797

INDEX

Volume 227, October-December, 1983

A134U, role in disposition of acy-clovir (dogs, rats), 644

Aarhus, L. L., see Vanhoutte, P.

M., 613Abel, P. W., see Hermsmeyer, K.,

322

Abernethy, D. R., see Arendt, R.M., 98

Acetaminophen, effect on hepatic

and arterial plasma glutathi-one and glutathione disulfide(rats), 749

Acetazolamide, diuretic effects,

pharmacodynamics of (man),

92Acetylcholine

in brain, elevation byLY141865 (rats), 354

release from brain, effects ofclonidine and norepineph-

rine (guinea pigs), 435Acyclovir, oral prodrug, disposi-

tion (dogs, rats), 644Adams, J. D., Jr., Lauterburg,

B. H. and Mitchell, J. R.:Plasma glutathione and glu-tathione disulfide in the rat:

Regulation and response tooxidative stress, 749

Adenylate cyclasemediation of coronary vasoac-

tivity of adenosine by (dogs),

316

multiple sites of action ofethanol on (mice), 551

Adler-Graschinsky, E., see Pesce,G., 205

Adrenoceptors

alpha, gastric inhibition by(rats), 478

alpha, postjunctional, blockadeby buflomedil (dogs), 613

alpha and beta, -mediated reninrelease in kidneys, role of cal-cium in interaction of (rab-bits), 144

alpha-i and alpha-2, in brain,modulation of neurons re-

leasing acetylcholine and �y-aminobutyric acid by (guineapigs), 435

alpha-2, effect on sleeping time(chicks), 421

a4tha-2, in mesenteric arteryand vas deferens, blockingaction of DG-5128 on (dogs,rats), 194

hepatic, ontogeny of (rats), 181Adrenoreceptors

alpha-2 and beta-2 in brain,binding by a-methylepine-phrine to (rats), 484

beta, regulation of secretoryevents in parotid cell by(rats), 238

Aghajanian, G. K., see Lakoski, J.M., 517

Agonists

atpha adrenoceptor, effects onincreased sleeping time

(chicks), 421

alpha adrenergic-induced con-tractions in veins and arter-

ies, effect of buflomedil on

(dogs), 613

-y-aminobutyric acid, suppres-

sion of withdrawal-related

audiogenic seizures (rats),663

Akima, M., see Sakai, K., 220Alcohol dehydrogenase, in liver,

effect of ethanol consump-

tion on (baboons), 78

N-Allylnormetazocine, antago-

nism of fentanyl-induced

bradycardia and hypotension

by (dogs), 302

Amfonelic acid, inhibition of

release of [3H]dopamine fromcaudate nucleus by (rabbits),446

Amikacin, effect on membranephosphoinositide metabolism

(rats), 409

-y-Aminobutyric acideffect on dopamine synthesis in

retina (rats), 627release from brain, effects of

clonidine and norepineph-

rine (guinea pigs), 435p-Aminohippurate, transport in

basolateral membrane vesi-des (rats), 122

p-Aminohippuric acid, impaired

transport in kidney, effect

of 1-(2-cloroethyl)-3-(trans-4-methylcyclohexyl)-1-nitro-sourea (rats),409

Aminooxyacetic acid, inhibitionof-y-aminobutyric acid trans-aminase by (rats), 627

Aminophyllinediuretic effects, pharmacody-

namics of (man), 92potentiation of prostacyclin by

(dogs), 2884-Aminopyridine

effect on electrical activity andcable properties of trachealsmooth muscle (dogs), 706

effect on transmitter releaseat neuromuscular junction(rats), 260

Aminopyrine, oxidation, effect ofethanol on (rats), 687

Amphetamine, inhibition of

release of [3H]dopamine from

caudate nucleus by (rabbits),446

d-Amphetamine

effect on isolated atria, compar-ison with �i-phenylethy1a-

mine (rats), 205effects of food deprivation on

oral self-administration of(monkeys), 28

Analgesia, induced by morphicep-tin (rats, mice, guinea pigs),

403

Analogs, of morphiceptin, struc-ture activity relationshipsand morphine-like activities(rats, mice, guinea pigs), 403

Anesthesia, effect on cimetidine

elimination (sheep), 441

Angiotensin II, effect on adrener-gic transmission in heart(dogs), 676

Annau, Z., see Katims, J. J., 167Antagonists

dopaminergic and serotonergic,effects on central thermoreg-ulation (rats), 383

of 5-hydroxytryptamine, be-havioral effects (rats), 557

of leukotriene, pulmonary ef-fects of (guinea pigs), 700

Anticonvulsants, teratogenic ef-

fects (rats), 274Antidepressants, effect on [3H1

spiperone binding to cortical

membranes (rats), 429

Antinociception, induced by footshock and morphine, a com-parison (rats), 42

Antipyrine, in vivo metabolism,correlation with hexobarbital(rats), 459

Antonelli, T., see Moroni, F., 435Aorta, effects of alpha adrenergic

receptor subtypes on calciuminflux/efflux in (rabbits), 60

Apomorphine, effect on body tam-perature (rats), 383

Arachidonic acid-induced vasodi-lation, effect of dazoxiben on(dogs), 790

Arai, M., see Nomura, F., 78Arbilla, S., see Kamal, L. A., 446Arendt, R. M., Greenblatt, D. J.,

deJong, R. H., Bonin, J. D.,

Abernethy, D. R., Ehrenberg,B. L., Giles, H. G., Sellers, E.M. and Shader, R. I.: In vitrocorrelates of benzodiazepine

cerebrospinal fluid uptake,pharmacodynamic actionand peripheral distribution,

98Armstrong, E. L., see Baer, P. G.,

600

Aromatase activity, ofovarian mi-

crosomes, effect of (3-naph-thoflavone on (rats), 248

Arteries, mesenteric, norepineph-

rine release and vascular re-sponse to nerve stimulationin (rats), 187

Arterycaudal, vasodilation by hydral-

azine in (rats), 322

coronary, effect of adenosine

receptors on relaxation of(dogs), 316

coronary, effect ofdazoxiben onthrombosis of (dogs), 790

mesenteric, alpha-2 blockingaction of DG-5128 in (dogs,rats), 194

Atria, isolated, comparsion of ef-fects of ��f-pheny1ethylamineand d-amphetamine on(rats), 205

Au, J. L.-S., Walker, J. S. andRustum, Y.: Pharmacoki-netic studies of 5-fluorouraciland 5’-deoxy-5-fluorouridinein rats, 174

Awad, R., Payne, R. and Deth, R.C.: Alpha adrenergic receptorsubtype associated with re-ceptor binding, Ca� influx,

Ca� release and contractileevents in the rabbit aorta, 60

Baer, P. G., Armstrong, E. L., andCagen, L. M.: Dissociation ofeffects of xanthine analogson renal prostaglandins andrenal excretory function inthe awake rat, 600

Bai, S. A., Wilson, M. J., Walle,

U. K. and Walle, T.: Stereo-selective increase in propran-olol bioavailability duringchronic dosing in the dog, 360

Baraona, G. E., see Nomura, F.,78

Barbitone-induced sleep, poten-tiation by melatonin (mice,rats), 587

Barium-induced abnormal auto-

maticity, effect of lidocaineon (dogs), 578

Baron, S. A., Jaffe, B. M. andGintzler, A. R.: Release ofsubstance P from the entericnervous system: Direct quan-titation and characterization,365

Bass, P., see Fox, D. A., 538Baum, B. J., see Kousvelari, E. E.,

238Baum, T., see Sybertz, E. J., 621Beani, L., see Moroni, F., 435Behavior

discriminative stimulus effects

ofdextrorphan (pigeons), 723

discriminative stimulus effectsof diazepam (rats), 160

798 Index Vol. 227

discriminative stimulus effectsof nalorphine (monkeys), 563

effects of food deprivation onoral d-amphetamine andketamine self administration(monkeys), 28

operant, effects of agonists andantagonists on (rats), 557

schedule-controlled, effects ofpicenadol and its agonist andantagonist isomers on (pi-geons), 671

schedule-controlled, effects ofpostponement of injectionsof nicotine on (monkeys), 154

spontaneous climbing, inhibi-

tion by opiates (mice), 466Bend, J. R., see Smith, B. R., 491Benzalkonium chloride, effect on

enteric neurons in jejunum(rats), 538

Benzidine, prostaglandin H syn-thase-catalyzed activation of

(rabbits), 545

Benzodiazepinesdiscriminative effects of (rats),

160

pharmacokinetic properties ofdistribution, clearance and

uptake into cerebrospinalfluid (cats), 98

Bethanechol-induced elevation ofgastric acid secretion andmucosal blood flow, effects ofsympathetic nervous systemon (rats), 478

BHT-933, effect on digoxin car-diotoxicity, 683

Bianchi, C., see Moroni, F., 435Bick, P. H., see Holsapple, M. P.,

130

Binding

of [‘ThI]BE 2254 to brain, effect

of alpha adrenergic receptoragonists and antagonists on

(rats), 605of a-bungarotoxin to acetylcho-

line receptors (rats), 340of [3H]dihydroalprenolol to

beta adrenoreceptors, inhibi-tion by bromoacetyiprenolol-menthane (rats), 238

of [3Hloxotremorine with car-diac muscarinic receptors(rats), 570

of [3Hjprazosin to aorta, effectof phentolamine (rabbits), 60

of serum protein, elicited by ye-nous catheter (rats), 369

of [3H]spiperone to cortical

membranes, effect of 5-hy-droxytryptamine (rats), 429

of [3HJ-S-sulpiride and [3HIspi-

perone in striatum, compari-son of receptor sites (rats,

rabbits), 592

prostaglandin H synthase-cat-

alyzed to urinary bladder car-cinogens, comparative effects(rams, dogs, rabbits), 139

Bioavailability, stereoselective, of

propranolol (dogs), 360Black, K. A., see Eells, J. T., 349Bladder, urinary, comparative ef-

fects of prostaglandin H syn-thase-catalyzed binding of

two carcinogens in (rams,dogs, rabbits), 139

Blockade

adrenergic, of ventricular defi-brillation (rats), 716

of calcium channel, effect ofmethylenedioxyindenes on

(rabbits), 767Blood flow

coronary, effect of beta-i ache-nergic receptors on (dogs),333

mucosal, bethanechol-induced,effects of sympathetic ner-vous system on (rats), 478

