An American HeartAssociation/American Stroke Association Journal

September 2017Volume 48Number 9

IN MEMORIAMFletcher H. McDowell 1923–2017 2335Bruce T. Volpe, MD

EDITORIALSHigh Appraisal of Methodological Quality of Basic Science Articles Published in Stroke 2337Wolf-Rüdiger Schäbitz, MD; Jens Minnerup, MD; Marc Fisher, MD; Jaroslaw Aronowski, MD

Unlocking the Keys to Site Activation and Recruitment Success in a Randomized Controlled Trial

2339

Robert J. Goldberg, PhD; Hoa L. Nguyen, MD, PhD

Towards Improved Translational Stroke Research: Progress and Perspectives of the Recent National Institute of Neurological Disorders and Stroke Consensus Group Meeting

2341

Charlotte Zerna, MD, MSc; Michael D. Hill, MD, MSc; Johannes Boltze, MD, PhD

Hope Dies Last—Evidence Again Fails to Support a Neuroprotectant: Cerebrolysin for Acute Ischemic Stroke

2343

Daniel Bereczki, MD, DSc, FESO

Stroke : Highlights of Selected Articles 2345

ORIGINAL CONTRIBUTIONSClinical SciencesTrajectories in Leisure-Time Physical Activity and Risk of Stroke in Women in the California Teachers Study

2346

Joshua Z. Willey, MD, MS; Jenna Voutsinas, MS; Ayesha Sherzai, MD; Huiyan Ma, MS; Leslie Bernstein, PhD; Mitchell S.V. Elkind, MD, MS; Ying K. Cheung, PhD; Sophia S. Wang, PhD

Incidence of Brain Infarcts, Cognitive Change, and Risk of Dementia in the General Population: The AGES-Reykjavik Study (Age Gene/Environment Susceptibility-Reykjavik Study)

2353

Sigurdur Sigurdsson, MSc; Thor Aspelund, PhD; Olafur Kjartansson, MD; Elias F. Gudmundsson, MSc; Maria K. Jonsdottir, PhD; Gudny Eiriksdottir, MSc; Palmi V. Jonsson, MD, PhD; Mark A. van Buchem, MD, PhD; Vilmundur Gudnason, MD, PhD; Lenore J. Launer, PhD

Dolichoectasia and Small Vessel Disease in Young Patients With Transient Ischemic Attack and Stroke

2361

Vincent Thijs, MD, PhD; Ulrike Grittner, PhD; Franz Fazekas, MD; Dominick J.H. McCabe, MD, PhD; Anne-Katrin Giese, MD; Christof Kessler, MD; Peter Martus, PhD; Bo Norrving, MD; Erich Bernd Ringelstein, MD; Reinhold Schmidt, MD; Christian Tanislav, MD; Jukka Putaala, MD, PhD; Turgut Tatlisumak, MD, PhD; Bettina von Sarnowski, MD; Arndt Rolfs, MD; Christian Enzinger, MD; on behalf of the Stroke in Fabry (SIFAP1) Investigators

Stroke

On the Cover: The image is taken from an article in this issue, “Fletcher H. McDowell 1923–2017” by Volpe (Stroke. 2017; 48:2335–2336. doi: 10.1161/STROKEAHA.117.018798).

CME

OPEN ACCESS

DATA SUPPLEMENT

by guest on May 21, 2018

http://stroke.ahajournals.org/D

ownloaded from

CME

OPEN ACCESS

DATA SUPPLEMENT

Type 2 Diabetes Mellitus and Impaired Renal Function Are Associated With Brain Alterations and Poststroke Cognitive Decline

2368

Einor Ben Assayag, PhD; Roy Eldor, MD, PhD; Amos D. Korczyn, MD, MSc; Efrat Kliper, PhD; Shani Shenhar-Tsarfaty, PhD; Oren Tene, MD; Jeremy Molad, MD; Itzhak Shapira, MD; Shlomo Berliner, MD, PhD; Viki Volfson, MSc; Ludmila Shopin, MD; Yehuda Strauss, MD; Hen Hallevi, MD; Natan M. Bornstein, MD; Eitan Auriel, MD, MSc

