Indoor Air Pollution, Environmental Tobacco Smoking, and Lung Cancer Zuo-Feng Zhang, MD, PhD...
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Indoor Air Pollution, Environmental Tobacco Smoking, and Lung Cancer Zuo-Feng Zhang, MD, PhD Professor, Department of Epidemiology UCLA School of Public
Indoor Air Pollution, Environmental Tobacco Smoking, and Lung
Cancer Zuo-Feng Zhang, MD, PhD Professor, Department of
Epidemiology UCLA School of Public Health UCLA Center for
Environmental Genomics The 5th International Conference on
Environmental and Occupational Medicine Dujiangyan, Chengdu,
Sichuan, P.R. China April 7-10, 2010
Age-standardized Incidence Rates For Lung Cancer Source: Figure
5: Parkin DM, et al. CA Cancer J Clin [2005]; 55: 74-108
Slide 7
Risk Factors for Lung Cancer Tobacco smoking Second hand
smoking (passive smoking) Asbestos Radon exposure Occupational
exposures Air pollution Other radiation Recurring inflammation
Family history of cancer Insufficient diet and poor nutritional
factors
Slide 8
Fuzhou, Air Pollution and DNA Repair Genes and Lung Cancer: 600
cases and 600 controls Taiyuan, Air Pollution and Lung Cancer: 400
cases/ 400 controls China-UCLA Lung Cancer Consortium Jiangsu:
Epidemiolo gy of Top 4 Cancers (Lung, esophagus, liver and
stomach)
Slide 9
Specific Aims of the China-UCLA Lung Cancer Consortium To
identify novel environmental risk and protective factors To
evaluate genetic susceptibility To assess potential
environment-gene interactions
Slide 10
Indoor Air Pollution in China, Preliminary Results
Slide 11
TaiYuan Project Cases: 396 newly diagnosed patients with lung
cancer from major cancer hospitals in this city between 2006-2007;
Control: 465 healthy control from the same source population;
Epidemiological data were collected by in-person interview using a
standard questionnaire;
Household Second Hand Smoking Exposure and Lung Cancer Risk
among Non-smokers RelationshipETSCaseControlAOR&95%CI No71129
AnyYes106 (60)155(54.6)1.18 (0.80-1.74)
SpouseYes91(51)102(35.9)1.53 (1.00-2.34) Only othersYes15530.53
(0.28-1.01) Spouse + othersYes17300.94 (0.48-1.84)