451

Index

A

A-beta-lipoproteinemia 201, 389 abortion 431 acanthocytosis 389 acanthosis 416 accuracy 162 acidic dye 15 ACTH 260, 265 actinomycin 414 actomyosin 106 acetyl choline 15 acute glomerulonephritis 347

nephritis 11 7 phase reactant 78, 112, 129, 257, 261

425 - response condition

Addison's disease, idiopathic adenosine 15 adjuvant disease 269, 280 adrenalin 34, 260, 265 adrenalitis 292

16 292

adrenocorticoid 22, 260, 265, 414 adsorption rate 162 afibrinogenemia 132, 390 agammaglobulinemia 113, 133, 217, 397 -,autosomal recessive alymphocytic 410 -, Bruton's type 394, 398 -,infantile sex-linked 400 -,Swiss type 410

agglutinin 69 -,saline 71

Ag-system 85 albumin 11, 22, 114, 115, 117, 131, 132,

134, 213, 227, 242, 249, 352, 433, 437 -, adult 13, 435

albumin adsorption 163 A 12

- A1 12 - A2 12 - B 12 -, biological characteristics of 14 -, chemical characteristics of 11 -,chemical structure 12 -, clinical abnormalities of 16 -, fetal 13, 435 -,hereditary types of 12 -, immunoelectrophoretic characteristics of

14 -Mexico 12 - Naskapi 12 -, N-F transformation 11 -normal 12

-, physical characteristics of II - rapid 12 -Reading 12 -,serum II -slow 12 -,total circulating 101 -,total exchangeable 101 - turnover 10 I, 227

alcohol intoxication 89, 421 aldosterone 24 A-lipoproteinemia 89 A-lipoprotein 89 alkaline phosphatase 36 alkylating agent 414 allergen 73 allergic disease 260, 279 allergy 290 alloalbumin 377 alloalbuminemia 12, 14 a-chain 29, 65 a chain disease 312, 364 a-fetoprutein 270, 379, 432 a-lipoprotein 79

- deficiency 388 a1-acid glycoprotein 18, 131, 214, 243, 261,

425, 433, 437 -, biological characteristics of 20 -,chemical characteristics 18 -,chemical structure 18 -, clinical abnormalities of 20 -,hereditary types of 19 -,heterogeneity 18 -, immunoelectrophorcticc haracteristics 19 -, physical characteristics of 19

a 1-antitrypsin 20, 27, 75, 78, 214, 243, 261, 433, 437 (see alAT)

-, chemical characteristics 20 -, chemical structure 20 -, deficiency 383 -, hereditary types 21 -, heterogeneity 20 -, immunoelectrophoretic characteristics 21 -, physical characteristics of 20

a 1-easily-precipitable glycoprotein 24 a1-fetoprotein 379 (see a-fetoprotein) a1-glycoprotein 20, 352 -, tryptophan-poor 25

a 1-lipoprotein 84, 131, 214, 243, 433 a 1-trypsin-inhibitor 20 a1-seromucoid 18 alAT• biological characteristics of 21 -, clinical abnormalities 21

a1x-glycoprotein 25 a2-globulin 274

452

az-lipoprotein 79 a 2-macroglobulin 31, 35, 75, 104, 214, 261,

345, 383, 433, 437 -, biological characteristics of 35 -, chemical characteristics of 35 -, chemical structure of 35 -, clinical abnormalities of 36 -, immunoelectrophoretic characteristics of

35 -, immunoelectrophoretic pattern 36 -, physical characteristics 35

a 2-mucoprotein 75 azHs-glycoprotein 37, 261 amethopterin 414 amino acid 3 amino acid pool 98, Ill amnion 438 amniotic fluid 144, 438 --embolism 134

amyloid 365, 366 -kidney 139 -tumor 366

amyloidosis 201, 218, 312, 356, 365 -, intestinal 226 -,local 366 -, primary 366 -,secondary 366

anabolic steroid 134 analbuminemia 116, 133, 260, 380 -,congenital 16

analpha-lipoproteinemia 89, 388 anaphylatoxin 47 anaphylaxis 72 -,local 73 -, passive cutaneous 72, 73

anemia 35, 155, 338, 360 ANF 296 (see antinuclear factor) angioneurotic edema 117 anhaptoglobinemia 384, 385 -,congenital 32

an-immunoglobulinemia 267 (see agammaglo­bulinemia)

-,infantile sex-linked 400 ankylosing spondylitis 347 anthrone 76 anti-albumin activity 324 anti-aorta antibody 295 anti-/1 lipoprotein activity 324 antibiotic 22 antibody 436 antibody, anaphylactic 72 -,complete 71 -, cytophilic 72 -, heterologous anaphylatic 72, 73 -, heterotropic 72 -, homocytotropic 72 -, homologous anaphylactic 72 -,incomplete 71 -, virus-neutralizing 71

anticoagulant 171 -,circulating 276, 277, 292

anticomplementary activity 275, 348 -effect 352

anti-cytomegalovirus 348 antigen-antibody complex 44, 47 antigen-binding fragment 58

INDEX

anti-1 activity 369 anti-liver antibody 244 anti-lymphocyte serum 414 antinuclear antibody 276, 348 antinuclear factor 296 anti-staphylolysin activity 324 anti-streptolysin 0 324, 395, 396 antithrombin 277 antithromboplastin, circulating 292 antitoxin 69, 71 antoimmune disease 260 anxiety 260 aortic arch syndrome 292 (see aortitis synd-

rome) aortitis syndrome 295, 376 aplastic anemia 49 apo-ceruloplasmin 33, 34 apoferritin-ferritin system 42 apolipoprotein 79, 81 -,A 79 -,B 79 -,0 79

apoplexy 356 a porepressor 111 aqueous humor 143 arterial embolism 140 arteriosclerosis 416, 422 arteritis temporalis 292 arthritis 125 Arthus phenomenon 72 ascites 120 -, chylous 223

ascitic puncture 206 ascorbic acid 34 ASO titer 397 aspermatogenesis 292 asthmatic bronchitis 402, 404 atebrine 15 atherosclerosis 416 atopic disease 279 atransferrinemia 216, 386, 387 -,congenital 42

aureomycin 15 autoallergic disease 290 autoantibody 277 autoimmune disease 48, 73, 269, 290, 312,

