Republic.

2. Madder R, Husaini M, Harnek J, et al. Comparative Lipid Burden of Culprit Lesions According to the Clinical Presentation of Acute Coronary Syndrome. J Am Coll Cardiol. 2014; 63(12_S):A1767.

3. Souza C, Dohi T, Maehara A, et al. Factors Associated with a Reduction of Lipid Core Plaque in Patients Undergoing PCI: Near-Infrared Spectroscopy Results from the COLOR Registry. J Am Coll Cardiol. 2014; 63(12_S):A1769.

4. Souza C, Weisz G, Dohi T, et al. The Use of Near-Infrared Spectroscopy to Identify Patients at High-Risk for Peri-procedural Myocardial Infarction: Results from the COLOR Registry. J Am Coll Cardiol. 2014; 63(12_S):A1770.

5. Smith JL, Zacharias S, Hanson I, et al. Pathology of Femoro-popliteal Atherosclerosis: No Role of Lipid Core? J Am Coll Cardiol. 2014; 63(12_S):A1778.

6. Matsuo K, Ueda Y. Vulnerable Plaques with Intensive Yellow Color by Angioscopy Had High Lipid Core

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Burden Index Measured by Near-infrared Spectroscopy. J Am Coll Cardiol. 2014; 63(12_S):A1786.

7. Qiu F, Maehara A, Kini A, et al. Relationship Between the Extent of Lipid-Rich Plaque Assessed by Near-Infrared Spectroscopy and Clinical Presentation: A COLOR Registry Analysis. J Am Coll Cardiol. 2014;63(12_S):A1788.

8. Zheng B, Maehara A, Mintz G, et al. The Comparison Between Cardiac Allograft Vasculopathy and Atherosclerosis Detected by Near-Infrared Spectroscopy. J Am Coll Cardiol. 2014; 63(12_S):A1801.

9. Zheng B, Maehara A, Mintz G, et al. New Insights in Cardiac Allograft Vasculopathy by Near-infrared Spectroscopy. J Am Coll Cardiol. 2014; 63(12_S):A1673.

10. Madder R, Abbas A, Safian R. First-in-Man Use of Intravascular Near-infrared Spectroscopy in the Carotid Arteries to Characterize Atherosclerotic Plaque Prior to Carotid Stenting. J Am Coll Cardiol. 2014; 63(12_S):A1831.

11. Turfe Z, Husaini M, Chi M, et al. Detection by Intracoronary Near-Infrared Spectroscopy of Lipid Core Plaque at Culprit Sites in Survivors of Cardiac Arrest. J Am Coll Cardiol Intv. 2014;7(2-S):S41-S42.

12. Oemrawsingh RM, Garcia-Garcia HM, Cheng JM, et al. Segmental Analysis of Near-infrared spectroscopy and cardiovascular outcome in patients with coronary artery disease. Circulation. 2013;128:A14764.

13. Madder RD, Muller JE, Puri R, et al. Multicenter Validation of a Near-infrared Spectroscopic Signature of Culprit Lesions Causing ST-segment Elevation Myocardial Infarction: The NIRSTEMI II Study. (TCT-660) J Am Coll Cardiol. 2013: 62(18): B201.

14. Madder RD, Husaini M, Harnek J, et al. An Intracoronary Near-infrared Spectroscopy Signature of Culprit Lesions in Non ST-Segment Elevation Myocardial Infarction. (TCT-653) J Am Coll Cardiol. 2013: 62(18): B198-199.

15. Dohi T, Weisz G, Powers ER, et al. The Extent of Lipid-Rich Plaque Assessed by Near-infrared Spectroscopy May Predict DES Failure: A COLOR Registry Analysis. (TCT-583) J Am Coll Cardiol. 2013: 62(18): B176-177.

16. Erlinge D, Harnek J, Goncalves I, Gotberg M, Muller JE, Madder RD. Coronary Liposuction During Primary Percutaneous Coronary Intervention: Evidence by Near-Infrared Spectroscopy that Aspiration Reduces Lipid Core Size Prior to Stent Placement. (TCT-577) J Am Coll Cardiol. 2013: 62(18): B175-176.

17. Oemrawsingh RM, Cheng JM, Garcia-Garcia HM, et al. Near-infrared spectroscopy predicts cardiovascular outcome in patients with coronary artery disease. Eur Heart J 2013: 34 (suppl 1); (320 ESC 2013 P1619).

18. Hildebrandt H, Kahlert P, Konorza T, et el. Visualization of plaque vulnerability and periinterventional coronary microembolization using near-infrared spectroscopy and optical coherence tomography. Eur Heart J 2013: 34 (suppl 1); (703 ESC 2013 P3925).

