Immunol Allergy Clin N Am

27 (2007) 141–144

Index

Note: Page numbers of article titles are in bold face type.

A

Albumin, cross-reactivity of, 70

Aldehyde phosphate dehydrogenase,cross-reactivity of, 70

AlgPred database, 5, 14–15

AllAllergy database, 3–4

ALLERDB database, 5–6

Allergen(s)calcium-binding proteins as, 29–44classification of, 1–27Fcc-allergen fusion proteins and,

93–103

food. See Food allergy.immune responses to, 65–78in edible vaccines, 129–139pollen. See Pollen allergens.

Allergen Database for Food Safety, 4, 6

Allergen preparations, 65–78cross-reactive allergens in, 67–73immune responses to, 69–73native allergens in, 66–67recombinant allergens in, 66–67terminology of, 66

Allergome database, 3–5

Allermatch database, 5, 14

Anaphylaxis, blocking of, Fcc-cat allergenfusion proteins in, 95, 97

Animal allergens, classification of, 31

Apple allergy, immunotherapy for, 108–109,112

Ara h allergens, in immunotherapy,115–119

Atopic dermatitis, calcium-bindingproteins in, 32

B

Bioinformatics approach, to allergenclassification. See Databases;

0889-8561/07/$ - see front matter � 2007 Else

doi:10.1016/S0889-8561(07)00014-8

Structural Database of AllergenicProteins.

Biotechnology Information for Food SafetyDatabase, 5

Birch pollen allergenimmune response to, 69immunotherapy for, 108–109

BLAST search tool, 6

C

Calcium-binding proteins, 29–44classification of, 36–39cross-reactivity of, 38–41from food. See Parvalbumins.from pollen. See Polcalcins.human, 32immunoglobulin E-binding activity

of, 36–38overview of, 30–32physiology of, 32–33three-dimensional structure of, 35–38

Casein, cross-reactivity of, 70

Cat allergen fusion proteins. See Fcc-catallergen fusion proteins.

CD1 molecules, in pollen lipid recognition,79–92

importance of, 80–81in presentation, 80mechanisms of, 81–82restricted, 81–86, 88–89

Cdc42, NADPH oxidase interactions with,51–52

Cedar pollen allergy, edible vaccine for,129–139

Central Science Laboratory, allergendatabase of, 4–5

Chimeric Fcc-cat allergen fusion proteins.See Fcc-cat allergen fusion proteins.

Chronic granulomatous disease, NADPHdefects in, 47

vier Inc. All rights reserved.

immunology.theclinics.com

142 INDEX

Classification, of allergens. See Databases;Structural Database of AllergenicProteins.

Cows� milk allergy, immunotherapy for,112–114

Cross-reactivity, of allergenscalcium-binding proteins. See

Calcium-binding proteins.in immunotherapy preparations, 67–73prediction of, 12–20

computational procedure testingin, 13–16

motif-based methods in, 16–17sequence similarity ranking in,

17–19sequence-structural information

combinations in, 19–20

Crp protein, in Japanese cedar pollenimmunotherapy, 134–136

Cry j allergens, of Japanese cedar pollen,131–135

Cyclophilins, cross-reactivity of, 70, 72

Cypress pollen allergens, lipids from,recognition by Cd1-restricted T cells,81–89

Cytochrome b558, as NADPH oxidasesubunit, 52

D

Databases, for allergen classification. Seealso Structural Database of AllergenicProteins.overview of, 3–6

Degranulation, inhibition of, Fcc-catallergen fusion proteins in, 94–96

Dermatitis, atopic, calcium-binding proteinsin, 32

Desensitization, oralfor food allergy, 109–114, 120for Japanese cedar pollen allergy,

129–139

E

Edible vaccine, rice-based, for Japanesecedar pollen allergy, 129–139

EF-hand superfamily. See Calcium-bindingproteins.

Egg allergy, immunotherapy for, 112–114

Escherichia coli, peanut allergens combinedwith, for immunotherapy, 121–122

F

FARRP allergen database, 4

FASTA search, in allergen database, 9,17–18

Fcc-cat allergen fusion proteins, 93–103in anaphylaxis blocking, 95, 97in antibody response modulation, 102in degranulation inhibition, 94–96in rush immunotherapy, 100, 102murine model of, 97–101potential uses of, 102

FccRIIb, in allergic response inhibitions, 94

Fel d1 allergen fusion proteins. See Fcc-catallergen fusion proteins.

Fish allergy. See also Parvalbumins.immunotherapy for, 112–113

Flavin adenine dinucleotide, as NADPHoxidase subunit, 52

Food allergy, 105–127. See alsoParvalbumins.allergen classification in, 31animal models of, 115–116definition of, 105diagnosis of, 105–107epidemiology of, 105, 107immunotherapy for

native food proteins in, 107–109,120

oral desensitization in, 109–114,120

recombinant food proteins in,111, 115–122

non–allergen-specific treatments for,123

Food Allergy Research and ResourceProgram database, 6

Food extracts, immunotherapy with, 111

Fusion proteins, Fcc-cat allergen. See Fcc-cat allergen fusion proteins.

G

Glycolipids, as pollen allergens. See Pollenallergens, lipids from.