356, 376 - -,organ-specific 291

autoimmune hemolytic anemia 292, 385, 391 - - -, warm type 372, 373 - - diseases 368

auto-immune process 134 autoimmunity 290 autosensitivity 290 autosensitization 273, 290 autosomal recessive lymphopenia with normal

immunoglobulins 410 auto-toxicosis 260 azathioprine 414

B

bacterial infection 263 bactericidal reaction 4 7 bacteriocidin 395 Bandrowski's complex 34

barbiturate 15, 17 - intoxication 54

Beh~et's disease 296, 300 Bence .Jones protein 136, 312, 331, 333, 352,

357, 365, 367, - - proteinemia 333, 335, 338 - - proteinuria 366

benzidine staining 31 berylliosis 280 li-chain 29 li-y bridging 236 (sec li-y linking) li-y linking 236, 238, 239, 244, 251 li-lipoprotein 79, 115, 383, 437 lit.-metal combining globulin 38 lirA-globulin 45, 75 lilA -globulin, immunoelectrophoretic patterns

of 45 1i1c-globulin 44, 75, 134, 217, 247, 311, 433,

437 lite-globulin, immunoelectrophoretic patterns

of 45 li Ic/A -globulin 44, liic-lilA conversion litc-li1c conversion litE-globulin 46 liiF-globulin 47 Btc-globulin 45

105, 261 45 45

li2 fraction 127, 128 1i2-glycoprotein 49, 75 1i2A-globulin 64 1i25-glycoprotein 49 s,6-9(li) lipoprotein 131 BFP 275 (see biological false positivity) bile 135, 142

acid deficiency 201 canaliculi 247 pigment 22

biliary cirrhosis 422 bilirubin 15 biological half-life 131 bisalbuminemia 12 blast cell I 06 bleeding 54, 206, 232 -, internal 44 - tendency 155

blind loop 20 I blood coagulation disorder 352

- - factor 352 blood-brain barrier liS blocking antibody 69 burn 1 17, 226, 228, 230, 257 busulfan 4 1 4 bone marrow 115 bradykinin 52 Brahmachari-Senn test 345 brain tumors 130 brain-blood barrier 126 5-bromdeoxyuridine 414 bronchial asthma 402 bronchiectasis 231 bronchitis 296 bronchopulmonary mucosa 73 Bruton's disease 400

INDEX

c

cachexia 20, 21, 78, Ill, 201, 266 cadmium poisoning 141 calcinosis hyperglobulinaemica 301 cancer-specific protein 379 cantharidin 228 - vesicle II 7

capillary filtration I 16 - permeability 116 - pressure 116

carbazole 76 carbohydrate, protein-bound 74 carcinoembryonic antigen 379 carcinoid 8 7

- syndrome 201 carcinoma 49, 201, 356, 366 - of pancreas 201 - of the urinary blandder 239

cardiac failure 117, 260 cardiolipin 275 cardiomegaly, familial 226 carpal-tunnel syndrome 365 catabolic rate I 31 - -,absolute 131 - -,fractional 131

catabolism, endogenous 132 catechol 34 catecholamine 22 celiac disease 201. 226 cell-mediated immune reaction 72 cell, ultrastructure of the lOS cellular antibody 69 cellulose acetate membrane 159 central nervous system I I 5 - - -,degenerative disease of the 130

cere bra! apoplexy 129 - arteriosclerosis 199

cerebrospinal fluid 125 ceroid 389

453

ceruloplasmin 32, 35, 75, 77, 104, 261, 424, 433. 437

-, biologic~! characteristics of 34 -. chemical characteristics of 32 -: chemical structure of 33 -,clinical abnormalities of 35 -,immunoelectrophoretic characteristics of

-,oxidase activity of 34 -,physical characteristics of 32 - deficiency 384

cervical secretion I 43 chelating compound 33 chemotaxis 4 7 chlorination 81 chloromycetin 15 cholesterol 82 -,free 87 -,total 87 - ester 82, 87

cholesterosis 416 cholinesterase 15, 36, 75, 78 chorionic gonadotropin 75, 78 choroid plexus 126 chromatography 6

33

454

chronic infection 345 - infectious disease 260

chylomicron 79, 81, 88, 104, 165, 147 -,a- 82 -, {J- 82

chylous ascites 226 - fistula 226

chyluria 141, 206, 233 circulatory shock 226 cirrhosis, alcoholic 247, 250 -,biliary 247, 252, -, cardiac 24 7 -,fatty 247 -,metabolic 247 -,nutritional 247 -,parasitic 247 -, posthepatitic 247 -, postnecrotic 247 -, primary 24 7 -,syphilitic 247

Cl esterase 47 - - inhibitor 388

clinical syndrome 405 coefficient of variation 162 cold agglutinin disease 307 - hemagglutinin 327, 348, 369 - hemagglutin disease 369 - hemagglutinin syndrome 292, 312,

colitis cystica profunda 226 collagen disease 296 colloidal osmotic pressure 16, 215 colon 145 colostrum 143, 144, 439 coma paraproteinemicum 340 corrunon bile duct, cyst of the 255 complement 44, 71, 75, 104, 265, 352 -,bacteriolytic reaction of 47 -, biological characteristics of the - system

47 -, clinical abnormalities of 48 -,cytolytic reaction of 47 -,hemolytic reaction 47 -, physicochemical characteristics of the 44 - component 433, 437, - -, deficiencies of the 388 - fixation 47, 70

complement-fixing antibody 69 conalbumin 39 congestion 117 congestive heart failure 116, 120, - right-heart failure 226

Congo red 15 connective tissue disease 48, 260, 296 constrictive pericarditis 117, 226 contrast media 15 - -, intravenous 172

control serum 162 convulsion 140 copper 33, 34, 39, 385 -, albumin-bound 33 -, ceruloplasmin-bound 33

copro-antibody 143 corticosteroid-binding globulin 24 cortisol 24 cortisol-binding globulin 24 co-repressor Ill

INDEX

C-polysaccharide, pneumococcal 263 crash syndrome 140 C-reactive protein 78, 104, 112, 129, 261,

