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0031-6997/79/2914-0617$02.00/OPHARMACOLOGICAL REVIEWS
Copyright © 1979 by The American Society for Pharmacology and Experimental Therapeutics
Index
Pharmacological Reviews
Volume 30
1978
Vol. 30, No.4Printed in U.SA
Aaronson, P. See van Breemen et a!., 167Absorption, drug. See Drug absorptionAcetaminophen
-induced hepatotoxicity by phenacetin in the mouse,
inhibition of (table), 466
metabolism, pathways of (fig.), 464
metabolites, and liver necrosis, relationship betweenglutathione levels in liver and cobinding of
(table), 465Acetylcholine
as local hormone, 117cell-cell communication and, 117
determination of, 71
environmental messenger, 116formation of
by coupled synthesis, 74from coenzyme A and choline, 74
growth and, 118
in erythrocytes, 96
in spermatozoa, 99
maturation, development, and, 118
other choline esters and, 68
permeability and, 117placental, effect of drug abuse on intrauterine
growth, 113
roles of, in non-nervous tissues, 116
trophic factors and, 118
Acetyicholine noise, surface of an uninnervated my-
otube (fig.), 421
Acetylcholine power spectra, and synaptic currents,at neonatal and adult rat endplates (fig.),422
Acetylcholine receptor, 71acetylcholinesterase and, accumulation at newly
formed nerve-muscle synapses, 411
brain extract-induced increase in, in cultured my-otubes (fig.), 420
clusters of, 412
on uninnervated myotubes, 413; (fig.), 415distribution of, on an innervated muscle fiber (fig.),
414modification of, 420
synapse formation in vitro, 412Acetylcholine sensitivity, mean channel open time as
function of (fig.), 421Acetylcholinesterase
accumulation of, 423acetylcholine receptors and, accumulation of, at
newly formed nerve-muscle synapses, 411
activities of, in sperm from various segments ofepididymis, 99
curare-treated myotubee stained for (fig.), 425
in erythrocytes, substances that inactivate and theireffects on properties of erythrocyte8 (table),96
in platelets, 96
in sperm fractions, 100
release from platelets, 97Acetylcholinesterase stain and synaptic current decay,
correlation between (fig.), 424Acetyltransferase, choline. See Choline acetyltranafer-
ase
Adaptation and homeostasis, 352Adenine nucleotides, release from platelets, 97
Adenylate cyclase, hormonal modulation of, 405Adipocytes, alpha-adrenoceptors and ion permeability
regulation, 235Adrenergic inhibition and excitation and cardiac mem-
brane currents, 42a-Adrenoceptors and cardiac currents, 44/3-Adrenoceptors and cardiac membrane current sys-
tems, 45Adrenocorticotrophin, estimates of in vivo half-lives
in the rat, dog, sheep, pig, and man (table),260
Age-dependent changesin drug distribution, 447hepatic drug metabolism, 448hepatic microsomal drug-metabolizing system, 452
in hepatobiliary function, 454
noninicrosomal hepatic drug metabolism, 453
renal clearance of drugs, 448Age-related changeS
in drug disposition, 445
intestinal drug absorption, 446Amino acids of glycophorin A (fig.), 375Anaphylaxis with thromboxane A2, prostacyclin, and
prostaglandin endoperoxides, 317
Angiotensins I and II, vasoactive peptides, 253Anodonta cygnea cellensis, components of cholinergic
system in gills of, 79Antiarrhythmic drugs. See under Drugs
Antioxidants, antimutagenic effects of, 549
Antipyrine, genetic factors and variations in elimina-tion rates of (fig.), 559
Arachidonic acidmetabolic pathways of (fig.), 294
metabolism, 295
617
618 INDEX
Arrhythmias, cardiac. See Cardiac arrhythmias
Arrhythmogenesis
altered excitability and, 31
membrane factors in, 24
Ascorbic acid-induced sensitization of human fibroblasts to 4-
nitroquinoline 1-oxide (fig.), 495
mutagemc action and DNA-damaging capacity of
oxidation products of (table), 496
Ataxia telangiectasia, sister chromatid exchange for-
mation in, 526
Bacteria, components of cholinergic systems in, 75
Batzinger, Robert P. See Bueding et al., 547Becker, Bernard. See Newbeme et al., 335
Bennett, Hugh P. J., and Cohn McMartin. Peptide
hormones and their analogues: Distribution,
clearance from the circulation, and inactiva-
tion in vivo, 247
Bioassay of acetylcholine, 71
Bishydroxycoumarin, genetic factors and variations inelimination rates of (fig.), 559
Blohm, Thomas R. Drug-induced lysosomal lipidosis:Biochemical interpretations, 593
Blood cells, cholinergic systems in, 93
Bloom’s syndrome, sister chromatid exchange forma-
tion in, 526
Bolender, Robert P. Morphometric analysis in theassessment of the response of the liver to
drugs, 429
Bousquet, William F. See Newberne et al., 335
Bradykinin, vasoactive peptide, 253Bromobenzene metabolism, pathways of (fig.), 463
5-Bromo-2’-deoxyuridinemethodology for sister chromatid exchange, 501
staining protocols for detecting incorporation of,into metaphase chromosomes (table), 502
techniques, sister chromatid differentiation (fig.),502
Bueding, Ernest, Robert P. Batzinger, Young-NamCha, Paul Talalay, and Christopher J. Moli-neaux. Protection from mutagemc effects of
antischistosomal and other drugs, 547
Calcitonin, 266
arteriovenous differences in radioimmunoassayableconcentrations of, across organs in the dog
(table), 268decay of blood peptide concentrations in vitro and
in vivo, 266estimates of in viva half-lives in preparations in the
rat, dog, pig, and man (table), 267Calcium
role, in receptor regulation of membrane permeabil-ity, 209
sodium-, interactions. See Sodium-calcium interac-tions
Calcium current, agents which modify, 50
Calcium transport and sequestering systems, interre-
lation of, with respect to control of cytoplas-mic ionic calcium (fig.), 201
Calliphora salivary gland, 226Cancer impact of compound, total (table), 353
Carcinogen action
complex patterns of, 496
modulating effect of noncarcinogenic chemicalagents on, 494
CarcinogensDNA and, interactions, 493-DNA interactions, modulating factors, 494hepatic activation of (table), 483risk assessment and acceptable risk, 364
Carcinogenic/mutagenic impact, by chemicals (table),353
Carcinogenesis bioassays, maximum tolerated dose
(MTD), lessons learned from, 362Cardiac arrhythmias
ionic mechanisms in heart muscle in relation togenesis and pharmacological control of, 5
reentry and depressed conduction, 29; (fig.), 30
Cardiac membrane currents
a-adrenoceptors and, 44f1-adrenoceptors and, 45adrenergic inhibition and excitation and, 42; (fig.),
44
Cardiac muscle, acetylcholine action on, 84
Cardiovascular disease, serum dopamine fl-hydroxyl-
888 activity in, 157Cell-cell communication and acetylcholine, 117Cell membrane
hormone receptor interactions at, 393
organization of, development of a model, 394Cell nucleus in toxicological investigations (workshop
summary), 342
Cell surface, implications for toxicology (workshopsummary), 336
Cha, Young-Nam. See Bueding et al., 547Chediak-Higashi syndrome, 589
Chemical agentsnoncarcinogenic
inhibitory action of, on DNA repair, 495
modulating effect of, on carcinogen action, 494Chemical interference with mitochondrial function,
606
Chiorthion effect on metabolism of testosterone byliver microsomes (table), 460
Cholecystokinin, 265Choline acetyltransferases, 70
activities of, in sperm from various segments of
epididymis, 99
biosynthesis of acethycholine, 73
in spermatozoa, 99in sperm fractions, 100
Cholinergic systemcomponents of
in cultured cells and developing cell systems, 90in tissues with nervous and non-nervous compo-
nents, 83
in organisms and tissues without nerves, 75
INDEX
469
in tissues with remote involvement with nervoussystem, 80
in blood cells, 93in developing nerve structures, properties of first
and second phase (table), 92in non-nervous tissues, 65in placenta, 102
in plants, 115in spermatozoa, 98
Cholinesterase, 70assay of, 73
in spermatozoa, 99
Chromatin fiber, 470
folding of, in metaphase chromosomes, evidence forradial loops, 470
organization of, in radial loop model (fig.), 474
Chromosomal assays, mammalian cell models, 542Chromosome
-damaging metabolites, catalytic activity of Cu�
ions on thiol compounds in generating (ta-
ble), 496metaphase
folding of chromatin fiber in, evidence for radialloops, 470
histone-depleted (fig.), 471
surface topology of, electron micrograph (fig.), 473swollen with EDTA, cross section of chromatid of
(fig.), 472
Cilia, acetyicholine role in diary movement, 81
Circadian rhythm, serum dopamine /3-hydroxylase,
150
Clastogens, sister chromatid exchange induction by,
505
Cocaine, relationship between membrane “clamp” po-tential and rise of action potential (fig.), 38
Codeine and morphine, plasma concentrations afteroral aspirin-codeine phosphate combination
(fig.), 462
Copper, catalytic activity of, on thiol compounds ingenerating DNA- and chromosome-damag-ing metabolites (table), 496
Core battery
selection criteria, 544short-term tests (table), 545
Cornea
acetyicholine as sensory mediator, 86
acetyicholine in regulation of water and ion traits-port, 87
Cotten, Marion deV., tribute to, 3Coumarin anticoagulant drugs, pedigree of family in-
dicating incidence of resistance to (fig.), 558C-peptide, 272Cyclophosphamide, sister chromatid exchanges in
mouse liver cells by (fig.), 522
Cysteine
effect on covalent binding of acetaminophen to
mouse liver protein (table), 465effect on mutagemc action and DNA-damaging ca-
pacity of MNNG (table), 495Cytochrome P-450
619
catalytic activity of (table), 461physical properties of (table), 461
Cytoplasm, membrane systems of, implications for
toxicology (workshop summary), 339
DBH. See Dopamine $-hydroxylaseDeoxyribonucleic acid
-carcinogen interactions, modulating factors of, 494damage, assays for, 541
damage, repair, and synthesis, relationship of sisterchromatid exchange to, 524
-damaging metabolites, catalytic activity of Cu��ions on thiol compounds in generating (ta-
ble), 496effectiveness of covalent binding of various standard
substances to (table), 611elution during 5-bromo-2’-deoxyuridine dye-Giemsa
procedure (fig.), 503
fragmentation and repair assays, applications of (ta-ble), 498
fragmentation and repair of mammalian cells, mdi-cater for complex interactions between car-
cinogens and modulating factors, 493
organization levels of, in eucaryotic chromosomes,
repair
inhibitory action of noncarcinogemc chemical
agents on, 495
modulating effect of hyperthermia on, 497; (fig.),497
mechanisms, 493systems responding to alkylation (table), 353
sister chromatid interchange, evidence for, at DNA
