IMPORTANTNOTICE

• AllDEMYSTIFYINGMEDICINESESSIONSCANBEVIEWEDLIVEFROMANYWHEREONEARTHAT….VIDEOCAST.NIH.GOV

• 1-2WKSLATER,ALLSESSIONSAREONU-TUBEAVAILABLEWORLDWIDE

INFLAMMATION

Latin:inflammatio:“tosetonfire”

1st CphysicianCelsus:Calor/HEATRubor/REDNESSSTumor/SWELLING

Dolor/PAIN…resultinginLOSSOFFUNCTION

21st Century• Roleofinflammationinotherdiseaseprocesses:• Cardiovasculardiseases(CAD,etc)(Jan24)• Allergies(Jan31)• Immunosuppressivediseases(HIV,etc)(Feb28)• Cancer(Feb21)• Fibrosis(March21)• Autoimmunediseases(RA,etc)• Neurodegenerativediseases(Alzheimer,etc)(April11)• Obesity• WHAT’SNEXT???

Glyco-mics

• TheGenomedidnotanswereverything!• Epigenetics….posttranslationalmodificationsgreatlyexpandscopeoffunction

Glycoproteinandglycolipidbiologyarecriticalindiversefunctions,regulationanddisease….bothinheritableandacquired.

20th CIMMUNITY

• ElieMetchnikoff….discoversInnateImmuneSystemfromstudiesof“splinterinastarfish”1882(VikhanskiL:“Immunity” HowMetchnikoffchangedthecourseofmodernmedicine2016ChicagoReviewPress)

• AdaptiveImmuneSystem...20thCexplosion...discoveryofantigen-mediatedcellresponse,TandBcells,etc....