262, 425, cretinism 292 Crohn's disease 226 CRP 262 (see C-reactive protein) -,g- 263 -,m- 263 - test 299, 307, 337,

cryo-Bence Jones protein 333, 335, 347 cryofibrinogen 295, 346, 347, 375 cryoglobulin 346, 347, 375 cryoglobulinemia 34 7 -,essential 347 -,symptomatic 347

cryo-precipitating factor 348 cryo-precipitation 346 cryoprotein 34 7 crystalizable fragment 58 Cushing's syndrome 265 cyanide 33 cyclophosphamide 414 cvst content 125 cysternal fluid 126 cystic dilatation of the rough-surfaced endo­

plasmic 336, 342 -,fibrosis 145, 201, 226

cytochrome 44 cytochromophilin 42 cytomegalic inclusion disease 438 cytomegalovirus mononucleosis 347

D

DEAE-cellulose column chromatography 44 defect dysproteinemia 380 defibrinating syndrome 53 defibrination state 134 - syndrome 390, 392

degradation rate, daily 101 - -,fractional 101

delipidation 81 delayed-type skin reaction 72, 396 delivery 260 <5 chain 66 demyelinating disease 292 densitometer 159 deoxyribonucleic acid I 08 dermatitis herpetiformis (Duhring) 228 dermatomyositis 276, 292, 295 dextran, Fe-labelled 147 - ingestion 133

diabetes mellitus 89, 201, 356, 421, 437 diabetic glomerulosclerosis 118, 218 - nephropathy 139

diethyldithiocarbamate 33 diffuse scleroderma 300 Di George syndrome 394, 411 digestive fluid 135 digitonin 15 di-nitro chlorobenzene 396 discrete peak 311 disulfide bond 4 disulphide knot 51 diverticulitis, jejunal 226

DNA 108 DNCB 396 (see di-nitro chlorobenzene) Donath-Landsteiner antibody 373 dopa 34 Doppelparaproteinaemie 317 double albuminemia 12 Down's syndrome 400 drug eruption 228 dummy-protein 112, 323 duodenum 145 dysfibrinogenernia 37 5 dysgammaglobulinemia 401 dysproteinemia 374

eclampsia 429 eczema 228 edema 115, 155 ~,lymphatic 223 ~, nephrotic 220* ~ fluid 117

EDTA 45

E

electrophoresis, cellulose acetate 193 ~ filter paper 193 ~,free 6 ~,polyacrylamide gel 29 ~,starch gel 30

electrophoresis in various supporting media 6 elephantiasis 119, 224 Elson-Morgan reaction 76 embryonal cell I 06 embryonal testicular tumor 379, 433 emphysema 383 ~,juvenlie 21, 383 --, pulmonary 21

encephalopathia hyperglobulinaemica 302 endocarditis, subacute bacterial 275, 279,

347 endocrine organ 115 endocrinopathy 201, 260 endoplasmic reticulum 106 ~ ~,rough-surfaced 106

enteritis, regional 226 enterocolitis, infantile 226 epidermal cell I 06 epidermolysis bullosa 228 episodic lymphopenia with lymphocytotoxin

410 e-aminocaproic acid 53 e chain 66, 73 equilibration time method 102 erythema multiforme bullosum 228 erythrocyte sedimentation rate 337 ~ stromal protein, non-hemoglobin 169

erythropoietin 7 5, 78 ESR 274, 337 essential hypoproteinemia 206 esterase 24 estrogen 24, 35 estrogen-sensitive protein 424 euglobulin 345 exocrine cell I 06 ~ organ 132

extrapolation method 102 exudate 119

INDEX

exudative dermatopathy ~ pulmonary disease

206, 228 206, 231

455

F

Fab 58, 62, 70 Fab fragment 58 F(ab')2 58, 70 factor I 50 factor VII I 04 factor XIII 52 Fanconi syndrome 141 fat-soluble vitamin 87 fatty acid 15, 82, 87 Fe 58, 62 ~ frament 70

FDP, immunochemical characteristics of 53 FDP, physico-chemical characteristics of 73 Fd piece 59 feedback control 112 Felty's syndrome 300 female genital secretion 135 fetal haptoglobin 434 ~ hemoglobinemia 436 ~ protein 432

fetuin 433 fetus 431 fever 134 fibrin 50, 52, 265 fibrin-i, urea-insoluble 52 fibrin-s 52 ~, urea-soluble 52

fibrin-stabilizing factor 52 fibrinogen 50, 75, 77, 104, 131, 132, 134,

173, 218, 233, 245 252, 261, 262, 265, 274, 311' 426, 433, 437

~, abnormal 374 ~, biological characteristics of 51 ~, chemical characteristics of 50 ~, chemical structure 50 ~, clinical abnormalities of 53 -, cryo-precipitable of 51 -, immunoelectrophoretic characteristic of

51 fibrinogen Cleveland 377

- Detroit 377 - Los Angeles 377 -, physical characteristics of 50

St. Louis 377 - Zurich 377 - degradation product 53 (see FDP)

fibrinogenolysis 53 fibrinolysis 50, 77 -, accentuation of 54, 393

fibrinolysopeptide 53 fibrinopeptide 377 fibroblast 106 filaria 233 filariasis 141, 226 flotation rate 80 fluorescent antibody technique 104 5-fluorouracil 414 framgent D 53

E 53 - y 53 -X 53

456

Franklin disease 312 folic acid antagonist 414 FTA-ABS test 275 fucose 76, 77

galactosamine 76, 77 galactose 76 galactosemia 141

G

gall stone 416 yA-immunoglobulin 64 y chain 58 y chain disease 312, 362, 364 yD-immunoglobulin 66 y-fraction 56 y-fraction, modal mobility of the 268, 397,

399 y-globulin 56 7S y-globulin 63 19Sy-globulin 63 YIA-globulin 64 y,-macroglobulin 63 3S y,-g!obulin 56 )'2-globulin 57 2S Y2-globulin 56 0.58 )'2-globulin 56 yG-immunoglobulin 57 yM-immunoglobulin 63 yMs 63, 64 y.,-globulin 57 gammopathy, monoclonal 267 -, polyclonal 267

gargoylism 416 gastrectomy 20 I, 226 gastric carcinoma 226 - JUICe !35, 142

gastritis 292, 356 -, atrophic 226 -, giant-fold 226 -, hypertrophic 226 -,ulcerative 226

gastrointestinal bleeding 145 gastrointestinal tract 132, 145 Gaucher's disease 416, 421 Gc-factor 26 Gc-globulin 26, 75, 104 (see Gc) Gc, hereditary types of 26 -, immunoelectrophoretic characteristics of

