In This Issue bull Software Updatesbull Upcoming Conferences

bull Employee Spotlight

bull Recent Publicationsbull Surgery Tipbull Technical Question

Surgery TipA vital component to a successful

animal surgery is providing the

animal with proper postshysurgery

care To promote healthy

recovery Pinnacle advises waiting

5shy7 days before beginning

experiments This includes

attempting to plug in a headstage

or preamplifier into the animalrsquos

EEGEMG headmount or inserting

a biosensor into a cannula When

housing animals after surgery

ensure there is enough clearance

from the head of the animal to the

top of the cage or other fixtures or

apertures that might be present in

the home cage

While Pinnacle recommends the

above postshysurgery tips animal

surgeons should always defer to

their institutionrsquos IACUC or animal

care committee for proper animal

care procedures

Technical QuestionHow can I improve the

Itrsquos spring in Kansas which means flowers cleanup gardening and rapidly

changing weather With one eye on the sky we are excited to be

showcasing our wireless EEG products at the APSS Sleep Meeting in Seattle

and our continuous glucose monitoring system at the American Diabetes

Association Scientific Sessions in Boston We hope to have the opportunity

to meet with you at either conference

If you have any suggestions for new products mdash or improvements to our

existing products and software mdash we would love to hear from you We are

currently engaged in further developing our optogenetics systems new and

varied biosensors and enzymes and systems to allow a range of behavioral

and physiological measurements to be made with rats and mice housed in

groups

I hope you all are having a wonderful new season regardless of where you

are in the world

All the best

Donna A Johnson President and CEO

Software Updates The team at Pinnacle Technology is continually working to improve its

products and is happy to announce the release of an updated version of its

Sireniareg and Sleep Deprivation software

Sireniareg Version 172 has added features for exporting video to AVI files

within its free base package while its paid components (Seizure Pro Sleep

Pro and XshyY Tracking) now offer additional image and print options for data

plots Bug fixes were also made across all Sireniareg software to improve

quality of my animal videorecordings One simple trick to improve video

quality would be to increase the

amount of white light surrounding

the cage area For night or lowshy

light situations an IR source can

provide the illumination needed to

successfully record animal

behavior If you have purchased

Pinnacles box camera or HD

camera try adjusting the focus

lens to allow more light into the

camera

In addition to adjusting the

hardware settings on the camera

itself you can adjust settings in

Sireniareg software to improve your

recordings For your video

compression settings Pinnacle

recommends using the MJPG

option To improve the recorded

frame rate of your video

recordings you can chose to

record video at a lower resolution

or select the greyscale option

Additional information is located in

the Sireniareg Synchronized Video

manual For an electronic copy of

the latest version of the

video manual contact a Pinnacle

representative at 785shy832shy8866 or

salespinnacletcom

Call for PostersMany Pinnacle customers regularly

present their scientific work at

conferences and meetings

throughout the year We would

love to share your research with

other users of our products and

systems Please help us continue

to advance neuroshyphysiological

studies by allowing us to host your

previously presented posters on

our website We will increase the

visibility and impact of your

usability

Sleep Deprivation software has now been upgraded to Sireniareg Feedback

Pro This new program enables users to create rulesets based on EEGEMG

thresholds baseline data and power analysis to initiate stimuli in a variety of

sleep seizure optogenetics and other paradigms

A complete list of updates is available on our LinkedIn Product Forum Join

the forum to stay up to date on software releases industry developments

and other Pinnacle news

Upcoming ConferencesConferences are just around the corner Be sure to keep an eye out for

Pinnacle representatives at the following events

ADA 75TH SCIENTIFIC SESSIONS

June 5shy9 in Boston Mass

Booth 1157

APSS SLEEP MEETING 2015

June 6shy10 in Seattle Wash

Booth 1024

MEETING OF THE JAPAN NEUROSCIENCE SOCIETY

JuLY 28shy31 in Kobe Japan

In conjunction with Neuroscience Inc of Tokyo

Employee SpotlightSeth Gabbert For senior design engineer Seth

Gabbert a career at Pinnacle

Technology was a dream hellip Or maybe

something that came to him in a dream

as he dozed off during a college class

Born and raised in Lawrence Kan

Gabbert enrolled at the University of

Kansas in 1997 to study computer

engineering He was encouraged to

submit his reacutesumeacute to Pinnacle after

taking a solid state electronics class taught by Chief Technology Officer Dave

research by sharing it with a global

community

Please email us if you are willing

to share your research

CommentsHave a technical question that

needs answering Suggestions

for future issues Let us know

what you want to see in our

newsletter by emailing us at

salespinnacletcomWed love to hear from you

Information2015 Catalog

Product Brochures

Join us on LinkedIn

Request a Manual

Forward this Email

Johnson Despite a class time nap or two his aptitude for the field was

obvious in his grades and test scores and he joined the company while still

an undergraduate in 1999 Although he briefly considered relocating after

earning his bachelorrsquos degree in 2002 he said working at Pinnacle ldquowas a fun

job so I decided to stick with itrdquo

And Gabbert has made the job more fun over the last 16 years helping to

organize intramural sports teams with other Pinnacle employees While

basketball might not have been everyonersquos forte (the team won one game in

three seasons) a Pinnacle kickball team mdash appropriately called the Rats mdash

has now been going three years strong

Back on the job Gabbert has played an integral role in developing many of

Pinnaclersquos turnshykey products including its 8400 series fast scan cyclic

voltammetry and sleep deprivation systems He was also pivotal in launching

Pinnaclersquos optogenetic system which he will showcase and present a poster

on at next monthrsquos APSS SLEEP Meeting 2015 Be sure to say hello if you

plan to attend

Recent PublicationsFor a complete list of publications by Pinnacle customers visit our website at httpwwwpinnacletcompublicationshtml