Focal Cerebral Arteriopathy: Do Steroids Improve Outcome? 2375Maja Steinlin, MD; Sandra Bigi, MD, MSc; Belinda Stojanovski, BS; Jay Gajera, MD; Maria Regényi, MD; Marwan El-Koussy, MD; Mark T. Mackay, MBBS, PhD; on behalf of the Swiss NeuroPediatric Stroke Registry

Readmission After Aneurysmal Subarachnoid Hemorrhage: A Nationwide Readmission Database Analysis

2383

Hormuzdiyar H. Dasenbrock, MD, MPH; Frederico Angriman, MD; Timothy R. Smith, MD, PhD, MPH; William B. Gormley, MD, MPH, MBA; Kai U. Frerichs, MD; M. Ali Aziz-Sultan, MD; Rose Du, MD, PhD

MicroRNA Changes in Cerebrospinal Fluid After Subarachnoid Hemorrhage 2391Søren Bache, MD; Rune Rasmussen, MD, PhD; Maria Rossing, MD, PhD; Finn Pedersen Laigaard, MD; Finn Cilius Nielsen, MD, PhD, DMSci; Kirsten Møller, MD, PhD, DMSci

Risk Factors of Sudden Death From Subarachnoid Hemorrhage 2399Joni Valdemar Lindbohm, MD; Jaakko Kaprio, MD, PhD; Pekka Jousilahti, MD, PhD; Veikko Salomaa, MD, PhD; Miikka Korja MD, PhD

Vascular Risk Factor Profiles Differ Between Magnetic Resonance Imaging-Defined Subtypes of Younger-Onset Lacunar Stroke

2405

Loes C.A. Rutten-Jacobs, PhD; Hugh S. Markus, DM; on behalf of the UK Young Lacunar Stroke DNA Study

Permeability Surface of Deep Middle Cerebral Artery Territory on Computed Tomographic Perfusion Predicts Hemorrhagic Transformation After Stroke

2412

Qiao Li, MD; Xinyi Gao, MSc; Zhenwei Yao, MD, PhD; Xiaoyuan Feng, MD, PhD; Huijin He, MD, PhD; Jing Xue, MD, PhD; Peiyi Gao, MD, PhD; Lumeng Yang, MD; Xin Cheng, MD, PhD; Weijian Chen, MD; Yunjun Yang, MD, PhD

Blood Biomarkers for the Early Diagnosis of Stroke: The Stroke-Chip Study 2419Alejandro Bustamante, MD, PhD; Elena López-Cancio, MD, PhD; Sara Pich, PhD; Anna Penalba, BsC; Dolors Giralt, MsC; Teresa García-Berrocoso, PhD; Carles Ferrer-Costa, PhD; Teresa Gasull, PhD; María Hernández-Pérez, MD, PhD; Mónica Millan, MD, PhD; Marta Rubiera, MD, PhD; Pedro Cardona, MD, PhD; Luis Cano, MD; Helena Quesada, MD; Mikel Terceño, MD; Yolanda Silva, MD, PhD; Mar Castellanos, MD, PhD; Moisés Garces, MD; Silvia Reverté, PhD; Xavier Ustrell, MD; Rafael Marés, MD, PhD; Joan Josep Baiges, MD, PhD; Joaquín Serena, MD, PhD, Francisco Rubio, MD, PhD; Eduardo Salas, MD, PhD, Antoni Dávalos, MD, PhD; Joan Montaner, MD, PhD

Association of Computed Tomography Ischemic Lesion Location With Functional Outcome in Acute Large Vessel Occlusion Ischemic Stroke

2426

Marielle Ernst, MD; Anna M.M. Boers; Annette Aigner; Olvert A. Berkhemer, MD; Albert J. Yoo, MD, PhD; Yvo B. Roos, MD, PhD; Diederik W.J. Dippel, MD, PhD; Aad van der Lugt, MD, PhD; Robert J. van Oostenbrugge, MD, PhD; Wim H. van Zwam, MD, PhD; Jens Fiehler, MD; Henk A. Marquering, PhD; Charles B.L.M. Majoie, MD, PhD; on behalf of the MR CLEAN Trial Investigators (www.mrclean-trial.org)

Detection of Left Ventricular Thrombus by Cardiac Magnetic Resonance in Embolic Stroke of Undetermined Source