27 Gc, physico-chemical characteristics of 26 gel filtration 6 - filtration technique 207 - immunoelectrophoretic method 7 - reaction, acid 274 - -,alkali 274 - -,formal 274 --,heat 274 --,urea 274 --,urethane 274

gene mutation 113 genital organ 132 germinal center I 04 Gitlin's syndrome 407 glomerular filtrate 135 glomerulonephritis 139

INDEX

glomerulonephritis, acute 36, 48 glucosamine 76, 77 glucose 76 gluten enteropathy 226 glycogen-storage disease 89 glycoprotein 74, liO, 259 -, a1-acid 75 -, a,-easily-precipitable 75 -, a2HS 75 -, a1-neuroamino 75 -, biological characteristics of 77 -, chemical characteristics of 76 -,clinical abnormalities of 78 -, nomenclature 74 -,tryptophan-poor-a, 75 -, Zn-a2 75

Gm factor 60 Gm-phenotype 60 Gm system 60 Golgi apparatus 106 Good syndrome 404 gout 421 group-specific components 26 (see Gc) growth hormone 266 Guillain-Barre syndrome 129

H

Half's disease 140 half-time survival 101 Hand-Schiiller-Christian disease 416 haptoglobin 8, 27, 35, 75, 77, 78, 103, 131,

132, 134, 168, 215, 243, 249, 261, 352, 425, 433, 437

haptoglobin-hemoglobin complex 31, 134 Hashimoto's disease 293, 294, 356, 357 HbH 32 H chain 57 heat labile component 24 heavy chain disease 140, 312, 362 heavy polypeptide chain 57 hemagglutination 71 hemaglutinin, cold 71 -, iso 71

heme 43 heme-binding a-globulin 42 hemoconcentration 16, 175 hemochromatosis 247 252 hemoglobin 31, 44, 166, 311 -, abnormal 32 -,Barts 32 -,fetal 13

hemoglobinuria 140 -, paroxysmal nocturnal 49

hemolysis 4 7 -, in vitro 166 -, in vitro 32

hemolytic anemia 32, 44, 134, 292, 347 hemolyzed serum 31, 168 hemopexin 40, 42*, 75, 104, 134, 243 -, biological characteristics of 43 -, chemical characteristics of 42 -, chemical structure 43 -, clinicaf abnormalities of 44 -, immunoelectrophoretic characteristics of

43

hemopexin-heme complex 44 hemophilia 276, 277 hemoptysis 135 hemosiderin 42 hemosiderosis 386 heparin 171 hepatectomy 113 hepatic damage 16, 17, 20, 21, (see liver

damage) - congestion 120

hepatitis 237, 240, 356 -, acute 32, 35, 42, 240 -, cholangiolitic 255 -, chronic 240, 244, 292 -,fulminant 240, 242, 379 -,infantile 244 -, infectious 240 -,lupoid 241, 246 -,neonatal 245, 379 -,plasma protein changes m 241 -,serum 240 -, subacute 244 -,toxic 241 -,viral 240 -, virus, carriers of the 246

hepatocellular carcinoma 377 hepatolenticular degeneration 385 hepatoma 120, 240, 252, 379, 433 hereditary angioneurotic edema 388 heteroagglutinin 395 heterolysin 395 hexosamine 74, 76 hexose 76 high-density lipoprotein 254, 417 - - deficiency 388

Hirschsprungs's disease 226 histamine 15, 73 histiocytoxis X 416 Hodgkin's disease 226, 288, 313, 356, 366,

412 Hoffs-Jacobs disease 312 homograft rejection 396 hormone 22, 265 -, anterior pituitary 22 -,follicle-stimulating 75 -,interstitial cell-stimulating 75 -, pancreatic 22 -, parathyroid 22 -, posterior pituitary 22 -, thyroid 22

hormone-binding plasma protein 22 hormone-protein interaction, detection of 22

- -, physiological singificance23 Hp, biological characteristics of 31 -, chemical characteristics of 28 -, chemical structure 28 -, clinical abnormalities of 32 -, hereditary types of 29

INDEX 457

hyperalphaglobulinemia, classification of 260 hyperalphaglycoproteinemia 259 hyperbeta- and pre-beta-lipoproteinemia 89 hyperbeta-lipoproteinemia 89 hypercalcemia 352 hypercalcemia, idiopathic 421 hypercalciuria 281 hypercholesterolemia 415 hyperchylomicronemia 89 hypercupremia 352 hyperemesis gravidarum 429 hyperfibrinogenemia 53 hypergammaglobulinemia 251 hypergammaglobulinemic state 278

- pattern, polyclonal 311 hyperglyceridemia 218, 415 hyperglycoproteinemia 78 hyperhaptoglobinemia 32 hyperimmunization 279 hyperimmunoglobulinemia 267 -, essential 269, 300 -,monoclonal 267, 274 -, polyclonal 73, 267, 273, 313, 356,

hyperlipemia 218, 415 -,bleeding 232 -,carbohydrate-induced 415 -,endogenous 415 -,exogenous 415 -,fat-induced 415

hyperlipemic state, dietary (or postprandial) 166

hyperlipexia 416 hyperlipidemia 309, 415 hyperlipoproteinemia 89, 219, 415 -,familial 418 -, primary 420 -,secondary 421

hyperlipoproteinemic state, dietary 421 - -,postprandial 421

hyperphospholipidemia 415 hyperprealbuminemia 17 hyperpre-beta-lipoproteinemia 89 hyperproteinemia 157 hypersensitivity 273 - angitis 297 -,delayed 280

hypersensitization, experimental 280 -, protracted 269

hypertension 356 hypertensive cardiac disease 199 hyperthyroidism 266 hyperviscosity syndrome 302, 340, 341, 352 hypoalbuminemia 42, 228, 229, 231

-, immunoelectrophoretic characteristics of 30

-,acquired 16 hypobetalipoproteinemia 89, 389 hypofibrinogenemia 390, 429 hypogammaglobulinemia 73, 201, -412 hypoglycoproteinemia 78 hypo-immunoglobulinemia 267 hypokalemia 141 -, physical characteristics of 28

Hp-Hb A complex 168 H-polysome 362 humoral antibody 69 hyaluronic acid 123 hyaluronidase 124, 266 - inhibitor 78

hypolipoproteinemia 89 hypohaptoglobinemia 32 hypoparathyroidism 201 hypoprealbuminemia 17 hypoproteinemia 35, 42, 117, 157, 199, 222,