19. Andrews J, Puri R, Madden S, et al. The Relationship Between Coronary Arterial Plaque Burden and Lipid Pools: Histological Validation Using Near-Infrared Spectroscopy and Intravascular Ultrasound. (CSANZ 2013) Heart, Lung and Circulation 2013: 22 (S51).

20. Erlinge D, Muller JE, Puri R et al. Validation of a Near-infrared Spectroscopic Signature of Lipid Located at Culprit Lesions in ST-segment Elevation Myocardial Infarction. Presented 1637 at: Annual Meeting of European Atherosclerosis Society Congress; June 4, 2013; Lyon, France.

21. Yallapragada, S. New Frontiers in Intravascular Imaging: A Case Presentation of Near Infrared Spectroscopy. Paper presented at: Complex Cardiovascular Catheter Therapeutics; June 17, 2013; Orlando, Florida.

22. Madder R, Muller J, Puri R, et al. International Prospective Validation of an Intracoronary Near-Infrared Spectroscopy Signature of Culprit Lesions in Acute STEMI. J Am Coll Cardiol. 2013:61(10-S): E1848.

23. Yonetsu T, Suh W, Abtahian F, et al. Comparison of Near-Infrared Spectroscopy and Optical Coherence Tomography for Detection of Lipid. J Am Coll Cardiol. 2013:61(10-S): E1796.

24. Fuh E, Hester A, Patel V, et al. Saphenous Vein Graft Body Lesions Have Higher Lipid Content Compared to Anastomotic Lesions: A Near-Infrared Spectroscopy In Vivo Study. J Am Coll Cardiol. 2013:61(10-S): E1850.

25. Madden S, Raichlen J, Muller J. Spectroscopic Detection of Fibrous Cap Thickness Overlying Lipid Core Coronary Plaques with a Catheter-Based Near-Infrared Spectroscopy System. J Am Coll Cardiol. 2012:59(13s1):E308.

26. Kini A. Moreno P, Kovacic J, et al. Does Aggressive Statin Therapy Reduce Coronary Atherosclerotic PlaqueLipid Content? Results From: Reduction in YEllow Plaque by Aggressive Lipid LOWering Therapy (YELLOW) Trial. J Am Coll Cardiol. 2012:59(13s1):E304.

27. Smith J, Madder R, Bilolikar A, LaFleur J, Goldstein J. Incidence and Morphologic Characteristics of Plaques that Evolve into Culprit Lesions: A Coronary CT Angiography Natural History Study. (TCT-313) J Am Coll Cardiol. 2012: 60(17): B88).

28. Madder R, Wohns D, McNamara R, et al. Frequency of Spotty Calcification Among Lipid-Core Plaques Using Combined Intracoronary Near-infrared Spectroscopy and

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Intravascular Ultrasound. (TCT-266) J Am Coll Cardiol.2012.60(17):B76.

29. Smith JL, Madder R, Bilolikar AN, Dixon S, Goldstein J. Coronary Computed Tomographic Angiography Morphologic Characteristics of Lipid Core Plaques Identified By Intracoronary Near-Infrared Spectroscopy. (ACC-2012) J Am Coll Cardiol. 2012:59(13sl):E307

30. Brilakis E. Distal Embolization during PCI: Predicting Distal Embolization Using Grayscale IVUS, IVUS, RF-IVUS, OCT, and NIRS. i2 abstract 2639-10. ACC 2012.

31. Heo JH, Brugaletta S, Garcia-Garcia HM, De et al. Distribution of Lipid Core Rich Plaques in Coronary Bifurcations Assessed by Near-Infrared Spectroscopy. J Am Coll Cardiol. 2012:59(13s1):E1431.

32. Madden S, Raichlen J. Muller J. Detection of Thin and Thick Fibrous Caps Overlying Lipid Core Coronary Plaques with a Catheter-Based Near-Infrared Spectroscopy System. J Am Coll Cardiol. 2012;60(17-S).

33. Puri R, Madden S, Muller J, et al. Combined Near-Infrared Spectroscopic and Intravascular Ultrasound Assessment Of Coronary Plaque Burden and Lipid Pools: Validation With Histology. J Am Coll Cardiol. 2012;60(17-S).

34. Maini BS, Kini A, Virmani R, Sharma S, Narula J. In vivo Lipid Core Plaque and Spatial Distribution in Patients with Unstable Angina and NQMI: A Near-Infrared Spectroscopy Study. J Am Coll Cardiol. 2012;59(13s1):E140.

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