level, 528; (fig.), 529synthesis, unscheduled, 543
Diabetes, serum dopamine 16-hydroxylase activity in,159
Diener, Robert M. See Newberne et al., 335Diethyl maleate, effect on covalent binding of acet-
aminophen to mouse liver protein (table), 465Diphenylhydantoin action on cardiac membrane, 40
Dopamine $-hydroxylasebiochemical characteristics, 134
adrenal, 134serum, 135
circadian rhythm effects, 150
enzymatic activity, assay of, 136release of, from an adrenergic varicosity (fig.), 143
serum, 133
activity of, in man and experimental animals (ta-ble), 140
assay procedures for, 136; (fig.), 137, 139
drug and hormone effects on activity of, 150
effects of
growth and development on, 146inheritance on, 147; (fig.), 148
stress on, 151immunoassay of, 141in cardiovascular disease, 157in endocrine disease, 158
Dopamine $-hydroxylase-continued
in familial dysautonomia, 157in human disease, 154in hypertension, 154in manic depression, 158in neuroblastoma, 158in neurological disease, 157in renal disease, 156in schizophrenia, 158in torsion dystonia, 157normal values, 140
regulation of, 145
source and fate of, 143Doxorubicin, ventricular tissue of rat treated with
injections of (fig.) 608Droperidol, cardiac electrophysiological properties of,
38
Drug absorption, intestinal, age-related changes in,
446
Drug abuse, interference with placental acetylcholine,effect on intrauterine growth, 113
Drug and steroid hydroxylation, requirements for (ta-
ble), 460Drug distribution, age-dependent changes in, 447Drug disposition
age-related changes in, 445
in experimental animals, variables affecting (table),560
Drug-induced changes in phospholipid composition oftissues (table), 599
Drug-induced lysosomal lipidosia, biochemical inter-
pretations, 593Drug metabolism. See under Metabolism
Drug-metabolizing enzyme system, hepatic micro-somal, age-dependent changes in, 452
Drug-phospholipid complex formation, 596
Drug response
gene-environment interactions, role of, as determi-
nants of drug response, 560
individual factor in, 555antiarrhythmic
action mechanisms, 33chemical structures (fig.), 35classification of (table), 34
antischistosomal and other, protection from muta-
genie effects of, 547commonly used, pharmacogenetics field expanded
to include, 558coumarin anticoagulant, pedigree of family mdicat-
ing incidence of resistance to (fig.), 558effect on
ciliary movement of Mytilus edulis (table), 78serum dopamine fl-hydroxylase activity, 150
Hodgkin-Huxley theory, application to heart musclein relation to action of, 51
liver response tomodel for assessment of, 430; (fig.), 431, 432, 433morphometric analysis in assessment of, 429
mutagemc activation of, by enteric microorganisms,548
620 INDEX
production of abnormal response in pharmacoge-
netic conditions (table), 556renal clearance of, age-dependent changes, 448toxicology of, workshop on, 335
Electrophysiology, myocardial, 5Endocrine disease, serum dopa.mine f3-hydroxylase ac-
tivity in, 159Endoperoxide analogues, structure of (fig.), 303Endoperoxides, metabolism of, 319
Endorphins, opiate receptor agonists, 251
Enkephalins, opiate receptor agonists, 251
Enteric microorganisms, mutagemc activation of drugs
by, 548Environmental messenger, acetylcholine as, 116
Environment
mutagens and antiniutagens in, 359
mutagens from, source (table), 361Enzymatic catalytic site, distinction from ligand roe-
ognition site, 405
Enzyme, effect of infusion of, on glycogen concentra-
tion and recovery of infused enzyme in liverand muscle in glycogen storage disease Ha
(table), 578Enzyme deficiency diseases, relationship to lysosomal
lipidosis, 593Enzyme system, hepatic microsomal drug-metaboliz-
ing, age-dependent changes in, 452
Enzyme treatment, in five lysosomal disorders, 565Enzymes, inhibition of, in the biosynthetic pathway,
295
Epinephrine, effect of infusion of on glycogen concen-
tration in muscle and liver in glycogen storagedisease II (table), 577
Erythrocytes
acetylcholine in, 96acetylcholinesterase activity in, 93choline acetyltransferase in, 96musearinic receptors in, 96
Estrogen-receptor complexes, 479; (fig.), 480
RNA synthesis and, 485Estrogen-receptor interaction in target cells, 479Eukaryotic chromosomes, DNA organization levels in,
469Eukaryotic microorganisms, point mutation assays,
540
Exocrine glands
calcium and stimulus-permeability coupling mech-
anisms, 214ion movements, role in, 214
mammalian, receptor control ofpermeability in, 225Exocrine pancreas. See under Pancreas
Familial dysautonomia, serum dopamine $-hydroxyl-
ase activity in, 157
Fanconi’s anemia, sister chromatid exchange forma-tion in, 526
Fatty acidsunstable derivatives of, 315
in platelets, 316Fibroblasts, acetylcholine action in, 90Fischbach, Gerald D., Eric Frank, Thomas M. Jessell,
INDEX
Lee L. Rubin, and Stephen M. Schuetze.
Accumulation of acetylcholine receptors and
acetylcholinesterase at newly formed nerve-
muscle synapses, 411
Food, mutagens in (table), 361Food coloring, conversion of, by microflora (fig.), 360
Frank, Eric. See Fischbach et al., 411Frog esophagus, acetylcholine and ciliary movement
in, 81, 82Frog skin, cholinesterases in, 81
Gap junctionshigh resistance, 383
information passed through, 389
in mouse liver (fig.), 384, 385electron micrograph (fig.), 386isolated, high-resistance (fig.), 387
low resistance, 388Gap junction dynamics and intercellular commurnca-
tion, 383
Gas chromatography, acetylcholine, 71Gastrin, 263
estimates of in vivo half-lives in the cat, dog, andman (table), 264
Gastrointestinal epithelia, calcium and stimulus-permeability coupling, 234
Gastrointestinal hormones, 263
Gastrointestinal tract, prostacyclin in, 317Gene conversion, mitotic, assays for mitotic recombi-
nation and, 541
Gene-environment interactions, role, as determinants
of drug response, 560
Gene mutation assays
mammalian cell models, 542
point or, bacterial, 540
Genes directly affecting drug disposition, intraspeciesdifferences in frequency of, 555
Gestation period, placental acetyicholine and trans-
port across placenta as function of, 112, 113
Glucagon, 271
Glucose 6-phosphatase, relative specific activity of,with endoplasmic reticulum (fig.), 434
a-Glucosidase activity in mouse liver after injection of
perfiuorinated particles (fig.), 582
Glutathione levels in liver, relationship with covalent
binding of acetaminophen metabolites andliver necrosis (table), 465
Glutathione depression and hepatic molecular binding,
related to exposure to vinyl chloride (fig.),357
Glycogeneffect of
enzyme infusion on concentration and recoveryof, infused enzyme in liver and muscle of agirl with glycogen storage disease Ha (table),
578
epinephrine infusion on concentration of, in mus-cle and liver in glycogen storage disease II
(table), 577Glycogen degradation, cytoplasmic phosphorylase
pathway of, activated by epinephrine infusion
621
(fig.), 568
Glycogenesis type H, prototype of lysosomal disease,566
Glycogen storage disease
classification of (table), 567II
treatment, 575
haamniotic fluid cell of an 18-week-old fetus with
(fig.), 583
effect of enzyme infusion on glycogen concentra-
tion and recovery of infused enzyme in liver
and muscle of a girl with (table), 578liver biopsy specimen (fig.), 576
after enzyme infusion (fig.), 579
after epinephrine infusion (fig.), 577
after 3 weeks of enzyme infusion (fig.), 578before infusion of enzymes (fig.), 568, 569
liver specimen of 18-week-old fetus (fig.), 571
muscle biopsy specimen (fig.), 570
skin fibroblasts of, that have ingested gold parti-
des (fig.), 580
hlbheart autopsy specimen (fig.), 573, 574
muscle biopsy specimen (fig.), 572muscle biopsy specimen in 11-year-old boy with
no clinical signs of the disease (fig.), 575
Glycophorin A
amino acids of (fig.), 375
lipid layer of intact red cell membrane, 376
multimeric forms, 377
phosphorylated molecules of, 378
Glycophorins, 374
Glycoprotein hormones, 278
anterior pituitary, 276
Golberg, Leon. Toxicology: Has a new era dawned?351
Goodenough, Daniel A. Gap junction dynamics and
intercellular communication, 383
Granuloma pouch assay, 613
Gray, Jack E. See Newberne et al., 335Growth
acetylcholine and, 118
development and, effects on serum dopamine ,8-hy-droxylase, 146
intrauterine, retardation of, relationship to placental
acetylcholine and drugs of abuse, 113Growth control, receptor regulation and, 400
Growth hormone, 276
release inhibiting hormone or somatostatin, 258
Haemostasis, prostacyclin, and thromboxane A1-thrombosis, 313
Halothane metabolism, oxidative and reductive path-ways of, schematic representation (fig.), 358
Hauswirth, Otto, and Bramah N. Singh. Ionic mech-anisms in heart muscle in relation to thegenesis and the pharmacological control ofcardiac arrhythmias, 5
Heart. See aLso entries under Cardiac, Myocardial
Heart muscle
622 INDEX
Immunochemical approaches to receptor studies, 487Inflammation, thromboxane A2, prostacyclin, and
Heart muscle-continued
Hodgkin-Huxley theory application to, in relationto drug action, 51
ionic mechanisms in, in relation to genesis and phar-macological control of cardiac arrhythmiaa,
5
Hemopoietic stem cell, component of cholinergic sys-tem in, 92
Hepatic activation of carcinogens (table), 463
Hepatic drug metabolism. See under Metabolism
Hepatic microsomal drug-metabolizing enzyme sys-tem, age-dependent changes in, 452
Hepatic molecular binding and glutathione depression,
related to exposure to vinyl chloride (fig.),
357Hepatobiliary function, age-dependent changes in, 454Hepatocytes
hypothetical, containing a single spherical nucleus,changes occurring within (fig.), 435
stereological sorting of subpopulations of (fig.), 441
Hepatotoxicity, acetaminophen-induced, inhibition by
phenacetin in the mouse (table), 466Hexachiorophen and two stereoisomers, chemical
structures showing neurotoxicity (fig.), 607Hodgkin-Huxley concept, mechanisms of excitation,
10; (fig.), 11, 12, 14, 15, 17Hodgkin-Huxley model. modification of, 17; (fig.), 18,
19Hodgkin-Huxley theory, application to heart muscle
in relation to drug action, 51Hollenberg, Morley D. Hormone receptor interactions
at the cell membrane, 393
Homeostasisadaptation and, 352; (fig.), 354
vascular, prostacyclin release and role in, 310
Hormone
adenylate cyclase modulation by, 405
bound, intracellular localization of, 479effects on serum dopamine �8-hydroxy1ase activity,
150
hypothalamic, 256
local, acetylcholine as, 117
neurohypophyseal