228

458

-, endocrine 234 -, essential 233 -, hemodilutional 234 -, l:typercatabolic 233, 234 -, idiopathic 226 -,hepatic 234 -, mal-distributional 234 -, mal-nutritional 234 -, protein-losing 234 -, pregnancy type 234

hypothyroidism 89, 201, 266, 422 hydrazine 47 hydrocele 120 hydrocephalus 126, 128 hydroquinone 34 4-hydroxyazobenzene-carboxylic acid 16 hysterectomy 54

I

idiopathic respiratory distress syndrome 437 - thrombocytopenic purpura 292

idiotype 60 IgA 65, 68 -, chemical characteristics of 64 -, chemical structure 64 -, hereditary types of 65 -, immunoelectrophoretic characteristics of

65 -, physical characteristics of 64

7S lgA 65 IgA2 65 IgA-immunoglobulin 64, 75, 115, 131, 433,

437 (see IgA) IgD 66, 68, 312, 367 - fragment 331

!gO-immunoglobulin 66 (see IgD) IgE 72, 312 IgE-immunoglobulin 279 (see IgE) IgE-producing plasma cell 73 IgG 68 -, chemical characteristics of 58 -, constant portion of 60 -,hereditary types of 60 -, heterogeneity 59 -, immunoelectrophoretic characteristics of

60 -,physical characteristics of 57 -, variable portion of 60

IgG 1 60, 62, 73 IgG 2 60, 61, 73 IgG 3 60, 73 IgG 4 60, 73 IgG-immunoglobulin, a structural model of the

70 lgG-immunoglobulin, chemical structure 58 IgG-immunoglobulin, heterogeneity of the 58 IgG-immunoglobulin 45, 57, 75, 115, 131,

132, 133, 433, 437 (see IgG) IgM 68, 383 -, chemical structure 63 -, chemical characteristics of 63 -, hereditary types of 63 -, immunoelectrophoretic characteristics of

63 -, physical characteristics of 63

INDEX

7S lgM 63 - disease 312

lgM-immunoglobulin 63, 75, 131, 274, 433, 437

IgND 66 ileum 145 immune complex 348 - deposit 217 - adherence reaction 4 7

immunoglobulinopathy 89 immunodeficiency 73, 317, 356 immunodeficiency, primary 399 -, primary lymphopenic 407 -, secondary 411 -, severe combined 410 - syndrome 393 - with ataxia-telangiectasia 406 - with short-limbed dwarfism 406 - with thrombocytopenia and eczema 405 - with thymoma 403

immunoglobulin 56, 104, 129, 217, 227, 244, 246, 250, 265, 267, 286, 287, 438

-,antibody activities of the 68 -, biological characteristics of 68 -, clinical abnormalities 73 -,fundamental structure of the 57 -, monoclonal 305 -,normal serum concentration of the 68

. -, pathological 305 -,physiological characteristics of 72 -,serum 395 -,abnormality 267

immunoglobulin-fragmenturia 364 immunoglobulin-producing cell 104, 287 immunoglobulin-producing tissue 273 immunoglobulinopathy 89 -, monoclonal 286

immunoproliferative disorder 288 immunosuppressive agent 414 immunosuppressive factor 414 immunosuppressive therapy 411 impotent neutrophil syndrome 404 inducer 110 infantile amaurotic family idiocy 416 infected abortion 134 infection 3 7, 155 -, chronic 278 - disease 260, 269, 438

infectious mononucleosis 49, 347 inflammatory disease 20, 21, 32, 35, 42, 48,

78, 134 -process 53

inherent error 159 inhibitor of virus hemagglutination 75 insulin 36, 266 - lipohypertrophy 416

inter-a-trypsin-inhibitor 36, 75 interatrial septal defect 226 interstitial pulmonary fibrosis 296 - tissue fluid 117

interstitium 115 intestinal diverticula 20 I - fistula 201 -fluid 146 -JUICe 135, 142 - stricture 201

- tuberculosis 226 - villi 115

intracranial tumors 129 intraplasmocytic protein-viscosity index 343 intravascular blood coagulation 134 in utero retention of dead fetus 134 In V system 60 I.P.P.V.I. 343 I.R.D.S. 437 iron 39, 41 iron-binding capacity, total 41 iron-deficiency 356 - anemia 42, 386

iron intoxication 42 - metabolism 41 - transferrin complex 41

irradiation 113 islet cell tumor20 I iso-hemagglutinin 395 !-specificity 369 ITP 292

jejunum 145 ]-fragment 28 joint disorder 155

kala-azar 279, 34 7 "(kappa) chain 57 keratin 106 keratohyaline 106 kidney 115, 132 -,artificial 116

Kiliani reaction 82 Kveim reaction 281 kwashiorkor 201, 226

L chain 57

J

K

L

labyrinthine fluid 143 lacrimal gland 132 lactate dehydrogenase 36 lactotransferrin 39 LE cell phenomenon 276 J. (lambda) chain 57 leishmaniasis 279 lepra 366 leprosy 347 Letterer-Siew disease 416 leukemia 35, 49, 73, 223, 226, 261, 262, 276,

317, 347, 412 Libermann-Burchard reaction 82 Libman-Sacks disease 218 lichen planus, bullous 228 light polypeptide chain 57 lipase deficiency 20 I -,hormone-sensitive 88

lipemia-clearing factor 78 - - -,inhibitor 75

lipid 22 · -,plasma 87 lipidosis 415

INDEX

lipid-protein complex 79 lipoid nephrosis 212 lipopathy 415, 416 lipophilic dye 81 lipoprotein 79, 104, 426 -, a1- 75, 81, 84 -, a2- 75, 85 -, fl- 75, 81, 85 -, biological characteristics of 86 -, chemical characteristics of 84 -, clinical abnormalities of 89 -,deficiencies of 388 -, electrophoretic analysis of 80 -, hereditary types of 85 -, high-density 79, 82