2434

Junji Takasugi, MD; Hiroshi Yamagami, MD; Teruo Noguchi, MD; Yoshiaki Morita, MD; Tomotaka Tanaka, MD; Yoshinori Okuno, MD; Satoshi Yasuda, MD; Kazunori Toyoda, MD; Yasufumi Gon, MD; Kenichi Todo, MD; Manabu Sakaguchi, MD; Kazuyuki Nagatsuka, MD

Long-Delay Arterial Spin Labeling Provides More Accurate Cerebral Blood Flow Measurements in Moyamoya Patients: A Simultaneous Positron Emission Tomography/MRI Study

2441

Audrey P. Fan, PhD; Jia Guo, PhD; Mohammad M. Khalighi, PhD; Praveen K. Gulaka, PhD; Bin Shen, PhD; Jun Hyung Park, PhD; Harsh Gandhi, MS; Dawn Holley, BS, CNMT; Omar Rutledge, MS; Prachi Singh, PhD; Tom Haywood, PhD; Gary K. Steinberg, MD, PhD; Frederick T. Chin, PhD; Greg Zaharchuk, MD, PhD

by guest on May 21, 2018

http://stroke.ahajournals.org/D

ownloaded from

CME

OPEN ACCESS

DATA SUPPLEMENT

Mechanical Thrombectomy Outcomes With and Without Intravenous Thrombolysis in Stroke Patients: A Meta-Analysis

2450

Eva A. Mistry, MD; Akshitkumar M. Mistry, MD; Mohammad Obadah Nakawah, MD; Rohan V. Chitale, MD; Robert F. James, MD; John J. Volpi, MD; Matthew R. Fusco, MD

Emergency Coagulation Assessment During Treatment With Direct Oral Anticoagulants: Limitations and Solutions

2457

Matthias Ebner, MD; Ingvild Birschmann, MD, PhD; Andreas Peter, MD; Florian Härtig, MD; Charlotte Spencer; Joachim Kuhn, PhD; Gunnar Blumenstock, MPH; Christine S. Zuern, MD; Ulf Ziemann, MD; Sven Poli, MD

Predictors for Cerebral Edema in Acute Ischemic Stroke Treated With Intravenous Thrombolysis

2464

Magnus Thorén, MD; Elsa Azevedo, MD, PhD; Jesse Dawson, MD, Jose A. Egido, MD, MPhil; Anne Falcou, MD, PhD, MSc; Gary A. Ford, MD; Staffan Holmin, MD, PhD; Robert Mikulik, MD, PhD; Jyrki Ollikainen, MD, Nils Wahlgren, MD, PhD; Niaz Ahmed, MD, PhD

Warfarin Use in Patients With Atrial Fibrillation Undergoing Hemodialysis: A Nationwide Population-Based Study

2472

Chang-Yun Yoon, MD; Juhwan Noh, MD; Jong Hyun Jhee, MD; Tae Ik Chang, MD, PhD; Ea Wha Kang, MD, PhD; Youn Kyung Kee, MD; Hyoungnae Kim, MD; Seohyun Park, MD; Hae-Ryong Yun, MD; Su-Young Jung, MD; Hyung Jung Oh, MD, PhD; Jung Tak Park, MD, PhD; Seung Hyeok Han, MD, PhD; Shin-Wook Kang, MD, PhD; Changsoo Kim, MD, PhD; Tae-Hyun Yoo, MD, PhD

Ticagrelor Versus Aspirin in Acute Embolic Stroke of Undetermined Source 2480Pierre Amarenco, MD; Gregory W. Albers, MD; Hans Denison, MD, PhD; J. Donald Easton, MD; Scott R. Evans, PhD; Peter Held, MD, PhD; Michael D. Hill, MD; Jenny Jonasson, PhD; Scott E. Kasner, MD; Per Ladenvall, MD, PhD; Kazuo Minematsu, MD, PhD; Carlos A. Molina, MD; Yongjun Wang, MD; K.S. Lawrence Wong, MD; S. Claiborne Johnston, MD; PhD; on behalf of the SOCRATES Steering Committee and Investigators

Rethinking Thrombolysis in Cerebral Infarction 2b: Which Thrombolysis in Cerebral Infarction Scales Best Define Near Complete Recanalization in the Modern Thrombectomy Era?