analogues of, 255oxytocin and vasopressin, 254
pancreas, 271
parathyroid, 269
circulating forms of, 270
half-life in blood in vitro and in vivo, 269role of tissues in clearance and conversion of, 270
peptide
analogues and, distribution, clearance from cu-culation, and inactivation in viva, 247
anterior pituitary, 259assay, characterization and identification of, 249bioassay of, 249
biological experimental methods, 250chromatography, 249
comparison of metabolism of, 279concentrations in blood, role of tissues in decay
of, 264
identification of, 249
isotopically labelled, 249levels
blood, decay of, in vitro and in vivo, 255role of tissues in decay of, 255
low molecular weight, primary structures of (fig.),252
mechanisms of clearance and distribution, 280
metabolism. See under Metabolismpyrolysis products isolated from (fig.), 361radioimmunoassay of, 249vasoactive, 253
protein, of anterior pituitary, 276
receptor modulation by, 400
receptor regulation and tachyphylaxis, 401steroid, interaction of, with the nucleus, 477
Hormone acceptors versus receptors, 398
Hormone action
ligand internalization and, 402
membrane fluidity and mobile receptor paradigm of,395
mobile receptor model of (fig.), 394
predictions based on mathematical analysis of,
395receptor aggregation and, 396
receptor cooperativity and, 404Hormone binding in target tissues, 478; (fig.), 478Hormone receptors
acceptors and, the problem of nonspecific binding,397
interactions at cell membrane, 393
regulation, 398
versus acceptors, 398
Hot spots, nerve-induced, 418; (fig.), 416Hottendorf, F. H. See Newberne et al., 335Hug, George. Pre- and postnatal pathology, enzyme
treatment, and unresolved issues in five ly-sosomal disorders, 565
Human chromosome fragility diseases, sister chroma-tid exchange formation in, 526
Human respiratory epithelium, acetylcholine and cull-sty activity in, 82
Hurler’s disease, 583
cerebral cortex specimen of 19-week-old fetus with(fig.), 588
liver specimen of 19-week-old fetus with (fig.), 587
skin fibroblasts of, that pinocytosed colloidal gold
(fig.), 586
Hycanthone, radioactivity in sperm ejaculated after
injection of (table), 6135-Hydroxytryptamine, release from platelets, 97
Hypertension, serum dopamine fl-hydroxylase activityin, 154
Hyperthermia, modulating effect of, on DNA repair,497; (fig.), 497
Hypothalamic hormones, 256
INDEX 623
prostaglandin endoperoxides in, 317Inheritance, effects of, on serum dopamine $-hydrox-
ylase, 147Insulin, 272
estimates of in vivo half-lives of, in pig, baboon, andman (table), 273
Intercellular communication and gap junction dynam-
ics, 383
Intestine
acetylcholine in, 83
drug absorption in, age-related changes, 446
Intracellular interaction mechanism, 482Ionic mechanisms, in heart muscle in relation to gen-
esis and pharmacological control of cardiacarrhythmias, 5
Jensen, Elwood V. Interaction of steroid hormoneswith the nucleus, 477
Jessell, Thomas M. See Fischbach et al., 411
Lacrimal glands, ion permeability control, 221Latt, Samuel A., Rhona R. Schreck, Kenneth S. Love-
day, and Charles F. Shuler. In vitro and invivo analysis of sister chromatid exchange,
501
Leucocytes, cholinergic system components in, 98Lidocaine action on cardiac membrane, 40
Ligand internalization and hormone action, 402Ligand recognition site, distinction from enzymatic
catalytic site, 405
Lipid matrix, amphipathic, 371
Liver. See also Hepatic
adaptive changes that permit maintenance of lowconcentration of the toxic agent in (rat) (fig.),
355
autopsy specimen after injection with perfluorinatedparticles and colloidal gold (fig.), 581
correlation between content of polychlorinated bi-phenyl and the mitochondrial #{246}-aminolevu-
linic acid synthetase activity (fig.), 356membrane permeability modulation by calcium and
cyclic AMP, 228morphological and biochemical data, relationship,
431response to drugs
model for assessment of, 430; (fig.), 431, 432, 433morphometric analysis in assessment of, 429
Liver cellmouse
sister chromatid exchange in (fig.), 521
sister chromatid exchange induction in, by cyclo-phosphamide (fig.), 522
Liver microsomal drug metabolism (table), 458Liver necrosis, glutathione levels in liver, covalent
binding and, relationships with (table), 465
Liver protein, effect of diethyl maleate or cysteine oncovalent binding of acetaminophen to
(mouse) (table), 465
Loutzenhiser, R. See van Breemen et al., 167
Loveday, Kenneth S. See Latt et al., 501
Luteinizing hormone/follicle-stimulating hormone-re-
leasing hormone or luliberin, 257
e8tlmates of in vivo half-lives in rat, dog, pig, andman (table), 257
Luteinizing hormone-releasing hormone
blood concentrations
decay of, in vitro and in viva, 257role of tissues in decay of, 258
Lymphocytes, cholinergic system components in, 97Lysinoalanine toxicity (fig.), 360
Lysosomal disease
glycogenesis type II, the prototype of, 566in toxicology (workshop summary), 347
Lysosomal disorders, pro- and postnatal pathology,enzyme treatment, and unresolved issues in,565
Lysosomal enzyme activities in “normal” cultured fi-broblasts (table), 579
Lysosomal lipidosis
drug-induced, biochemical interpretations, 593
relationship to enzyme deficiency diseases, 593Lysosomes
function and dysfunction of, 565function of, as intracellular disposal system (fig.),
566
in toxicology (workshop summary), 347membrane stabilization with, 597
Lysosomotropism, 598
Mammalian cells
DNA fragmentation and DNA repair of, indicatorfor complex interactions between carcinogens
and modulating factors, 493microbial and, application to assessment of muta-
genicity, 537models, 542
Manic depression, serum dopamine /3-hydroxylase ac-
tivity in, 158
Marchesi, Vincent T. Functional components of sur-face membranes: Potential targets for phar-
macological manipulation, 371
Maturation and development, acetylcholine and, 118Meiotic cells, sister chromatid differentiation in, 522
a-Melanocyte-stimulating hormone, (melanostatin)
256, 259
Membrane. See also Cardiac, Cell, and Surface mem-brane
Membrane permeability, role of calcium in receptor
regulation of, 209Membrane response to uniform current, 9Membrane systems of cytoplasm, implications for tox-
icology (workshop summary), 339
Metabolic activation procedures, 541Metabolic conjugation, time-scale in discovery of (ta-
ble), 352Metabolism
acetaminophen, pathways of (fig.), 464
arachidonic acid, 295; (fig.), 294bromobenzene, pathways of (fig.), 463
drug
624 INDEX
Metabolism-continued
in liver, age-dependent changes in, 448liver microsomal (table), 458
toxicological implications, 457nonmicrosomal hepatic, age-dependent changes
in, 453
endoperoxides, 319
halothane, oxidative and reductive pathways of,
schematic representation (fig.), 358
peptide hormone
arteriovenous differences in vivo, 250blood and plasma in vitro, 250blood or plasma kinetics in viva, 250clearance processes involved in (table), 283comparison of, 279distribution studies in vivo, 250
isolated perfused organs and tissues, 250
processes involved in, 248prostacydlin, 320
testosterone, by rat liver microsomes, chiorthioneffect on (table), 460
thromboxane A2, 320Metabolites, DNA- and chromosome-damaging cata-
lytic activity ofCu� ions on thiol compounds
in generating (table), 496Metachromatic leucodystrophy (MW), 588
3-Methylcholanthrene, effect on liver microsomal cy-
tochrome P-450 and benzo(a)pyrene hydrox-ylase activity (rat) (fig.), 459
Methylguanidine, nitrosation prevention by sodium
ascorbate (fig.), 494
Microbial cellassays, 537
mammalian and, application to assessment of mu-
tagenicity, 537
Mitochondria, effects ofthickening agents on oxidative
phosphorylation in (rat) (table), 609
Mitochondrial function, chemical interference with,606
Mitomycin C, sister chromatid exchanges in humanperipheral lymphocyte by (fig.), 506
Moncada, S., and J. R. Vane. Pharmacology and en-dogenous roles of prostaglandin endoperox-
ides, thromboxane A2, and prostacyclin, 293Morphine and codeine, plasma concentrations after
oral aspirin-codeine phosphate combination(fig.), 462
Morphometry and the future, 441Mucocutaneous membranes, cholinesterases in, 81Mucopolysaccharidosis type I (MPS I), Hurler’s die-
ease, 583
Mucosulfatidosis
cerebral cortex biopsy specimen in (fig.), 585liver biopsy specimen of (fig.), 584multiple sulfatase deficiency, 588
Multiple sulfatase deficiency. See MucosulfatidosisMuscle. See Cardiac, Heart, Skeletal, and Smooth
muscle.
Musculotendinous junctions, acetylcholinesteraseconcentration at, 80
Mutagenesis, implications for toxicology (workshop
summary), 344
Mutagemc activity, reduction of, by pretreatment with2,(3)tert-butyl-4-hydroxyanisole or coadmin-
istration of erythromycin (table), 550Mutagemc effects, protection from, of antischistoso-
mal and other drugs, 547Mutagenicity
application of microbial and mammalian cells toassessment of, 537
testing procedures (table), 538testing requirements (table), 544
Mutagensantimutagens and, environmental, 359
environmental, sources (table), 361infood(table),361
Mutations, preadaptive, affecting the disposition of
and response to foreign compounds, 555Myocardial electrophysiology, 5
Mytilus edulis
components of cholinergic systems in gill plates of,77
drug effects on ciliary movement of (table), 78
Neoplastic disease, serum dopamine fl-hydroxylase ac-
tivity in, 158Nerve-muscle synapses
acetylcholine receptors and acetylcholinesterase ac-
cumulation at, 411
functionally identified, electron micrograph (fig.),419
Nerve structures, developing, properties of first and
second phases of cholinergic system in (ta-ble), 92
Nerves
hot spot induction, 418; (fig.), 416motor, induction of new receptor clusters, 416organisms and tissues without, components of cho-
linergic systems in, 75Nervous tissues, non-
acetylcholine roles in, 116
cholinergic systems in, 65Neuroblastoma
cholinergic system component in, 92serum dopamine ,8-hydroxylase activity in, 158
Neuroblasts, development of cholinergic system in, 91Neurohypophysial hormone. See under HormoneNeurological disease, serum dopamine /1-hydroxylase
activity in, 157Neuromuscular junctions, adult, acetylcholine recep-
tors and acetylcholinesterase at, 411Neurotoxic activation (fig.), 359
Neurotoxicity of hexachiorophene and two stereoiso-
mers, chemical structures of (fig.), 607
Neutrophils, leukocyte function and receptor activa-tion, dependence upon calcium, 236
Newberne James W., Bernard Becker, William F.