459

-, immunoelectrophoretic characteristics of 85 -, in the obstructive liver diseases 254 -, low-density 79, 82 -, nomenclature 79 -, obstructive 256 -, physical characteristics of 82 -,plasma 87 (see lipoprotein) -, pre-{3 79, 81, 85, 88 -,serum 87, 88 (see lipoprotein) -, slow-migrating 256 -, ultracentrifugal analysis 80 -, very high-density 82 -, very low-density 82

liver 115 -,metastatic carcinoma of the 120 -,subacute yellow atrophy of the 251

cell 105, 108 - cirrhosis 32, 54, 112, 116, 120, 121, 133,

238, 240, 242, 247, 248,276,345, 347, 356 - damage 32, 35, 53, 78, 89, 201, 236 - diseases 73, 240, 242, 269, 277 - -, obstructive 252 - disorder 276 (see liver damage) - haptoglobin 104

local immunity 143 Louis-Bar syndrome 406 low-density-lipoprotein 214, 236, 254, 311,

417, 433, 253 Lp-system 85 lumbar fluid 126 lung 115 lupus nephritis 216, 218, 299, 301 lymph edema 116 -,hepatic 115

lymphadenosis hyperglobulinaemica 289 lymphangiectasia, intestinal 223 lymphangioma 141 -, retroperitoneal 226

lymphatic leukemia 288, 358 - obstruction 116 -, tissue, congenital malformation of the

223 lymphedema 117, 226 -,congenital 118

lymphoblastic transformation 396 lymphocytoid plasma cell 104 lymphogranuloma venereum 275 lymphogranulomatosis inguinale 279 lymphoma 201, 226, 317, 347, 412 -,abdominal 364

lymphoproliferative disorder 288, 356, 365

460

lymphoreticulosis hyperglobulinaemica 289 lymphorrhea 206, 233 lymphosarcoma 223, 226, 288, 412 lysin 69

M

macroglobulinemia 345, 355, 369 -,primary 73, 307, 312, 328, 338, 344,

347, 355 - Waldenstrom 140

macroglobulins 115 manganese 39 malabsorption syndrome 35, 202*, 364 male genital secretion 135 malignancy 73, 78, 89, 201, 260, 264, 269,

276, 284, 376 -, non-reticular 284 -,reticular 287, 406, 411

malignant lymphoma 73 - tumor 20, 21, 35

malnutrition 16, 20, 21, 53, 78, Ill, 116, 133, 201

malnutritional serum protein pattern 260 mannosamine 7 4 mannose 76, 77 marasmus 201 materno-fetal transfer 438 marathon racing 177 M-components 129, 305 mecraptoethanol treatment 327 mediastinitis fibrosa 292 mediastinum, benign teratoma of the 125 megacolon 226 -, congenital 146

membranous nephropathy 217 Menetrier's disease 226 meningitis 129 -,benign lymphocytic 130 -,tuberculous 130

mercaptalbumin 12 mercaptoethanol 64 - treatment 326

mesenteric artery insufficiency 20 I mesothelium 123 messenger RNA 109 metabolic product 22 metachromasia 366 metafibrin 53 metal ion 22 methanol intoxication 54 methylpentose 76 M-fraction 305 microangiopathy (diabetic) 416 middle lobe syndrome 359 milk 135, 143, 439 mitochondria 106 mitochrondrial RNA 109 mitomycin C 414 molecular aggregation 336, 340 monoclonal gammapathy 305 - hypergammaglobulinemia 305 - immunoglobulinopathy 73 - -, essential 73

6-MP 414 M-protein 205, 305

INDEX

-,a type 332 -,disappearance of 314 -,y type 332 -, IgA type 324, 326 -, IgG type 318, 332 -, lgM-type 326, 369 -, 7S IgM type 332 -,!-'type 333 -, IgD type 327 -band 305 - band, wavy 336, 341, 360

M-proteinemia 244, 305, 408, 421 -,double 316 -,essential 307, 312, 315, 317, 355 -,familial occurrence of 314 -, IgD type 331 -, serum lipids in the 309 -, of the minor anomaly type 307

mRNA 109 I' chain 63 I' chain disease 312, 364 muco-antibody 143 mucopolysaccharide 136 -,acid 264

mucopolysaccharide-protein complex 74 mucoprotein 74 multicompartmental analysis 102 multi-pipe model 102 multiple myeloma 73, 112, 288 (see myeloma) - sclerosis 35, 130, 292

muscle 115 muscular dystorophy 140 myasthenia gravis 292 mycoplasma pneumonitis 369 myelofibrosis 287, 356 myelogenous leukemia 287, 356 myeloma 49, 140, 338, 342, 359 -cell 343 -, IgG type 345 -,lgM type 355 - kidney 141, 352 -,multiple 139, 307, 312, 316, 317, 320,

325, 326, 331, 335, 347, 350, 352*, 354 -,solitary 127, 351, 353

myeloproliferative disorder 287, 356 myocardial infarction 118, 260, 264, 356 myocyte 106 myoglobulinuria, familial paroxysmal 140 -,fetal 140

myositis 140 myxedema 116, 266, 292, 422

nasal fluid 135 - secretion 143

necrosis 113 necrotizing prosess 53 neomycin 021 neonatal period 437

N

- serum protein 434 neoplastic cell I 06 neosalvalsan 15 nephrectomy 214 nephritis 208, 356 nephrosis 208, 416

nephrotic edema 116 syndrome 17, 20, 21, 35, 36, 78, 89,

116, 139. 190, 206, 207, 210, 226, 260, 338, 345, 387, 422

-, classification of the 21 0 -,plasma protein changes in the 213

neuraminic acid 74, 77 neuraminidase 128 neuro-psychiatric condition 201 neurosyphilis 130 neutral fat 82, 87 neutralizing antibody 69 Nezelof's syndrome 410 Niemann-Pick disease 416, 421 nitrogen mustard 414 non-secretory cell I 06 non-selective protein-losing serum protein

pattern 260 normal value 186 normoblast 106 nucleic acid 108 nutritional disorder 155

0

obesity 416 obstructive jaundice 89, 20 I, 422

- liver disease 240 o-dianidine staining 31 operator gene 110, 112 operon theory II 0 opsonin 69 opsonin, immune 71 -,normal (or natural) 71

opsonization 71 orchitis 292 orcinol 76 orosomucoid 18 osmotic pressure 114, 116 osteoarthritis deformans 297 osteomalacia 356 osteomyelitis 366 oxalate 171 oxidase activity 34 ozone-Schiff staining 81

p

pancreas, carcinoma of the 123 pancreatic fistula 20 I -juice 135

pancreatitis 89, 20 I, 421 -, hemorrhagic 44

panniculitis 297 panperitonitis 431 para-at acid glycoproteimemia 20 paraffin 280 parafibrinot;(en 374, 377 paralbuminemia 16, 53, 374 paraimmunoglobulin 375 paraimmunoglobulinopathy 305 paralbumin 375, 377 paralbuminemia 12, 377 paraminosalicylate 15 para-phenylenediamine 34 paraprotein 374

