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Indiana Institute For Personalized Medicine
David A Flockhart MD, PhDDavid A Flockhart MD, PhD
Professor of Medicine, Genetics and Pharmacology Professor of Medicine, Genetics and Pharmacology
Indiana University Indiana University
Challenges for Personalized Medicineas a Health Care Solution
Genomics has not deliveredGenomics has not delivered Proteomics has not deliveredProteomics has not delivered Bioinformatics has not deliveredBioinformatics has not delivered Small and Dry Pharmaceutical PipelinesSmall and Dry Pharmaceutical Pipelines Effective Electronic Medical Records are Rare Effective Electronic Medical Records are Rare
EventsEvents
•.
F S Collins Science 2011;331:546-546
It’s Been Ten Years
•“the once-hypothetical medical benefits of individual genome sequencing are
beginning to be realized in the clinic.”
•F S Collins Science 2011;331:546-546
•….in fact, it's one of the many reasons that NIH plans to create a National Center
for Advancing Translational and Therapeutic Sciences
““If I could move the clock back to 2001 and change If I could move the clock back to 2001 and change course, I would invest significantly more in course, I would invest significantly more in developing large clinical resources with detailed, developing large clinical resources with detailed, individual clinical histories, deep phenotyping, individual clinical histories, deep phenotyping, and longitudinal follow-up in order to better and longitudinal follow-up in order to better understand outcomes and treatment responses”understand outcomes and treatment responses”
•Tom Hudson, Science 2011;331:547
The Genome Wide Association barrier : 282 Genome Wide Association StudiesPublished in Peer-Reviewed Journals since January 2007
Genome Wide Association as a tool for predictive medicine
•Fletcher R, Flockhart DA, 2010
Genome-wide association study identifies 6 novel breast cancer susceptibility loci
Nature May 27th, 2007
•1.27 fold = the risk conferred by 1 glass of wine per day
Tools for Personalized Medicine in Indiana A Robust Electronic Medical Record with Long Follow UpA Robust Electronic Medical Record with Long Follow Up A Biobank of Samples that Links to the EMRA Biobank of Samples that Links to the EMR Genomic and Pharmacogenomics ExpertiseGenomic and Pharmacogenomics Expertise Imaging ExpertiseImaging Expertise Informatic ExpertiseInformatic Expertise
Center for Computational BiologyCenter for Computational Biology
Modeling ExpertiseModeling Expertise CTSI Disease and Therapeutics Modeling ProgramCTSI Disease and Therapeutics Modeling Program
Trained ProfessionalsTrained Professionals Strategic Partnerships with ImplementersStrategic Partnerships with Implementers
Implementers of Personalized Medicine
PatientsPatients PhysiciansPhysicians PharmacistsPharmacists NursesNurses Diagnostic CompaniesDiagnostic Companies Pharma CompaniesPharma Companies BiotechBiotech
Indiana Institute For Personalized Medicine
Founded January 1Founded January 1stst, 2011, 2011
Schools of Medicine, Nursing and Informatics, IU Schools of Medicine, Nursing and Informatics, IU Cancer Center and the Regenstrief InstituteCancer Center and the Regenstrief Institute
Open to all IU FacultyOpen to all IU Faculty New Brater Fellowships in Personalized MedicineNew Brater Fellowships in Personalized Medicine New Pilot fundingNew Pilot funding New FacultyNew Faculty
Brater Scholar Program
A Mentored Program to Prepare Physician A Mentored Program to Prepare Physician Scientists for Careers in Personalized MedicineScientists for Careers in Personalized Medicine
Emphasis on Peer Collaboration Among FellowsEmphasis on Peer Collaboration Among Fellows Salary supplementSalary supplement $ for supplies and travel$ for supplies and travel
2011 Brater Scholars in Personalized Medicine Troy Quigg MD, Pediatric OncologyTroy Quigg MD, Pediatric Oncology Vic Senadhi MD, Division of GastroenterologyVic Senadhi MD, Division of Gastroenterology Jody Skiles, Department of PediatricsJody Skiles, Department of Pediatrics
Indiana Biobank: Goals To create a statewide, robust collection of biological samples
To be accessible to basic and clinical investigators as a research tool
• To enroll and collect samples from 50,000 patients in 5 years
Established in July 2010
50,000 high quality samples in 5 yearslinked to the electronic medical record
and to genomic and proteomic data.
•Available to basic and clinical researchers.
•Patients from Clarian Health, Wishard and other clinical venues throughout Indiana: a Key Research Arm of the IU Health system
Indiana Biobank: Purpose
Anne Nguyen CCRP
Academic Strategic Partnerships
Department of MedicineDepartment of Medicine Department of PediatricsDepartment of Pediatrics
PREGMEDPREGMED Center for Pediatric Clinical TherapeuticsCenter for Pediatric Clinical Therapeutics
Department of OB/GYNDepartment of OB/GYN IU Cancer CenterIU Cancer Center
Center for Computational BiologyCenter for Computational Biology Department of RadiologyDepartment of Radiology
Regenstrief InstituteRegenstrief Institute
Targeted Areas for Strategic Partnerships
Diagnostics OrganizationsDiagnostics Organizations Therapeutics OrganizationsTherapeutics Organizations
International:International: KenyaKenya ChinaChina
NIHNIH FDAFDA
Indiana Institue For Personalized Medicine Leadership
Lang Li PhDComputational
BiologyBryan Schneider MD
IU Cancer CenterJamie Renbarger MD, MS
Pediatrics
Anne Nguyen CCRPIndiana Biobank