2488

Eric L. Tung, BSc; Ryan A. McTaggart, MD; Grayson L. Baird, PhD; Shadi Yaghi, MD; Morgan Hemendinger, BA; Eleanor L. Dibiasio, BA, MPh; Douglas T. Hidlay, MD; Glenn A. Tung, MD; Mahesh V. Jayaraman, MD

Real-World Setting Comparison of Nonvitamin-K Antagonist Oral Anticoagulants Versus Vitamin-K Antagonists for Stroke Prevention in Atrial Fibrillation: A Systematic Review and Meta-Analysis

2494

George Ntaios, MD; Vasileios Papavasileiou, MD; Konstantinos Makaritsis, MD; Konstantinos Vemmos, MD; Patrik Michel, MD; Gregory Y.H. Lip, MD

Community-Based Intervention to Improve Cardiometabolic Targets in Patients With Stroke: A Randomized Controlled Trial

2504

Muideen T. Olaiya, PhD; Dominique A. Cadilhac, PhD; Joosup Kim, PhD; Mark R. Nelson, PhD; Velandai K. Srikanth, PhD; Richard P. Gerraty, MD; Christopher F. Bladin, PhD; Sharyn M. Fitzgerald, PhD; Thanh Phan, PhD; Judith Frayne, MBBS; Amanda G. Thrift, PhD

Factors Associated With Time to Site Activation, Randomization, and Enrollment Performance in a Stroke Prevention Trial

2511

Bart M. Demaerschalk, MD; Robert D. Brown, Jr, MD; Gary S. Roubin, MD; Virginia J. Howard, PhD; Eldina Cesko, BS; Kevin M. Barrett, MD; Mary E. Longbottom, BA, CCRP; Jenifer H. Voeks, PhD; Seemant Chaturvedi, MD; Thomas G. Brott, MD; Brajesh K. Lal, MD; James F. Meschia, MD; George Howard, DrPH; for the CREST-2 Investigators

Systematic Review of the Cost and Cost-Effectiveness of Rapid Endovascular Therapy for Acute Ischemic Stroke

2519

Laura K. Sevick, BSc; Sarah Ghali; Michael D. Hill, MD; Vishva Danthurebandara, PhD; Diane L. Lorenzetti, PhD; Tom Noseworthy, MD; Eldon Spackman, PhD; Fiona Clement, PhD

Impact of Stroke Center Certification on Mortality After Ischemic Stroke: The Medicare Cohort From 2009 to 2013

2527

Shumei Man, MD, PhD; Jesse D. Schold, PhD; Ken Uchino, MD

by guest on May 21, 2018

http://stroke.ahajournals.org/D

ownloaded from

CME

OPEN ACCESS

DATA SUPPLEMENT

Palliative Care for Hospitalized Patients With Stroke: Results From the 2010 to 2012 National Inpatient Sample

2534

Tarvinder Singh, MD; Steven R. Peters, MD; David L. Tirschwell, MD; Claire J. Creutzfeldt, MD

Basic SciencesCircular RNA Expression Profiles Alter Significantly in Mouse Brain After Transient Focal Ischemia

2541

Suresh L. Mehta, PhD; Gopal Pandi, PhD; Raghu Vemuganti, PhD

Genetic Inhibition of Receptor Interacting Protein Kinase-1 Reduces Cell Death and Improves Functional Outcome After Intracerebral Hemorrhage in Mice

2549

Sevda Lule, PhD; Limin Wu, MD, PhD; Lauren M. McAllister, MA; William J. Edmiston III, BS; Joon Yong Chung, BS; Emily Levy; Yi Zheng, PhD; Peter J. Gough, PhD; John Bertin, PhD; Alexei Degterev, PhD; Eng H. Lo, PhD; Michael J. Whalen, MD

Brain Transforming Growth Factor-β Resists Hypertension Via Regulating Microglial Activation

2557

You Li, BS; Xiao Z. Shen, MD; Liang Li, MS; Tuantuan V. Zhao, MS; Kenneth E. Bernstein, MD; Alan K. Johnson, PhD; Patrick Lyden, MD; Jianmin Fang, PhD; Peng Shi, PhD

Carbon Monoxide Preserves Circadian Rhythm to Reduce the Severity of Subarachnoid Hemorrhage in Mice