INDEX

paraproteinemia 374 parathyroid hormone 266 paroxysmal cold hemoglobinuria 292, 373 - nocturnal hemoglobinuria 49

pemphigus 276 - vesicle 117 - vulgaris 120, 228, 229

penicillamine 64 penicilline 15 peptic ulcer 356 peptide A 52 - B 52

pericardia! fluid 121 periarteritis nodosa 34 7 pericardia! cavity 120 -fluid 120

peritoneal cavity 120 peri to neal perfusion 116 peritonitis 120 permeability ratio 206, 208 pernicious anemia 292 peroxidase reaction 31 PHA 396 (see phytohemagglutinin) phacoanaphylaxis 292 phagocytosis 4 7, 71 pharyngeal pouch syndrome 411 phenacetin intoxication 141 phenol red 15 <jJ (phi) fraction 50, 173 PHLA 311, 352 phospholipid 82, 87 piecemeal necrosis 24 7 placenta 438

461

placenta, premature detachment of the 134 plasma cell 104, 105, 107, 360

dyscrasia 305 leukemia 288, 328

plasma protein, catabolism of the 131 -, external loss of the 135

- -, metabolism of the 99 in the cadavers 184 loss 206 -, selectivity of 206 measurement ]59

plasma volume 101 plasmacytoma 288 -,half-molecule lt;(G type 312

plasmacytoid lymphocytes 104 plasmapheresis 133, 206, 208, 232 plasmin 36, 53 plasminogen 54, 75, 77 plasmodial infection 279 platelet cofactor 77 pleural cavity 120 - fluid 120, 121, 207, 208 - puncture 206

pleuritis, carcinomatous 207 - carcinomatosa 123

pneumonia 49, 231 -,lobar 231,257 -, pneumococcal 258

polyant;(itis nodosa 292 polyarteritis nodosa 275, 295 polyclonal hyperimmunoglobulinemia 269 polycythemia 287 polyneuritis 130

462

polypeptide 3 -chain 3

polysaccharide-protein complex 123 pooled serum 161 postalbumin, 4.6 S- 25 postheparin lipolytic activity 311, 352 post-irradiative syndrome 226 post-mastoplasty disorder 280 post-mature baby 437 post-mortem examination 184 ppd, dimethy- 34 Prausnitz-Kuestner reaction 72 prealbumin 16, 22, 115, 131, 213, 437 -, biological characteristics of 17 -,chemical characteristics of 16 -,chemical structure 16 -, clinical abnormalities of 17 -, immuno-electrophoretic characteristics of

17 -, physical characteristics of 16 -,thyroxine-binding 16 -,tryptophan-rich 16, 128

precipitation 6 precipitin 69 precision 162 preeclampsia 429 pre-fibrin 52 pregnancy 23, 24, 35, 42, 78, 89, 117, 260,

276, 338, 421, 423 premature baby 437 profibrin 52 progesterone administration 421 properdin 48 -, biological characteristics of 48 -, clinical abnormalities 49 -, immunoelectrophoretic characteristics of

48 -, physico-chemical characteristics of 48

prostatectomy 54 prostatic hypertrophy 356 - secretion 144

protein 3 -, conjugated 3 -, fundamental structure 3 -,monomeric subunits 5 -, primary structure of 4 -, quaternary structure of 5 -, secondary structure of 4 -,simple 3 -,tertiary structure of 4

protein-bound carbohydrate, normal serum concentration of 76

protein deficiency, genetic causes of 112 protein error of indicators 136 protein fractionation 6 protein-losing, non-selective 204 -,selective 204 - condition 16, 73, 204 - gastroenteropathy 35, 145, 146, 206, 222 - gastroenteropathy, classification of the 222 - hypoproteinemia 299

proteinuria 155 -, febrile 140 -,glomerular 139 -, lordotic 139 -,orthostatic 139

INDEX

-,physiological 141 -,postural 139 -, prerenal 139, 140, 265 -, tubular 141 - in the nephrotic syndrome 211

prothrombin 75, 77, 104 protracted sensitization 279 --,experimental 314

pseudo-Bence Jones protein 333 pseudo-cholinesterase 36 pseudo-deficiency 112 puerperium 426, 428 pulmonary abscess 231 -cancer 231

pulmonary edema 231 - gangrene 231, 356 - stenosis 226 - tuberculosis 248

purine antagonist 414 purpura 347 - hyperglobulinaemica 292, 302

PVP, 131J-labelled 147 pyelonephritis 141, 356 pyothorax 119 pyrimidine antagonists 414 pyrocrit 349 pyrogallol 34 pyroglobulinemia 320, 349 pyroglobulin 349 pyloric insufficiency 20 I pyruvic acid 74

Q

quality control program 161

R

radioactive carbon 103 -iodine 100 - iodine-labelled plasma protein 100

radioactivity distribution rate I 02 RA test 276, 300, 314 Raynaud's symptom 349 reagin 72, 275, 279 reaginic activity 66 rectum 145 -, carcinoma of the 258

refractometer 159 regional ileitis 201 regulator gene 110, 112 renal biopsy 222 - clearance 208, 209 - disorder 155 - glomerulus 206 - transplantation 205, 378

repressor 110 reproducibility 162 resorcinol-HCI reaction 76 respiratory organ 132 reticular dysgenesis 411

- tissue, non-neoplastic proliferation of the 289

reticulocyte I 06 reticuloendothelial system I 04 reticulosarcoma 356

reticulosis 34 7 reticulum cell sarcoma 122, 288, 412 rheumatic fever 263, 275, 295 rheumatoid arthritis 125,246, 264, 275, 276,

292, 295, 299, 345, 347, 356, 366 rheumatoid tactor 71, 75, 275, 296, 327, 348 ribonucleic acid 108 ribosomal defect 112 ribosome 105, 108 Rivalta reaction 121 rivanol precipitation 251 RNA 108 -, adaptor 109 - polymerase 109

rouleaux formation of the erythocytes 274, 302, ::!36

rubella 431$

4.6 S-postalbumin 75 saliva 135, 142 sarcoid 226

s

sarcoidosis 269, 281, 292, 347 sarcoid-steps 283 salicylates 15 Schistosoma japonicum infection 252 sclerema neonatorum 416 scleroderma 20 1