Bousquet, Robert M. Diener, Jack E. Gray,
G. H. Hottendorf, Emil A. Pfitzer, Gregory S.Probst, Virgil B. Robinson, Richard L Steel-
INDEX
man, and Robert J. van Ryzin. Summary of
the workshop on cellular and molecular tox-icology, 335
Non-nervous tissues. See Nervous tissues, non-Nuclear interaction, nature of, 483
Nucleosome, 469
Nucleus, steroid hormone interaction with, 477
Opiate receptor agonists, enkephalins and endorphins,251
Oxidative phosphorylation, effects of thickening
agents on, in rat mitochondria (table), 609
Oxytocin, 254
Pacemaker potential, mechanism of, 20; (fig.), 21
Pancreas
exocrine cells of, changes in surface area (fig.), 437
exocrine, role for calcium in modulating ion perme-
abilities in, 223
hormones of, 271
Parathyroid hormone. See under Hormone
Peptide, C-, 272
Peptide hormone. See under HormonePeptide hormone metabolism. See under MetabolismPermeability and acetylcholine, 117Permeability coupling, stimulus-. See Stimulus-perme-
ability coupling
Permeability, membrane. See Membrane permeabilityPfitzer, Emil A. See Newberne et al., 335Pharmacogenetics
expansion of field to include commonly used drugs
and more subjects, 558pedigree of family indicating incidence of resistance
to coumarin anticoagulant drugs (fig.), 558with putative aberrant enzyme, mode of inheritance,
frequency, and drugs that can elicit the signsand symptoms of the disorder (table), 556
Phenacetin, inhibition ofacetaminophen-induced hep-
atotoxicity by (mouse) (table), 466Phenobarbital
effect on
liver microsomal cytochrome P.450, ethylmor-phine N-demethylase activity, and antipyrine
(rat) (fig.), 459
surface area of the endoplasmic reticulum andoxidative demethylase (fig.), 439, 440
Phospholipid composition of tissues, drug-inducedchanges in (table), 599
Phospholipid-drug complex formation, 596
Physical and chemical agents, homeostatic mecha-nisms of a multicellular organism and its
adaptive responses to (fig.), 354
Pituitary, anterior, protein and glycoprotein hormonesof, 276
Placenta
cholinergic system in, 80
cow, acetyicholine-like activity in, 114human
acetylcholine, 103
and transport of chemicals across placenta as
625
function of gestation, 112, 113
effects on blood vessels, 109receptor in, 109
synthesis in, precursors for, 108uptake by fragments of, 108
biogenic amines and other endogenous sub-stances, effect on perfusion pressure of (ta-ble), 110
choline acetyltransferases in, 103
cholinesterases in, 103drug interference with placental acetylcholine, ef-
fect on intrauterine fetal growth, 113monkey, choline acetyltransferase activity, 113mouse, choline acetyltransferase activity, 115
rabbit, acetylcholine-like substances in, 114rat, choline acetyltransferase activity, 115
species variation in cholinergic systems of, 115Placental lactogen, 277
Plants, cholinergic system in, 115
Plasma metabolism, tissue homogenates or slices, 250Platelet aggregation, prostaglandin endoperoxides and
thromboxane A2 in, 302
Plateletsacetylcholine and acetylcholine receptor in, 97acetylcholinesterase in, 96choline acetyltransferase activity in, 975-hydroxytryptamine, adenine nucleotides and ace-
tylcholinesterase release from, 97unstable derivatives of fatty acids in, 316
Point mutation assayseukaryotic microorganisms, 540
gene or, bacterial, 540mammalian cell models, 542
Polychiorinated biphenyl, liver content of, correlationwith 6-aminolevulinic acid synthetase activ-ity (fig.), 356
Postnatal pathology in five lysosomal disorders, 565Potassium currents, compounds influencing, 47; (fig.),
48
Prenatal pathology in five lysosomal disorders, 565Procainamide, antiarrhythmic and arrhythmogenic
properties of, 39, 40Probst, Gregory S. See Newberne et al., 335Proinsulin, 272
estimates of half-lives of, in the pig, baboon, andman (table), 273
Prolactin, 277
Prostacyclin, 306
metabolism of, 320
prostaglandin endoperoxides, thromboxane A2 and,pharmacology and endogenous roles of, 293
therapeutic potential of, 315thromboxane A2-thrombosis, hemostasis and, 313release and role in vascular homeostasis, 310thromboxane A2, imbalance in other pathological
states, 320synthetase, 296
tissues described in (table), 298Prostaglandin endoperoxides
rabbit aorta contracting substance and, 296
626 INDEX
Prostaglandin endoperoxides-continued
thromboxane A2 and, in platelet aggregation, 302
prostacyclin and, pharmacology and endogenous
roles of, 293Protein hormones of the anterior pituitary, 276Protein
mouse liver, effect of diethyl maleate or cysteine oncovalent binding ofacetaminophen to (table),465
“functional,” isolation and characterization of, 379membrane, properties of, 373
pyrolysis products isolated from (fig.), 361
Protozoa, components of cholinergic systems in, 76Psychiatric disease, serum dopamine /3-hydroxylase
activity in, 158Purkinje fiber, action potential (fig.), 23
Putney, James W., Jr. Stimulus-permeability coupling:
Role of calcium in the receptor regulation ofmembrane permeability, 209
Pyridine nucleotide, reduced form of, electron traits-
port to drug substrate (fig.), 458
Pyrolysis products from proteins, peptides and their
amino acids (fig.), 361
Quinidine, cardiac electrophysiological effects of, 39
Ray, Verne A. Application of microbial and mamma-
lian cells to the assessment of mutagemcity,
537Receptor. See also Acetylcholine, Hormone, Estrogen,
and Salivary glandactivation, 481
adenylate cyclase coupling, 406
studies, immunochemical approaches to, 487translocation, 480
mechanism, evidence for (table), 481Red blood cell
calcium and regulation of membrane permeabilityto K, 211
components of cholinergic system in, 79membrane, lipid bilayer, glycophorin A and, 376
Renal clearance of drugs, age-dependent changes in,448
Renal disease, serum dopamine fl-hydroxylase activity
in, 156Repolarization, underlying mechanisms, 22; (fig.), 23Reproductive system, prostacyclin in, 317Ribonucleic acid synthesis, estrogen-receptor corn-
plexes and, 485Robinson, Virgil B. See Newberne et al., 335Rubin, Lee L. See Fischbach et al., 411
Sadavongvivad, C. See Sastry and Sadavongvivad, 65Salarnanders, acetylcholine and limb regeneration in,
88
Salivary glandscalcium channel, nature of, 218calliphora, ion transport and water movement, con-
trol by membrane receptors, 226other ionic fluxes, 220
receptors; Ca and K flux, 214; (fig.), 216
stimulus-permeability coupling mechanisms, modelfor study, 214
San, R. H. C. See Stich et al., 493
Sarcolemma, cholinesterases in, 80, 81Sarcoplasm, cholinesterases in, 80,81Sastry, B. V. Rama, and C. Sadavongvivad. Choliner-
gic systems in non-nervous tissues, 65Schizophrenia, serum dopamine f3-hydroxylase activ-
ity in, 158
Schmucker, Douglas L. Age-related changes in drugdisposition, 445
Schreck, Rhona R. See Latt et al., 501Secretin, 265Shuetze, Stephen M. See Fischbach et al., 411Shuler, Charles F. See Latt et al., 501Singh, Bramah N. See Hauswirth and Singh, 5Sister chromatid differentiation
5-bromo-2’-deoxyuridine-dye techniques (fig.), 502
induction of, in Chinese hamster ovary chromo-
somes (fig.), 504
in meiotic cells, 522Sister chromatid exchange
agents capable of inducing, strongly positive (table),507
agents exhibiting mixed or weak induction behavior
(table), 516agents found not to induce (table), 519
analysis of, 501basic information, 505biological significance of formation of, 525
5-bromo-2’-deoxyuridine dye methodology for, 501extension of studies of, from in vitro to in vivo
systems, 505
formation of, in human chromosome fragility dis-eases, 526
human lymphocytes (fig.), 504
induction ofby clastogens, 505in human peripheral lymphocyte by mitomycin C
(fig.), 506
in mouse liver cells by cyclophosphamide (fig.),522
induction tests, interpretation of, 523in mouse liver cell (fig.), 521
mechanism of formation of, 528
relationship ofinduction of, to DNA damage, repair,and synthesis, 524
Sister chromatid interchange, evidence for, at the
DNA level, 528; (fig.), 529
Skeletal muscle, components of cholinergic systems in,80
Smooth muscleacetylcholine action in, 83
alimentary tractouabain and zero potassium, inhibition of sodium,
potassium adenosine triphosphatase, 188potassium elevation, effects of, 183
sodium substitution experiments, 175mammalian, sodium-calcium interactions in, 167
mechanisms and coupling factors in membranepermeability, 231
INDEX 627
ureter
Na,K pump blockade, effects of, 199
sodium substitution, effects, 197
uterine
Na,K ATPase inhibition, effects of, 196sodium substitution, 194
vascular
effects of sodium substitution, 170
sodium, potassium, and adenosine triphosphataseinhibition, 173
Sodium-calcium interactions
in mammalian smooth muscle, 167molecular mechanisms, 167; (fig.), 168specific cellular sites for, 170
Sodium current, fast, compounds influencing, 37Sodium gradient and muscle tension, theoretical rela-
tionship between (fig.), 202Somatostatin, 258
Somatotrophin, 276
Sperm
from various segments of epididymis, choline ace-tyltransferase and acetylcholinesterase activ-ities in, 99
human, effect of cholinergic and cholinergic block-ing drugs on motility of, 101
sea urchin, effects of cholinergic and cholinergicblocking agents on motility of sperm from,
100; (table), 101Spermatozoa
cholinergic system in, 79,80,98
sterility and, 102Sperm fractions, choline acetyltransferase and acetyl-
cholinesterase in, 100
Sperm motility, effects of cholinergic and cholinergicblocking agents on, 100
Spider, acetylcholine in silk glands of, 87Spleen, acetylcholine and propionylcholine in, 84
Steelman, Richard L. See Newberne et a!., 335Sterility, spermatozoal cholinergic system and, 102Steroid and drug hydroxylation, requirements for (ta-
ble), 460Stich, H. F., R F. Whiting, L Wei, and R H. C. San.
DNA fragmentation and DNA repair of
mammalian cells as an indicator for the corn-plex interactions between carcinogens and
modulating factors, 493Stimulus-permeability coupling, role of calcium in re-
ceptor regulation of membrane permeability,
209
Stress, effects on serum dopamine /3-hydroxylase ac-
tivity, 151Surface membranes, functional components of, targets
for pharmacological manipulation, 371
Symposium, workshop on cellular and molecular tox-icology, 335
Synaptic current
acetylcholine power spectra and, at neonatal andadult rat endplates (fig.), 422
decay, variation in rate of (fig.), 424
Tachyphylaxis and receptor regulation, 401
Target cells, estrogen-receptor interaction in, 479
Target tissues, hormone binding in, 478; (fig.), 478
Testosterone, chlorthion effect on metabolism of, byrat liver microsomes (table), 460
Tetrodotoxin, influence on fast sodium current, 37Thickening agents, effects of, on oxidative phoapho-
rylation in rat mitochondria (table), 609Thiol compounds, catalytic activity of Cu� ions on,
in generating DNA- and chromosome-dam-aging metabolites (table), 496
Thromboxane synthetase, 296Thromboxane A2, 301
metabolism of, 320prostacydlin and, imbalance in other pathological
states, 320prostaglandin endoperoxides and, in platelet aggre-
gation, 302
prostaglandin endoperoxides, prostacydlin and,
pharmacology and endogenous roles of, 293-thrombosis, prostacydlin, and hemostasis, 313
synthetase, tissues described in (table), 2973H-Thymidine, radioactivity in rabbit sperm after in-
jection of (fig.), 613
Thyroid and parathyroid, calcium regulating hor-
mones of, 266
Thyroid disease, serum doparnine$-hydroxylase activ-ity in, 159
Thyroliberin, 256
Thyrotropin-releasing hormone or thyroliberin, 256
Tissues
nonexcitable, calcium and receptor-mediated con-trol of ion permeability, 233
non-nervous, cholinergic systems in, 65
remote involvement with nervous system, compo-nents of cholinergic systems in, 80
Torsion dystonia, serum dopamine �8-hydrozylase ac-tivity in, 157
Toxic agents
in rat liver, adaptive changes that permit mainte-
nance of low concentration of (fig.), 355time scale in discovery of metabolic conjugation
(table), 352Toxicant, interrelationships between sequence of bio-
chemical changes caused by, and associatedpathological events (fig.), 357
Toxicity effect on homeostasis, 352Toxicological investigations, cell nucleus and related
factors�in (workshop summary), 342Toxicological testing, scientific approaches to, 606
Toxicologyapplication of basic concepts to research in, 605
summary of workshop on, 347basic science in, request for more, 605cellular and molecular
summary of workshop on, 335
workshop on, 335
implications for
membrane systems of cytoplasm (workshop sum-
mary), 339
mutagenesis (workshop summary), 344on the cell surface (workshop summary), 336
�‘�±(“�1 Library
.- � . : � � :OSPITAL
628 INDEX
Toxicology-continued
lysosornal diseases in (workshop summary), 347
lysosomes in (workshop summary), 347
new era, 351
summary of workshop on, 335
pharrnacokinetic and metabolic considerations, 611pharmacological approach to, 610
Trachea, acetylcholine and cilia movement in (rabbit),82
Trophic factors and acetylcholine, 118
van Breemen, C., P. Aaronson, and R. Loutzenhieer.
