Necrosis

Microorganisms

Physical and chemical agents

Hypersensitivity

Duration - acute, chronic

Distribution- focal, diffuse

Exudate- serous, purulent, fibrinous

Tissue name - hepatitis, myocarditis

Peracute acute subacute chronic

Serous

Catarrhal

Fibrinous

Hemorrhagic

Purulent

Necrotizing

Granulomatous

Horse

Acute focally extensive necrotizing stomatitis

Cow

Focal purulent encephalitis (also cerebral abscess)

Cow

Chronic proliferative pericarditis

Dog

Acute diffuse fibrinous enteritis

Goat

Diffuse hemorrhagic cystitis

Vascular changes

Vessels dilate and become leaky

Leukocytes and endothelium “talk” to each other

Leukocytes in axial flow

Normal axial flow

Margination

Margination

Rolling

Adhesion

Leukocyte integrins interact

with the ICAMS and VCAMS

Firm adhesion

Emigration Emigration

NEUTROPHILS

Eosinophils

Macrophages

purulent paronychia

Duration - acute, chronic

Distribution- focal, diffuse

Exudate- serous, purulent, fibrinous

Tissue name - hepatitis, myocarditis

Type I

Type II

Type III

Type IV

icterus

Vesicular dermatitis

Vascular components much less pronounced

Hallmark is MACROPHAGES

Usually some fibrous tissue

Chronic ulcerative dermatitis

Bone – a system all its own

Heart, Brain – doesn’t happen!