- ditfusa 292 -,diffuse 276, 295

secretions 141 secretory cell 1 06

IgA 439 IgA-globulin 143 IgA-immunoglobulin 142 (or transport) piece 144

selective lgA deficiency 401 - immunoglobulin deficiency 401

seminal fluid 143 Sephadex G-200 208 septicemia 258, 387 -,pneumococcal 191

serological false positive reaction 273, 274 seromucoid 74, 78, 265 seromucoide a2 28 serotonin 34 serous fluid 120 serum colloid reaction 274, 344

gel reaction 274 globulin dyscrasia 403 lgA 300 sickness 48, 72 viscosity 274, 302, 336, 338

shock 260 Sia water dilution test 274, 345 sialic acid 74, 76, 265 sialoadenitis, chronic 292 siderophilin 37 silicosis, pulmonary 280 silico-tuberculosis 281 Sjogren's syndrome 291, 292, 296, 302, 347 skin 115 ski-jump slope 236 skin sensitization 72 skin-sensitizing antibody 279

INDEX

SLE 48, 275, 276, 292, 297, 301, 302 slow starter 402 Salomon-Kunkel disease 312 soluble RNA 109 specific immunologic unresponsiveness 403 sperm granuloma 292 spleen 115 splenomegalia hyperglobulinaemica 289 spondylitis 297 sprue syndrome 226 sputum 135 sRNA 109 starvation 111, 201 status hypergammaglobulinaemicus 278 steatorrhea 226 stenosis of the gastrointestinal tract 201 sterility 292 steroid, gonadal 22 Still's disease 297 stomach 145 streptokinase 54 streptomycin 15 stress 54, 78, 264 - syndrome 20, 21, 48, 134

structual gene llO, 112 STS 275 Sturge-Weber syndrome 399 subclass of IgG 321 sulfa drugs 15 Svedberg unit 80 sweat 135, 143 sympathetic ophthalmia 292 synovial fluid 123, 126, 300 synthesis of plasma proteins 103 synthetic organ 104 syphilis 347, 438

463

systemic lupus erythematosus 48, 134, 261, 276, 293, 297, 347 (see SLE)

T

Tangier disease 89, 388 TBG 23 -, biological characteristics of 23 -,clinical abnormalities of 24 -, physico-chemical characteristics of 23

TBPA 26 tear 135, 143 technical error 159 technical failure 159 temperature-viscosity index 340 testicular sac 120 tetanus 140 tetrahydro-cortisol 24 thalassemia 436 thio-barbital reaction 76 6-thioguanine 414 thoracic duct, obstruction (ligation) of the 226

- surgery 134 thrombin 52 thrombocytopenia 356 thrombolytic purpura 54 thrombosis 116, 260 -,renal vein 139

thrombotic thrombocytopenic purpura 292 thyroxine 17

464

thymic alymphoplasia 410 - aplasia 411

thymic hypoplasia 411 thymol 76 - turbidity test 344

thyroxine 15, 23 thyroxine-binding globulin 17, 22, 23, 75,

77, 216, 424 (see TBG) - - deficiency 384

thyroid hormone 134, 266 thyroiditis 292 -, chronic 292 -, De Quervain's acute granulomatous 292 -, Hashimoto's 292 -, Riedel's fibrous invasive 292

TIBC 426 tissue necrosis 17, 32 tonsil 73 total iron binding capacity of serum 426 toxemia of pregnancy 429 toxin, neutralization of 71 toxoplasmosis 438 TPE activity 36 TPHA test 275 TPI test 275 transcortin 24, 75, 77, 216, 424 -, biological characteristics of 24 -, clinical abnormalities of 24 -, physico-chemical characteristics of 24

transfer RNA 109 transferrin 38, 43, 45, 46, 75, 77, 104, 115,

128, 131, 132, 216, 227, 243, 249, 383, 426, 433, 437

-, biological characteristics of 40 -, chemical characteristics of 38 -, clinical abnormalities of 42 -,hereditary types of 39

INDEX

uremia 260 uric acid 15 urinary glycoprotein of Tamm-Horsfall 136 - protein 135

urine 207, 135 urokinase 54 uromucoid 136 uveitis 292

v vaginal secretion 143, 144 variation, age 182 -,between-individual 173 -,biological 188 -, diurnal 174 -, exertional 177 - in exhaustion 1 78 -,nutritional 180 -,physiological 173, 189 -, postural I 77 -,racial 180 -, seasonal 17 5 -,sexual 181 -,technical 159, 188 -, within-individual 173

vascular rupture 117 venous obstruction 116 ventricular fluid 126 vesicular content 208 villous adenoma 145 vitamin 22 265 - c 15, 266 - D intoxication 141 - E 87

vitreous humor 143

-, immunoelectrophoretic characteristics of 40

viral pneumonitis 369 virus, neutralization 71 Von Gierke's disease 421 -, physical characteristics of 38

-,slow-migrating 128 trauma 260 tracheobronchial secretion 135, 142 triglyceride 82 -,endogenous 88

triiodothyrohine 15, 17, 23 tRNA 109 tropical sprue 201 trypanosomiasis 130, 275, 279 trypsin 36 trypsin-protein esterase 36 (see TPE) tryptophane 76 TTP 292 TTT 344 tuberous sclerosis 226 tuberculin test 281 - type reaction 72

tuberculosis 201, 231, 356, 365, 366 turnover 131 -rate 131

two-compartment model 102

u

ulcerative colitis 142, 223, 226, 292, 294 ultracentrifugation 6 ultrafiltration 6

w Waaler-Rose test 276 water dilution test 274, 345 Watson-Crick's model 109 Weber-Christian's disease 297 Wegener's granulomatosis 296 300 302 Weil's disease 356 ' ' Whipple's disease 201, 226, 416 Wilson's disease 35, 141 247 384 wire-loop lesion 293 ' ' Wiskott-Aldrich syndrome 393, 405

xanthoma 309, 416 X-irradiation 414

Z-fraction 324 zinc 39

X

z

- sulfate turbidity test 344 zirconiosis 280 Zn-a2-glycoprotein 37 ZTT 344 Zwischen-fraktion 324 zymosan 45, 48, 49