G-proteins, NADPH oxidase interactionswith, 51–52

H

Hazelnut allergy, sublingualimmunotherapy for, 111, 120

143INDEX

Hom s 4 allergen, 32

Humoral immune response, to cross-reactive allergens, 69–73

Hypersensitivity, food, animal models of,115–116

I

Immune response, to cross-reactiveallergens, 69–73

Immunoglobulin Ecalcium-binding proteins and, 36–38epitope lists for, 7–8

Immunotherapyallergen-specific, preparations for. See

Allergen preparations.for food allergy

native food proteins in, 107–109,120

oral desensitization in, 109–114,120

recombinant food proteins in,111, 115–122

for Japanese cedar pollen allergy,129–139

fusion proteins in. See Fcc-cat allergenfusion proteins.

Inflammation, reactive oxygen species in, 55

InformAll allergen database, 4

Insulin, cross-reactivity of, 70

International Union of ImmunologicalSocieties, Allergome database of, 3–5

J

Japanese cedar pollen allergy, edible vaccinefor, 129–139

L

Lactoalbumin, cross-reactivity of, 70

Lipids, from pollen allergens. See Pollenallergens, lipids from.

Listeria monocytogenes, peanut allergenscombined with, for immunotherapy,119, 122

M

Manganese-dependent superoxidedismutase, cross-reactivity of, 70–71

Meat, allergens in. See Parvalbumins.

Multiple EM for Motif Elicitation (MEME)motifs, for allergens, 3–5

Muscle, allergens in. See Parvalbumins.

N

NAD(P)H oxidases, 45–63allergic inflammation due to, 55–57cytosolic units of, 48–51G-protein interaction with, 51–52historical perspectives of, 46–47mammalian, 47membrane-associated, 52oxidative stress due to, 55plant, 52–55pollen, 56–57structures of, 53–55

National Center for Food Safety andTechnology, Protall allergen databaseof, 4–5

O

Oral allergy syndrome, immunotherapy for,108–109

Oral desensitizationfor food allergy, 109–114, 120for Japanese cedar pollen allergy,

129–139

Orange allergy, immunotherapy for,112–113

Oxidative burst, in plants, 53

Oxygen, reactive species of. See Reactiveoxygen species.

P

Parvalbuminscharacteristics of, 34–35classification of, 30–32cross-reactivity of, 40physiologic role of, in muscle, 33structures of, 35–36

Peanut allergy, immunotherapy fornative food proteins in, 107–108oral desensitization in, 110, 114recombinant proteins in, 117–122

Pfam grouping, in allergen databases, 7,10–12

Phagocytosis, reactive oxygen species in,46–47

Phospholipase A2, in allergen preparations,66–67, 69

144 INDEX

Phospholipids, as pollen allergens.See Pollen allergens, lipids from.

Polcalcinscharacteristics of, 33–34classification of, 31–32cross-reactivity of, 38–40physiologic role of, in plants, 32–33structures of, 35–38

Pollen allergenscalcium-binding

characteristics of, 33–34classification of, 31–32cross-reactivity of, 38–40physiologic role of, in plants,

32–33structures of, 35–38

examples of, 45–46immunotherapy for, native proteins in,

108–109Japanese cedar, 129–139lipids from

CD1 molecules and, 80–89functions of, 80–82in allergic diseases, 82–86T cells and, 82–89

Pollen–food allergy syndrome,immunotherapy for, 108–109

Profilin, cross-reactivity of, 70–71

Property distance search, in allergendatabase, 8, 17–19

Protall allergen database, 4–5

Protein Data Bank, calcium-bindingallergens in, 35–36

R

Rac proteins, NADPH oxidase interactionswith, 51–52

Ragweed pollen, NAD(P)H oxidase in,56–57

Rboh proteins, in plants, 53–55

Reactive oxygen speciesdiscovery of, 46–47in allergic inflammation, 55in plants, 53

Recombinant allergens, forimmunotherapy, 66–67, 111, 115–122

Respiratory burst, in phagocytosis, 46–47

Respiratory burst oxidase homologue,53–55

Ribosomal protein P2, cross-reactivityof, 70

Rice-based edible vaccine, for Japanesecedar pollen allergy, 129–139

Rush immunotherapy, Fcc-cat allergenfusion proteins in, 100, 102

S

SDAP. See Structural Database ofAllergenic Proteins.

Specific oral tolerance induction, for foodallergy, 109–114, 120

Structural Database of Allergenic Proteinsdatabases integrated with, 7epitope list of, 7–8FASTA search in, 9, 17–18for cross-reactivity prediction, 12–20

computational procedure testingin, 13–16

motif-based methods in, 16–17sequence similarity ranking in,

17–19sequence-structural information

combinations in, 19–20for naming allergens, 9–10overview of, 6Pfam families in, 10–12structure of, 6–7URL of, 4

Sublingual immunotherapy, for foodallergy, 111, 120

Superoxide dismutase, cross-reactivity of,70–71

T

T cell(s)gamma-delta, pollen antigens and,

86–87in pollen lipid recognition

CD1-restricted, 82–86, 88–89gamma-delta type, 86–87

response to cross-reactive allergens,69, 71–72

Thioredoxin, cross-reactivity of, 70–72

V

Vaccine, edible, for Japanese cedar pollenallergy, 129–139

W

WebAllergen database, 5

World Health Organization, allergenicityprediction guidelines of, 5–6