Blood pressureeffect of LY53857 (rats), 327effects of epinephrine, ct-meth-

ylnorepinephrine and a-methylepinephrine on (rats),484

effects of opioids and nicotineon (dogs), 302

systolic, effects of norepineph-

rine and epinephrine on(rats), 254

Bolla, R. I., see Zenser, T. V., 139Bonin, J. D., see Arendt, R. M.,

98Borison, H. L., see Doherty, P. A.,

508

Boyd, M. R., see Kramer, R A.,409

Bradycardia, fentanyl-induced,antagonism by N-allylnor-

metazocine (dogs), 302Brain

amphetamine-induced hyper-phagia and obesity caused byinjections in (rats), 524

comparison of anticonvulsantpotential of -y-aminobutyricacid agonists after injectioninto (rats), 663

effects of alpha adrenergic re-ceptor agonists and antago-nists on (‘9]BE 2254 bind-ing to (rats), 605

effects of clonidine and norepi-nephrine on release of acetyl-choline and -y-aminobutyricacid from (guinea pigs), 435

effects of methylxanthine onnorepinephrine turnover in

(rats), 1elevation of acetylcholine levels

by LY141865 in (rats), 354formation of methotrexate po-

lyglutamate in (rats), 633neurobehavioral and neuro-

pharmacological effects ofneurotensin in (rats), 743

Brater, D. C., Kaojarern, S. andChennavasin, P.: Pharmaco-dynamics of the diuretic ef-fects of aminophylline andazetazolamide alone andcombined with furosemide in

normal subjects, 92Breese, G., see Kalivas, P. W., 229Breese, G. R, see Frye, G. D., 663Breimer, D. D., see van der Graaff,

M., 459Bremazocine, diuretic effects

(rats), 35

Bretylium, effects on systolic

blood pressure and heart rate

(rats), 254

Buflomedil, effects on responsive-ness of vascular smooth mus-

cle (dogs), 613

Bumetanide, pharmacokineticsand pharmacodynamics

(dogs), 51Burch, R. M., Wise, W. C. and

Halushka, P. V.: Prostaglan-din-independent inhibition

of calcium transport by non-steroidal anti-inflammatorydrugs: Differential effects of

carboxylic acids and piroxi-

cam, 84

Burghardt, B., see Kolis, S. J., 652Burks, T. F., see Porreca, F., 22

Caffeine, behavioral effects(mice), 167

Cagen, L. M., see Baer, P. G., 600Calcium

-dependent action potentials,

effects of opioid peptides on

(mice), 394

extracellular, effect of 3,4-dia-minopyridine on synaptictransmission in (frogs), 16

influx/efflux in aorta, effects ofalpha adrenergic receptorsubtypes (rabbits), 60

role in interaction of alpha andbeta adrenoceptor-mediated

renin release in kidneys (rab-bits), 144

role in vasoconstriction and de-

polarization in resistancevessels in hindquarters(rats), 621

tissue content in vas deferens,

effect of maitotoxin on(guinea pigs), 199

transport in liver, inhibition bynonsteroidal anti-inflamma-tory drugs (hamsters, rats),

84

Cannabinoids, effect on cardio-vascular and ventilatory de-pression (cats), 508

Carbachol-stimulated serotoninrelease from intestinal enter-ochromaffin cells, inhibitionby somatostatin (rabbits),

755

Cardiohemodynamics, of nicor-andil, comparison with nitro-glycerin (pigs), 220

Cardiotoxicity, of digoxin, role ofalpha receptors in (dogs), 683

Carcinogenesis, chemical, phar-macologic intervention of

(rabbits), 545Cardiovascular responses, to leu-

kotriene C4 (rats), 244Carla, V., see Moroni, F., 435Carroll, M. E. and Stotz, D. C.:

Oral d-amphetamine andketamine self-administrationby rhesus monkeys: Effects offood deprivation, 28

Catecholaminesconjugates, pharmacology of

(guinea pigs, dogs), 267paradoxical elevation of s� �i-

pathetic activity during intt

sion of (rats), 254

Caudate nucleus, inhibition byamphetamine of release of[3H]dopamine from (rabbits),446

Canero, I., see Roach, A. G., 421Cederbaum, A. I., see Dicker, E.,

687

Cellsenterochromaffin, intestinal,

regulation of serotoninrelease from (rabbits), 755

oxyntic, evidence for histamineH2 and H2 receptors in(guinea pigs), 115

parotid, effect of bromoacetyl-prenololmenthane on betaadrenergic elicited proteinexocytosis in (rats), 238

Cerebral cortex, effect of antide-pressants on [3H]spiperone

binding to (rats), 429

Cerebrospinal fluid, uptake ofbenzodiazepines in (cats), 98

CGS8216, benzodiazepine antag-onist, antagonism of stimuluseffects of diazepam by (rats),160

Chaillet, P., see Marcais-Collado,H., 466

Checler, F., Vincent, J.-P. and Ki-

tabgi, P.: Neurotensin ana-logs [D-TYR”] and ED-PHEUlneurotensin resistdegradation by brain pepti-dases in vitro and in vivo, 743

Chennavasin, P., see Brater, D.C., 92

Chang, J.-K., see Chang, K.-J.,403

Chang K.-J., Wei, E. T., Killian,A. and Chang, J.-K.: Potentmorphiceptin analogs: Struc-ture-activity relationships

and morphine-like activities,403

Ching, M. S., see Mihaly, G. W.,441

Chlordiazepoxide, suppression of

withdrawal-related audi-ogenic seizures by (rats), 663

Chlorisondamine, effects on sys-tolic blood pressure and heartrate (rats), 254

1 - (2 - Chloroethyl) - 3 - (trans-4 - methylcyclohexyl)- 1 -ni-

tro-sourea, nephrotoxicity

(rats), 409

Cholera toxin, stimulation of ad-

enylate c�clase by (mice), 551Cimetidine

antagonism of histamine-stim-ulated calcium activity by(guinea pigs), 115

induced depression of seroto-

nergic neurons in dorsalraphe nucleus (rats), 517

Classicalconditioning, of nictitat-

ing membrane response, ef-

fect of morphine on (rabbits),639

Clearanceof clofibric acid, effect of pro-

benecid on (rabbits), 739reduced, of clofibric acid in

renal dysfunction, effect of

1983 Index 799

uranyl nitrate on (rabbits),732

Clindamycin, neuromuscular ef-fects (snakes), 308

Clofibric acid-probenecid interaction, a renal

mechanism for (rabbits), 739reduced clearance in renal dys-

function, effect of uranyl ni-

trate (rabbits), 732Clonidine

effect on release of acetylcho-line and ‘y-aniinobutyric acidfrom brain (guinea pigs), 435

influence of prazosin and yo-himbe on contractile re-sponse of aorta to (rabbits),60

-methylxanthine interactions(rats), 1

Cocaine, antagonism of d-am-phetamine effects on atria by(rats), 205

Code, R. A., see Tang, A. H., 563Coen, E., see Vanhoutte, P. M.,

613

Cohen, M. L., Fuller, R. W. andKurz, K. D.: LY5357, a se-lective and potent seroto-nergic (5-HT2) receptor an-tagonist, does not lower bloodpressure in the sponta-neously hypertensive rat, 327

Colon, effects of 5-fluorouraciland 5’ -deoxy-5-fluorouridineon dimethylhydrazine-in-duced tumors in (rats), 174

Collins, A. C., see Howerton, T.C., 389

Commissaris, R. L., see Mokler,D. J., 557

Costentin, J., see Marcais-Col-lado, H., 466

Culling, A. J., see Davis, T. P., 499Cyclazocine, d- and 1-, effects on

foot shock-induced antinoci-ception (rats), 42

Cyclic AMP, accumulation in tra-cheal smooth muscle, effectof methacholine on (dogs),694

Dangman, K. H. and Hoffman, B.

F.: Antiarrhythmic effects ofethmozin in cardiac Purkinjefibers: Suppression of auto-maticity and abolition of trig-gering, 578

Daniel, E. E., see Kannan, M. S.,706

Davis, B. B. see Zenser, T. V., 139,545

Davis, T. P., Culling, A. J., Shoe-maker, H. and Galligan, J. J.:fi-Endorphin and its metab-

olites stimulate motility of

the dog small intestine, 499Dazoxiben, effect on platelet ag-

gregation, coronary arterythrombosis and vascularreactivity (dogs), 790

1-Deamino-8-D-arginine vaso-pressin, effects on urinaryprostaglandin excretion

(rats), 215Defibrillation, ventricular, effect

of adrenergic stimulation andblockade on (rats), 716

deJong, R. H., see Arendt, R. M.,98

de Miranda, P., see Good, S. S.,644

Dexoxadrol, comparison with le-

voxadrol to produce dextror-phan-like discriminative ef-fects (pigeons), 723

Dextrorphan, discriminativestimulus effects (pigeons),723

5’-Deoxy-5-fluorouridine, phar-macokinetics of (rats), 174

Depression, ventilatory and car-diovascular, effects of can-nabinoids on (cats), 508

Deth, R. C., see Awad, R., 60Dewey, W. L., see Snow, A. E., 423,4-Diaminopyridine

effect on synaptic transmissionin ganglion (frogs), 16

effect on transmitter releaseat neuromuscular junction(rats), 260

Diazepambehavioral interactions with

xanthines and adenosine de-rivatives (mice), 167

discriminative behavioral ef-fects of (rats), 160

Dibekacin, effect on membranephosphoinositide metabolism(rats), 409

Dicker, E. and Cederbaum, A. I.:Effect of ethanol and meta-bolic substrates on the oxi-dation of aminopyrine, form-aldehyde and formate by iso-lated hepatocytes, 687

Diethyl maleate, effect on hepaticand arterial plasma glutathi-one and glutathione disulfide(rats), 749

Diethylstilbestrol, effect on cell-mediated immunocompet-ence (mice), 130

Digoxin, inotropic and cardi-otoxic actions, role of alphareceptors in (dogs), 683

Diltiazem, hypotensive and di-uretic actions of (rats), 472

2,5-Dimethoxy-4-methylamphet-amine, behavioral effects(rats), 557

Dimethylhydrazine-induced co-

lon tumors, effects of 5-fluo-rouracil and 5’ -deoxy-5-fiuo-

rouridine on (rats), 174Diphenylhydantoin, prenatal ef-

fects (rats), 274Diquat, effect on hepatic and ar-

terial plasma glutathione andglutathione disulfide (rats),749

Distress vocalization, effect ofmorphine on (chicks), 376

Distribution, of benzodiazepines

into cerebrospinal fluid(cats), 98

Diuresiseffect ofkappa opioids on (rats),

35

effects of diltiazem and hydral-azine on (rats), 472

effects of furosemide, amino-phylline and acetazolamideand their combination on(man), 92

induced by bumetanide, effectofprobenecid on (dogs), 51

Doherty, P. A., McCarthy, L. E.