Sodium-calcium interactions in mammaliansmooth muscle, 167
Vane, J. R. See Moncada and Vane, 293van Ryzin, Robert J. See Newberne et aL, 335
Vasopressin, 254
Vesell, Elliot S. Intraspecies differences in frequency
of genes directly affecting drug disposition:
The individual factor in drug response, 555Vinyl chloride, hepatic macromolecular binding and
glutathione depression related to exposure to
(fig.), 357Voltage clamp versus standard electrophysiological
techniques, 37; (fig.), 37,38Wei, L. See Stich et al., 493Weinshilboum, Richard M. Serum dopamine �-hy-
droxylase, 133
Welch, Richard M. Toxicological implications of drug
metabolism, 457Whiting, R. F. See Stich et al., 493Workshop on cellular and molecular toxicology, 335
Zbinden, Gerhard. Application of basic concepts toresearch in toxicology, 605
Zonula occludens in mouse liver (fig.), 384, 385
629
0031-6997/79/3004-0629$02.O0/OPHARMACOLOGICAL REVIEWSCopyright © 1979 by The American Society for Pharmacology and Experimental Therapeutics
Author Index
Pharmacological Reviews
Volumes 1-30
1949-1978
Vol. 30, No.4Printed in USA.
Abraham, E. P. The cephalosporins, 14, 473Adler, T. K. See Way and Adler, 12, 383
Aggeler, Paul M. See O’Reilly and Aggeler, 22, 35Ahiquist, R. P. The receptors for epinephrine and
norepinephrine, a discussion, 11, 441
Akera, Tai, and Brody, Theodore M. The role of
Na�,K�-ATPase in the inotropic action of digitalis,29, 187
Albert, Adrien, Ionization, pH, and biological activity,4, 136
Allen, David G. See Blinks et al., 28, 1Allen, Julius C. See Schwartz et al., 27, 3Ambache, N. Choline esters as local hormones, 6, 113
, The use and limitations of atropine for phar-
macological studies on autonomic effectors, 7, 467Anderson, Hamilton R., and Hansen, Eder L. The
chemotherapy of amebiasis, 2, 399
Andersson, Bengt, and Larsson, Stig. Physiological
and pharmacological aspects of the control of hun-ger and thirst, 13, 1
Angeletti, Piero U. See Levi-Mont.alcini and Angeletti,18, 619
Archer, J. A. See Gorden et al., 25, 179Ari#{235}ns, E. J., van Rossum, J. M., and Simonis, A. M.
Affinity, intrinsic activity, and drug interactions, 9,218
Armentrout, Steven A. See Beard et al., 21, 213Armstrong, Marvin D., and McMillan, Armand. Stud-
ies on the formation of 3-methoxy-4-hydroxy-D-
mandelic acid, a urinary metabolite of norepineph-
line and epinephrine, 11, 394Ashmore, James. See Mayhew et al., 21, 183Atack, C. V. See Carlsson et al., 24, 371Aviado, Domingo M. The pharmacology of the pul-
monary circulation, 12, 159Axelrod, Julius. The metabolism of catecholamines in
viva and in vitro, 11, 402-, Methylation reactions in the formation and me-
tabolism of catecholamines and other biogenic
amines, 18, 95
, Dopamine-$-hydroxylase: regulation of its syn-thesis and release from nerve terminals, 24, 233
, See Glowinski and Axelrod, 18, 775, See Lemberger et al., 23, 371
Bacq, Z. M. Metabolism of adrenaline, 1, 1-, Summary ofdiscussion and commentary, 18, 313Baer, John E. See Beyer and Baer, 13, 417Baird, Joyce D. See Duncan and Baird, 12,91
Baker, J. B. E. The effects of drugs on the foetus, 12,37
Baliga, B. S. See Wurtman et aL, 24, 411Banks, P., and Blaschko, H. Chromaffin tissue, 18, 453Barnes, J. M., and Denz, F. A. Experimental methods
used in determining chronic toxicity, 6, 191
-, and Stoner, H. B. The toxicology of tin com-
pounds, 11, 211
Batzinger, Robert P. See Bueding et al, 30, 547Beard, N. Shelley, Jr., Armentrout, Steven A., and
Weisberger, Austin S. Inhibition ofmaminalian pro-tein synthesis by antibiotics, 21, 213
Becker, Bernard. See Newberne et al., 30, 335Beecher, Henry K. The measurement of pain, 9, 59Beets, M. G. J. The molecular parameters of olfactory
response, 22, 1Bein, H. J. The pharmacology of Rauwolfia, 8, 435Bell, Christopher. Autonomic nervous control of re-
production: circulatory and other factors. 24, 657Belleau, B. Steric effects in catecholamine interactions
with enzymes and receptors, 18, 131Bennett, Ivan L., Jr., and Cluff, Leighton E. Bacterial
pyrogens, 9, 427Berger, F. M. Spinal cord depressant drugs, 1, 243Bergstrom, Suite, Carbon, Lars A., and Weeks, James
R. The prostaglandins: a family ofbiologically activelipids, 20, 1
Berkowitz, Barry. See Spector et al., 24, 191, See Spector et al., 25, 281
Berliner, David L., and Dougherty, Thomas F. Hepaticand extrahepatic regulation of corticosteroids, 13,
329Berliner, Robert W., and Orloff, Jack. Carbonic an-
hydrase inhibitors, 8, 137
Bertaccini, Giulio. Active polypeptides of nonmam-malian orgin, 28, 127
Bertler, A., Falck, B., Owman, Ch., and Rosengrenn,E. The localization of monoaminergic blood-brainbarrier mechanisms, 18, 369
Bertler, Ake, and Rosengren, Evald. Possible role ofbrain dopamine, 18, 769
Beutler, Ernest. Drug-induced hemolytic anemia, 21,73
Beyer, Karl H. Functional characteristics of renaltransport mechanisms, 2, 227
, and Baer, John E. Physiological basis for theaction of newer diuretic agents, 13, 517
Bickel, M. H. The pharmacology and biochemistry of
N-oxides, 21, 325
630 AUTHOR INDEX, VOLUMES 1-30
Bigelow, G., Griffiths, R., and Liebson, I. Experimental
human drug self-administration: methodology and
application to the study of sedative abuse, 27, 523
Bishop, Charles, and Talbott, John H. Uric acid: itsrole in biological processes and the influence uponit of physiological, pathological, and pharmacologi-cal agents, 5, 231
Bizzi, A. See Garattini and Bizzi, 18,243Bjur, R. See Weiner et al., 24, 203Blaschko, H. Amine oxidase and amine metabolism,
4, 415
-, Metabolism of epinephrine and norepinephrine,6, 23
, The development of current concepts of cate-cholamine formations, 11, 307
, Chairman. First Session, Section I: Enzymology,
18, 39-84; Introductory remarks, 39-, See Banks and Blaschko, 18,453Blinks, John R., and Koch-Weser, J. Physical factors
in the analysis of the actions of drugs on myocardial
contractility, 15, 531
, Prendergast, Franklyn G., and Allen, David G.
Photoproteins as biological calcium indicators,
28, 1
, See Koch-Weser and Blinks, 15,601Blohm, Thomas R Drug-induced lysosomal lipidosis:
biochemical interpretations, 30, 593
Bloom, Floyd E., Wedner, H. James, and Parker,Charles W. The use of antibodies to study cell
structure and metabolism, 25, 343Bobbin, Richard P. See Guth et al., 28, 95Bodansky, Oscar. Methemoglobinemia and methe-
moglobin-producing compounds, 3, 144Bohr, David F. Electrolytes and smooth muscle con-
traction, 16, 85
Bolender, Robert P. Morphometric analysis in theassessment of the response of the liver to drugs, 30,429
Borison, Herbert L., and Wang, S. C. Physiology andpharmacology of vomiting, 5, 193
Boullin, D. J. See Costa et al., 18, 577Bousquet, William F. See Newberne et al., 30, 335
Bowman, Robert L. Fluorescence and its measure-ment, 11, 256
Bowman, W. C., and Nott, M. W. Actions of sympa-thomimetic amines and their antagonists on skeletalmuscle, 21, 27
Boyd, Eldon M. Expectorants and respiratory tractfluid, 6, 521
Boyland, E. Mutagens, 6,345Brady, J. V. See Griffith et aL, 27,357Brand, J. J., and Perry, W. L M. Drugs used in motion
sickness. A critical review of the methods available
for the study of drugs of potential value in itstreatment and of the information which has beenderived by these methods, 18, 895
Braun-Menendez, E. Pharmacology of ream and hy-pertensin, 8, 25
Braunwald, Eugene. See Chidsey and Braunwald, 18,685
, See Higgins et al., 25, 119Brawley, Peter, and Duffield, James C. The pharma-
cology of hallucinogens, 24, 31Brendel, K. See Breeder et al., 21, 105Bresnick, Edward. Report on the discussion of the
Third Session, 25, 315Bressler, R., Corredor, C., and Brendel, K. Hypoglycin
and hypoglycin-like compounds, 21, 105Brestkin, A. P. See Kabachnik et aL, 22, 355
Brink, Frank. The role of calcium ions in neural pro-cesses, 6, 243
Brodie, Bernard B., Davies, J. I., Hynie, S., Krishna,G., and Weiss, B. Interrelationships of catechol-amines with other endocrine systems, 18, 273
-, Spector, Sydney, and Shore, Parkhurst A. Inter-action ofdrugs with norepinephrine in the brain, 11,548
-, See Costa et al., 18, 577Brody, Theodore M. The uncoupling of oxidative
phosphorylation as a mechanism of drug action, 7,335
-, Summary ofdiscussion and commentary, 18, 253
, See Akera and Brody, 29, 187Brownlee, George. The wider aspects of the chemo-
therapy of tuberculosis, 5, 421
Br#{252}cke, F. Dicholinesters ofa,�,-dicarboxylic acids and
related substances, 8, 265Bucher, K. Pathophysiology and pharmacology of
cough, 10, 43
Buchthal, Fritz. The effect of acetylcholine-like sub-stances on sensory receptors, 6, 97
Bueding, Ernest. Summary ofdiscussion and commen-tary, 18, 211
-, Batzinger, Robert P., Cha, Young-Nam, Talalay,Paul, and Molineaux, Christopher J. Protectionfrom mutagenic effects of antischistosomal and
other drugs, 30, 547�, and Swartzwelder, Clyde. Anthelmintics, 9, 329-, See Saz and Bueding, 18, 871Buffoni, F. Histaminase and related amine oxidases,
18, 163
Bunker, John P., Chairman, and Vandam, Leroy D.,
Co-chairman. Effects of anesthesia on metabolismand cellular functions: a workshop held under theCommittee on Anesthesia of the National Academy
of Sciences-National Research Council, 17, 183Burgen, A. S. V. Central and sensory transmission, 6,
95
Burn, J. H. Acetylcholine as a local hormone for ciliarymovement and the heart. 6, 107
-, Chairman. Section V: Adrenergic transmission,
18, 459-540; Introductory remarks, 459Burnstock, G. Evolution of the autonomic innervation
of visceral and cardiovascular systems in verte-
brates, 21, 248, Purinergic nerves, 24, 509
-, and Holinan, Mollie E. Junction potentials atadrenergic synapses, 18, 481
Bush, I. E. Chemical and biological factors in theactivity of adrenocortical steroids, 14, 317
AUTHOR INDEX, VOLUMES 1-30 631
Bushby, S. H. M. The chemotherapy ofleprosy, 10, 1Butcher, R. W. Cyclic 3’,S’-AMP and the lipolytic
effects of hormones on adipose tissue, 18, 237Butler, Thomas C. Theories of general anesthesia, 2,
121Butler, Vincent P., Jr. The immunological assay of
drugs, 29, 103-, Watson, John F., Schmidt, Donald H., Gardner,
Jerry D., Mandel, William J., and Skelton, C. Lynn.
