View
220
Download
1
Tags:
Embed Size (px)
Citation preview
IR-4 Laboratory Vision Statement
To Provide High-Quality Residue Data for Incorporation into IR-4 Petitions for Minor-Use Registrations
New Challenges
Recover the Data Output Lost by the Closing of the Northeast Residue Laboratory Average of 2-3 More Studies (17 Field Trials) /
Lab Merge into a Floating 30-Month Timeline
Match Industry Submission Time-Tables Coordinate with EPA Petition Review Time-Slots Coordinate with Bundled Project Submissions
Objectives
Increase Residue Data Reporting Output
Incorporate Time-Line Flexibility into the Completion of the Residue Phase of IR-4 Studies
Maintain the Current Quality Level of the IR-4 Laboratory Data
Methods
Enforcement Methods are Getting More Complex
IR-4 Studies More Involved MS/MS Methods Increasingly the
Norm
Space
Freezer Space Limited Capacity Running Out in Some Labs
Laboratory Space Fume Hoods Bench Space
Operating Funds
Not Mentioned as a Problem by All Labs
Supply and Service Contract Costs Rise Annually
Equipment
Changing Technology Obsolescence
- Nearing or at end of lifespan for manufacturer support - Reaching limits of sensitivity
Today’s SituationWhat Do We Have Inventory of Instrumentation and
Other High-End Laboratory Equipment (Addendum to this Presentation)
Summary
Current InstrumentationNumber of…. NCR SR WR BER TIR YAR
HPLCs MS/MS 2 2 4 1 1 1
Other 2 1 - 2 - 1
GCsMS/MS - - - - - -
MS or MSD 2 2 2 1 1 1
Other 2 3 3 2 2 3
High-End Equipment & Services All Labs Have Costly ($10-50K) Process-Related
Equipment and Services. These include… Accelerated Solvent Extractors Gel Permeation Chromatography Systems Food Choppers Rotor/Stator Homogenizers Analytical Balances Refrigerated Centrifuges High Purity N2 Generators (req'd. for HPLC-MS/MS systems) High Purity Oil-Free Air Compressors (also for HPLC-MS/MS systems) High Efficiency Rotary and Multi-position Evaporators Instrument Service Contracts ($15-20K/year/instrument for HPLC-MS/MS)
TomorrowWhat Do We Need to…
Maintain Current Levels of Output
Increase Output Levels
* = Priority Items
North Central Region Lab
* Additional HPLC-MS/MS GC-MS/MS Additional Bench Chemist / Analyst Standardization of Procedures
Throughout All Studies
Southern Region Lab
* Additional HPLC-MS/MS * Upgrade of GC/MS instruments * Additional GC-MS/MS 2 New Rotary Evaporators New Analytical Balance
Western Region Lab
* Additional HPLC-MS/MS (Agilent 6430)
* SPEX Geno-Grinder Additional GC-MS/MS (Agilent)
ARS Lab – Beltsville, MD
* HPLC-MS/MS (Waters or Thermo)* GC-MS/MS (Thermo)Operating FundsAdditional Bench Chemist/Analyst
Instrumentation:What Will It Cost? New Research-Grade HPLC-MS/MS
($250-300K each) New Research-Grade GC-MS/MS
($200-240K) Other Needs
(< $50K)
How to Meet these Costs
PMC Leveraging / Lobbying Power At IR-4 Headquarters
Stream-Lining the Size of Studies Standardizing Procedures and Forms Funding Increases
Congress/USDA-NPS Appropriations Level
PMC-Supported Funding
Recommendations For Instrumentation Purchases New, Used, Refurbished Equipment
All can be Financed or Leased GSA Pricing Multiple Instrument ‘Purchasing’ for All
Programs
Instrument Leasing Programs Lease to Own (~$100K/Instrument/Year) Operating Lease (~$40K/Instrument/Year)
Operating Lease
Renting for 3-5 years w/ the option to… Return Instrument and Owe Nothing
Keep Instrument and Buyout Lease for the Fair Market Value (FMV) of the Instrument
Keep Instrument and Finance the FMV in Another Lease
Key to Symbols
Still Working Reliably No Longer Reliable Unsupported by Manufacturer for Service Parts Limited or Unavailable from the
Manufacturer
PM = Preventative Maintenance
North Central Region Lab - HPLC
Waters MS/MS (2006)
Thermo-Finnigan MS/MS
(2002) (PM only)
Waters vwUVD (2000) (PM only)
Waters vwUVD(pre-2000)
(PM only)
North Central Region Lab - GC
Agilent MS (2004)
Agilent MS (2001) (PM only)
Agilent ECD/FPD(pre-2000)
Agilent NPD/FPD(pre-2000)
North Central Region Lab
High-End Equipment Dionex ASE 200 (pre-2000) Peak Scientific Nitrogen Generator
(2007)
Southern Region Lab - HPLC
Thermo TSQ Ultra MS/MS
(2006)
Thermo TSQ MS/MS (2002)
Hitachi Binary Pump Syst. with Dual vwUVD
(pre-1999)
Southern Region Lab - GC
HP 5890 II NPD/ECD(2005used
) (soon)
Agilent 6890/5973 EI MSD (1999) (software out of
date)
Agilent 6890/5973 EI/CE MSD
(1998) (software out of
date)
Agilent 6890 NPD/µECD (1998)
PerkinElmer Auto NPD/FPD (1995)
Southern Region Lab
High-End Equipment RobotCoupe Food Processors, 10 & 23
qt (2009) 6 Omni Homogenizers (10-20 yrs old)
Rotor/Stator Blender (2006)
Western Region Lab - HPLC
Agilent 6430 MS/MS
(2009)
Agilent 6410B MS/MS
(2007)
2 Applied Biosystems API-2000 MS/MS
(1999 & 2000, one unit at
WSU)
(sensitivity an issue)
Western Region Lab - GC
Agilent 6890/5975B MSD
(2006)
3 Agilent 6890/5973 MSD
(1997, 1998 & 2004)
3 HP 5890s(mid 1980s to early 1990s)
Western Region Lab
High-End Equipment Caliper Prelude GPC System (2003)
(software)
Labconco Rapid Vac System (2009) Zymark TurboVap Workstation
(~1993)
ARS Lab – Beltsville, MD - HPLC
Waters 2695 PCR/FLD/PDA
(2007)
Waters 2695/Micromass Quattro Ultima MS/MS
(2001) (soon)
Agilent 1050 FLD/vwUVD (1997)
ARS Lab – Beltsville, MD - GC
Agilent 6890N NPD/FPD
(2005)
Shimadzu GC17/QP5050A MS
(2004) (software)
HP 5890 II NPD/ECD (1992)
ARS Lab – Beltsville, MD
High-End Equipment AtlasCopco SF8FF Air Compressor (2005) ParkerHannifin NP2010 Nitrogen Generator
(2001) Büchi Syncore Polyvap-Reactor Multi-
Sample Evaporation / Reaction Module (2008)
2 Heidolf Laborata 4001 High-Efficiency REs (2007)
ARS Lab – Tifton, GA - GC
Agilent 6890 – ECD/MSD(2001)
Agilent 6890 – NPD/FPD(2001)
Perkin Elmer Auto ECD/NPD
(1993)
ARS Lab – Wapato, WA - HPLC
Applied Biosystems API-2000 MS/MS
(2003) (operational status and sensitivity unreliable)
Agilent 1100 (1999)
ARS Lab – Wapato, WA - GC
3 Agilent 6890s(1999-2001)
(software)
Agilent 5973 MSD
(1999) (questionable for near long-term)