and Borison, H. L.: Respira-tory and cardiovascular de-pressant effects of nabilone,N-methyllevonantradol and�9-tetrahydrocannabinol inanesthetized cats, 508

Dopamineeffect on body temperature

(rats), 383inhibition of prolactin secre-

tion, effect of haloperidol andpyrroloisoquinoline (rats),652

metabolites in brain, effect ofLY141865 on (rats), 354

stimulation of adenylate cy-clase by (mice), 551

synthesis in retina, effect of -y-aminobutyric acid on (rats),627

(3HlDopamine, release from cau-date nucleus, inhibition byamphetamine (rabbits), 446

Doxey, J. C., see Roach, A. G., 421Dubocovich, M. L., see Zahniser,

N. R., 592

Dynamics, of methotrexate poly-glutamates in situ (rats), 633

Dynorphin, effect on gastrointes-tinal transit (mice), 22

Eells, J. T., Black, K. A., Tedford,C. E. and Tephly, T. R.:Methanol toxicity in themonkey: Effects of nitrousoxide and methionine, 349

Ehrenberg, B. L., see Arendt, R.M., 98

Electroshock-induced convul-sions, antagonism by mela-

tonin (mice, rats), 587Elimination, renal, of cimetidine

(sheep), 441

Elison, G. B., see Good, S. S., 644Embryo activity, effect of mor-

phine on (chicks), 376f�-Endorphin, motility effects and

metabolism of (dogs), 499End-plate currents, effects of

clindamycin and lincomycinon (snakes), 308

Enero, M. A., see Granata, A. R.,187

Enkephalin, Leu, effect on gan-glion action potentials(mice), 394

Enkephalinamide, D-Ala2-Met5-,effect on locomotor activityin nucleus accumbens (rats),229

Enkephalins, D-Ala2-D-Leu5- andD-Pen2-L-cys5-, inhibition of

gastrointestinal transit by(mice), 22

Enkephalin-(thr6), D-Ser�-L-, in-hibition of gastrointestinaltransit by (mice), 22

Enprofylline, effect on urinaryprostaglandin excretion

(rats), 600Epinephrine

effect on blood pressure andheart rate (rats), 484

effect on systolic blood pressureand heart rate (rats), 254

in brain, effect of LY141865 on

(rats), 354Epoxide hydrolase, role in preven-

tion of styrene 7,8-oxide-in-duced hepatotoxicity (rats),491

Epstein, M. L., see Fox, D. A., 538Ethanol

effect on adenylate cyclase(mice), 551

effect on alcohol dehydrogenasein liver (baboons), 78

effect on aminopyrine oxida-tion (rats), 687

inhalation, time course of tol-

erance to (mice), 150withdrawal-related audiogenic

seizures, suppression by -y-aminobutyric acid agonists

(rats), 663Ethchlorvynol, hypnotic and hy-

pothermic effects (mice), 389

Ethmozin, antiarrhythmic effects(dogs), 578

Ethylketazocine, effect on heartrate and blood pressure(dogs), 302

Excretionrenal, of prostaglandin, effects

of antidiuretic hormone on(rats), 215

renal, of sodium and water, me-diation by central beta adre-noceptors (dogs), 73

urinary, ofAl34U and acyclovir

(dogs, rats), 644urinary, of p-nitrophenylglucu-

ronide, sex differences in(rats),658

urinary, of prostaglandins, ef-fect of xanthines on (rats),600

urinary, of sodium, effects ofdiltiazem and hydralazine on

(rats), 472

Exocytosis, protein, beta adrener-gic elicited, inhibition by bro-moacetylalprenololmenthane(rats), 238

Fatty acids, nonesterified, effectson renal transport (rabbits),55

Fejes-Toth, G., Naray-Fejes-Toth, A. and Fr#{246}lich,J. C.:Acute effects of antidiuretichormone on urinary prosta-glandin excretion, 215

Fentanyl-induced bradycardiaand hypotension, antagonismby N-allylnormetazocine(dogs), 302

Fiekers, J. F., Henderson, F.,Marshall, I. G. and Parsons,R. L.: Comparative effects ofclindamycin and lincomycinon end-plate currents andquantal content at the neu-romuscular junction, 308

Fischer, H. R., see Hurwitz, A., 68

800 Index Vol. 227

Fitzpatrick, T. M., see lacopino,V. J., 244

5-Fluorouracil, pharmacokinetics

of(rats), 174

Food deprivation, effect on oral d-amphetamine and ketamine

self-administration by (mon-keys), 28

Foot shock-induced antinocicep-

tion, antagonism by naloxone

(rats), 42Forder, J. R., see Pitt, B. H., 531Forsberg, E. J. and Miller, H. J.:

Regulation of serotonin

release from rabbit intestinalenterochromaffin cells, 755

Fouts, J. R., see Smith, B. R., 491Fox, D. A., Epstein, M. L. and

Bass, P.: Surfactants selec-tively ablate enteric neuronsof the rat jejunum, 538

Fr#{246}lich, J. C., see Fejes-Toth, G.,

215

Frye, G. D., McCown, T. J. andBreese, G. R.: Characteriza-tion of susceptibility to audi-

ogenic seizures in ethanol-de-

pendent rats after microin-jection of -y-aminobutyricacid (GABA) agonists intothe inferior colliculus, sub-stantia nigra or medial sep-

turn, 663

Fuhrrnan-Lane, C., Ortiz, E. and

Shiverick, K. T.: Effects of �(-

naphthoflavone administra-

tion to pregnant rats on ate-

roid hormone biosynthesis

and metabolism in ovarian

microsomes, 248Fujiwara, M., see Yokotani, K.,

478

Fuller, R. W., Hemrick-Luecke, S.K., Wong, D. T., Pearson, D.,Threlkeld, P. G. and Hynes,M. D., III: Altered behavioralresponse to a D2 agonist,

LY141865, in spontaneouslyhypertensive rats exhibitingbiochemical and endocrineresponses similar to those innormotensive rats, 354

Fuller, R. W., see Cohen, M. L.,327

Furosemide

diuretic effects, pharmacody-namics of (man), 92

effect on pulmonary removal ofprostaglandin E1 in vivo (rab-bits), 531

Galligan, J. J., see Davis, T. P.,499

Galloway, M. P. and Roth, R. H.:Neuropharmacology of 3-iso-

butylmethylxanthine: Ef-fects on central noradrener-gic systems in vivo, 1

Galzin, A.-M., see Kamal, L. A.,446

Ganglion, sympathetic, effect of

3,4-diaminopyridine on syn-

aptic transmission in (frogs),

16

Garfield, R. E., see Kannan, M.

S., 706

Gastrointestinal transit, spinal

opioid effects on (mice), 22Gentamicin, effect on membrane

phosphoinositide metabolism

(rats), 415

Giles, H. G., see Arendt, R. M., 98Gillis, C. N., see Pitt, B. R., 531Gintzler, A. R., see Baron, S. A.,

365

Girard, A., see Marche, P., 415Gleason, J. G., see Weichman, B.

M., 700Glucuronidation, renal, sex differ-

ences in (rats), 658Glutathione

-depleted livers, role of epoxidehydrolase in prevention of

styrene 7,8-oxide-induced

hepatotoxicity in (rats), 491regulation and response to oxi-

dative stress (rats), 749Glutathione disulfide, regulation

and response to oxidativestress (rats), 749

Goldberg, M. R., see Tung, C.-S.,484

Goldstein, D. B. and Zaechelein,R.: Time course of functionaltolerance produced in miceby inhalation of ethanol, 150

Good, S. S., Krasny, H. C., Elison,G. B. and de Miranda, P.:Disposition in the dog and

the rat of 2,6-diamino-9-(2-

hydroxyethoxymethyl) -pu-rine (A134U), a potentialprodrug of acyclovir (644)

Goodman, M., see Rosenkranz, R.P., 267

Gordon, E. R., see Nomura, F., 78Gormezano, I., see Schindler, C.

W., 639Granata, A. R., Enero, M. A.,

Krieger, E. M. and Langer, S.Z.: Norepinephrine releaseand vascular response elic-ited by nerve stimulation inrats with chronic neurogenichypertension, 187

Greenblatt, D. J., see Arendt, R.M., 98

Grignolo, A., see Koepke, J. P., 73GTP, stimulation ofadenylate cy-

clase by (mice), 551

Haloperidoleffect on apomorphine hypo-

thermia (rats), 383effect on dopamine-inhibited

secretion of prolactinHalushka, P. V., see Burch, R. M.,

84

Hand, A. R., see Kousvelari, E. E.,238

Harden, T. K., Meeker, R. B. andMartin, M. W.: Interaction ofa radiolabeled agonist withcardiac muscarinic choliner-gic receptors, 570

Hardy, K. J., see Mihaly, G. W.,441

Harvey, J. A., see Schindler, C.W., 639

Heart, effect of prostaglandin in-

teraction with angiotensin II

on adrenergic transmissionin (dogs), 676

Heart rateeffects of epinephrine, a-meth-

ylnorepinephrine and a-epi-nephrine on (rats), 484

effects of LY53857 (rats), 327effects of norepinephrine and

epinephrine on (rats), 254effects of opioids and nicotine

on (dogs), 302

Heisler, S., see Reisine, T., 107Heldsinger, A. A., see Vinik, A. I.,

115

Hemrick-Luecke, S. K., seeFuller, R. W., 354

Henderson, F., see Fiekers, J. F.,308

Hepatocytes, isolated, metabo-

lism of aminopyrine by

(rats), 687Hepatotoxicity, styrene 7,8-ox-

ide-induced, role of epoxidehydrolase in prevention of(rats), 491

Herling, S., see Shannon, H. E.,

160

Herling, S., Solomon, R. E. andWoods, J. H.: Discriminative

stimulus effects of dextror-

phan in (pigeons), 723

Hermsmeyer, K., Trapani, A.,Abel, P. W. and Worcel, M.:Effect of hydralazine on ten-sion and membrane potentialin the rat caudal artery, 322