Reversal of the pharmacological and toxic effects of
cardiac glycosides by specific antibodies, 25, 239
Cafruny, Edward J. The site and mechanism of actionof mercurial diuretics, 20, 89
Calabresi, Paul. Report on the discussion ofthe Fourth
Session, 25, 359Campbell, T. Cohn, and Hayes, Johnnie R. Role of
nutrition in the drug-metabolizing enzyme system,26, 171
Canaan, Lars A. Blood and tissue changes induced bynorepinephrine-stimulated mobilization offree fatty
acid, 18, 241
-‘ See Bergstrom et al., 20, 1Carbon, Loren D. The role of catecholamines in cold
adaptation, 18, 291Carlsson, Arvid. Detection and assay of dopamine, 11,
300
-, The occurrence, distribution, and physiological
role of catecholamines in the nervous system, 11,
490
-, Pharmacological depletion of catecholamine
stores, 18, 541
-, Kehr, W., Lindqvist, M., Magnusson, T. and
Atack, C. V. Regulation of monoamine metabolismin the central nervous system, 24, 371
Can, Edward A. Drug allergy, 6, 365
Case, Rosemary. Obituary, 18,6Catania, A. C. Drug effects and concurrent perfor-
mances, 27, 385Cha, Young-Nam. See Bueding et al., 30, 547Chenoweth, Maynard B. Monofluoroacetic acid and
related compounds, 1, 383-, Chelation as a mechanism of pharmacological
action, 8, 57, and McCarty, L. P. On the mechanisms of the
pharmacophoric effect of halogenation, 15, 673Chidsey, Charles A., and Braunwald, Eugene. Sym-
pathetic activity and neurotransmitter depletion in
congestive heart failure, 18, 685China, Herman I., and Smith, Paul K. Motion sick-
ness, 7, 33Christenson, James G. See Dairman et al., 24,266Clark, J. M., and Lambertsen, C. J. Pulmonary oxygen
toxicity: a review, 23, 39Clark, W. G. Studies on inhibition of L-dopa decarboz-
ylase in vitro and in vivo, 11, 330
Clarkson, T. W. See Passow et al., 13, 185Cloutier, G. See Weiner et al., 24, 203
Cluff, Leighton E. See Bennett and Cluff, 9, 427Code, Charles F. The inhibition of gastric secretion: a
review, 3, 59Cohen, Gerald. Techniques to improve the specificity
of the trihydroxyindole procedure, 11, 269Cole, Jonathan 0. See Kierman and Cole, 17, 101
Conney, A. H. Pharmacological implications of micro-somal enzyme induction, 19, 317
Cooper, Theodore. Surgical sympathectomy and ad-renergic function, 18, 611
Con, Carl, Chairman. Carbohydrate Metabolism, See-tion II: Metabolic Effects of Catecholamines, 18,
145-213
, See Helmreich and Cori, 18, 189Corredor, C. See Bressler et aL, 21, 105
Costa, E., Boullin, D. J., Hammer, W., Vogel, W., andBrodie, B. B. Interactions of drugs with adrenergicneurons, 18, 577
-, Green, A. R, Koslow, S. H., LeFevre, H. F.,
Revuelta, A. V., and Wang, C. Dopamine and nor-epinephrmne in noradrenergic axons: a study in vivo
oftheir precursor product relationship by mass frag-
mentography and radiochemistry, 24, 167Crout, J. Richard. Some spectrophotofluorimetric ob-
servations on blood and urine catecholamine assays,11, 296
, Pheochromocytoma, 18,651Curtis, D. R The pharmacology of central and periph-
eral inhibition, 15, 333, and Watkins, J. C. The pharmacology of amino
acids related to gamma-aminobutyric acid, 17, 347
Cuthbert, A. W. Membrane lipids and drug action, 19,
59
Dahlstr#{246}m, Annica. See Hillarp et al., 18, 727Dairman, Wallace, Christenson, James G., and Uden-
friend, Sidney. Changes in tyrosine hydroxylase anddopa decarboxylase induced by pharmacological
agents, 24, 266Dale, Sir Henry H. The beginnings and the prospects
of neurohumoral transmission, 6, 7Dalgaard-Mikkelsen, Sv., and Poulsen, Emil. Toxicol-
ogy of herbicides, 14, 225Daly, M. de Burgh. Acetylcholine and transmission at
chemoreceptors, 6, 79Dam, Henrik. Influence of antioxidants and redox
substances on signs of vitamin E deficiency, 9, 1Daniels-Severs, Anne E. See Severs and Daniels-Sev-
era, 25, 415
Danowski, T. S., and Elkinton, J. R. Exchanges of
potassium related to organs and systems, 3, 42Darken, Marjorie A. Puromycin inhibition of protein
synthesis, 16, 223Davies, B. N., and Withrington, P. G. The actions of
drugs on the smooth muscle of the capsule andblood vessels of the spleen, 25, 373
Davies, J. I. See Brodie et al., 18, 273Davis, Jean P. See Toman and Davis, 1, 425Dawes, G. S. Experimental cardiac arrhythmias and
quinidine-like drugs, 4,43de Champlain, Jacques. Report on the discussion of
the Fourth Session, 24, 431
632 AUTHOR INDEX, VOLUMES 1-30
DeLange, Robert J. See Krebs et al., 18, 163Delmonte, Lilian, and Jukes, Thomas H. Folic acid
antagonists in cancer chemotherapy, 14, 91De Matteis, F. Disturbances of liver porphyrin metab-
olism caused by drugs, 19, 523Dengler, Hans J. See Titus and Dengler, 18, 525
De Robertis, Eduardo. Adrenergic endings and vesi-des isolated from brain, 18, 413
de Wied, D. Chiorpromazine and endocrine function,19, 251
Dews, P. B. Introduction: Schedule-induced polydipsiaand oral intake of drugs, 27, 447
, Are the techniques and results of studies of self-administration of drugs useful in other areas of
psychobiology, 27, 545Diener, Robert M. See Newberne et al., 30, 335
Doak, George 0. See Eagle and Doak, 3, 107Domino, Edward F., Hardman, Harold F., and Seevers,
Maurice H. Central nervous system actions of somesynthetic tetrahydrocannabinol derivatives, 23, 317
, See Hardman et al., 23, 295Dontas, A. S. See Hoobler and Dontas, 5, 135Dorfman, Albert. Metabolism of the mucopolysaccha-
rides of connective tissue, 7, 1
Dornhorst, A. C. Adrenergic blockade in cardiovascu-lar disease, 18, 701
Dougherty, Thomas F. See Berliner and Dougherty,
13, 329
Douglas, W. W. Is there chemical transmission at
chemoreceptors?, 6, 81
, The mechanism of release of catecholaminesfrom the adrenal medulla, 18, 471
Downs, D. A., and Woods, J. H. Naloxone as a negativereinforcer in rhesus monkeys: effects of dose, sched-
ule, and narcotic regimen, 27, 397Drill, Victor A. Hepatotoxic agents: mechanism of
action and dietary interrelationship, 4, 1Duncan, Leslie J. P., and Baird, Joyce D. Compounds
administered orally in the treatment of diabetesmellitus, 12, 91
Duffield, James C. See Brawley and Duffield 24, 31Dustin, P., Jr. New aspects of the pharmacology of
antimitotic agents, 15, 449
Dyrenfurth, I. See Vande Wiele and Dyrenfurth, 25,
189
Eagle, Harry, and Doak, George 0. The biologicalactivity of arsenosobenzenes in relation to their
structure, 3, 107Edvinsson, Lars, and MacKenzie, Eric T. Amine mech-
anisms in the cerebral circulation, 28, 275
Ehrenpreis, Seymour, Fleisch, Jerome H., and Mittag,
Thomas W. Approaches to the molecular nature ofpharmacological receptors, 21, 131
Eldjarn, Lorentz. See Pihi and Eldjarn, 10, 437Elion, G. B. See Hitchings and Elion, 15, 365
Elkinton, J. R. See Danowski and Elkinton, 3, 42Ellis, Sydney. The metabolic effects of epinephrine
and related amines, 8, 485
, Relation of biochemical effects of epinephrine to
its muscular effects, 11, 469Elmadjian, Fred. Excretion and metabolism of epi-
nephrmne, 11, 409
Emmelin, N. Supersensitivity following “pharmaco-
logical denervation,” 13, 17Engbaeck, Lisa. The pharmacological actions of mag-
nesium ions with particular reference to the neuro-
muscular and the cardiovascular system, 4, 396
Er#{228}nk#{246},Olavi. Demonstration of catecholamines andcholinesterases in the same section, 18, 353
Erlanger, Bernard F. Principles and methods for the
preparation of drug protein conjugates for immu-nological studies, 25, 271
Erspamer, V. Pharmacology of indoleakylamines, 6,
425
Exton, J. H., and Park, C. H. The stimulation of
gluconeogenesis from lactate by epinephrine, glu-
cagon, and cyclic 3’,5’-adenylate in the perfused ratliver, 18, 181
Fain, John N. Biochemical aspects of drug and hor-
mone action on adipose tissue, 25, 67Fairhurst, Alan S. See Jenden and Fairhurst, 21, 1Falck, B. See Bertler et al., 18, 369
Falk, J. L., and Samson, H. H. Schedule-induced phys-ical dependence on ethanol, 27, 449
F#{228}nge,H. Pharmacology ofpoikilothermic vertebratesand invertebrates, 14, 281
Fastier, F. N. Structure-activity relationships of aim-dine derivatives, 14, 37
Featherstone, H. M., and Muehlbaecher, C. A. The
current role of inert gases in the search for anesthe-
sia mechanisms, 15, 97Feldberg, W. S. Central and sensory transmission, 6,
85Feldberg, W., Chairman. Section VIII: Adrenergic
Mechanisms in the Nervous System, 18, 713-803Introductory remarks, 713
Fischbach, Gerald D., Frank, Eric, Jessell, ThomasM., Rubin, Lee L., and Schuetze, Stephen M. Ac-cumulation of acetyicholine receptors and acetyl-
cholinesterase at newly formed nerve-muscle syn-
apses, 30, 411Fisher, James W. Erythropoietin: pharmacology, bio-
genesis, and control of production, 24, 459Fleisch, Jerome, H. See Ehrenpreis et al., 21, 131Flesch, P. Inhibition of keratinizing structures by sys-
temic drugs, 15, 653Flower, Roderick J. Drugs which inhibit prostaglandin
biosynthesis, 26, 33
Flynn, Edward J. See Spector et al., 25, 281Forney, Robert B. Toxicology of marihuana, 23, 279