2565

Nils Schallner, MD; Judith-Lisa Lieberum; David Gallo, BS; Robert H. LeBlanc III, MS; Patrick M. Fuller, PhD; Khalid A. Hanafy, MD, PhD; Leo E. Otterbein, PhD

Vascular Tissue-Type Plasminogen Activator Promotes Intracranial Aneurysm Formation 2574Paul-Emile Labeyrie, MD, MSc; Romain Goulay, PhD; Sara Martinez de Lizarrondo, PhD; Marie Hébert, PhD; Maxime Gauberti, PhD; Eric Maubert, PhD; Barbara Delaunay, MSc; Benjamin Gory, MD, PhD; Francesco Signorelli, MD, MSc; Francis Turjman, MD, PhD; Emmanuel Touzé, MD, PhD; Patrick Courthéoux, MD; Denis Vivien, PhD; Cyrille Orset, PhD

BRIEF REPORTSEarly Dysphagia Screening by Trained Nurses Reduces Pneumonia Rate in Stroke Patients: A Clinical Intervention Study

2583

Christoph Palli, MScN; Simon Fandler, MD; Kathrin Doppelhofer; Kurt Niederkorn, MD; Christian Enzinger, MD; Christian Vetta, MD; Esther Trampusch; Reinhold Schmidt, MD; Franz Fazekas, MD; Thomas Gattringer, MD, PhD

Plasma Glial Fibrillary Acidic Protein in the Differential Diagnosis of Intracerebral Hemorrhage

2586

Aristeidis H. Katsanos, MD; Konstantinos Makris, PhD; Dimitra Stefani, MD; Katerina Koniari, MD; Eleni Gialouri, MD; Moses Lelekis, MD; Maria Chondrogianni, MD; Christina Zompola, MD; Efthymios Dardiotis, MD; Ioannis Rizos, MD; John Parissis, MD; Eleni Boutati, MD; Konstantinos Voumvourakis, MD; Georgios Tsivgoulis, MD

Neutrophil–Lymphocyte Ratio and Perihematomal Edema Growth in Intracerebral Hemorrhage

2589

Aaron M. Gusdon, MD; Gino Gialdini, MD; Gbambele Kone, BS; Hediyeh Baradaran, MD; Alexander E. Merkler, MD; Halinder S. Mangat, MD; Babak B. Navi, MD, MS; Costantino Iadecola, MD; Ajay Gupta, MD; Hooman Kamel, MD; Santosh B. Murthy, MD, MPH

Prediction of Clinical Outcome After Acute Ischemic Stroke: The Value of Repeated Noncontrast Computed Tomography, Computed Tomographic Angiography, and Computed Tomographic Perfusion

2593

Jan W. Dankbaar, MD; Alexander D. Horsch, MD; Andor F. van den Hoven, MD; L. Jaap Kappelle, MD; Irene C. van der Schaaf, MD; Tom van Seeters, MD; Birgitta K. Velthuis, MD; on behalf of the DUST Investigators

Early Imaging Prediction of Malignant Cerebellar Edema Development in Acute Ischemic Stroke

2597

Matthias P. Fabritius, MD; Kolja M. Thierfelder, MD, MSc; Felix G. Meinel, MD; Ahmed E. Othman, MD; Franziska Dorn, MD; Bastian O. Sabel, MD; Pierre Scheffler, MD; Birgit Ertl-Wagner, MD, MHBA; Wieland H. Sommer, MD, MPH; Wolfgang G. Kunz, MD

by guest on May 21, 2018

http://stroke.ahajournals.org/D

ownloaded from

CME

OPEN ACCESS

DATA SUPPLEMENT

Detecting Intracranial Vessel Wall Lesions With 7T-Magnetic Resonance Imaging: Patients With Posterior Circulation Ischemia Versus Healthy Controls

2601

Anita A. Harteveld, PhD; Anja G. van der Kolk, MD, PhD; H. Bart van der Worp, MD, PhD; Nikki Dieleman, PhD; Jaco J.M. Zwanenburg, PhD; Peter R. Luijten, PhD; Jeroen Hendrikse, MD, PhD

Influence of Renal Impairment on Outcome for Thrombolysis-Treated Acute Ischemic Stroke: ENCHANTED (Enhanced Control of Hypertension and Thrombolysis Stroke Study) Post Hoc Analysis