Hernandez, L., Parada, M. and

Hoebel, B. G.: Amphetamine-induced hyperphagia andobesity caused by intraven-

tricular or lateral hypothala-mic injections in rats, 524

Hexamethonium, effect of ached-ule-controlled responding of

nicotine (monkeys), 154Hexobarbital, in vivo metabolism,

correlation with antipyrine(rats),459

Hindquarters, perfused, vascularresponses in (rats), 621

Histamine, inhibitory effects onserotonin-containing neu-rons in dorsal raphe nucleus(rats), 517

Hoebel, B. G., see Hernandez, L.,524

Hoffman, B. F., see Dangman, K.H., 578

Holden, D. A., see Weichman, B.M., 700

Hollister, A. S., see Tung, C.-S.,484

Holohan, P. D., see Kasher, J. S.,122

Holsapple, M. P., Munson, A. E.,Munson, J. A. and Bick, P.H.: Suppression of cell-me-diated immunocompetenceafter subchronic exposure todiethylstilbestrol in female

B6C3F1 mice, 130Hook, B. G., see Romson, J. L.,

288Hook, J. B., see Rush, G. F., 658

Hook, J. B., see Stroo, W. E., 55Horita, A., see Yamawaki, S., 383Hormone (see also specific name)

antidiuretic, effects on urinary

prostaglandin excretion(rats), 215

Hormone biosynthesis, steroid,effects of /3-naphthoflavone

on (rats), 248

Hoshino, E., see Sakai, K., 220Howerton, T. C., O’Connor, M. F.

and Collins, A. C.: Lipid sol-

ubility is correlated with hyp-notic and hypothermic re-sponses of long-sleep (LS)

and short-sleep (55) to var-ious depressant drugs, 389

Huerta, F. I., see Sharma, A. D.,716

Hurwitz, A. and Fischer, H. R.:Narcotic effects on hepaticdisposition of sulfobromo-

phthalein in rats, 68Hydralazine

effect on tension and mem-brane potential in caudal ar-tery (rats), 322

hypotensive and diuretic ac-tions of (rats), 472

5-Hydroxytryptamine, effect on[3HJspiperone binding to cor-

tical membranes (rats), 429Hynes, M. D., III, see Fuller, R.

W., 354

Hyperphagia, amphetamine-in-duced, role of lateral hypo-thalamus injections (rats),524

Hypertension, neurogenic, nor-

epinephrine release during(rats), 187

Hypotensionfentanyl-induced, antagonism

by N-allylnormetazocine(dogs), 302

induced by diltiazem and hy-

dralazine (rats), 472

Hypothalamus, lateral, amphet-amine-induced obesitycaused by injections in (rats),524

lacopino, V. J., Fitzpatrick, T. M.,Ramwell, P. W., Rose, J. C.and Kot, P. A.: Cardiovascu-

lar responses to leukotriene

C4 in the rat, 244Ileum, release of substance P from

enteric nervous system of(guinea pigs), 365

Immunocompetence, cell-medi-

ated, effect of diethylstilbes-trol on (mice), 130

Immunosuppression, diethylstil-bestrol-induced (mice), 130

Indocyanine green, effect on pul-monary removal of prosta-glandin E1 in vivo (rabbits),531

Indomethacin, inhibition of cal-cium transport in liver by

(hamsters, rats), 84Interferons, human, alpha and

beta, pharmacokinetics(rats), 9

1983 Index 801

Intestine, small, motility effectsof j3-endorphin and its me-tabolites on (dogs), 499

Ipindole, effect on I3Hlspiperonebinding to cortical mem-branes (rats), 429

3-Isobutylmethylxanthine, neu-

ropharmacology of (rats), 1Isoproterenol

chronotropic and inotropic ac-tivity in atria (guinea pigs,dogs), 267

effect on 02 saturation in veins(dogs), 333

-induced relaxation in tracheal

smooth muscle, effect of

methacholine on (dogs), 694stimulation of adenylate cy-

clase by (mice), 551stimulation of cyclic AMP for-

mation and adrenocortico-tropin hormone secretion(mice), 107

Jacobson, K. A., see Rosenkranz,R. P., 267

Jaffe, B. M., see Baron, S. A., 365Jager, L. P., see Kannan, M. S.,

706

Jauhohen, P., see Nomura, F., 78Jejunum, effect of surfactants on

enteric neurons of (rats), 538Joeres, R. P., see van der Graaff,

M., 459Johnson, M. D., Smith, P. G.,

Mills, E. and Schanberg, S.M.: Paradoxical elevation ofsympathetic activity during

catecholamine infusion inrats, 254

Jones, D. B., see Mihaly, G. W.,441

Kajiwara, A., see Ohizumi, Y., 199Kalivas, P. W., Widerl#{246}v, E.,

Stanley, D., Breese, G. andPrange, A. J., Jr.: Enkephalinaction on the mesolimbic sys-tam: A dopamine-dependentand a dopamine-independentincrease in locomotor activ-ity, 229

Kamal, L. A., Arbilla, S., Galzin,A.-M. and Langer, S. Z.: Am-phetamine inhibits the elec-trically evoked release of [3H]dopamine from slices of therabbit caudate, 446

Kamen, B. A., see Krakower, G.R., 633

Kanamycin, effect on membranephosphoinositide metabolism(rats), 415

Kannan, M. S., Jager, L. P., Dan-

iel, E. E. and Garfield, R. E.:Effects of 4-aminopyridineand tetraethylammoniumchloride on the electrical ac-tivity and cable properties ofcanine tracheal smooth mus-cle, 706

Kaojarern, S., see Brater, D. G.,92

Kaplan, H. R., see Weishaar, R.E., 767

Kasher, J. S., Holohan, P. D. andRoss, C. R.: Na� gradient-de-pendent p-aminohippurate

(PAH) transport in rat baso-lateral membrane vesicles,122

Katims, J. J., Annau, Z. and Sny-der, S. H.: Interactions in thebehavioral effects of meth-ylxanthines and adenosinederivatives, 167

Kendall, D. A. and Nahorski, S.

R.: Temperature-dependent5-hydroxytryptamine (5-HT)-sensitive I3Hjspiperonebinding to rat cortical mem-branes: Regulation by gus-nine nucleotide and antide-pressant treatment, 429

Ketamine, effects of food depri-vation on oral self-adminis-tration of (monkeys), 28

Ketazocine, diuretic effects (rats),35

Kidneyp-aminohippurate transport in

(rats), 122effect of anesthesia on elimi-

nation of cimetidine in(sheep), 441

effects of nonesterified fattyacids on organic ion trans-

port in (rabbits), 55formation of methotrexate po-

lyglutamate in (rats), 633impaired transport of p-amino-

hippuric acid by (rats), 409isolated perfused, role of cal-

cium in interaction of alphaand beta adrenoceptor-medi-ated renin release in (rab-bits), 144

nephrectomy, effects on phar-macokinetics of interferons(rats), 9

UDP-glucuronyltransferase ac-

tivity, sex differences in

(rats), 658Kidney failure, induced by uranyl

nitrate (rats), 295

Killian, A., see Chang, K.-J., 403Kinetics (see also Pharmacoki-

netics)

of a-bungarotoxin binding toacetylcholine receptors(rats), 340

Kitabgi, P., see Checler, F., 743Klevans, L., see Rosenkranz, R.

P., 267Koepke, J. P., Grignolo, A., Light,

K. C. and Obrist, P. A.: Cen-tral beta adrenoceptor media-tion of the antinatriuretic re-sponse to behavioral stress inconscious dogs, 73

Kolis, S. J., Williams, T. H.,Mowles, T. F., Burghardt, B.,Toome, V. and Schwartz, M.A.: Metabolites ofan antipsy-chotic chiral pyrroloisoqui-noline and their effect onprolactin secretion in the rat,

652

Kot, P. A., see lacopino, V. J., 244Kousvelari, E. E., Kusiak, J. W.,

Hand, A. R., Pitha, J. andBaum, B. J.: Bromoacetylal-prenololmenthane: A potentirreversible antagonist of

beta adrenergic elicited pro-tein exocytosis in rat parotidcells, 238

Koutouzov, S., see Marchi, P., 415Krakower, G. R. and Kamen, B.

A.: In situ methotrexate po-lyglutamate formation in rat

tissues, 633

Kramer, R. A. and Boyd, M. R.:Nephrotoxicity of 1-(2-chlo-roethyl)- 3 -(trans- 4 -methyl-cyclohexyl) - 1 - nitrosourea(MeCCNU) in the Fischer344 rat, 409

Krasny, H. C., see Good, S. S., 644Krieger, E. M., see Granata, A. R.,

187

Ku, T. W., see Weichman, B. M.,700

Kuhn, C. M., see McMillian, M.K., 181

Kurz, K. D., see Cohen, M. L., 327Kusachi, S., Thompson, R. D. and

Olsson, R. A.: Ligand selec-tivity of dog coronary adeno-sine receptor resembles that

of adenylate cyclase stimula-tory (Re) receptors, 316

Kusiak, j. W., see Kousvelari, E.E., 238

Lai, H., see Yamawaki, S., 383Lakoski, J. M. and Aghajanian,

G. K.: Effects of histamine,H�- and H2-receptor antago-fists on the activity of sero-

tonergic neurons in the dor-sal raphe nucleus, 517

Langer, S. Z., see Granata, A. R.,187

Langer, S. Z., see Kamal, L. A.,446

Lanier, S. M. and Malik, K. U.:

Facilitation of adrenergic

transmission in the canine

heart by intracoronary infu-sion of angiotensin H: Effect

of prostaglandin synthesis

inhibition, 676

Lau, H. S. H., Shih, L.-J. and

Smith, D. E.: Effect of pro-

benecid on the dose response

relationship ofbumetanide atsteady state, 51

Lauterburg, B. H., see Adams, J.D., Jr., 749

Leander, J. D. and Zimmerman,D. M.: Effects of picenadoland its agonist and antago-nist isomers on schedule-con-

trolled behavior, 671Leander, J. D.: Further study of

kappa opioids on increasedurination, 35

Leukotriene C4 , cardiovascularresponses to (rats), 244

Levoxadrol, comparison with dex-oxadrol to produce dextror-phan-like discriminative ef-fects (pigeons), 723

Lidocaine, effect on barium-in-

duced abnormal automaticity(dogs), 578

Lieber, C. S., see Nomura, F., 78Light, K. C., see Koepke, J. P., 73Lincomycin, neuromuscular ef-

fects (snakes), 308Lisuride, behavioral effects (rats),

557

Livereffect of morphine on disposi-

tion of sulfobromophthaleinin (rats), 68

formation of methotrexate po-lyglutamates in (rats), 633

inhibition by nonsteroidal anti-

inflammatory drugs of cal-

cium transport in (hamsters,rats), 84

ontogeny of adrenoceptors in(rats), 181

perfused, ability of epoxide hy-

drolase to protect against sty-

rene 7,8-oxide-induced tox-icity in (rats), 491

Locomotor activity

effect of LY141865 on (rats),354

effects ofopiates on (mice), 466in nucleus accumbens, effect of

D-Ala2 Meta -enkephalinam-ide on (rats), 229

Lorenz, R. R., see Vanhoutte, P.M., 613

4R,5S,6Z-2-nor-LTD1 , leukotri-ene antagonist, antagonismof pulmonary effects of pep-tidoleukotrienes by (guinea

pigs), 700Lucchesi, B. R., see Romson, J.

