Information Landscape KB

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Mercks Information Landscape

Knowledgebase

Kelly Clark & Charisma EugenioJune 10, 2014


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ModelingMercksInformationLandscape

(MRL

=

Merck

Research

Laboratories)

Metabolomics

Geneexpression

Sequencing

Pharmacogenetics

Imaging

Safety/PV Realworlddata

Clinicaltrials

GlobalEMRs&registries Socialnetworks/patientcommunities

MonitoringBehavior/adherence/compliance

Vaccineproduction

RNAi

HTS

PathwaysBiologicallit./Targets

Chemistry/Chemicallit

Disease

Competitiveintelligence

Pharmacology

Epidemiology

TargetClass

MechanismofAction

Toxicity

Outcomes

EHR

Stagegatedecisions

Externalpartners

Indication

Targetedinstitutions

Engagementprograms

Formulary

Marketaccess/channels

Batchrecords

Labeling

QualityAssurance

Manufacturing&processdesign

2011 Retina Diagram - Concept


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InformationTypes/TaxonomiesfromMercks

InformationLandscape

Knowledgebase

(ILK)

3

Marketing

Regulatory

Clinical

Molecules/

Compounds

PharmacologyToxicology

PK/PD

Studies

Gene

Competitive

Intelligence

Animals

Biological

Specimens

Assays

RealWorld

Evidence

Targets

ProteinExperimentsLaboratory

Programs

Biomarkers

Modeling&

Simulation

2014 Retina Diagram - Real

This graphic created using Gephi: Bastian M., Heymann S., Jacomy M. (2009). Gephi: an open source software

for exploring and manipulating networks. International AAAI Conference on Weblogs and Social Media.


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R&Ddecisionsrelyonhighqualityinformationtosteer

programsandthepipeline

Knowledge

Artifacts

Target

validation

plan

BusinessGroups

Early

Development

team

People

John

Smith

InformationTypes

Clinical

Trial

Name

OrganizationUnits

Analytical

Chemistry

Sources

Electronic

Lab

Notebook

Business

ProcessesIntegrative

assessment

of

liver

toxicity Activities

Refine

model

Roles

Statistician

Decisions/

Gateways

Determine

Patient

Stratification

Biomarkers

R&DInformationLandscape>27,000

entities

and

70,000

relationships

defined

The

volume

and

variety

of

internal

information

and

external

scientific

information

continues

to

grow

at

a

rapid

and

accelerating

rate

The

ability

to

readily

find,

access,

and

useinformation

is

absolutely

critical

Capabilities

Biomarker

Validation

Feedback

Surveys,

VoC


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5

Today Next 2-3 Years Beyond

Culture of Single Use

Find & Access

DecisionMaking

Quality

Vocabulary

Management

Embedded

Stewardship

Information

Flows Modeled

Effective

Search

Integrated

Information

Architecture

IM Challenges

Characterized

Fragmented

tools,

processes

Systematic

categorization

of data

Information

ManagementMatu

rity

As knowledge workers understand and embrace improved information management

practices, better decision making can be enabled by better access to information

Organization-Wide Information Re-Use

? Better Information Management Better Decision Making: Betteranalysis, more transparency and collaboration, better workflow

management, faster decisionsDecisionQuality

Adop

tion,

Maturity

ImprovingR&DDecisionMaking

Information

Flows Modeled


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Clinical

Development

ConsumerCare

Research

FormulationSafety

Regulatory

Manufacturing

EnterpriseBusinessAnalysisandITResourceplanning

tendstofocusonorganizationaldomainsseparately

Every system is perfectly designed to get

exactly the results it gets. --


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GoogleStreetViewforinformationflows


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Merck

Analystsneedawaytocollaborateon mappinginformationflows

fromdifferentdomainswithoutexplicitcoordination

http://www.dwalls.com/Nature/Nature-World-Travel/Aerial+View+of+Downtown+Boston


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Isamethodofdocumentingandmodelingtheflowofinformationthroughanenterprise

thatallowsbothtargetedandholisticanalysisacrosstheinformationcontinuum.

