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Inexpensive and Accessible Thermal
Imaging for the Detection of Cancer
INFRANOSTICS
Angela FanBen WangMark BucklinNancy DiaoOlufunke Laseinde
A Device That Will:
Measure Skin-Surface Temperature
Report Topographic Location
Be Inexpensive
Software That Will:
Map and Record Spatial Temperature Fluctuations
Recognize Patterns of Carcinoma Development
A Problem and a SolutionMethods Used to
Screen and Monitor for Cancer
Current Methods
Expensive
Uncomfortable
Inconvenient
Rely on Presence of Tumor not Growth of Tumor
Detecting Cancer: Current MethodsCommon
Mammography
Self Exam
Ultrasound
Less Common
MRI
PET/CT
Thermography
From top left, clockwise: Mammogram (Harvey), Breast Self Exam, Ultrasound of the breast (Tiefenbacher), MRI of the breast with T1 contrast and fat reduction (Harvery), Combined PET and CT (Lavayssiere), Breast Thermogram (http://www.aathermography.com)
Thermography “Breast thermography has an average sensitivity and specificity of 90%”
“Breast thermography has the ability to detect the first signs that a cancer may be forming up to 10 years before any other procedure can detect it.”
“When used as part of a multimodal approach (clinical examination + mammography + thermography) 95% of early stage cancers will be detected.”
Bronzino, Joseph. The Biomedical Engineering Handbook. 3rd ed. ©2006. CRC Press. Ch.25
CMOS Focal Plane Array Cameras
~10 μm IR radiation at 36º C
FDA Approved for Screening Alongside
Mammograms
Particularly good at screening for•Breast Cancer•Pain•Neurological Disorders
Top to Bottom: Angiogenesis (http://www.gene.com/gene/research/focusareas/oncology/angiogenesis.html), Breast Thermogram (http://www.thermogramcenter.com/Images.htm)
Similar DevicesThermal Imaging CameraHandheld Optical Scanner
• Near Infrared Absorbance
• Drexel/Upenn• In Clinical Trials
Single-Sensor Thermography System
Left: Material from Drexel/Upenn device by Chance, B (http://www.biomed.drexel.edu/new04/Content/ProgressReport/fnir_breastcancer.pdf) , Center: Nec TS9100 Thermal Imaging Camera (www.metrum.co.uk) , Thermal Body Scan (http://thermalbodyscan.com/DITI.aspx). Right: Se Jin Yoon, et. Al. A Study of Thermographic Diagnosis System and Imaging Algorithmby Distributed Thermal Data using Single Infrared Sensor. Conf Proc IEEE Eng Med Biol Soc. 2007;2007:3319-22.
Design Specifications/Constraints
DesignSpecifications/
Constraints
Power-Enough power to run a complete body scan
Accessible/Inexpensive-Lightweight & Handheld-Home-Family Physician,-Humanitarian
Software-User Friendly GUI-Pattern Recognition
Versatile-Comfortable and Adaptable
Reliable-At least 95% accuracy-Detect temperature changes of ~0.1˚F
Spatially Accurate-Develop Anatomically Relevant Temperature Map
Thermopile
Components and Related Products
Gyro
Accelerometer
Optical Sensor
Optical Sensor Thermistor
Position Tracking Temperature Measurement
Design Concept #1
CPU•Process position•Display Coverage•Store Temperature•Give Directions•Diagnose via Pattern Recognition
Handheld Device•Thermopiles•Optoelectronic Sensors•Gyro/Accelerometer•IR Tracker
User
Designed with help from: http://gfx-3d-model.blogspot.com/2008/06/laptop-01.html http://www.linkwitzlab.com/Pluto/w-asp-pcb.jpg
Design Concept #2
Advantages• Form-fitting, stationary
devices allows the surveyed area to be easily mapped
• User will be familiar with and the device form
• Material will be comfortable.
Disadvantages• Needs to be made for a
variety of breast sizes.
Designed with help from: http://gfx-3d-model.blogspot.com/2008/06/laptop-01.html http://www.linkwitzlab.com/Pluto/w-asp-pcb.jpg
Design Concept #3
Advantages• No complex tracking
needed since device would be stationary
• Flexible material is suitable for a range of breast sizes
Disadvantages• May be large, and
unwieldy• May be uncomfortable
Questions?