L., 288Lucchesi, B. R., see Schumacher,

W. A., 790LY141865, behavioral effects

(rats), 354LY53857, effect on heart rate and

blood pressure (rats), 327Lysergic acid diethylamide, he-

havioral effects (rats), 557

Macdonald, R. L., see McLean, M.J., 779

Macdonald, R. L., see Werz, M.A., 394

Maitotoxin, effect on tissue Ca

content in vas deferens(guinea pigs), 199

Malik, K. U., see Lanier, S. M.,676

Marafino, B. J., Jr., see Toka-zewski-Chen, S. A., 9

Marcais-Collado, H., Chaillet, P.and Costentin, J.: Inhibitionof the spontaneous climbingbehavior elicited in mice by

opiates, 466Marche, P., Koutouzov, S. and

Girard, A.: Impairment of

membrane phosphoinositidemetabolism by aminoglyco-side antibiotics: Streptomy-

cm, amikacin, kanamycin, di-

bekacin, gentamicin and neo-mycin, 415

Marshall, I. G., see Fiekers, J. F.,308

802 Index Vol. 227

Martin, M. W., see Harden, T. K.,570

Martin, W. R., see Wu, K. M., 302Masse, T. and Mittag, T. W.: Het-

erogeneity of acetylcholinereceptors: Different forms ofreceptor distinguished by a-bungarotoxin kinetics and byantibody binding properties,

340Matsumoto, M. and Riker, W. K.:

Synaptic transmission in low

extracellular calcium is pre-served by 3,4-diaminopyri-dine, 16

Mattammal, M. B., see Zenser, T.V., 139, 545

Mayer, S. E., see Torphy, T. J.,694

McCarthy, L. E., see Doherty, P.

A., 508McCown, T. J., see Frye, G. D.,

663

McLean, M. J. and Macdonald,R. L.: Multiple actions ofphenytoin on mouse spinal

cord neurons in cell culture,779

McMillian, M. K., Schanberg, S.M. and Kuhn, C. M.: Ontog-eny of rat hepatic adrenocep-

tors, 181Mecamylamine

effect on heart rate and bloodpressure (dogs), 302

effect on schedule-controlledresponding of nicotine (mon-

keys), 154Meclofenamate, inhibition of cal-

cium transport in liver by(hamsters, rats), 84

Meeker, R. B., see Harden, T. K.,570

Meffin, P. J., Zilm, D. M. andVeenendaal, J. R.: A renalmechanism for the clofibricacid-prohenecid interaction,

739

Meffin, P. J., Zilm, D. M. andVeenendaal, J. R.: Reducedclofibric acid clearance in

renal dysfunction is due to afutile cycle, 732

Melatonin, psychopharmacologi-

cal effects (mice and rats),587

Melmon, K. L., see Rosenkranz,R. P., 267

Mepyramine, antagonism of his-tamine-stimulated calcium

activity by (guinea pigs), 1153-Mercaptopropionic acid-in-

duced convulsions, antago-nism by melatonin (mice,rats), 587

Mesolimbic dopamine system,modulation by enkephalin

(rats), 229Metabolism

aminopyrine, effect of ethanol

on (rats), 687of benzidine (rabbits), 545

in vivo, of hexobarbital and an-tipyrine, correlation between

(rats), 459of 5’ -deoxy-5-fluorouridine

(rats), 174

of �f-endorphin (dogs), 499of ethanol, effect of alcohol con-

sumption on (baboons), 78of membrane phosphoinositide,

impairment by aminoglyco-side antibiotics (rats), 415

of norepinephrine (rats), 1, 187peroxidase, of carcinogens

(rams, dogs, rabbits), 139renal, lipid, effect of penicillin

(rabbits), 55stereoselective, of pyrroloiso-

quinoline (rats), 652steroid, effect of �i-naphthofla-

vone (rats), 248Methacholine

effect on isoproterenol-induced

relaxation, cyclic AMP accu-mulation and protein kinaseactivation in tracheal smooth

muscle (dogs), 694

-induced coronary vasocon-striction, effects of nicorandiland nitroglycerin on (pigs),220

Methadone, role in behavioral ef-fects of picenadol (pigeons),

671

Methimazole, inhibition of pros-taglandin H synthase-acti-vated benzidine binding by(rabbits), 545

Methionine, synthetase, hepatic,

role in regulation of tetrahy-drofolate-dependent metabo-

lism (monkeys), 349Methotrexate, formation of poly-

glutamates in situ (rats), 633

2 - n - propyl - Methylenediox-yindene, relaxant effect onaortic rings (rabbits), 767

a-Methylepinephrine, cardiovas-cular effects of (rats), 484

N-Methyllevonantradol, respira-

tory and cardiovascular de-

pressant effects of (cats), 508a-Methylnorepinephrine, effect

on blood pressure and heartrate (rats), 484

Methylxanthinesbehavioral effects (mice), 167

effects on norepinephrine sys-

tems (rats), 1Methyprylon, hypnotic and hy-

pothermic effects (mice), 389Mianserin, effect on [3Hjspipe-

rone binding to cortical mem-branes (rats), 429

Microsomes, ovarian, effects of $-naphthoflavone on steroidhormone biosynthesis andmetabolism in (rats), 248

Mihaly, G. W., Jones, D. B., Mor-

gan, D. J., Ching, M. S.,Webster, L. K., Smallwood,R. A. and Hardy, K. J.: Pla-cental transfer and renalelimination of cimetidine inmaternal and fetal sheep, 441

Miller, R. J., see Forsberg, E. J.,755

Mills, E., see Johnson, M. D., 254Minneman, K. P.: Binding prop-

erties of alpha-i adrenergicreceptors in rat cerebral cor-

tax: Similarity to smoothmuscle, 605

Mitchell, J. R., see Adams, J. D.,Jr., 749

Mitochondrial uncoupling, effectof methylenedioxyindenes on(rabbits), 767

Mittag, T. W., see Masse, T., 340MK447, inhibition of prostaglan-

din H synthase-activatedbenzidine binding by (rab-bits), 545

Mokler, D. J., Commissaris, R. L.,Warner, M. R. and Rech, R.H.: Blockade of the behav-ioral effects of lysergic acid

diethylamide, 2,5-dimeth-oxy-4-methylamphetamine,quipazine and lisuride by 5-hydroxytryptamine antago-nists, 557

Molinoff, P. B., see Rabin, R. A.,

551

Morgan, D. J., see Mihaly, G. W.,441

Morgan, W. W., see Proll, M. A.,627

Moroni, F., Tanganelli, S., Anto-nelli, T., Carla, V., Bianchi,

C. and Beani, L.: Modulationof cortical acetylcholine and-y-aminobutyric acid release

in freely moving guinea pigs:Effects ofclonidine and otheradrenergic drugs, 435

Morphiceptin

effect on ganglion action poten-tials (mice), 394

-induced bradycardia and anal-gesia (rats, mice, guinea

pigs), 403

Morphineantagonism of diuretic effects

ofopioids by (rats), 35

effect on classical conditioningof nictitating membrane re-sponse (rabbits), 639

effect on hepatic disposition of

sulfobromophthalein (rats),68

-induced antinociception, an-tagonism by naloxone (rats),42

inhibition of gastrointestinal

transit by (mice), 22

-like activities of morphiceptinanalogs (rats, mice, guineapigs), 403

tolerance, relationship of dose(chicks), 376

Mowles, T. F., see Kolis, S. J., 652Munson, A. E., see Holsapple, M.

P., 130Munson, J. A., see Holsapple, M.

P., 130Muramatsu, I., Oshita, M. and

Yamanaka, K.: Selective at-

pha-2 blocking action of DG-5128 in the dog mesentericartery and rat vas deferens,194

Muramatsu, I., see Yokotani, K.,478

Muscimol, suppression of with-drawal-related audiogenicseizures by (rats), 663

Muscle

smooth, airway, effects of 4-

aminopyridine and tetraeth-

ylammonium chloride on

electrical activity and cableproperties of (dogs), 706

smooth, airway, functional an-tagonism in (dogs), 694

smooth, of myenteric plexus, ef-

fect of surfactants on (rats),538

smooth, vascular, effects buflo-medil on (dogs), 613

Myenteric plexusofjejunum, effect of benzalkon-

ium chloride on number of

ganglion cells in (rats), 538release of substance P from

(guinea pigs), 365

Nabilone, respiratory and cardio-vascular depressant effects of

(cats), 508

Nagao, T., see Narita, H., 472Nahorski, S. R., see Kendall, D.

