Kinase Phosphatase Ligand Transcription Factor Other Receptor Phospho Activation

Membrane Cell Function Binding/Association

Activation Inhibition Indirect Effect Dissociation

P

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p-CREB-1 GSK3 alpha p-JNK123 (Thr183 + 185) p-c-Fos p-STAT3 tyr705

IF | Rat brain IHC-P | Rat brain WB | Mouse brain IHC-P | Mouse osteosarcoma FCM | Human melanoma

P P P P P P P PP

TRAF6

RAC

MKP

HSP27

MKP

Stress Response

P

Growth, development, proliferation Inflammation, apoptosis, differentiation, proliferation

JNK 1/2/3

Cell Membrane

Growth Factors

RTK

Shc Grb2 SOS RasSRC

αγ

β

Raf B-RafA-Raf

MEK1/2

ERK1/2

DAPK

RSK

GSK3

IKBα

p38

Bim

MEK4/7

MAP3K4/12

ASK1 TAK1

IRAK1

IRAK4

MK2

β-arrestin

MEK3/6

c-FOS STAT ELK c-JUN c-JUN CREB ATF2 SP-1 c-MYC

P

P

P

P

P P P

P

P

P

P

P

P

P

P

Activated GPCR

Stress (UV irradiation)Inflammatory cytokines

P

B I O S S P AT H W AY S

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