Fox, B. N., and Fox, Margaret. Biochemical aspects ofthe actions of drugs on spermatogenesis, 19, 21
Fox, Margaret. See Fox, B. N., and Fox, Margaret, 19,21
Frank, Eric. See Fischbach et al., 30, 411Franklin, Edward C. Report on the discussion of the
Second Session, 25, 269
Fraser, H. F. See Isbell and Fraser, 2, 355
AUTHOR INDEX, VOLUMES 1-30 633
Freedman, Daniel X. See Giarman and Freedman, 17,
1
French, J. E. See Robinson and French, 12, 241Freyburger, Walter A. See Moe and Freyburger, 2, 61Friedenwald, Jonas S. Histochemistry-a review, 7,83
Friedman, Stanley. See Kaufman and Friedman, 17,71
Furchgott, Robert F. The pharmacology of vascularsmooth muscle, 7, 183
-, The receptors for epinephrine and norepineph-
rime (adrenergic receptors), 11, 429
-, Summary ofdiscussion and commentary, 18,641Fuxe, Kjell. See Goldstein et a!., 24, 293
-, See Hillarp et al., 18, 727
Gaddum, Sir John H. Bioassays and mathematics, 5,87
-, Theories of drug antagonism, 9, 211-, Bioassay procedures, 11, 241
, Obituary, 18, 5Gale, E. F. Mechanisms of antibiotic action, 15, 481Garattini, S., and Bizzi, A. Effect of drugs on mobili-
zation of free fatty acid, 18, 243
Gardner, Jerry D. See Butler et al., 25, 239Gavin, J. R., III. See Gorden et al., 25, 179Gerard, R. W. Closing remarks to symposium on neu-
rohumoral transmission, 6, 123Germuth, Frederick G., Jr. The role of adrenocortical
steroids in infection, immunity, and hypersensitiv-ity, 8, 1
Giarman, Nicholas J., and Freedman, Daniel X. Bio-chemical aspects of the actions of psychotomimetic
drugs, 17, 1
Gibbins, R. J� See Kalant et al., 23, 135
Gill, C. A. See Holz and Gill, 27, 437
Gillespie, J. S. Summary of discussion and commen-
tary, 18, 537Gilman, Alfred, and Koelle, G. B. Anticholinesterase
drugs, 1, 166
Ginsborg, B. L. Ion movements in junctional traits-mission, 19, 289
Gitlow, S. E. Summary ofdiscussion and commentary,18, 707
Glaval, E. See Nikodijevi#{233} et a!., 18, 705Glick, Seymour M. Report on the discussion of the
First Session, 25, 209Glowmski, J., and Axelrod, J. Effects of drugs on the
disposition of H3-norepinephrmne in the rat brain,
18, 775
Glowinski, Jacques, and Baldessarini, Ross J. Metab-
olism of norepinephrine in the central nervous sys-
tern, 18, 1201
Glynn, I. M. The action of cardiac glycosides on ionmovements, 16, 381
Godovikov, N. N. See Kabachnik et al., 22, 355
Goffart, M. The action of l-noradrenaline and adre-nochrome on unfatigued mammalian muscle, 6, 33
Golberg, Leon. Keynote Address. Toxicology: Has anew era dawned?, 30, 351
Goldberg, Leon I. Cardiovascular and renal actions of
dopamine: potential clinical applications, 24, 1
Goldberg, S. R. Stimuli associated with drug injectionsas events that control behavior, 27, 325
, and Kelleher, R. T. Introduction: schedules oftermination of drug injections, 27, 395
, See Kelleher and Goldberg, 27, 291, 341
Goldfien, Alan. Effects of glucose deprivation on the
sympathetic outflow to the adrenal medulla and
adipose tissue, 18, 303
Goldstein, Avram. Interactions of drugs and plasma
proteins, 1, 102
Goldstein, M. Inhibition of norepinephrine biosyn-thesis at the dopamine-$-hydroxylation stage, 18,
77, Fuxe, K., and H#{246}kfelt, T. Characterization and
tissue localization ofcatecholamine synthesizing en-
zymes, 24, 293
Goodall, McC. Metabolic products of adrenaline andnoradrenaline in human urine, 11, 416
Goodenough, Daniel A. Gap junction dynamics andintercellular communication, 30, 383
Gorden, P., Gavin, J. R., ifi, Kahn, C. R., Archer, J.A., Lesniak, M., Hendricks, C., Neville, D. M., Jr.,and Roth, J. Application of radioreceptor assay to
circulating insulin, growth hormone, and to theirtissue receptors in animals and man, 25, 179
Gorkin, V. Z. Monoamine oxidases, 18, 115Goz, Barry. The effects of incorporation of 5-haloge-
nated deoxyuridines into the DNA of eukaryotic
cells, 29, 249
Graessle, Otto E. See Molitor and Graessle, 2, 1Grant, W. Morton. Physiological and pharmacological
influences upon intraocular pressure, 7, 143Gray, Jack E. See Newberne et al., 30, 335
Green, A. R. See Costa et al., 24, 167Griffith, R. R., Wurster, R. M., and Brady, J. V.
Discrete-trial choice procedure: effects of naloxoneand methadone on choice between food and heroin,27, 357
Griffiths, R. See Bigelow et al., 27, 523Grub, Mary A. Electron microscopy of sympathetic
tissues, 18, 387Guldberg, Hans C., and Marsden, Charles A. Catechol-
0-methyl transferase. Pharmacological aspects and
physiological role, 27, 135
Gunnison, Janet B. See Jawetz and Gunnison, 5, 175Guth, Paul S., Norris, Charles H., and Bobbin, Richard
P. The pharmacology of transmission in the periph-
eral auditory system, 28, 95
Gyermek, Laszlo. 5-Hydroxytryptamine antagonists,
13, 399
Haag, H. B. See Silvette et al., 14, 137Haber, Edgar, Chairman. Cardiovascular Applica-
tions, The role of antibodies and physiological re-
ceptors in cardiovascular diagnosis, therapy, andresearch, 25, 215
-, See Smith, T. W., and Haber, 25, 219Haddy, Francis J. See Visscher et aL, 8, 389
Hagen, P. The storage and release of catecholamines,
634 AUTHOR INDEX, VOLUMES 1-30
11, 361
Haggendal, Jan. Newer developments in catechol-
amine assay, 18, 325
Hahn, F. Analeptics, 12, 447
Hajdu, Stephen, and Leonard, Edward. The cellularbasis of cardiac glycoside action, 11, 173
Hammer, W. See Costa et al., 18, 577Hansen, Eder L. See Anderson and Hansen, 2, 399Hardman, Harold F., Domino, Edward F., and Seevers,
Maurice H. General pharmacological actions of
some synthetic tetrahydrocannabinol derivatives,23, 295
-, See Domino et al., 23, 317Hartman, Boyd K., and Udenfriend, Sidney. The ap-
plication of immunological techniques to the studyof enzymes regulating catecholamine synthesis and
degradation, 24, 311Harris, Louis S. General and behavioral pharmacol-
ogy, 23, 285
Hasselbach, Wilhelm, and Weber, Annemarie. Models
for the study of the contraction of muscle and of cell
protoplasm, 7, 97Haugaard, Niels, and Hess, Marilyn E. Actions of
autonomic drugs on phosphorylase activity andfunction, 17, 27
-, and Hess, Marilyn E. The influence of catechol-amines on heart function and phosphorylase activ-
ity, 18, 197
-, Kukovetz, Walther R., and Hess, Marilyn E. The
effect ofsympathomimetic amines on phosphorylaseactivity of the isolated rat heart, 11, 466
Hawking, Frank. The chemotherapy of filarial infec-
tions, 7, 279Hawkins, Rosemary D. The metabolism of ethanol
and its metabolic effects, 24, 67Hayaishi, Osamu. Enzymic studies on the mechanism
of double hydroxylation, 18, 71Hayes, Johnnie R. See Campbell and Hayes, 26, 171
Hebb, Catherine 0. Acetylcholine metabolism of ner-vous tissue, 6, 39
Heinle, Robert W. See Welch and Heinle, 3, 345Hellon, R. F. Monoamines, pyrogens, and cations:
their action on central control of body temperature,
26, 289
Helmreich, Ernst, and Cori, Carl F. The activation ofglycolysis in frog sartorius muscle by epinephrine,18, 189
Hendricks, C. See Gorden et al., 25, 179
Hertz, Leif. Drug-induced alterations of ion distribu-tion at the cellular level of the central nervous
system, 29, 35Hess, Marilyn E. See Haug#{225}ard and Hess, 17,27
-‘ See Haugaard and Hess, 18, 197, See Haugaard et al., 11, 466
Heymans, C. Action of drugs on carotid body andsinus, 7, 119
Higgins, Charles B., Vatner, Stephen F., and Braun-wald, Eugene. Parasympathetic control ofthe heart,
25, 119
Hillarp, Nils-Ake. Obituary, 18, 5
-, Fuxe, Kjell, and Dahlstrdm, Annica. Demonstra-
tion and mapping of central neurons containing
dopamine, noradrenaline, and 5-hydroxytryptamineand their reactions to psychopharmaca, 18, 727
Himms-Hagen, Jean. Sympathetic regulation of me-
tabolism, 19, 367
Hitchings, G. H., and Elion, G. B. Chemical suppres-sion of the immune response, 15, 365
Hoff, E. C. See Silvette et al., 14, 137Hoffmeister, F., and Wuttke, W. Psychotropic drugs
as negative reinforcers, 27, 419
H#{246}kfelt, T. See Goldstein et al., 24, 293Hollenberg, Morley D. Hormone receptor interactions
at the cell membrane, 30, 393Hollister, Leo E. Actions of various marihuana deriv-
atives in man, 23, 349
Holman, Mollie E. See Burnstock and Holman, 18,481
Holmstedt, Ba. The action of anticholinesterases on
spinal reflexes following intraarterial injection, 6,49
, Pharmacology of organophosphorus cholinester-
ass inhibitors, 11, 567Holtz, Peter. Role of L-dopa decarboxylase in the
biosynthesis of catecholamines in nervous tissue andthe adrenal medulla, 11, 317
, Chairman. Second Session, Section I: Enzymol-ogy, 18, 85-144; Introductory remarks, 85
-, and Palm, Dieter. Pharmacological aspects of
vitamin B�, 16, 113
Holz, W. C., and Gill, C. A. Drug injections as negativereinforcers, 27, 437
Hoobler, S. W., and Dontas, A. S. Drug treatment of
hypertension, 5, 135Hornykiewicz, Oleh. Dopamine (3-hydroxytyramine)
and brain function, 18, 925Horowicz, Paul. The effects of anions on excitable
cells, 16, 193
Hottendorf, G. H. See Newberne et al., 30, 335