A., 429Nalorphine, behavioral effects

(monkeys), 563Naloxone

antagonism of behavioral ef-fects of picenadol (pigeons),671

antagonism of discriminative

stimulus effects of nalor-

phine by (monkeys), 563antagonism of diuretic effects

of opioids by (rats), 35

antagonism of foot shock- and

morphine-induced antinoci-ception by (rats), 42

antagonism of increase in loco-motor activity in nucleus ac-cumubens by (rats), 229

effect on heart rate and bloodpressure (dogs), 302

Naproxen, inhibition of calciumtransport in liver by (ham-stars, rats), 84

Naray-Fejes-Toth, A., see Fejes-Toth, G., 215

Narita, H., Nagao, T., Yabana, H.and Yamaguchi, I.: Hypoten-sive and diuretic actions ofdiltiazem in spontaneouslyhypertensive and Wistar

Kyoto rats, 472Natriuresis, induced by bumetan-

ide, effect of probenecid on(dogs), 51

neomycin, effect on membranephosphoinositide metabolism(rats), 415

Nephrotoxicity, of 1-(2-chloro-ethyl) - 3 - (trans - 4 - methyl-cyclohexyl) - 1 - nitrosourea(rats), 409

Nervous system

central, histamine electrophys-iology in (rats), 517

enteric, release of substance Pfrom (guinea pigs), 365

sympathetic, effects on bethan-echol-induced elevation ofgastric acid secretion andmucosal blood flow (rats),478

1983 Index 803

sympathetic, role in mainte-

nance of elevated blood pres-sure (rats), 254

Neuromuscular junction

effects of 4-aminopyridine and3,4-diaminopyridine on

transmitter release at (rats),260

effects of clindamycin and lin-comycin on end-plate cur-rents and quantal content at(snakes), 308

Neurons, serotonergic, in dorsalraphe nucleus, inhibition byhistamine (rats), 517

Neurotensin, [D-TYR�] and [D-PHE11], susceptibility to deg-radation by brain peptidases(rats), 743

Neurotoxicity, of melatonin(mice, rats), 587

Neurotransmission, sympathetic,

during neurogenic hyperten-

sion (rats), 187Newton, J. F., see Rush, G. F., 658Nicorandil, cardiovascular and

vasospasmolytic effects(pigs), 220

Nicotine

behavioral effects of (mon-keys), 154

effect on heart rate and blood

pressure (dogs), 302Nictitating membrane response,

effect of morphine on classi-cal conditioning of (rabbits),

639Nipecotic acid, effect on -y-ami-

nobutyric acid uptake (rats),627

Nitrous oxide, inhibition of me-

thionine synthetase by (mon-

keys), 349

Nitroglycerin, cardiovascular and

vasospasmolytic effects(pigs), 220

Nomura, F., Pikkarainen, P. H.,

Jauhonen, P., Arai, M., Gor-don, E. R., Baraona, E. andLieber, C. S.: Effect ofethanol administration on

the metabolism of ethanol in

baboons, 78Norepinephrine

-constricted resistance vessels

in hindquarters, effects of

vasodilators on (rats), 621

coronary sinus output, effect of

angiotensin II on (dogs), 676effect on release of acetylcho-

line and -y-aminobutyric acidfrom brain (guinea pigs), 435

effect on systolic blood pressureand heart rate (rats), 254

-induced coronary vasocon-

striction, effects of nicorandil

and nitroglycerin on (pigs),220

influence of prazosin and yo-

himbe on contractile re-

sponse of aorta to (rabbits),60

metabolism, effect of meth-ylxanthine on (rats), 1

release during neurogenic hy-potension (rats), 187

release from vas deferens, effectof maitotoxin on (guineapigs), 199

[3H]Norepinephrine, release inmesenteric artery, effects of

DG-5128 on (dogs, rats), 194

Norton, S., see Schmidt, M. B.,376

Nucleus accumbens, effect of D-

Ala2- Met5 -enkephalinamideon locomotor activity in

(rats), 229

Oates, J. A., see Tung, C.-S., 484Obesity, amphetamine-induced,

role of lateral hypothalamusinjections (rats), 524

Obrist, P. A., see Koepke, J. P.,73

O’Connor, M. F., see Howerton,T. C., 389

O’Donnell, M., see Rosenkranz,R. P., 267

Ohizumi, Y., Kajiwara, A. andYasumoto, T.: Excitatory ef-fect of the most potent ma-rine toxin, maitotoxin, on theguinea-pig vas deferens, 199

Olsson, R. A., see Kusachi, S., 316Ontogeny, of hepatic adrenocep-

tors (rats), 181Opiates, inhibition of sponta-

neous climbing behavior by

(mice), 466Opgenorth, T. J. and Zehr, J. E.:

Role of calcium in the inter-action of alpha and beta ad-renoceptor-mediated reninrelease in isolated, constantpressure perfused rabbit kid-neys, 144

Opioidsdiscriminative effects (pi-

geons), 723kappa, diuretic effects (rats), 35

Ortiz, E., see Fuhrman-Lane, C.,248

Osborn, R. R., see Weichman, B.M., 700

Oshita, M., see Muramatsu, I., 194Oxilorphan, diuretic effects

(rats), 35

I3H]Oxotremorine, interactionwith cardiac muscarinic re-ceptors (rats), 570

Oxprenolol, effect on antinatri-uretic response to behavioral

stress (dogs), 73

Palmier, M. 0., see Zenser, T. V.,139

Papaverine, relaxant effects on

aortic rings (rabbits), 767Parada, M., see Hernandez, L.,

524Paraquat, effect on hepatic and

arterial glutathione and glu-

tathione disulfide (rats), 749Parsons, R. L., see Fiekers, J. F.,

308

Payne, R., see Awad, R., 60Pearson, D., see Fuller, R. W., 354Penicillin, effect on renal, lipid

metabolism (rabbits), 55

Pentazocine, d- and 1-, effects onfoot shock-induced antinoci-

ception (rats), 42Pentobarbital, hypnotic and hy-

pothermic effects (mice), 389Pentobarbitone-induced sleep,

potentiation by melatonin

(mice, rats), 587

Pentylenetetrazole-induced con-vulsions, antagonism by me-latonin (mice, rats), 587

Peptidase, brain, effect on degra-

dation of neurotensin ana-logs (rats), 743

Peptides, opioid, effects on gan-

glion action potentials

(mice), 394Peptidoleukotrienes, pulmonary

effects (guinea pigs), 700Peace, G. and Adler-Graschinsky,

E.: Comparison of the effectsoff.�-phenylethylamine and d-amphetamine on rat isolated

atria, 205

Pharmacokinetics, of l-proprano-lol (rats), 369

Pharmacology

of catecholamine conjugates

(guinea pigs, dogs), 267

of histamine in the central ner-

vous system (rats), 517of a-methylepinephrine (rats),

484

Pharmacodynamics

of bumetanide (dogs), 51

of catecholamine conjugates

(guinea pigs, dogs), 267

of diuretic effects of amino-

phylline and azetazolamine

alone and combined with fu-

rosemide (man), 92Pharmacokinetics

of benzodiazepines (cats), 98of bumetanide (dogs), 51

of 5-fluorouracil and 5’ -deoxy-

5-fluorouridine (rats), 174of human interferon, effects of

nephrectomy on (rats), 9

of propranolol (dogs), 360

of l-propranolol, effect of ura-

nyl nitrate on (rats), 295

Phenidone, inhibition of prosta-glandin H synthase-activated

benzidine binding by (rab-

bits), 545

Phenobarbital, prenatal effects

(rats), 274Phenoxybenzamine, effect on a!-

p/ia- 1 adrenergic receptorbinding sites in brain (rats),

605

Phentolamine, effect on [3H]pra-

zosin binding in aorta (rab-

bits), 60

Phenylephrine-induced contrac-

tions in caudal artery, effect

of hydralazine (rats), 322

�3-Phenylethylamine, effect onisolated atria, comparisonwith d-amphetamine (rats),

205Phenylisopropyladenosine, be-

havioral interactions with

xanthines (mice), 167Phenytoin, anticonvulsant ac-

tions of (mice), 779

Picenadol, behavioral effects (pi-

geons), 671

Pikkarainen, P. H., see Nomura,F., 78

Pitha, J., see Kousvelari, E. E.,238

Pitt, B. R., Forder, J. R. and Gil-

lis, C. N.: Drug-induced im-

pairment of pulmonary [3Hj

prostaglandin E1 removal in

vivo, 531PLO17, analgesic activity of (rats,

mice, guinea pigs), 403Placental transfer, of cimetidine

(sheep), 441Platelet aggregation, effect of da-

zoxiben on (dogs), 790Plunkett, L. M. and Tackett, R.

L.: Central alpha receptors

and their role in digoxin car-diotoxicity, 683

Polyglutamates, methotrexate,

formation in tissues in situ(rats), 633

Porreca, F. and Burks, T. F.: Thespinal cord as a site of opioid

effects on gastrointestinaltransit in the mouse, 22

Potassium

-constricted resistance vessels

in hindquarters, effects ofvasodilators on (rats), 621

-induced contractions in caudal

artery, effect of hydralazine

(rats), 322

Potassium conductance, in tra-cheal smooth muscle, effectoftetraethylammonium chlo-ride on (dogs), 706

Potentials (see specific name)action, calcium-dependent in

spinal cord neurons, effect of

phenytoin on repetitive firingof (mice), 779

action in ganglion, calcium-de-pendent, effects of opioid

peptides on (mice), 394

end-plate, in neuromuscularjunction, effects of 4-amino-pyridine and 3,4-diaminopyr-

idine on (rats), 260

Practolol, effect on 02 saturation

in veins (dogs), 333

Prange, A. J., Jr., see Kalivas, P.W., 229

Prazosinantagonism of stimulating ef-

fects of clonidine and norepi-

nephrine on release of acetyl-choline and -y-aminobutyricacid from brain by (guinea

pigs), 435

effect on digoxin cardiotoxicity

(dogs), 683relaxant effect on aortic rings

(rabbits), 767Pressure, systemic and pulmo-

nary arterial, effect of leuko-triene C4 on (rats), 244

Probenecid

-clofibric acid interaction, arenal mechanism for (rab-

bits), 739

effect on dose-response rela-tionship of bumetanide

(dogs), 51

effect on pulmonary removal of

prostaglandin E1 in vivo (rab-

804 Index Vol. 227

bits), 531

Proll, M. A. and Morgan, W. W.:

Use of -y-aminobutyric acid(GABA)-transaminase in-

hibitors and a GABA uptakeinhibitor to investigate the

influence of GABA neuronson dopamine-containingamacrine cells of the rat ret-

ma, 627

Propranololchronic, stereoselectivity

(dogs), 360effect on antinatriuretic re-

sponse to behavioral stress(dogs), 73

effect on 02 saturation in veins

(dogs), 333l-Propranolol, alterations in se-

rum protein binding and

pharmacokinetics of (rats),

369

Propylthiouracil, inhibition ofprostaglandin H synthase-activated benzidine binding

by (rabbits), 545

Prostacyclin, potentiation by

aminophylline in experimen-tal thrombosis (dogs), 288

Prostaglandin, E1, pulmonary,

drug-induced impairment of

removal in vivo (rabbits), 531Prostaglandin H synthase

-catalyzed activation of benzi-

dine, a model (rabbits), 545

-catalyzed binding of carcino-

gens, comparative effects

(rams, dogs, rabbits), 139

Prostaglandinsinteraction with angiotensin II,

effect on adrenergic trans-

mission in heart (dogs), 676

renal, effect of xanthines on ex-

cretion of (rats), 600Protein kinase, cyclic AMP-de-

pendent, activation in tra-

cheal smooth muscle, effectof methacholine on (dogs),

694Proxorphan, diuretic effects

(rats), 35Purkinje fibers, cardiac, antiar-

rhythmic effects of ethmozinin (dogs), 578

Pyrazole, effect on time course oftolerance to ethanol (mice),150

Pyrroloisoquinoline

stereoselective metabolism

(rats), 652

Quade, M., see Weishaar, R. E.,

767Quipazine

behaviorial effects (rats), 557-induced corticosterone eleva-

tions, inhibition by LY53857

(rats), 327

Rabin, R. A. and Molinoff, P. B.:Multiple sites of action ofethanol on adenylate cyclase,551