2605

Susan J. Carr, MD; Xia Wang, PhD; Veronica V. Olavarria, MD; Pablo M. Lavados, MD; Jorge A. Rodriguez, MD; Jong S. Kim, MD, PhD; Tsong-Hai Lee, MD, PhD; Richard I. Lindley, MD; Octavio M. Pontes-Neto, DM, PhD; Stefano Ricci, MD; Shoichiro Sato, MD, PhD; Vijay K. Sharma, MD; Mark Woodward, PhD; John Chalmers, MD, PhD; Craig S. Anderson, MD, PhD; Thompson G. Robinson, MD; on behalf of the ENCHANTED Investigators

Antiplatelet Regimen for Patients With Breakthrough Strokes While on Aspirin: A Systematic Review and Meta-Analysis

2610

Meng Lee, MD; Jeffrey L. Saver, MD; Keun-Sik Hong, MD, PhD; Neal M. Rao, MD; Yi-Ling Wu, MS; Bruce Ovbiagele, MD

Consumer-Based Physical Activity Monitor as a Practical Way to Measure Walking Intensity During Inpatient Stroke Rehabilitation

2614

Tara D. Klassen, MSc; Jennifer A. Semrau, PhD; Sean P. Dukelow, MD; Mark T. Bayley, MD; Michael D. Hill, MD; Janice J. Eng, PhD

Benchmarking Telestroke Proficiency: Page-to-Needle Time Among Neurovascular Fellows and Attendings

2618

Amanda L. Jagolino-Cole, MD; Shima Bozorgui, MD, MPH; Christy M. Ankrom, BS; Arvind B. Bambhroliya, MD, MPH; Tiffany D. Cossey, MD; Alyssa D. Trevino, BA; Sean I. Savitz, MD; Tzu-Ching Wu, MD; Farhaan S. Vahidy, MD, PhD

COMMENTS AND OPINIONSFast Versus Slow Progressors of Infarct Growth in Large Vessel Occlusion Stroke: Clinical and Research Implications

2621

Marcelo Rocha, MD, PhD; Tudor G. Jovin, MD

SPECIAL REPORTSWilliam M. Feinberg Award for Excellence in Clinical Stroke: Big Pictures and Small Vessels 2628Steven M. Greenberg, MD, PhD

Translational Stroke Research: Vision and Opportunities 2632Francesca Bosetti, PharmD, PhD; James I. Koenig, PhD; Cenk Ayata, MD; Stephen A. Back, MD, PhD; Kyra Becker; MD; Joseph P. Broderick, MD; S. Thomas Carmichael, MD, PhD; Sunghee Cho, PhD; Marilyn J. Cipolla, PhD; Dale Corbett, PhD; Roderick A. Corriveau, PhD; Steven C. Cramer, MD; Adam R. Ferguson, PhD; Seth P. Finklestein, MD; Byron D. Ford, PhD; Karen L. Furie, MD; Thomas M. Hemmen, MD, PhD; Costantino Iadecola, MD; Lyn B. Jakeman, PhD; Scott Janis, PhD; Edward C. Jauch, MD; Karen C. Johnston, MD; Patrick M. Kochanek, MD; Harold Kohn, PhD; Eng H. Lo, PhD; Patrick D. Lyden, MD; Carina Mallard, PhD; Louise D. McCullough, MD, PhD; Linda M. McGavern, PhD; James F. Meschia, MD; Claudia S. Moy, PhD; Miguel A. Perez-Pinzon, PhD; Ipolia Ramadan, PhD; Sean I. Savitz, MD; Lee H. Schwamm, MD; Gary K. Steinberg, MD, PhD; Mary P. Stenzel-Poore, PhD; Michael Tymianski, MD, PhD; Steven Warach, MD, PhD; Lawrence R. Wechsler, MD; John H. Zhang, MD, PhD; Walter Koroshetz, MD

TOPICAL REVIEWUse and Timing of Tracheostomy After Severe Stroke 2638Julian Bösel, MD