Sales&

Marketing

MCC

Regulatory

R&D

ManufacturingMerck

SemanticInformationFlowModeling(sIFM)

Regulatory


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DiscoveringtheInformationFlowModeling

Ontology

MindMapforMercksPatientsLikeMecollaborationhanddrawnbyJyotiShah

Usedwith

permission

from

PatientsLikeMe


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DataSources

Organizations BusinessProcesses

Decisions

KM

Artifacts

Initiatives

/ Projects

Use

CasesPeople Roles

Information

Types CapabilitiesBusiness

GroupsActivities

Wedeterminedthetypesofthings(entities)andthetypesofrelationships

thatweweretryingtounderstandandmodelthemusingacommon

semanticframework


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CollaborationwithoutCoordination

Theuseofaninformationmodelingontology allowsmultipleinformaticsand

businessanalyststocollaborateonthesamemodelwithoutexplicitcoordination

Analyst 1 Analyst 2 Analyst 3

Compound structure ELN Medicinal Chemist uses ChemCart Pharm Sci uses ELN

Program Biologist uses ELN Compound Structure ChemCart Active Pharmaceutical Ingredient ELN

Toxicologist uses ELN Medicinal Chemist member-of Lead

optimization team

Compound StructureELN


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LeveragingtheInformationLandscape Knowledgebase

toenableInformationManagementandSearch

By encoding this knowledge in a searchable semantic knowledgebase, we can discover details

about Mercks information landscape on the fly, that were previously difficult to uncover.

Project Information

Types

Data

Sources

KM

Artifacts

Translational

PK/PD Modeling ?Information

Types

?KM

Artifacts

?Data

Sources

includes

flow

flow

What are the types

of information and

data sourcesassociated with

Translational PKPD

Modeling?


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InformationLandscapeKnowledgebase(ILK)


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InformationLandscapeKnowledgebase

Entity

Explorer

for

Ad

Hoc

Analysis

Joe Smith

Jane Doe


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InformationLandscapeKnowledgebase

Data

Sources


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Drilldownbyfacetingonanyentitytype

18


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Feedback/PainPointAnalysis

19

MRL Search Survey 2013

Example Pain Point Categories:

Access provisioning

Business Process/Workflow

management

Data Quality and Completeness

Data Security

Data Vizualzation/Analysis

Capabilities

Federated Search

Knowledge Management and

organization

Platform / Database

Tags / Keywords

Training / Awareness


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Summary MercksInformationLandscape

Knowledgebase Volume and complexity of scientific information is accelerating

It is critical that scientists can seamlessly find and access that

information

Traditional analysis makes it difficult to understand how information is

actually stewarded across the organization, and perpetuates the

establishment of siloed solutions

Semantic Information Flow Modeling and the Information Landscape

Knowledgebase allows analysts and architects to collaborate on a

common representation of information flow across the organization to

enable:

Linked-data approach to analysis

Identification of high impact scientific information management solutions

Stewardship of Mercks knowledge assets

20


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Acknowledgements

Merck Research Laboratories Information Technology

Karen Conrad

Charisma Eugenio

John Koch

Ellie Norris

Jyoti Shah

Kim Wilson

Cambridge Semantics Inc.

Ben Szekely

Lee Feigenbaum

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Mercks Information LandscapeKnowledgebase

Charisma EugenioJune 10, 2014


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Anzo Express is a complete spreadsheet data management solution. It enables

users to link data from multiple Excel spreadsheets and relational databases

together in real-time for data collection, collaboration, and reporting. Anzo Express

also includes a state-of-the-art Web dashboard tool so that you can easily share

your integrated Excel data with your colleagues.

Anzo Ontology Editor

Anzo Connect

Anzo for Excel

Anzo on the Web

Anzo Express


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Information Flow Model (IFM)


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IFM Oracle Database Schema


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Anzo Connect


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Anzo Connect


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Anzo Connect


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Anzo Connect


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Anzo Connect


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Anzo Connect


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Information Landscape Knowledgebase (ILK)


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ILK Entity Explorer


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ILK Entity Explorer


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ILK Entity Explorer


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ILK Entity Explorer


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ILK Entity Explorer


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ILK Entity Explorer


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ILK Entity Explorer

ILK E tit E l


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ILK Entity Explorer

ILK S t


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ILK Systems

ILK S t


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ILK Systems

ILK Systems


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ILK Systems

ILK Systems


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ILK Systems

ILK Systems


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ILK Systems

ILK Systems


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ILK Systems

ILK Systems


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ILK Systems

ILK Systems


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ILK Systems

ILK Systems


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ILK Systems

ILK Systems


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ILK Systems

ILK Systems


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y

ILK Systems


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ILK Systems


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ILK Systems


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ILK Systems


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ILK Systems


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Documents

Information Landscape KB