Ramwell, P. W., see lacopino, V.J., 244

Raphe nucleus, dorsal, inhibitory

effects of histamine on sero-tonin-containing neurons in(rats), 517

Receptorsacetylcholine, heterogeneity

(rats), 340adenosine, effect on coronary

artery relaxation (dogs), 316adenosine, role in behavioral

effects of alkylxanthines(mice), 167

alpha adrenergic subtypes, ef-fect on calcium influx/effluxin aorta (rabbits), 60

alpha, central, role in digoxincardiotoxicity (dogs), 683

alpha- 1 adrenergic, in cerebralcortex, binding properties(rats), 605

alpha and beta adrenergic, ef-fect on ventricular defibrilla-

tion (rats), 716beta adrenergic, role in adreno-

corticotropin hormone secre-tion (mice), 107

beta adrenoceptor, mediation of

antinatriuretic response to

behavioral stress by (dogs),

73

beta-i adrenergic, role in het-erogeneity of 02 saturation

(dogs), 333dopamine, in striatum, compar-

ison of sites labeled by [3HJ-S-sulpiride and [3H]spipe-

rone (rats, rabbits), 592H1 and H2, effect on seroto-

nergic neurons in dorsalraphe nucleus (rats), 517

histamine H1 and H2, in oxyntic

cells, effect on calcium activ-ity (guinea pigs), 115

mu and delta, mediation ofopioid peptide reduction of

calcium-dependent actionpotentials (mice), 394

muscarinic, in heart, agonistbinding on (rats), 570

opiate, in ventral tegmental

area, effect of D-Ala2-Met5-enkephalinamide on (rats),229

Rech, R. H., see Mokler, D. J., 557Reisine, T. and Heisler, S.: De-

sensitization of beta adrener-gic receptors linked to adren-ocorticotropin secretion, 107

Renal dysfunction, effect of ura-nyl nitrate on reduced clofi-bric clearance in (rabbits),

732

Renin, release in kidneys, a’pha

and beta adrenoceptor-medi-ated, role of calcium (rab-bits), 144

Resistance vessels, of perfusedhindquarters, vasoconstric-

tor responses of (rats), 621Resperine, antagonism of�9-phen-

ylethylamine effects on atria

by (rats), 205

Retina, effect of y-aminobutyric

on dopamine synthesis in

(rats), 627

Rice, J. R., see Zenser, T. V., 545Rietow, M. G., see Torphy, T. J.,

694Riker, W. K., see Matsumoto, M.,

16

Rimele, T. J., see Vanhoutte, P.M., 613

Rinard, G. A., see Torphy, T. J.,694

Roach, A. G., Doxey, J. C., Stra-chan, D. A. and Cavero, I.:Sleeping times evoked by al-p1w adrenoceptor agonists in

2-day-old chicks: An experi-mental model to evaluate fulland partial agonists at cen-tral atpha-2 adrenoceptors,421

Robertson, D., see Tung, C-S.,484

Romson, J. L., Hook, B. G. andLucchesi, B. R.: Potentiation

of the antithrombotic effectof prostacyclin by simulta-

neous administration of ami-

nophylline in a canine model

of coronary artery thrombo-

sis, 288Rosenkranz, R. P., Jacobson, K.

A., Verlander, M. S., Kle-vans, L., O’Donnell, M.,

Goodman, M. and Melmon,K. L.: Conjugates of cate-

cholamines. IV. In vitro andin vivo pharmacological ac-

tivity of monodisperse oligo-

peptide conjugates, 267

Roth, R. H., see Galloway, M. P.,

Rose, J. C., see lacopino, V. J.,244

Ross, C. R., see Kasher, J. S., 122Rush, G. F., Newton, J. F. and

Hook, J. B.: Sex differencesin the excretion of glucuro-

nide conjugates: The role ofintrarenal glucuronidation,658

Rustum, Y., see Au, J. L.-S., 174

Sakai, K., Akima, M., Shiraki, Y.

and Hoshino, E.: Effects of anew antianginal agent, nicor-

andil, on the cardiovascularsystem of the miniature pig:

With special reference to cor-

onary vasospasm, 220

Saturation, of 02 in veins, role of

beta- 1 adrenergic receptors inheterogeneity of (dogs), 333

Schanberg, S. M., see Johnson, M.D., 254

Schanberg, S. M., see McMillian,M.K., 181

Schenden, J. A., see Weishaar, R.E., 767

Schindler, C. W., Gormezano, I.

and Harvey, J. A.: Effect of

morphine on acquisition ofthe classically conditionednictitating membrane re-

sponse of the rabbit, 639

Schmidt, M. B. and Norton, S.:

Relationship of dose to mor-

phine tolerance in the chick

embryo, 376

Schoemaker, H., see Davis, T. P.,499

Schumacher, W. A. and Lucchesi,

B. R.: Effect of the throm-boxane synthetase inhibitorUK-37,248 (dazoxiben) upon

platelet aggregation, coro-nary artery thrombosis andvascular reactivity, 790

Schwartz, M. A., see Kolis, S. J.,652

Secobarbital, hypnotic and hypo-

thermic effects (mice), 389

Secretionisoproterenol-induced from pa-

rotid cells, effect of bromo-

acetyl-prenololmenthane on

(rats), 238of adrenocorticotropin hor-

mone, role of beta adrengericreceptors on (mice), 107

of gastric acid, effects of sym-

pathetic nervous system on

(rats), 478

of sulfobromophthalein into

bile, effect of morphine(rats), 68

renal, of clofibric acid glucuro-nide, inhibition by probene-cid (rabbits), 739

Seizures, audiogenic, withdrawal-related, suppression by �y-

aminobutyric acid agonists

(rats), 663

Sellers, E. M., see Arendt, R. M.,98

Sensitivity, of ethanol, genetic ef-

fects (mice), 389

Serotonin, regulation of release

from intestinal enterochro-

maffin cells (rabbits), 755Serum protein binding

of l-propranolol, alterations in

(rats), 369

of l-propranolol in renal failure

(rats), 295Sex differences, in renal and he-

patic microsomal glucuroni-dation (rats), 658

Shader, R. I., see Arendt, R. M.,98

Shannon, H. E. and Herling, S.:

Discriminative stimulus ef-fects of diazepam in rats: Ev-

idence for a maximal effect,160

Sharma, A. D., Waxman, M. B.

and Huerta, F. I.: Effect of

adrenergic stimulation and

blockade on ventricular defi-

brillation in the rat, 716

Shen, D. D., see Terao, N., 295,369

Shih, L.-J., see Lau, H. S. H., 51Shiraki, Y., see Sakai, K., 220

Shiverick, K. T., see Fuhrman-Lane, C., 248

Skoglund, M. L., see Vinik, A. I.,115

Sleep, induced by pentobarbitoneand barbitone, potentiation

by melatonin (mice, rats),

587

Sleeping time, increase, effects of

1983 Index 805

alpha adrenoceptors on(chicks), 421

Smallwood, R. A., see Mihaly, G.W., 441

Smith, B. R., Van Anda, J., Fouts,J. R. and Bend, J. R.: Esti-mation of the styrene 7,8-ox-ide-detoxifying potential of

epoxide hydrolase in gluts-thione-depleted, perfused ratlivers, 491

Smith, D. E., see Lau, H. S. H.,51

Smith, P. G., see Johnson, M. D.,254

Snow, A. E. and Dewey, W. L.: Acomparison of antinocicep-tion induced by foot shockand morphine, 42

Snyder, S. H., see Katims, J. J.,

167

Solomon, R. E., see Herling, S.,723

Somatostatin, inhibition of car-bachol-stimulated serotonin

release from intestinal enter-

ochromaffin cells (rabbits),

755

Smooth muscle (see Muscle,smooth)

Spealman, R. D.: Maintenance of

behavior by postponement of

scheduled injections of nico-tine in squirrel monkeys, 154

Spinal cord, site of opioid effects

of gastrointestinal transit

(mice), 22

Spinal cord neurons, multiple ac-

tions of phenytoin on (mice),

779

Spinalectomy, effect on footshock-induced antinocicep-

tion (rats), 42

[3HjSpiperone, comparison of

binding properties in stria-turn (rats, rabbits), 592

Stanley, D., see Kalivas, P. W.,229

Stereoselectivity, of discrimina-tive effects of dextrorphan(pigeons), 723

Stimulation

adrenergic, effect on ventricu-lar defibrillation (rats), 716

electrical, effect on release of[3Hjdopamine from caudatenucleus (rabbits), 446

electrical, effect on release ofsubstance P from enteric ner-vous system (guinea pigs),365

Stotz, D. C., see Carroll, M. E., 28Strachan, D. A., see Roach, A. G.,

421Streptomycin, effect on mem-

brane phosphoinositide me-tabolism (rats), 409

Stress

behavioral, beta adrenoceptorantagonism of renal excre-tory response to (dogs), 73

oxidative, plasma glutathione

and glutathione disulfide reg-

ulation and response to

(rats), 749

Striatum, comparison of dopa-

mine receptor sites labeled by

[3H]-S-sulpiride and [3H]spi-

perone in (rats, rabbits), 592Stroo, W. E. and Hook, J. B.:

Dissociation of renal organicanion transport from renallipid metabolism. I. Endoge-nous nonesterified fatty acids

(NEFA), as determinants of

transport, 55

Styrene 7,8-oxide, induced toxic-

ity in liver, ability of epoxide

hydrolase to protect against

(rats), 491Substance P, release from enteric

nervous system (guinea pigs),

365

Sugden, D.: Psychopharmacolog-

ical effects of melatonin inmouse and rat, 587

Sulfobromophthalein, narcotic ef-fects on hepatic disposition(rats), 68

[3H]-5-S-Sulpiride, comparison of

binding properties in stria-

tum (rats, rabbits), 592Surfactants, effect on enteric neu-

rons ofjejunum (rats), 538Sybertz, E. J., Vander Vliet, G.