CONTROVERSIES IN STROKEProthrombin Complex Concentrates Use in Intracerebral Hemorrhage 2644Sven Poli, MD; Florian Härtig, MD; Magdy H. Selim, MD, PhD; Carlos A. Molina, MD, PhD; Dar Dowlatshahi, MD

by guest on May 21, 2018

http://stroke.ahajournals.org/D

ownloaded from

CME

OPEN ACCESS

DATA SUPPLEMENT

STROKE LITERATURE SYNOPSES: CLINICAL SCIENCE

Terence J. Quinn, MD e243

COCHRANE CORNERCerebrolysin for Acute Ischemic Stroke e245Liliya Eugenevna Ziganshina, MD, PhD, DSci; Tatyana Abakumova, MD, PhD; Ludivine Vernay, ME

Antithrombotic Treatment After Stroke Because Of Intracerebral Hemorrhage e247Luke A. Perry, BSc; Eivind Berge, PhD; Joshua Bowditch, BSc(Hons); Elisabeth Forfang, MD; Ole Morten Rønning, PhD; Graeme J. Hankey, MD; Elmer Villanueva, MD; Rustam Al-Shahi Salman, PhD

INTERSECTIdentifying the Right Mentor e248Luciana Catanese, MD; Ashkan Shoamanesh, MD

ORGANIZATIONAL UPDATESOrganizational Update: Asia Pacific Stroke Organization e252Narayanaswamy Venketasubramanian, MBBS, MMed, FRCP(Edin); Craig Anderson, MD, PhD; Manmohan Mehndiratta, MD, FRCP; Ruey-Tay Lin, MD; Kay-Sin Tan, MBBS, FRCP; Chen-Ya Huang, MMed, FRACP, FHKCP

LETTERS TO THE EDITORLetter by Tampaki et al Regarding Article, “Empagliflozin and Cerebrovascular Events in Patients With Type 2 Diabetes Mellitus at High Cardiovascular Risk”

e255

Ekaterini Christina Tampaki, MD, PhD, Dipl Pharm; Athanasios Tampakis, MD; Lorenz Gürke, MD, Prof Dr med

Response by Zinman et al to Letter Regarding Article, “Empagliflozin and Cerebrovascular Events in Patients With Type 2 Diabetes Mellitus at High Cardiovascular Risk”

e256

Bernard Zinman, MD; Silvio E. Inzucchi, MD; Hans Christoph Diener, MD

Letter by Shah Regarding Article, “Randomized, Multicenter Trial of ARTSS-2 (Argatroban With Recombinant Tissue Plasminogen Activator for Acute Stroke)”

e258

Nirav H. Shah, MD

Response by Barreto and Grotta to Letter Regarding Article, “Randomized, Multicenter Trial of ARTSS-2 (Argatroban With Recombinant Tissue Plasminogen Activator for Acute Stroke)”

e259

Andrew D. Barreto, MD, MS; James C. Grotta, MD

Letter by Liberman et al Regarding Article, “Psychiatric Hospitalization Increases Short-Term Risk of Stroke”

e260

Ava L. Liberman, MD; Shyam Prabhakaran, MD, MS; David E. Newman-Toker, MD, PhD

Response by Zuflacht et al to Letter Regarding Article, “Psychiatric Hospitalization Increases Short-Term Risk of Stroke”

e261

Jonah P. Zuflacht, MD; Mitchell S.V. Elkind, MD, MS, MPhil; Joshua Z. Willey, MD, MS

Letter by O’Sullivan Regarding Article, “Neurons Over Nephrons: Systematic Review and Meta-Analysis of Contrast-Induced Nephropathy in Patients With Acute Stroke”

e262

Eoin D O’Sullivan MB, BCh, BAO

Response by Brinjikji et al to Letter Regarding Article, “Neurons Over Nephrons: Systematic Review and Meta-Analysis of Contrast-Induced Nephropathy in Patients With Acute Stroke”

e263

Waleed Brinjikji, MD; David F. Kallmes, MD; Alejandro A. Rabinstein, MD

by guest on May 21, 2018

http://stroke.ahajournals.org/D

ownloaded from

CME

OPEN ACCESS

DATA SUPPLEMENT

Letter by Tang et al Regarding Article, “General Anesthesia Versus Conscious Sedation for Endovascular Treatment of Acute Ischemic Stroke: The Anstroke Trial (Anesthesia During Stroke)”