Biosensor PublicationsLi B amp Freeman RD (2015) Neurometabolic coupling between neural activity glucose and lactate in activated visual

cortex Journal of Neurochemistry 133(5) doi101111jnc13143

Simon DT Larsson KC Nilsson D Burstrom G Galter D Berggren M amp RichtershyDahlfors A (2015) An organic

electronic biomimetic neuron enables autoshyregulated neuromodulation Biosensors and Bioelectronics 71 359shy364

doi101016jbios201504058

Yasuzawa M Toba T Li J Koinkar PM Ueki T amp Fuchiwaki Y (2015) Preparation of microshybiosensor for

continuous glucose monitoring Modern Physics Letter B 29(67) doi101142S0217984915400400

Capillary ElectrophoresisFleck J Marafiga JR Jesse AC Ribeiro LR Rambo LM amp Mello CF (2015) Montelukast potentiates the

anticonvulsant effect of phenobarbital in mice An isobolographic analysis Pharmacological Research 94 24shy41

doi101016jphrs201502001

Nguyen CM Rao S Yang X Dubey S Mays J Cao H amp Chiao JC (2015) SolshyGel deposition of iridium oxide

for biomedical microshydevices Sensors 15 4212shy4228 doi103390s150204212

Seizure PublicationsCitraro R Leo A Marra R De Sarro G amp Russo E (2015) Antiepileptic effects of the selective COXshy2 inhibitor

etoricoxib on the development of spontaneous absence seizures in WAGRij rats Brain Research Bulletin 113 1shy7

doi101016jbrainresbull201502004

Funck VR Ribeiro LR Pereira LM de Oliveira CV Grigoletto J DellashyPace ID Fighera MR Royes LFF

Furian AF Larrick JW amp Oliveira MS (2015) Contrasting effects of Na+ K+shyATPase activation on seizure activity in

acute versus chronic models Neuroscience doi101016jneuroscience201504031

Gonzalez MI Grabenstatter HL CeashyDel Rio CA Del Angel YC Carlsen J Laoprasert RP White AM

Huntsman MM amp BrooksshyKayal A (2015) Seizureshyrelated regulation of GABAshyA in sportaneously epileptic rats

Neurobiology of Disease 77 246=256 doi101016jnbd201503001

Holmes PV Reiss JI Murray PS Dishman RK amp Spradley JM (2015) Chronic exercise dampens hippocampal

glutamate overflow induced by kainic acid in rats Behavioural Brain Research 284 19shy23

doi101016jbbr201502002

Kang SK Markowitz GJ Kim ST Johnston MV amp Kadam SD (2015) Ageshydependent susceptibility to

phenobarbitalshyresistant neonatal seizures Role of chloride coshytransporters Frontiers in Cellular Neuroscience 9(173)

doi103389fncel201500173

Shakarjian MP Ali MS Veliskova J Stanton PK Heck DE amp Velisek L (2015) Combined diazepam and MKshy

801 therapy provides synergistic protection from tetramethylenedisulfotetramineshyinduced tonicshyclonic seizures and lethality

in mice NeuroToxicology 48 100shy108 doi101016jneuro201503007

Silayeva L Deeb TZ Hines RM Kelley MR Munoz MB Lee HHC Brandon NJ Dunlop J Maguire J

Davies PA amp Moss SJ (2015) KCC2 activity is critical in limiting the onset and severity of status epilepticus

Proceedings of the National Academy of Sciences 112 (11) 3523shy3528 doi101073pnas1415126112

SleepWallace A Kim DY Kim KM Chen S Braden B Williams J Jasso K Garcia A Rho JM BimonteshyNelson H

amp Maganti R (2015) Differential effects of duration of sleep fragmentation on spatial learning and synaptic plasticity in

pubertal mice Brain Research doi101016jbrainres201504037

Other PublicationsCho KKA Hoch R Lee AT Patel T Rubenstein JLR amp Sohal VS (2015) Gamma rythyms link prefrontal

interneuron dysfunction with cognitive inflexibility in Dlx56+shy mice Neuron 85(6) 1332shy1343

doi101016jneuron201502019

Nygaard HB Kaufman AC SekineshyKonno T Huh LL Going H Feldman SJ Kostylev MA amp Strittmatter

SM (2015) Brivaracetam but not ethosuximide reverses memory impairments in an Alzheimerrsquos disease mouse model

Alzheimerrsquos Research and Therapy 7(1) 25 doi101186s13195shy015shy0110shy9

Vogt D Cho KKA Lee AT Sohal VS amp Rubenstein JLR (2015) The parvalbuminsomatostatin ratio is

increased in Pten mutant mice and by human Pten ASD alleles Cell Reports doi101016jcelrep201504019

Have you recently published an article that isnt listed Email us and well include your article in our next newsletter

Copyright copy 2015 Pinnacle Technology Inc All rights reserved

Our mailing address isPinnacle Technology Inc2721 Oregon StreetLawrence KS 66046785shy832shy8866

unsubscribe from this list | update subscription preferences