Hug, George. Pro- and postnatal pathology, enzymetreatment, and unresolved issues in five lysosomaldisorders, 30, 565
Hull, R See Hurst and Hull, 8,199Hunt, Carlton C., and Kuffler, Stephen W. Pharma-
cology of the neuromuscular junction, 2, 96Hunter, F. Edmund, Jr., and Lowry, Oliver H. The
effects of drugs on enzyme systems, 8, 89Hurst, E. Weston, and Hull, R. The chemotherapy of
virus diseases, with brief consideration of the influ-
ence of dietary, hormonal, and other factors in virusinfection, 8, 199
Hynie, S. See Brodie et al., 18, 273
Iglauer, C., Liewellyn, M. E., and Woods, J. H. Currentschedules of cocaine injection in rhesus monkeys:
dose variation under independent and non-indepen-dent variable-interval procedures, 27, 367
Ingram, G. I. C. Anticoagulant therapy, 13, 279Isbell, Harris, Chairman. Marihuana and Its Surro-
gates, Session II, 23, 337-380Clinical pharmacology of marihuana, 337
AUTHOR INDEX, VOLUMES 1-30 635
-, and Fraser, H. F. Addiction to analgesics andbarbiturates, 2, 355
Jackson, H. Antifertility substances, 11, 135Jacobowitz, David W. See Kostrzewa and Jacobowitz,
26, 199
Jacobsen, Erik. The metabolism of ethyl alcohol, 4,107
Jawetz, Ernest, and Gunnison, Janet B. Antibioticsynergism and antagonism: an assessment of theproblem, 5, 175
Jenden, Donald J., and Fairhurst, Alan S. The phar-macology of ryanodine, 21, 1
Jensen, Elwood V. Interaction of steroid hormoneswith the nucleus, 30, 477
Jessell, Thomas M. See Fischbach et al., 30, 411Johanson, C. E. Pharmacological and environmental
variables affecting drug preference in rhesus mon-
keys, 27, 343
Johanseon, B#{246}rje.See Meliander and Johansson, 20,117
Johns, Anthony. See Paton et al., 29, 67Jones, Reese T. Marihuana-induced “high”: influence
of expectation, setting, and previous drug experi-ence, 23, 359
Jukes, Thomas H., and Williams, William L. Nutri-tional effects of antibiotics, 5,381
-‘ See Delmonte and Jukes, 14, 91
Kabachnik, M. I., Brestkin, A. P., Godovikov, N. N.,Michelson, M. J., Rozengart, E. V., and Rozengart,
V. I. Hydrophobic areas on the active surface ofcholinesterases, 22, 355
Kahn, C. R. See Gorden et al., 25, 179Kalant, H., LeBlanc, A. E., and Gibbins, R J. Toler-
ance to, and dependence on some non-opiate psy-chotropic drugs, 23, 135
Kao, C. Y. Tetrodotoxin, saxitoxin, and their signifi-
cance in the study of excitation phenomena, 18,997Kappas, A., and Palmer, R. H. Selected aspects of
steroid pharmacology, 15, 123Karlson, Peter. See Sekeris and Karlson, 18, 89
K#{227}ser,Hans. Catecholamine-producing neural tumorsother than pheochromocytoma, 18, 659
Kaufman, Seymour. Coenzymes and hydroxylases:ascorbate and dopamine-fl-hydroxylase; tetrahy-dropteridines and phenylalanine and tyrosine hy-droxylases, 18, 61
-, and Friedman, Stanley. Dopamine-/1-hydroxyl-ass, 17, 71
Kehr, W. See Carlsson et al., 24, 371Kelleher, R. T. Characteristics of behavior controlled
by scheduled injections of drugs, 27,307
-‘ and Goldberg, S. R. General introduction: controlof drug-taking behavior by schedules of reinforce-
ment, 27, 291
-‘ and Goldberg, S. R. Introduction: Complexschedules of drug injection, 27, 341
-, See Goldberg and Kelleher, 27, 395Kemp, Robert G. See Krebs et al., 18, 163
Kety, Seymour S. The theory and applications of the
exchange of inert gas at the lungs and tissues, 3, 1
-, Central actions of catecholamines, a discussion,11, 565
-, Catecholamines in neuropsychiatric states, 18,787
-, Chairman. First Session, Increased Synthesis ofCatecholamines without Changes in Enzyme Levels,24, 167-224
Khromov-Borisov, N. V., and Michelson, M. J. Themutual disposition of cholinoreceptors of locomotor
muscles, and the changes in their disposition in the
course of evolution, 18, 1051
Kiese, Manfred. The biochemical production of fern-hemoglobin-forming derivatives from aromatic
amines, and mechanisms of ferrihemoglobin forms-tion, 18, 1091
Killam, Eva King. Drug action on the brain-stemreticular formation, 14, 175
Kimura, Kazuo K. See Randall and Kimura, 7, 365Kiplinger, Glenn F., and Manno, Joseph E. Dose-re-
spouse relationships to cannabis in human subjects,23, 339
Kirshner, Norman. Biosynthesis of adrenaline andnoradrenaline, 11, 350
-, Summary of discussion and commentary, 18, 83-, and Viveros, 0. H. The secretory cycle in the
adrenal medulla, 24, 385Kizer, John S., Youngbbood, William W., and Nemer-
off, Charles B. Neurotoxic amino acids and struc-turally related analogs, 29, 301
Klaus, Wolfgang. See Lee and Klaus, 23, 193Klerman, Gerald L, and Cole, Jonathan 0. Clinical
pharmacology of imipramine and related antide-
pressant compounds, 17, 101Koch-Weser, J., and Blinks, J. R. The influence of the
interval between beats on myocardial contractility,
15, 601
, See Blinks and Koch-Weser, 15,531Koelle, George B. The localization of specific cholin-
esterase in the retina, 6, 47-, Possible mechanisms for the termination of the
physiological actions of cateeholamines, 11, 381-, Summary of discussion and commentary, 18,359
-, See Gilman and Koelle, 1,166Kopin, Irwin J. Storage and metabolism of catechol-
amines: the role of monoamine oxidase, 16, 179-, Biochemical aspects ofrelease of norepinephrine
and other amines from sympathetic nerve endings,18, 513
-, and Silberstein, Stephen D. Axons of sympa-thetic neurons: transport of enzymes in viva andproperties of axonal sprouts in vitro, 24, 245
-‘ See Lemberger et al., 23, 371Koslow, S. H. See Costa et al., 24, 167Kosterlitz, H. W., and Lees, G. M. Pharmacological
analysis of intrinsic intestinal reflexes, 16,301Kostrzewa, Richard M., and Jacobowitz, David W.
Pharmacological actions of6-hydroxydopamine, 26,199
636 AUTHOR INDEX, VOLUMES 1-30
Krasnegor, N. A. Introduction: behavioral factors in
human drug abuse, 27,499Krebs, Edwin G., DeLange, Robert L, Kemp, Robert
G., and Riley, W. Dixon. Activation ofskeletal mus-cle phosphorylase, 18, 163
Krishna, G. See Brodie et al., 18, 273Krsti#{233},M. See Varagl#{233} and Krsti#{233},18,799Kuffler, Stephen W. See Hurtt and Kuffler, 2,96Kukovetz, Walther R. See Haugaard et al., 11,466
Laemmli, U. K. Levels of organization of the DNA in
eucaryotic chromosomes, 30, 469Lambertsen, C. J. See Clark and Lambertsen, 23,39
Lande, Saul, and Lerner, Aaron B. The biochemistryof melanotropic agents, 19, 1
Lands, A. M. The pharmacological activity of epineph-rune and related dihydroxyphenylalkylamines, 1, 279
Larson, P. 5. See Silvette et al., 14, 137
Larsson, Stig. See Andersson and Larsson, 13, 1Lasagna, Louis. The clinical evaluation of morphine
and its substitutes as analgesics, 16, 47Laties, Victor G. See Weiss and Laties, 14, 1
Latt, Samuel A., Schreck, Rhona R., Loveday, Ken-neth S., and Shuler, Charles F. In vitro and in vivo
analysis of sister chromatid exchange, 30, 501Lurell, C.-B. Plasma iron and the transport of iron in
the organism, 4, 371Leander, J. D., and McMillan, D. E. Schedule-induced
narcotic ingestion, 27, 475
LeBlanc, A. E. See Kalant et al., 23, 135Lee, Kwang S., and Klaus, Wolfgang. The subcellular
basis for the mechanism of inotropic action of car-
disc glycosides, 23, 193Leeper, Lemuel C. Catecholamine formation in intact
tissues, 11, 358
Lees, G. M. See Kosterlitz and Lees, 16,301
LeFevre, H. F. See Costa et aL, 24, 167LeFevre, Paul G. Sugar transport in the red blood cell:
structure-activity relationships in substrates and an-
tagonists, 13, 39
Letkowitz, Robert J. Isolated beta-adrenergic binding
sites: a potential assay vehicle for catecholamines,25, 259
Lemberger, Louis, Axelrod, Julius, and Kopin, IrwinJ. Metabolism and disposition of �9-tetrahydrocan-nabinol in man, 23, 371
Leonard, Edward. See Hajdu and Leonard, 11, 173Lerner, Aaron B. See Lande and Lerner, 19, 1Lesniak, M. See Gorden et al., 25, 179Levi-Montalcini, Rita, and Angeletti, Piero U. Immu-
nosympathectomy, 18, 619
Levine, Lawrence. Antibodies to pharmacologicallyactive molecules: specificities and some applicationsof antiprostaglandins, 25,293
Lieberman, Seymour, and Teich, Sylvia. Recent trends
in the biochemistry of the steroid hormones, 5, 285Liebson, I. See Bigelow et aL, 27, 523
Lilienthal, Joseph L., Jr. Carbon monoxide, 2, 324Liljestrand, G. Transmission at chemoreceptors, 6,73
Lindenbaum, John. Bioavailability of digoxin tablets,
25, 229
Lindenmayer, George E. See Schwartz et al., 27, 3Lindqvist, M. See Carlsson et al., 24, 371
Llewellyn, M. E. See Iglauer et aL, 27, 367Loewe, S. Antagonism and antagonists, 9, 237Loewi, Otto. Introduction to symposium on neurohu-
moral transmission, 6, 3Longo, V. G. Behavioral and electroencephalographic
effects of atropine and related compounds, 18, 965Loveday, Kenneth S. See Latt et aL, 30, 501
Lowry, Oliver H. See Hunter and Lowry, 8,89Lundholm, Lennart, Chairman. Physiological Interre-
lationships, Section II: Metabolic Effects of Cate-cholamines, 18, 255-314; Introductory remarks, 255
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