e264

Rongrui Tang, MD; Yu Zhang, MD; Rubing Yan, MD

Response by Löwhagen Hendén and Rentzos to Letter Regarding Article, “General Anesthesia Versus Conscious Sedation for Endovascular Treatment of Acute Ischemic Stroke: The Anstroke Trial (Anesthesia During Stroke)”

e265

Pia Löwhagen Hendén, MD, PhD; Alexandros Rentzos, MD

Letter by Barco et al Regarding Article, “Restarting Anticoagulant Therapy After Intracranial Hemorrhage: A Systematic Review and Meta-Analysis”

e266

Stefano Barco, MD, PhD; Frederikus A. Klok, MD, PhD; Francesco Dentali, MD

Response by Murthy et al to Letter Regarding Article, “Restarting Anticoagulant Therapy After Intracranial Hemorrhage: A Systematic Review and Meta-Analysis”

e267

Santosh B. Murthy, MD, MPH; Ajay Gupta, MD; Hooman Kamel, MD

Letter by Fenton and Bellman Regarding Article, “Sugar- and Artificially Sweetened Beverages and the Risks of Incident Stroke and Dementia: A Prospective Cohort Study”

e268

Tanis Fenton, PhD, RD; Jane Bellman, MEd, RD

Response by Pase et al to Letter Regarding Article, “Sweetened Beverages and the Risks of Incident Stroke and Dementia”

e269

Matthew P. Pase, PhD; Jayandra J. Himali, PhD; Sudha Seshadri, MD; Paul F. Jacques, DSc

CORRECTIONSCorrection to: Effect of Long-Term Vascular Care on Progression of Cerebrovascular Lesions: Magnetic Resonance Imaging Substudy of the PreDIVA Trial (Prevention of Dementia by Intensive Vascular Care)

e270

Correction to: Lifestyle Interventions to Prevent Cardiovascular Events After Stroke and Transient Ischemic Attack: Systematic Review and Meta-Analysis

e271

Correction to: Long-Term Improvements After Multimodal Rehabilitation in Late Phase After Stroke: A Randomized Controlled Trial

e272

Correction to: Role of Periostin in Early Brain Injury After Subarachnoid Hemorrhage in Mice e273

Correction to: Optimal Timing of Diffusion-Weighted Imaging to Avoid False-Negative Findings in Patients With Transient Ischemic Attack

e274

STROKE (ISSN 0039-2499) is published monthly by Wolters Kluwer Health, Inc., at 14700 Citicorp Drive, Bldg 3, Hagerstown, MD 21742. Business offices are located at Two Commerce Square, 2001 Market Street, Philadelphia, PA 19103. Production offices are located at 351 West Camden Street, Baltimore, MD 21201-2436. Individuals may subscribe for their personal use at the following rates for print subscriptions: $225 for AHA/ASA Domestic and International Members (excluding General Membership level), or $582 for domestic non-members and $721 for international non-members. AHA membership information can be found online at professional.heart.org. Periodicals postage paid at Hagerstown, MD, and additional mailing offices. POSTMASTER: Send address changes to STROKE, American Heart Association, Wolters Kluwer Health, Inc., PO Box 1610, Hagerstown, MD 21740.

by guest on May 21, 2018

http://stroke.ahajournals.org/D

ownloaded from

48 (9)

Print ISSN: 0039-2499. Online ISSN: 1524-4628 Copyright © 2017 American Heart Association, Inc. All rights reserved.

is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231Stroke 2017;48:e274-2646Stroke. 

http://stroke.ahajournals.org/content/48/9World Wide Web at:

The online version of this article, along with updated information and services, is located on the

  http://stroke.ahajournals.org//subscriptions/

is online at: Stroke Information about subscribing to Subscriptions: 

http://www.lww.com/reprints Information about reprints can be found online at: Reprints:

  document. Permissions and Rights Question and Answer process is available in the

Request Permissions in the middle column of the Web page under Services. Further information about thisOnce the online version of the published article for which permission is being requested is located, click

can be obtained via RightsLink, a service of the Copyright Clearance Center, not the Editorial Office.Strokein Requests for permissions to reproduce figures, tables, or portions of articles originally publishedPermissions:

by guest on May 21, 2018

http://stroke.ahajournals.org/D

ownloaded from