and Baum, T.: Analysis of the

vasoconstrictor responses to

potassium depolarization and

norepinephrine and their an-tagonism by differing classes

of vasodilators in the per-

fused rat hindquarters, 621

Tachycardia, reflex, effects of dil-

tiazem and hydralazine on

(rats), 472Tang, A. H. and Code, R. A.: Dis-

criminative stimulus proper-

ties of nalorphine in the rhe-

sus monkeys, 563

Tackett, R. L., see Plunkett, L.M., 683

Tanganelli, S., see Moroni, F., 435Tedford, C. E., see Eells, J. T., 349Tephly, T. R., see Eells, J. T., 349Temperature

body, role of dopaminergic andserotonergic mechanisms inaction of apomorphine and

dopamine on (rats), 383

effect on [3Hjspiperone bindingto cortical membranes (rats),

429Terao, N. and Shen, D. D.: Alter-

ations in serum protein bind-

ing and pharmacokinetics ofl-propranolol in the rat elic-

ited by the presence of an

indwelling venous catheter,369

Terao, N. and Shen, D. D.: Effectof experimental renal failure

on the disposition kinetics of

l-propranolol in rats, 295

Teratology, behavioral, of diphen-

ylhydantoin, trimethadione

and phenobarbital (rats), 274Testis, formation of methotrexate

polyglutamate in (rats), 633Tetraethylammonium chloride,

effect on electrical activity

and cable properties of tra-cheal smooth muscle (dogs),706

�9-Tetrahydrocannabinol, respi-ratory and cardiovascular de-pressant effects of (cats), 508

Tetrahydrofolate-dependent me-

tabolism, role of methioninesynthetase in regulation of(monkeys), 349

Theophylline, effect on urinary

prostaglandin excretion(rats), 600

Thermoregulation, central, ef-

fects of dopaminergic andserotonergic antagonists on(rats), 383

Thompson, R. D., see Kusachi, S.,316

Thomsen, R. H. and Wilson,

D. F.: Effects of 4-aminopyr-

idine and 3,4-diaminopyri-dine on transmitter release atthe neuromuscular junction,

260

Threlkeld, P. G., see Fuller, R. W.,354

Thrombosis

coronary artery, effect of dazox-

iben on (dogs), 790

coronary artery, experimental,potentiation of prostacyclin

by aminophylline in (dogs),

288Timolol, effect on antinatriuretic

response to behavioral stress

(dogs), 73

Tokazewski-Chen, S. A., Man-fino, B. J., Jr. and Stebbing,

N.: Effects of nephrectomyon the pharmacokinetics ofvarious cloned human inter-

ferons in the rat, 9

Tolerance

functional, to ethanol, time

course (mice), 150

of morphine, relationship of

dose (chicks), 376Toome, V., see Kolis, S. J., 652Torphy, T. J., Rinard, G. A., Rie-

tow, M. G. and Mayer, S. E.:Functional antagonism in ca-nine tracheal smooth muscle:

Inhibition by methacholine

of the mechanical and bio-

chemical responses to isopro-

terenol, 694Toxicity, of methanol, effects of

nitrous oxide and methionine(monkeys), 349

Transmission

adrenergic, in heart, effects of

angiotensin II (dogs), 676neuromuscular, effects of 4-

aminopynidine and 3,4-dia-minopyridine on (rats), 260

synaptic, in ganglion, effectof 3,4-diaminopynidine on

(frogs), 16

Transport

ofp-aminohippunate in basolat-

eral membrane vesicles(rats), 122

of calcium in liven, inhibition

by nonsteroidal anti-inflam-

matory drugs (hamsters,rats), 84

of renal organic ion, effects of

nonestenified fatty acids on

(rabbits), 55tubular, of p-aminohippunic

acid by kidney (rats), 409

Trapani, A., see Hermsmeyer, K.,322

Tnimethadione, prenatal effects

(rats), 274Tung, C.-S., Goldberg, M. R.,

Hollister, A. S., Oates, J. A.and Robertson, D.: Central

and peripheral cardiovascu-

lar effects of a-methylepine-phnine, 484

Tryptamine-induced convulsions,

inhibition by LY53857 (rats),

327

Tryamine, inhibition of release of

[3H]dopamine from caudate

nucleus by (rabbits), 446

U-50,448H, diuretic effects (rats),35

Uptake

of -y-aminobutynic acid, effect

of nipecotic acid on (rats),

627

of p-aminohippurate from kid-

ney (rats), 122of benzodiazepines into cere-

brospinal fluid (cats), 98

Uranyl nitrate-induced renal fail-ure, effect on pharmacoki-netics of l-propranolol (rats),

295

Van Anda, J., see Smith, B. R.,

491

van der Graaff, M., Vermeulen,N. P. E., Joeres, R. P., Vliets-tra, T. and Breimer, D. D.:Correlation between the invivo metabolism of hexobar-

bital and antipynine in rats,

459

Vander Vliet, G., see Sybertz, E.J., 621

Vanhoutte, P. M., Aarhus, L. L.,Coen, E., Lonenz, R. R., Ri-

mele, T. J. and Verbeuren, T.J.: Effects of buflomedil onthe responsiveness of canine

vascular smooth muscle, 613Vas deferens

alpha-2 blocking action of DG-5128 in (dogs, rats), 194

effect of maitotoxin on tissueCa content in (guinea pigs),

199

Vasodilation

by hydralazine in caudal artery(rats), 322

induced by arachidonic acid, ef-

fect of dazoxiben on (dogs),

790

Veenendaal, J. R., see Meffin, P.J.,732, 739

Veins, small myocardial, role of

beta- 1 adrenergic receptors incontrol of 02 saturation in(dogs), 333

806 Index Vol. 227

Verapamil, relaxant effect on aor-tic rings (rabbits), 767

Venbeuren, T. J., see Vanhoutte,P. M., 613

Verlander, M. S., see Rosenkranz,R. P., 267

Vermeulen, N. P. E., see van den

Graaff, M., 459Vincent, J.-P., see Checler, F., 743

Vinik, A. I., Heldsinger, A. A. andSkoglund, M. L.: Evidencefor histamine H1 and H2 ne-

ceptors in guinea-pig oxynticcells, 115

Vitamin C, inhibition of prosta-

glandin H synthase-activatedbenzidine binding by (nab-bits), 545

Vlietstra, T., see van den Gnaaff,M., 459

Vorhees, C. V.: Fetal anticonvul-sant syndrome in rats: Dose

and period-response relation-

ships of prenatal diphenyl-

hydantoin, tnimethadone andphenobanbital exposure on

the structural and functional

development ofthe offspring,

274

Walle, T., see Bai, S. A., 360Walle, U. K., see Bai, S. A., 360Walker, J. S.,see Au, J. L.-S., 174Warner, M. R., see Moklen, D. J.,

557

Wasserman, M. A., see Weich-man, B. M., 700

Waxman, M. B., see Sharma, A.D., 716

Webster, L. K., see Mihaly, G. W.,

441

Wei, E. T., see Chang, K.-J., 403Wiechman, B. M., Wasserman,

M. A., Holden, D. A., Osborn,R. R., Woodward, D. F., Ku,T. W. and Gleason, J. G.: An-tagonism of the pulmonary

effects of the peptidoleuko-tnienes by a leukotniene D4analog, 700

Weishaan, R. E., Quade, M.,

Schenden, J. A. and Kaplan,

H. R.: The methylenediox-

yindenes, a novel class of “in-tracellular calcium antago-

nists”: Effects on contnactil-

ity and on processes involvedin regulating intracellular

calcium homeostasis, 767

Weiss, H. R.: Role of beta-i ad-

renergic receptors in the con-trol ofthe heterogeneity of 02saturation in small myocar-dial veins, 333

Wenz, M. A. and Macdonald, R.L.: Opioid peptides with dif-fenential affinity for mu anddelta receptors decrease sen-sony neuron calcium-depend-

ent action potentials, 394Widenl#{246}v, E., see Kalivas, P. W.,

229

Williams, T. H., see Kolis, S. J.,652

Wilson, D. F., see Thomsen, R.H., 260

Wilson, M. J., see Bai, S. A., 360

Wise, W. C., see Bunch, R. M., 84

Wise, R. W., see Zensen, T. V.,545

Wong, D. T., see Fuller, R. W.,354

Woods, J. H., see Herling, S., 723Woodward, D. F., see Weichman,

B. M., 700

Worcel, M., see Hermsmeyer, K.,322

Wu, K. M. and Martin, W. R.: Ananalysis of nicotinic andopioid processes in the me-dulls oblongata and nucleusambiguus of the dog, 302

Xylazine-induced contractions in

blood vessels, effect of buflo-medil on (dogs), 613

Yabano, H., see Narita, H., 472Yamaguchi, I., see Narita, H., 472Yamanaka, K., see Muramatsu, I.,

194Yamawaki, S., Lai, H. and Honita,

A.: Dopaminergic and seno-tonergic mechanisms of then-moregulation: Mediation ofthermal effects of apomor-

phine and dopamine, 383Yasumoto, T., see Ohizumi, Y.,

199Yohimbine

antagonism of inhibitory ef-

fects of clonidine and nonepi-

nephnine on release of acetyl-

choline and -y-aminobutynic

acid from brain by (guinea

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effect on digoxin candiotoxicity

(dogs), 683

influence on contractile ne-sponse of aorta to nonepi-

nephnine and clonidine (nab-

bits), 60

Yokotani, K., Muramatsu, I. andFujiwana, M.: Effects of thesympathetic nervous system

on bethanecol-induced ele-

vation of gastric acid secre-

tion and mucosal blood flowin rats, 478

Zaechelein, R., see Goldstein, D.B., 150

Zahnisen, N. R. and Dubocovich,M. L.: Comparison of dopa-mine receptor sites labeled by

[3H]-S-sulpinide and [3H]spi-penone in stniatum, 592

Zehr, J. E., see Opgenorth, T. J.,144

Zensen, T. V., Mattammal, M. B.,

Wise, R. W., Rice, J. R. and

Davis, B. D.: Prostaglandin

H synthase-catalyzed activa-tion of benzidine: A model toassess pharmacologic inter-

vention of the initiation ofchemical carcinogenesis, 545

Zenser, T. V., Palmier, M. 0.,Mattammal, M. B., Bolla, R.

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H synthase-catalyzed bind-ing of two 5-nitrofunan un-

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Zimmerman, D. M., see Leanden,

J.D.,671

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